Reviewer ’s report  
 
Title: A rare case of Epstein –Barr vir us-positive mucocutaneo us ulcer that developed into an 
intestinal obstruction  
 
Version: 0 Date: 05 Jul 2019  
 
Reviewer: Sungjae Shin  
 
Reviewer's report:  
 
Comments to Authors  
 
EBV -MCU is a new category of mature -B cell neoplasm and surgical resection by intestinal 
obstruction caused by EBV -MCU is rare. Therefore, this manuscript is very meaningful in this 
respect. The following additional pieces of information would make the rep ort even more 
convincing.  
 
 
Major comments  
 
1. There is a lot of repeated sentences in the thesis, and the context is not natural, so the 
whole English correction is necessary.  
 
2. In the discussion, Hodgkin lymphoma developed during follow -up in a patient o f Crohn 
disease with the EBV -MCU. But, there is a lack of explanation for association between 
the two diseases, so additional explanation is needed.  
 
3. After the first CT, authors decided to consider surgical resection, but instead of 
performing the surger y, the author observed the patient as CT scan follow -up. What is the 
reason? It is needed for additional explanation.  
 
 
Minor comments  
 
1. How long after the first CT was the second CT scan performed?  
 
2. The author mentioned that circumferential ulcer with tumors were found. But, no 
apparent ulcerative lesions were observed in this picture.  
 
3. Which area of the lesion is better for biopsy during colonoscopy to make accurate 
diagnosis (for example, ulcer margin vs. center)?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financially from the 
publi cation of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you curr ently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any  other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be incl uded 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: A rare case of Epstein –Barr vir us-positive mucocutaneo us ulcer that developed into an 
intestinal obstruction  
 
Version: 0 Date: 05 Jul 2019  
 
Reviewer: Sungjae Shin  
 
Reviewer's report:  
 
Comments to Authors  
 
EBV -MCU is a new category of mature -B cell neoplasm and surgical resection by intestinal 
obstruction caused by EBV -MCU is rare. Therefore, this manuscript is very meaningful in this 
respect. The following additional pieces of information would make the rep ort even more 
convincing.  
 
 
Major comments  
 
1. There is a lot of repeated sentences in the thesis, and the context is not natural, so the 
whole English correction is necessary.  
 
2. In the discussion, Hodgkin lymphoma developed during follow -up in a patient o f Crohn 
disease with the EBV -MCU. But, there is a lack of explanation for association between 
the two diseases, so additional explanation is needed.  
 
3. After the first CT, authors decided to consider surgical resection, but instead of 
performing the surger y, the author observed the patient as CT scan follow -up. What is the 
reason? It is needed for additional explanation.  
 
 
Minor comments  
 
1. How long after the first CT was the second CT scan performed?  
 
2. The author mentioned that circumferential ulcer with tumors were found. But, no 
apparent ulcerative lesions were observed in this picture.  
 
3. Which area of the lesion is better for biopsy during colonoscopy to make accurate 
diagnosis (for example, ulcer margin vs. center)?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financially from the 
publi cation of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you curr ently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any  other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be incl uded 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: A rare case of Epstein –Barr vir us-positive mucocutaneo us ulcer that developed into an 
intestinal obstruction  
 
Version: 0 Date: 05 Jul 2019  
 
Reviewer: Sungjae Shin  
 
Reviewer's report:  
 
Comments to Authors  
 
EBV -MCU is a new category of mature -B cell neoplasm and surgical resection by intestinal 
obstruction caused by EBV -MCU is rare. Therefore, this manuscript is very meaningful in this 
respect. The following additional pieces of information would make the rep ort even more 
convincing.  
 
 
Major comments  
 
1. There is a lot of repeated sentences in the thesis, and the context is not natural, so the 
whole English correction is necessary.  
 
2. In the discussion, Hodgkin lymphoma developed during follow -up in a patient o f Crohn 
disease with the EBV -MCU. But, there is a lack of explanation for association between 
the two diseases, so additional explanation is needed.  
 
3. After the first CT, authors decided to consider surgical resection, but instead of 
performing the surger y, the author observed the patient as CT scan follow -up. What is the 
reason? It is needed for additional explanation.  
 
 
Minor comments  
 
1. How long after the first CT was the second CT scan performed?  
 
2. The author mentioned that circumferential ulcer with tumors were found. But, no 
apparent ulcerative lesions were observed in this picture.  
 
3. Which area of the lesion is better for biopsy during colonoscopy to make accurate 
diagnosis (for example, ulcer margin vs. center)?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financially from the 
publi cation of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you curr ently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any  other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be incl uded 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant