Title: Surface Area Outcomes in EUS-Guided Liver Biopsy: A Comparative Study of Franseen
and Fork-tip Needles
Version: 4 Date: 01 Mar 2025
Reviewer's report:
1. In reference 19, the original MOSE study used MVC #4 mm as a criterion for specimen
adequacy. Did your study apply the same cut-off criteria?
2. Your study presents conflicting results compared to Nieto et al. (Ref. 23), possibly due to
differences in assessment methods (TSL vs. WSI). However, since total specimen length should
positively correlate with total tissue volume, would the conflict persist if your specimens were
measured using TSL? If discrepancies remain, please explain the possible reasons.
3. According to Table 3 and Figure 3, the median total hepatic tissue area and the maximum
hepatic tissue area per pass were different. However, in table 4, the unadjusted odds ratios (95%
CI) for sex, BMI, fibrotic stage, and MASLD were identical for both the total hepatic tissue area
and the maximum hepatic tissue area per pass. Please confirm the results.
Title: Surface Area Outcomes in EUS-Guided Liver Biopsy: A Comparative Study of Franseen
and Fork-tip Needles
Version: 4 Date: 01 Mar 2025
Reviewer's report:
1. In reference 19, the original MOSE study used MVC #4 mm as a criterion for specimen
adequacy. Did your study apply the same cut-off criteria?
2. Your study presents conflicting results compared to Nieto et al. (Ref. 23), possibly due to
differences in assessment methods (TSL vs. WSI). However, since total specimen length should
positively correlate with total tissue volume, would the conflict persist if your specimens were
measured using TSL? If discrepancies remain, please explain the possible reasons.
3. According to Table 3 and Figure 3, the median total hepatic tissue area and the maximum
hepatic tissue area per pass were different. However, in table 4, the unadjusted odds ratios (95%
CI) for sex, BMI, fibrotic stage, and MASLD were identical for both the total hepatic tissue area
and the maximum hepatic tissue area per pass. Please confirm the results.
Please review this paper.
user
Title: Surface Area Outcomes in EUS-Guided Liver Biopsy: A Comparative Study of Franseen
and Fork-tip Needles
Version: 4 Date: 01 Mar 2025
Reviewer's report:
1. In reference 19, the original MOSE study used MVC #4 mm as a criterion for specimen
adequacy. Did your study apply the same cut-off criteria?
2. Your study presents conflicting results compared to Nieto et al. (Ref. 23), possibly due to
differences in assessment methods (TSL vs. WSI). However, since total specimen length should
positively correlate with total tissue volume, would the conflict persist if your specimens were
measured using TSL? If discrepancies remain, please explain the possible reasons.
3. According to Table 3 and Figure 3, the median total hepatic tissue area and the maximum
hepatic tissue area per pass were different. However, in table 4, the unadjusted odds ratios (95%
CI) for sex, BMI, fibrotic stage, and MASLD were identical for both the total hepatic tissue area
and the maximum hepatic tissue area per pass. Please confirm the results.
assistant