Title: Mechanistic investigation and the optimal dose based on baicalin in the treatment of
ulcerative colitis--A preclinical systematic review and meta-analysis
Version: 3 Date: 28 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
The authors should stess they had not studied UC which a human disease but animal models
of UC Abstract Authors should point out that they mainly searched animal studies Thus they
studies mainly animal models not UC Methods Was there any restriction in the language of
publications? Criteria for data biases should be provided Why highest dose has been selected
in the analysis and not most effective dose?  was there any possibility to group  doses utilized?
Why authors have selected 100 mg/kg dose? Statistics Does funnel plot analysis was performed?
Title: Mechanistic investigation and the optimal dose based on baicalin in the treatment of
ulcerative colitis--A preclinical systematic review and meta-analysis
Version: 3 Date: 28 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
The authors should stess they had not studied UC which a human disease but animal models
of UC Abstract Authors should point out that they mainly searched animal studies Thus they
studies mainly animal models not UC Methods Was there any restriction in the language of
publications? Criteria for data biases should be provided Why highest dose has been selected
in the analysis and not most effective dose?  was there any possibility to group  doses utilized?
Why authors have selected 100 mg/kg dose? Statistics Does funnel plot analysis was performed?
Please review this paper.
user
Title: Mechanistic investigation and the optimal dose based on baicalin in the treatment of
ulcerative colitis--A preclinical systematic review and meta-analysis
Version: 3 Date: 28 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
The authors should stess they had not studied UC which a human disease but animal models
of UC Abstract Authors should point out that they mainly searched animal studies Thus they
studies mainly animal models not UC Methods Was there any restriction in the language of
publications? Criteria for data biases should be provided Why highest dose has been selected
in the analysis and not most effective dose?  was there any possibility to group  doses utilized?
Why authors have selected 100 mg/kg dose? Statistics Does funnel plot analysis was performed?
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