Title: Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA
study
Version: 1 Date: 16 May 2021
Reviewer:  Vik Meadows
Reviewer's report:
The authors present interesting evidence to metabolic factors that influence AFLD development.
This manuscript will help advance understanding of ALD in the authors geographic region and
population included in this manuscript.
1. The data from this manuscript is acquired from a cohort of healthy individuals who consume
at least 420g EtOH/week. This manuscript would benefit from inclusion and data analysis
comparing metabolic parameters used in this study including hepatic steatosis between >420g/
week to <420g/week and 0g/week (if there are individuals who meet these two criters- otherwise
<420g/week would suffice).
2. The authors finding that "The volume of habitual alcohol consumption at baseline does not
predict incident AFLD." should be compared to other retrospective studies. This is interesting
and important for the advancement of ALD studies so it should be emphasized and expanded
upon in the discussion. Similarly, if there are contradicting studies those should be addressed
and differences between the two studies highlighted.
3. The statistical analysis of the data acquired in this manuscript is unclear and should be
rewritten to allow for reader understanding, as in continuous and categorical variables should
be clearly defined in the methods.
4. Additionally, authors may consider changing data presentation from persons-year to persons
per year for clarity.
Title: Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA
study
Version: 1 Date: 16 May 2021
Reviewer:  Vik Meadows
Reviewer's report:
The authors present interesting evidence to metabolic factors that influence AFLD development.
This manuscript will help advance understanding of ALD in the authors geographic region and
population included in this manuscript.
1. The data from this manuscript is acquired from a cohort of healthy individuals who consume
at least 420g EtOH/week. This manuscript would benefit from inclusion and data analysis
comparing metabolic parameters used in this study including hepatic steatosis between >420g/
week to <420g/week and 0g/week (if there are individuals who meet these two criters- otherwise
<420g/week would suffice).
2. The authors finding that "The volume of habitual alcohol consumption at baseline does not
predict incident AFLD." should be compared to other retrospective studies. This is interesting
and important for the advancement of ALD studies so it should be emphasized and expanded
upon in the discussion. Similarly, if there are contradicting studies those should be addressed
and differences between the two studies highlighted.
3. The statistical analysis of the data acquired in this manuscript is unclear and should be
rewritten to allow for reader understanding, as in continuous and categorical variables should
be clearly defined in the methods.
4. Additionally, authors may consider changing data presentation from persons-year to persons
per year for clarity.
Please review this paper.
user
Title: Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA
study
Version: 1 Date: 16 May 2021
Reviewer:  Vik Meadows
Reviewer's report:
The authors present interesting evidence to metabolic factors that influence AFLD development.
This manuscript will help advance understanding of ALD in the authors geographic region and
population included in this manuscript.
1. The data from this manuscript is acquired from a cohort of healthy individuals who consume
at least 420g EtOH/week. This manuscript would benefit from inclusion and data analysis
comparing metabolic parameters used in this study including hepatic steatosis between >420g/
week to <420g/week and 0g/week (if there are individuals who meet these two criters- otherwise
<420g/week would suffice).
2. The authors finding that "The volume of habitual alcohol consumption at baseline does not
predict incident AFLD." should be compared to other retrospective studies. This is interesting
and important for the advancement of ALD studies so it should be emphasized and expanded
upon in the discussion. Similarly, if there are contradicting studies those should be addressed
and differences between the two studies highlighted.
3. The statistical analysis of the data acquired in this manuscript is unclear and should be
rewritten to allow for reader understanding, as in continuous and categorical variables should
be clearly defined in the methods.
4. Additionally, authors may consider changing data presentation from persons-year to persons
per year for clarity.
assistant