Title: Biochemical and histopathological evidence for beneficial effects of empagliflozin
pretreatment on acetic acid-induced colitis in rats
Version: 6 Date: 25 Jun 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Responded but inadequate. Some improvement in the writing but it
is doubtful that the manuscript has gone through thorough English editing, or was proof read.
ADDITIONAL REQUESTS/SUGGESTIONS:
Abbreviations can be used for terms that appeared repeatedly in the manuscript. If an
abbreviation is used, use it when the term is appearing for the first time in the manuscript, and
keeping it throughout the manuscript. Spell out all abbreviations.
Some content in the Discussion should be in the Introduction section, specifically, description
of the measuring parameters - the Discussion section should focus on discussing the results of
the study and not introducing SOD, CAT, MDA, etc. Dexamethasone seemed to be significantly
better than EMPA in reversing the pathological changes induced by acetic acid, but EMPA was
used at a higher concentration than dexamethasone. The study showed an acute effect of EMPA.
But UC is a chronic disease. What do authors foresee the potential use of EMPA in the long-
term treatment of UC?
Title: Biochemical and histopathological evidence for beneficial effects of empagliflozin
pretreatment on acetic acid-induced colitis in rats
Version: 6 Date: 25 Jun 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Responded but inadequate. Some improvement in the writing but it
is doubtful that the manuscript has gone through thorough English editing, or was proof read.
ADDITIONAL REQUESTS/SUGGESTIONS:
Abbreviations can be used for terms that appeared repeatedly in the manuscript. If an
abbreviation is used, use it when the term is appearing for the first time in the manuscript, and
keeping it throughout the manuscript. Spell out all abbreviations.
Some content in the Discussion should be in the Introduction section, specifically, description
of the measuring parameters - the Discussion section should focus on discussing the results of
the study and not introducing SOD, CAT, MDA, etc. Dexamethasone seemed to be significantly
better than EMPA in reversing the pathological changes induced by acetic acid, but EMPA was
used at a higher concentration than dexamethasone. The study showed an acute effect of EMPA.
But UC is a chronic disease. What do authors foresee the potential use of EMPA in the long-
term treatment of UC?
Please review this paper.
user
Title: Biochemical and histopathological evidence for beneficial effects of empagliflozin
pretreatment on acetic acid-induced colitis in rats
Version: 6 Date: 25 Jun 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Responded but inadequate. Some improvement in the writing but it
is doubtful that the manuscript has gone through thorough English editing, or was proof read.
ADDITIONAL REQUESTS/SUGGESTIONS:
Abbreviations can be used for terms that appeared repeatedly in the manuscript. If an
abbreviation is used, use it when the term is appearing for the first time in the manuscript, and
keeping it throughout the manuscript. Spell out all abbreviations.
Some content in the Discussion should be in the Introduction section, specifically, description
of the measuring parameters - the Discussion section should focus on discussing the results of
the study and not introducing SOD, CAT, MDA, etc. Dexamethasone seemed to be significantly
better than EMPA in reversing the pathological changes induced by acetic acid, but EMPA was
used at a higher concentration than dexamethasone. The study showed an acute effect of EMPA.
But UC is a chronic disease. What do authors foresee the potential use of EMPA in the long-
term treatment of UC?
assistant