Title: Macrophage migration inhibitory factor is an early marker of severe acute pancreatitis
based on the revised Atlanta classification
Version: 2 Date: 15 Nov 2020
Reviewer's report:
The authors aimed to evaluate the potential predictive value of macrophage migration inhibitory
factor (MIF) in acute pancreatitis. They studied 143 patients with AP classified according to the
revised Atlanta criteria and ten healthy subject were studied as control group.
Major comment
1. The number of healthy subject is very low and should be improved.
2. The number of patients by etiology is not likely
3. The characteristics of MIF should be extensively reported
4. Atlanta criteria recognize three groups and the author should analyze the data accordingly
5.      Statistical analysis and the tests applied should be better described. In addition, the
distribution of data, normal or no-normal, should be added.
5. In Figure 1 the direction of IL 6 and MIK is opposite of those reporting the BISAP and
APACHE II. Please delete also Group.
Title: Macrophage migration inhibitory factor is an early marker of severe acute pancreatitis
based on the revised Atlanta classification
Version: 2 Date: 15 Nov 2020
Reviewer's report:
The authors aimed to evaluate the potential predictive value of macrophage migration inhibitory
factor (MIF) in acute pancreatitis. They studied 143 patients with AP classified according to the
revised Atlanta criteria and ten healthy subject were studied as control group.
Major comment
1. The number of healthy subject is very low and should be improved.
2. The number of patients by etiology is not likely
3. The characteristics of MIF should be extensively reported
4. Atlanta criteria recognize three groups and the author should analyze the data accordingly
5.      Statistical analysis and the tests applied should be better described. In addition, the
distribution of data, normal or no-normal, should be added.
5. In Figure 1 the direction of IL 6 and MIK is opposite of those reporting the BISAP and
APACHE II. Please delete also Group.
Please review this paper.
user
Title: Macrophage migration inhibitory factor is an early marker of severe acute pancreatitis
based on the revised Atlanta classification
Version: 2 Date: 15 Nov 2020
Reviewer's report:
The authors aimed to evaluate the potential predictive value of macrophage migration inhibitory
factor (MIF) in acute pancreatitis. They studied 143 patients with AP classified according to the
revised Atlanta criteria and ten healthy subject were studied as control group.
Major comment
1. The number of healthy subject is very low and should be improved.
2. The number of patients by etiology is not likely
3. The characteristics of MIF should be extensively reported
4. Atlanta criteria recognize three groups and the author should analyze the data accordingly
5.      Statistical analysis and the tests applied should be better described. In addition, the
distribution of data, normal or no-normal, should be added.
5. In Figure 1 the direction of IL 6 and MIK is opposite of those reporting the BISAP and
APACHE II. Please delete also Group.
assistant