Title: Clinical significance of reactive thrombocytosis in the course of acute pancreatitis
Version: 1 Date: 10 Apr 2023
Reviewer's report:
1. Line 65-66 The authors mentioned “Accordingly, abnormalities of factors involved in
inflammation and disorders of cellular immunity have been reported[7-10].” The authors should
add which disease cause abnormalities of factors involved in inflammation and disorders of
cellular immunity in the sentence.
2. Line 120-121 The authors wrote “when the total prognostic factor score was 3 points or more
or the computed tomography (CT) grade was 2 or more”. I think the sentence is incomplete.
When the total prognostic factor score was 3 points or more or the computed tomography (CT)
grade was 2 or more, what did it defined?
3. Line 145-149 The authors wrote “the thrombocytopenia group was defined as those with
platelet counts of less than 100,000/µL for two or more consecutive days, the thrombocytosis
group as those with platelet counts of 450,000/µL or more, and the normal platelet count group
as the remaining patients.” And in table 2, title is “Comparison of patients with acute pancreatitis
in different platelet count groups at admission”. How was platelet count group exactly defined?
Just looking at title of table 2, groups seem to be divided based on platelet count on admission.
However, line 145-149 states groups were divided based on results of platelet count for two or
more consecutive days. How were the groups divided? Based on platelet count from admission
to two or more consecutive days? Or based on from abnormal result of platelet count to two or
more consecutive days during admission period?
Title: Clinical significance of reactive thrombocytosis in the course of acute pancreatitis
Version: 1 Date: 10 Apr 2023
Reviewer's report:
1. Line 65-66 The authors mentioned “Accordingly, abnormalities of factors involved in
inflammation and disorders of cellular immunity have been reported[7-10].” The authors should
add which disease cause abnormalities of factors involved in inflammation and disorders of
cellular immunity in the sentence.
2. Line 120-121 The authors wrote “when the total prognostic factor score was 3 points or more
or the computed tomography (CT) grade was 2 or more”. I think the sentence is incomplete.
When the total prognostic factor score was 3 points or more or the computed tomography (CT)
grade was 2 or more, what did it defined?
3. Line 145-149 The authors wrote “the thrombocytopenia group was defined as those with
platelet counts of less than 100,000/µL for two or more consecutive days, the thrombocytosis
group as those with platelet counts of 450,000/µL or more, and the normal platelet count group
as the remaining patients.” And in table 2, title is “Comparison of patients with acute pancreatitis
in different platelet count groups at admission”. How was platelet count group exactly defined?
Just looking at title of table 2, groups seem to be divided based on platelet count on admission.
However, line 145-149 states groups were divided based on results of platelet count for two or
more consecutive days. How were the groups divided? Based on platelet count from admission
to two or more consecutive days? Or based on from abnormal result of platelet count to two or
more consecutive days during admission period?
Please review this paper.
user
Title: Clinical significance of reactive thrombocytosis in the course of acute pancreatitis
Version: 1 Date: 10 Apr 2023
Reviewer's report:
1. Line 65-66 The authors mentioned “Accordingly, abnormalities of factors involved in
inflammation and disorders of cellular immunity have been reported[7-10].” The authors should
add which disease cause abnormalities of factors involved in inflammation and disorders of
cellular immunity in the sentence.
2. Line 120-121 The authors wrote “when the total prognostic factor score was 3 points or more
or the computed tomography (CT) grade was 2 or more”. I think the sentence is incomplete.
When the total prognostic factor score was 3 points or more or the computed tomography (CT)
grade was 2 or more, what did it defined?
3. Line 145-149 The authors wrote “the thrombocytopenia group was defined as those with
platelet counts of less than 100,000/µL for two or more consecutive days, the thrombocytosis
group as those with platelet counts of 450,000/µL or more, and the normal platelet count group
as the remaining patients.” And in table 2, title is “Comparison of patients with acute pancreatitis
in different platelet count groups at admission”. How was platelet count group exactly defined?
Just looking at title of table 2, groups seem to be divided based on platelet count on admission.
However, line 145-149 states groups were divided based on results of platelet count for two or
more consecutive days. How were the groups divided? Based on platelet count from admission
to two or more consecutive days? Or based on from abnormal result of platelet count to two or
more consecutive days during admission period?
assistant