Title: Effect of disease duration on the association between C-reactive protein-albumin ratio
and endoscopic activity in ulcerative colitis
Version: 1 Date: 14 Nov 2021
Reviewer's report:
The authors investigated whether CAR could predict mucosal healing and endoscopic active
disease. Because measuring CRP and serum albumin is simple and relatively non-invasive, the
present manuscript might be useful for the clinicians to predict moderate to severe endoscopic
severity only using serum biomarkers. However, there are some concerns to solve.
CRP level is not usually elevated in patients with moderate severity in the clinical setting. If so,
CAR may be useful to distinct endoscopic severe cases from others. Maybe, it can be distinct
between MES of 3 and MES of 2 or MES 1-2 using CAR. This analysis is more useful than
the analysis of the present study in determining the indications and treatment strategies for
emergency endoscopy.
Also, the extent of disease may be associated with CRP and/or albumin in patients with moderate
to severe severity. However, the authors did not mention this content in the present manuscript.
The authors should present median (or mean) CAR in patients with each MES and should
compare the differences among MES 0, 1,2, or 3.
Why did the authors divide into 3 categories about CAR? How was the cut-off value determined?
Also, what is the reason for deciding 7 years a cut-off value?
Title: Effect of disease duration on the association between C-reactive protein-albumin ratio
and endoscopic activity in ulcerative colitis
Version: 1 Date: 14 Nov 2021
Reviewer's report:
The authors investigated whether CAR could predict mucosal healing and endoscopic active
disease. Because measuring CRP and serum albumin is simple and relatively non-invasive, the
present manuscript might be useful for the clinicians to predict moderate to severe endoscopic
severity only using serum biomarkers. However, there are some concerns to solve.
CRP level is not usually elevated in patients with moderate severity in the clinical setting. If so,
CAR may be useful to distinct endoscopic severe cases from others. Maybe, it can be distinct
between MES of 3 and MES of 2 or MES 1-2 using CAR. This analysis is more useful than
the analysis of the present study in determining the indications and treatment strategies for
emergency endoscopy.
Also, the extent of disease may be associated with CRP and/or albumin in patients with moderate
to severe severity. However, the authors did not mention this content in the present manuscript.
The authors should present median (or mean) CAR in patients with each MES and should
compare the differences among MES 0, 1,2, or 3.
Why did the authors divide into 3 categories about CAR? How was the cut-off value determined?
Also, what is the reason for deciding 7 years a cut-off value?
Please review this paper.
user
Title: Effect of disease duration on the association between C-reactive protein-albumin ratio
and endoscopic activity in ulcerative colitis
Version: 1 Date: 14 Nov 2021
Reviewer's report:
The authors investigated whether CAR could predict mucosal healing and endoscopic active
disease. Because measuring CRP and serum albumin is simple and relatively non-invasive, the
present manuscript might be useful for the clinicians to predict moderate to severe endoscopic
severity only using serum biomarkers. However, there are some concerns to solve.
CRP level is not usually elevated in patients with moderate severity in the clinical setting. If so,
CAR may be useful to distinct endoscopic severe cases from others. Maybe, it can be distinct
between MES of 3 and MES of 2 or MES 1-2 using CAR. This analysis is more useful than
the analysis of the present study in determining the indications and treatment strategies for
emergency endoscopy.
Also, the extent of disease may be associated with CRP and/or albumin in patients with moderate
to severe severity. However, the authors did not mention this content in the present manuscript.
The authors should present median (or mean) CAR in patients with each MES and should
compare the differences among MES 0, 1,2, or 3.
Why did the authors divide into 3 categories about CAR? How was the cut-off value determined?
Also, what is the reason for deciding 7 years a cut-off value?
assistant