Title: Adenocarcinoma of the esophagogastric junction: characteristics of female patients
and young adult patients based on a 12-year retrospective and prospective multicenter
clinicoepidemiological cohort study in Japan
Version: 3 Date: 30 May 2024
Reviewer:  Masayuki Watanabe
Reviewer's report:
The authors conducted a multicenter clinicoepidemiological cohort study on the characteristics
of female and young adult patients with adenocarcinoma of the EGJ. Patients without any known
associated factors, including obesity, smoking, hiatal hernia, and male, accounted for 53% of
female patients, and they had significantly more undifferentiated tumors than those with at
least one associated factor. Also, young adult patients had more undifferentiated tumors than
middle-aged and elderly patients. This manuscript may provide important clinical information
for readers. Several changes will improve the quality of this manuscript.
1. The discussion seems too long and redundant. As the essential findings of this study were the
characteristics of female and young adult patients with AEGJ, I recommend the authors make
the discussion concise by focusing only on these findings.
2. The conclusion is also redundant, as the authors repeated the same things that were said in
the discussion. Please make it concise so readers understand it better.
3. It is hard to understand the trend of the male-to-female ratio in Figure 1. A 100% component
bar chart combined with a line of total numbers is better for visualizing the trend.
4. The same things happen in Figure 3. I recommend using a 100% component bar chart to
demonstrate the trend in the age groups.
Title: Adenocarcinoma of the esophagogastric junction: characteristics of female patients
and young adult patients based on a 12-year retrospective and prospective multicenter
clinicoepidemiological cohort study in Japan
Version: 3 Date: 30 May 2024
Reviewer:  Masayuki Watanabe
Reviewer's report:
The authors conducted a multicenter clinicoepidemiological cohort study on the characteristics
of female and young adult patients with adenocarcinoma of the EGJ. Patients without any known
associated factors, including obesity, smoking, hiatal hernia, and male, accounted for 53% of
female patients, and they had significantly more undifferentiated tumors than those with at
least one associated factor. Also, young adult patients had more undifferentiated tumors than
middle-aged and elderly patients. This manuscript may provide important clinical information
for readers. Several changes will improve the quality of this manuscript.
1. The discussion seems too long and redundant. As the essential findings of this study were the
characteristics of female and young adult patients with AEGJ, I recommend the authors make
the discussion concise by focusing only on these findings.
2. The conclusion is also redundant, as the authors repeated the same things that were said in
the discussion. Please make it concise so readers understand it better.
3. It is hard to understand the trend of the male-to-female ratio in Figure 1. A 100% component
bar chart combined with a line of total numbers is better for visualizing the trend.
4. The same things happen in Figure 3. I recommend using a 100% component bar chart to
demonstrate the trend in the age groups.
Please review this paper.
user
Title: Adenocarcinoma of the esophagogastric junction: characteristics of female patients
and young adult patients based on a 12-year retrospective and prospective multicenter
clinicoepidemiological cohort study in Japan
Version: 3 Date: 30 May 2024
Reviewer:  Masayuki Watanabe
Reviewer's report:
The authors conducted a multicenter clinicoepidemiological cohort study on the characteristics
of female and young adult patients with adenocarcinoma of the EGJ. Patients without any known
associated factors, including obesity, smoking, hiatal hernia, and male, accounted for 53% of
female patients, and they had significantly more undifferentiated tumors than those with at
least one associated factor. Also, young adult patients had more undifferentiated tumors than
middle-aged and elderly patients. This manuscript may provide important clinical information
for readers. Several changes will improve the quality of this manuscript.
1. The discussion seems too long and redundant. As the essential findings of this study were the
characteristics of female and young adult patients with AEGJ, I recommend the authors make
the discussion concise by focusing only on these findings.
2. The conclusion is also redundant, as the authors repeated the same things that were said in
the discussion. Please make it concise so readers understand it better.
3. It is hard to understand the trend of the male-to-female ratio in Figure 1. A 100% component
bar chart combined with a line of total numbers is better for visualizing the trend.
4. The same things happen in Figure 3. I recommend using a 100% component bar chart to
demonstrate the trend in the age groups.
assistant