Reviewer's report
Title:Factors associated with growth disturbance at celiac disease diagnosis in
children: a retrospective cohort study
Version:1Date:30 July 2015
Reviewer: Cristina Meazza
Reviewer's report:
In this study Nurminen et al. investigated the association of impaired growth with
celiac disease (CD) in children. They showed that growth failure in CD children is
associated with young age and severe presentation at diagnosis. Furthermore,
they demonstrated that CD children who present with sole poor growth are
clinically different from children with other symptoms. The study is interesting for
paediatricians who usually face with short statured children and the design is
commendable.
Specific comments:
• There are many studies about the association of CD and growth hormone
deficiency which sometimes is the cause of short stature in these children.
Therefore, when a catch-up growth is not shown after at least one year of gluten
free diet, an endocrinological evaluation is mandatory. The authors should
discuss this issue in the discussion.
• In table 1, patients are grouped according the presence or absence of growth
failure at diagnosis. Growth failure patients are 182, but in only 45 data about
height are available. How were the authors able to classify patients with growth
failure without having height data?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Factors associated with growth disturbance at celiac disease diagnosis in
children: a retrospective cohort study
Version:1Date:30 July 2015
Reviewer: Cristina Meazza
Reviewer's report:
In this study Nurminen et al. investigated the association of impaired growth with
celiac disease (CD) in children. They showed that growth failure in CD children is
associated with young age and severe presentation at diagnosis. Furthermore,
they demonstrated that CD children who present with sole poor growth are
clinically different from children with other symptoms. The study is interesting for
paediatricians who usually face with short statured children and the design is
commendable.
Specific comments:
• There are many studies about the association of CD and growth hormone
deficiency which sometimes is the cause of short stature in these children.
Therefore, when a catch-up growth is not shown after at least one year of gluten
free diet, an endocrinological evaluation is mandatory. The authors should
discuss this issue in the discussion.
• In table 1, patients are grouped according the presence or absence of growth
failure at diagnosis. Growth failure patients are 182, but in only 45 data about
height are available. How were the authors able to classify patients with growth
failure without having height data?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Factors associated with growth disturbance at celiac disease diagnosis in
children: a retrospective cohort study
Version:1Date:30 July 2015
Reviewer: Cristina Meazza
Reviewer's report:
In this study Nurminen et al. investigated the association of impaired growth with
celiac disease (CD) in children. They showed that growth failure in CD children is
associated with young age and severe presentation at diagnosis. Furthermore,
they demonstrated that CD children who present with sole poor growth are
clinically different from children with other symptoms. The study is interesting for
paediatricians who usually face with short statured children and the design is
commendable.
Specific comments:
• There are many studies about the association of CD and growth hormone
deficiency which sometimes is the cause of short stature in these children.
Therefore, when a catch-up growth is not shown after at least one year of gluten
free diet, an endocrinological evaluation is mandatory. The authors should
discuss this issue in the discussion.
• In table 1, patients are grouped according the presence or absence of growth
failure at diagnosis. Growth failure patients are 182, but in only 45 data about
height are available. How were the authors able to classify patients with growth
failure without having height data?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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