Title: Relationship Between Gastric Mucosal Atrophy, Cystic Dilatation, and Histopathological
Characteristics
Version: 0 Date: 01 Oct 2024
Reviewer's report:
In this study, the authors investigated the relationship between cystic dilatation of the
gastric mucosa and mucosal atrophy in a good number of endoscopic biopsy samples by
histopathological and immunohistochemical evaluation.
They suggested that this condition originates from gastric mucosal atrophy which may progress
into either simple cystic dilatation or into compound cystic dilatation, both of them having
distinct histological features and risk of carcinogenesis.
Overall the manuscript is well structured and written. The results are clearly presented and the
discussion is comprehensive.
Considering the effect of H. pylori infection on atrophic gastritis and gastric cancer development,
I would like to see the incidence of H. pylori in this sample of specimens and its association
with the findings of the study. However, I understand that this was not included in the planning
of the study.
Some minor points: It would be useful for the readers to give the magnifications used in Figs
2-4. Similarly, the use of arrows to delineate the points of interest in these figures would add
clarity for readers not familiar with histopathology and immunestaining images.
Title: Relationship Between Gastric Mucosal Atrophy, Cystic Dilatation, and Histopathological
Characteristics
Version: 0 Date: 01 Oct 2024
Reviewer's report:
In this study, the authors investigated the relationship between cystic dilatation of the
gastric mucosa and mucosal atrophy in a good number of endoscopic biopsy samples by
histopathological and immunohistochemical evaluation.
They suggested that this condition originates from gastric mucosal atrophy which may progress
into either simple cystic dilatation or into compound cystic dilatation, both of them having
distinct histological features and risk of carcinogenesis.
Overall the manuscript is well structured and written. The results are clearly presented and the
discussion is comprehensive.
Considering the effect of H. pylori infection on atrophic gastritis and gastric cancer development,
I would like to see the incidence of H. pylori in this sample of specimens and its association
with the findings of the study. However, I understand that this was not included in the planning
of the study.
Some minor points: It would be useful for the readers to give the magnifications used in Figs
2-4. Similarly, the use of arrows to delineate the points of interest in these figures would add
clarity for readers not familiar with histopathology and immunestaining images.
Please review this paper.
user
Title: Relationship Between Gastric Mucosal Atrophy, Cystic Dilatation, and Histopathological
Characteristics
Version: 0 Date: 01 Oct 2024
Reviewer's report:
In this study, the authors investigated the relationship between cystic dilatation of the
gastric mucosa and mucosal atrophy in a good number of endoscopic biopsy samples by
histopathological and immunohistochemical evaluation.
They suggested that this condition originates from gastric mucosal atrophy which may progress
into either simple cystic dilatation or into compound cystic dilatation, both of them having
distinct histological features and risk of carcinogenesis.
Overall the manuscript is well structured and written. The results are clearly presented and the
discussion is comprehensive.
Considering the effect of H. pylori infection on atrophic gastritis and gastric cancer development,
I would like to see the incidence of H. pylori in this sample of specimens and its association
with the findings of the study. However, I understand that this was not included in the planning
of the study.
Some minor points: It would be useful for the readers to give the magnifications used in Figs
2-4. Similarly, the use of arrows to delineate the points of interest in these figures would add
clarity for readers not familiar with histopathology and immunestaining images.
assistant