Title: Analysis of the distribution characteristics of pathogenic bacteria in the wound tissue of
patients with perianal abscess combined with infection and the influencing factors of wound
healing
Version: 3 Date: 26 Jan 2025
Reviewer's report:
In introduction:
Some points are repeated, such as the mention of bacterial infections and specific pathogens like
E. coli and K. pneumoniae. These could be consolidated to avoid redundancy
while the study's purpose is mentioned, the specific gap in the current literature that this study
aims to fill is not clear.
There are minor typographical and grammatical errors, such as inconsistent use of spaces
before and after parentheses (e.g., Escherichia coli(E. coli) and Klebsiella pneumoniae(K.
pneumoniae)).
Method:
Factors like smoking, alcohol use, and personal hygiene are not included in the data collection
but could significantly affect infection rates and wound healing. These lifestyle factors could be
important to identify as risk factors. If there are this data, please consider it.
Discussion:
the mechanisms through which diabetes impacts wound healing are well-detailed, please
describe the causal relationship between diabetes and wound healing in perianal abscesses could
be more clearly established.
In conclusion: Given the prevalence of Gram-negative bacteria and the potential for
antimicrobial resistance (especially in the context of E. coli and K. pneumoniae), it would be
important to mention the implications of antibiotic resistance.
Title: Analysis of the distribution characteristics of pathogenic bacteria in the wound tissue of
patients with perianal abscess combined with infection and the influencing factors of wound
healing
Version: 3 Date: 26 Jan 2025
Reviewer's report:
In introduction:
Some points are repeated, such as the mention of bacterial infections and specific pathogens like
E. coli and K. pneumoniae. These could be consolidated to avoid redundancy
while the study's purpose is mentioned, the specific gap in the current literature that this study
aims to fill is not clear.
There are minor typographical and grammatical errors, such as inconsistent use of spaces
before and after parentheses (e.g., Escherichia coli(E. coli) and Klebsiella pneumoniae(K.
pneumoniae)).
Method:
Factors like smoking, alcohol use, and personal hygiene are not included in the data collection
but could significantly affect infection rates and wound healing. These lifestyle factors could be
important to identify as risk factors. If there are this data, please consider it.
Discussion:
the mechanisms through which diabetes impacts wound healing are well-detailed, please
describe the causal relationship between diabetes and wound healing in perianal abscesses could
be more clearly established.
In conclusion: Given the prevalence of Gram-negative bacteria and the potential for
antimicrobial resistance (especially in the context of E. coli and K. pneumoniae), it would be
important to mention the implications of antibiotic resistance.
Please review this paper.
user
Title: Analysis of the distribution characteristics of pathogenic bacteria in the wound tissue of
patients with perianal abscess combined with infection and the influencing factors of wound
healing
Version: 3 Date: 26 Jan 2025
Reviewer's report:
In introduction:
Some points are repeated, such as the mention of bacterial infections and specific pathogens like
E. coli and K. pneumoniae. These could be consolidated to avoid redundancy
while the study's purpose is mentioned, the specific gap in the current literature that this study
aims to fill is not clear.
There are minor typographical and grammatical errors, such as inconsistent use of spaces
before and after parentheses (e.g., Escherichia coli(E. coli) and Klebsiella pneumoniae(K.
pneumoniae)).
Method:
Factors like smoking, alcohol use, and personal hygiene are not included in the data collection
but could significantly affect infection rates and wound healing. These lifestyle factors could be
important to identify as risk factors. If there are this data, please consider it.
Discussion:
the mechanisms through which diabetes impacts wound healing are well-detailed, please
describe the causal relationship between diabetes and wound healing in perianal abscesses could
be more clearly established.
In conclusion: Given the prevalence of Gram-negative bacteria and the potential for
antimicrobial resistance (especially in the context of E. coli and K. pneumoniae), it would be
important to mention the implications of antibiotic resistance.
assistant