Reviewer ’s report  
 
Title: Case Report of Cryptogenic Multifocal Ulcerous Sten osing Enteritis (CMUSE): A Rare 
Disease May Contribute to Endoscopy -Capsule Retention in the Sm all Intestine  
 
Version: 0 Date: 28 Feb 2019  
 
Reviewer: Wei-Chen Tai  
 
Reviewer's report:  
 
This article is a case report about capsule retention in Cryptogenic Multif ocal Ulcerous 
Stenosing Enteritis (CMUSE) patients. This is a rare small bowel disease and difficult to 
diagnosis. But it is important to distinguish from CMUSE to Crohn's disease and intestinal TB 
due to the same presentation of multiple small intestine u lcers and strictures. I have some 
comments about this article.  
 
 
1. Did the patient ever receive MR enterography(MRE) before capsule endoscopy exam? 
Because the MRE has better diagnostic rate in small bowel stricture/narrowing and can 
differentiate from acut e and chronic inflammation related intestine stricture.  
 
 
2. Patency capsule is suggested to identify patients who are at a higher risk for capsule 
retention in the video -capsule study.  
 
 
3. ACT is not a common abbreviation for abdominal computed tomography, you  may use 
abdominal CT instead of ACT.  
 
 
 
Are the methods  appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in a ny way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or  in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the  content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interest s' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
Reviewer ’s report  
 
Title: Case Report of Cryptogenic Multifocal Ulcerous Sten osing Enteritis (CMUSE): A Rare 
Disease May Contribute to Endoscopy -Capsule Retention in the Sm all Intestine  
 
Version: 0 Date: 28 Feb 2019  
 
Reviewer: Wei-Chen Tai  
 
Reviewer's report:  
 
This article is a case report about capsule retention in Cryptogenic Multif ocal Ulcerous 
Stenosing Enteritis (CMUSE) patients. This is a rare small bowel disease and difficult to 
diagnosis. But it is important to distinguish from CMUSE to Crohn's disease and intestinal TB 
due to the same presentation of multiple small intestine u lcers and strictures. I have some 
comments about this article.  
 
 
1. Did the patient ever receive MR enterography(MRE) before capsule endoscopy exam? 
Because the MRE has better diagnostic rate in small bowel stricture/narrowing and can 
differentiate from acut e and chronic inflammation related intestine stricture.  
 
 
2. Patency capsule is suggested to identify patients who are at a higher risk for capsule 
retention in the video -capsule study.  
 
 
3. ACT is not a common abbreviation for abdominal computed tomography, you  may use 
abdominal CT instead of ACT.  
 
 
 
Are the methods  appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in a ny way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or  in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the  content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interest s' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
Please review this paper.
user
Reviewer ’s report  
 
Title: Case Report of Cryptogenic Multifocal Ulcerous Sten osing Enteritis (CMUSE): A Rare 
Disease May Contribute to Endoscopy -Capsule Retention in the Sm all Intestine  
 
Version: 0 Date: 28 Feb 2019  
 
Reviewer: Wei-Chen Tai  
 
Reviewer's report:  
 
This article is a case report about capsule retention in Cryptogenic Multif ocal Ulcerous 
Stenosing Enteritis (CMUSE) patients. This is a rare small bowel disease and difficult to 
diagnosis. But it is important to distinguish from CMUSE to Crohn's disease and intestinal TB 
due to the same presentation of multiple small intestine u lcers and strictures. I have some 
comments about this article.  
 
 
1. Did the patient ever receive MR enterography(MRE) before capsule endoscopy exam? 
Because the MRE has better diagnostic rate in small bowel stricture/narrowing and can 
differentiate from acut e and chronic inflammation related intestine stricture.  
 
 
2. Patency capsule is suggested to identify patients who are at a higher risk for capsule 
retention in the video -capsule study.  
 
 
3. ACT is not a common abbreviation for abdominal computed tomography, you  may use 
abdominal CT instead of ACT.  
 
 
 
Are the methods  appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in a ny way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or  in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the  content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interest s' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
assistant