Title: Timing of endoscopy in patients with cirrhosis and acute variceal bleeding: A single-
center retrospective study
Version: 2 Date: 25 Oct 2022
Reviewer's report:
In this manuscript Peng and collegues perform a retrospective analysis aiming to determine the
best time point in performing upper endoscopy for patients with variceal bleeding.
Although the manuscript is in general well written, i highly doubt the general value of performing
another retrospective analysis given that we cannot answer the question under investigation with
this given study design.
In fact, numerous retrospective anlyses of the same kind already exist in the literature and two
larger recent meta-analysis of those studies ( Eur J Gastroenterol Hepatol 2021  and Scientific
Report 2020) analyze the same question with higher patient numbers. They all conclude with a
high remaining degree of uncertainty without being able to show superiority of early endoscopy.
I  thus strongly believe, that we do not need another after another retrospective series, but rather
a well powered prospective multi-center trial in order to  proceed in the field.
Title: Timing of endoscopy in patients with cirrhosis and acute variceal bleeding: A single-
center retrospective study
Version: 2 Date: 25 Oct 2022
Reviewer's report:
In this manuscript Peng and collegues perform a retrospective analysis aiming to determine the
best time point in performing upper endoscopy for patients with variceal bleeding.
Although the manuscript is in general well written, i highly doubt the general value of performing
another retrospective analysis given that we cannot answer the question under investigation with
this given study design.
In fact, numerous retrospective anlyses of the same kind already exist in the literature and two
larger recent meta-analysis of those studies ( Eur J Gastroenterol Hepatol 2021  and Scientific
Report 2020) analyze the same question with higher patient numbers. They all conclude with a
high remaining degree of uncertainty without being able to show superiority of early endoscopy.
I  thus strongly believe, that we do not need another after another retrospective series, but rather
a well powered prospective multi-center trial in order to  proceed in the field.
Please review this paper.
user
Title: Timing of endoscopy in patients with cirrhosis and acute variceal bleeding: A single-
center retrospective study
Version: 2 Date: 25 Oct 2022
Reviewer's report:
In this manuscript Peng and collegues perform a retrospective analysis aiming to determine the
best time point in performing upper endoscopy for patients with variceal bleeding.
Although the manuscript is in general well written, i highly doubt the general value of performing
another retrospective analysis given that we cannot answer the question under investigation with
this given study design.
In fact, numerous retrospective anlyses of the same kind already exist in the literature and two
larger recent meta-analysis of those studies ( Eur J Gastroenterol Hepatol 2021  and Scientific
Report 2020) analyze the same question with higher patient numbers. They all conclude with a
high remaining degree of uncertainty without being able to show superiority of early endoscopy.
I  thus strongly believe, that we do not need another after another retrospective series, but rather
a well powered prospective multi-center trial in order to  proceed in the field.
assistant