Title: Ultrasound-Derived Fat Fraction: A Novel Approach for Assessing Wilson's Disease-
Related Hepatic Steatosis
Version: 1 Date: 11 Mar 2025
Reviewer:  Ioan Sporea
Reviewer's report:
Very interesting paper, because the cohort of patients with this quite rare disease is very large.
To use NIT for fat assessment in such disease is very important for practice, maybe including the
screening of such rare disease. But the paper have one main concern: using a semi-quantitative
measurement like Hamaguchi score for steatosis quantification like a comparative method. MRI-
PDFF is now a substitutive for liver biopsy and maybe this is the ideal non-invasive method for
this comparison. Otherwise the paper is good, with good cohort of patients, with inter and intra-
observers variability. Only one mistake in the abstract (please correct!)
Title: Ultrasound-Derived Fat Fraction: A Novel Approach for Assessing Wilson's Disease-
Related Hepatic Steatosis
Version: 1 Date: 11 Mar 2025
Reviewer:  Ioan Sporea
Reviewer's report:
Very interesting paper, because the cohort of patients with this quite rare disease is very large.
To use NIT for fat assessment in such disease is very important for practice, maybe including the
screening of such rare disease. But the paper have one main concern: using a semi-quantitative
measurement like Hamaguchi score for steatosis quantification like a comparative method. MRI-
PDFF is now a substitutive for liver biopsy and maybe this is the ideal non-invasive method for
this comparison. Otherwise the paper is good, with good cohort of patients, with inter and intra-
observers variability. Only one mistake in the abstract (please correct!)
Please review this paper.
user
Title: Ultrasound-Derived Fat Fraction: A Novel Approach for Assessing Wilson's Disease-
Related Hepatic Steatosis
Version: 1 Date: 11 Mar 2025
Reviewer:  Ioan Sporea
Reviewer's report:
Very interesting paper, because the cohort of patients with this quite rare disease is very large.
To use NIT for fat assessment in such disease is very important for practice, maybe including the
screening of such rare disease. But the paper have one main concern: using a semi-quantitative
measurement like Hamaguchi score for steatosis quantification like a comparative method. MRI-
PDFF is now a substitutive for liver biopsy and maybe this is the ideal non-invasive method for
this comparison. Otherwise the paper is good, with good cohort of patients, with inter and intra-
observers variability. Only one mistake in the abstract (please correct!)
assistant