Title: Comprehensive Analysis of the Biological Function and Immune Infiltration of SLC38A2
in Gastric Cancer
Version: 1 Date: 31 Dec 2022
Reviewer:  Tianyi Fang
Reviewer's report:
This manuscript reported the possibility of SLC38A2 as a biomarker of gastric cancer. It was
verified by bioinformatics, vivo and vitro experiments. This research is satisfactory and the
results are reliable. Publishing can be considered after minor revision.
1. I think immunohistochemistry is not satisfactory. At least the expression of SLC38A2
in pathological sections of gastric cancer with different degrees of differentiation should be
included. In addition, I think the hematoxylin staining  is not enough, resulting in low contrast.
2.The discussion part of the manuscript is too simple. The complex interaction between
SLC38A2 and immune cells should be a highlight of this study and should be discussed in depth.
3.Why is the subcutaneous model of animal experiment not verified by immunohistochemistry?
At least SLC38A2 expression should be detected.
Title: Comprehensive Analysis of the Biological Function and Immune Infiltration of SLC38A2
in Gastric Cancer
Version: 1 Date: 31 Dec 2022
Reviewer:  Tianyi Fang
Reviewer's report:
This manuscript reported the possibility of SLC38A2 as a biomarker of gastric cancer. It was
verified by bioinformatics, vivo and vitro experiments. This research is satisfactory and the
results are reliable. Publishing can be considered after minor revision.
1. I think immunohistochemistry is not satisfactory. At least the expression of SLC38A2
in pathological sections of gastric cancer with different degrees of differentiation should be
included. In addition, I think the hematoxylin staining  is not enough, resulting in low contrast.
2.The discussion part of the manuscript is too simple. The complex interaction between
SLC38A2 and immune cells should be a highlight of this study and should be discussed in depth.
3.Why is the subcutaneous model of animal experiment not verified by immunohistochemistry?
At least SLC38A2 expression should be detected.
Please review this paper.
user
Title: Comprehensive Analysis of the Biological Function and Immune Infiltration of SLC38A2
in Gastric Cancer
Version: 1 Date: 31 Dec 2022
Reviewer:  Tianyi Fang
Reviewer's report:
This manuscript reported the possibility of SLC38A2 as a biomarker of gastric cancer. It was
verified by bioinformatics, vivo and vitro experiments. This research is satisfactory and the
results are reliable. Publishing can be considered after minor revision.
1. I think immunohistochemistry is not satisfactory. At least the expression of SLC38A2
in pathological sections of gastric cancer with different degrees of differentiation should be
included. In addition, I think the hematoxylin staining  is not enough, resulting in low contrast.
2.The discussion part of the manuscript is too simple. The complex interaction between
SLC38A2 and immune cells should be a highlight of this study and should be discussed in depth.
3.Why is the subcutaneous model of animal experiment not verified by immunohistochemistry?
At least SLC38A2 expression should be detected.
assistant