Reviewer's report
Title:Reduced diversity and increased virulence-gene carriage in intestinal
enterobacteria of coeliac children
Version: 3Date:1 October 2008
Reviewer: Christel Neut
Reviewer's report:
The manuscript is improved after revision. Some minor points need
consideration. In the introduction it should be clearly stated the previous results
of the same research group are already published. It should also be stated that in
the same individual, only one clone is usually predominant (as mentioned in the
author's response).
I agree that the analysis concerns a group of patients, but if only one clone is
analyzed from one patient and five from the others, the result for the group is not
homogenous, but this can be attenuated by the statement that usually only one
clone predominates in each individual.
Some spelling errors are still present. Page 7 the Aeromonas species isolated is
named caviae (I do not know if it likes caviar). Page 10, the medium used for
isolation is MacConkey agar.
The first sentence of the conclusion should be: This study has demonstrated
changes in Enterobacteriaceae (in the manuscript a "c" is lacking) diversity,
changes in E. coli phylogenetic groups and increases in.....
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Reduced diversity and increased virulence-gene carriage in intestinal
enterobacteria of coeliac children
Version: 3Date:1 October 2008
Reviewer: Christel Neut
Reviewer's report:
The manuscript is improved after revision. Some minor points need
consideration. In the introduction it should be clearly stated the previous results
of the same research group are already published. It should also be stated that in
the same individual, only one clone is usually predominant (as mentioned in the
author's response).
I agree that the analysis concerns a group of patients, but if only one clone is
analyzed from one patient and five from the others, the result for the group is not
homogenous, but this can be attenuated by the statement that usually only one
clone predominates in each individual.
Some spelling errors are still present. Page 7 the Aeromonas species isolated is
named caviae (I do not know if it likes caviar). Page 10, the medium used for
isolation is MacConkey agar.
The first sentence of the conclusion should be: This study has demonstrated
changes in Enterobacteriaceae (in the manuscript a "c" is lacking) diversity,
changes in E. coli phylogenetic groups and increases in.....
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Reduced diversity and increased virulence-gene carriage in intestinal
enterobacteria of coeliac children
Version: 3Date:1 October 2008
Reviewer: Christel Neut
Reviewer's report:
The manuscript is improved after revision. Some minor points need
consideration. In the introduction it should be clearly stated the previous results
of the same research group are already published. It should also be stated that in
the same individual, only one clone is usually predominant (as mentioned in the
author's response).
I agree that the analysis concerns a group of patients, but if only one clone is
analyzed from one patient and five from the others, the result for the group is not
homogenous, but this can be attenuated by the statement that usually only one
clone predominates in each individual.
Some spelling errors are still present. Page 7 the Aeromonas species isolated is
named caviae (I do not know if it likes caviar). Page 10, the medium used for
isolation is MacConkey agar.
The first sentence of the conclusion should be: This study has demonstrated
changes in Enterobacteriaceae (in the manuscript a "c" is lacking) diversity,
changes in E. coli phylogenetic groups and increases in.....
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant