Title: Long term changes in thrombocytopenia and leucopenia after HCV eradication with
direct-acting antivirals
Version: 2 Date: 26 Dec 2022
Reviewer's report:
the statistical analysis of the data is correct.
the article deals with an important topic, but as a limitation it is a retrospective work. It is not
clear whether these patients had liver damage resulting only from HCV or whether there were
other viruses (e.g. HBV)
Is the group that presents a reduction in platelets the one that starts with the greatest
hypersplenism?
It is not clear to me whether this improvement is observed in subjects with severe hepatic
damage or severe porta hypertension. Does it also occur in subjects who have had an episode
of decompensation?
Title: Long term changes in thrombocytopenia and leucopenia after HCV eradication with
direct-acting antivirals
Version: 2 Date: 26 Dec 2022
Reviewer's report:
the statistical analysis of the data is correct.
the article deals with an important topic, but as a limitation it is a retrospective work. It is not
clear whether these patients had liver damage resulting only from HCV or whether there were
other viruses (e.g. HBV)
Is the group that presents a reduction in platelets the one that starts with the greatest
hypersplenism?
It is not clear to me whether this improvement is observed in subjects with severe hepatic
damage or severe porta hypertension. Does it also occur in subjects who have had an episode
of decompensation?
Please review this paper.
user
Title: Long term changes in thrombocytopenia and leucopenia after HCV eradication with
direct-acting antivirals
Version: 2 Date: 26 Dec 2022
Reviewer's report:
the statistical analysis of the data is correct.
the article deals with an important topic, but as a limitation it is a retrospective work. It is not
clear whether these patients had liver damage resulting only from HCV or whether there were
other viruses (e.g. HBV)
Is the group that presents a reduction in platelets the one that starts with the greatest
hypersplenism?
It is not clear to me whether this improvement is observed in subjects with severe hepatic
damage or severe porta hypertension. Does it also occur in subjects who have had an episode
of decompensation?
assistant