Reviewer’s report
Title:  Three-hour post-ERCP amylase level: a useful indicator for early prediction of post-ERCP
pancreatitis
Version: 1 Date: 29 Sep 2019
Reviewer: Martin Freeman
Reviewer's report:
This is an important study, especially for the Western world, where same day discharge within 2-4
hours after ERCP has become standard. 
However, discharge and readmission after pancreatitis results in worse outcome
(SHOULD ADD THIS REFERENCE)
Development  and  Validation  of  a  Prediction  Model  for  Admission  After  Endoscopic  Retrograde
Cholangiopancreatography.
Coté GA, Lynch S, Easler JJ, Keen A, Vassell PA, Sherman S, Hui S, Xu H.
Clin  Gastroenterol  Hepatol.  2015  Dec;13(13):2323-32.e1-9.  doi:  10.1016/j.cgh.2015.06.023.  Epub
2015 Jun 27.
PMID: 26122761 
Pancreatitis can be moderately well predicted 
(SHOULD ADD THIS REFERENCE)
Risk factors for post-ERCP pancreatitis: a prospective, multicenter study.
Freeman ML, DiSario JA, Nelson DB, Fennerty MB, Lee JG, Bjorkman DJ, Overby CS, Aas J, Ryan
ME, Bochna GS, Shaw MJ, Snady HW, Erickson RV, Moore JP, Roel JP.
Gastrointest Endosc. 2001 Oct;54(4):425-34.
PMID: 11577302
Main limitation is small number of ERCPs performed during the study period, and small numbers of
patients with post ERCP pancreatitis.
However message is sufficiently important
Almost NO centers in the USA at least, perform routine measurement of post ERCP amylase/lipase
even in high risk patients, and this is a very reasonable option endorsed by this paper
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative Commons
CC-BY license (http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments
which I do not wish to be included in my named report can be included as confidential comments
to the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’s report
Title:  Three-hour post-ERCP amylase level: a useful indicator for early prediction of post-ERCP
pancreatitis
Version: 1 Date: 29 Sep 2019
Reviewer: Martin Freeman
Reviewer's report:
This is an important study, especially for the Western world, where same day discharge within 2-4
hours after ERCP has become standard. 
However, discharge and readmission after pancreatitis results in worse outcome
(SHOULD ADD THIS REFERENCE)
Development  and  Validation  of  a  Prediction  Model  for  Admission  After  Endoscopic  Retrograde
Cholangiopancreatography.
Coté GA, Lynch S, Easler JJ, Keen A, Vassell PA, Sherman S, Hui S, Xu H.
Clin  Gastroenterol  Hepatol.  2015  Dec;13(13):2323-32.e1-9.  doi:  10.1016/j.cgh.2015.06.023.  Epub
2015 Jun 27.
PMID: 26122761 
Pancreatitis can be moderately well predicted 
(SHOULD ADD THIS REFERENCE)
Risk factors for post-ERCP pancreatitis: a prospective, multicenter study.
Freeman ML, DiSario JA, Nelson DB, Fennerty MB, Lee JG, Bjorkman DJ, Overby CS, Aas J, Ryan
ME, Bochna GS, Shaw MJ, Snady HW, Erickson RV, Moore JP, Roel JP.
Gastrointest Endosc. 2001 Oct;54(4):425-34.
PMID: 11577302
Main limitation is small number of ERCPs performed during the study period, and small numbers of
patients with post ERCP pancreatitis.
However message is sufficiently important
Almost NO centers in the USA at least, perform routine measurement of post ERCP amylase/lipase
even in high risk patients, and this is a very reasonable option endorsed by this paper
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative Commons
CC-BY license (http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments
which I do not wish to be included in my named report can be included as confidential comments
to the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’s report
Title:  Three-hour post-ERCP amylase level: a useful indicator for early prediction of post-ERCP
pancreatitis
Version: 1 Date: 29 Sep 2019
Reviewer: Martin Freeman
Reviewer's report:
This is an important study, especially for the Western world, where same day discharge within 2-4
hours after ERCP has become standard. 
However, discharge and readmission after pancreatitis results in worse outcome
(SHOULD ADD THIS REFERENCE)
Development  and  Validation  of  a  Prediction  Model  for  Admission  After  Endoscopic  Retrograde
Cholangiopancreatography.
Coté GA, Lynch S, Easler JJ, Keen A, Vassell PA, Sherman S, Hui S, Xu H.
Clin  Gastroenterol  Hepatol.  2015  Dec;13(13):2323-32.e1-9.  doi:  10.1016/j.cgh.2015.06.023.  Epub
2015 Jun 27.
PMID: 26122761 
Pancreatitis can be moderately well predicted 
(SHOULD ADD THIS REFERENCE)
Risk factors for post-ERCP pancreatitis: a prospective, multicenter study.
Freeman ML, DiSario JA, Nelson DB, Fennerty MB, Lee JG, Bjorkman DJ, Overby CS, Aas J, Ryan
ME, Bochna GS, Shaw MJ, Snady HW, Erickson RV, Moore JP, Roel JP.
Gastrointest Endosc. 2001 Oct;54(4):425-34.
PMID: 11577302
Main limitation is small number of ERCPs performed during the study period, and small numbers of
patients with post ERCP pancreatitis.
However message is sufficiently important
Almost NO centers in the USA at least, perform routine measurement of post ERCP amylase/lipase
even in high risk patients, and this is a very reasonable option endorsed by this paper
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative Commons
CC-BY license (http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments
which I do not wish to be included in my named report can be included as confidential comments
to the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant