Title: Association of Biological Aging and the Prevalence of Nonalcoholic Fatty Liver Disease:
a Population-based Study
Version: 0 Date: 18 Feb 2025
Reviewer's report:
The authors have evaluated the association of biological aging markers with NAFLD.
(1) The definition of NAFLD is based on exclusion criteria, those with underlying liver diseases
or significant alcohol intake should be excluded. What the authors have defined is hepatic
steatosis or steatotic liver disease.
(2) The approach is interesting, but it is not surprising  that biological aging markers are
associated with steatotic liver disease. If the authors have done Z-score normalization for 4
markers (AL, HD, KDM, phenoage), rank them, and discuss which one is most effective and
why, then this study would have significant novelty.
Title: Association of Biological Aging and the Prevalence of Nonalcoholic Fatty Liver Disease:
a Population-based Study
Version: 0 Date: 18 Feb 2025
Reviewer's report:
The authors have evaluated the association of biological aging markers with NAFLD.
(1) The definition of NAFLD is based on exclusion criteria, those with underlying liver diseases
or significant alcohol intake should be excluded. What the authors have defined is hepatic
steatosis or steatotic liver disease.
(2) The approach is interesting, but it is not surprising  that biological aging markers are
associated with steatotic liver disease. If the authors have done Z-score normalization for 4
markers (AL, HD, KDM, phenoage), rank them, and discuss which one is most effective and
why, then this study would have significant novelty.
Please review this paper.
user
Title: Association of Biological Aging and the Prevalence of Nonalcoholic Fatty Liver Disease:
a Population-based Study
Version: 0 Date: 18 Feb 2025
Reviewer's report:
The authors have evaluated the association of biological aging markers with NAFLD.
(1) The definition of NAFLD is based on exclusion criteria, those with underlying liver diseases
or significant alcohol intake should be excluded. What the authors have defined is hepatic
steatosis or steatotic liver disease.
(2) The approach is interesting, but it is not surprising  that biological aging markers are
associated with steatotic liver disease. If the authors have done Z-score normalization for 4
markers (AL, HD, KDM, phenoage), rank them, and discuss which one is most effective and
why, then this study would have significant novelty.
assistant