Title: Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for
screening colorectal cancer in the Otog Front Banner
Version: 0 Date: 26 Nov 2024
Reviewer's report:
I found the manuscript on the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation
test for screening colorectal cancer in the Otokqianqi area. This article could be considered for
publication pending resolution of the issues outlined below.
1. There is a discrepancy between the figures presented in Table 1 and 3.1. Furthermore, the
numerical values presented in Table 1 for each age group do not correspond with the total figure.
2. The P-value indicated in Table 2 is erroneous.
3. The title of Table 3 is "Multivariate Analysis of FIT-Positive Patients," which may be a
typographical error in the DNA test.
4. The interpretation of the gender difference in 3.3 is erroneous.
5. The description method and statistical interpretation presented in Table 4 are erroneous.
6. Reference 28 states that the sensitivity is 85%, however this result does not include
precancerous lesions, therefore it is incorrect.
7. A review of the discussion content reveals a redundancy.
8. Ben Lil, et al. did not utilize the SDC2/ADHFE1/PPP2R5C gene methylation test for
screening, therefore the description is inaccurate.
Title: Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for
screening colorectal cancer in the Otog Front Banner
Version: 0 Date: 26 Nov 2024
Reviewer's report:
I found the manuscript on the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation
test for screening colorectal cancer in the Otokqianqi area. This article could be considered for
publication pending resolution of the issues outlined below.
1. There is a discrepancy between the figures presented in Table 1 and 3.1. Furthermore, the
numerical values presented in Table 1 for each age group do not correspond with the total figure.
2. The P-value indicated in Table 2 is erroneous.
3. The title of Table 3 is "Multivariate Analysis of FIT-Positive Patients," which may be a
typographical error in the DNA test.
4. The interpretation of the gender difference in 3.3 is erroneous.
5. The description method and statistical interpretation presented in Table 4 are erroneous.
6. Reference 28 states that the sensitivity is 85%, however this result does not include
precancerous lesions, therefore it is incorrect.
7. A review of the discussion content reveals a redundancy.
8. Ben Lil, et al. did not utilize the SDC2/ADHFE1/PPP2R5C gene methylation test for
screening, therefore the description is inaccurate.
Please review this paper.
user
Title: Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for
screening colorectal cancer in the Otog Front Banner
Version: 0 Date: 26 Nov 2024
Reviewer's report:
I found the manuscript on the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation
test for screening colorectal cancer in the Otokqianqi area. This article could be considered for
publication pending resolution of the issues outlined below.
1. There is a discrepancy between the figures presented in Table 1 and 3.1. Furthermore, the
numerical values presented in Table 1 for each age group do not correspond with the total figure.
2. The P-value indicated in Table 2 is erroneous.
3. The title of Table 3 is "Multivariate Analysis of FIT-Positive Patients," which may be a
typographical error in the DNA test.
4. The interpretation of the gender difference in 3.3 is erroneous.
5. The description method and statistical interpretation presented in Table 4 are erroneous.
6. Reference 28 states that the sensitivity is 85%, however this result does not include
precancerous lesions, therefore it is incorrect.
7. A review of the discussion content reveals a redundancy.
8. Ben Lil, et al. did not utilize the SDC2/ADHFE1/PPP2R5C gene methylation test for
screening, therefore the description is inaccurate.
assistant