Title: A systematic review and meta-analysis#The therapeutic and preventive effect of
Lactobacillus reuteri DSM 17938 addition in children with diarrhea
Version: 2 Date: 19 Feb 2023
Reviewer's report:
Dear Editor
Thanks for the opportunity to review the manuscript titled, " A systematic review and meta-
analysis# The therapeutic and preventive effect of Lactobacillus reuteri DSM 17938 addition
in children with diarrhea’’. The authors present a meta-analysis of 9 studies with a total of 963
patients that met the eligibility criteria to evaluate the ability of Lactobacillus reuteri DSM 17938
to treat and prevent various types of diarrheal diseases in children. Based on their analysis the
authors concluded that " Addition of Lactobacillus reuteri in the treatment plan has a significant
effect on reducing the number of diarrhea and reducing the symptoms of diarrhea, but has no
obvious effect on the prevention of diarrhea’’. the overall conclusion reached by the authors is
reasonable.  the manuscript is well written, the methods are rigorous and the results are well
presented in tables, the claims appropriately were discussed in the context of previous literature.
Best wishes,
Title: A systematic review and meta-analysis#The therapeutic and preventive effect of
Lactobacillus reuteri DSM 17938 addition in children with diarrhea
Version: 2 Date: 19 Feb 2023
Reviewer's report:
Dear Editor
Thanks for the opportunity to review the manuscript titled, " A systematic review and meta-
analysis# The therapeutic and preventive effect of Lactobacillus reuteri DSM 17938 addition
in children with diarrhea’’. The authors present a meta-analysis of 9 studies with a total of 963
patients that met the eligibility criteria to evaluate the ability of Lactobacillus reuteri DSM 17938
to treat and prevent various types of diarrheal diseases in children. Based on their analysis the
authors concluded that " Addition of Lactobacillus reuteri in the treatment plan has a significant
effect on reducing the number of diarrhea and reducing the symptoms of diarrhea, but has no
obvious effect on the prevention of diarrhea’’. the overall conclusion reached by the authors is
reasonable.  the manuscript is well written, the methods are rigorous and the results are well
presented in tables, the claims appropriately were discussed in the context of previous literature.
Best wishes,
Please review this paper.
user
Title: A systematic review and meta-analysis#The therapeutic and preventive effect of
Lactobacillus reuteri DSM 17938 addition in children with diarrhea
Version: 2 Date: 19 Feb 2023
Reviewer's report:
Dear Editor
Thanks for the opportunity to review the manuscript titled, " A systematic review and meta-
analysis# The therapeutic and preventive effect of Lactobacillus reuteri DSM 17938 addition
in children with diarrhea’’. The authors present a meta-analysis of 9 studies with a total of 963
patients that met the eligibility criteria to evaluate the ability of Lactobacillus reuteri DSM 17938
to treat and prevent various types of diarrheal diseases in children. Based on their analysis the
authors concluded that " Addition of Lactobacillus reuteri in the treatment plan has a significant
effect on reducing the number of diarrhea and reducing the symptoms of diarrhea, but has no
obvious effect on the prevention of diarrhea’’. the overall conclusion reached by the authors is
reasonable.  the manuscript is well written, the methods are rigorous and the results are well
presented in tables, the claims appropriately were discussed in the context of previous literature.
Best wishes,
assistant