Reviewer’ s report
Title: Retrospective study of the differential diagnosis between cryptogenic multifocal ulcerous
stenosing enteritis and small bowel Crohn’ s disease
Version: 0Date: 07 Jun 2020
Reviewer: Pablo Guisado-Vasco
Reviewer's report:
Dear Dr Dong Wu,I have read carefully your interesting manuscript entitled, 'Retrospective study of the differential
diagnosis between cryptogenic multifocal ulcerous stenosing enteritis and small bowel Chron'sdisease' (ID: BMGE-D-20-00141).
The manuscript describes a retrospective, clinical case, and cohort designed study. The manuscript
is about a rare clinical entity. However, it underscores the important implication in the differentialdiagnosis of CMUSE and inflammatory bowel diseases affecting the small bowel sections.
The manuscript has two important conditions in relation to CMUSE too. First, it's compared to one
of its main differential diagnosis, such as Chron's disease. Second, the different and moreimportant clinical diagnosis interpretation are described: symptoms, endoscopy studies, TC,surgery, or pathology findings. Even, it is mentioned a potential genetic cause of CMUSE - andthis point is frequently overlooked in research of similar scope.
To sum up, it is a nice manuscript about CMUSE, that would allow physicians to update basic
diagnosis aspects of this rare clinical entity.
Sincerely,
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
The reviewer has not got any financial, intellectual interests, or any personal relation with the
manuscript’ s authors that could have had some influence in the reviewing process.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.If
you are not happy for us to publish this report, please contact the editorial office before completing
the review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
Reviewer’ s report
Title: Retrospective study of the differential diagnosis between cryptogenic multifocal ulcerous
stenosing enteritis and small bowel Crohn’ s disease
Version: 0Date: 07 Jun 2020
Reviewer: Pablo Guisado-Vasco
Reviewer's report:
Dear Dr Dong Wu,I have read carefully your interesting manuscript entitled, 'Retrospective study of the differential
diagnosis between cryptogenic multifocal ulcerous stenosing enteritis and small bowel Chron'sdisease' (ID: BMGE-D-20-00141).
The manuscript describes a retrospective, clinical case, and cohort designed study. The manuscript
is about a rare clinical entity. However, it underscores the important implication in the differentialdiagnosis of CMUSE and inflammatory bowel diseases affecting the small bowel sections.
The manuscript has two important conditions in relation to CMUSE too. First, it's compared to one
of its main differential diagnosis, such as Chron's disease. Second, the different and moreimportant clinical diagnosis interpretation are described: symptoms, endoscopy studies, TC,surgery, or pathology findings. Even, it is mentioned a potential genetic cause of CMUSE - andthis point is frequently overlooked in research of similar scope.
To sum up, it is a nice manuscript about CMUSE, that would allow physicians to update basic
diagnosis aspects of this rare clinical entity.
Sincerely,
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
The reviewer has not got any financial, intellectual interests, or any personal relation with the
manuscript’ s authors that could have had some influence in the reviewing process.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.If
you are not happy for us to publish this report, please contact the editorial office before completing
the review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
Please review this paper.
user
Reviewer’ s report
Title: Retrospective study of the differential diagnosis between cryptogenic multifocal ulcerous
stenosing enteritis and small bowel Crohn’ s disease
Version: 0Date: 07 Jun 2020
Reviewer: Pablo Guisado-Vasco
Reviewer's report:
Dear Dr Dong Wu,I have read carefully your interesting manuscript entitled, 'Retrospective study of the differential
diagnosis between cryptogenic multifocal ulcerous stenosing enteritis and small bowel Chron'sdisease' (ID: BMGE-D-20-00141).
The manuscript describes a retrospective, clinical case, and cohort designed study. The manuscript
is about a rare clinical entity. However, it underscores the important implication in the differentialdiagnosis of CMUSE and inflammatory bowel diseases affecting the small bowel sections.
The manuscript has two important conditions in relation to CMUSE too. First, it's compared to one
of its main differential diagnosis, such as Chron's disease. Second, the different and moreimportant clinical diagnosis interpretation are described: symptoms, endoscopy studies, TC,surgery, or pathology findings. Even, it is mentioned a potential genetic cause of CMUSE - andthis point is frequently overlooked in research of similar scope.
To sum up, it is a nice manuscript about CMUSE, that would allow physicians to update basic
diagnosis aspects of this rare clinical entity.
Sincerely,
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
The reviewer has not got any financial, intellectual interests, or any personal relation with the
manuscript’ s authors that could have had some influence in the reviewing process.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.If
you are not happy for us to publish this report, please contact the editorial office before completing
the review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
assistant