Title: Risk factors for diabetic ketoacidosis in acute pancreatitis patients with type 2 diabetes
Version: 3 Date: 20 Apr 2023
Reviewer's report:
Dear editor,
I have read with interest the manuscript, and I propose to reject the manuscript. Here are some
suggestions about the manuscript
1. First of all the study population is too low.
2. The authors stated in the material-method section that the patients monitored their blood
glucose every 4 hours to observe whether DKA occurred within 48 hours after admission (self-
monitorization?). But it was not mentioned whether the patients received insulin therapy. For
example if a patient has hyperglycemia, he should receive insulin to prevent DKA development.
It is crucial to mention the therapy protocol, because it raises suspicion of ethical problems
(leaving patients without appropriate diabetes therapy).
3. Some spelling errors exist: starting a sentence with a number, “patients had a history of
drinking“, no space after numbers before brackets, some punctuation errors and so on.
4. How was poor glycemic control determined?
5. I think that the study has some important statistical errors. Median values should represent as
median (interquartile range) but the study included not a range in the brackets, just one value.
Two patients in group 1 and 3 patients in group 2 are female and the p value is <0.001 (?). The
smokers level are also different in two groups with such a low population count? Each group had
one each severe AP, and the difference was <0.001? The statistical analysis should be checked
by a statistical editor or reviewer.
6. The discussion part is also insufficient. It should include similar studies and compare
them with the present study (for example: Fu Y, Liu X, Cui B, Wang C, Liu Z, Zhao B.
Clinical Characteristics of Concomitant Diabetic Ketoacidosis in Type 2 Diabetes Patients
with Acute Pancreatitis. Diabetes Metab Syndr Obes. 2022 Jan 11;15:111-119. doi: 10.2147/
DMSO.S336619). If the authors think that they performed a different study, this should also be
mentioned.
7. More recently published references should be cited in the manuscript.
Title: Risk factors for diabetic ketoacidosis in acute pancreatitis patients with type 2 diabetes
Version: 3 Date: 20 Apr 2023
Reviewer's report:
Dear editor,
I have read with interest the manuscript, and I propose to reject the manuscript. Here are some
suggestions about the manuscript
1. First of all the study population is too low.
2. The authors stated in the material-method section that the patients monitored their blood
glucose every 4 hours to observe whether DKA occurred within 48 hours after admission (self-
monitorization?). But it was not mentioned whether the patients received insulin therapy. For
example if a patient has hyperglycemia, he should receive insulin to prevent DKA development.
It is crucial to mention the therapy protocol, because it raises suspicion of ethical problems
(leaving patients without appropriate diabetes therapy).
3. Some spelling errors exist: starting a sentence with a number, “patients had a history of
drinking“, no space after numbers before brackets, some punctuation errors and so on.
4. How was poor glycemic control determined?
5. I think that the study has some important statistical errors. Median values should represent as
median (interquartile range) but the study included not a range in the brackets, just one value.
Two patients in group 1 and 3 patients in group 2 are female and the p value is <0.001 (?). The
smokers level are also different in two groups with such a low population count? Each group had
one each severe AP, and the difference was <0.001? The statistical analysis should be checked
by a statistical editor or reviewer.
6. The discussion part is also insufficient. It should include similar studies and compare
them with the present study (for example: Fu Y, Liu X, Cui B, Wang C, Liu Z, Zhao B.
Clinical Characteristics of Concomitant Diabetic Ketoacidosis in Type 2 Diabetes Patients
with Acute Pancreatitis. Diabetes Metab Syndr Obes. 2022 Jan 11;15:111-119. doi: 10.2147/
DMSO.S336619). If the authors think that they performed a different study, this should also be
mentioned.
7. More recently published references should be cited in the manuscript.
Please review this paper.
user
Title: Risk factors for diabetic ketoacidosis in acute pancreatitis patients with type 2 diabetes
Version: 3 Date: 20 Apr 2023
Reviewer's report:
Dear editor,
I have read with interest the manuscript, and I propose to reject the manuscript. Here are some
suggestions about the manuscript
1. First of all the study population is too low.
2. The authors stated in the material-method section that the patients monitored their blood
glucose every 4 hours to observe whether DKA occurred within 48 hours after admission (self-
monitorization?). But it was not mentioned whether the patients received insulin therapy. For
example if a patient has hyperglycemia, he should receive insulin to prevent DKA development.
It is crucial to mention the therapy protocol, because it raises suspicion of ethical problems
(leaving patients without appropriate diabetes therapy).
3. Some spelling errors exist: starting a sentence with a number, “patients had a history of
drinking“, no space after numbers before brackets, some punctuation errors and so on.
4. How was poor glycemic control determined?
5. I think that the study has some important statistical errors. Median values should represent as
median (interquartile range) but the study included not a range in the brackets, just one value.
Two patients in group 1 and 3 patients in group 2 are female and the p value is <0.001 (?). The
smokers level are also different in two groups with such a low population count? Each group had
one each severe AP, and the difference was <0.001? The statistical analysis should be checked
by a statistical editor or reviewer.
6. The discussion part is also insufficient. It should include similar studies and compare
them with the present study (for example: Fu Y, Liu X, Cui B, Wang C, Liu Z, Zhao B.
Clinical Characteristics of Concomitant Diabetic Ketoacidosis in Type 2 Diabetes Patients
with Acute Pancreatitis. Diabetes Metab Syndr Obes. 2022 Jan 11;15:111-119. doi: 10.2147/
DMSO.S336619). If the authors think that they performed a different study, this should also be
mentioned.
7. More recently published references should be cited in the manuscript.
assistant