Title: Risk factors and predictive nomograms for early death of patients with advanced
hepatocellular carcinoma: a large retrospective study based on the SEER database
Version: 5 Date: 23 May 2022
Reviewer's report:
The manuscript has had considerable improvements, congratulations to the authors.
I suggest small changes/improvements:
1. The authors report the use of multivariate analysis but do not detail the methods used for the
selection of variables. Backward selection? forward selection? Clinical criteria?. Please detail
the methodology.
2. In the results, in addition to reporting OR and p value, please also report the 95% CI. The reader
does not have the ability to analyze the statistical power of the analysis with these 2 indices alone
and, in fact, most people give greater importance to the IC itself than to the reported indices.
Title: Risk factors and predictive nomograms for early death of patients with advanced
hepatocellular carcinoma: a large retrospective study based on the SEER database
Version: 5 Date: 23 May 2022
Reviewer's report:
The manuscript has had considerable improvements, congratulations to the authors.
I suggest small changes/improvements:
1. The authors report the use of multivariate analysis but do not detail the methods used for the
selection of variables. Backward selection? forward selection? Clinical criteria?. Please detail
the methodology.
2. In the results, in addition to reporting OR and p value, please also report the 95% CI. The reader
does not have the ability to analyze the statistical power of the analysis with these 2 indices alone
and, in fact, most people give greater importance to the IC itself than to the reported indices.
Please review this paper.
user
Title: Risk factors and predictive nomograms for early death of patients with advanced
hepatocellular carcinoma: a large retrospective study based on the SEER database
Version: 5 Date: 23 May 2022
Reviewer's report:
The manuscript has had considerable improvements, congratulations to the authors.
I suggest small changes/improvements:
1. The authors report the use of multivariate analysis but do not detail the methods used for the
selection of variables. Backward selection? forward selection? Clinical criteria?. Please detail
the methodology.
2. In the results, in addition to reporting OR and p value, please also report the 95% CI. The reader
does not have the ability to analyze the statistical power of the analysis with these 2 indices alone
and, in fact, most people give greater importance to the IC itself than to the reported indices.
assistant