Title: Global, regional, and national burden of cirrhosis and other chronic liver diseases due to
alcohol use, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Version: 2 Date: 17 Jun 2022
Reviewer's report:
Title
1. Please change the title as follows: Global, regional, and national burden of cirrhosis and other
chronic liver diseases due to alcohol use, 1990–2019: a systematic analysis for the Global Burden
of Disease Study 2019
Have you ever seen the following report?
“Cirrhosis and other chronic liver diseases due to alcohol use — Level
4 cause” (link: https://www.healthdata.org/results/gbd_summaries/2019/cirrhosis-and-other-
chronic-liver-diseases-due-to-alcohol-use-level-4-cause)
2. Please clarify the difference between your study and that report and cite it in your manuscript.
Abstract
1. Please check the English of the text throughout your manuscript; for example, in the abstract,
“No study have …” needs to be revised as “No study has …”, or “incidence rate present …”
as “incidence rate presented …”, etc.
2. Please mention the database you used for your study in the methods.
3. Please mention numbers for your data in the results.
Discussion
1. For this manuscript to be of use and interest to our readers, the discussion needs to be
strengthened. In particular, the discussion should focus on the data interpretation more. Please
ensure that you address the following points in the discussion: What kind of contribution does
this manuscript make to the literature beyond methodological advancements and refinements?
Can you provide explanations for your key findings? How might the findings of this paper
translate to potential improvements in evidence-based policy? And what is the public health
significance of this work?
Tables
1. Please add “alcohol-induced cirrhosis and other chronic liver diseases” to the table legends; for
example, “Table 1. Age-standardized incidence rate (ASIR) and its temporal trends for alcohol-
induced cirrhosis and other chronic liver diseases in 1990 and 2019.”
Title: Global, regional, and national burden of cirrhosis and other chronic liver diseases due to
alcohol use, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Version: 2 Date: 17 Jun 2022
Reviewer's report:
Title
1. Please change the title as follows: Global, regional, and national burden of cirrhosis and other
chronic liver diseases due to alcohol use, 1990–2019: a systematic analysis for the Global Burden
of Disease Study 2019
Have you ever seen the following report?
“Cirrhosis and other chronic liver diseases due to alcohol use — Level
4 cause” (link: https://www.healthdata.org/results/gbd_summaries/2019/cirrhosis-and-other-
chronic-liver-diseases-due-to-alcohol-use-level-4-cause)
2. Please clarify the difference between your study and that report and cite it in your manuscript.
Abstract
1. Please check the English of the text throughout your manuscript; for example, in the abstract,
“No study have …” needs to be revised as “No study has …”, or “incidence rate present …”
as “incidence rate presented …”, etc.
2. Please mention the database you used for your study in the methods.
3. Please mention numbers for your data in the results.
Discussion
1. For this manuscript to be of use and interest to our readers, the discussion needs to be
strengthened. In particular, the discussion should focus on the data interpretation more. Please
ensure that you address the following points in the discussion: What kind of contribution does
this manuscript make to the literature beyond methodological advancements and refinements?
Can you provide explanations for your key findings? How might the findings of this paper
translate to potential improvements in evidence-based policy? And what is the public health
significance of this work?
Tables
1. Please add “alcohol-induced cirrhosis and other chronic liver diseases” to the table legends; for
example, “Table 1. Age-standardized incidence rate (ASIR) and its temporal trends for alcohol-
induced cirrhosis and other chronic liver diseases in 1990 and 2019.”
Please review this paper.
user
Title: Global, regional, and national burden of cirrhosis and other chronic liver diseases due to
alcohol use, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
Version: 2 Date: 17 Jun 2022
Reviewer's report:
Title
1. Please change the title as follows: Global, regional, and national burden of cirrhosis and other
chronic liver diseases due to alcohol use, 1990–2019: a systematic analysis for the Global Burden
of Disease Study 2019
Have you ever seen the following report?
“Cirrhosis and other chronic liver diseases due to alcohol use — Level
4 cause” (link: https://www.healthdata.org/results/gbd_summaries/2019/cirrhosis-and-other-
chronic-liver-diseases-due-to-alcohol-use-level-4-cause)
2. Please clarify the difference between your study and that report and cite it in your manuscript.
Abstract
1. Please check the English of the text throughout your manuscript; for example, in the abstract,
“No study have …” needs to be revised as “No study has …”, or “incidence rate present …”
as “incidence rate presented …”, etc.
2. Please mention the database you used for your study in the methods.
3. Please mention numbers for your data in the results.
Discussion
1. For this manuscript to be of use and interest to our readers, the discussion needs to be
strengthened. In particular, the discussion should focus on the data interpretation more. Please
ensure that you address the following points in the discussion: What kind of contribution does
this manuscript make to the literature beyond methodological advancements and refinements?
Can you provide explanations for your key findings? How might the findings of this paper
translate to potential improvements in evidence-based policy? And what is the public health
significance of this work?
Tables
1. Please add “alcohol-induced cirrhosis and other chronic liver diseases” to the table legends; for
example, “Table 1. Age-standardized incidence rate (ASIR) and its temporal trends for alcohol-
induced cirrhosis and other chronic liver diseases in 1990 and 2019.”
assistant