Reviewer's report
Title:Liver ENPP1 Protein Increases with Remission of Type 2 Diabetes after
Gastric Bypass Surgery
Version:2Date:9 November 2014
Reviewer: Katrina L Purcell
Reviewer's report:
Minor essential revisions
Information regarding the medication participants were taking pre and
post-surgery is important. This is because, Stefanovic et al. 2004 reported that
ectonucleotide pyrophosphatase phosphodiesterase 1 is increased in
lymphocytes from T2D patients, and this increase was reversed by metformin
treatment. The same group has also reported that ectonucleotide
pyrophosphatase phosphodiesterase 1 is elevated in insulin-resistant uremic
patients, and this elevated ectonucleotide pyrophosphatase phosphodiesterase 1
is reversed by erythropoietin therapy.
Stefanovic V, Antic S 2004 Plasma cell membrane glycoprotein 1 (PC-1): a
marker of insulin resistance in obesity, uremia and diabetes mellitus. Clin Lab
50:271–278
Stefanovic V, Antic S, Mitic-Zlatkovic M, Vlahovic P Reversal of increased
lymphocyte PC-1 activity in patients with type 2 diabetes treated with metformin.
Diabetes Metab Res Rev 1999 15:400–404
What were the reasons for repeat biopsy?
Is the promoter of ENPP1 gene glucose responsive?
Discretionary revisions:
It would be helpful to the reader to specify what your primary and secondary aims
of the paper are.
It would be helpful to define the dates defining the recruitment period.
Figures are neatly presented. Table 1 and 2 could be put into one table. Flow
diagram of study participants would be helpful. Headings of tables should be
consistent e.g. before RYGB mentioned in table 1 and before first liver biopsy
mentioned in table 2 and individuals at RYGB (initial liver biopsy) mentioned in
table 3.
Possible conclusion could be ‘this is natures way of making more insulin
available to suppress hyperglycaemia’.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Liver ENPP1 Protein Increases with Remission of Type 2 Diabetes after
Gastric Bypass Surgery
Version:2Date:9 November 2014
Reviewer: Katrina L Purcell
Reviewer's report:
Minor essential revisions
Information regarding the medication participants were taking pre and
post-surgery is important. This is because, Stefanovic et al. 2004 reported that
ectonucleotide pyrophosphatase phosphodiesterase 1 is increased in
lymphocytes from T2D patients, and this increase was reversed by metformin
treatment. The same group has also reported that ectonucleotide
pyrophosphatase phosphodiesterase 1 is elevated in insulin-resistant uremic
patients, and this elevated ectonucleotide pyrophosphatase phosphodiesterase 1
is reversed by erythropoietin therapy.
Stefanovic V, Antic S 2004 Plasma cell membrane glycoprotein 1 (PC-1): a
marker of insulin resistance in obesity, uremia and diabetes mellitus. Clin Lab
50:271–278
Stefanovic V, Antic S, Mitic-Zlatkovic M, Vlahovic P Reversal of increased
lymphocyte PC-1 activity in patients with type 2 diabetes treated with metformin.
Diabetes Metab Res Rev 1999 15:400–404
What were the reasons for repeat biopsy?
Is the promoter of ENPP1 gene glucose responsive?
Discretionary revisions:
It would be helpful to the reader to specify what your primary and secondary aims
of the paper are.
It would be helpful to define the dates defining the recruitment period.
Figures are neatly presented. Table 1 and 2 could be put into one table. Flow
diagram of study participants would be helpful. Headings of tables should be
consistent e.g. before RYGB mentioned in table 1 and before first liver biopsy
mentioned in table 2 and individuals at RYGB (initial liver biopsy) mentioned in
table 3.
Possible conclusion could be ‘this is natures way of making more insulin
available to suppress hyperglycaemia’.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Liver ENPP1 Protein Increases with Remission of Type 2 Diabetes after
Gastric Bypass Surgery
Version:2Date:9 November 2014
Reviewer: Katrina L Purcell
Reviewer's report:
Minor essential revisions
Information regarding the medication participants were taking pre and
post-surgery is important. This is because, Stefanovic et al. 2004 reported that
ectonucleotide pyrophosphatase phosphodiesterase 1 is increased in
lymphocytes from T2D patients, and this increase was reversed by metformin
treatment. The same group has also reported that ectonucleotide
pyrophosphatase phosphodiesterase 1 is elevated in insulin-resistant uremic
patients, and this elevated ectonucleotide pyrophosphatase phosphodiesterase 1
is reversed by erythropoietin therapy.
Stefanovic V, Antic S 2004 Plasma cell membrane glycoprotein 1 (PC-1): a
marker of insulin resistance in obesity, uremia and diabetes mellitus. Clin Lab
50:271–278
Stefanovic V, Antic S, Mitic-Zlatkovic M, Vlahovic P Reversal of increased
lymphocyte PC-1 activity in patients with type 2 diabetes treated with metformin.
Diabetes Metab Res Rev 1999 15:400–404
What were the reasons for repeat biopsy?
Is the promoter of ENPP1 gene glucose responsive?
Discretionary revisions:
It would be helpful to the reader to specify what your primary and secondary aims
of the paper are.
It would be helpful to define the dates defining the recruitment period.
Figures are neatly presented. Table 1 and 2 could be put into one table. Flow
diagram of study participants would be helpful. Headings of tables should be
consistent e.g. before RYGB mentioned in table 1 and before first liver biopsy
mentioned in table 2 and individuals at RYGB (initial liver biopsy) mentioned in
table 3.
Possible conclusion could be ‘this is natures way of making more insulin
available to suppress hyperglycaemia’.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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