Title: Manuscript Title: Comparative study on different endoscopic submucosal dissection
techniques for the treatment of superficial esophageal cancer and precancerous lesions
Version: 2 Date: 08 Dec 2024
Reviewer's report:
This study retrospectively evaluates the efficacy and safety of three endoscopic techniques—
endoscopic submucosal dissection (ESD), endoscopic submucosal tunneling dissection (ESTD),
and endoscopic submucosal dissection with C-shaped incision (ESD-C)—for the treatment of
superficial esophageal tumors. The findings suggest that ESD-C is a superior resection technique
compared to ESD and ESTD. This study is potentially novel, given the limited number of
prior publications directly comparing these three approaches. However, significant revisions are
required for this manuscript to meet the standards for publication in this journal.
1. Comparison Methodology:
The manuscript compares the outcomes of ESD, ESTD, and ESD-C in approximately 100
cases for each technique. To provide a robust comparison of their efficacy, a comprehensive
analysis of patient and lesion backgrounds across the three groups is essential. A propensity score
matching approach is recommended to adjust for potential confounding factors. For this purpose,
propensity scores can either be calculated and compared between two groups or generalized
propensity scores may be utilized to facilitate comparisons across all three groups.
2. Chronological Considerations:
The manuscript should clarify whether ESD, ESTD, and ESD-C were performed sequentially
or concurrently. Surgical expertise typically improves over time, and if ESD-C was performed
more recently, outcomes may reflect advances in procedural skill rather than intrinsic superiority
of the technique.
3. Terminology of Resection Outcomes:
The term "complete resection" is preferred over "curative resection" when referring to
procedures achieving negative resection margins, as it more accurately describes the technical
outcome of the resection.
Title: Manuscript Title: Comparative study on different endoscopic submucosal dissection
techniques for the treatment of superficial esophageal cancer and precancerous lesions
Version: 2 Date: 08 Dec 2024
Reviewer's report:
This study retrospectively evaluates the efficacy and safety of three endoscopic techniques—
endoscopic submucosal dissection (ESD), endoscopic submucosal tunneling dissection (ESTD),
and endoscopic submucosal dissection with C-shaped incision (ESD-C)—for the treatment of
superficial esophageal tumors. The findings suggest that ESD-C is a superior resection technique
compared to ESD and ESTD. This study is potentially novel, given the limited number of
prior publications directly comparing these three approaches. However, significant revisions are
required for this manuscript to meet the standards for publication in this journal.
1. Comparison Methodology:
The manuscript compares the outcomes of ESD, ESTD, and ESD-C in approximately 100
cases for each technique. To provide a robust comparison of their efficacy, a comprehensive
analysis of patient and lesion backgrounds across the three groups is essential. A propensity score
matching approach is recommended to adjust for potential confounding factors. For this purpose,
propensity scores can either be calculated and compared between two groups or generalized
propensity scores may be utilized to facilitate comparisons across all three groups.
2. Chronological Considerations:
The manuscript should clarify whether ESD, ESTD, and ESD-C were performed sequentially
or concurrently. Surgical expertise typically improves over time, and if ESD-C was performed
more recently, outcomes may reflect advances in procedural skill rather than intrinsic superiority
of the technique.
3. Terminology of Resection Outcomes:
The term "complete resection" is preferred over "curative resection" when referring to
procedures achieving negative resection margins, as it more accurately describes the technical
outcome of the resection.
Please review this paper.
user
Title: Manuscript Title: Comparative study on different endoscopic submucosal dissection
techniques for the treatment of superficial esophageal cancer and precancerous lesions
Version: 2 Date: 08 Dec 2024
Reviewer's report:
This study retrospectively evaluates the efficacy and safety of three endoscopic techniques—
endoscopic submucosal dissection (ESD), endoscopic submucosal tunneling dissection (ESTD),
and endoscopic submucosal dissection with C-shaped incision (ESD-C)—for the treatment of
superficial esophageal tumors. The findings suggest that ESD-C is a superior resection technique
compared to ESD and ESTD. This study is potentially novel, given the limited number of
prior publications directly comparing these three approaches. However, significant revisions are
required for this manuscript to meet the standards for publication in this journal.
1. Comparison Methodology:
The manuscript compares the outcomes of ESD, ESTD, and ESD-C in approximately 100
cases for each technique. To provide a robust comparison of their efficacy, a comprehensive
analysis of patient and lesion backgrounds across the three groups is essential. A propensity score
matching approach is recommended to adjust for potential confounding factors. For this purpose,
propensity scores can either be calculated and compared between two groups or generalized
propensity scores may be utilized to facilitate comparisons across all three groups.
2. Chronological Considerations:
The manuscript should clarify whether ESD, ESTD, and ESD-C were performed sequentially
or concurrently. Surgical expertise typically improves over time, and if ESD-C was performed
more recently, outcomes may reflect advances in procedural skill rather than intrinsic superiority
of the technique.
3. Terminology of Resection Outcomes:
The term "complete resection" is preferred over "curative resection" when referring to
procedures achieving negative resection margins, as it more accurately describes the technical
outcome of the resection.
assistant