Title: Association between the triglyceride glucose index and the risk of acute respiratory failure
in patients with acute pancreatitis
Version: 0 Date: 17 Dec 2024
Reviewer's report:
This study describes the association between Tyg, a possible marker of insulin resistance, and
ARF in people with acute pancreatitis.
Major remarks : While the authors do show a strong association between high Tyg and ARF,
I feel that it is difficult to understand if using this marker is really more interesting than just
knowing if the patients have diabetes or hypertriglyceridemia.
Indeed, it is already known that people living with diabetes are more at risk of severe AP.
Moreover, people with AP can also present with "stress hyperglycemia", all the more if they
have a severe case, which would also show here: those with severe AP would have higher blood
glucose and thus a higher Tyg.
Accordingly, the subgroup analysis shows that in the "diabetes" or in the "hypertriglyceridemia"
subgroups, TYG was not associated with severity anymore.
Therefore, I think that the authors need to really justify using this marker.
Minor remarks:
- The introduction really lacks references, lots of affirmations are not backed by literature
references in the text.
- In the second sentence, the incidence is in people by year
- I don't think that you can say that impaired endocrine function is characterized by insulin
resistance. Moreover, I think that you could move parts of your discussion to the introduction
to explain more clearly why you want to study insulin resistance in this context.
- In the "data selection" section, you do not explain what "abnormal data" are
- in the statistics, I would think that the model 3 uses too many variables which are correlated,
that coud lead to an "overfitting" and to biased results (for example, I would not put INR and
PT, or RBC and Hb, in the same model). I think you lack a model with age, gender, BMI, fasting
blood glucose and TG, or at least diabetes yes/no and hypertriglyceridemia yes/no).
Title: Association between the triglyceride glucose index and the risk of acute respiratory failure
in patients with acute pancreatitis
Version: 0 Date: 17 Dec 2024
Reviewer's report:
This study describes the association between Tyg, a possible marker of insulin resistance, and
ARF in people with acute pancreatitis.
Major remarks : While the authors do show a strong association between high Tyg and ARF,
I feel that it is difficult to understand if using this marker is really more interesting than just
knowing if the patients have diabetes or hypertriglyceridemia.
Indeed, it is already known that people living with diabetes are more at risk of severe AP.
Moreover, people with AP can also present with "stress hyperglycemia", all the more if they
have a severe case, which would also show here: those with severe AP would have higher blood
glucose and thus a higher Tyg.
Accordingly, the subgroup analysis shows that in the "diabetes" or in the "hypertriglyceridemia"
subgroups, TYG was not associated with severity anymore.
Therefore, I think that the authors need to really justify using this marker.
Minor remarks:
- The introduction really lacks references, lots of affirmations are not backed by literature
references in the text.
- In the second sentence, the incidence is in people by year
- I don't think that you can say that impaired endocrine function is characterized by insulin
resistance. Moreover, I think that you could move parts of your discussion to the introduction
to explain more clearly why you want to study insulin resistance in this context.
- In the "data selection" section, you do not explain what "abnormal data" are
- in the statistics, I would think that the model 3 uses too many variables which are correlated,
that coud lead to an "overfitting" and to biased results (for example, I would not put INR and
PT, or RBC and Hb, in the same model). I think you lack a model with age, gender, BMI, fasting
blood glucose and TG, or at least diabetes yes/no and hypertriglyceridemia yes/no).
Please review this paper.
user
Title: Association between the triglyceride glucose index and the risk of acute respiratory failure
in patients with acute pancreatitis
Version: 0 Date: 17 Dec 2024
Reviewer's report:
This study describes the association between Tyg, a possible marker of insulin resistance, and
ARF in people with acute pancreatitis.
Major remarks : While the authors do show a strong association between high Tyg and ARF,
I feel that it is difficult to understand if using this marker is really more interesting than just
knowing if the patients have diabetes or hypertriglyceridemia.
Indeed, it is already known that people living with diabetes are more at risk of severe AP.
Moreover, people with AP can also present with "stress hyperglycemia", all the more if they
have a severe case, which would also show here: those with severe AP would have higher blood
glucose and thus a higher Tyg.
Accordingly, the subgroup analysis shows that in the "diabetes" or in the "hypertriglyceridemia"
subgroups, TYG was not associated with severity anymore.
Therefore, I think that the authors need to really justify using this marker.
Minor remarks:
- The introduction really lacks references, lots of affirmations are not backed by literature
references in the text.
- In the second sentence, the incidence is in people by year
- I don't think that you can say that impaired endocrine function is characterized by insulin
resistance. Moreover, I think that you could move parts of your discussion to the introduction
to explain more clearly why you want to study insulin resistance in this context.
- In the "data selection" section, you do not explain what "abnormal data" are
- in the statistics, I would think that the model 3 uses too many variables which are correlated,
that coud lead to an "overfitting" and to biased results (for example, I would not put INR and
PT, or RBC and Hb, in the same model). I think you lack a model with age, gender, BMI, fasting
blood glucose and TG, or at least diabetes yes/no and hypertriglyceridemia yes/no).
assistant