Title: Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for
identifying non-alcoholic fatty liver disease
Version: 2 Date: 24 Feb 2022
Reviewer's report:
This observational study aimed to explore the correlations between RC/HDL-C ratio NAFLD
risk. The main advantage of this study is a rather large sample size. Different multivariate models
were tested and RoC analysis was done. The study claims the RC/HDL-C index is a  potentially
useful marker for NAFLD risk. However, this statement should be taken with caution taking
into account the limitations acknowledged (absence of hepatic biopsy to confirm the diagnosis,
gender inequality, insulin resistance assessment, etc) by the authors.
It should be clarified to the readers that ROC analysis indicates the ability of the RC/HDL-C
index to discriminate healthy individuals from NAFLD patients, thus indicating the NAFLD
presence rather than the risk for developing NAFLD.  This statement should be corrected
throughout the manuscript, as risk assessment should be done by a different study protocol.
A prospective study on healthy individuals should be done to validate this claim and further
elucidate other findings of this study.
Title: Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for
identifying non-alcoholic fatty liver disease
Version: 2 Date: 24 Feb 2022
Reviewer's report:
This observational study aimed to explore the correlations between RC/HDL-C ratio NAFLD
risk. The main advantage of this study is a rather large sample size. Different multivariate models
were tested and RoC analysis was done. The study claims the RC/HDL-C index is a  potentially
useful marker for NAFLD risk. However, this statement should be taken with caution taking
into account the limitations acknowledged (absence of hepatic biopsy to confirm the diagnosis,
gender inequality, insulin resistance assessment, etc) by the authors.
It should be clarified to the readers that ROC analysis indicates the ability of the RC/HDL-C
index to discriminate healthy individuals from NAFLD patients, thus indicating the NAFLD
presence rather than the risk for developing NAFLD.  This statement should be corrected
throughout the manuscript, as risk assessment should be done by a different study protocol.
A prospective study on healthy individuals should be done to validate this claim and further
elucidate other findings of this study.
Please review this paper.
user
Title: Remnant cholesterol/high-density lipoprotein cholesterol ratio is a new powerful tool for
identifying non-alcoholic fatty liver disease
Version: 2 Date: 24 Feb 2022
Reviewer's report:
This observational study aimed to explore the correlations between RC/HDL-C ratio NAFLD
risk. The main advantage of this study is a rather large sample size. Different multivariate models
were tested and RoC analysis was done. The study claims the RC/HDL-C index is a  potentially
useful marker for NAFLD risk. However, this statement should be taken with caution taking
into account the limitations acknowledged (absence of hepatic biopsy to confirm the diagnosis,
gender inequality, insulin resistance assessment, etc) by the authors.
It should be clarified to the readers that ROC analysis indicates the ability of the RC/HDL-C
index to discriminate healthy individuals from NAFLD patients, thus indicating the NAFLD
presence rather than the risk for developing NAFLD.  This statement should be corrected
throughout the manuscript, as risk assessment should be done by a different study protocol.
A prospective study on healthy individuals should be done to validate this claim and further
elucidate other findings of this study.
assistant