Title: Selective COX-2 inhibitors do not increase gastrointestinal reactions after colorectal
cancer surgery#A systematic review and meta-analysis
Version: 2 Date: 17 Jul 2023
Reviewer:  Shoban Babu Varthya
Reviewer's report:
I congratulate the authors for conducting Selective COX-2 inhibitors do not increase
gastrointestinal reactions after colorectal cancer surgery: A systematic review and meta-analysis
My suggestions are:
1. In the Abstract: Results: rephrase the sentence as celecoxib and rofecoxib was not significantly
improved disease response rate ( mention the OR)
2. Mention the protocol registration, if any in the methods section
3. In search strategy: rewrite random controlled studies as “Randomized controlled studies”
4. Table 1: in mean age add (years); write the expansion of CRT and 5-FU in the bottom of
the table; label RCTs in included studies as authors mentioned 3 RCTs in the characteristics of
included studies.
5. Remove . before Outcome of the interest
6. What 29 stands for in outcome of interest in line no. 3 and 5
7. Add a reference to Jadad scale and Review managers meta-analysis in data extraction and
quality assessment in line. No.7 and data synthesis and assessment in line no. 1 respectively.
8. Mention the detailed reasons for the exclusion of full text (n=49) in Figure 1
9. In figure 2: RR is mentioned. However, in figure OR is calculated. Kindly verify and label
appropriately.
10. Add strengths, limitations and proper conclusion after discussion.
11. What is the reason for using Jadad quality assessment tool instead of ROB-2?
12. Results of quality assessment not mentioned in the results and their interpretation in the
results section.
Title: Selective COX-2 inhibitors do not increase gastrointestinal reactions after colorectal
cancer surgery#A systematic review and meta-analysis
Version: 2 Date: 17 Jul 2023
Reviewer:  Shoban Babu Varthya
Reviewer's report:
I congratulate the authors for conducting Selective COX-2 inhibitors do not increase
gastrointestinal reactions after colorectal cancer surgery: A systematic review and meta-analysis
My suggestions are:
1. In the Abstract: Results: rephrase the sentence as celecoxib and rofecoxib was not significantly
improved disease response rate ( mention the OR)
2. Mention the protocol registration, if any in the methods section
3. In search strategy: rewrite random controlled studies as “Randomized controlled studies”
4. Table 1: in mean age add (years); write the expansion of CRT and 5-FU in the bottom of
the table; label RCTs in included studies as authors mentioned 3 RCTs in the characteristics of
included studies.
5. Remove . before Outcome of the interest
6. What 29 stands for in outcome of interest in line no. 3 and 5
7. Add a reference to Jadad scale and Review managers meta-analysis in data extraction and
quality assessment in line. No.7 and data synthesis and assessment in line no. 1 respectively.
8. Mention the detailed reasons for the exclusion of full text (n=49) in Figure 1
9. In figure 2: RR is mentioned. However, in figure OR is calculated. Kindly verify and label
appropriately.
10. Add strengths, limitations and proper conclusion after discussion.
11. What is the reason for using Jadad quality assessment tool instead of ROB-2?
12. Results of quality assessment not mentioned in the results and their interpretation in the
results section.
Please review this paper.
user
Title: Selective COX-2 inhibitors do not increase gastrointestinal reactions after colorectal
cancer surgery#A systematic review and meta-analysis
Version: 2 Date: 17 Jul 2023
Reviewer:  Shoban Babu Varthya
Reviewer's report:
I congratulate the authors for conducting Selective COX-2 inhibitors do not increase
gastrointestinal reactions after colorectal cancer surgery: A systematic review and meta-analysis
My suggestions are:
1. In the Abstract: Results: rephrase the sentence as celecoxib and rofecoxib was not significantly
improved disease response rate ( mention the OR)
2. Mention the protocol registration, if any in the methods section
3. In search strategy: rewrite random controlled studies as “Randomized controlled studies”
4. Table 1: in mean age add (years); write the expansion of CRT and 5-FU in the bottom of
the table; label RCTs in included studies as authors mentioned 3 RCTs in the characteristics of
included studies.
5. Remove . before Outcome of the interest
6. What 29 stands for in outcome of interest in line no. 3 and 5
7. Add a reference to Jadad scale and Review managers meta-analysis in data extraction and
quality assessment in line. No.7 and data synthesis and assessment in line no. 1 respectively.
8. Mention the detailed reasons for the exclusion of full text (n=49) in Figure 1
9. In figure 2: RR is mentioned. However, in figure OR is calculated. Kindly verify and label
appropriately.
10. Add strengths, limitations and proper conclusion after discussion.
11. What is the reason for using Jadad quality assessment tool instead of ROB-2?
12. Results of quality assessment not mentioned in the results and their interpretation in the
results section.
assistant