Reviewer ’s report  
 
Title: Ischemic colitis induced by indigo naturalis in a patient with ulcerative colitis: A case 
report  
 
Version: 1 Date: 06 May 2020  
 
Reviewer: Peter Thelin Schmidt  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as 
an attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be in cluded in a text 
format.  
Please overwrite this text when adding your comments to the authors.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necess ary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
 
 
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of 
this manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of 
the manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in r elation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
Reviewer Publication Consent. I agree for my report to be made available under an Open 
Access  Creative Commo ns CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if 
this manuscript  is accepted for publication. Any comments that I do not wish to be included 
in the published  report have been included as confidential comments to the editor, which will 
not be published.  If you are not happy for us to publish this report, please contact the editorial 
office before completing  the review.  If you wish, you can include your name in you r 
published report. Please note you must  decide whether to include your name at the start of the 
process and confirm this decision whenever  prompted. If you change your decision later, we 
will not be able to publish your name.  
 
I agree to the terms of the C C-BY 4.0 license; please publish my name with my report.  
Reviewer ’s report  
 
Title: Ischemic colitis induced by indigo naturalis in a patient with ulcerative colitis: A case 
report  
 
Version: 1 Date: 06 May 2020  
 
Reviewer: Peter Thelin Schmidt  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as 
an attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be in cluded in a text 
format.  
Please overwrite this text when adding your comments to the authors.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necess ary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
 
 
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of 
this manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of 
the manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in r elation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
Reviewer Publication Consent. I agree for my report to be made available under an Open 
Access  Creative Commo ns CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if 
this manuscript  is accepted for publication. Any comments that I do not wish to be included 
in the published  report have been included as confidential comments to the editor, which will 
not be published.  If you are not happy for us to publish this report, please contact the editorial 
office before completing  the review.  If you wish, you can include your name in you r 
published report. Please note you must  decide whether to include your name at the start of the 
process and confirm this decision whenever  prompted. If you change your decision later, we 
will not be able to publish your name.  
 
I agree to the terms of the C C-BY 4.0 license; please publish my name with my report.  
Please review this paper.
user
Reviewer ’s report  
 
Title: Ischemic colitis induced by indigo naturalis in a patient with ulcerative colitis: A case 
report  
 
Version: 1 Date: 06 May 2020  
 
Reviewer: Peter Thelin Schmidt  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as 
an attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be in cluded in a text 
format.  
Please overwrite this text when adding your comments to the authors.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necess ary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
 
 
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of 
this manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of 
the manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in r elation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
Reviewer Publication Consent. I agree for my report to be made available under an Open 
Access  Creative Commo ns CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if 
this manuscript  is accepted for publication. Any comments that I do not wish to be included 
in the published  report have been included as confidential comments to the editor, which will 
not be published.  If you are not happy for us to publish this report, please contact the editorial 
office before completing  the review.  If you wish, you can include your name in you r 
published report. Please note you must  decide whether to include your name at the start of the 
process and confirm this decision whenever  prompted. If you change your decision later, we 
will not be able to publish your name.  
 
I agree to the terms of the C C-BY 4.0 license; please publish my name with my report.  
assistant