Title: Risk Factors and Clinical Characteristics of Occult Pancreaticobiliary Reflux in Benign
Gallbladder Diseases
Version: 1 Date: 02 Jun 2024
Reviewer's report:
This may be the first paper showing the relationship between occult pancreaticobiliary reflux
and benign gallbladder diseases. It seems to be interesting but there are some issues .
Major comments
1. PBR occurs constantly in PBM, and average bile amylase levels are more than 100,000 U/
ml. Occult PBR does not coccur constantly, and the levels are usually less than 10,000 U/ml. If
there is some relationship in occult PBM, the relationship is recognized also in PBM.
2. Adenomyomatosis does not frequently occur in PBM.
3. PBR occurs due to inadequate function of the sphincter of Oddi which is sometimes induced
by age and choledocholithiasis (sludge). The results of this study showing biliary sludge and
age over 50  were found frequently in OPBR,  may be the same mechanism.
Title: Risk Factors and Clinical Characteristics of Occult Pancreaticobiliary Reflux in Benign
Gallbladder Diseases
Version: 1 Date: 02 Jun 2024
Reviewer's report:
This may be the first paper showing the relationship between occult pancreaticobiliary reflux
and benign gallbladder diseases. It seems to be interesting but there are some issues .
Major comments
1. PBR occurs constantly in PBM, and average bile amylase levels are more than 100,000 U/
ml. Occult PBR does not coccur constantly, and the levels are usually less than 10,000 U/ml. If
there is some relationship in occult PBM, the relationship is recognized also in PBM.
2. Adenomyomatosis does not frequently occur in PBM.
3. PBR occurs due to inadequate function of the sphincter of Oddi which is sometimes induced
by age and choledocholithiasis (sludge). The results of this study showing biliary sludge and
age over 50  were found frequently in OPBR,  may be the same mechanism.
Please review this paper.
user
Title: Risk Factors and Clinical Characteristics of Occult Pancreaticobiliary Reflux in Benign
Gallbladder Diseases
Version: 1 Date: 02 Jun 2024
Reviewer's report:
This may be the first paper showing the relationship between occult pancreaticobiliary reflux
and benign gallbladder diseases. It seems to be interesting but there are some issues .
Major comments
1. PBR occurs constantly in PBM, and average bile amylase levels are more than 100,000 U/
ml. Occult PBR does not coccur constantly, and the levels are usually less than 10,000 U/ml. If
there is some relationship in occult PBM, the relationship is recognized also in PBM.
2. Adenomyomatosis does not frequently occur in PBM.
3. PBR occurs due to inadequate function of the sphincter of Oddi which is sometimes induced
by age and choledocholithiasis (sludge). The results of this study showing biliary sludge and
age over 50  were found frequently in OPBR,  may be the same mechanism.
assistant