Title: Magnetic controlled capsule endoscope (MCCE) ‘s diagnostic performance for H. pylori
infection status based on the Kyoto classification of gastritis
Version: 1 Date: 13 Sep 2022
Reviewer's report:
Validation of Kyoto classification of gastritis on magnetic controlled capsule endoscope
A prospective study evaluating whether Kyoto classification of gastritis applies well on magnetic
controlled capsule endoscopy. However, several major issues should be addressed before further
assessment.
Major comments
1. The design of the study is too complex and redundant. This article consists of two parts, but
neither part clearly states the primary endpoint of this study. In the first part, it demonstrated
that major findings documented in Kyoto classification of gastritis could be well recognized on
MCCE. However, in the second part, the primary outcome became the diagnostic accuracy of
MCCE in diagnosis of H. pylori infection. The first and second parts of the manuscript are not
closely related.
2. In order to strengthen the connection between the first part and the second part of the
manuscript, the “Kyoto classification of gastritis” under MCE should be further defined based
on the results of the first part of this study.
3. In the second part of this manuscript, we did not see the role of “Kyoto classification of
gastritis” in the assessment of Helicobacter pylori infection by magnetic controlled capsule
endoscopy (MCCE). The title of the second part of this manuscript is more suitable for
“Accuracy of MCCE in Assessing Helicobacter pylori Infection”.
4. In conclusion, since previous studies have demonstrated that the diagnostic performance of
MCE is comparable with EGD. It is recommended to delete the first part of the article. The
definition of “MCCE’s Kyoto classification of gastritis” could be added in the manuscript as
figures. And the title of this article could be changed to “Accuracy of MCCE in Assessing
Helicobacter pylori Infection”.
minor issues:
1. Methods- the section of “sample size calculation” should be described in “Statistical Analysis”
section.
2. The discussion section is too long and should be shortened to 3-5 paragraphs.
Title: Magnetic controlled capsule endoscope (MCCE) ‘s diagnostic performance for H. pylori
infection status based on the Kyoto classification of gastritis
Version: 1 Date: 13 Sep 2022
Reviewer's report:
Validation of Kyoto classification of gastritis on magnetic controlled capsule endoscope
A prospective study evaluating whether Kyoto classification of gastritis applies well on magnetic
controlled capsule endoscopy. However, several major issues should be addressed before further
assessment.
Major comments
1. The design of the study is too complex and redundant. This article consists of two parts, but
neither part clearly states the primary endpoint of this study. In the first part, it demonstrated
that major findings documented in Kyoto classification of gastritis could be well recognized on
MCCE. However, in the second part, the primary outcome became the diagnostic accuracy of
MCCE in diagnosis of H. pylori infection. The first and second parts of the manuscript are not
closely related.
2. In order to strengthen the connection between the first part and the second part of the
manuscript, the “Kyoto classification of gastritis” under MCE should be further defined based
on the results of the first part of this study.
3. In the second part of this manuscript, we did not see the role of “Kyoto classification of
gastritis” in the assessment of Helicobacter pylori infection by magnetic controlled capsule
endoscopy (MCCE). The title of the second part of this manuscript is more suitable for
“Accuracy of MCCE in Assessing Helicobacter pylori Infection”.
4. In conclusion, since previous studies have demonstrated that the diagnostic performance of
MCE is comparable with EGD. It is recommended to delete the first part of the article. The
definition of “MCCE’s Kyoto classification of gastritis” could be added in the manuscript as
figures. And the title of this article could be changed to “Accuracy of MCCE in Assessing
Helicobacter pylori Infection”.
minor issues:
1. Methods- the section of “sample size calculation” should be described in “Statistical Analysis”
section.
2. The discussion section is too long and should be shortened to 3-5 paragraphs.
Please review this paper.
user
Title: Magnetic controlled capsule endoscope (MCCE) ‘s diagnostic performance for H. pylori
infection status based on the Kyoto classification of gastritis
Version: 1 Date: 13 Sep 2022
Reviewer's report:
Validation of Kyoto classification of gastritis on magnetic controlled capsule endoscope
A prospective study evaluating whether Kyoto classification of gastritis applies well on magnetic
controlled capsule endoscopy. However, several major issues should be addressed before further
assessment.
Major comments
1. The design of the study is too complex and redundant. This article consists of two parts, but
neither part clearly states the primary endpoint of this study. In the first part, it demonstrated
that major findings documented in Kyoto classification of gastritis could be well recognized on
MCCE. However, in the second part, the primary outcome became the diagnostic accuracy of
MCCE in diagnosis of H. pylori infection. The first and second parts of the manuscript are not
closely related.
2. In order to strengthen the connection between the first part and the second part of the
manuscript, the “Kyoto classification of gastritis” under MCE should be further defined based
on the results of the first part of this study.
3. In the second part of this manuscript, we did not see the role of “Kyoto classification of
gastritis” in the assessment of Helicobacter pylori infection by magnetic controlled capsule
endoscopy (MCCE). The title of the second part of this manuscript is more suitable for
“Accuracy of MCCE in Assessing Helicobacter pylori Infection”.
4. In conclusion, since previous studies have demonstrated that the diagnostic performance of
MCE is comparable with EGD. It is recommended to delete the first part of the article. The
definition of “MCCE’s Kyoto classification of gastritis” could be added in the manuscript as
figures. And the title of this article could be changed to “Accuracy of MCCE in Assessing
Helicobacter pylori Infection”.
minor issues:
1. Methods- the section of “sample size calculation” should be described in “Statistical Analysis”
section.
2. The discussion section is too long and should be shortened to 3-5 paragraphs.
assistant