Reviewer's report
Title:Chromosomal imbalances are uncommon in Chagasic megaesophagus
Version: 2Date:24 August 2009
Reviewer: Ming-Rong Wang
Reviewer's report:
1. None of CM group members developed ESCC, and alterations detected in the
CM group could not represent the exact changes in the early stage of ESCC. In
fact, more copy number changes have been observed in premalignant lesions of
several tumors, including dysplasia of the esophagus. In addition, what the CM
cases did not develop ESCC may be the result of the short follow-up time.
2. The case number of the present study was too limited, especially not enough
for the statistic analyses of the correlations between the copy number changes
and clinicopatholgic parameters. The case number directly affects the reliability
of the conclusions.
3. The quality of Figures 2C and D is not acceptable. It is very difficult to correctly
determine the copy number of the genes tested from such pictures.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Chromosomal imbalances are uncommon in Chagasic megaesophagus
Version: 2Date:24 August 2009
Reviewer: Ming-Rong Wang
Reviewer's report:
1. None of CM group members developed ESCC, and alterations detected in the
CM group could not represent the exact changes in the early stage of ESCC. In
fact, more copy number changes have been observed in premalignant lesions of
several tumors, including dysplasia of the esophagus. In addition, what the CM
cases did not develop ESCC may be the result of the short follow-up time.
2. The case number of the present study was too limited, especially not enough
for the statistic analyses of the correlations between the copy number changes
and clinicopatholgic parameters. The case number directly affects the reliability
of the conclusions.
3. The quality of Figures 2C and D is not acceptable. It is very difficult to correctly
determine the copy number of the genes tested from such pictures.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Chromosomal imbalances are uncommon in Chagasic megaesophagus
Version: 2Date:24 August 2009
Reviewer: Ming-Rong Wang
Reviewer's report:
1. None of CM group members developed ESCC, and alterations detected in the
CM group could not represent the exact changes in the early stage of ESCC. In
fact, more copy number changes have been observed in premalignant lesions of
several tumors, including dysplasia of the esophagus. In addition, what the CM
cases did not develop ESCC may be the result of the short follow-up time.
2. The case number of the present study was too limited, especially not enough
for the statistic analyses of the correlations between the copy number changes
and clinicopatholgic parameters. The case number directly affects the reliability
of the conclusions.
3. The quality of Figures 2C and D is not acceptable. It is very difficult to correctly
determine the copy number of the genes tested from such pictures.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
assistant