Reviewer’ s report
Title: Endoscopic severe mucosal atrophy indicates the presence of gastric cancer after
Helicobacter pylori eradication -Analysis based on the Kyoto classification
Version: 1Date: 14 May 2020
Reviewer: Abdullah Yeniova
Reviewer's report:
The manuscript titled " Endoscopic severe mucosal atrophy indicates the presence of gastric
cancer after Helicobacter pylori eradication " has been reviewed.The authors aimed to find endoscopic predictor for early gastric cancer after HP eradicationAlthough it was known that HP is one of main risk factor for gastric cancer, patients can bediagnosed with gastric cancer after HP eradicationManuscript's main idea contribute to literature regarding HP and gastric cancer because it is aclinical debate that patients still can be diagnosed even if they had HP eradicationManuscript is suitable for publication after minor revision1)Authors stated that some facts underscore the importance of diagnosing HP infection andassessing the risk of gastric cancer ( page 8 line 20-26). This sentence is little bit confusingbecause before this sentence authors wirote that endoscopic curative resection can be performedfor early gastric cancer. What are the facts that underscore the diagnose of HP and assess the riskgastric cancer. Endoscopic submucosal dissection is a main treatment for early gastric cancer.Authors should explain in detail about this issue or delete this sentence.2) Why authors choose control group from medical routine check up patients. Maybe this selectionmay cause bias because patients who do not suffer from dyspepsia or any gastrointestinal
symptoms may not have gastritis on their esophagogastroduodenoscopy (EGD) and this cause a
diiferent between these groups in mean of total Kyoto risk score.3)The Kimura-Takemoto classification system is not routinely used in western countires andWestern gastroenterologist are not familiar with this classification system. It may be approriate thatauthors will include a table about this sytem4)What is Brinkman index? Authors should include this and explain in material and method
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interestsReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you must
decide whether to include your name at the start of the process and confirm this decision whenever
prompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
Reviewer’ s report
Title: Endoscopic severe mucosal atrophy indicates the presence of gastric cancer after
Helicobacter pylori eradication -Analysis based on the Kyoto classification
Version: 1Date: 14 May 2020
Reviewer: Abdullah Yeniova
Reviewer's report:
The manuscript titled " Endoscopic severe mucosal atrophy indicates the presence of gastric
cancer after Helicobacter pylori eradication " has been reviewed.The authors aimed to find endoscopic predictor for early gastric cancer after HP eradicationAlthough it was known that HP is one of main risk factor for gastric cancer, patients can bediagnosed with gastric cancer after HP eradicationManuscript's main idea contribute to literature regarding HP and gastric cancer because it is aclinical debate that patients still can be diagnosed even if they had HP eradicationManuscript is suitable for publication after minor revision1)Authors stated that some facts underscore the importance of diagnosing HP infection andassessing the risk of gastric cancer ( page 8 line 20-26). This sentence is little bit confusingbecause before this sentence authors wirote that endoscopic curative resection can be performedfor early gastric cancer. What are the facts that underscore the diagnose of HP and assess the riskgastric cancer. Endoscopic submucosal dissection is a main treatment for early gastric cancer.Authors should explain in detail about this issue or delete this sentence.2) Why authors choose control group from medical routine check up patients. Maybe this selectionmay cause bias because patients who do not suffer from dyspepsia or any gastrointestinal
symptoms may not have gastritis on their esophagogastroduodenoscopy (EGD) and this cause a
diiferent between these groups in mean of total Kyoto risk score.3)The Kimura-Takemoto classification system is not routinely used in western countires andWestern gastroenterologist are not familiar with this classification system. It may be approriate thatauthors will include a table about this sytem4)What is Brinkman index? Authors should include this and explain in material and method
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interestsReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you must
decide whether to include your name at the start of the process and confirm this decision whenever
prompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
Please review this paper.
user
Reviewer’ s report
Title: Endoscopic severe mucosal atrophy indicates the presence of gastric cancer after
Helicobacter pylori eradication -Analysis based on the Kyoto classification
Version: 1Date: 14 May 2020
Reviewer: Abdullah Yeniova
Reviewer's report:
The manuscript titled " Endoscopic severe mucosal atrophy indicates the presence of gastric
cancer after Helicobacter pylori eradication " has been reviewed.The authors aimed to find endoscopic predictor for early gastric cancer after HP eradicationAlthough it was known that HP is one of main risk factor for gastric cancer, patients can bediagnosed with gastric cancer after HP eradicationManuscript's main idea contribute to literature regarding HP and gastric cancer because it is aclinical debate that patients still can be diagnosed even if they had HP eradicationManuscript is suitable for publication after minor revision1)Authors stated that some facts underscore the importance of diagnosing HP infection andassessing the risk of gastric cancer ( page 8 line 20-26). This sentence is little bit confusingbecause before this sentence authors wirote that endoscopic curative resection can be performedfor early gastric cancer. What are the facts that underscore the diagnose of HP and assess the riskgastric cancer. Endoscopic submucosal dissection is a main treatment for early gastric cancer.Authors should explain in detail about this issue or delete this sentence.2) Why authors choose control group from medical routine check up patients. Maybe this selectionmay cause bias because patients who do not suffer from dyspepsia or any gastrointestinal
symptoms may not have gastritis on their esophagogastroduodenoscopy (EGD) and this cause a
diiferent between these groups in mean of total Kyoto risk score.3)The Kimura-Takemoto classification system is not routinely used in western countires andWestern gastroenterologist are not familiar with this classification system. It may be approriate thatauthors will include a table about this sytem4)What is Brinkman index? Authors should include this and explain in material and method
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interestsReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you must
decide whether to include your name at the start of the process and confirm this decision whenever
prompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
assistant