Title: Clinicopathologic and endoscopic characteristics of ten patients with gastric
hamartomatous inverted polyp: a single center case series
Version: 1 Date: 21 Jan 2024
Reviewer's report:
This study investigated the clinicopathological and endoscopic features of GHIP. Its frequency is
low, it is important to identify the clinical and endoscopic features of GHIP. However, I request
that the following points be reconsidered and revised as a result of the peer review.
Major
1. Previously, a primary factor in GHIP was considered to be recurrent and persistent mucosal
damage caused by chronic gastritis associated with H. pylori infection. It is important to
demonstrate clinically that H. pylori infection is associated with GHIP. The authors describe
that H. pylori infection of the gastric mucosa was confirmed in four cases (4/10, 40%) and six
patients (60%) had H. pylori-associated gastritis or atrophic gastritis with intestinal metaplasia.
Please clearly state whether the case is currently infected, previously infected (post-eradication
or spontaneous eradication), or uninfected with H. pylori.
2. Please indicate the gastric atrophy degree (e.g. Kimura and Takemoto's endoscopic-atrophic
border scale).
Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance
in chronic gastritis. Endoscopy. 1969;3:87-97.
Sakaki N, Arakawa T, Katou H, et al. Relationship between progression of gastric mucosal
atrophy and Helicobacter pylori infection: retrospective long-term endoscopic follow-up study.
J Gastroenterol. 1997;32:19-23.
Minor
1. Do endoscopic findings differ between patients with and without surrounding H. pylori
infection?
2. As the authors said in the discussion section, endoscopic diagnosis of a GIP and neoplastic
potential within a GIP may be difficult, and biopsy often faces incomplete pathological
sampling of the remaining masses, therefore, complete resection may be required for subsequent
pathological examination. I agree with this. However, it is important to consider the differential
diseases of GHIP. Therefore, I suggest listing the differential diseases of lesions with endoscopic
findings of GHIP-like morphology and indicating the key points of differentiation in the
discussion section.
3. There is no figure in this study. If possible, I recommend adding endoscopic images, EUS,
and histopathological images of GHIP.
Title: Clinicopathologic and endoscopic characteristics of ten patients with gastric
hamartomatous inverted polyp: a single center case series
Version: 1 Date: 21 Jan 2024
Reviewer's report:
This study investigated the clinicopathological and endoscopic features of GHIP. Its frequency is
low, it is important to identify the clinical and endoscopic features of GHIP. However, I request
that the following points be reconsidered and revised as a result of the peer review.
Major
1. Previously, a primary factor in GHIP was considered to be recurrent and persistent mucosal
damage caused by chronic gastritis associated with H. pylori infection. It is important to
demonstrate clinically that H. pylori infection is associated with GHIP. The authors describe
that H. pylori infection of the gastric mucosa was confirmed in four cases (4/10, 40%) and six
patients (60%) had H. pylori-associated gastritis or atrophic gastritis with intestinal metaplasia.
Please clearly state whether the case is currently infected, previously infected (post-eradication
or spontaneous eradication), or uninfected with H. pylori.
2. Please indicate the gastric atrophy degree (e.g. Kimura and Takemoto's endoscopic-atrophic
border scale).
Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance
in chronic gastritis. Endoscopy. 1969;3:87-97.
Sakaki N, Arakawa T, Katou H, et al. Relationship between progression of gastric mucosal
atrophy and Helicobacter pylori infection: retrospective long-term endoscopic follow-up study.
J Gastroenterol. 1997;32:19-23.
Minor
1. Do endoscopic findings differ between patients with and without surrounding H. pylori
infection?
2. As the authors said in the discussion section, endoscopic diagnosis of a GIP and neoplastic
potential within a GIP may be difficult, and biopsy often faces incomplete pathological
sampling of the remaining masses, therefore, complete resection may be required for subsequent
pathological examination. I agree with this. However, it is important to consider the differential
diseases of GHIP. Therefore, I suggest listing the differential diseases of lesions with endoscopic
findings of GHIP-like morphology and indicating the key points of differentiation in the
discussion section.
3. There is no figure in this study. If possible, I recommend adding endoscopic images, EUS,
and histopathological images of GHIP.
Please review this paper.
user
Title: Clinicopathologic and endoscopic characteristics of ten patients with gastric
hamartomatous inverted polyp: a single center case series
Version: 1 Date: 21 Jan 2024
Reviewer's report:
This study investigated the clinicopathological and endoscopic features of GHIP. Its frequency is
low, it is important to identify the clinical and endoscopic features of GHIP. However, I request
that the following points be reconsidered and revised as a result of the peer review.
Major
1. Previously, a primary factor in GHIP was considered to be recurrent and persistent mucosal
damage caused by chronic gastritis associated with H. pylori infection. It is important to
demonstrate clinically that H. pylori infection is associated with GHIP. The authors describe
that H. pylori infection of the gastric mucosa was confirmed in four cases (4/10, 40%) and six
patients (60%) had H. pylori-associated gastritis or atrophic gastritis with intestinal metaplasia.
Please clearly state whether the case is currently infected, previously infected (post-eradication
or spontaneous eradication), or uninfected with H. pylori.
2. Please indicate the gastric atrophy degree (e.g. Kimura and Takemoto's endoscopic-atrophic
border scale).
Kimura K, Takemoto T. An endoscopic recognition of the atrophic border and its significance
in chronic gastritis. Endoscopy. 1969;3:87-97.
Sakaki N, Arakawa T, Katou H, et al. Relationship between progression of gastric mucosal
atrophy and Helicobacter pylori infection: retrospective long-term endoscopic follow-up study.
J Gastroenterol. 1997;32:19-23.
Minor
1. Do endoscopic findings differ between patients with and without surrounding H. pylori
infection?
2. As the authors said in the discussion section, endoscopic diagnosis of a GIP and neoplastic
potential within a GIP may be difficult, and biopsy often faces incomplete pathological
sampling of the remaining masses, therefore, complete resection may be required for subsequent
pathological examination. I agree with this. However, it is important to consider the differential
diseases of GHIP. Therefore, I suggest listing the differential diseases of lesions with endoscopic
findings of GHIP-like morphology and indicating the key points of differentiation in the
discussion section.
3. There is no figure in this study. If possible, I recommend adding endoscopic images, EUS,
and histopathological images of GHIP.
assistant