Title: Correlation between serum liver fibrosis markers and early gastroesophageal varices
among patients with compensated liver cirrhosis: a cross-sectional analysis
Version: 1 Date: 23 Aug 2022
Reviewer's report:
I read the study with great interest.
English writing needs review.
Although a modern technology has been chosen to evaluate early portal hypertension, diagnosis
os liver cirrhosis was neither based on liver biopsy, wich represents a limitation in a study of
liver fibrosis. Ultrasound, tomography and resonance cannot detect liver cirrhosis with the same
specificity and sensitivity of liver biopsy.
What happened with patients with esophageal varices in upper digestive endoscopy? Were they
excluded from the study? How many were they?
Why did you choose not to use simple blood markers of liver fibrosis such as APRI and FIB-4
instead of platelets and aminotransferases?
It is not possible to claim that laminin can be used as a routine reference
index for monitoring gastroesophageal varies in patients with compensated liver cirrhosis. It
may be used, but a prospective study with this aim has to be done to evaluate its diagnostic
performance. Can you test PPV and PNV of laminin in predicting early gastroesophageal
varices?
Title: Correlation between serum liver fibrosis markers and early gastroesophageal varices
among patients with compensated liver cirrhosis: a cross-sectional analysis
Version: 1 Date: 23 Aug 2022
Reviewer's report:
I read the study with great interest.
English writing needs review.
Although a modern technology has been chosen to evaluate early portal hypertension, diagnosis
os liver cirrhosis was neither based on liver biopsy, wich represents a limitation in a study of
liver fibrosis. Ultrasound, tomography and resonance cannot detect liver cirrhosis with the same
specificity and sensitivity of liver biopsy.
What happened with patients with esophageal varices in upper digestive endoscopy? Were they
excluded from the study? How many were they?
Why did you choose not to use simple blood markers of liver fibrosis such as APRI and FIB-4
instead of platelets and aminotransferases?
It is not possible to claim that laminin can be used as a routine reference
index for monitoring gastroesophageal varies in patients with compensated liver cirrhosis. It
may be used, but a prospective study with this aim has to be done to evaluate its diagnostic
performance. Can you test PPV and PNV of laminin in predicting early gastroesophageal
varices?
Please review this paper.
user
Title: Correlation between serum liver fibrosis markers and early gastroesophageal varices
among patients with compensated liver cirrhosis: a cross-sectional analysis
Version: 1 Date: 23 Aug 2022
Reviewer's report:
I read the study with great interest.
English writing needs review.
Although a modern technology has been chosen to evaluate early portal hypertension, diagnosis
os liver cirrhosis was neither based on liver biopsy, wich represents a limitation in a study of
liver fibrosis. Ultrasound, tomography and resonance cannot detect liver cirrhosis with the same
specificity and sensitivity of liver biopsy.
What happened with patients with esophageal varices in upper digestive endoscopy? Were they
excluded from the study? How many were they?
Why did you choose not to use simple blood markers of liver fibrosis such as APRI and FIB-4
instead of platelets and aminotransferases?
It is not possible to claim that laminin can be used as a routine reference
index for monitoring gastroesophageal varies in patients with compensated liver cirrhosis. It
may be used, but a prospective study with this aim has to be done to evaluate its diagnostic
performance. Can you test PPV and PNV of laminin in predicting early gastroesophageal
varices?
assistant