Reviewer's report
Title:Rectal Forceps Biopsy Procedure in Cystic Fibrosis: Technical Aspects
and Patients Perspective for Clinical Trials Feasibility
Version: 3Date:5 February 2013
Reviewer: Martin Hug
Reviewer's report:
Minor Essential Revisions:
Despite the fact that the scope of the present work was NOT to compare forceps
with suction biopsies, the authors should at least mention that the values for
transepithelial resistance found in their study (14 - 21 Ohms x cm2) are
comparable with data found by others using similar (forceps) or even different
(suction) techniques (i.e. Bronsveld I et al. GASTROENTEROLOGY
2000;119:32–40: 27 Ohms x cm2, Hirtz s et al. GASTROENTEROLOGY
2004;127:1085–1095: 24 Ohms x cm2, van Barneveld et al. Biochimica et
Biophysica Acta 1802 (2010) 1062–1069: 24 - 39 Ohms x cm2 (no mean values
given).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Rectal Forceps Biopsy Procedure in Cystic Fibrosis: Technical Aspects
and Patients Perspective for Clinical Trials Feasibility
Version: 3Date:5 February 2013
Reviewer: Martin Hug
Reviewer's report:
Minor Essential Revisions:
Despite the fact that the scope of the present work was NOT to compare forceps
with suction biopsies, the authors should at least mention that the values for
transepithelial resistance found in their study (14 - 21 Ohms x cm2) are
comparable with data found by others using similar (forceps) or even different
(suction) techniques (i.e. Bronsveld I et al. GASTROENTEROLOGY
2000;119:32–40: 27 Ohms x cm2, Hirtz s et al. GASTROENTEROLOGY
2004;127:1085–1095: 24 Ohms x cm2, van Barneveld et al. Biochimica et
Biophysica Acta 1802 (2010) 1062–1069: 24 - 39 Ohms x cm2 (no mean values
given).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Rectal Forceps Biopsy Procedure in Cystic Fibrosis: Technical Aspects
and Patients Perspective for Clinical Trials Feasibility
Version: 3Date:5 February 2013
Reviewer: Martin Hug
Reviewer's report:
Minor Essential Revisions:
Despite the fact that the scope of the present work was NOT to compare forceps
with suction biopsies, the authors should at least mention that the values for
transepithelial resistance found in their study (14 - 21 Ohms x cm2) are
comparable with data found by others using similar (forceps) or even different
(suction) techniques (i.e. Bronsveld I et al. GASTROENTEROLOGY
2000;119:32–40: 27 Ohms x cm2, Hirtz s et al. GASTROENTEROLOGY
2004;127:1085–1095: 24 Ohms x cm2, van Barneveld et al. Biochimica et
Biophysica Acta 1802 (2010) 1062–1069: 24 - 39 Ohms x cm2 (no mean values
given).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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