Title: Impact of Terminal Ileal Microbiota Dysbiosis and Tryptophan Metabolism Alterations
on Mental disorders in Patients with Crohn's Disease
Version: 5 Date: 23 Apr 2025
Reviewer's report:
The size of the study group (41) does not quite match the control group (11). I do not quite
understand why the control group is made up of people with cancer or could it not be people
with, for example, IBS?
No information appears about the non-surgical treatment of the qualified patients, and this may
also have an impact on the microbiota.
Overall the study is extremely interesting, it would be worth extending it on a larger sample.
Title: Impact of Terminal Ileal Microbiota Dysbiosis and Tryptophan Metabolism Alterations
on Mental disorders in Patients with Crohn's Disease
Version: 5 Date: 23 Apr 2025
Reviewer's report:
The size of the study group (41) does not quite match the control group (11). I do not quite
understand why the control group is made up of people with cancer or could it not be people
with, for example, IBS?
No information appears about the non-surgical treatment of the qualified patients, and this may
also have an impact on the microbiota.
Overall the study is extremely interesting, it would be worth extending it on a larger sample.
Please review this paper.
user
Title: Impact of Terminal Ileal Microbiota Dysbiosis and Tryptophan Metabolism Alterations
on Mental disorders in Patients with Crohn's Disease
Version: 5 Date: 23 Apr 2025
Reviewer's report:
The size of the study group (41) does not quite match the control group (11). I do not quite
understand why the control group is made up of people with cancer or could it not be people
with, for example, IBS?
No information appears about the non-surgical treatment of the qualified patients, and this may
also have an impact on the microbiota.
Overall the study is extremely interesting, it would be worth extending it on a larger sample.
assistant