Reviewer ’s report  
 
Title: Magnetic Resonance Enterography, Colonoscopy, and Fecal Calprotectin correlate in 
colonic Crohn ’s Disease  
 
Version: 1 Date: 01 Oct 2019  
 
Reviewer: Antonino Caruso  
 
Reviewer's report:  
 
The Authors performed a study to assess the correlation between FCP, MRE and colonoscopy in 
CD patients.  
 
156 patients with colonic CD were included in the study.  
 
Different studies, in past years, evaluated the correlation between radiological (with con strat 
medium and DWI), biochemical and endoscopic parameters in ileo -colonic CD(see Caruso A. et 
al., IBD 2014; Rimola et al 2009).  
 
 
I suggest these revisions:  
 
- specify (in a table or in materials and methods section) the type of pharmacological therapy o f 
patients  
 
- add a control group  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the aut hors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an ad ditional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscri pt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either no w or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
No 
 
I agree to the open peer review policy of the journal. I understan d that my  name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
Reviewer ’s report  
 
Title: Magnetic Resonance Enterography, Colonoscopy, and Fecal Calprotectin correlate in 
colonic Crohn ’s Disease  
 
Version: 1 Date: 01 Oct 2019  
 
Reviewer: Antonino Caruso  
 
Reviewer's report:  
 
The Authors performed a study to assess the correlation between FCP, MRE and colonoscopy in 
CD patients.  
 
156 patients with colonic CD were included in the study.  
 
Different studies, in past years, evaluated the correlation between radiological (with con strat 
medium and DWI), biochemical and endoscopic parameters in ileo -colonic CD(see Caruso A. et 
al., IBD 2014; Rimola et al 2009).  
 
 
I suggest these revisions:  
 
- specify (in a table or in materials and methods section) the type of pharmacological therapy o f 
patients  
 
- add a control group  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the aut hors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an ad ditional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscri pt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either no w or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
No 
 
I agree to the open peer review policy of the journal. I understan d that my  name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
Please review this paper.
user
Reviewer ’s report  
 
Title: Magnetic Resonance Enterography, Colonoscopy, and Fecal Calprotectin correlate in 
colonic Crohn ’s Disease  
 
Version: 1 Date: 01 Oct 2019  
 
Reviewer: Antonino Caruso  
 
Reviewer's report:  
 
The Authors performed a study to assess the correlation between FCP, MRE and colonoscopy in 
CD patients.  
 
156 patients with colonic CD were included in the study.  
 
Different studies, in past years, evaluated the correlation between radiological (with con strat 
medium and DWI), biochemical and endoscopic parameters in ileo -colonic CD(see Caruso A. et 
al., IBD 2014; Rimola et al 2009).  
 
 
I suggest these revisions:  
 
- specify (in a table or in materials and methods section) the type of pharmacological therapy o f 
patients  
 
- add a control group  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the aut hors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an ad ditional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscri pt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either no w or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
No 
 
I agree to the open peer review policy of the journal. I understan d that my  name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
assistant