Title: Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA
study
Version: 1 Date: 18 May 2021
Reviewer's report:
1. The study is not novel and doesn’t bring any significant new information to the knowledge
of the fatty liver disease. it is a retrospective longitudinal study. Interestingly, in all probability,
this same data was used in the publication of another manuscript earlier by the same authors
which highlighted the role of hyperglycemia being associated with AFLD. However, in this
manuscript, while citing the same reference (19), they mention that it was unclear whether AFLD
was a phenotype in metabolic syndrome. These two things appear contradictory and need to be
elaborated more.
2. The authors use ARLD and AFLD at the beginning of the manuscript. However, from the
definition of AFLD provide, it seems that both the acronyms are similar. Thus authors are
requested to explain if these two acronyms are different and are also suggested to stick to one
if not.
3. The authors, in the discussion section, mention that their data indicates overnutrition being an
important trigger for the development of liver steatosis in subjects consuming alcohol habitually.
However, in the baseline characteristics of the study population, the authors do not present any
parameter where they have monitored the nutrition/diet of these subjects over the period of the
study. Hence the claim about overnutrition pertaining to this study appears to be overanalyzing.
4. The discussion section is drafted well while the authors tried to provide a rational direction
to the outcome of this retrospective study. The authors are advised to include a working model
diagram/ infographic to summarize the metabolic pathways they talk about in the discussion.
Title: Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA
study
Version: 1 Date: 18 May 2021
Reviewer's report:
1. The study is not novel and doesn’t bring any significant new information to the knowledge
of the fatty liver disease. it is a retrospective longitudinal study. Interestingly, in all probability,
this same data was used in the publication of another manuscript earlier by the same authors
which highlighted the role of hyperglycemia being associated with AFLD. However, in this
manuscript, while citing the same reference (19), they mention that it was unclear whether AFLD
was a phenotype in metabolic syndrome. These two things appear contradictory and need to be
elaborated more.
2. The authors use ARLD and AFLD at the beginning of the manuscript. However, from the
definition of AFLD provide, it seems that both the acronyms are similar. Thus authors are
requested to explain if these two acronyms are different and are also suggested to stick to one
if not.
3. The authors, in the discussion section, mention that their data indicates overnutrition being an
important trigger for the development of liver steatosis in subjects consuming alcohol habitually.
However, in the baseline characteristics of the study population, the authors do not present any
parameter where they have monitored the nutrition/diet of these subjects over the period of the
study. Hence the claim about overnutrition pertaining to this study appears to be overanalyzing.
4. The discussion section is drafted well while the authors tried to provide a rational direction
to the outcome of this retrospective study. The authors are advised to include a working model
diagram/ infographic to summarize the metabolic pathways they talk about in the discussion.
Please review this paper.
user
Title: Obesity and metabolic abnormalities as risks of alcoholic fatty liver in men: NAGALA
study
Version: 1 Date: 18 May 2021
Reviewer's report:
1. The study is not novel and doesn’t bring any significant new information to the knowledge
of the fatty liver disease. it is a retrospective longitudinal study. Interestingly, in all probability,
this same data was used in the publication of another manuscript earlier by the same authors
which highlighted the role of hyperglycemia being associated with AFLD. However, in this
manuscript, while citing the same reference (19), they mention that it was unclear whether AFLD
was a phenotype in metabolic syndrome. These two things appear contradictory and need to be
elaborated more.
2. The authors use ARLD and AFLD at the beginning of the manuscript. However, from the
definition of AFLD provide, it seems that both the acronyms are similar. Thus authors are
requested to explain if these two acronyms are different and are also suggested to stick to one
if not.
3. The authors, in the discussion section, mention that their data indicates overnutrition being an
important trigger for the development of liver steatosis in subjects consuming alcohol habitually.
However, in the baseline characteristics of the study population, the authors do not present any
parameter where they have monitored the nutrition/diet of these subjects over the period of the
study. Hence the claim about overnutrition pertaining to this study appears to be overanalyzing.
4. The discussion section is drafted well while the authors tried to provide a rational direction
to the outcome of this retrospective study. The authors are advised to include a working model
diagram/ infographic to summarize the metabolic pathways they talk about in the discussion.
assistant