Title: Chimeric antigen receptor-T cells targeting epithelial cell adhesion molecule antigens are
effective in the treatment of colorectal cancer
Version: 4 Date: 07 Apr 2024
Reviewer's report:
Thanks for considering the comments. I am satisfied with the revision; however, minor
corrections should be considered before acceptation for publication.
1. In abstract, methods: Change interference for interferon.
2. Please specify if the tumor cells lines purchased expressed Epcam or this antigen was added.
3. Treatment groups doesn’t match in section 2.7, 3.3, 3.5 and also in the discussion.
4. In section 3.4  in HeLa cells group. All HeLa cells were EpCAM negative? If there were also
HeLa EpCAM positive cells, did they respond to treatment?
If these questions are addressed, I would happily accept this manuscript for publication.
Title: Chimeric antigen receptor-T cells targeting epithelial cell adhesion molecule antigens are
effective in the treatment of colorectal cancer
Version: 4 Date: 07 Apr 2024
Reviewer's report:
Thanks for considering the comments. I am satisfied with the revision; however, minor
corrections should be considered before acceptation for publication.
1. In abstract, methods: Change interference for interferon.
2. Please specify if the tumor cells lines purchased expressed Epcam or this antigen was added.
3. Treatment groups doesn’t match in section 2.7, 3.3, 3.5 and also in the discussion.
4. In section 3.4  in HeLa cells group. All HeLa cells were EpCAM negative? If there were also
HeLa EpCAM positive cells, did they respond to treatment?
If these questions are addressed, I would happily accept this manuscript for publication.
Please review this paper.
user
Title: Chimeric antigen receptor-T cells targeting epithelial cell adhesion molecule antigens are
effective in the treatment of colorectal cancer
Version: 4 Date: 07 Apr 2024
Reviewer's report:
Thanks for considering the comments. I am satisfied with the revision; however, minor
corrections should be considered before acceptation for publication.
1. In abstract, methods: Change interference for interferon.
2. Please specify if the tumor cells lines purchased expressed Epcam or this antigen was added.
3. Treatment groups doesn’t match in section 2.7, 3.3, 3.5 and also in the discussion.
4. In section 3.4  in HeLa cells group. All HeLa cells were EpCAM negative? If there were also
HeLa EpCAM positive cells, did they respond to treatment?
If these questions are addressed, I would happily accept this manuscript for publication.
assistant