Title: Gastric cancer risk after Helicobacter pylori eradication in gastritis and peptic ulcer: a
retrospective cohort study in Japan
Version: 1 Date: 28 Feb 2025
Reviewer's report:
This study examined the association between H. pylori-related atrophic gastritis, gastric ulcer,
and duodenal ulcer with the incidence of gastric cancer in patients who received H. pylori
eradication treatment. This relatively large cohort study confirmed previous findings that
patients with H. pylori-associated gastritis remain at an increased risk of gastric cancer, even
after eradication therapy.
Additionally, the authors evaluated the cumulative cancer risk in patients with H. pylori infection
who underwent eradication treatment. While the study relies on ICD coding for cohort selection,
which may introduce some bias, the large sample size strengthens the validity of the findings.
Few minor suggestions.
1. Please rewrite the results section in the abstract to include findings on cumulative cancer risk,
and shorten the methods section for conciseness.
2. Multiple comparisons among HPAG, GU, DU, and GDU may not be necessary. Consider
presenting only the key findings in the manuscript for better clarity.
Title: Gastric cancer risk after Helicobacter pylori eradication in gastritis and peptic ulcer: a
retrospective cohort study in Japan
Version: 1 Date: 28 Feb 2025
Reviewer's report:
This study examined the association between H. pylori-related atrophic gastritis, gastric ulcer,
and duodenal ulcer with the incidence of gastric cancer in patients who received H. pylori
eradication treatment. This relatively large cohort study confirmed previous findings that
patients with H. pylori-associated gastritis remain at an increased risk of gastric cancer, even
after eradication therapy.
Additionally, the authors evaluated the cumulative cancer risk in patients with H. pylori infection
who underwent eradication treatment. While the study relies on ICD coding for cohort selection,
which may introduce some bias, the large sample size strengthens the validity of the findings.
Few minor suggestions.
1. Please rewrite the results section in the abstract to include findings on cumulative cancer risk,
and shorten the methods section for conciseness.
2. Multiple comparisons among HPAG, GU, DU, and GDU may not be necessary. Consider
presenting only the key findings in the manuscript for better clarity.
Please review this paper.
user
Title: Gastric cancer risk after Helicobacter pylori eradication in gastritis and peptic ulcer: a
retrospective cohort study in Japan
Version: 1 Date: 28 Feb 2025
Reviewer's report:
This study examined the association between H. pylori-related atrophic gastritis, gastric ulcer,
and duodenal ulcer with the incidence of gastric cancer in patients who received H. pylori
eradication treatment. This relatively large cohort study confirmed previous findings that
patients with H. pylori-associated gastritis remain at an increased risk of gastric cancer, even
after eradication therapy.
Additionally, the authors evaluated the cumulative cancer risk in patients with H. pylori infection
who underwent eradication treatment. While the study relies on ICD coding for cohort selection,
which may introduce some bias, the large sample size strengthens the validity of the findings.
Few minor suggestions.
1. Please rewrite the results section in the abstract to include findings on cumulative cancer risk,
and shorten the methods section for conciseness.
2. Multiple comparisons among HPAG, GU, DU, and GDU may not be necessary. Consider
presenting only the key findings in the manuscript for better clarity.
assistant