Title: A Survey on Helicobacter pylori infection rate in Hainan Province and analysis of related
risk factors
Version: 3 Date: 02 Sep 2023
Reviewer's report:
The authors surveyed the prevalence of H. pylori infection in Hainan Province and provided
important primary data to identify factors strongly associated with H. pylori infection in the area.
The following are my comments.
1. What is the reason for using the Carbon-14 urea breath test (14C-UBT) instead of 13C-UBT
for H. pylori infection test?
2. We assume that the subject's characteristics and lifestyle habits were obtained through a self-
administered questionnaire. However, did the researcher confirm the content of these answers
with the study subject in person? If there is a difference in educational history, the accuracy of
the answers may vary depending on how the questionnaire is taken. Please clarify.
3. You discussed that the prevalence of H. pylori might be lower in those with a family history of
gastric cancer because they are more likely to be screened and treated for H. pylori eradication,
but have you examined whether there is an association between a history of H. pylori eradication
and a family history of gastric cancer?
Minor confirmation
Could the BIM in the "2.2 Questionnaire" section be a mistake for BMI?
Title: A Survey on Helicobacter pylori infection rate in Hainan Province and analysis of related
risk factors
Version: 3 Date: 02 Sep 2023
Reviewer's report:
The authors surveyed the prevalence of H. pylori infection in Hainan Province and provided
important primary data to identify factors strongly associated with H. pylori infection in the area.
The following are my comments.
1. What is the reason for using the Carbon-14 urea breath test (14C-UBT) instead of 13C-UBT
for H. pylori infection test?
2. We assume that the subject's characteristics and lifestyle habits were obtained through a self-
administered questionnaire. However, did the researcher confirm the content of these answers
with the study subject in person? If there is a difference in educational history, the accuracy of
the answers may vary depending on how the questionnaire is taken. Please clarify.
3. You discussed that the prevalence of H. pylori might be lower in those with a family history of
gastric cancer because they are more likely to be screened and treated for H. pylori eradication,
but have you examined whether there is an association between a history of H. pylori eradication
and a family history of gastric cancer?
Minor confirmation
Could the BIM in the "2.2 Questionnaire" section be a mistake for BMI?
Please review this paper.
user
Title: A Survey on Helicobacter pylori infection rate in Hainan Province and analysis of related
risk factors
Version: 3 Date: 02 Sep 2023
Reviewer's report:
The authors surveyed the prevalence of H. pylori infection in Hainan Province and provided
important primary data to identify factors strongly associated with H. pylori infection in the area.
The following are my comments.
1. What is the reason for using the Carbon-14 urea breath test (14C-UBT) instead of 13C-UBT
for H. pylori infection test?
2. We assume that the subject's characteristics and lifestyle habits were obtained through a self-
administered questionnaire. However, did the researcher confirm the content of these answers
with the study subject in person? If there is a difference in educational history, the accuracy of
the answers may vary depending on how the questionnaire is taken. Please clarify.
3. You discussed that the prevalence of H. pylori might be lower in those with a family history of
gastric cancer because they are more likely to be screened and treated for H. pylori eradication,
but have you examined whether there is an association between a history of H. pylori eradication
and a family history of gastric cancer?
Minor confirmation
Could the BIM in the "2.2 Questionnaire" section be a mistake for BMI?
assistant