Title: Prevalence of frailty among patients with inflammatory bowel disease and its association
with clinical outcomes: a systematic review and meta-analysis.
Version: 1 Date: 18 Aug 2022
Reviewer:  Suprabhat Giri
Reviewer's report:
ABSTRACT
-The sentence “Two researchers and then data independently then checked it for conformance.”
Seems incorrect. Please check.
INTRODUCTION
-The sentence “Adults at any age may occur frailty, but frailty occurs more often in the elderly”
needs modification.
METHODS
-Outcomes of interest need to be defined
RESULTS
-Table 2 can be moved to supplementary material
-The study by Qian et al. and Singh et al. used HR, the study by Bharati et al. and Wolf et al.
used OR and Fayes et al. used RR for effect size. Combining three different measures of effect
size is statistically incorrect.
-Fayes et al. considered 30-days readmission while Qian et al. analyzed 6-months readmission.
Hence, combining data of two different time frames is incorrect.
-Try reducing the sections of sensitivity analysis, publication bias and meta-regression.
DISCUSSION
-The sentence “About 18.6% of IBD patients have frailty, a high prevalence of frailty in the
general population.” needs modification.
-The sentence “We know that inflammatory bowel disease is an inflammatory disease.” needs
modification.
-Due to difference in the measures of effect size and difference in duration, meta-analysis should
not be performed for the outcomes. A systematic review would be apt for that.
-The authors should discuss how are their findings different from this systematic review,
“Katherine Bedard, Naheed Rajabali, Puneeta Tandon, Juan G. Abraldes, Farhad Peerani,
Association Between Frailty or Sarcopenia and Adverse Outcomes in Inflammatory Bowel
Disease: A Systematic Review, Gastro Hep Advances, Volume 1, Issue 2, 2022, Pages 241-250.”
-Apart the above corrections, the manuscript can benefit from English editing as there are
multiple grammatical errors.
Title: Prevalence of frailty among patients with inflammatory bowel disease and its association
with clinical outcomes: a systematic review and meta-analysis.
Version: 1 Date: 18 Aug 2022
Reviewer:  Suprabhat Giri
Reviewer's report:
ABSTRACT
-The sentence “Two researchers and then data independently then checked it for conformance.”
Seems incorrect. Please check.
INTRODUCTION
-The sentence “Adults at any age may occur frailty, but frailty occurs more often in the elderly”
needs modification.
METHODS
-Outcomes of interest need to be defined
RESULTS
-Table 2 can be moved to supplementary material
-The study by Qian et al. and Singh et al. used HR, the study by Bharati et al. and Wolf et al.
used OR and Fayes et al. used RR for effect size. Combining three different measures of effect
size is statistically incorrect.
-Fayes et al. considered 30-days readmission while Qian et al. analyzed 6-months readmission.
Hence, combining data of two different time frames is incorrect.
-Try reducing the sections of sensitivity analysis, publication bias and meta-regression.
DISCUSSION
-The sentence “About 18.6% of IBD patients have frailty, a high prevalence of frailty in the
general population.” needs modification.
-The sentence “We know that inflammatory bowel disease is an inflammatory disease.” needs
modification.
-Due to difference in the measures of effect size and difference in duration, meta-analysis should
not be performed for the outcomes. A systematic review would be apt for that.
-The authors should discuss how are their findings different from this systematic review,
“Katherine Bedard, Naheed Rajabali, Puneeta Tandon, Juan G. Abraldes, Farhad Peerani,
Association Between Frailty or Sarcopenia and Adverse Outcomes in Inflammatory Bowel
Disease: A Systematic Review, Gastro Hep Advances, Volume 1, Issue 2, 2022, Pages 241-250.”
-Apart the above corrections, the manuscript can benefit from English editing as there are
multiple grammatical errors.
Please review this paper.
user
Title: Prevalence of frailty among patients with inflammatory bowel disease and its association
with clinical outcomes: a systematic review and meta-analysis.
Version: 1 Date: 18 Aug 2022
Reviewer:  Suprabhat Giri
Reviewer's report:
ABSTRACT
-The sentence “Two researchers and then data independently then checked it for conformance.”
Seems incorrect. Please check.
INTRODUCTION
-The sentence “Adults at any age may occur frailty, but frailty occurs more often in the elderly”
needs modification.
METHODS
-Outcomes of interest need to be defined
RESULTS
-Table 2 can be moved to supplementary material
-The study by Qian et al. and Singh et al. used HR, the study by Bharati et al. and Wolf et al.
used OR and Fayes et al. used RR for effect size. Combining three different measures of effect
size is statistically incorrect.
-Fayes et al. considered 30-days readmission while Qian et al. analyzed 6-months readmission.
Hence, combining data of two different time frames is incorrect.
-Try reducing the sections of sensitivity analysis, publication bias and meta-regression.
DISCUSSION
-The sentence “About 18.6% of IBD patients have frailty, a high prevalence of frailty in the
general population.” needs modification.
-The sentence “We know that inflammatory bowel disease is an inflammatory disease.” needs
modification.
-Due to difference in the measures of effect size and difference in duration, meta-analysis should
not be performed for the outcomes. A systematic review would be apt for that.
-The authors should discuss how are their findings different from this systematic review,
“Katherine Bedard, Naheed Rajabali, Puneeta Tandon, Juan G. Abraldes, Farhad Peerani,
Association Between Frailty or Sarcopenia and Adverse Outcomes in Inflammatory Bowel
Disease: A Systematic Review, Gastro Hep Advances, Volume 1, Issue 2, 2022, Pages 241-250.”
-Apart the above corrections, the manuscript can benefit from English editing as there are
multiple grammatical errors.
assistant