Reviewer's report
Title:Ringer's Lactate improves liver recovery in a murine model of
acetaminophen toxicity
Version: 1Date:9 March 2011
Reviewer: Jim P. Luyendyk
Reviewer's report:
The manuscript describes the effect of Ringer's lactate administration on
acetaminophen-induced liver injury in mice.
Major comment:
1) Although the results are intriguing, it is challenging to interpret the effect of
RLS on APAP-induced liver injury in the absence of inclusion of an additional
time point (i.e., 48 hours). The results indicate that RLS does not impact
APAP-induced necrosis at 24 hours, but offers protection at 72 hours, the latter
being a time point at which injury is almost completely resolved. Additional
studies are warranted.
2) Inclusion of additional measures of regeneration (i.e, PCNA) would strengthen
the manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Ringer's Lactate improves liver recovery in a murine model of
acetaminophen toxicity
Version: 1Date:9 March 2011
Reviewer: Jim P. Luyendyk
Reviewer's report:
The manuscript describes the effect of Ringer's lactate administration on
acetaminophen-induced liver injury in mice.
Major comment:
1) Although the results are intriguing, it is challenging to interpret the effect of
RLS on APAP-induced liver injury in the absence of inclusion of an additional
time point (i.e., 48 hours). The results indicate that RLS does not impact
APAP-induced necrosis at 24 hours, but offers protection at 72 hours, the latter
being a time point at which injury is almost completely resolved. Additional
studies are warranted.
2) Inclusion of additional measures of regeneration (i.e, PCNA) would strengthen
the manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Ringer's Lactate improves liver recovery in a murine model of
acetaminophen toxicity
Version: 1Date:9 March 2011
Reviewer: Jim P. Luyendyk
Reviewer's report:
The manuscript describes the effect of Ringer's lactate administration on
acetaminophen-induced liver injury in mice.
Major comment:
1) Although the results are intriguing, it is challenging to interpret the effect of
RLS on APAP-induced liver injury in the absence of inclusion of an additional
time point (i.e., 48 hours). The results indicate that RLS does not impact
APAP-induced necrosis at 24 hours, but offers protection at 72 hours, the latter
being a time point at which injury is almost completely resolved. Additional
studies are warranted.
2) Inclusion of additional measures of regeneration (i.e, PCNA) would strengthen
the manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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