Reviewer's report
Title:IL-6, through p-STAT3 rather than p-STAT1, activates
hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients
Version:3Date:26 August 2014
Reviewer: Suguru Yamada
Reviewer's report:
1. Through the manuscript, the authors described all of the results including the
detailed statistical values. Therefore, it is a little bit difficult to understand the
results. Perhaps, it is recommended that the important and significant values
should be chosen in the manuscript.
2. It is easy to understand the correlation among IL-6, IL-27 and TNF-# as
inflammatory cytokine, but VEGF should be another factor in carcinogenesis. The
detailed description regarding the reason why the authors chosen this VEGF in
this study.
3. In page 8, line 48, “anti- anti-HCV” is incorrect.
4. As for the immunostain scoring, please add the citation the author referred in
this study.
5. It is very difficult to understand why the authors used “6-month mortality” for
analysis. 6-month as a term is too short in regard to the clinics and survival, the
authors should perform another analysis for the survival.
6. Figure 5 should be removed.
Minor Essential Revisions
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have nothing to declare in this paper.
Reviewer's report
Title:IL-6, through p-STAT3 rather than p-STAT1, activates
hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients
Version:3Date:26 August 2014
Reviewer: Suguru Yamada
Reviewer's report:
1. Through the manuscript, the authors described all of the results including the
detailed statistical values. Therefore, it is a little bit difficult to understand the
results. Perhaps, it is recommended that the important and significant values
should be chosen in the manuscript.
2. It is easy to understand the correlation among IL-6, IL-27 and TNF-# as
inflammatory cytokine, but VEGF should be another factor in carcinogenesis. The
detailed description regarding the reason why the authors chosen this VEGF in
this study.
3. In page 8, line 48, “anti- anti-HCV” is incorrect.
4. As for the immunostain scoring, please add the citation the author referred in
this study.
5. It is very difficult to understand why the authors used “6-month mortality” for
analysis. 6-month as a term is too short in regard to the clinics and survival, the
authors should perform another analysis for the survival.
6. Figure 5 should be removed.
Minor Essential Revisions
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have nothing to declare in this paper.
Please review this paper.
user
Reviewer's report
Title:IL-6, through p-STAT3 rather than p-STAT1, activates
hepatocarcinogenesis and affects survival of hepatocellular carcinoma patients
Version:3Date:26 August 2014
Reviewer: Suguru Yamada
Reviewer's report:
1. Through the manuscript, the authors described all of the results including the
detailed statistical values. Therefore, it is a little bit difficult to understand the
results. Perhaps, it is recommended that the important and significant values
should be chosen in the manuscript.
2. It is easy to understand the correlation among IL-6, IL-27 and TNF-# as
inflammatory cytokine, but VEGF should be another factor in carcinogenesis. The
detailed description regarding the reason why the authors chosen this VEGF in
this study.
3. In page 8, line 48, “anti- anti-HCV” is incorrect.
4. As for the immunostain scoring, please add the citation the author referred in
this study.
5. It is very difficult to understand why the authors used “6-month mortality” for
analysis. 6-month as a term is too short in regard to the clinics and survival, the
authors should perform another analysis for the survival.
6. Figure 5 should be removed.
Minor Essential Revisions
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have nothing to declare in this paper.
assistant