Title: IMMUNOHISTOCHEMISTRY AND REAL-TIME POLYMERASE CHAIN
REACTION: IMPORTANCE IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS IN
A PERUVIAN POPULATION
Version: 3 Date: 07 Jan 2024
Reviewer's report:
authors have highlighted the importance of IHC compared to standard diagnostic methods for
intestinal tuberculosis.
i have certain observations to make
1. Title: may be modified to be more representative of the aim of the study
2. Abstract : please avoid short forms in the abstract eg MTC
3. Introduction: The authors state that Intestinal TB is 6th most common Extra pulmonary site of
involvement but in the discussion, 1st line mentions it to be the most common. Please maintain
consistency and cite literature appropriately
authors may cite the latest review  for evidence-based diagnosis to intestinal tuberculosis DOI:
10.1007/s12664-023-01343-x
4. Methods: methodology follows a pattern in most scientific writing where subjects are
discussed first including study design, followed by procedure, then case definitions, ethics,
consent, and statistical analysis. authors should try to maintain that flow and add the missing
part. (authors may find this paper helpful in designing their manuscript PMID: 16120904  DOI:
10.2214/ajr.185.3.01850591)
5. Results: after demography primary finding of the study may be brought out which authors
aimed to analyse
did all patients undergo Upper GI endoscopy..if yes please mention in the methodology; if not
the stating duodenal involvement may be a misrepresentation
6. Discussion: 1st paragraph should discuss the primary finding of the study and the discussion
needs to be split into paragraphs meaningful. Authors may use the template as suggested above.
all the findings of the study need not be discussed. only important highlights and major changes
from previous studies needs to be discussed Eg IHC vs RT PCR, 75% AFB positivity on Biopsy
Title: IMMUNOHISTOCHEMISTRY AND REAL-TIME POLYMERASE CHAIN
REACTION: IMPORTANCE IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS IN
A PERUVIAN POPULATION
Version: 3 Date: 07 Jan 2024
Reviewer's report:
authors have highlighted the importance of IHC compared to standard diagnostic methods for
intestinal tuberculosis.
i have certain observations to make
1. Title: may be modified to be more representative of the aim of the study
2. Abstract : please avoid short forms in the abstract eg MTC
3. Introduction: The authors state that Intestinal TB is 6th most common Extra pulmonary site of
involvement but in the discussion, 1st line mentions it to be the most common. Please maintain
consistency and cite literature appropriately
authors may cite the latest review  for evidence-based diagnosis to intestinal tuberculosis DOI:
10.1007/s12664-023-01343-x
4. Methods: methodology follows a pattern in most scientific writing where subjects are
discussed first including study design, followed by procedure, then case definitions, ethics,
consent, and statistical analysis. authors should try to maintain that flow and add the missing
part. (authors may find this paper helpful in designing their manuscript PMID: 16120904  DOI:
10.2214/ajr.185.3.01850591)
5. Results: after demography primary finding of the study may be brought out which authors
aimed to analyse
did all patients undergo Upper GI endoscopy..if yes please mention in the methodology; if not
the stating duodenal involvement may be a misrepresentation
6. Discussion: 1st paragraph should discuss the primary finding of the study and the discussion
needs to be split into paragraphs meaningful. Authors may use the template as suggested above.
all the findings of the study need not be discussed. only important highlights and major changes
from previous studies needs to be discussed Eg IHC vs RT PCR, 75% AFB positivity on Biopsy
Please review this paper.
user
Title: IMMUNOHISTOCHEMISTRY AND REAL-TIME POLYMERASE CHAIN
REACTION: IMPORTANCE IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS IN
A PERUVIAN POPULATION
Version: 3 Date: 07 Jan 2024
Reviewer's report:
authors have highlighted the importance of IHC compared to standard diagnostic methods for
intestinal tuberculosis.
i have certain observations to make
1. Title: may be modified to be more representative of the aim of the study
2. Abstract : please avoid short forms in the abstract eg MTC
3. Introduction: The authors state that Intestinal TB is 6th most common Extra pulmonary site of
involvement but in the discussion, 1st line mentions it to be the most common. Please maintain
consistency and cite literature appropriately
authors may cite the latest review  for evidence-based diagnosis to intestinal tuberculosis DOI:
10.1007/s12664-023-01343-x
4. Methods: methodology follows a pattern in most scientific writing where subjects are
discussed first including study design, followed by procedure, then case definitions, ethics,
consent, and statistical analysis. authors should try to maintain that flow and add the missing
part. (authors may find this paper helpful in designing their manuscript PMID: 16120904  DOI:
10.2214/ajr.185.3.01850591)
5. Results: after demography primary finding of the study may be brought out which authors
aimed to analyse
did all patients undergo Upper GI endoscopy..if yes please mention in the methodology; if not
the stating duodenal involvement may be a misrepresentation
6. Discussion: 1st paragraph should discuss the primary finding of the study and the discussion
needs to be split into paragraphs meaningful. Authors may use the template as suggested above.
all the findings of the study need not be discussed. only important highlights and major changes
from previous studies needs to be discussed Eg IHC vs RT PCR, 75% AFB positivity on Biopsy
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