Title: MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells
Version: 0 Date: 03 Oct 2021
Reviewer:  Nijiro Nohata
Reviewer's report:
The results of the authors' analysis, namely that miR-1-3p plays a tumor suppressor role in
gastric cancer by negatively regulating oncogenic CENPF, are generally reliable and convincing.
However, such analysis and findings have already been demonstrated in many cancer types,
and are not particularly new or interesting molecular mechanisms. I would like to request the
following minor revisions to make this analysis more thoughtful.
1) Describe the expression status and role of miR-1-5p in gastric cancer.
2) Describe the miRNAs other than miR-1-3p that are regulated by CENPF, including other
carcinomas.
3) Provide additional analysis or insight into the genetic or epigenetic causes of decreased
expression of miR-1-3p or increased expression of CENPF in gastric cancer.
Title: MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells
Version: 0 Date: 03 Oct 2021
Reviewer:  Nijiro Nohata
Reviewer's report:
The results of the authors' analysis, namely that miR-1-3p plays a tumor suppressor role in
gastric cancer by negatively regulating oncogenic CENPF, are generally reliable and convincing.
However, such analysis and findings have already been demonstrated in many cancer types,
and are not particularly new or interesting molecular mechanisms. I would like to request the
following minor revisions to make this analysis more thoughtful.
1) Describe the expression status and role of miR-1-5p in gastric cancer.
2) Describe the miRNAs other than miR-1-3p that are regulated by CENPF, including other
carcinomas.
3) Provide additional analysis or insight into the genetic or epigenetic causes of decreased
expression of miR-1-3p or increased expression of CENPF in gastric cancer.
Please review this paper.
user
Title: MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells
Version: 0 Date: 03 Oct 2021
Reviewer:  Nijiro Nohata
Reviewer's report:
The results of the authors' analysis, namely that miR-1-3p plays a tumor suppressor role in
gastric cancer by negatively regulating oncogenic CENPF, are generally reliable and convincing.
However, such analysis and findings have already been demonstrated in many cancer types,
and are not particularly new or interesting molecular mechanisms. I would like to request the
following minor revisions to make this analysis more thoughtful.
1) Describe the expression status and role of miR-1-5p in gastric cancer.
2) Describe the miRNAs other than miR-1-3p that are regulated by CENPF, including other
carcinomas.
3) Provide additional analysis or insight into the genetic or epigenetic causes of decreased
expression of miR-1-3p or increased expression of CENPF in gastric cancer.
assistant