Title: Clinical diagnostic value of methylated SEPT9 combined with NLR, PLR and LMR in
colorectal cancer
Version: 2 Date: 02 Jul 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This article is the revised manuscript of a previously evaluated
piece of work, in which mSEPT9, NLR, PLR and LMR are investigated as predictive plasma
biomarkers for colorectal cancer.
Minor corrections have been suggested, and the authors have responded to all of them,
introducing changes both in the manuscript text and tables as needed. They have also added a
new supplementary table (S4) that list all the abbreviations used throughout the text.
Overall, the study is not deemed ready for publication.
ADDITIONAL REQUESTS/SUGGESTIONS:
None.
Title: Clinical diagnostic value of methylated SEPT9 combined with NLR, PLR and LMR in
colorectal cancer
Version: 2 Date: 02 Jul 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This article is the revised manuscript of a previously evaluated
piece of work, in which mSEPT9, NLR, PLR and LMR are investigated as predictive plasma
biomarkers for colorectal cancer.
Minor corrections have been suggested, and the authors have responded to all of them,
introducing changes both in the manuscript text and tables as needed. They have also added a
new supplementary table (S4) that list all the abbreviations used throughout the text.
Overall, the study is not deemed ready for publication.
ADDITIONAL REQUESTS/SUGGESTIONS:
None.
Please review this paper.
user
Title: Clinical diagnostic value of methylated SEPT9 combined with NLR, PLR and LMR in
colorectal cancer
Version: 2 Date: 02 Jul 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This article is the revised manuscript of a previously evaluated
piece of work, in which mSEPT9, NLR, PLR and LMR are investigated as predictive plasma
biomarkers for colorectal cancer.
Minor corrections have been suggested, and the authors have responded to all of them,
introducing changes both in the manuscript text and tables as needed. They have also added a
new supplementary table (S4) that list all the abbreviations used throughout the text.
Overall, the study is not deemed ready for publication.
ADDITIONAL REQUESTS/SUGGESTIONS:
None.
assistant