Title: Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on
esophageal motility: a systematic review
Version: 3 Date: 09 Jan 2023
Reviewer:  Praveen Kumar-m
Reviewer's report:
The authors should provide a detailed explanation of the outcomes and adverse events that were
examined in the study.
They should also conduct a risk of bias assessment and include the relevant details in the
methodology and results sections.
The PDE-5 inhibitors that were studied should be listed.
It would be helpful to separate the studies that included healthy subjects from those that included
patients with esophageal disorders.
There are grammatical errors in the manuscript, such as "mgs" instead of "mg".
The outcomes, such as lower esophageal sphincter tone, contraction wave amplitude, and
residual pressure, should be explained in the methodology section.
Title: Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on
esophageal motility: a systematic review
Version: 3 Date: 09 Jan 2023
Reviewer:  Praveen Kumar-m
Reviewer's report:
The authors should provide a detailed explanation of the outcomes and adverse events that were
examined in the study.
They should also conduct a risk of bias assessment and include the relevant details in the
methodology and results sections.
The PDE-5 inhibitors that were studied should be listed.
It would be helpful to separate the studies that included healthy subjects from those that included
patients with esophageal disorders.
There are grammatical errors in the manuscript, such as "mgs" instead of "mg".
The outcomes, such as lower esophageal sphincter tone, contraction wave amplitude, and
residual pressure, should be explained in the methodology section.
Please review this paper.
user
Title: Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on
esophageal motility: a systematic review
Version: 3 Date: 09 Jan 2023
Reviewer:  Praveen Kumar-m
Reviewer's report:
The authors should provide a detailed explanation of the outcomes and adverse events that were
examined in the study.
They should also conduct a risk of bias assessment and include the relevant details in the
methodology and results sections.
The PDE-5 inhibitors that were studied should be listed.
It would be helpful to separate the studies that included healthy subjects from those that included
patients with esophageal disorders.
There are grammatical errors in the manuscript, such as "mgs" instead of "mg".
The outcomes, such as lower esophageal sphincter tone, contraction wave amplitude, and
residual pressure, should be explained in the methodology section.
assistant