Reviewer's report
Title:Lymphomatoid granulomatosis associated with azathioprine therapy in
Crohn disease.
Version:4Date:7 May 2014
Reviewer: Sunny Hei Wong
Reviewer's report:
It is a well written case report of clinical importance and broad interest to the
readers in the field. A few points to clarify regarding the case:
Comments (major revisions)
1. The patient has Crohn's disease for 6 years. How long has she been put on
azathioprine? Has the patient received any other immunosuppressant, or biologic
therapy?
2. What serological tests for EBV were done exactly? What sample was positive
for EBV PCR / viral titre tests? Please clarify
3. Please elaborate on the pathological diagnosis of LYG. Was there any
vascular infiltration? (Reference - Colby TV, Modern Pathology
2012;25,S39–S42).
4. The authors mentioned "gastrointestinal predominant LYG" but I do not see
any evidence of luminal involvement of LYG. Was there any recent colonoscopy
finding? Was there evidence of the bowel involvement that may account for the
GI symptoms (abdominal pain and bloating)? Was there any bleeding or motility
symptom? Please elaborate
Grammar / spelling (minor revision)
Line 30: It is most often occurs (delete "is")
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Lymphomatoid granulomatosis associated with azathioprine therapy in
Crohn disease.
Version:4Date:7 May 2014
Reviewer: Sunny Hei Wong
Reviewer's report:
It is a well written case report of clinical importance and broad interest to the
readers in the field. A few points to clarify regarding the case:
Comments (major revisions)
1. The patient has Crohn's disease for 6 years. How long has she been put on
azathioprine? Has the patient received any other immunosuppressant, or biologic
therapy?
2. What serological tests for EBV were done exactly? What sample was positive
for EBV PCR / viral titre tests? Please clarify
3. Please elaborate on the pathological diagnosis of LYG. Was there any
vascular infiltration? (Reference - Colby TV, Modern Pathology
2012;25,S39–S42).
4. The authors mentioned "gastrointestinal predominant LYG" but I do not see
any evidence of luminal involvement of LYG. Was there any recent colonoscopy
finding? Was there evidence of the bowel involvement that may account for the
GI symptoms (abdominal pain and bloating)? Was there any bleeding or motility
symptom? Please elaborate
Grammar / spelling (minor revision)
Line 30: It is most often occurs (delete "is")
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Lymphomatoid granulomatosis associated with azathioprine therapy in
Crohn disease.
Version:4Date:7 May 2014
Reviewer: Sunny Hei Wong
Reviewer's report:
It is a well written case report of clinical importance and broad interest to the
readers in the field. A few points to clarify regarding the case:
Comments (major revisions)
1. The patient has Crohn's disease for 6 years. How long has she been put on
azathioprine? Has the patient received any other immunosuppressant, or biologic
therapy?
2. What serological tests for EBV were done exactly? What sample was positive
for EBV PCR / viral titre tests? Please clarify
3. Please elaborate on the pathological diagnosis of LYG. Was there any
vascular infiltration? (Reference - Colby TV, Modern Pathology
2012;25,S39–S42).
4. The authors mentioned "gastrointestinal predominant LYG" but I do not see
any evidence of luminal involvement of LYG. Was there any recent colonoscopy
finding? Was there evidence of the bowel involvement that may account for the
GI symptoms (abdominal pain and bloating)? Was there any bleeding or motility
symptom? Please elaborate
Grammar / spelling (minor revision)
Line 30: It is most often occurs (delete "is")
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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