Title: Development and Validation of a New Algorithm Model for Differential Diagnosis
Between Crohn's Disease and Intestinal Tuberculosis: A Combination of Laboratory, Imaging
and Endoscopic Characteristics
Version: 1 Date: 18 Mar 2021
Reviewer:  José María Paredes
Reviewer's report:
Interesting and practical work by Ly Y et al. However, several considerations are necessary for
it to be accepted for publication.
Major considerations:
a) It should explain how the endoscopic and radiological variables have been selected. For
example: why do they consider 4 or more segments affected?
b) A better description of the locations affected by both diseases should be made in the endoscopy
and in the imaging techniques.
c) The results must be reviewed. If p <0.05 is considered significant, there is an error in the
comparison of the pathological variables
Minor Considerations:
a) The ITB and CD groups must be maintained throughout the text and the tables. Avoid calling
them differently (Groups 1 and 2).
b) At the beginning of the work, it should be defined that T-SPOT is a trademark for the detection
of the release of interferon Gamma. Remove it from the discussion.
c) The flow of patients and their selection should be explained in detail. Personally, I do not
understand where this sentence comes from: "One hundred and sixty-eight and forty-four cases
were allocated to the training cohort and validation cohort, respectively".
d) Table 6 should be revised and should define the acronyms.
Title: Development and Validation of a New Algorithm Model for Differential Diagnosis
Between Crohn's Disease and Intestinal Tuberculosis: A Combination of Laboratory, Imaging
and Endoscopic Characteristics
Version: 1 Date: 18 Mar 2021
Reviewer:  José María Paredes
Reviewer's report:
Interesting and practical work by Ly Y et al. However, several considerations are necessary for
it to be accepted for publication.
Major considerations:
a) It should explain how the endoscopic and radiological variables have been selected. For
example: why do they consider 4 or more segments affected?
b) A better description of the locations affected by both diseases should be made in the endoscopy
and in the imaging techniques.
c) The results must be reviewed. If p <0.05 is considered significant, there is an error in the
comparison of the pathological variables
Minor Considerations:
a) The ITB and CD groups must be maintained throughout the text and the tables. Avoid calling
them differently (Groups 1 and 2).
b) At the beginning of the work, it should be defined that T-SPOT is a trademark for the detection
of the release of interferon Gamma. Remove it from the discussion.
c) The flow of patients and their selection should be explained in detail. Personally, I do not
understand where this sentence comes from: "One hundred and sixty-eight and forty-four cases
were allocated to the training cohort and validation cohort, respectively".
d) Table 6 should be revised and should define the acronyms.
Please review this paper.
user
Title: Development and Validation of a New Algorithm Model for Differential Diagnosis
Between Crohn's Disease and Intestinal Tuberculosis: A Combination of Laboratory, Imaging
and Endoscopic Characteristics
Version: 1 Date: 18 Mar 2021
Reviewer:  José María Paredes
Reviewer's report:
Interesting and practical work by Ly Y et al. However, several considerations are necessary for
it to be accepted for publication.
Major considerations:
a) It should explain how the endoscopic and radiological variables have been selected. For
example: why do they consider 4 or more segments affected?
b) A better description of the locations affected by both diseases should be made in the endoscopy
and in the imaging techniques.
c) The results must be reviewed. If p <0.05 is considered significant, there is an error in the
comparison of the pathological variables
Minor Considerations:
a) The ITB and CD groups must be maintained throughout the text and the tables. Avoid calling
them differently (Groups 1 and 2).
b) At the beginning of the work, it should be defined that T-SPOT is a trademark for the detection
of the release of interferon Gamma. Remove it from the discussion.
c) The flow of patients and their selection should be explained in detail. Personally, I do not
understand where this sentence comes from: "One hundred and sixty-eight and forty-four cases
were allocated to the training cohort and validation cohort, respectively".
d) Table 6 should be revised and should define the acronyms.
assistant