Reviewer's report
Title:Effect of Laparoscopic Splenectomy in Patients with Hepatitis C and
Cirrhosis Carrying IL28B Minor Genotype
Version: 1Date:8 May 2012
Reviewer: Masashi Mizokami
Reviewer's report:
Motomura T. et al. described the efficacy of splenectomy before the induction of
PEG-IFN/RBV(IFN) therapy to liver cirrhosis with IL28B minor allele(s). Because
low success rate of IFN therapy to cirrhosis or those who have IL28B SNPs
minor type is a serious problem, it is of interest that the removing spleen would
improve the viral response rate in genetically disadvantaged patients. This draft
seems to be very interesting, although there are still some problems.
Minor Essential Revisions
1. Page 6, line 14. ” Eighty-one of 125 patients achieved a VR (70.4%). “
It is described “127 patients were enrolled in the current study” in the paragraph
“Methods”. How is the difference between 125 and 127 ?
Discretionary Revisions
1. Page 5, paragraph ”Patient’ Characteristics”.
It is well-known that viral response rate to IFN therapy is correlated with HCV
genotype. Please make the analysis with HCV genotype.
2. Figure 2C
In Figure 2C, the authors mentioned that comparing Hb levels of 4 and 8 weeks
after the IFN therapy, there is no significant difference between Spx group and
non-Spx group. However, Figure 2C strongly suggested that #Hb between 0 and
4 weeks of IFN therapy might be significantly different. So, I would like to
recommend to analize all data with#Hb again.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Effect of Laparoscopic Splenectomy in Patients with Hepatitis C and
Cirrhosis Carrying IL28B Minor Genotype
Version: 1Date:8 May 2012
Reviewer: Masashi Mizokami
Reviewer's report:
Motomura T. et al. described the efficacy of splenectomy before the induction of
PEG-IFN/RBV(IFN) therapy to liver cirrhosis with IL28B minor allele(s). Because
low success rate of IFN therapy to cirrhosis or those who have IL28B SNPs
minor type is a serious problem, it is of interest that the removing spleen would
improve the viral response rate in genetically disadvantaged patients. This draft
seems to be very interesting, although there are still some problems.
Minor Essential Revisions
1. Page 6, line 14. ” Eighty-one of 125 patients achieved a VR (70.4%). “
It is described “127 patients were enrolled in the current study” in the paragraph
“Methods”. How is the difference between 125 and 127 ?
Discretionary Revisions
1. Page 5, paragraph ”Patient’ Characteristics”.
It is well-known that viral response rate to IFN therapy is correlated with HCV
genotype. Please make the analysis with HCV genotype.
2. Figure 2C
In Figure 2C, the authors mentioned that comparing Hb levels of 4 and 8 weeks
after the IFN therapy, there is no significant difference between Spx group and
non-Spx group. However, Figure 2C strongly suggested that #Hb between 0 and
4 weeks of IFN therapy might be significantly different. So, I would like to
recommend to analize all data with#Hb again.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Effect of Laparoscopic Splenectomy in Patients with Hepatitis C and
Cirrhosis Carrying IL28B Minor Genotype
Version: 1Date:8 May 2012
Reviewer: Masashi Mizokami
Reviewer's report:
Motomura T. et al. described the efficacy of splenectomy before the induction of
PEG-IFN/RBV(IFN) therapy to liver cirrhosis with IL28B minor allele(s). Because
low success rate of IFN therapy to cirrhosis or those who have IL28B SNPs
minor type is a serious problem, it is of interest that the removing spleen would
improve the viral response rate in genetically disadvantaged patients. This draft
seems to be very interesting, although there are still some problems.
Minor Essential Revisions
1. Page 6, line 14. ” Eighty-one of 125 patients achieved a VR (70.4%). “
It is described “127 patients were enrolled in the current study” in the paragraph
“Methods”. How is the difference between 125 and 127 ?
Discretionary Revisions
1. Page 5, paragraph ”Patient’ Characteristics”.
It is well-known that viral response rate to IFN therapy is correlated with HCV
genotype. Please make the analysis with HCV genotype.
2. Figure 2C
In Figure 2C, the authors mentioned that comparing Hb levels of 4 and 8 weeks
after the IFN therapy, there is no significant difference between Spx group and
non-Spx group. However, Figure 2C strongly suggested that #Hb between 0 and
4 weeks of IFN therapy might be significantly different. So, I would like to
recommend to analize all data with#Hb again.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant