Reviewer ’s report
Title: IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation.
Version: 0Date: 02 Feb 2018
Reviewer: Theodoros Androutsakos
Reviewer's report:A very interesting article, certainly worthwhile publishing. However it needs to be double-checked
when it comes to grammar since it contains a few grammar mistakes. The article's majordisadvantages are exactly what you say in the limitations' section. I would also suggest that sincecontinuos inflammation may lead to carcinogenesis in the liver, it would be interesting to add anHCC group apart from the cirrhosis and acute hepatitis groups. Moreover I would suggest to see ifthere is a correlation between HBV DNA and IFI16 in chronic HBV infected patients. Lastly Ihave a few questions about your article. First I wonder why HBV DNA in chronic HBV-infectedpatients is higher than Acute liver failure patients and second if there were any patients undertreatment in your chronic HBV-infected patients' group and if not why. Plus how long were thesepatients infected from HBV virus? Did that duration correlated with IFI16?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors' responses.I agree for my report to be made available under an Open Access Creative Commons CC-BYlicense (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I donot wish to be included in my named report can be included as confidential comments to theeditors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer ’s report
Title: IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation.
Version: 0Date: 02 Feb 2018
Reviewer: Theodoros Androutsakos
Reviewer's report:A very interesting article, certainly worthwhile publishing. However it needs to be double-checked
when it comes to grammar since it contains a few grammar mistakes. The article's majordisadvantages are exactly what you say in the limitations' section. I would also suggest that sincecontinuos inflammation may lead to carcinogenesis in the liver, it would be interesting to add anHCC group apart from the cirrhosis and acute hepatitis groups. Moreover I would suggest to see ifthere is a correlation between HBV DNA and IFI16 in chronic HBV infected patients. Lastly Ihave a few questions about your article. First I wonder why HBV DNA in chronic HBV-infectedpatients is higher than Acute liver failure patients and second if there were any patients undertreatment in your chronic HBV-infected patients' group and if not why. Plus how long were thesepatients infected from HBV virus? Did that duration correlated with IFI16?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors' responses.I agree for my report to be made available under an Open Access Creative Commons CC-BYlicense (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I donot wish to be included in my named report can be included as confidential comments to theeditors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer ’s report
Title: IFI16 is involved in HBV-associated acute-on-chronic liver failure inflammation.
Version: 0Date: 02 Feb 2018
Reviewer: Theodoros Androutsakos
Reviewer's report:A very interesting article, certainly worthwhile publishing. However it needs to be double-checked
when it comes to grammar since it contains a few grammar mistakes. The article's majordisadvantages are exactly what you say in the limitations' section. I would also suggest that sincecontinuos inflammation may lead to carcinogenesis in the liver, it would be interesting to add anHCC group apart from the cirrhosis and acute hepatitis groups. Moreover I would suggest to see ifthere is a correlation between HBV DNA and IFI16 in chronic HBV infected patients. Lastly Ihave a few questions about your article. First I wonder why HBV DNA in chronic HBV-infectedpatients is higher than Acute liver failure patients and second if there were any patients undertreatment in your chronic HBV-infected patients' group and if not why. Plus how long were thesepatients infected from HBV virus? Did that duration correlated with IFI16?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors' responses.I agree for my report to be made available under an Open Access Creative Commons CC-BYlicense (http://creativecommons.org/licenses/by/4.0/). I understand that any comments which I donot wish to be included in my named report can be included as confidential comments to theeditors, which will not be published.
I agree to the open peer review policy of the journal
assistant