Reviewer's report
Title:Candidiasis and other oral mucosal lesions during and after interferon
therapy for HCV-related chronic liver diseases
Version: 3Date:10 September 2012
Reviewer: Takafumi Saito
Reviewer's report:
Nagao et al. reported that oral candidiasis is associated with body weight loss
and hypoalbuminemia during IFN-based antiviral therapy in patients of chronic
hepatitis C.
Major points
1. They have drawn a conclusion from the results of the 14 patients who had
checkups for oral mucosal diseases throughout the regimen of IFN treatment.
The presence of oral candidiasis before IFN therapy seems to predict body
weight loss which is a serious adverse event of IFN, because 5 of 7 patients with
oral candidiasis had already it before IFN therapy. The reviewer recommends to
emphasize this important information in the text.
2. The statistical analysis of table 3 needs to be improved. Group A consists of
only 2 patients. There is no distribution of the variables, and the use mean +- SE
is not appropriate.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Candidiasis and other oral mucosal lesions during and after interferon
therapy for HCV-related chronic liver diseases
Version: 3Date:10 September 2012
Reviewer: Takafumi Saito
Reviewer's report:
Nagao et al. reported that oral candidiasis is associated with body weight loss
and hypoalbuminemia during IFN-based antiviral therapy in patients of chronic
hepatitis C.
Major points
1. They have drawn a conclusion from the results of the 14 patients who had
checkups for oral mucosal diseases throughout the regimen of IFN treatment.
The presence of oral candidiasis before IFN therapy seems to predict body
weight loss which is a serious adverse event of IFN, because 5 of 7 patients with
oral candidiasis had already it before IFN therapy. The reviewer recommends to
emphasize this important information in the text.
2. The statistical analysis of table 3 needs to be improved. Group A consists of
only 2 patients. There is no distribution of the variables, and the use mean +- SE
is not appropriate.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Candidiasis and other oral mucosal lesions during and after interferon
therapy for HCV-related chronic liver diseases
Version: 3Date:10 September 2012
Reviewer: Takafumi Saito
Reviewer's report:
Nagao et al. reported that oral candidiasis is associated with body weight loss
and hypoalbuminemia during IFN-based antiviral therapy in patients of chronic
hepatitis C.
Major points
1. They have drawn a conclusion from the results of the 14 patients who had
checkups for oral mucosal diseases throughout the regimen of IFN treatment.
The presence of oral candidiasis before IFN therapy seems to predict body
weight loss which is a serious adverse event of IFN, because 5 of 7 patients with
oral candidiasis had already it before IFN therapy. The reviewer recommends to
emphasize this important information in the text.
2. The statistical analysis of table 3 needs to be improved. Group A consists of
only 2 patients. There is no distribution of the variables, and the use mean +- SE
is not appropriate.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
assistant