Title: Long term persistence and risk factors for anorectal symptoms following low anterior
resection for rectal cancer
Version: 2 Date: 01 Aug 2023
Reviewer:  Wilhelm Graf
Reviewer's report:
Thanks for the opportunity to review the manuskript describing the funktionalitet outcome after
sprinter presenning surgery for rectal cancer. My comments are listen below.
1. It is virtuella impossible to draw firm conclusions based on diagnostical and therapeutic
measures since these measures are based on a percieved clinical need in view of the individual
patient.
2. A more rewarding strategy would be a prospective protocol demanding all participants to
undergo examinations and treatment.
3. The failure to detect efficacy of BF treatment is most likely due to that treatment was given
to those with worse symptom.
4. The distance from the anal verket is important for functional outcome. The authors only
describe coloanal vs colorectal which is to crude.
5. Likewise, anastomotic dehiscence should be exactly defined.
6. The authors found that time to stora closure correlated to function. However there maybe
confounding by anastomotic complications causing a delar to closure.
7. The time for manometry varied considerably which is a clear limitation. The lack of
standradization makes results inconclusive.
8. Thee abstract contain a recommendation for sacral neuromudulation which is not bsed on the
study results.
Title: Long term persistence and risk factors for anorectal symptoms following low anterior
resection for rectal cancer
Version: 2 Date: 01 Aug 2023
Reviewer:  Wilhelm Graf
Reviewer's report:
Thanks for the opportunity to review the manuskript describing the funktionalitet outcome after
sprinter presenning surgery for rectal cancer. My comments are listen below.
1. It is virtuella impossible to draw firm conclusions based on diagnostical and therapeutic
measures since these measures are based on a percieved clinical need in view of the individual
patient.
2. A more rewarding strategy would be a prospective protocol demanding all participants to
undergo examinations and treatment.
3. The failure to detect efficacy of BF treatment is most likely due to that treatment was given
to those with worse symptom.
4. The distance from the anal verket is important for functional outcome. The authors only
describe coloanal vs colorectal which is to crude.
5. Likewise, anastomotic dehiscence should be exactly defined.
6. The authors found that time to stora closure correlated to function. However there maybe
confounding by anastomotic complications causing a delar to closure.
7. The time for manometry varied considerably which is a clear limitation. The lack of
standradization makes results inconclusive.
8. Thee abstract contain a recommendation for sacral neuromudulation which is not bsed on the
study results.
Please review this paper.
user
Title: Long term persistence and risk factors for anorectal symptoms following low anterior
resection for rectal cancer
Version: 2 Date: 01 Aug 2023
Reviewer:  Wilhelm Graf
Reviewer's report:
Thanks for the opportunity to review the manuskript describing the funktionalitet outcome after
sprinter presenning surgery for rectal cancer. My comments are listen below.
1. It is virtuella impossible to draw firm conclusions based on diagnostical and therapeutic
measures since these measures are based on a percieved clinical need in view of the individual
patient.
2. A more rewarding strategy would be a prospective protocol demanding all participants to
undergo examinations and treatment.
3. The failure to detect efficacy of BF treatment is most likely due to that treatment was given
to those with worse symptom.
4. The distance from the anal verket is important for functional outcome. The authors only
describe coloanal vs colorectal which is to crude.
5. Likewise, anastomotic dehiscence should be exactly defined.
6. The authors found that time to stora closure correlated to function. However there maybe
confounding by anastomotic complications causing a delar to closure.
7. The time for manometry varied considerably which is a clear limitation. The lack of
standradization makes results inconclusive.
8. Thee abstract contain a recommendation for sacral neuromudulation which is not bsed on the
study results.
assistant