Title: Construction of a Predictive Model for Concurrent Infection in Liver Failure Patients
Based on Prognostic Nutritional Index and Inflammatory Cytokine Analysis
Version: 2 Date: 28 May 2025
Reviewer:  Rafael Suarez del Villar
Reviewer's report:
Dear Corresponding Author,
Thank you for your thorough and thoughtful responses to the previous review. The revised
manuscript demonstrates clear improvements and addresses all major concerns appropriately.
You have clarified the diagnostic criteria and expanded the discussion regarding the clinical
utility of the predictive model, as well as acknowledged the limitations of not having external
validation. The methodology, particularly the treatment of missing data and the statistical
analysis, is now better detailed and justified. Additionally, your explanation of the relevance
and interpretation of the included biomarkers enhances the scientific rigor of the study.
Overall, the manuscript is now clearly presented, methodologically sound, and clinically
meaningful. Thank you for your diligent revisions.
Best regards,
Title: Construction of a Predictive Model for Concurrent Infection in Liver Failure Patients
Based on Prognostic Nutritional Index and Inflammatory Cytokine Analysis
Version: 2 Date: 28 May 2025
Reviewer:  Rafael Suarez del Villar
Reviewer's report:
Dear Corresponding Author,
Thank you for your thorough and thoughtful responses to the previous review. The revised
manuscript demonstrates clear improvements and addresses all major concerns appropriately.
You have clarified the diagnostic criteria and expanded the discussion regarding the clinical
utility of the predictive model, as well as acknowledged the limitations of not having external
validation. The methodology, particularly the treatment of missing data and the statistical
analysis, is now better detailed and justified. Additionally, your explanation of the relevance
and interpretation of the included biomarkers enhances the scientific rigor of the study.
Overall, the manuscript is now clearly presented, methodologically sound, and clinically
meaningful. Thank you for your diligent revisions.
Best regards,
Please review this paper.
user
Title: Construction of a Predictive Model for Concurrent Infection in Liver Failure Patients
Based on Prognostic Nutritional Index and Inflammatory Cytokine Analysis
Version: 2 Date: 28 May 2025
Reviewer:  Rafael Suarez del Villar
Reviewer's report:
Dear Corresponding Author,
Thank you for your thorough and thoughtful responses to the previous review. The revised
manuscript demonstrates clear improvements and addresses all major concerns appropriately.
You have clarified the diagnostic criteria and expanded the discussion regarding the clinical
utility of the predictive model, as well as acknowledged the limitations of not having external
validation. The methodology, particularly the treatment of missing data and the statistical
analysis, is now better detailed and justified. Additionally, your explanation of the relevance
and interpretation of the included biomarkers enhances the scientific rigor of the study.
Overall, the manuscript is now clearly presented, methodologically sound, and clinically
meaningful. Thank you for your diligent revisions.
Best regards,
assistant