Title: Association between serum iron status and the risk of colorectal cancer in US adults: a
cross-sectional analysis of NHANES 2001–2020
Version: 1 Date: 17 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Usually large polypoid lesions and Ca bowel tend to lose blood ( Diagnosis based on FIT or
FOBT) Thus there is no point to check anemia or low ferritin in close proximity to the diagnosis
of malignancy  Methods Covariates related to demographics and clinical data should be defined
Three grade stratification is not practical Authors should defined why they have selected it and
not a continious recording of contious variables Have they tried to overcome recalling bias by
using any objective data Statistics Sample size should be calculated ANOVA should be used
in comparison on non parametric variables with more than 2 stratification categories Definion
of time point ferittin was measured  should be defined One time point is not enough and time
distance should be adequate
Title: Association between serum iron status and the risk of colorectal cancer in US adults: a
cross-sectional analysis of NHANES 2001–2020
Version: 1 Date: 17 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Usually large polypoid lesions and Ca bowel tend to lose blood ( Diagnosis based on FIT or
FOBT) Thus there is no point to check anemia or low ferritin in close proximity to the diagnosis
of malignancy  Methods Covariates related to demographics and clinical data should be defined
Three grade stratification is not practical Authors should defined why they have selected it and
not a continious recording of contious variables Have they tried to overcome recalling bias by
using any objective data Statistics Sample size should be calculated ANOVA should be used
in comparison on non parametric variables with more than 2 stratification categories Definion
of time point ferittin was measured  should be defined One time point is not enough and time
distance should be adequate
Please review this paper.
user
Title: Association between serum iron status and the risk of colorectal cancer in US adults: a
cross-sectional analysis of NHANES 2001–2020
Version: 1 Date: 17 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Usually large polypoid lesions and Ca bowel tend to lose blood ( Diagnosis based on FIT or
FOBT) Thus there is no point to check anemia or low ferritin in close proximity to the diagnosis
of malignancy  Methods Covariates related to demographics and clinical data should be defined
Three grade stratification is not practical Authors should defined why they have selected it and
not a continious recording of contious variables Have they tried to overcome recalling bias by
using any objective data Statistics Sample size should be calculated ANOVA should be used
in comparison on non parametric variables with more than 2 stratification categories Definion
of time point ferittin was measured  should be defined One time point is not enough and time
distance should be adequate
assistant