Reviewer’s report
Title:  Evaluation  of  ultrasound-guided  Freka-Trelumina  enteral  nutrition  tube  placement  in  the
treatment of acute pancreatitis
Version: 0 Date: 22 Aug 2019
Reviewer: Zhihui Tong
Reviewer's report:
This is a good organized and well performed study reporting the placement of ultrasound-guided Freka-
Trelumina enteral nutrition tube, which was proven to be safe and convenient. We have noticed that the
author  has  added  another  group  of  patients  which  were  managed  with  endoscope-guided  tube
placement.
We found that the success rate of tube placement, the incidence of the adverse events as well as
associated complications between two groups were similar. The findings were encouraging.
Advises:
We advise the authors to use tables to record and display the baseline data, procedure associated
indicators as well as complications of the two groups. The statistical comparison between the two
groups is needed. 
We advise an English native-speaker to help polish your language.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
Reviewer’s report
Title:  Evaluation  of  ultrasound-guided  Freka-Trelumina  enteral  nutrition  tube  placement  in  the
treatment of acute pancreatitis
Version: 0 Date: 22 Aug 2019
Reviewer: Zhihui Tong
Reviewer's report:
This is a good organized and well performed study reporting the placement of ultrasound-guided Freka-
Trelumina enteral nutrition tube, which was proven to be safe and convenient. We have noticed that the
author  has  added  another  group  of  patients  which  were  managed  with  endoscope-guided  tube
placement.
We found that the success rate of tube placement, the incidence of the adverse events as well as
associated complications between two groups were similar. The findings were encouraging.
Advises:
We advise the authors to use tables to record and display the baseline data, procedure associated
indicators as well as complications of the two groups. The statistical comparison between the two
groups is needed. 
We advise an English native-speaker to help polish your language.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’s report
Title:  Evaluation  of  ultrasound-guided  Freka-Trelumina  enteral  nutrition  tube  placement  in  the
treatment of acute pancreatitis
Version: 0 Date: 22 Aug 2019
Reviewer: Zhihui Tong
Reviewer's report:
This is a good organized and well performed study reporting the placement of ultrasound-guided Freka-
Trelumina enteral nutrition tube, which was proven to be safe and convenient. We have noticed that the
author  has  added  another  group  of  patients  which  were  managed  with  endoscope-guided  tube
placement.
We found that the success rate of tube placement, the incidence of the adverse events as well as
associated complications between two groups were similar. The findings were encouraging.
Advises:
We advise the authors to use tables to record and display the baseline data, procedure associated
indicators as well as complications of the two groups. The statistical comparison between the two
groups is needed. 
We advise an English native-speaker to help polish your language.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
assistant