Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 1 Date: 06 Jul 2022
Reviewer's report:
This paper presents the influence of hormone-dependent effects and the interaction of genetic
factors on the incidence of gastric cancer. It’s a topic of interest to the researchers in the related
areas but the following suggestion can be taken into consideration when revising the paper:
1. In the part1 of the results, whether the intake of soy products in the case group and the control
group of different genders can be considered in the analysis of participant characteristics, and
whether there is statistical difference between the two groups of different genders.
2. Helicobacter pylori infection has been reported in many literatures is a risk factor for gastric
cancer, and in the part1 of results shown in the case group the infection of the Helicobacter pylori
is lower than the control group, and the difference was statistically significant, this contrary to
common sense can discuss appropriately. In addition, in the part2 results shown that overweight
and obesity are protective factors for GC. Is there any similar literature in the past to support
this result?
3. Some terms are not accurate enough, for example, we cannot judge the incidence of diseases
by the OR value.
Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 1 Date: 06 Jul 2022
Reviewer's report:
This paper presents the influence of hormone-dependent effects and the interaction of genetic
factors on the incidence of gastric cancer. It’s a topic of interest to the researchers in the related
areas but the following suggestion can be taken into consideration when revising the paper:
1. In the part1 of the results, whether the intake of soy products in the case group and the control
group of different genders can be considered in the analysis of participant characteristics, and
whether there is statistical difference between the two groups of different genders.
2. Helicobacter pylori infection has been reported in many literatures is a risk factor for gastric
cancer, and in the part1 of results shown in the case group the infection of the Helicobacter pylori
is lower than the control group, and the difference was statistically significant, this contrary to
common sense can discuss appropriately. In addition, in the part2 results shown that overweight
and obesity are protective factors for GC. Is there any similar literature in the past to support
this result?
3. Some terms are not accurate enough, for example, we cannot judge the incidence of diseases
by the OR value.
Please review this paper.
user
Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 1 Date: 06 Jul 2022
Reviewer's report:
This paper presents the influence of hormone-dependent effects and the interaction of genetic
factors on the incidence of gastric cancer. It’s a topic of interest to the researchers in the related
areas but the following suggestion can be taken into consideration when revising the paper:
1. In the part1 of the results, whether the intake of soy products in the case group and the control
group of different genders can be considered in the analysis of participant characteristics, and
whether there is statistical difference between the two groups of different genders.
2. Helicobacter pylori infection has been reported in many literatures is a risk factor for gastric
cancer, and in the part1 of results shown in the case group the infection of the Helicobacter pylori
is lower than the control group, and the difference was statistically significant, this contrary to
common sense can discuss appropriately. In addition, in the part2 results shown that overweight
and obesity are protective factors for GC. Is there any similar literature in the past to support
this result?
3. Some terms are not accurate enough, for example, we cannot judge the incidence of diseases
by the OR value.
assistant