Title: Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer
and its predictive value
Version: 1 Date: 14 Jun 2023
Reviewer's report:
1. Please provide more information of how important of PLAC1 and Netrin-1 involved in cancer
metastasis in the introduction section.
2.Despite the statement in limitation, What is the potential mechanism of PLAC1 and Netrin-1
on liver metastasis in CRC patients?
3.The novelty and significance of the current study should be further emphasized.
4.1.1Inclusion criteria(1) All patients were definitely diagnosed as CRC by pathology. What is
pathology? Indicate the experiment or methodology. Also, (2) All patients diagnosed as liver
metastasis met the clinical diagnostic criteria. Specify what are the the clinical diagnostic criteria.
5.More detailed explanations should be reported in the results section.
Title: Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer
and its predictive value
Version: 1 Date: 14 Jun 2023
Reviewer's report:
1. Please provide more information of how important of PLAC1 and Netrin-1 involved in cancer
metastasis in the introduction section.
2.Despite the statement in limitation, What is the potential mechanism of PLAC1 and Netrin-1
on liver metastasis in CRC patients?
3.The novelty and significance of the current study should be further emphasized.
4.1.1Inclusion criteria(1) All patients were definitely diagnosed as CRC by pathology. What is
pathology? Indicate the experiment or methodology. Also, (2) All patients diagnosed as liver
metastasis met the clinical diagnostic criteria. Specify what are the the clinical diagnostic criteria.
5.More detailed explanations should be reported in the results section.
Please review this paper.
user
Title: Differential expression of PLAC1 and Netrin-1 in liver metastasis of colorectal cancer
and its predictive value
Version: 1 Date: 14 Jun 2023
Reviewer's report:
1. Please provide more information of how important of PLAC1 and Netrin-1 involved in cancer
metastasis in the introduction section.
2.Despite the statement in limitation, What is the potential mechanism of PLAC1 and Netrin-1
on liver metastasis in CRC patients?
3.The novelty and significance of the current study should be further emphasized.
4.1.1Inclusion criteria(1) All patients were definitely diagnosed as CRC by pathology. What is
pathology? Indicate the experiment or methodology. Also, (2) All patients diagnosed as liver
metastasis met the clinical diagnostic criteria. Specify what are the the clinical diagnostic criteria.
5.More detailed explanations should be reported in the results section.
assistant