Title: CHFR promotes metastasis of human gastric carcinoma by activating AKT and ERK via
NRF2- ROS axis
Version: 2 Date: 30 Jan 2023
Reviewer:  Xiaojing Chang
Reviewer's report:
The authors constructing CHFR stably expressed cell lines to analyzed and evaluated its role and
its correlation with ROS, AKT and ERK pathway. Results showed that CHFR over-expression
inhibited the cell proliferation rate of SGC-7901 and AGS cells, while significantly enhanced
the potential of cell migration and invasion, and exerted a significantly higher lung metastasis
ability in nude mice models, CHFR might take part in gastric cancer progression by activating
AKT and ERK via NRF2- ROS axis.
The data and figures showed here are interesting and meaningful. But, there are many
orthographic errors through the manuscript.
1. In Fig 2, authors should add the caption, which ones from SGC-7901 or AGS cells.
2. In discussion, Authors should give detail explanation and discussion for these results
that CHFR over-expression inhibited the cell proliferation but enhanced the potential of cell
migration and invasion. While, authors should also give detail discussion for result data
compared with published papers, not just again state the results.
Title: CHFR promotes metastasis of human gastric carcinoma by activating AKT and ERK via
NRF2- ROS axis
Version: 2 Date: 30 Jan 2023
Reviewer:  Xiaojing Chang
Reviewer's report:
The authors constructing CHFR stably expressed cell lines to analyzed and evaluated its role and
its correlation with ROS, AKT and ERK pathway. Results showed that CHFR over-expression
inhibited the cell proliferation rate of SGC-7901 and AGS cells, while significantly enhanced
the potential of cell migration and invasion, and exerted a significantly higher lung metastasis
ability in nude mice models, CHFR might take part in gastric cancer progression by activating
AKT and ERK via NRF2- ROS axis.
The data and figures showed here are interesting and meaningful. But, there are many
orthographic errors through the manuscript.
1. In Fig 2, authors should add the caption, which ones from SGC-7901 or AGS cells.
2. In discussion, Authors should give detail explanation and discussion for these results
that CHFR over-expression inhibited the cell proliferation but enhanced the potential of cell
migration and invasion. While, authors should also give detail discussion for result data
compared with published papers, not just again state the results.
Please review this paper.
user
Title: CHFR promotes metastasis of human gastric carcinoma by activating AKT and ERK via
NRF2- ROS axis
Version: 2 Date: 30 Jan 2023
Reviewer:  Xiaojing Chang
Reviewer's report:
The authors constructing CHFR stably expressed cell lines to analyzed and evaluated its role and
its correlation with ROS, AKT and ERK pathway. Results showed that CHFR over-expression
inhibited the cell proliferation rate of SGC-7901 and AGS cells, while significantly enhanced
the potential of cell migration and invasion, and exerted a significantly higher lung metastasis
ability in nude mice models, CHFR might take part in gastric cancer progression by activating
AKT and ERK via NRF2- ROS axis.
The data and figures showed here are interesting and meaningful. But, there are many
orthographic errors through the manuscript.
1. In Fig 2, authors should add the caption, which ones from SGC-7901 or AGS cells.
2. In discussion, Authors should give detail explanation and discussion for these results
that CHFR over-expression inhibited the cell proliferation but enhanced the potential of cell
migration and invasion. While, authors should also give detail discussion for result data
compared with published papers, not just again state the results.
assistant