Reviewer's report
Title:Transplantation of human fetal biliary tree stem/progenitor cells into two
patients with advanced liver cirrhosis
Version:1Date:19 August 2014
Reviewer: Conrado M Fernandez Rodriguez
Reviewer's report:
The authors studied the RBCs antioxidant activity in a cohort of 53 patients with
chronic hepatitis C by measuring superoxide dismutase (SOD), catalase (CAT)
and reduced glutathione (GPx). Baseline and after treatment patients were
compared within group and baseline values were compared with a healthy
control group. Results are of interest, however, I would liake some points to be
addressed.
Major compulsory revision:
1. How was the control group selected?. Were both groups age and gender
matched?
2. What was the SVR rate in the treated patients?
3. SOD, CAT and GPx comparison between responders and non-responders
should be made.
4. ROC curves for outcome should be compared with the RVR rate which has the
best positive predictive value for SVR so far.
Discretionary revisions:
1. Ribavirin induces RBCs oxidative stress, were there any sub-group treated
solely with peginterferon?
2. GPx and CAT activity were not restored to healthy control levels.
Minor essential revision: Sentence 178-181 is repeated
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interest regarding this manuscript.
Reviewer's report
Title:Transplantation of human fetal biliary tree stem/progenitor cells into two
patients with advanced liver cirrhosis
Version:1Date:19 August 2014
Reviewer: Conrado M Fernandez Rodriguez
Reviewer's report:
The authors studied the RBCs antioxidant activity in a cohort of 53 patients with
chronic hepatitis C by measuring superoxide dismutase (SOD), catalase (CAT)
and reduced glutathione (GPx). Baseline and after treatment patients were
compared within group and baseline values were compared with a healthy
control group. Results are of interest, however, I would liake some points to be
addressed.
Major compulsory revision:
1. How was the control group selected?. Were both groups age and gender
matched?
2. What was the SVR rate in the treated patients?
3. SOD, CAT and GPx comparison between responders and non-responders
should be made.
4. ROC curves for outcome should be compared with the RVR rate which has the
best positive predictive value for SVR so far.
Discretionary revisions:
1. Ribavirin induces RBCs oxidative stress, were there any sub-group treated
solely with peginterferon?
2. GPx and CAT activity were not restored to healthy control levels.
Minor essential revision: Sentence 178-181 is repeated
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interest regarding this manuscript.
Please review this paper.
user
Reviewer's report
Title:Transplantation of human fetal biliary tree stem/progenitor cells into two
patients with advanced liver cirrhosis
Version:1Date:19 August 2014
Reviewer: Conrado M Fernandez Rodriguez
Reviewer's report:
The authors studied the RBCs antioxidant activity in a cohort of 53 patients with
chronic hepatitis C by measuring superoxide dismutase (SOD), catalase (CAT)
and reduced glutathione (GPx). Baseline and after treatment patients were
compared within group and baseline values were compared with a healthy
control group. Results are of interest, however, I would liake some points to be
addressed.
Major compulsory revision:
1. How was the control group selected?. Were both groups age and gender
matched?
2. What was the SVR rate in the treated patients?
3. SOD, CAT and GPx comparison between responders and non-responders
should be made.
4. ROC curves for outcome should be compared with the RVR rate which has the
best positive predictive value for SVR so far.
Discretionary revisions:
1. Ribavirin induces RBCs oxidative stress, were there any sub-group treated
solely with peginterferon?
2. GPx and CAT activity were not restored to healthy control levels.
Minor essential revision: Sentence 178-181 is repeated
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interest regarding this manuscript.
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