Title: Colorectal Cancer Screening Participation among Citizens not recommended to be
screened: A Cohort Study
Version: 1 Date: 16 Feb 2022
Reviewer:  Isabel Portillo
Reviewer's report:
Dear authors,
Thank you very much for your paper. However, I would like you answer some questions?
- Because of you unknowing the appropriate surveillance in all high risk people (including all
cases of not average risk of CRC), your results and conclusions are not very accurate . In fact,
there are published papers that show difficulties and missed surveillance in those patients.
- Methods could be improved if you have all database (gender,  age group, deprivation,
comorbidities are important ítems to take into account)
- The threshold of FIT is not adjusted by  mcg Hb/g feces (standard). If you mean 100ng /ml
buffer, you should convert in 20mcg/g feces for OC-Sensor.
- Some cases of  IBD and high risk are diagnosed because of their participation. Positive cases
and colonoscopy. Therefore,  false positive rate could be lower than your hipothesis
Title: Colorectal Cancer Screening Participation among Citizens not recommended to be
screened: A Cohort Study
Version: 1 Date: 16 Feb 2022
Reviewer:  Isabel Portillo
Reviewer's report:
Dear authors,
Thank you very much for your paper. However, I would like you answer some questions?
- Because of you unknowing the appropriate surveillance in all high risk people (including all
cases of not average risk of CRC), your results and conclusions are not very accurate . In fact,
there are published papers that show difficulties and missed surveillance in those patients.
- Methods could be improved if you have all database (gender,  age group, deprivation,
comorbidities are important ítems to take into account)
- The threshold of FIT is not adjusted by  mcg Hb/g feces (standard). If you mean 100ng /ml
buffer, you should convert in 20mcg/g feces for OC-Sensor.
- Some cases of  IBD and high risk are diagnosed because of their participation. Positive cases
and colonoscopy. Therefore,  false positive rate could be lower than your hipothesis
Please review this paper.
user
Title: Colorectal Cancer Screening Participation among Citizens not recommended to be
screened: A Cohort Study
Version: 1 Date: 16 Feb 2022
Reviewer:  Isabel Portillo
Reviewer's report:
Dear authors,
Thank you very much for your paper. However, I would like you answer some questions?
- Because of you unknowing the appropriate surveillance in all high risk people (including all
cases of not average risk of CRC), your results and conclusions are not very accurate . In fact,
there are published papers that show difficulties and missed surveillance in those patients.
- Methods could be improved if you have all database (gender,  age group, deprivation,
comorbidities are important ítems to take into account)
- The threshold of FIT is not adjusted by  mcg Hb/g feces (standard). If you mean 100ng /ml
buffer, you should convert in 20mcg/g feces for OC-Sensor.
- Some cases of  IBD and high risk are diagnosed because of their participation. Positive cases
and colonoscopy. Therefore,  false positive rate could be lower than your hipothesis
assistant