Title: Symptoms and biomarkers associated with undiagnosed celiac seropositivity
Version: 3 Date: 15 Jan 2021
Reviewer's report:
I’ve read with interest the revised version of the manuscript entitled “Symptoms and biomarkers
associated with undiagnosed celiac disease”, which aims at assessing symptoms and biomarkers
associated with undiagnosed CD and could trigger testing for this disease.
Indeed, as well reported in the introduction, CD is heavily underdiagnosed and has significant
diagnostic delay. The strong point of the study is the large sample size. However, there is
a lack of novelty with regard to its objectives, as indications for CD testing according to
symptoms and laboratory changes are well known. Also, a major limitation of the paper is
considering CD diagnosis based on serology only, which is not in accordance with current
guideline recommendation; in this respect, the title, abstract and results are currently misleading
– they should all report on positive CD-related serology and not CD diagnosis.
Title: Symptoms and biomarkers associated with undiagnosed celiac seropositivity
Version: 3 Date: 15 Jan 2021
Reviewer's report:
I’ve read with interest the revised version of the manuscript entitled “Symptoms and biomarkers
associated with undiagnosed celiac disease”, which aims at assessing symptoms and biomarkers
associated with undiagnosed CD and could trigger testing for this disease.
Indeed, as well reported in the introduction, CD is heavily underdiagnosed and has significant
diagnostic delay. The strong point of the study is the large sample size. However, there is
a lack of novelty with regard to its objectives, as indications for CD testing according to
symptoms and laboratory changes are well known. Also, a major limitation of the paper is
considering CD diagnosis based on serology only, which is not in accordance with current
guideline recommendation; in this respect, the title, abstract and results are currently misleading
– they should all report on positive CD-related serology and not CD diagnosis.
Please review this paper.
user
Title: Symptoms and biomarkers associated with undiagnosed celiac seropositivity
Version: 3 Date: 15 Jan 2021
Reviewer's report:
I’ve read with interest the revised version of the manuscript entitled “Symptoms and biomarkers
associated with undiagnosed celiac disease”, which aims at assessing symptoms and biomarkers
associated with undiagnosed CD and could trigger testing for this disease.
Indeed, as well reported in the introduction, CD is heavily underdiagnosed and has significant
diagnostic delay. The strong point of the study is the large sample size. However, there is
a lack of novelty with regard to its objectives, as indications for CD testing according to
symptoms and laboratory changes are well known. Also, a major limitation of the paper is
considering CD diagnosis based on serology only, which is not in accordance with current
guideline recommendation; in this respect, the title, abstract and results are currently misleading
– they should all report on positive CD-related serology and not CD diagnosis.
assistant