Reviewer's report
Title:Volume, distribution and acidity of gastric secretion on and off proton pump
inhibitor treatment: A randomized double-blind controlled study in patients with
gastro-esophageal reflux disease (GERD) and healthy subjects
Version:1Date:30 June 2015
Reviewer: Giovanni Sarnelli
Reviewer's report:
Major:
This is a well conducted study addressing the pathophysiological role and the
potential therapeuthic implications of acid pocket in GERD. Using a combined
pH-metry and MRI study before and after PPI the authors showed that the
distribution of gastric secretions in the stomach is abnormal in GERD patients
and resulted in prolonged exposure of the EGJ to unbuffered gastric secretions,
likely associated to postprandial GERD-symptoms.
Minor:
I understand that the simultaneous assessment of pH-metry and MRI is
technically difficult, but this represent a point of weakness. The authors should
further comment this point in the discussion and tone down their results.
Given the great progress of the MRI technique do the authors have any data
magnetic resonance spectroscopy ? If not this should reported as a potential
future application.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Reviewer's report
Title:Volume, distribution and acidity of gastric secretion on and off proton pump
inhibitor treatment: A randomized double-blind controlled study in patients with
gastro-esophageal reflux disease (GERD) and healthy subjects
Version:1Date:30 June 2015
Reviewer: Giovanni Sarnelli
Reviewer's report:
Major:
This is a well conducted study addressing the pathophysiological role and the
potential therapeuthic implications of acid pocket in GERD. Using a combined
pH-metry and MRI study before and after PPI the authors showed that the
distribution of gastric secretions in the stomach is abnormal in GERD patients
and resulted in prolonged exposure of the EGJ to unbuffered gastric secretions,
likely associated to postprandial GERD-symptoms.
Minor:
I understand that the simultaneous assessment of pH-metry and MRI is
technically difficult, but this represent a point of weakness. The authors should
further comment this point in the discussion and tone down their results.
Given the great progress of the MRI technique do the authors have any data
magnetic resonance spectroscopy ? If not this should reported as a potential
future application.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Please review this paper.
user
Reviewer's report
Title:Volume, distribution and acidity of gastric secretion on and off proton pump
inhibitor treatment: A randomized double-blind controlled study in patients with
gastro-esophageal reflux disease (GERD) and healthy subjects
Version:1Date:30 June 2015
Reviewer: Giovanni Sarnelli
Reviewer's report:
Major:
This is a well conducted study addressing the pathophysiological role and the
potential therapeuthic implications of acid pocket in GERD. Using a combined
pH-metry and MRI study before and after PPI the authors showed that the
distribution of gastric secretions in the stomach is abnormal in GERD patients
and resulted in prolonged exposure of the EGJ to unbuffered gastric secretions,
likely associated to postprandial GERD-symptoms.
Minor:
I understand that the simultaneous assessment of pH-metry and MRI is
technically difficult, but this represent a point of weakness. The authors should
further comment this point in the discussion and tone down their results.
Given the great progress of the MRI technique do the authors have any data
magnetic resonance spectroscopy ? If not this should reported as a potential
future application.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
assistant