Reviewer’ s report
Title: Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular
carcinoma
Version: 1Date: 09 Jun 2020
Reviewer's report:
The authors of this study evaluated the peritumoral ductular reaction (PDR) in intrahepatic non-
mucing-producing cholangiocellular carcinoma and furthur investigated its correlations withScheuer scores in peritumor and normal liver tissues, proliferation activity of choloangiocytes,microenvironments, and prognosis. The results may help to understand the clinical significance ofPDR in cholangiocellular carcinoma. I have some comments as follows:1. The Abstract, especially the Results section, is too simple to cover the primary findings of thestudy. In the Results section, patients with significant PDR demonstrated a significantly worseprognosis but the authors did not mention which group of patients were compared to.2. Laboratory data, such as serum levels of albumin etc. were collected, but the correlationsbetween those data and PDR were not described.3. The clinicopathological parameters in table 1 should include the pathological stage.4. The results showed that PDR was a risk factor of OS and DFS. Was it an independent riskfactor? Multivariate survival anaysis should be performed to clarify this issue.5. There are a few grammar errors in the manuscript.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being publishedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
Reviewer’ s report
Title: Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular
carcinoma
Version: 1Date: 09 Jun 2020
Reviewer's report:
The authors of this study evaluated the peritumoral ductular reaction (PDR) in intrahepatic non-
mucing-producing cholangiocellular carcinoma and furthur investigated its correlations withScheuer scores in peritumor and normal liver tissues, proliferation activity of choloangiocytes,microenvironments, and prognosis. The results may help to understand the clinical significance ofPDR in cholangiocellular carcinoma. I have some comments as follows:1. The Abstract, especially the Results section, is too simple to cover the primary findings of thestudy. In the Results section, patients with significant PDR demonstrated a significantly worseprognosis but the authors did not mention which group of patients were compared to.2. Laboratory data, such as serum levels of albumin etc. were collected, but the correlationsbetween those data and PDR were not described.3. The clinicopathological parameters in table 1 should include the pathological stage.4. The results showed that PDR was a risk factor of OS and DFS. Was it an independent riskfactor? Multivariate survival anaysis should be performed to clarify this issue.5. There are a few grammar errors in the manuscript.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being publishedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
Please review this paper.
user
Reviewer’ s report
Title: Peritumoral ductular reaction can be a prognostic factor for intrahepatic cholangiocellular
carcinoma
Version: 1Date: 09 Jun 2020
Reviewer's report:
The authors of this study evaluated the peritumoral ductular reaction (PDR) in intrahepatic non-
mucing-producing cholangiocellular carcinoma and furthur investigated its correlations withScheuer scores in peritumor and normal liver tissues, proliferation activity of choloangiocytes,microenvironments, and prognosis. The results may help to understand the clinical significance ofPDR in cholangiocellular carcinoma. I have some comments as follows:1. The Abstract, especially the Results section, is too simple to cover the primary findings of thestudy. In the Results section, patients with significant PDR demonstrated a significantly worseprognosis but the authors did not mention which group of patients were compared to.2. Laboratory data, such as serum levels of albumin etc. were collected, but the correlationsbetween those data and PDR were not described.3. The clinicopathological parameters in table 1 should include the pathological stage.4. The results showed that PDR was a risk factor of OS and DFS. Was it an independent riskfactor? Multivariate survival anaysis should be performed to clarify this issue.5. There are a few grammar errors in the manuscript.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being publishedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
assistant