Title: Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the
development of non-alcoholic fatty liver disease: a cross-sectional study
Version: 4 Date: 05 Dec 2021
Reviewer's report:
The authors have addressed the concerns adequately.
Comments to the authors
1) In the absence of the data of direct bilirubin and indirect bilirubin of the subjects, the authors
should discuss failure as one of the limitations of the study design in terms of this study
investigated UGT1A1 that glucuronidates bilirubin.
2, The authors described the severity and the incidence of NAFLD in this study as “the risk”
of NAFLD in the title and results. However, the present study design was cross-sectional and I
think the expression of “the risk” is inaccurate.
3, It is better to check the spelling and grammar of text in the document;
"The inconsistent results of the association between circulating TB and the risk of NAFLD may
due to the diagnstic method of NAFLD and the genetic background of subjects. "
Title: Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the
development of non-alcoholic fatty liver disease: a cross-sectional study
Version: 4 Date: 05 Dec 2021
Reviewer's report:
The authors have addressed the concerns adequately.
Comments to the authors
1) In the absence of the data of direct bilirubin and indirect bilirubin of the subjects, the authors
should discuss failure as one of the limitations of the study design in terms of this study
investigated UGT1A1 that glucuronidates bilirubin.
2, The authors described the severity and the incidence of NAFLD in this study as “the risk”
of NAFLD in the title and results. However, the present study design was cross-sectional and I
think the expression of “the risk” is inaccurate.
3, It is better to check the spelling and grammar of text in the document;
"The inconsistent results of the association between circulating TB and the risk of NAFLD may
due to the diagnstic method of NAFLD and the genetic background of subjects. "
Please review this paper.
user
Title: Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the
development of non-alcoholic fatty liver disease: a cross-sectional study
Version: 4 Date: 05 Dec 2021
Reviewer's report:
The authors have addressed the concerns adequately.
Comments to the authors
1) In the absence of the data of direct bilirubin and indirect bilirubin of the subjects, the authors
should discuss failure as one of the limitations of the study design in terms of this study
investigated UGT1A1 that glucuronidates bilirubin.
2, The authors described the severity and the incidence of NAFLD in this study as “the risk”
of NAFLD in the title and results. However, the present study design was cross-sectional and I
think the expression of “the risk” is inaccurate.
3, It is better to check the spelling and grammar of text in the document;
"The inconsistent results of the association between circulating TB and the risk of NAFLD may
due to the diagnstic method of NAFLD and the genetic background of subjects. "
assistant