Reviewer ’s report  
 
Title: Dietary treatment of Crohn's Disease: Perceptions of families with children treated by 
exclusive enteral nutrition, a  questionnaire survey  
 
Version: 2 Date: 04 Oct 2016  
 
Reviewer: Victor Navas  
 
Reviewer's report:  
 
This is an original paper where the authors exposed the perceptions of families with children 
treated by exclusive enteral nutrition. The information was obtained by a anonymous 
questionnaire survey. In my opinion this is a very well w ritten paper and to my knowledge one of 
the first who explores this area of exclusive enteral nutrition. There are some minor comments I 
would like to share with the authors:  
1. Anonymous: in my opinion this is not the best way to get the information. The vision, 
perceptions and concerns about Crohn´s disease are very dependent on the patient and their 
family. So,  it could be better to know who was answering the questionnaire. I would like the 
authors explain why they chose an anonymous aproach. Do you hav e data about QOL?  
2. EEN protocol: For a better understanding, please, could you explain briefly how is your EEN 
protocol? visits, enteral formula most used, nasogastric tube protocol, etc.  
3. Intructions to patients and parents: No instructions were given  to parents and patients. An 
explanation of the high correlation you found could be because they completed the 
questionnaire together. Please discuss this point.  
 
Minor changes  
1. Page 7. Line 20. Median (IQR): perhaps some data are missed for the IQR  
 
Thank you  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the autho rs. 
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the edit ors. 
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following ques tions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or  shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree t o the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Dietary treatment of Crohn's Disease: Perceptions of families with children treated by 
exclusive enteral nutrition, a  questionnaire survey  
 
Version: 2 Date: 04 Oct 2016  
 
Reviewer: Victor Navas  
 
Reviewer's report:  
 
This is an original paper where the authors exposed the perceptions of families with children 
treated by exclusive enteral nutrition. The information was obtained by a anonymous 
questionnaire survey. In my opinion this is a very well w ritten paper and to my knowledge one of 
the first who explores this area of exclusive enteral nutrition. There are some minor comments I 
would like to share with the authors:  
1. Anonymous: in my opinion this is not the best way to get the information. The vision, 
perceptions and concerns about Crohn´s disease are very dependent on the patient and their 
family. So,  it could be better to know who was answering the questionnaire. I would like the 
authors explain why they chose an anonymous aproach. Do you hav e data about QOL?  
2. EEN protocol: For a better understanding, please, could you explain briefly how is your EEN 
protocol? visits, enteral formula most used, nasogastric tube protocol, etc.  
3. Intructions to patients and parents: No instructions were given  to parents and patients. An 
explanation of the high correlation you found could be because they completed the 
questionnaire together. Please discuss this point.  
 
Minor changes  
1. Page 7. Line 20. Median (IQR): perhaps some data are missed for the IQR  
 
Thank you  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the autho rs. 
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the edit ors. 
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following ques tions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or  shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree t o the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Dietary treatment of Crohn's Disease: Perceptions of families with children treated by 
exclusive enteral nutrition, a  questionnaire survey  
 
Version: 2 Date: 04 Oct 2016  
 
Reviewer: Victor Navas  
 
Reviewer's report:  
 
This is an original paper where the authors exposed the perceptions of families with children 
treated by exclusive enteral nutrition. The information was obtained by a anonymous 
questionnaire survey. In my opinion this is a very well w ritten paper and to my knowledge one of 
the first who explores this area of exclusive enteral nutrition. There are some minor comments I 
would like to share with the authors:  
1. Anonymous: in my opinion this is not the best way to get the information. The vision, 
perceptions and concerns about Crohn´s disease are very dependent on the patient and their 
family. So,  it could be better to know who was answering the questionnaire. I would like the 
authors explain why they chose an anonymous aproach. Do you hav e data about QOL?  
2. EEN protocol: For a better understanding, please, could you explain briefly how is your EEN 
protocol? visits, enteral formula most used, nasogastric tube protocol, etc.  
3. Intructions to patients and parents: No instructions were given  to parents and patients. An 
explanation of the high correlation you found could be because they completed the 
questionnaire together. Please discuss this point.  
 
Minor changes  
1. Page 7. Line 20. Median (IQR): perhaps some data are missed for the IQR  
 
Thank you  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the autho rs. 
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the edit ors. 
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following ques tions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or  shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree t o the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant