Reviewer's report
Title:Increased proportion of nitric oxide synthase immunoreactive neurons in
rat ileal myenteric ganglia after severe acute pancreatitis
Version: 8Date:13 September 2011
Reviewer: Colin R Anderson
Reviewer's report:
I am happy that the authors have complied with my requests by either altering
the manuscript or by clarifying some issues in their letter. I note only one further
issue, which their modified manuscript has made clear. The authors appear to
have statistically analysed percentages using t-tests. Percentages are binomial,
not normal, in distribution and so parametric statistical tests should not be used.
The alternatives are to use a Mann-Whitney nonparametric test, carry out an
arcsine transformation of the percentages before using t-tests or analysing the
raw data (mean number of cells per ganglion per animal in the two groups) by
t-test. Figure 4 also lacks error bars. Please also correct the spelling of
"preperation" (should be preparation) and "gouge" (gauge).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Increased proportion of nitric oxide synthase immunoreactive neurons in
rat ileal myenteric ganglia after severe acute pancreatitis
Version: 8Date:13 September 2011
Reviewer: Colin R Anderson
Reviewer's report:
I am happy that the authors have complied with my requests by either altering
the manuscript or by clarifying some issues in their letter. I note only one further
issue, which their modified manuscript has made clear. The authors appear to
have statistically analysed percentages using t-tests. Percentages are binomial,
not normal, in distribution and so parametric statistical tests should not be used.
The alternatives are to use a Mann-Whitney nonparametric test, carry out an
arcsine transformation of the percentages before using t-tests or analysing the
raw data (mean number of cells per ganglion per animal in the two groups) by
t-test. Figure 4 also lacks error bars. Please also correct the spelling of
"preperation" (should be preparation) and "gouge" (gauge).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Increased proportion of nitric oxide synthase immunoreactive neurons in
rat ileal myenteric ganglia after severe acute pancreatitis
Version: 8Date:13 September 2011
Reviewer: Colin R Anderson
Reviewer's report:
I am happy that the authors have complied with my requests by either altering
the manuscript or by clarifying some issues in their letter. I note only one further
issue, which their modified manuscript has made clear. The authors appear to
have statistically analysed percentages using t-tests. Percentages are binomial,
not normal, in distribution and so parametric statistical tests should not be used.
The alternatives are to use a Mann-Whitney nonparametric test, carry out an
arcsine transformation of the percentages before using t-tests or analysing the
raw data (mean number of cells per ganglion per animal in the two groups) by
t-test. Figure 4 also lacks error bars. Please also correct the spelling of
"preperation" (should be preparation) and "gouge" (gauge).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
assistant