Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do
not contribute to clinical presentation of acquired fructose malabsorption.
Version: 3 Date: 24 Mar 2022
Reviewer:  B. Yan
Reviewer's report:
This is an interesting genetic study with a small group of samples. Basically, authors tried to
investigated the genetics of acquired fructose malabsorption. SLC2A5 gene encoding GLUT5
was analyzed in 35 patients. Ten genetic variants were identified, frequencies of which in this
group of patients were similar to that in general population in  public database. Therefore, author
concluded that genetic variants of SLC2A5 gene, including coding exons, adjacent intronic
regions and proximal promoter region,  are unlikely to contribute to genetic predisposition of
acquired fructose malabsorption. Though negative results were presented here, the data would
provide a piece fo new information. In addition,  the column "Different conditions  from standard
protocol" In Table 2 might be left out, which did not added much information.
Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do
not contribute to clinical presentation of acquired fructose malabsorption.
Version: 3 Date: 24 Mar 2022
Reviewer:  B. Yan
Reviewer's report:
This is an interesting genetic study with a small group of samples. Basically, authors tried to
investigated the genetics of acquired fructose malabsorption. SLC2A5 gene encoding GLUT5
was analyzed in 35 patients. Ten genetic variants were identified, frequencies of which in this
group of patients were similar to that in general population in  public database. Therefore, author
concluded that genetic variants of SLC2A5 gene, including coding exons, adjacent intronic
regions and proximal promoter region,  are unlikely to contribute to genetic predisposition of
acquired fructose malabsorption. Though negative results were presented here, the data would
provide a piece fo new information. In addition,  the column "Different conditions  from standard
protocol" In Table 2 might be left out, which did not added much information.
Please review this paper.
user
Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do
not contribute to clinical presentation of acquired fructose malabsorption.
Version: 3 Date: 24 Mar 2022
Reviewer:  B. Yan
Reviewer's report:
This is an interesting genetic study with a small group of samples. Basically, authors tried to
investigated the genetics of acquired fructose malabsorption. SLC2A5 gene encoding GLUT5
was analyzed in 35 patients. Ten genetic variants were identified, frequencies of which in this
group of patients were similar to that in general population in  public database. Therefore, author
concluded that genetic variants of SLC2A5 gene, including coding exons, adjacent intronic
regions and proximal promoter region,  are unlikely to contribute to genetic predisposition of
acquired fructose malabsorption. Though negative results were presented here, the data would
provide a piece fo new information. In addition,  the column "Different conditions  from standard
protocol" In Table 2 might be left out, which did not added much information.
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