Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 20 Oct 2024
Reviewer's report:
Thank you for inviting me to review the manuscript. I have the following comments.
1. Line 125  I have a concern regarding this study. The authors mention that participants in
the UK Biobank underwent various surveys at baseline, but I'm curious why nearly half of the
individuals are missing lifestyle data. Does this have any impact on the evaluation of the results?
2. Line 133  In the section on healthy lifestyle components, the descriptions of diet and
physical activity are overly simplistic. For instance, regarding diet, it is important to specify the
method used to collect dietary data. Was it through 24-hour dietary recalls or a food frequency
questionnaire? What are the validity and reliability of this method? Were individuals with
abnormal energy intake taken into account? For physical activity, what questionnaire was used
for assessment, and what are its validity and reliability? Alternatively, was physical activity
assessed using a wearable device?
3. Line 156  In the definition of prediabetes, it is important to describe the sample collection and
the relevant processes and methods used for testing.
4. Line 167  What does the Townsend Deprivation Index represent?
5. What is the method for calculating the P value in Table 1?
6. The authors classified the cumulative Healthy Lifestyle Score into "favorable,"
"intermediate," and "unfavorable." Why, then, did they apply a similar grouping for individual
Healthy Lifestyle components in Table 2, and what criteria were used for this classification?
Additionally, why are there only "favorable" and "unfavorable" categories? The authors should
clearly describe this before the analysis.
Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 20 Oct 2024
Reviewer's report:
Thank you for inviting me to review the manuscript. I have the following comments.
1. Line 125  I have a concern regarding this study. The authors mention that participants in
the UK Biobank underwent various surveys at baseline, but I'm curious why nearly half of the
individuals are missing lifestyle data. Does this have any impact on the evaluation of the results?
2. Line 133  In the section on healthy lifestyle components, the descriptions of diet and
physical activity are overly simplistic. For instance, regarding diet, it is important to specify the
method used to collect dietary data. Was it through 24-hour dietary recalls or a food frequency
questionnaire? What are the validity and reliability of this method? Were individuals with
abnormal energy intake taken into account? For physical activity, what questionnaire was used
for assessment, and what are its validity and reliability? Alternatively, was physical activity
assessed using a wearable device?
3. Line 156  In the definition of prediabetes, it is important to describe the sample collection and
the relevant processes and methods used for testing.
4. Line 167  What does the Townsend Deprivation Index represent?
5. What is the method for calculating the P value in Table 1?
6. The authors classified the cumulative Healthy Lifestyle Score into "favorable,"
"intermediate," and "unfavorable." Why, then, did they apply a similar grouping for individual
Healthy Lifestyle components in Table 2, and what criteria were used for this classification?
Additionally, why are there only "favorable" and "unfavorable" categories? The authors should
clearly describe this before the analysis.
Please review this paper.
user
Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 20 Oct 2024
Reviewer's report:
Thank you for inviting me to review the manuscript. I have the following comments.
1. Line 125  I have a concern regarding this study. The authors mention that participants in
the UK Biobank underwent various surveys at baseline, but I'm curious why nearly half of the
individuals are missing lifestyle data. Does this have any impact on the evaluation of the results?
2. Line 133  In the section on healthy lifestyle components, the descriptions of diet and
physical activity are overly simplistic. For instance, regarding diet, it is important to specify the
method used to collect dietary data. Was it through 24-hour dietary recalls or a food frequency
questionnaire? What are the validity and reliability of this method? Were individuals with
abnormal energy intake taken into account? For physical activity, what questionnaire was used
for assessment, and what are its validity and reliability? Alternatively, was physical activity
assessed using a wearable device?
3. Line 156  In the definition of prediabetes, it is important to describe the sample collection and
the relevant processes and methods used for testing.
4. Line 167  What does the Townsend Deprivation Index represent?
5. What is the method for calculating the P value in Table 1?
6. The authors classified the cumulative Healthy Lifestyle Score into "favorable,"
"intermediate," and "unfavorable." Why, then, did they apply a similar grouping for individual
Healthy Lifestyle components in Table 2, and what criteria were used for this classification?
Additionally, why are there only "favorable" and "unfavorable" categories? The authors should
clearly describe this before the analysis.
assistant