Reviewer ’s report  
 
Title: Increased Incidence of Metachronous Gastric Neoplasm After Endoscopic Resection in  
Patients With Synchronous Gastric Neoplasm  
 
Version: 1 Date: 28 Mar 2020  
 
Reviewer: Satoki Shichijo  
 
Reviewer's report:  
 
This article is retrospective study which investigated the incidence of metachronous gastric 
neoplasm after endoscopic resection. It is an interesting study, but there are several concerns to 
be raised.  
 
1. Pathological diagnosis was based on the Vienna classification. How was the mucosal cancer, 
i.e., high grade dysplasia was treated? Please clarify this point.  
 
2. There are several reports that severe endoscopic atrophy was risk for metachronous gastric 
cancer.(Hanaoka, Uedo et al. 2010, Mori, Nakajima et al. 2015) Discuss the difference between 
the present study and the previous reports.  
 
3. Authors conclude that strict follow -up is important for patients after endoscopic resection with 
synchronous gastric neoplasm. Show cases that needed surgery or lead to death by metachronous 
gastric neoplasm in the entire cohort.  
 
4. Professional Englis h textcheck is mandatory.  
 
References.  
Hanaoka, N., et al. (2010). "Autofluorescence imaging for predicting development of 
metachronous gastric cancer after Helicobacter pylori eradication." J Gastroenterol Hepatol 
25(12): 1844 -1849.  
  
Mori, G., et al. (20 15). "Incidence of and risk factors for metachronous gastric cancer after 
endoscopic resection and successful Helicobacter pylori eradication: results of a large -scale, 
multicenter cohort study in Japan." Gastric Cancer.  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your c omments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in yo ur comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in y our comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named rep ort 
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understa nd that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Increased Incidence of Metachronous Gastric Neoplasm After Endoscopic Resection in  
Patients With Synchronous Gastric Neoplasm  
 
Version: 1 Date: 28 Mar 2020  
 
Reviewer: Satoki Shichijo  
 
Reviewer's report:  
 
This article is retrospective study which investigated the incidence of metachronous gastric 
neoplasm after endoscopic resection. It is an interesting study, but there are several concerns to 
be raised.  
 
1. Pathological diagnosis was based on the Vienna classification. How was the mucosal cancer, 
i.e., high grade dysplasia was treated? Please clarify this point.  
 
2. There are several reports that severe endoscopic atrophy was risk for metachronous gastric 
cancer.(Hanaoka, Uedo et al. 2010, Mori, Nakajima et al. 2015) Discuss the difference between 
the present study and the previous reports.  
 
3. Authors conclude that strict follow -up is important for patients after endoscopic resection with 
synchronous gastric neoplasm. Show cases that needed surgery or lead to death by metachronous 
gastric neoplasm in the entire cohort.  
 
4. Professional Englis h textcheck is mandatory.  
 
References.  
Hanaoka, N., et al. (2010). "Autofluorescence imaging for predicting development of 
metachronous gastric cancer after Helicobacter pylori eradication." J Gastroenterol Hepatol 
25(12): 1844 -1849.  
  
Mori, G., et al. (20 15). "Incidence of and risk factors for metachronous gastric cancer after 
endoscopic resection and successful Helicobacter pylori eradication: results of a large -scale, 
multicenter cohort study in Japan." Gastric Cancer.  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your c omments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in yo ur comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in y our comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named rep ort 
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understa nd that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Increased Incidence of Metachronous Gastric Neoplasm After Endoscopic Resection in  
Patients With Synchronous Gastric Neoplasm  
 
Version: 1 Date: 28 Mar 2020  
 
Reviewer: Satoki Shichijo  
 
Reviewer's report:  
 
This article is retrospective study which investigated the incidence of metachronous gastric 
neoplasm after endoscopic resection. It is an interesting study, but there are several concerns to 
be raised.  
 
1. Pathological diagnosis was based on the Vienna classification. How was the mucosal cancer, 
i.e., high grade dysplasia was treated? Please clarify this point.  
 
2. There are several reports that severe endoscopic atrophy was risk for metachronous gastric 
cancer.(Hanaoka, Uedo et al. 2010, Mori, Nakajima et al. 2015) Discuss the difference between 
the present study and the previous reports.  
 
3. Authors conclude that strict follow -up is important for patients after endoscopic resection with 
synchronous gastric neoplasm. Show cases that needed surgery or lead to death by metachronous 
gastric neoplasm in the entire cohort.  
 
4. Professional Englis h textcheck is mandatory.  
 
References.  
Hanaoka, N., et al. (2010). "Autofluorescence imaging for predicting development of 
metachronous gastric cancer after Helicobacter pylori eradication." J Gastroenterol Hepatol 
25(12): 1844 -1849.  
  
Mori, G., et al. (20 15). "Incidence of and risk factors for metachronous gastric cancer after 
endoscopic resection and successful Helicobacter pylori eradication: results of a large -scale, 
multicenter cohort study in Japan." Gastric Cancer.  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your c omments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in yo ur comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in y our comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named rep ort 
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understa nd that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant