Title: Clip-and-snare method with a pre-looping technique versus conventional method in the
treatment of precancerous lesion and early gastric cancer: a retrospective study
Version: 1 Date: 14 Nov 2023
Reviewer's report:
1. CSM-PLT, firstly reported in 2014, is not completely new, and there have been many
comparisons with conventional ESD. A multicenter prospective randomized controlled study
was reported last year (Hasatani K, Yoshida N, Aoyagi H, et al. Usefulness of the clip-and-
snare method using the pre-looping technique for endoscopic submucosal dissection of gastric
neoplasia: a randomized controlled trial. Ann Gastroenterol. 2022 Jan-Feb;35(1):48-55. doi:
10.20524/aog.2021.0679.), so there appears to be a relative lack of comparative power for
current single-center retrospective study.
2. The CSM-PLT group took longer than that of the conventional ESD group in this study,
which is inconsistent with others. It seems to be because the CSM-PLT group had larger lesion
size than that of the conventional ESD group. But why the significant difference in lesion size
occurred between two groups? Would you please to give any explanation or analysis for it?
3. The resection speed in different parts of the gastric body was compared in subgroup analysis,
but statistics and analysis of lesion size in different parts were missing. It may be helpful in
explaining the above questions.
Title: Clip-and-snare method with a pre-looping technique versus conventional method in the
treatment of precancerous lesion and early gastric cancer: a retrospective study
Version: 1 Date: 14 Nov 2023
Reviewer's report:
1. CSM-PLT, firstly reported in 2014, is not completely new, and there have been many
comparisons with conventional ESD. A multicenter prospective randomized controlled study
was reported last year (Hasatani K, Yoshida N, Aoyagi H, et al. Usefulness of the clip-and-
snare method using the pre-looping technique for endoscopic submucosal dissection of gastric
neoplasia: a randomized controlled trial. Ann Gastroenterol. 2022 Jan-Feb;35(1):48-55. doi:
10.20524/aog.2021.0679.), so there appears to be a relative lack of comparative power for
current single-center retrospective study.
2. The CSM-PLT group took longer than that of the conventional ESD group in this study,
which is inconsistent with others. It seems to be because the CSM-PLT group had larger lesion
size than that of the conventional ESD group. But why the significant difference in lesion size
occurred between two groups? Would you please to give any explanation or analysis for it?
3. The resection speed in different parts of the gastric body was compared in subgroup analysis,
but statistics and analysis of lesion size in different parts were missing. It may be helpful in
explaining the above questions.
Please review this paper.
user
Title: Clip-and-snare method with a pre-looping technique versus conventional method in the
treatment of precancerous lesion and early gastric cancer: a retrospective study
Version: 1 Date: 14 Nov 2023
Reviewer's report:
1. CSM-PLT, firstly reported in 2014, is not completely new, and there have been many
comparisons with conventional ESD. A multicenter prospective randomized controlled study
was reported last year (Hasatani K, Yoshida N, Aoyagi H, et al. Usefulness of the clip-and-
snare method using the pre-looping technique for endoscopic submucosal dissection of gastric
neoplasia: a randomized controlled trial. Ann Gastroenterol. 2022 Jan-Feb;35(1):48-55. doi:
10.20524/aog.2021.0679.), so there appears to be a relative lack of comparative power for
current single-center retrospective study.
2. The CSM-PLT group took longer than that of the conventional ESD group in this study,
which is inconsistent with others. It seems to be because the CSM-PLT group had larger lesion
size than that of the conventional ESD group. But why the significant difference in lesion size
occurred between two groups? Would you please to give any explanation or analysis for it?
3. The resection speed in different parts of the gastric body was compared in subgroup analysis,
but statistics and analysis of lesion size in different parts were missing. It may be helpful in
explaining the above questions.
assistant