Title: The prognostic role of albumin-bilirubin grade in the mortality of extrahepatic
cholangiocarcinoma patients
Version: 1 Date: 30 Mar 2025
Reviewer's report:
This article was satisfactory revised after suggestion. Nevertheless, it is suggested that some
recommendations enhance the caliber of this endeavor.
1. Explain the definition of the types of eCCA, in the table the author divided into distal,
proximal, hilar type. How about the surgical procedure, in all types have done by Whipple
operation (Pancreaticoduodenectomy)? No liver resection?
Reply by the author(s) : eCCA consists of perihilar cholangiocarcinoma and distal eCCA
(involving all parts of the common bile duct). Based on the site of involvement, patients
underwent either pancreatoduodenectomy or segmental biliary resection. Patients with
perihilar CCA who underwent en bloc resection of the bile duct, with or without regional
lymphadenectomy and with or without lobectomy, were included in the study. Patients with
perihilar involvement who underwent liver transplantation were excluded from the study.
Comments:  In the inclusion criteria, the author already removed the specific operative procedure
“Whipple operation” and replaced by “surgery”.
To complete this statement by adding the exclusion criteria in study population (Page 4 Line 6) :
Patients with perihilar involvement who underwent liver transplantation were excluded from
the study.
Title: The prognostic role of albumin-bilirubin grade in the mortality of extrahepatic
cholangiocarcinoma patients
Version: 1 Date: 30 Mar 2025
Reviewer's report:
This article was satisfactory revised after suggestion. Nevertheless, it is suggested that some
recommendations enhance the caliber of this endeavor.
1. Explain the definition of the types of eCCA, in the table the author divided into distal,
proximal, hilar type. How about the surgical procedure, in all types have done by Whipple
operation (Pancreaticoduodenectomy)? No liver resection?
Reply by the author(s) : eCCA consists of perihilar cholangiocarcinoma and distal eCCA
(involving all parts of the common bile duct). Based on the site of involvement, patients
underwent either pancreatoduodenectomy or segmental biliary resection. Patients with
perihilar CCA who underwent en bloc resection of the bile duct, with or without regional
lymphadenectomy and with or without lobectomy, were included in the study. Patients with
perihilar involvement who underwent liver transplantation were excluded from the study.
Comments:  In the inclusion criteria, the author already removed the specific operative procedure
“Whipple operation” and replaced by “surgery”.
To complete this statement by adding the exclusion criteria in study population (Page 4 Line 6) :
Patients with perihilar involvement who underwent liver transplantation were excluded from
the study.
Please review this paper.
user
Title: The prognostic role of albumin-bilirubin grade in the mortality of extrahepatic
cholangiocarcinoma patients
Version: 1 Date: 30 Mar 2025
Reviewer's report:
This article was satisfactory revised after suggestion. Nevertheless, it is suggested that some
recommendations enhance the caliber of this endeavor.
1. Explain the definition of the types of eCCA, in the table the author divided into distal,
proximal, hilar type. How about the surgical procedure, in all types have done by Whipple
operation (Pancreaticoduodenectomy)? No liver resection?
Reply by the author(s) : eCCA consists of perihilar cholangiocarcinoma and distal eCCA
(involving all parts of the common bile duct). Based on the site of involvement, patients
underwent either pancreatoduodenectomy or segmental biliary resection. Patients with
perihilar CCA who underwent en bloc resection of the bile duct, with or without regional
lymphadenectomy and with or without lobectomy, were included in the study. Patients with
perihilar involvement who underwent liver transplantation were excluded from the study.
Comments:  In the inclusion criteria, the author already removed the specific operative procedure
“Whipple operation” and replaced by “surgery”.
To complete this statement by adding the exclusion criteria in study population (Page 4 Line 6) :
Patients with perihilar involvement who underwent liver transplantation were excluded from
the study.
assistant