Reviewer's report
Title:Urine neutrophil gelatinase-associated lipocalin: a diagnostic and
prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients
with AKI-prone conditions.
Version:2Date:5 August 2015
Reviewer: Sakkarin Chirapongsathorn
Reviewer's report:
The authors present results of an optimal cut-off level of uNGAL to explore the
diagnosing acute kidney injury and the association of 30- day liver-related
mortality. This is a well-written and organized paper. As the authors note, there
are the small number of AKI cirrhotic patients. The level of evidence from this
study may be affected by the small number of AKI cirrhosis. However, this study
came from the tertiary hospital center in Thailand and I presume all of the
subjects are Asian ethnicity that would be different from the previous study by the
Barcelona group[1] and Columbia university group[2].
Detailed Comments:
1. Abstracts & Introduction: good to go
2. Methods/ Data Abstraction: No concern
3. Results/ baseline characteristics of patients: Except infection, How many
patients in other AKI-prone conditions?
4. Table 1: I see a wide standard deviation of laboratory value such as AST and
ALT. It means that some patients had very large values for these variables. So it
may be more appropriate to use median and IQR instead.
5. Discussion: Please provide which variables or factors used for adjusting in a
multivariate logistic regression model.
Major Compulsory Revisions: none
Minor essential revisions: Please consider providing information on the number
of patients in each group of the AKI-prone conditions.
Discretionary Revisions: For laboratory values, please consider using median
and IQR instead.
Reference:
1. Barreto R, Elia C, Solà E, et al. Urinary neutrophil gelatinase-associated
lipocalin predicts kidney outcome and death in patients with cirrhosis and
bacterial infections. Journal of Hepatology 2014;61:35-42.
2. Verna EC, Brown RS, Farrand E, et al. Urinary neutrophil
gelatinase-associated lipocalin predicts mortality and identifies acute kidney
injury in cirrhosis. Digestive diseases and sciences 2012;57:2362-70.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Urine neutrophil gelatinase-associated lipocalin: a diagnostic and
prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients
with AKI-prone conditions.
Version:2Date:5 August 2015
Reviewer: Sakkarin Chirapongsathorn
Reviewer's report:
The authors present results of an optimal cut-off level of uNGAL to explore the
diagnosing acute kidney injury and the association of 30- day liver-related
mortality. This is a well-written and organized paper. As the authors note, there
are the small number of AKI cirrhotic patients. The level of evidence from this
study may be affected by the small number of AKI cirrhosis. However, this study
came from the tertiary hospital center in Thailand and I presume all of the
subjects are Asian ethnicity that would be different from the previous study by the
Barcelona group[1] and Columbia university group[2].
Detailed Comments:
1. Abstracts & Introduction: good to go
2. Methods/ Data Abstraction: No concern
3. Results/ baseline characteristics of patients: Except infection, How many
patients in other AKI-prone conditions?
4. Table 1: I see a wide standard deviation of laboratory value such as AST and
ALT. It means that some patients had very large values for these variables. So it
may be more appropriate to use median and IQR instead.
5. Discussion: Please provide which variables or factors used for adjusting in a
multivariate logistic regression model.
Major Compulsory Revisions: none
Minor essential revisions: Please consider providing information on the number
of patients in each group of the AKI-prone conditions.
Discretionary Revisions: For laboratory values, please consider using median
and IQR instead.
Reference:
1. Barreto R, Elia C, Solà E, et al. Urinary neutrophil gelatinase-associated
lipocalin predicts kidney outcome and death in patients with cirrhosis and
bacterial infections. Journal of Hepatology 2014;61:35-42.
2. Verna EC, Brown RS, Farrand E, et al. Urinary neutrophil
gelatinase-associated lipocalin predicts mortality and identifies acute kidney
injury in cirrhosis. Digestive diseases and sciences 2012;57:2362-70.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Urine neutrophil gelatinase-associated lipocalin: a diagnostic and
prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients
with AKI-prone conditions.
Version:2Date:5 August 2015
Reviewer: Sakkarin Chirapongsathorn
Reviewer's report:
The authors present results of an optimal cut-off level of uNGAL to explore the
diagnosing acute kidney injury and the association of 30- day liver-related
mortality. This is a well-written and organized paper. As the authors note, there
are the small number of AKI cirrhotic patients. The level of evidence from this
study may be affected by the small number of AKI cirrhosis. However, this study
came from the tertiary hospital center in Thailand and I presume all of the
subjects are Asian ethnicity that would be different from the previous study by the
Barcelona group[1] and Columbia university group[2].
Detailed Comments:
1. Abstracts & Introduction: good to go
2. Methods/ Data Abstraction: No concern
3. Results/ baseline characteristics of patients: Except infection, How many
patients in other AKI-prone conditions?
4. Table 1: I see a wide standard deviation of laboratory value such as AST and
ALT. It means that some patients had very large values for these variables. So it
may be more appropriate to use median and IQR instead.
5. Discussion: Please provide which variables or factors used for adjusting in a
multivariate logistic regression model.
Major Compulsory Revisions: none
Minor essential revisions: Please consider providing information on the number
of patients in each group of the AKI-prone conditions.
Discretionary Revisions: For laboratory values, please consider using median
and IQR instead.
Reference:
1. Barreto R, Elia C, Solà E, et al. Urinary neutrophil gelatinase-associated
lipocalin predicts kidney outcome and death in patients with cirrhosis and
bacterial infections. Journal of Hepatology 2014;61:35-42.
2. Verna EC, Brown RS, Farrand E, et al. Urinary neutrophil
gelatinase-associated lipocalin predicts mortality and identifies acute kidney
injury in cirrhosis. Digestive diseases and sciences 2012;57:2362-70.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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