Reviewer's report
Title:The overexpression of Sterol Carrier Protein 2 gene in patients of
hereditary cholesterol gallstones
Version: 6Date:5 October 2010
Reviewer: Ahmet Tekin
Reviewer's report:
The Authors investigated the expression level of liver SCP2 gene in hereditary
and non-hereditary cholesterol gallstone patients and non-cholesterol gallstone
patients and they found that Cholesterol Saturation Index (CSI) significant
differences in between cholesterol gallstone patients and non-cholesterol
gallstone patients, but there was no significant difference in CSI between
hereditary and non-hereditary cholesterol gallstone patients. The topic of the
manuscript is good. The study structured quite well. But there are too many
majors and minors grammatical errors. I edited the text and recommended some
sentences. The text should be re-written upon my recommendation. There are
also some errors in the references.
These group has similar study in 2005 (Cui NQ, Zhang SK, Cui YF
etal:Overexpression of sterol carrier protein-2 mRNA in patients with
cholesterolgallstone. Hepatobiliary Pancreat Dis Int 2005,4:117-20). The Authors
should discuss the differences between the former and the current study in the
discussion section. What is the new in the current study?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:The overexpression of Sterol Carrier Protein 2 gene in patients of
hereditary cholesterol gallstones
Version: 6Date:5 October 2010
Reviewer: Ahmet Tekin
Reviewer's report:
The Authors investigated the expression level of liver SCP2 gene in hereditary
and non-hereditary cholesterol gallstone patients and non-cholesterol gallstone
patients and they found that Cholesterol Saturation Index (CSI) significant
differences in between cholesterol gallstone patients and non-cholesterol
gallstone patients, but there was no significant difference in CSI between
hereditary and non-hereditary cholesterol gallstone patients. The topic of the
manuscript is good. The study structured quite well. But there are too many
majors and minors grammatical errors. I edited the text and recommended some
sentences. The text should be re-written upon my recommendation. There are
also some errors in the references.
These group has similar study in 2005 (Cui NQ, Zhang SK, Cui YF
etal:Overexpression of sterol carrier protein-2 mRNA in patients with
cholesterolgallstone. Hepatobiliary Pancreat Dis Int 2005,4:117-20). The Authors
should discuss the differences between the former and the current study in the
discussion section. What is the new in the current study?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:The overexpression of Sterol Carrier Protein 2 gene in patients of
hereditary cholesterol gallstones
Version: 6Date:5 October 2010
Reviewer: Ahmet Tekin
Reviewer's report:
The Authors investigated the expression level of liver SCP2 gene in hereditary
and non-hereditary cholesterol gallstone patients and non-cholesterol gallstone
patients and they found that Cholesterol Saturation Index (CSI) significant
differences in between cholesterol gallstone patients and non-cholesterol
gallstone patients, but there was no significant difference in CSI between
hereditary and non-hereditary cholesterol gallstone patients. The topic of the
manuscript is good. The study structured quite well. But there are too many
majors and minors grammatical errors. I edited the text and recommended some
sentences. The text should be re-written upon my recommendation. There are
also some errors in the references.
These group has similar study in 2005 (Cui NQ, Zhang SK, Cui YF
etal:Overexpression of sterol carrier protein-2 mRNA in patients with
cholesterolgallstone. Hepatobiliary Pancreat Dis Int 2005,4:117-20). The Authors
should discuss the differences between the former and the current study in the
discussion section. What is the new in the current study?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant