Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 0 Date: 24 Jun 2024
Reviewer's report:
I found Zhang et al’s paper on the Associations between Life’s Essential 8 and the Prognosis of
Alcoholic Liver disease to be very interesting and well written. I found the topic relevant and
the statistical analysis to be robust. I am eager to see how if improving LE8 could improve CV
mortality in this patient population.
I have only a few comments:
1. I recommend the authors update their use of the term “alcoholic” to “alcohol related” or
“alcohol associated.”
2. According to the supplementary information, the ALD patients were included if liver enzymes
were elevated in the setting of significant alcohol intake. Please specify whether other liver
diseases were  excluded in these patients? Also, cirrhosis can occur in the setting of normal liver
enzymes. Were patients with chronic liver disease but normal liver enzymes also included in
the analysis?
3. Because readers may not be familiar with the LE 8 score, I suggest including the exact scoring
system.
I look forward to reading the final version of this interesting paper.
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 0 Date: 24 Jun 2024
Reviewer's report:
I found Zhang et al’s paper on the Associations between Life’s Essential 8 and the Prognosis of
Alcoholic Liver disease to be very interesting and well written. I found the topic relevant and
the statistical analysis to be robust. I am eager to see how if improving LE8 could improve CV
mortality in this patient population.
I have only a few comments:
1. I recommend the authors update their use of the term “alcoholic” to “alcohol related” or
“alcohol associated.”
2. According to the supplementary information, the ALD patients were included if liver enzymes
were elevated in the setting of significant alcohol intake. Please specify whether other liver
diseases were  excluded in these patients? Also, cirrhosis can occur in the setting of normal liver
enzymes. Were patients with chronic liver disease but normal liver enzymes also included in
the analysis?
3. Because readers may not be familiar with the LE 8 score, I suggest including the exact scoring
system.
I look forward to reading the final version of this interesting paper.
Please review this paper.
user
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 0 Date: 24 Jun 2024
Reviewer's report:
I found Zhang et al’s paper on the Associations between Life’s Essential 8 and the Prognosis of
Alcoholic Liver disease to be very interesting and well written. I found the topic relevant and
the statistical analysis to be robust. I am eager to see how if improving LE8 could improve CV
mortality in this patient population.
I have only a few comments:
1. I recommend the authors update their use of the term “alcoholic” to “alcohol related” or
“alcohol associated.”
2. According to the supplementary information, the ALD patients were included if liver enzymes
were elevated in the setting of significant alcohol intake. Please specify whether other liver
diseases were  excluded in these patients? Also, cirrhosis can occur in the setting of normal liver
enzymes. Were patients with chronic liver disease but normal liver enzymes also included in
the analysis?
3. Because readers may not be familiar with the LE 8 score, I suggest including the exact scoring
system.
I look forward to reading the final version of this interesting paper.
assistant