Reviewer's report
Title:Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor,
alleviates liver injury induced by acetaminophen overdose in mice
Version: 4Date:11 December 2012
Reviewer: Thomas Schreiter
Reviewer's report:
In the revised form of the manuscript “Ozagrel hydrochloride, a selective
thromboxane A2 synthase inhibitor, alleviates liver injury induced by
acetaminophen overdose in mice” all major revisions have been addressed
properly by the authors.
Nevertheless, this reviewer found one discrepancy in the Legend of Figure 1B:
The reviewer suggested “… mice were treated with ozagrel (200mg/ml, n=5) or
saline (n=11) 30 min after APAP injection (n=16, might be omitted)… “.
The authors changed to “… mice were treated with ozagrel (200mg/ml, n=5) or
saline 30 min after APAP injection (n=11) … “. If the total number of mice was 11,
the number of saline treated mice would have been six, but there are eight data
points in the graph. This should be adjusted.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor,
alleviates liver injury induced by acetaminophen overdose in mice
Version: 4Date:11 December 2012
Reviewer: Thomas Schreiter
Reviewer's report:
In the revised form of the manuscript “Ozagrel hydrochloride, a selective
thromboxane A2 synthase inhibitor, alleviates liver injury induced by
acetaminophen overdose in mice” all major revisions have been addressed
properly by the authors.
Nevertheless, this reviewer found one discrepancy in the Legend of Figure 1B:
The reviewer suggested “… mice were treated with ozagrel (200mg/ml, n=5) or
saline (n=11) 30 min after APAP injection (n=16, might be omitted)… “.
The authors changed to “… mice were treated with ozagrel (200mg/ml, n=5) or
saline 30 min after APAP injection (n=11) … “. If the total number of mice was 11,
the number of saline treated mice would have been six, but there are eight data
points in the graph. This should be adjusted.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Ozagrel hydrochloride, a selective thromboxane A2 synthase inhibitor,
alleviates liver injury induced by acetaminophen overdose in mice
Version: 4Date:11 December 2012
Reviewer: Thomas Schreiter
Reviewer's report:
In the revised form of the manuscript “Ozagrel hydrochloride, a selective
thromboxane A2 synthase inhibitor, alleviates liver injury induced by
acetaminophen overdose in mice” all major revisions have been addressed
properly by the authors.
Nevertheless, this reviewer found one discrepancy in the Legend of Figure 1B:
The reviewer suggested “… mice were treated with ozagrel (200mg/ml, n=5) or
saline (n=11) 30 min after APAP injection (n=16, might be omitted)… “.
The authors changed to “… mice were treated with ozagrel (200mg/ml, n=5) or
saline 30 min after APAP injection (n=11) … “. If the total number of mice was 11,
the number of saline treated mice would have been six, but there are eight data
points in the graph. This should be adjusted.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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