Reviewer's report
Title:The earliest trough concentration predicts the dose of tacrolimus required
for remission induction therapy in ulcerative colitis patients
Version:2Date:14 February 2015
Reviewer: Uri Kopylov
Reviewer's report:
Overall an interesting and useful manuscript. However the presentation of results
is confusing and unclear
Several points:
1)the outcome of trough level- was there any target time to reach it?
2)what were the observed side effects
3) please clarify the algorythm you are suggesting for tacrolimus dose
acceleration
4)should the polymorphism data and the adverse effects be incorporated in such
an algorythm?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Reviewer's report
Title:The earliest trough concentration predicts the dose of tacrolimus required
for remission induction therapy in ulcerative colitis patients
Version:2Date:14 February 2015
Reviewer: Uri Kopylov
Reviewer's report:
Overall an interesting and useful manuscript. However the presentation of results
is confusing and unclear
Several points:
1)the outcome of trough level- was there any target time to reach it?
2)what were the observed side effects
3) please clarify the algorythm you are suggesting for tacrolimus dose
acceleration
4)should the polymorphism data and the adverse effects be incorporated in such
an algorythm?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Please review this paper.
user
Reviewer's report
Title:The earliest trough concentration predicts the dose of tacrolimus required
for remission induction therapy in ulcerative colitis patients
Version:2Date:14 February 2015
Reviewer: Uri Kopylov
Reviewer's report:
Overall an interesting and useful manuscript. However the presentation of results
is confusing and unclear
Several points:
1)the outcome of trough level- was there any target time to reach it?
2)what were the observed side effects
3) please clarify the algorythm you are suggesting for tacrolimus dose
acceleration
4)should the polymorphism data and the adverse effects be incorporated in such
an algorythm?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
assistant