Reviewer's report
Title:Early stage signet ring cell carcinoma of the colon examined by magnifying
endoscopy with narrow-band imaging: a case report
Version:2Date:6 May 2015
Reviewer: Ying Yuan
Reviewer's report:
Major Compulsory Revisions
1. Signet ring cell carcinoma of colon is rare, and early stage is even more
unusual. This case presented an early stage primary signet ring cell carcinoma of
cecum, which is really rare. Additionally, this case had a history of early gastric
cancer six years ago. This double primary cancer patient may have some kind of
gene defect or heredity disease. If possible, the family history should provide,
may it be a case of HNPCC?
2. You can also take some relative gene test, such as STK11, P53, CHEK2,
APC, BRCA1, CDH1(or E-cadherin) et al, to find out whether this patient have
gene defect or not, or other syndrome?
3. The technology of magnifying endoscopy with NBI and crystal violet staining
has been commonly used in clinical practice for several years. Though this case
provided the features under NBI magnifying endoscopy, the findings of signet
ring cell carcinoma of colon are similar to those of gastric signet ring cell
carcinoma. So the describe of technological finding should not be so important,
you could cut down some.
4. The diagnostic and treatment process of this case did not conformed to the
guidelines. Once a lesion was seen under the endoscopy, the biopsy was the
first step and pathologic diagnosis should be confirmed firstly. No matter the
carcinoma was confined in the mucosal layer or not, ESD was not recommended
for colon cancer in NCCN guidelines. A radical resection should be suggested.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Early stage signet ring cell carcinoma of the colon examined by magnifying
endoscopy with narrow-band imaging: a case report
Version:2Date:6 May 2015
Reviewer: Ying Yuan
Reviewer's report:
Major Compulsory Revisions
1. Signet ring cell carcinoma of colon is rare, and early stage is even more
unusual. This case presented an early stage primary signet ring cell carcinoma of
cecum, which is really rare. Additionally, this case had a history of early gastric
cancer six years ago. This double primary cancer patient may have some kind of
gene defect or heredity disease. If possible, the family history should provide,
may it be a case of HNPCC?
2. You can also take some relative gene test, such as STK11, P53, CHEK2,
APC, BRCA1, CDH1(or E-cadherin) et al, to find out whether this patient have
gene defect or not, or other syndrome?
3. The technology of magnifying endoscopy with NBI and crystal violet staining
has been commonly used in clinical practice for several years. Though this case
provided the features under NBI magnifying endoscopy, the findings of signet
ring cell carcinoma of colon are similar to those of gastric signet ring cell
carcinoma. So the describe of technological finding should not be so important,
you could cut down some.
4. The diagnostic and treatment process of this case did not conformed to the
guidelines. Once a lesion was seen under the endoscopy, the biopsy was the
first step and pathologic diagnosis should be confirmed firstly. No matter the
carcinoma was confined in the mucosal layer or not, ESD was not recommended
for colon cancer in NCCN guidelines. A radical resection should be suggested.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Early stage signet ring cell carcinoma of the colon examined by magnifying
endoscopy with narrow-band imaging: a case report
Version:2Date:6 May 2015
Reviewer: Ying Yuan
Reviewer's report:
Major Compulsory Revisions
1. Signet ring cell carcinoma of colon is rare, and early stage is even more
unusual. This case presented an early stage primary signet ring cell carcinoma of
cecum, which is really rare. Additionally, this case had a history of early gastric
cancer six years ago. This double primary cancer patient may have some kind of
gene defect or heredity disease. If possible, the family history should provide,
may it be a case of HNPCC?
2. You can also take some relative gene test, such as STK11, P53, CHEK2,
APC, BRCA1, CDH1(or E-cadherin) et al, to find out whether this patient have
gene defect or not, or other syndrome?
3. The technology of magnifying endoscopy with NBI and crystal violet staining
has been commonly used in clinical practice for several years. Though this case
provided the features under NBI magnifying endoscopy, the findings of signet
ring cell carcinoma of colon are similar to those of gastric signet ring cell
carcinoma. So the describe of technological finding should not be so important,
you could cut down some.
4. The diagnostic and treatment process of this case did not conformed to the
guidelines. Once a lesion was seen under the endoscopy, the biopsy was the
first step and pathologic diagnosis should be confirmed firstly. No matter the
carcinoma was confined in the mucosal layer or not, ESD was not recommended
for colon cancer in NCCN guidelines. A radical resection should be suggested.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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