Reviewer's report
Title:Independent association of HbA1c and nonalcoholic fatty liver disease in
an elderly Chinese population
Version: 1Date:11 September 2012
Reviewer: Yue Wang
Reviewer's report:
This cross-sectional study aimed to analysis the association of HbA1c with
NAFLD in an elderly Chinese population. The authors observed a significant
increase of HbA1c levels in NAFLD patients, and regression analysis showed
that increased serum HbA1c level was an independent risk factor for NAFLD.
The goal and the importance of this work are clearly stated. The data is well
presented and well argued. It is a well construed study and may be valuable for
publication after minor revision, my comments are list below.
1. The population studied includes retired employees of one company alone.
Whether this could be a representative sample of the elderly Chinese population
remains to be ascertained.
2. Most readers will not be familiar with the ultrasound diagnostic criteria
established by the Chinese Liver Disease Association for NAFLD. If it is not too
lengthy, the authors should summarize this and put the criteria in the text. This
will help the readers to understand how to diagnosis has been made.
3. It is not clear how the stepwise multivariate analysis was carried out. How
were covariates selected for inclusion and exclusion from the model?
4. A recent reference regarding prevalence and risk factors of NAFLD in the
elderly should be added:
- EM Koehler, et al. Prevalence and risk factors of non-alcoholic fatty liver
disease in the elderly: Results from the Rotterdam study. Journal of Hepatology,
in press.
5. Table 2 should include the units of the variables.
6. There are minor problems with English language.
7. Abbreviations should be explained when first used.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
i have no competing interests in relation to this paper
Reviewer's report
Title:Independent association of HbA1c and nonalcoholic fatty liver disease in
an elderly Chinese population
Version: 1Date:11 September 2012
Reviewer: Yue Wang
Reviewer's report:
This cross-sectional study aimed to analysis the association of HbA1c with
NAFLD in an elderly Chinese population. The authors observed a significant
increase of HbA1c levels in NAFLD patients, and regression analysis showed
that increased serum HbA1c level was an independent risk factor for NAFLD.
The goal and the importance of this work are clearly stated. The data is well
presented and well argued. It is a well construed study and may be valuable for
publication after minor revision, my comments are list below.
1. The population studied includes retired employees of one company alone.
Whether this could be a representative sample of the elderly Chinese population
remains to be ascertained.
2. Most readers will not be familiar with the ultrasound diagnostic criteria
established by the Chinese Liver Disease Association for NAFLD. If it is not too
lengthy, the authors should summarize this and put the criteria in the text. This
will help the readers to understand how to diagnosis has been made.
3. It is not clear how the stepwise multivariate analysis was carried out. How
were covariates selected for inclusion and exclusion from the model?
4. A recent reference regarding prevalence and risk factors of NAFLD in the
elderly should be added:
- EM Koehler, et al. Prevalence and risk factors of non-alcoholic fatty liver
disease in the elderly: Results from the Rotterdam study. Journal of Hepatology,
in press.
5. Table 2 should include the units of the variables.
6. There are minor problems with English language.
7. Abbreviations should be explained when first used.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
i have no competing interests in relation to this paper
Please review this paper.
user
Reviewer's report
Title:Independent association of HbA1c and nonalcoholic fatty liver disease in
an elderly Chinese population
Version: 1Date:11 September 2012
Reviewer: Yue Wang
Reviewer's report:
This cross-sectional study aimed to analysis the association of HbA1c with
NAFLD in an elderly Chinese population. The authors observed a significant
increase of HbA1c levels in NAFLD patients, and regression analysis showed
that increased serum HbA1c level was an independent risk factor for NAFLD.
The goal and the importance of this work are clearly stated. The data is well
presented and well argued. It is a well construed study and may be valuable for
publication after minor revision, my comments are list below.
1. The population studied includes retired employees of one company alone.
Whether this could be a representative sample of the elderly Chinese population
remains to be ascertained.
2. Most readers will not be familiar with the ultrasound diagnostic criteria
established by the Chinese Liver Disease Association for NAFLD. If it is not too
lengthy, the authors should summarize this and put the criteria in the text. This
will help the readers to understand how to diagnosis has been made.
3. It is not clear how the stepwise multivariate analysis was carried out. How
were covariates selected for inclusion and exclusion from the model?
4. A recent reference regarding prevalence and risk factors of NAFLD in the
elderly should be added:
- EM Koehler, et al. Prevalence and risk factors of non-alcoholic fatty liver
disease in the elderly: Results from the Rotterdam study. Journal of Hepatology,
in press.
5. Table 2 should include the units of the variables.
6. There are minor problems with English language.
7. Abbreviations should be explained when first used.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
i have no competing interests in relation to this paper
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