Title: Timing of endoscopy in patients with acute variceal bleeding in cirrhosis: An updated
systematic review and meta-analysis
Version: 0 Date: 22 Apr 2025
Reviewer's report:
The authors should be commended as they gathered a big amount of data and they submitted a
nicely written SRMA on this important topic.
Main limitations are the high heterogeneity observed in most of the analyzed outcomes and the
high imprecision (i.e. broad CIs of the point estimates) that undermine their efforts.
There is also a conceptual heterogeneity in the treatments used for the hemostasis.
The authors should comment on the potential role of hemostatic powders in this field (cite the
SRMA: PMID: 31401022)
Title: Timing of endoscopy in patients with acute variceal bleeding in cirrhosis: An updated
systematic review and meta-analysis
Version: 0 Date: 22 Apr 2025
Reviewer's report:
The authors should be commended as they gathered a big amount of data and they submitted a
nicely written SRMA on this important topic.
Main limitations are the high heterogeneity observed in most of the analyzed outcomes and the
high imprecision (i.e. broad CIs of the point estimates) that undermine their efforts.
There is also a conceptual heterogeneity in the treatments used for the hemostasis.
The authors should comment on the potential role of hemostatic powders in this field (cite the
SRMA: PMID: 31401022)
Please review this paper.
user
Title: Timing of endoscopy in patients with acute variceal bleeding in cirrhosis: An updated
systematic review and meta-analysis
Version: 0 Date: 22 Apr 2025
Reviewer's report:
The authors should be commended as they gathered a big amount of data and they submitted a
nicely written SRMA on this important topic.
Main limitations are the high heterogeneity observed in most of the analyzed outcomes and the
high imprecision (i.e. broad CIs of the point estimates) that undermine their efforts.
There is also a conceptual heterogeneity in the treatments used for the hemostasis.
The authors should comment on the potential role of hemostatic powders in this field (cite the
SRMA: PMID: 31401022)
assistant