Title: Clinical features and images of malignant lymphoma localized in the pancreatic head to
differentiate from pancreatic ductal adenocarcinoma: A case series study.
Version: 2 Date: 24 Mar 2023
Reviewer:  Thomas Togliani
Reviewer's report:
This is  an interesting report on the role of imaging techniques and biochemistry to differentiate
pancreatic lymphoma from PDAC. The topic is original and the clinical outcomes seem
attractive.
The only remark I have is that the additional diagnostic role of these information should not be
compared to EUS-guided FNA but to FNB. In fact, the histological and immunohistochemical
capabilities of FNB currently represent the diagnostic gold standard for pancreatic masses
(PDAC, lymphoma, NETs, autoimmune pancreatitis); moreover, EUS elastography and
contrast-enhanced EUS could give a further help in the differential dignosis of pancreatic
masses.
Thus, the relevance of the described clinical and imaging data could be slightly reduced when
compared to the currently available high-quality EUS procedures.
Title: Clinical features and images of malignant lymphoma localized in the pancreatic head to
differentiate from pancreatic ductal adenocarcinoma: A case series study.
Version: 2 Date: 24 Mar 2023
Reviewer:  Thomas Togliani
Reviewer's report:
This is  an interesting report on the role of imaging techniques and biochemistry to differentiate
pancreatic lymphoma from PDAC. The topic is original and the clinical outcomes seem
attractive.
The only remark I have is that the additional diagnostic role of these information should not be
compared to EUS-guided FNA but to FNB. In fact, the histological and immunohistochemical
capabilities of FNB currently represent the diagnostic gold standard for pancreatic masses
(PDAC, lymphoma, NETs, autoimmune pancreatitis); moreover, EUS elastography and
contrast-enhanced EUS could give a further help in the differential dignosis of pancreatic
masses.
Thus, the relevance of the described clinical and imaging data could be slightly reduced when
compared to the currently available high-quality EUS procedures.
Please review this paper.
user
Title: Clinical features and images of malignant lymphoma localized in the pancreatic head to
differentiate from pancreatic ductal adenocarcinoma: A case series study.
Version: 2 Date: 24 Mar 2023
Reviewer:  Thomas Togliani
Reviewer's report:
This is  an interesting report on the role of imaging techniques and biochemistry to differentiate
pancreatic lymphoma from PDAC. The topic is original and the clinical outcomes seem
attractive.
The only remark I have is that the additional diagnostic role of these information should not be
compared to EUS-guided FNA but to FNB. In fact, the histological and immunohistochemical
capabilities of FNB currently represent the diagnostic gold standard for pancreatic masses
(PDAC, lymphoma, NETs, autoimmune pancreatitis); moreover, EUS elastography and
contrast-enhanced EUS could give a further help in the differential dignosis of pancreatic
masses.
Thus, the relevance of the described clinical and imaging data could be slightly reduced when
compared to the currently available high-quality EUS procedures.
assistant