Reviewer's report
Title:Elevated circulating soluble interleukin-2 receptor in patients with chronic
liver diseases is associated with non-classical monocytes
Version: 1Date:19 March 2012
Reviewer: Jaap Kwekkeboom
Reviewer's report:
Major Compulsory Revisions:
1. The authors should include a statistical comparison of the numbers of
monocytes, classical monocytes, pro-inflammatory monocytes between patients
and healthy controls, preferably in an additional figure. In the current version the
numbers are mentioned in Table 1, but no statistics is provided.
2. The authors should explain why they focused on sIL2R, while a large
number of cytokines and chemokines seem also to be elevated in CLD-patients
according to Table 2. Are differences in these parameters smaller between
CLD-patients and healthy subjects, or between cirrhotic and non-cirrhotic
patients?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Elevated circulating soluble interleukin-2 receptor in patients with chronic
liver diseases is associated with non-classical monocytes
Version: 1Date:19 March 2012
Reviewer: Jaap Kwekkeboom
Reviewer's report:
Major Compulsory Revisions:
1. The authors should include a statistical comparison of the numbers of
monocytes, classical monocytes, pro-inflammatory monocytes between patients
and healthy controls, preferably in an additional figure. In the current version the
numbers are mentioned in Table 1, but no statistics is provided.
2. The authors should explain why they focused on sIL2R, while a large
number of cytokines and chemokines seem also to be elevated in CLD-patients
according to Table 2. Are differences in these parameters smaller between
CLD-patients and healthy subjects, or between cirrhotic and non-cirrhotic
patients?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Elevated circulating soluble interleukin-2 receptor in patients with chronic
liver diseases is associated with non-classical monocytes
Version: 1Date:19 March 2012
Reviewer: Jaap Kwekkeboom
Reviewer's report:
Major Compulsory Revisions:
1. The authors should include a statistical comparison of the numbers of
monocytes, classical monocytes, pro-inflammatory monocytes between patients
and healthy controls, preferably in an additional figure. In the current version the
numbers are mentioned in Table 1, but no statistics is provided.
2. The authors should explain why they focused on sIL2R, while a large
number of cytokines and chemokines seem also to be elevated in CLD-patients
according to Table 2. Are differences in these parameters smaller between
CLD-patients and healthy subjects, or between cirrhotic and non-cirrhotic
patients?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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