Reviewer's report
Title:A Prospective Experimental study of liver fibrosis with ultrasound and Its
Correlation with hepatic reserve function and hemodynamics
Version: 1Date:14 February 2012
Reviewer: K-C Sudhamshu
Reviewer's report:
I have found the study interesting and it may add something in understanding the
hepatic hemodynamics in liver fibrosis. However, the manuscript needs revision
before it can be accepted for publication. Please consider following points.
Major comments:
1. Hepatic circulation index is not a widely used index. Even the author who
coined this index has not used this index in other articles from their group. So,
there should be reference for this index. Since same article has been used as
reference, it’s just matter of rearrangement.
2. Why prothrombin time was not measured as liver function? It is one of the
synthetic functions, as important as serum albumin.
3. Whether the USG operator was blinded with laboratory finding or not is
unclear. If not blinded there can be biasness.
4. In human, there is development of portal hypertension even in chronic
hepatitis stage i.e. pre-cirrhotic stage. After development in portal hypertension
there are changes in the hepatic circulation. Present study fails to elaborate and
discuss this issue.
5. In table 2 PVP has been taken as conventional liver function test. It is not true.
Minor points:
1. First sentence of second paragraph of discussion is unclear.
2. Language needs correction at places.
Reviewer's report
Title:A Prospective Experimental study of liver fibrosis with ultrasound and Its
Correlation with hepatic reserve function and hemodynamics
Version: 1Date:14 February 2012
Reviewer: K-C Sudhamshu
Reviewer's report:
I have found the study interesting and it may add something in understanding the
hepatic hemodynamics in liver fibrosis. However, the manuscript needs revision
before it can be accepted for publication. Please consider following points.
Major comments:
1. Hepatic circulation index is not a widely used index. Even the author who
coined this index has not used this index in other articles from their group. So,
there should be reference for this index. Since same article has been used as
reference, it’s just matter of rearrangement.
2. Why prothrombin time was not measured as liver function? It is one of the
synthetic functions, as important as serum albumin.
3. Whether the USG operator was blinded with laboratory finding or not is
unclear. If not blinded there can be biasness.
4. In human, there is development of portal hypertension even in chronic
hepatitis stage i.e. pre-cirrhotic stage. After development in portal hypertension
there are changes in the hepatic circulation. Present study fails to elaborate and
discuss this issue.
5. In table 2 PVP has been taken as conventional liver function test. It is not true.
Minor points:
1. First sentence of second paragraph of discussion is unclear.
2. Language needs correction at places.
Please review this paper.
user
Reviewer's report
Title:A Prospective Experimental study of liver fibrosis with ultrasound and Its
Correlation with hepatic reserve function and hemodynamics
Version: 1Date:14 February 2012
Reviewer: K-C Sudhamshu
Reviewer's report:
I have found the study interesting and it may add something in understanding the
hepatic hemodynamics in liver fibrosis. However, the manuscript needs revision
before it can be accepted for publication. Please consider following points.
Major comments:
1. Hepatic circulation index is not a widely used index. Even the author who
coined this index has not used this index in other articles from their group. So,
there should be reference for this index. Since same article has been used as
reference, it’s just matter of rearrangement.
2. Why prothrombin time was not measured as liver function? It is one of the
synthetic functions, as important as serum albumin.
3. Whether the USG operator was blinded with laboratory finding or not is
unclear. If not blinded there can be biasness.
4. In human, there is development of portal hypertension even in chronic
hepatitis stage i.e. pre-cirrhotic stage. After development in portal hypertension
there are changes in the hepatic circulation. Present study fails to elaborate and
discuss this issue.
5. In table 2 PVP has been taken as conventional liver function test. It is not true.
Minor points:
1. First sentence of second paragraph of discussion is unclear.
2. Language needs correction at places.
assistant