Reviewer's report
Title:Therapeutic Effect of Intensive Granulocyte and Monocyte Adsorption
Apheresis Combined with Thiopurines for Steroid- and Biologics-Naive Japanese
Patients with Early-Diagnosed Crohn's Disease
Version:1Date:18 April 2014
Reviewer: Shingo Kato
Reviewer's report:
Major Compulsory Revisions
This manuscript has new evidences of GMAA- effects on early Crohn’s diseases.
GMAA with immunomodulators(IM) has strong therapeutic effects of early
induction of remission. It’s very interesting study. However, the authors should be
clear about some questions as follows;
1. Clinical remission rate of GMAA with IM (4 weeks) was 54% in figure 1. And
also authors mentioned approximately 60% of patients will have a complete
response during the short-term outcome (30 days) of a first course of steroids in
background. I agree the early remission-induction effect of GMAA with IM was
high. However, I think direct comparison between GMAA with IM and PSL with
IM for early Crohn’s disease.GMAA therapy will be needed next. How do the
authors think about this point? Because GMAA needs high cost.
2. The authors should describe about the definition of mucosal healing.
3. How did the authors determine the total numbers of GMAA sessions for each
patient?
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Reviewer's report
Title:Therapeutic Effect of Intensive Granulocyte and Monocyte Adsorption
Apheresis Combined with Thiopurines for Steroid- and Biologics-Naive Japanese
Patients with Early-Diagnosed Crohn's Disease
Version:1Date:18 April 2014
Reviewer: Shingo Kato
Reviewer's report:
Major Compulsory Revisions
This manuscript has new evidences of GMAA- effects on early Crohn’s diseases.
GMAA with immunomodulators(IM) has strong therapeutic effects of early
induction of remission. It’s very interesting study. However, the authors should be
clear about some questions as follows;
1. Clinical remission rate of GMAA with IM (4 weeks) was 54% in figure 1. And
also authors mentioned approximately 60% of patients will have a complete
response during the short-term outcome (30 days) of a first course of steroids in
background. I agree the early remission-induction effect of GMAA with IM was
high. However, I think direct comparison between GMAA with IM and PSL with
IM for early Crohn’s disease.GMAA therapy will be needed next. How do the
authors think about this point? Because GMAA needs high cost.
2. The authors should describe about the definition of mucosal healing.
3. How did the authors determine the total numbers of GMAA sessions for each
patient?
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Please review this paper.
user
Reviewer's report
Title:Therapeutic Effect of Intensive Granulocyte and Monocyte Adsorption
Apheresis Combined with Thiopurines for Steroid- and Biologics-Naive Japanese
Patients with Early-Diagnosed Crohn's Disease
Version:1Date:18 April 2014
Reviewer: Shingo Kato
Reviewer's report:
Major Compulsory Revisions
This manuscript has new evidences of GMAA- effects on early Crohn’s diseases.
GMAA with immunomodulators(IM) has strong therapeutic effects of early
induction of remission. It’s very interesting study. However, the authors should be
clear about some questions as follows;
1. Clinical remission rate of GMAA with IM (4 weeks) was 54% in figure 1. And
also authors mentioned approximately 60% of patients will have a complete
response during the short-term outcome (30 days) of a first course of steroids in
background. I agree the early remission-induction effect of GMAA with IM was
high. However, I think direct comparison between GMAA with IM and PSL with
IM for early Crohn’s disease.GMAA therapy will be needed next. How do the
authors think about this point? Because GMAA needs high cost.
2. The authors should describe about the definition of mucosal healing.
3. How did the authors determine the total numbers of GMAA sessions for each
patient?
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
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