Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 2 Date: 14 May 2024
Reviewer's report:
General Comments:
This manuscript titled "Celiac disease among Nigerian children and adolescents with type 1
diabetes mellitus" presents a valuable contribution to the field by investigating the prevalence
of Celiac Disease (CD) in a population where little data currently exists. The topic is significant
and the findings could have important implications for the management of children with Type
1 Diabetes Mellitus (T1DM) in Nigeria and similar regions.
Specific Comments:
1. Introduction:
The introduction clearly outlines the rationale for the study and provides a good background.
However, it could benefit from a brief discussion on the potential biological mechanisms linking
T1DM and CD.
2. Methods:
The study design is appropriate for the objectives. However, the manuscript would benefit
from more detailed descriptions of the diagnostic criteria used for CD, especially regarding the
thresholds for the antibody tests.
Please clarify the method used for selecting the seven tertiary health facilities involved in the
study. Was there a specific reason for choosing these facilities?
3. Results:
The results are well-presented, but there are areas where additional statistical details could be
beneficial. For example, the manuscript reports p-values but does not always provide confidence
intervals or effect sizes, which could help in understanding the clinical significance of the
findings.
Table 2 and Table 3 could be more clearly formatted to enhance readability and quick reference.
4. Discussion:
The discussion provides a good synthesis of the findings in relation to the existing literature.
However, it would be strengthened by addressing potential limitations more comprehensively,
such as the potential bias introduced by the hospital-based study design.
Consider discussing the implications of these findings for pediatric practice in Nigeria and
similar settings.
5. Conclusion:
The conclusions are well-supported by the data but consider adding recommendations for future
research or policy changes based on the study's findings.
6. Ethical Considerations:
The manuscript notes ethical approval and consent procedures, which is commendable. Ensure
that these are sufficiently detailed to meet international guidelines, as this enhances the
credibility and replicability of the study.
7. Language and Presentation:
The manuscript is generally well-written. Minor grammatical and typographical errors should
be corrected to improve readability. For instance, consider a thorough proofread to correct any
spelling inconsistencies.
Recommendation:
I recommend this manuscript for acceptance after minor revisions, as suggested. The study adds
valuable information to the field and could significantly impact clinical practices in managing
children with T1DM.
Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 2 Date: 14 May 2024
Reviewer's report:
General Comments:
This manuscript titled "Celiac disease among Nigerian children and adolescents with type 1
diabetes mellitus" presents a valuable contribution to the field by investigating the prevalence
of Celiac Disease (CD) in a population where little data currently exists. The topic is significant
and the findings could have important implications for the management of children with Type
1 Diabetes Mellitus (T1DM) in Nigeria and similar regions.
Specific Comments:
1. Introduction:
The introduction clearly outlines the rationale for the study and provides a good background.
However, it could benefit from a brief discussion on the potential biological mechanisms linking
T1DM and CD.
2. Methods:
The study design is appropriate for the objectives. However, the manuscript would benefit
from more detailed descriptions of the diagnostic criteria used for CD, especially regarding the
thresholds for the antibody tests.
Please clarify the method used for selecting the seven tertiary health facilities involved in the
study. Was there a specific reason for choosing these facilities?
3. Results:
The results are well-presented, but there are areas where additional statistical details could be
beneficial. For example, the manuscript reports p-values but does not always provide confidence
intervals or effect sizes, which could help in understanding the clinical significance of the
findings.
Table 2 and Table 3 could be more clearly formatted to enhance readability and quick reference.
4. Discussion:
The discussion provides a good synthesis of the findings in relation to the existing literature.
However, it would be strengthened by addressing potential limitations more comprehensively,
such as the potential bias introduced by the hospital-based study design.
Consider discussing the implications of these findings for pediatric practice in Nigeria and
similar settings.
5. Conclusion:
The conclusions are well-supported by the data but consider adding recommendations for future
research or policy changes based on the study's findings.
6. Ethical Considerations:
The manuscript notes ethical approval and consent procedures, which is commendable. Ensure
that these are sufficiently detailed to meet international guidelines, as this enhances the
credibility and replicability of the study.
7. Language and Presentation:
The manuscript is generally well-written. Minor grammatical and typographical errors should
be corrected to improve readability. For instance, consider a thorough proofread to correct any
spelling inconsistencies.
Recommendation:
I recommend this manuscript for acceptance after minor revisions, as suggested. The study adds
valuable information to the field and could significantly impact clinical practices in managing
children with T1DM.
Please review this paper.
user
Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 2 Date: 14 May 2024
Reviewer's report:
General Comments:
This manuscript titled "Celiac disease among Nigerian children and adolescents with type 1
diabetes mellitus" presents a valuable contribution to the field by investigating the prevalence
of Celiac Disease (CD) in a population where little data currently exists. The topic is significant
and the findings could have important implications for the management of children with Type
1 Diabetes Mellitus (T1DM) in Nigeria and similar regions.
Specific Comments:
1. Introduction:
The introduction clearly outlines the rationale for the study and provides a good background.
However, it could benefit from a brief discussion on the potential biological mechanisms linking
T1DM and CD.
2. Methods:
The study design is appropriate for the objectives. However, the manuscript would benefit
from more detailed descriptions of the diagnostic criteria used for CD, especially regarding the
thresholds for the antibody tests.
Please clarify the method used for selecting the seven tertiary health facilities involved in the
study. Was there a specific reason for choosing these facilities?
3. Results:
The results are well-presented, but there are areas where additional statistical details could be
beneficial. For example, the manuscript reports p-values but does not always provide confidence
intervals or effect sizes, which could help in understanding the clinical significance of the
findings.
Table 2 and Table 3 could be more clearly formatted to enhance readability and quick reference.
4. Discussion:
The discussion provides a good synthesis of the findings in relation to the existing literature.
However, it would be strengthened by addressing potential limitations more comprehensively,
such as the potential bias introduced by the hospital-based study design.
Consider discussing the implications of these findings for pediatric practice in Nigeria and
similar settings.
5. Conclusion:
The conclusions are well-supported by the data but consider adding recommendations for future
research or policy changes based on the study's findings.
6. Ethical Considerations:
The manuscript notes ethical approval and consent procedures, which is commendable. Ensure
that these are sufficiently detailed to meet international guidelines, as this enhances the
credibility and replicability of the study.
7. Language and Presentation:
The manuscript is generally well-written. Minor grammatical and typographical errors should
be corrected to improve readability. For instance, consider a thorough proofread to correct any
spelling inconsistencies.
Recommendation:
I recommend this manuscript for acceptance after minor revisions, as suggested. The study adds
valuable information to the field and could significantly impact clinical practices in managing
children with T1DM.
assistant