Reviewer's report
Title:Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-b
(beta)and fibrotic proteins
Version: 3Date:18 August 2009
Reviewer: Ian Hines
Reviewer's report:
While the authors verbally addressed my concerns, additional data was not
included. Cell localization of Smad7 expression as well as alternative approaches
to stain collagen would greatly strengthen the manuscript and increase its
impact. In the current form, this manuscript is very descriptive and falls
somewhat short of defining a role for Smad7 in cholestasis associated liver
fibrosis in humans.
Nevertheless, it is the first report to my knowledge to measure Smad7 expression
in human liver samples in this setting. It may provide a springboard for
subsequent studies to define a role for Smad7 in human liver fibrosis, a clinically
relevant problem and potential therapeutic target. For this reason, I find the
article acceptable in the current form for publication.
Reviewer's report
Title:Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-b
(beta)and fibrotic proteins
Version: 3Date:18 August 2009
Reviewer: Ian Hines
Reviewer's report:
While the authors verbally addressed my concerns, additional data was not
included. Cell localization of Smad7 expression as well as alternative approaches
to stain collagen would greatly strengthen the manuscript and increase its
impact. In the current form, this manuscript is very descriptive and falls
somewhat short of defining a role for Smad7 in cholestasis associated liver
fibrosis in humans.
Nevertheless, it is the first report to my knowledge to measure Smad7 expression
in human liver samples in this setting. It may provide a springboard for
subsequent studies to define a role for Smad7 in human liver fibrosis, a clinically
relevant problem and potential therapeutic target. For this reason, I find the
article acceptable in the current form for publication.
Please review this paper.
user
Reviewer's report
Title:Liver fibrosis secondary to bile duct injury: correlation of Smad7 with TGF-b
(beta)and fibrotic proteins
Version: 3Date:18 August 2009
Reviewer: Ian Hines
Reviewer's report:
While the authors verbally addressed my concerns, additional data was not
included. Cell localization of Smad7 expression as well as alternative approaches
to stain collagen would greatly strengthen the manuscript and increase its
impact. In the current form, this manuscript is very descriptive and falls
somewhat short of defining a role for Smad7 in cholestasis associated liver
fibrosis in humans.
Nevertheless, it is the first report to my knowledge to measure Smad7 expression
in human liver samples in this setting. It may provide a springboard for
subsequent studies to define a role for Smad7 in human liver fibrosis, a clinically
relevant problem and potential therapeutic target. For this reason, I find the
article acceptable in the current form for publication.
assistant