Reviewer's report
Title:Usefulness and safety of 0.4 percent sodium hyaluronate solution as a
submucosal fluid acushiona for endoscopic resection of colorectal mucosal
neoplasms: A prospective multi-center open-label trial
Version: 1Date:16 March 2008
Reviewer: Hans Herfarth
Reviewer's report:
The authors report the first experience with 0.4% sodium hyaluronate (SH)
injections prior to endoscopic resections of colonic mucosal neoplasms in a
prospective multi-center study.
Comments:
Overall the paper is well written and might provide a basis for a prospective trial
comparing the clinical usefulness of SH injections to saline injections.
The authors should clarify the final concentration of the 0.4% SH, since
epinephrine and indigo carmine were added to the solution at the discretion of
the endoscopist. They should at least be able to give a range of the final
concentration of SH (or an estimate).
Figure 1: What happened to the 6 incomplete resections described in figure 1 but
not in the result section?
Figure 2 does not add additional information. The numbers are already presented
in table 4.
Table 1 and Table 6 are difficult to comprehend (even with the table description).
The tables should be better presented. Table 6: What does variable (n=41) stand
for. Since only 40 patients were evaluated, (1 patient was excluded due to
exclusion criteria as presented in figure 1)
Minor:
The English grammar and the wording are sometimes wrong or awkward.
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Usefulness and safety of 0.4 percent sodium hyaluronate solution as a
submucosal fluid acushiona for endoscopic resection of colorectal mucosal
neoplasms: A prospective multi-center open-label trial
Version: 1Date:16 March 2008
Reviewer: Hans Herfarth
Reviewer's report:
The authors report the first experience with 0.4% sodium hyaluronate (SH)
injections prior to endoscopic resections of colonic mucosal neoplasms in a
prospective multi-center study.
Comments:
Overall the paper is well written and might provide a basis for a prospective trial
comparing the clinical usefulness of SH injections to saline injections.
The authors should clarify the final concentration of the 0.4% SH, since
epinephrine and indigo carmine were added to the solution at the discretion of
the endoscopist. They should at least be able to give a range of the final
concentration of SH (or an estimate).
Figure 1: What happened to the 6 incomplete resections described in figure 1 but
not in the result section?
Figure 2 does not add additional information. The numbers are already presented
in table 4.
Table 1 and Table 6 are difficult to comprehend (even with the table description).
The tables should be better presented. Table 6: What does variable (n=41) stand
for. Since only 40 patients were evaluated, (1 patient was excluded due to
exclusion criteria as presented in figure 1)
Minor:
The English grammar and the wording are sometimes wrong or awkward.
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Usefulness and safety of 0.4 percent sodium hyaluronate solution as a
submucosal fluid acushiona for endoscopic resection of colorectal mucosal
neoplasms: A prospective multi-center open-label trial
Version: 1Date:16 March 2008
Reviewer: Hans Herfarth
Reviewer's report:
The authors report the first experience with 0.4% sodium hyaluronate (SH)
injections prior to endoscopic resections of colonic mucosal neoplasms in a
prospective multi-center study.
Comments:
Overall the paper is well written and might provide a basis for a prospective trial
comparing the clinical usefulness of SH injections to saline injections.
The authors should clarify the final concentration of the 0.4% SH, since
epinephrine and indigo carmine were added to the solution at the discretion of
the endoscopist. They should at least be able to give a range of the final
concentration of SH (or an estimate).
Figure 1: What happened to the 6 incomplete resections described in figure 1 but
not in the result section?
Figure 2 does not add additional information. The numbers are already presented
in table 4.
Table 1 and Table 6 are difficult to comprehend (even with the table description).
The tables should be better presented. Table 6: What does variable (n=41) stand
for. Since only 40 patients were evaluated, (1 patient was excluded due to
exclusion criteria as presented in figure 1)
Minor:
The English grammar and the wording are sometimes wrong or awkward.
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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