Title: Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality
in adults with MASLD
Version: 2 Date: 05 Feb 2025
Reviewer's report:
The manuscript titled "The predictive role of neutrophil percentage-to-albumin ratio, neutrophil-
to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with
MASLD" presents an interesting exploration into the relationship between various inflammatory
markers and mortality outcomes in patients with MASLD
While the study provides valuable insights, I find that its novelty and contribution to the current
body of literature are limited due to substantial overlap with another recently published work:
Dong, Kaixuan et al. “Predictive role of neutrophil percentage-to-albumin ratio, neutrophil-
to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with
MASLD” (Scientific Reports, 2024).
The current manuscript closely mirrors the findings of the study by Dong et al., which also
explores the predictive role of NLR in MASLD patients. The research methods, including the use
of NHANES data, multivariate Cox regression, and restricted cubic spline analysis, are highly
similar. Furthermore, both studies identify NLR as an important marker for predicting all-cause
and cardiovascular mortality in MASLD patients, thus raising concerns regarding the novelty
of the study.
While the study incorporates additional markers such as NPAR and SII, the central focus remains
on NLR, a marker already well-established in the field, especially in MASLD. The comparison
between these markers does not seem to offer new insights beyond what has already been
published. For example, the nonlinear relationship between NLR and mortality outcomes is
already well-documented in the existing literature, including the previously mentioned study.
To elevate this manuscript’s contribution to the field, the authors may want to consider adding
more unique angles, such as exploring the molecular mechanisms behind these inflammatory
markers in MASLD or investigating a more diverse set of patient populations (e.g., ethnic
differences or comorbidities).
Given the high level of similarity between this manuscript and the existing literature, especially
the work by Dong et al., the study lacks sufficient novelty to merit publication in its current
form. A clearer differentiation from the previously published study or additional original insights
would be necessary for further consideration.
Title: Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality
in adults with MASLD
Version: 2 Date: 05 Feb 2025
Reviewer's report:
The manuscript titled "The predictive role of neutrophil percentage-to-albumin ratio, neutrophil-
to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with
MASLD" presents an interesting exploration into the relationship between various inflammatory
markers and mortality outcomes in patients with MASLD
While the study provides valuable insights, I find that its novelty and contribution to the current
body of literature are limited due to substantial overlap with another recently published work:
Dong, Kaixuan et al. “Predictive role of neutrophil percentage-to-albumin ratio, neutrophil-
to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with
MASLD” (Scientific Reports, 2024).
The current manuscript closely mirrors the findings of the study by Dong et al., which also
explores the predictive role of NLR in MASLD patients. The research methods, including the use
of NHANES data, multivariate Cox regression, and restricted cubic spline analysis, are highly
similar. Furthermore, both studies identify NLR as an important marker for predicting all-cause
and cardiovascular mortality in MASLD patients, thus raising concerns regarding the novelty
of the study.
While the study incorporates additional markers such as NPAR and SII, the central focus remains
on NLR, a marker already well-established in the field, especially in MASLD. The comparison
between these markers does not seem to offer new insights beyond what has already been
published. For example, the nonlinear relationship between NLR and mortality outcomes is
already well-documented in the existing literature, including the previously mentioned study.
To elevate this manuscript’s contribution to the field, the authors may want to consider adding
more unique angles, such as exploring the molecular mechanisms behind these inflammatory
markers in MASLD or investigating a more diverse set of patient populations (e.g., ethnic
differences or comorbidities).
Given the high level of similarity between this manuscript and the existing literature, especially
the work by Dong et al., the study lacks sufficient novelty to merit publication in its current
form. A clearer differentiation from the previously published study or additional original insights
would be necessary for further consideration.
Please review this paper.
user
Title: Prognostic impact of systemic inflammation indicators on all-cause and CVD mortality
in adults with MASLD
Version: 2 Date: 05 Feb 2025
Reviewer's report:
The manuscript titled "The predictive role of neutrophil percentage-to-albumin ratio, neutrophil-
to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with
MASLD" presents an interesting exploration into the relationship between various inflammatory
markers and mortality outcomes in patients with MASLD
While the study provides valuable insights, I find that its novelty and contribution to the current
body of literature are limited due to substantial overlap with another recently published work:
Dong, Kaixuan et al. “Predictive role of neutrophil percentage-to-albumin ratio, neutrophil-
to-lymphocyte ratio, and systemic immune-inflammation index for mortality in patients with
MASLD” (Scientific Reports, 2024).
The current manuscript closely mirrors the findings of the study by Dong et al., which also
explores the predictive role of NLR in MASLD patients. The research methods, including the use
of NHANES data, multivariate Cox regression, and restricted cubic spline analysis, are highly
similar. Furthermore, both studies identify NLR as an important marker for predicting all-cause
and cardiovascular mortality in MASLD patients, thus raising concerns regarding the novelty
of the study.
While the study incorporates additional markers such as NPAR and SII, the central focus remains
on NLR, a marker already well-established in the field, especially in MASLD. The comparison
between these markers does not seem to offer new insights beyond what has already been
published. For example, the nonlinear relationship between NLR and mortality outcomes is
already well-documented in the existing literature, including the previously mentioned study.
To elevate this manuscript’s contribution to the field, the authors may want to consider adding
more unique angles, such as exploring the molecular mechanisms behind these inflammatory
markers in MASLD or investigating a more diverse set of patient populations (e.g., ethnic
differences or comorbidities).
Given the high level of similarity between this manuscript and the existing literature, especially
the work by Dong et al., the study lacks sufficient novelty to merit publication in its current
form. A clearer differentiation from the previously published study or additional original insights
would be necessary for further consideration.
assistant