Title: Perianal Disease Onset Age is Associated with Distinct Disease Features and Need for
Intestinal Resection in Perianal Crohn’s Disease: A Ten-year Hospital-based Observational
Study in China
Version: 2 Date: 10 May 2021
Reviewer's report:
Very honored author
Thank you very much for this interesting work.
The following questions arise:
- How was the delay defined in the diagnosis of PCD? Perianal symptoms do not mean that a
perianal fistula was already present at that time. Please specify exactly which starting point with
which symptoms was taken for this delay and how it could be defined retrospectively.
- What abdominal surgeries were performed? Are these comparable in both groups regarding
size and extensive of surgery (resections versus adhesiolysis etc.)?
- Clear definition of the primary endpoint and how or if this could be achieved.
- Is the need for abdominal surgery really age-associated and not also due to the other
comorbidities? A subgroup analysis with exclusion of smokers and others is certainly necessary.
- The group size of the two comparison groups is very different. Are these numbers really
comparable?
- Is there a correlation between the affected bowel segment and the severity of PCD?
Title: Perianal Disease Onset Age is Associated with Distinct Disease Features and Need for
Intestinal Resection in Perianal Crohn’s Disease: A Ten-year Hospital-based Observational
Study in China
Version: 2 Date: 10 May 2021
Reviewer's report:
Very honored author
Thank you very much for this interesting work.
The following questions arise:
- How was the delay defined in the diagnosis of PCD? Perianal symptoms do not mean that a
perianal fistula was already present at that time. Please specify exactly which starting point with
which symptoms was taken for this delay and how it could be defined retrospectively.
- What abdominal surgeries were performed? Are these comparable in both groups regarding
size and extensive of surgery (resections versus adhesiolysis etc.)?
- Clear definition of the primary endpoint and how or if this could be achieved.
- Is the need for abdominal surgery really age-associated and not also due to the other
comorbidities? A subgroup analysis with exclusion of smokers and others is certainly necessary.
- The group size of the two comparison groups is very different. Are these numbers really
comparable?
- Is there a correlation between the affected bowel segment and the severity of PCD?
Please review this paper.
user
Title: Perianal Disease Onset Age is Associated with Distinct Disease Features and Need for
Intestinal Resection in Perianal Crohn’s Disease: A Ten-year Hospital-based Observational
Study in China
Version: 2 Date: 10 May 2021
Reviewer's report:
Very honored author
Thank you very much for this interesting work.
The following questions arise:
- How was the delay defined in the diagnosis of PCD? Perianal symptoms do not mean that a
perianal fistula was already present at that time. Please specify exactly which starting point with
which symptoms was taken for this delay and how it could be defined retrospectively.
- What abdominal surgeries were performed? Are these comparable in both groups regarding
size and extensive of surgery (resections versus adhesiolysis etc.)?
- Clear definition of the primary endpoint and how or if this could be achieved.
- Is the need for abdominal surgery really age-associated and not also due to the other
comorbidities? A subgroup analysis with exclusion of smokers and others is certainly necessary.
- The group size of the two comparison groups is very different. Are these numbers really
comparable?
- Is there a correlation between the affected bowel segment and the severity of PCD?
assistant