Reviewer's report
Title:New PRSS1 and common CFTR mutations in a child with acute recurrent
pancreatitis, could be considered an "Hereditary" form of pancreatitis ?
Version: 3Date:1 June 2010
Reviewer: Atsushi Masamune
Reviewer's report:
Major Compulsory Revisions
The authors have well revised the manuscript. But, again, in the absence of
functional study, the role of p.S181G variant in the PRSS1 (which exists with teh
known disease-causing CFTR mutation) remains obscure. Although no carrier
was detected in 100 (is this sufficinet number ?) healthy controls, it does not
mean that the p.S181G varaint is a really disease-causing or disease-modifying
mutation.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:New PRSS1 and common CFTR mutations in a child with acute recurrent
pancreatitis, could be considered an "Hereditary" form of pancreatitis ?
Version: 3Date:1 June 2010
Reviewer: Atsushi Masamune
Reviewer's report:
Major Compulsory Revisions
The authors have well revised the manuscript. But, again, in the absence of
functional study, the role of p.S181G variant in the PRSS1 (which exists with teh
known disease-causing CFTR mutation) remains obscure. Although no carrier
was detected in 100 (is this sufficinet number ?) healthy controls, it does not
mean that the p.S181G varaint is a really disease-causing or disease-modifying
mutation.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:New PRSS1 and common CFTR mutations in a child with acute recurrent
pancreatitis, could be considered an "Hereditary" form of pancreatitis ?
Version: 3Date:1 June 2010
Reviewer: Atsushi Masamune
Reviewer's report:
Major Compulsory Revisions
The authors have well revised the manuscript. But, again, in the absence of
functional study, the role of p.S181G variant in the PRSS1 (which exists with teh
known disease-causing CFTR mutation) remains obscure. Although no carrier
was detected in 100 (is this sufficinet number ?) healthy controls, it does not
mean that the p.S181G varaint is a really disease-causing or disease-modifying
mutation.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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