Reviewer’s report
Title: Prognoses of different pathological subtypes of colorectal cancer at different stages: A 
population-based retrospective cohort study
Version: 0 Date: 23 Jul 2019
Reviewer: Takuma Higurashi
Reviewer's report:
This population-based retrospective cohort study concluded that the patients of different pathological 
subtypes were only minimally different at the early stage. However, they were significantly different 
prognosis and patients with MAC and SRCC have worse OS and CCS, which are mainly in advanced 
CRC (stages III and IV).
This is well written study and novel information, however, this study has some limitations in the 
following areas.
 
<Major＞
1. One of the strength of this study is large sample, however, excluded people are too many. The study 
that contains many excluded may have some biases. The authors should minimize the exclusion.
<Minor>
1.  The manuscript needs editing by a native English speaker.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1.Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation  that  may  in  any  way  gain  or  lose  financially  from  the  publication  of  this
manuscript, either now or in the future?
2.Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3.Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4.Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5.Do you have any other financial competing interests?
6.Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative Commons
CC-BY license (http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments
which I do not wish to be included in my named report can be included as confidential comments
to the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’s report
Title: Prognoses of different pathological subtypes of colorectal cancer at different stages: A 
population-based retrospective cohort study
Version: 0 Date: 23 Jul 2019
Reviewer: Takuma Higurashi
Reviewer's report:
This population-based retrospective cohort study concluded that the patients of different pathological 
subtypes were only minimally different at the early stage. However, they were significantly different 
prognosis and patients with MAC and SRCC have worse OS and CCS, which are mainly in advanced 
CRC (stages III and IV).
This is well written study and novel information, however, this study has some limitations in the 
following areas.
 
<Major＞
1. One of the strength of this study is large sample, however, excluded people are too many. The study 
that contains many excluded may have some biases. The authors should minimize the exclusion.
<Minor>
1.  The manuscript needs editing by a native English speaker.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1.Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation  that  may  in  any  way  gain  or  lose  financially  from  the  publication  of  this
manuscript, either now or in the future?
2.Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3.Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4.Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5.Do you have any other financial competing interests?
6.Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative Commons
CC-BY license (http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments
which I do not wish to be included in my named report can be included as confidential comments
to the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’s report
Title: Prognoses of different pathological subtypes of colorectal cancer at different stages: A 
population-based retrospective cohort study
Version: 0 Date: 23 Jul 2019
Reviewer: Takuma Higurashi
Reviewer's report:
This population-based retrospective cohort study concluded that the patients of different pathological 
subtypes were only minimally different at the early stage. However, they were significantly different 
prognosis and patients with MAC and SRCC have worse OS and CCS, which are mainly in advanced 
CRC (stages III and IV).
This is well written study and novel information, however, this study has some limitations in the 
following areas.
 
<Major＞
1. One of the strength of this study is large sample, however, excluded people are too many. The study 
that contains many excluded may have some biases. The authors should minimize the exclusion.
<Minor>
1.  The manuscript needs editing by a native English speaker.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1.Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation  that  may  in  any  way  gain  or  lose  financially  from  the  publication  of  this
manuscript, either now or in the future?
2.Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3.Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4.Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5.Do you have any other financial competing interests?
6.Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative Commons
CC-BY license (http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments
which I do not wish to be included in my named report can be included as confidential comments
to the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant