Title: Quantitative splenic embolization possible-Application of 8Spheres conformal
microspheres in partial splenic embolization(PSE)
Version: 2 Date: 09 Oct 2021
Reviewer:  Nobuo Waguri
Reviewer's report:
More details have been added about the PSE method, especially the usage of microspheres. The
reason for injecting the embolic substance at the splenic hilum, consideration for blood vessels
going out of the spleen, and the injection method to prevent backflow were also described in
response to my request. But some concerns remain.
In Japan, even when used for embolization of liver tumors, it is usually diluted several tens of
times and injected so that microspheres do not aggregate.
At a dilution of about 2 to 8 times, agglomeration generally occurs considerably.
It's hard to believe that the 2-fold dilution does not result in microsphere aggregation.
Furthermore, it is hard to believe the authors' explanation that 179 cases of angiography did not
show the omentum branch that goes out of the spleen from inside the spleen.
However, the authors claim that, and further discussion is unproductive.
Title: Quantitative splenic embolization possible-Application of 8Spheres conformal
microspheres in partial splenic embolization(PSE)
Version: 2 Date: 09 Oct 2021
Reviewer:  Nobuo Waguri
Reviewer's report:
More details have been added about the PSE method, especially the usage of microspheres. The
reason for injecting the embolic substance at the splenic hilum, consideration for blood vessels
going out of the spleen, and the injection method to prevent backflow were also described in
response to my request. But some concerns remain.
In Japan, even when used for embolization of liver tumors, it is usually diluted several tens of
times and injected so that microspheres do not aggregate.
At a dilution of about 2 to 8 times, agglomeration generally occurs considerably.
It's hard to believe that the 2-fold dilution does not result in microsphere aggregation.
Furthermore, it is hard to believe the authors' explanation that 179 cases of angiography did not
show the omentum branch that goes out of the spleen from inside the spleen.
However, the authors claim that, and further discussion is unproductive.
Please review this paper.
user
Title: Quantitative splenic embolization possible-Application of 8Spheres conformal
microspheres in partial splenic embolization(PSE)
Version: 2 Date: 09 Oct 2021
Reviewer:  Nobuo Waguri
Reviewer's report:
More details have been added about the PSE method, especially the usage of microspheres. The
reason for injecting the embolic substance at the splenic hilum, consideration for blood vessels
going out of the spleen, and the injection method to prevent backflow were also described in
response to my request. But some concerns remain.
In Japan, even when used for embolization of liver tumors, it is usually diluted several tens of
times and injected so that microspheres do not aggregate.
At a dilution of about 2 to 8 times, agglomeration generally occurs considerably.
It's hard to believe that the 2-fold dilution does not result in microsphere aggregation.
Furthermore, it is hard to believe the authors' explanation that 179 cases of angiography did not
show the omentum branch that goes out of the spleen from inside the spleen.
However, the authors claim that, and further discussion is unproductive.
assistant