Reviewer's report
Title:Dumping syndrome following Nissen fundoplication in an adult patient
diagnosed By BreathID continuous online 13C-octanoide acid breath test a case
report.
Version: 2Date:10 December 2010
Reviewer: Simon Eaton
Reviewer's report:
The authors have satisfactorily responded to some of the reviewers comments,
but not all of them.
The following points still require attention before the paper is suitable for
publication.
(i) if you are an introducing a new diagnostic test, it is not satisfactory to refer to
normal ranges obtained using a completely different methodology (ie. discrete
time point measurements of 13C-enrichment by Ghoos et al.). Using someone
else's normal range using a different test meal and a different measurement
method is inappropriate. Normal ranges for t1/2 etc. must be provided measured
by the Breath-ID using the same test meal and protocol.
(ii) the authors have chosen not to respond to my comments about the use of
Breath_ID in the title, or to the quality of the figure. The figure is still of too poor
quality for publication and must be re-drawn. "Continuous online 13C/12C
monitoring" is more informative than "Breath-ID" in the title; otherwise the paper
looks like an advertisement for BreathiID rather than a scientific contribution to
the literature.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Dumping syndrome following Nissen fundoplication in an adult patient
diagnosed By BreathID continuous online 13C-octanoide acid breath test a case
report.
Version: 2Date:10 December 2010
Reviewer: Simon Eaton
Reviewer's report:
The authors have satisfactorily responded to some of the reviewers comments,
but not all of them.
The following points still require attention before the paper is suitable for
publication.
(i) if you are an introducing a new diagnostic test, it is not satisfactory to refer to
normal ranges obtained using a completely different methodology (ie. discrete
time point measurements of 13C-enrichment by Ghoos et al.). Using someone
else's normal range using a different test meal and a different measurement
method is inappropriate. Normal ranges for t1/2 etc. must be provided measured
by the Breath-ID using the same test meal and protocol.
(ii) the authors have chosen not to respond to my comments about the use of
Breath_ID in the title, or to the quality of the figure. The figure is still of too poor
quality for publication and must be re-drawn. "Continuous online 13C/12C
monitoring" is more informative than "Breath-ID" in the title; otherwise the paper
looks like an advertisement for BreathiID rather than a scientific contribution to
the literature.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Dumping syndrome following Nissen fundoplication in an adult patient
diagnosed By BreathID continuous online 13C-octanoide acid breath test a case
report.
Version: 2Date:10 December 2010
Reviewer: Simon Eaton
Reviewer's report:
The authors have satisfactorily responded to some of the reviewers comments,
but not all of them.
The following points still require attention before the paper is suitable for
publication.
(i) if you are an introducing a new diagnostic test, it is not satisfactory to refer to
normal ranges obtained using a completely different methodology (ie. discrete
time point measurements of 13C-enrichment by Ghoos et al.). Using someone
else's normal range using a different test meal and a different measurement
method is inappropriate. Normal ranges for t1/2 etc. must be provided measured
by the Breath-ID using the same test meal and protocol.
(ii) the authors have chosen not to respond to my comments about the use of
Breath_ID in the title, or to the quality of the figure. The figure is still of too poor
quality for publication and must be re-drawn. "Continuous online 13C/12C
monitoring" is more informative than "Breath-ID" in the title; otherwise the paper
looks like an advertisement for BreathiID rather than a scientific contribution to
the literature.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant