Reviewer's report
Title:Four novel mutations in the lactase gene (LCT) underlying congenital
lactase deficiency (CLD)
Version: 2Date:30 September 2008
Reviewer: Dallas M Swallow
Reviewer's report:
Minor essential revisions
1 Most of the errors in the English of the original text have been corrected,
though new ones have been introduced in the altered text (see below).
Abstract. ‘Found from one/another ’ should read ‘found in one/another’
Living on Continental Europe should read ‘in Continental Europe’—but would
‘outside Finland’ be more precise?
All four novel mutations were predicted—(page 14)—should read ‘All four novel
mutations were examined by—
Line 4 of that paragraph should read ‘of occurring’—not ‘to occur’
Later in that paragraph –were considered to be pathogenic
Page 6 ‘based on the disappeared symptoms’—should read ‘based on the
disappearance of symptoms’
2 Some sentences are still unclear and I suggest wordings below—if this is what
is meant;
• Since the original reports by Holzel et al (1,9), there has been a lack of
published data about CLD countries other than Finland.
• The Blosum62 score for substitution from serine to proline etc –showed that
there is a low probability of either substitution occurring in a functional protein.
3 I am still not happy with the following sentence which is potentially very
confusing to the reader
‘It is noteworthy, that in these two conditions the values of lactase activity are
partially overlapping in spite of their having different underlying molecular
mechanism.[2, 5-8, 10] Therefore, further studies are needed to explain the
phenotype-genotype-correlation in human lactase deficiencies.-‘
I suggest that you should say:
‘It is noteworthy that the values of lactase activity are partially overlapping with
those found in adults with hypolactasia, but the major difference is that as
children these people had high lactase activity like lactase persistent people
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Four novel mutations in the lactase gene (LCT) underlying congenital
lactase deficiency (CLD)
Version: 2Date:30 September 2008
Reviewer: Dallas M Swallow
Reviewer's report:
Minor essential revisions
1 Most of the errors in the English of the original text have been corrected,
though new ones have been introduced in the altered text (see below).
Abstract. ‘Found from one/another ’ should read ‘found in one/another’
Living on Continental Europe should read ‘in Continental Europe’—but would
‘outside Finland’ be more precise?
All four novel mutations were predicted—(page 14)—should read ‘All four novel
mutations were examined by—
Line 4 of that paragraph should read ‘of occurring’—not ‘to occur’
Later in that paragraph –were considered to be pathogenic
Page 6 ‘based on the disappeared symptoms’—should read ‘based on the
disappearance of symptoms’
2 Some sentences are still unclear and I suggest wordings below—if this is what
is meant;
• Since the original reports by Holzel et al (1,9), there has been a lack of
published data about CLD countries other than Finland.
• The Blosum62 score for substitution from serine to proline etc –showed that
there is a low probability of either substitution occurring in a functional protein.
3 I am still not happy with the following sentence which is potentially very
confusing to the reader
‘It is noteworthy, that in these two conditions the values of lactase activity are
partially overlapping in spite of their having different underlying molecular
mechanism.[2, 5-8, 10] Therefore, further studies are needed to explain the
phenotype-genotype-correlation in human lactase deficiencies.-‘
I suggest that you should say:
‘It is noteworthy that the values of lactase activity are partially overlapping with
those found in adults with hypolactasia, but the major difference is that as
children these people had high lactase activity like lactase persistent people
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Four novel mutations in the lactase gene (LCT) underlying congenital
lactase deficiency (CLD)
Version: 2Date:30 September 2008
Reviewer: Dallas M Swallow
Reviewer's report:
Minor essential revisions
1 Most of the errors in the English of the original text have been corrected,
though new ones have been introduced in the altered text (see below).
Abstract. ‘Found from one/another ’ should read ‘found in one/another’
Living on Continental Europe should read ‘in Continental Europe’—but would
‘outside Finland’ be more precise?
All four novel mutations were predicted—(page 14)—should read ‘All four novel
mutations were examined by—
Line 4 of that paragraph should read ‘of occurring’—not ‘to occur’
Later in that paragraph –were considered to be pathogenic
Page 6 ‘based on the disappeared symptoms’—should read ‘based on the
disappearance of symptoms’
2 Some sentences are still unclear and I suggest wordings below—if this is what
is meant;
• Since the original reports by Holzel et al (1,9), there has been a lack of
published data about CLD countries other than Finland.
• The Blosum62 score for substitution from serine to proline etc –showed that
there is a low probability of either substitution occurring in a functional protein.
3 I am still not happy with the following sentence which is potentially very
confusing to the reader
‘It is noteworthy, that in these two conditions the values of lactase activity are
partially overlapping in spite of their having different underlying molecular
mechanism.[2, 5-8, 10] Therefore, further studies are needed to explain the
phenotype-genotype-correlation in human lactase deficiencies.-‘
I suggest that you should say:
‘It is noteworthy that the values of lactase activity are partially overlapping with
those found in adults with hypolactasia, but the major difference is that as
children these people had high lactase activity like lactase persistent people
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant