Reviewer's report
Title:FibroSURE as a Noninvasive Marker of Liver Fibrosis and Inflammation in
Chronic Hepatitis B
Version:2Date:12 May 2014
Reviewer: donald D. anthony
Reviewer's report:
This data set is a nice contribution to our understanding of the meaning of these
serum biomarker tests in the evaluation for liver damage in HBV infected
patients.
1. Abstract: the description of the patient population would be more appropriately
placed in the results instead of methods.
2. Results: it would be helpful to understand how this test performs in
HBV+HIVnegative individuals and in HIV+HBV+. The clinician will most likely
know HIV infection status prior to performing this test, and adding HIV status to
the test may not provide a clinically useful scenario. Perhaps the sample size for
HIV negative subjects is large enough to comment in this regard.
3. Discussion: it would be helpful for the reader if the authors compared
effectiveness of this test they observe in HBV infection with that previously
published during HCV infection. Is it better, worse, or the same?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interests
Reviewer's report
Title:FibroSURE as a Noninvasive Marker of Liver Fibrosis and Inflammation in
Chronic Hepatitis B
Version:2Date:12 May 2014
Reviewer: donald D. anthony
Reviewer's report:
This data set is a nice contribution to our understanding of the meaning of these
serum biomarker tests in the evaluation for liver damage in HBV infected
patients.
1. Abstract: the description of the patient population would be more appropriately
placed in the results instead of methods.
2. Results: it would be helpful to understand how this test performs in
HBV+HIVnegative individuals and in HIV+HBV+. The clinician will most likely
know HIV infection status prior to performing this test, and adding HIV status to
the test may not provide a clinically useful scenario. Perhaps the sample size for
HIV negative subjects is large enough to comment in this regard.
3. Discussion: it would be helpful for the reader if the authors compared
effectiveness of this test they observe in HBV infection with that previously
published during HCV infection. Is it better, worse, or the same?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interests
Please review this paper.
user
Reviewer's report
Title:FibroSURE as a Noninvasive Marker of Liver Fibrosis and Inflammation in
Chronic Hepatitis B
Version:2Date:12 May 2014
Reviewer: donald D. anthony
Reviewer's report:
This data set is a nice contribution to our understanding of the meaning of these
serum biomarker tests in the evaluation for liver damage in HBV infected
patients.
1. Abstract: the description of the patient population would be more appropriately
placed in the results instead of methods.
2. Results: it would be helpful to understand how this test performs in
HBV+HIVnegative individuals and in HIV+HBV+. The clinician will most likely
know HIV infection status prior to performing this test, and adding HIV status to
the test may not provide a clinically useful scenario. Perhaps the sample size for
HIV negative subjects is large enough to comment in this regard.
3. Discussion: it would be helpful for the reader if the authors compared
effectiveness of this test they observe in HBV infection with that previously
published during HCV infection. Is it better, worse, or the same?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interests
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