Title: An Age-group Analysis on the Efficacy of Chemotherapy in Older Adult Patients with
Metastatic Biliary Tract Cancer: A Japanese Cancer Registry Cohort Study
Version: 2 Date: 12 May 2023
Reviewer:  Changqing Xie
Reviewer's report:
The authors Hirao T et al. presented a result from the analysis of efficacy of chemotherapy in
older adult patients with BTC based on patient's age. They used Japanese dataset with over 2600
patients included in the study. They found out older adult patients with metastatic BTC benefit
from chemotherapy especially patients whose age are less than 85 year old. This is an interesting
study and provides evidence to support chemotherapy in elderly patients with metastatic BTC.
This is also a well-designed and well written manuscript and will provide important information
in clinical practice.
Several information may need be addressed.
1) It seems like all patients were treated with chemotherapy in first line setting. Please include
some comments about the role of chemotherapy in second line setting in these population though
we have to acknowledge there is limited options even in general for metastatic BTC.
2) Please add the newly published KEYNOTE-966 data in the discussion.
Title: An Age-group Analysis on the Efficacy of Chemotherapy in Older Adult Patients with
Metastatic Biliary Tract Cancer: A Japanese Cancer Registry Cohort Study
Version: 2 Date: 12 May 2023
Reviewer:  Changqing Xie
Reviewer's report:
The authors Hirao T et al. presented a result from the analysis of efficacy of chemotherapy in
older adult patients with BTC based on patient's age. They used Japanese dataset with over 2600
patients included in the study. They found out older adult patients with metastatic BTC benefit
from chemotherapy especially patients whose age are less than 85 year old. This is an interesting
study and provides evidence to support chemotherapy in elderly patients with metastatic BTC.
This is also a well-designed and well written manuscript and will provide important information
in clinical practice.
Several information may need be addressed.
1) It seems like all patients were treated with chemotherapy in first line setting. Please include
some comments about the role of chemotherapy in second line setting in these population though
we have to acknowledge there is limited options even in general for metastatic BTC.
2) Please add the newly published KEYNOTE-966 data in the discussion.
Please review this paper.
user
Title: An Age-group Analysis on the Efficacy of Chemotherapy in Older Adult Patients with
Metastatic Biliary Tract Cancer: A Japanese Cancer Registry Cohort Study
Version: 2 Date: 12 May 2023
Reviewer:  Changqing Xie
Reviewer's report:
The authors Hirao T et al. presented a result from the analysis of efficacy of chemotherapy in
older adult patients with BTC based on patient's age. They used Japanese dataset with over 2600
patients included in the study. They found out older adult patients with metastatic BTC benefit
from chemotherapy especially patients whose age are less than 85 year old. This is an interesting
study and provides evidence to support chemotherapy in elderly patients with metastatic BTC.
This is also a well-designed and well written manuscript and will provide important information
in clinical practice.
Several information may need be addressed.
1) It seems like all patients were treated with chemotherapy in first line setting. Please include
some comments about the role of chemotherapy in second line setting in these population though
we have to acknowledge there is limited options even in general for metastatic BTC.
2) Please add the newly published KEYNOTE-966 data in the discussion.
assistant