Title: The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in
alcohol-related liver disease: A cohort study.
Version: 1 Date: 26 Feb 2021
Reviewer's report:
Comment to the author:
Connoley, et al. have examined the diagnostic and prognostic performance of the Enhanced
Liver Fibrosis. The study provide us with important results in daily practice. However, there are
some concerns as listed below;
Study design is questionable. The time period between cohorts 2 and 3 is more than 10 years
apart. Because of the advances in treatment of cirrhosis, it raises concerns about examining the
prognosis of these two cohorts simultaneously. Cohort 1 was excluded, and the population of
cohort 2 is small. An analysis of cohort 2 alone would be show more truth. Is it possible to
analyze only cohort 2?
Title: The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in
alcohol-related liver disease: A cohort study.
Version: 1 Date: 26 Feb 2021
Reviewer's report:
Comment to the author:
Connoley, et al. have examined the diagnostic and prognostic performance of the Enhanced
Liver Fibrosis. The study provide us with important results in daily practice. However, there are
some concerns as listed below;
Study design is questionable. The time period between cohorts 2 and 3 is more than 10 years
apart. Because of the advances in treatment of cirrhosis, it raises concerns about examining the
prognosis of these two cohorts simultaneously. Cohort 1 was excluded, and the population of
cohort 2 is small. An analysis of cohort 2 alone would be show more truth. Is it possible to
analyze only cohort 2?
Please review this paper.
user
Title: The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in
alcohol-related liver disease: A cohort study.
Version: 1 Date: 26 Feb 2021
Reviewer's report:
Comment to the author:
Connoley, et al. have examined the diagnostic and prognostic performance of the Enhanced
Liver Fibrosis. The study provide us with important results in daily practice. However, there are
some concerns as listed below;
Study design is questionable. The time period between cohorts 2 and 3 is more than 10 years
apart. Because of the advances in treatment of cirrhosis, it raises concerns about examining the
prognosis of these two cohorts simultaneously. Cohort 1 was excluded, and the population of
cohort 2 is small. An analysis of cohort 2 alone would be show more truth. Is it possible to
analyze only cohort 2?
assistant