Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 1 Date: 27 Jun 2022
Reviewer's report:
There are many limitations in this manuscript which is not suitable to be published in the current
form.
My comments are listed as follows.
1. Abbreviations must be defined upon first use, and provide the full name in both the Abstract
and the main text.
2. In Abstract, the authors did not mention the correlation results.
3. The conclusion should be concise and only summarize the most important contribution of the
research in both the Abstract and the main text.
4. In Introduction, please simplifying for readability. And focus on the relationship regrading
inflammatory and CD
5. In statistical analysis, why the authors used Student’s t-criterion test? Whether these
continuous variables were fitted the normal distribution? Otherwise, the authors should replace
by Mann-Whitney U test. Additionally, please provide a test for normal distribution.
6. why the authors used Spearman method to conduct correlation analysis?
7. Confounding factor may be in this study, the authors seemed to do not consider it, and how
to control it?
8. In Results, keeping the P value in three decimal places, for example P <0.001.
9. In Discussion, please discussed the similarities between the current results with previous
findings, and provide reasonable explanations for potential inconformity.
10. In Discussion, avoid to mention the results and use conclusion and general sentence.
11. The Conclusion should be concise and only summarize the most important contribution of
the research, please make a difference between the results and the conclusions.
Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 1 Date: 27 Jun 2022
Reviewer's report:
There are many limitations in this manuscript which is not suitable to be published in the current
form.
My comments are listed as follows.
1. Abbreviations must be defined upon first use, and provide the full name in both the Abstract
and the main text.
2. In Abstract, the authors did not mention the correlation results.
3. The conclusion should be concise and only summarize the most important contribution of the
research in both the Abstract and the main text.
4. In Introduction, please simplifying for readability. And focus on the relationship regrading
inflammatory and CD
5. In statistical analysis, why the authors used Student’s t-criterion test? Whether these
continuous variables were fitted the normal distribution? Otherwise, the authors should replace
by Mann-Whitney U test. Additionally, please provide a test for normal distribution.
6. why the authors used Spearman method to conduct correlation analysis?
7. Confounding factor may be in this study, the authors seemed to do not consider it, and how
to control it?
8. In Results, keeping the P value in three decimal places, for example P <0.001.
9. In Discussion, please discussed the similarities between the current results with previous
findings, and provide reasonable explanations for potential inconformity.
10. In Discussion, avoid to mention the results and use conclusion and general sentence.
11. The Conclusion should be concise and only summarize the most important contribution of
the research, please make a difference between the results and the conclusions.
Please review this paper.
user
Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 1 Date: 27 Jun 2022
Reviewer's report:
There are many limitations in this manuscript which is not suitable to be published in the current
form.
My comments are listed as follows.
1. Abbreviations must be defined upon first use, and provide the full name in both the Abstract
and the main text.
2. In Abstract, the authors did not mention the correlation results.
3. The conclusion should be concise and only summarize the most important contribution of the
research in both the Abstract and the main text.
4. In Introduction, please simplifying for readability. And focus on the relationship regrading
inflammatory and CD
5. In statistical analysis, why the authors used Student’s t-criterion test? Whether these
continuous variables were fitted the normal distribution? Otherwise, the authors should replace
by Mann-Whitney U test. Additionally, please provide a test for normal distribution.
6. why the authors used Spearman method to conduct correlation analysis?
7. Confounding factor may be in this study, the authors seemed to do not consider it, and how
to control it?
8. In Results, keeping the P value in three decimal places, for example P <0.001.
9. In Discussion, please discussed the similarities between the current results with previous
findings, and provide reasonable explanations for potential inconformity.
10. In Discussion, avoid to mention the results and use conclusion and general sentence.
11. The Conclusion should be concise and only summarize the most important contribution of
the research, please make a difference between the results and the conclusions.
assistant