Title: Two differentially methylated region (DMR) networks in nonalcoholic fatty liver disease,
viral hepatitis, and hepatocellular carcinoma
Version: 1 Date: 10 Apr 2022
Reviewer's report:
The study identified the NAFLD-specific DMR network 1 and DMR network 2, which was
present in NAFLD, viral hepatitis, and HCC. In addition, the study also determined that the
methylation levels of DMR network 2 changed cooperatively and/or synergistically during the
development of HCC. The above provide new insights into the pathogenesis of HCC, with
FABP1, SGK2, and HNF4A being candidate targets for the prevention and treatment of HCC.
This paper has good reference value and is recommended to be employed.
Title: Two differentially methylated region (DMR) networks in nonalcoholic fatty liver disease,
viral hepatitis, and hepatocellular carcinoma
Version: 1 Date: 10 Apr 2022
Reviewer's report:
The study identified the NAFLD-specific DMR network 1 and DMR network 2, which was
present in NAFLD, viral hepatitis, and HCC. In addition, the study also determined that the
methylation levels of DMR network 2 changed cooperatively and/or synergistically during the
development of HCC. The above provide new insights into the pathogenesis of HCC, with
FABP1, SGK2, and HNF4A being candidate targets for the prevention and treatment of HCC.
This paper has good reference value and is recommended to be employed.
Please review this paper.
user
Title: Two differentially methylated region (DMR) networks in nonalcoholic fatty liver disease,
viral hepatitis, and hepatocellular carcinoma
Version: 1 Date: 10 Apr 2022
Reviewer's report:
The study identified the NAFLD-specific DMR network 1 and DMR network 2, which was
present in NAFLD, viral hepatitis, and HCC. In addition, the study also determined that the
methylation levels of DMR network 2 changed cooperatively and/or synergistically during the
development of HCC. The above provide new insights into the pathogenesis of HCC, with
FABP1, SGK2, and HNF4A being candidate targets for the prevention and treatment of HCC.
This paper has good reference value and is recommended to be employed.
assistant