Title: The Diagnostic Value of Dynamic Contrast-Enhanced Ultrasound for Evaluation of
Tissue Oxygen Status in Rat Hepatoma Model
Version: 1 Date: 12 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Apart from p-values numerical values should be also provided AS should be explained
Methods Authors should explained why they selected the particular size of tumors if not in
the methods section at least in introduction They also provide biobliographic reference that use
L11-3U  probe is adequate to measure circulation in rat liver, as well as polarography  Was
there an quantitative auto-tracking contrast quantification software used? Results Characteristics
of the two models selected that led authors to prefer them should be reported Was there any
difference in tumor oxygenation between tumor periphery and center?
Title: The Diagnostic Value of Dynamic Contrast-Enhanced Ultrasound for Evaluation of
Tissue Oxygen Status in Rat Hepatoma Model
Version: 1 Date: 12 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Apart from p-values numerical values should be also provided AS should be explained
Methods Authors should explained why they selected the particular size of tumors if not in
the methods section at least in introduction They also provide biobliographic reference that use
L11-3U  probe is adequate to measure circulation in rat liver, as well as polarography  Was
there an quantitative auto-tracking contrast quantification software used? Results Characteristics
of the two models selected that led authors to prefer them should be reported Was there any
difference in tumor oxygenation between tumor periphery and center?
Please review this paper.
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Title: The Diagnostic Value of Dynamic Contrast-Enhanced Ultrasound for Evaluation of
Tissue Oxygen Status in Rat Hepatoma Model
Version: 1 Date: 12 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Apart from p-values numerical values should be also provided AS should be explained
Methods Authors should explained why they selected the particular size of tumors if not in
the methods section at least in introduction They also provide biobliographic reference that use
L11-3U  probe is adequate to measure circulation in rat liver, as well as polarography  Was
there an quantitative auto-tracking contrast quantification software used? Results Characteristics
of the two models selected that led authors to prefer them should be reported Was there any
difference in tumor oxygenation between tumor periphery and center?
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