Title: Prognostic significance of the Naples prognostic score in colorectal cancer patients
undergoing curative resection: A propensity score matching analysis
Version: 1 Date: 10 Feb 2023
Reviewer's report:
Thank you for allowing me to review this manuscript. For the most part, the result is clear, and
the interpretation of the data is warranted. I also think that the topic may be of interest to the
field. However, I have found some issues that will improve the manuscript.
1 Because chemotherapy or radiotherapy can affect neutrophils, neoadjuvant treatment cases
should be excluded from the analysis. Additionally, the number of these patients is minimal.
2 Propensity matching should include pT and pN instead of pStage as oncological factors. In
the current analysis, the operative times between the two groups differ even after the propensity
score. This result means that more advanced cancers were present in the HighNPS group.
3 Show the years after surgery when inflammatory markers were compared in the time-
dependent ROC curve.
4 There is no prognostic difference in DFS, which raises the question of whether NPS represents
cancer progression. Discuss this point.
Title: Prognostic significance of the Naples prognostic score in colorectal cancer patients
undergoing curative resection: A propensity score matching analysis
Version: 1 Date: 10 Feb 2023
Reviewer's report:
Thank you for allowing me to review this manuscript. For the most part, the result is clear, and
the interpretation of the data is warranted. I also think that the topic may be of interest to the
field. However, I have found some issues that will improve the manuscript.
1 Because chemotherapy or radiotherapy can affect neutrophils, neoadjuvant treatment cases
should be excluded from the analysis. Additionally, the number of these patients is minimal.
2 Propensity matching should include pT and pN instead of pStage as oncological factors. In
the current analysis, the operative times between the two groups differ even after the propensity
score. This result means that more advanced cancers were present in the HighNPS group.
3 Show the years after surgery when inflammatory markers were compared in the time-
dependent ROC curve.
4 There is no prognostic difference in DFS, which raises the question of whether NPS represents
cancer progression. Discuss this point.
Please review this paper.
user
Title: Prognostic significance of the Naples prognostic score in colorectal cancer patients
undergoing curative resection: A propensity score matching analysis
Version: 1 Date: 10 Feb 2023
Reviewer's report:
Thank you for allowing me to review this manuscript. For the most part, the result is clear, and
the interpretation of the data is warranted. I also think that the topic may be of interest to the
field. However, I have found some issues that will improve the manuscript.
1 Because chemotherapy or radiotherapy can affect neutrophils, neoadjuvant treatment cases
should be excluded from the analysis. Additionally, the number of these patients is minimal.
2 Propensity matching should include pT and pN instead of pStage as oncological factors. In
the current analysis, the operative times between the two groups differ even after the propensity
score. This result means that more advanced cancers were present in the HighNPS group.
3 Show the years after surgery when inflammatory markers were compared in the time-
dependent ROC curve.
4 There is no prognostic difference in DFS, which raises the question of whether NPS represents
cancer progression. Discuss this point.
assistant