Title: Endoscopic and histopathological hints on infections in patients of common variable
immunodeficiency disorder with gastrointestinal symptoms
Version: 3 Date: 16 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: I read with interest the manuscript by Chen et al. The authors
performed a descriptive study on infections in patients with CVID with GI symptoms. I have
the following comments.
1. The introduction seems long and can be cut down. Be more precise to deliver the message.
2. Was there a particular protocol used for obtaining endoscopic samples from respective GI
site? Please clarify in methods.
3. Based on this study, can the authors propose an algorithm regarding what assessments and
workup needs to be undertaken if patient has GI symptoms and CVID? This will be helpful for
readers.
Title: Endoscopic and histopathological hints on infections in patients of common variable
immunodeficiency disorder with gastrointestinal symptoms
Version: 3 Date: 16 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: I read with interest the manuscript by Chen et al. The authors
performed a descriptive study on infections in patients with CVID with GI symptoms. I have
the following comments.
1. The introduction seems long and can be cut down. Be more precise to deliver the message.
2. Was there a particular protocol used for obtaining endoscopic samples from respective GI
site? Please clarify in methods.
3. Based on this study, can the authors propose an algorithm regarding what assessments and
workup needs to be undertaken if patient has GI symptoms and CVID? This will be helpful for
readers.
Please review this paper.
user
Title: Endoscopic and histopathological hints on infections in patients of common variable
immunodeficiency disorder with gastrointestinal symptoms
Version: 3 Date: 16 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: I read with interest the manuscript by Chen et al. The authors
performed a descriptive study on infections in patients with CVID with GI symptoms. I have
the following comments.
1. The introduction seems long and can be cut down. Be more precise to deliver the message.
2. Was there a particular protocol used for obtaining endoscopic samples from respective GI
site? Please clarify in methods.
3. Based on this study, can the authors propose an algorithm regarding what assessments and
workup needs to be undertaken if patient has GI symptoms and CVID? This will be helpful for
readers.
assistant