Title: Lifestyle-based nomogram for identifying the Chaoshan inhabitants of China at high risk
of Helicobacter pylori infection
Version: 0 Date: 05 Jul 2023
Reviewer's report:
Comment to the authors:
In this manuscript, Lin et al. evaluated the risk factor for Helicobacter pylori (HP) infection
and designed a lifestyle-based monogram for predicting HP infection. This manuscript might
contain some important findings. However, multiple concerns remain as below:
Major comments:
1. Given HP infection is typically established during childhood, it becomes challenging to
evaluate the impact of adult lifestyle on it, potentially raising concerns about indirect effects.
2. It's unclear whether this nomogram is superior to established HP testing methods, such as HP-
antibody tests, for predicting HP infection. While the authors discuss the financial implications
of HP testing itself, they don’t address the total cost of HP-associated disease which escalates
dramatically in the event of false negatives produced by this nomogram.
3. Given the potential complexity of predicting HP infection based on lifestyle, the authors
should conduct multiple validation tests for evaluating this nomogram.
Title: Lifestyle-based nomogram for identifying the Chaoshan inhabitants of China at high risk
of Helicobacter pylori infection
Version: 0 Date: 05 Jul 2023
Reviewer's report:
Comment to the authors:
In this manuscript, Lin et al. evaluated the risk factor for Helicobacter pylori (HP) infection
and designed a lifestyle-based monogram for predicting HP infection. This manuscript might
contain some important findings. However, multiple concerns remain as below:
Major comments:
1. Given HP infection is typically established during childhood, it becomes challenging to
evaluate the impact of adult lifestyle on it, potentially raising concerns about indirect effects.
2. It's unclear whether this nomogram is superior to established HP testing methods, such as HP-
antibody tests, for predicting HP infection. While the authors discuss the financial implications
of HP testing itself, they don’t address the total cost of HP-associated disease which escalates
dramatically in the event of false negatives produced by this nomogram.
3. Given the potential complexity of predicting HP infection based on lifestyle, the authors
should conduct multiple validation tests for evaluating this nomogram.
Please review this paper.
user
Title: Lifestyle-based nomogram for identifying the Chaoshan inhabitants of China at high risk
of Helicobacter pylori infection
Version: 0 Date: 05 Jul 2023
Reviewer's report:
Comment to the authors:
In this manuscript, Lin et al. evaluated the risk factor for Helicobacter pylori (HP) infection
and designed a lifestyle-based monogram for predicting HP infection. This manuscript might
contain some important findings. However, multiple concerns remain as below:
Major comments:
1. Given HP infection is typically established during childhood, it becomes challenging to
evaluate the impact of adult lifestyle on it, potentially raising concerns about indirect effects.
2. It's unclear whether this nomogram is superior to established HP testing methods, such as HP-
antibody tests, for predicting HP infection. While the authors discuss the financial implications
of HP testing itself, they don’t address the total cost of HP-associated disease which escalates
dramatically in the event of false negatives produced by this nomogram.
3. Given the potential complexity of predicting HP infection based on lifestyle, the authors
should conduct multiple validation tests for evaluating this nomogram.
assistant