Title: Research and experiments of a new premedication for improving mucosal visibility during
esophagogastroduodenoscopy
Version: 2 Date: 23 Feb 2025
Reviewer's report:
This study investigates the potential of food additives (FA-1, FA-2, FA-3) as premedications
for improving mucosal visibility during EGD, comparing their efficacy with conventional
agents (pronase, dimethicone). The topic is clinically relevant, and the experimental design
is systematic. However, several issues regarding methodological clarity, statistical rigor, and
discussion depth need to be addressed to enhance the manuscript's impact.
Major revision
1.The title should be rewrite to focus on premedications for improving mucosal visibility during
EGD#
2.For foaming model, detail parameters (e.g., air pump pressure, cylinder dimensions) and
validate the model’s relevance to in vivo conditions should be added. Further, in my opinion,
the model is simulation of the internal environment. In this way, the temperatures should be
set as 37##
3.For gastric juice experiment, they should clarify inclusion/exclusion criteria for patients and
describe gastric juice processing steps (e.g., centrifugation, storage temperature).
4.In my opinion, in vivo experiments or animal models are need.
5.What is the meaning and usefulness of outcome measures? I find no related results in the
manuscript.
6.For the effect of food additives in gastric juice experiment, there is no statistical analysis but
only figure.
7.The synergistic mechanism of FA-2/FA-3 with references to colloid chemistry or surfactant
theory should be research or discussed.
Minor revision
1.For FA-1, FA-2, and FA-3, they should give us why and how to choose these food additives.
2.Correct some grammatical errors (e.g., “clinical stage” # “clinical stages”).
Title: Research and experiments of a new premedication for improving mucosal visibility during
esophagogastroduodenoscopy
Version: 2 Date: 23 Feb 2025
Reviewer's report:
This study investigates the potential of food additives (FA-1, FA-2, FA-3) as premedications
for improving mucosal visibility during EGD, comparing their efficacy with conventional
agents (pronase, dimethicone). The topic is clinically relevant, and the experimental design
is systematic. However, several issues regarding methodological clarity, statistical rigor, and
discussion depth need to be addressed to enhance the manuscript's impact.
Major revision
1.The title should be rewrite to focus on premedications for improving mucosal visibility during
EGD#
2.For foaming model, detail parameters (e.g., air pump pressure, cylinder dimensions) and
validate the model’s relevance to in vivo conditions should be added. Further, in my opinion,
the model is simulation of the internal environment. In this way, the temperatures should be
set as 37##
3.For gastric juice experiment, they should clarify inclusion/exclusion criteria for patients and
describe gastric juice processing steps (e.g., centrifugation, storage temperature).
4.In my opinion, in vivo experiments or animal models are need.
5.What is the meaning and usefulness of outcome measures? I find no related results in the
manuscript.
6.For the effect of food additives in gastric juice experiment, there is no statistical analysis but
only figure.
7.The synergistic mechanism of FA-2/FA-3 with references to colloid chemistry or surfactant
theory should be research or discussed.
Minor revision
1.For FA-1, FA-2, and FA-3, they should give us why and how to choose these food additives.
2.Correct some grammatical errors (e.g., “clinical stage” # “clinical stages”).
Please review this paper.
user
Title: Research and experiments of a new premedication for improving mucosal visibility during
esophagogastroduodenoscopy
Version: 2 Date: 23 Feb 2025
Reviewer's report:
This study investigates the potential of food additives (FA-1, FA-2, FA-3) as premedications
for improving mucosal visibility during EGD, comparing their efficacy with conventional
agents (pronase, dimethicone). The topic is clinically relevant, and the experimental design
is systematic. However, several issues regarding methodological clarity, statistical rigor, and
discussion depth need to be addressed to enhance the manuscript's impact.
Major revision
1.The title should be rewrite to focus on premedications for improving mucosal visibility during
EGD#
2.For foaming model, detail parameters (e.g., air pump pressure, cylinder dimensions) and
validate the model’s relevance to in vivo conditions should be added. Further, in my opinion,
the model is simulation of the internal environment. In this way, the temperatures should be
set as 37##
3.For gastric juice experiment, they should clarify inclusion/exclusion criteria for patients and
describe gastric juice processing steps (e.g., centrifugation, storage temperature).
4.In my opinion, in vivo experiments or animal models are need.
5.What is the meaning and usefulness of outcome measures? I find no related results in the
manuscript.
6.For the effect of food additives in gastric juice experiment, there is no statistical analysis but
only figure.
7.The synergistic mechanism of FA-2/FA-3 with references to colloid chemistry or surfactant
theory should be research or discussed.
Minor revision
1.For FA-1, FA-2, and FA-3, they should give us why and how to choose these food additives.
2.Correct some grammatical errors (e.g., “clinical stage” # “clinical stages”).
assistant