Title: Conditional survival and the prognostic value of serum carcinoembryonic antigen level
in oldest old with colorectal cancer
Version: 2 Date: 03 Apr 2023
Reviewer:  Rongbo Wen
Reviewer's report:
This manuscript used the SEER database to evaluate the conditional survival for the oldest-old
patients and the serum CEA level was a useful indication for the prediction of survival. The
study was well-organized and had clinical guidance for the management for the oldest-old CRC
patients. Here were the advices for this manuscript.
1. The language should be improve by the native English speakers for there were many grammar
mistakes.
2. The authors used the SEER database which was a American database, what were the results of
the conditional survival in the authors’ center? Could the authors provide the external validation
by using other data?
3. The author found that C-stage combining TNM stage was meaningful, but what about the
prediction accuracy for the other patients? If the C-stage was also meaningful in all patients, the
clinical meaning of C-stage in oldest-old patients would be doubted.
Title: Conditional survival and the prognostic value of serum carcinoembryonic antigen level
in oldest old with colorectal cancer
Version: 2 Date: 03 Apr 2023
Reviewer:  Rongbo Wen
Reviewer's report:
This manuscript used the SEER database to evaluate the conditional survival for the oldest-old
patients and the serum CEA level was a useful indication for the prediction of survival. The
study was well-organized and had clinical guidance for the management for the oldest-old CRC
patients. Here were the advices for this manuscript.
1. The language should be improve by the native English speakers for there were many grammar
mistakes.
2. The authors used the SEER database which was a American database, what were the results of
the conditional survival in the authors’ center? Could the authors provide the external validation
by using other data?
3. The author found that C-stage combining TNM stage was meaningful, but what about the
prediction accuracy for the other patients? If the C-stage was also meaningful in all patients, the
clinical meaning of C-stage in oldest-old patients would be doubted.
Please review this paper.
user
Title: Conditional survival and the prognostic value of serum carcinoembryonic antigen level
in oldest old with colorectal cancer
Version: 2 Date: 03 Apr 2023
Reviewer:  Rongbo Wen
Reviewer's report:
This manuscript used the SEER database to evaluate the conditional survival for the oldest-old
patients and the serum CEA level was a useful indication for the prediction of survival. The
study was well-organized and had clinical guidance for the management for the oldest-old CRC
patients. Here were the advices for this manuscript.
1. The language should be improve by the native English speakers for there were many grammar
mistakes.
2. The authors used the SEER database which was a American database, what were the results of
the conditional survival in the authors’ center? Could the authors provide the external validation
by using other data?
3. The author found that C-stage combining TNM stage was meaningful, but what about the
prediction accuracy for the other patients? If the C-stage was also meaningful in all patients, the
clinical meaning of C-stage in oldest-old patients would be doubted.
assistant