Reviewer's report
Title:Different healing process of esophageal large mucosal defects by
endoscopic mucosal dissection between with and without steroid injection in an
animal model
Version: 1Date:23 January 2013
Reviewer: Satoshi Ono
Reviewer's report:
This manuscript is written about histopathological process forming postoperative
stricture after esophageal ESD with and without local injection of steroid. It
seems very interesting and helpful for further investigation about prevention of
postoperative stricture. However, it has some problems before acceptance in its
present form.
Major point:
1. A number of pig with local injection of steroid is too small. It seems preferable
to treat more pigs with local injection of steroid. If authors want to evaluate
histopathological effect of steroid local injection, specimen of pigs one and three
weeks after ESD with steroid local injection is necessary.
2. Was it necessary to treat pigs with circumferential ESD? To evaluate only
histopathological changes after ESD, circumferential ESD is not necessarily
required. Authors could have evaluated more specimens from a single pig if they
had performed multisessions of focal ESDs in a single pig.
Minor point:
1. A pig with steroid local injection underwent multiple sessions of balloon
dilatations. Balloon dilatations might have effects upon histopathological
assessment of specimen from this pig.
2. It is preferable to show quantitative pathological findings as graphs in
chronological order.
3. It seems unusual that diameter of GIF-Q240 is written in Result section, not in
Material and Method section.
4. Please mention recommendation about timing or dosage of steroid injection to
prevent postoperative stricture if possible.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Different healing process of esophageal large mucosal defects by
endoscopic mucosal dissection between with and without steroid injection in an
animal model
Version: 1Date:23 January 2013
Reviewer: Satoshi Ono
Reviewer's report:
This manuscript is written about histopathological process forming postoperative
stricture after esophageal ESD with and without local injection of steroid. It
seems very interesting and helpful for further investigation about prevention of
postoperative stricture. However, it has some problems before acceptance in its
present form.
Major point:
1. A number of pig with local injection of steroid is too small. It seems preferable
to treat more pigs with local injection of steroid. If authors want to evaluate
histopathological effect of steroid local injection, specimen of pigs one and three
weeks after ESD with steroid local injection is necessary.
2. Was it necessary to treat pigs with circumferential ESD? To evaluate only
histopathological changes after ESD, circumferential ESD is not necessarily
required. Authors could have evaluated more specimens from a single pig if they
had performed multisessions of focal ESDs in a single pig.
Minor point:
1. A pig with steroid local injection underwent multiple sessions of balloon
dilatations. Balloon dilatations might have effects upon histopathological
assessment of specimen from this pig.
2. It is preferable to show quantitative pathological findings as graphs in
chronological order.
3. It seems unusual that diameter of GIF-Q240 is written in Result section, not in
Material and Method section.
4. Please mention recommendation about timing or dosage of steroid injection to
prevent postoperative stricture if possible.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Different healing process of esophageal large mucosal defects by
endoscopic mucosal dissection between with and without steroid injection in an
animal model
Version: 1Date:23 January 2013
Reviewer: Satoshi Ono
Reviewer's report:
This manuscript is written about histopathological process forming postoperative
stricture after esophageal ESD with and without local injection of steroid. It
seems very interesting and helpful for further investigation about prevention of
postoperative stricture. However, it has some problems before acceptance in its
present form.
Major point:
1. A number of pig with local injection of steroid is too small. It seems preferable
to treat more pigs with local injection of steroid. If authors want to evaluate
histopathological effect of steroid local injection, specimen of pigs one and three
weeks after ESD with steroid local injection is necessary.
2. Was it necessary to treat pigs with circumferential ESD? To evaluate only
histopathological changes after ESD, circumferential ESD is not necessarily
required. Authors could have evaluated more specimens from a single pig if they
had performed multisessions of focal ESDs in a single pig.
Minor point:
1. A pig with steroid local injection underwent multiple sessions of balloon
dilatations. Balloon dilatations might have effects upon histopathological
assessment of specimen from this pig.
2. It is preferable to show quantitative pathological findings as graphs in
chronological order.
3. It seems unusual that diameter of GIF-Q240 is written in Result section, not in
Material and Method section.
4. Please mention recommendation about timing or dosage of steroid injection to
prevent postoperative stricture if possible.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant