Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 0 Date: 15 Jul 2024
Reviewer's report:
Zhang et al. evaluated associations of LE8 with prognosis of ALD. Recent SLD definition
of ALD is based on hepatic steatosis and AC>6 drinks per day for men and >5
drinks per day for women, regardless of the presence of cardiometabolic risk factors.
Please consider modifying the whole manuscript according to the recent definition (https://
pubmed.ncbi.nlm.nih.gov/37364790/). Stratifying the LE8 according to the subcategory to
evaluate which component of the LE8 has contributed mostly to mortality would be interesting.
In addition, the word "prognosis" is seems not appropriate in this study. Please consider changing
it to mortality. There are some recent studies that evaluated associations of SLD subtypes,
including ALD, with the risk of CVD. The discussion needs more information on the risk of
CVD or mortality in patients with ALD.
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 0 Date: 15 Jul 2024
Reviewer's report:
Zhang et al. evaluated associations of LE8 with prognosis of ALD. Recent SLD definition
of ALD is based on hepatic steatosis and AC>6 drinks per day for men and >5
drinks per day for women, regardless of the presence of cardiometabolic risk factors.
Please consider modifying the whole manuscript according to the recent definition (https://
pubmed.ncbi.nlm.nih.gov/37364790/). Stratifying the LE8 according to the subcategory to
evaluate which component of the LE8 has contributed mostly to mortality would be interesting.
In addition, the word "prognosis" is seems not appropriate in this study. Please consider changing
it to mortality. There are some recent studies that evaluated associations of SLD subtypes,
including ALD, with the risk of CVD. The discussion needs more information on the risk of
CVD or mortality in patients with ALD.
Please review this paper.
user
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 0 Date: 15 Jul 2024
Reviewer's report:
Zhang et al. evaluated associations of LE8 with prognosis of ALD. Recent SLD definition
of ALD is based on hepatic steatosis and AC>6 drinks per day for men and >5
drinks per day for women, regardless of the presence of cardiometabolic risk factors.
Please consider modifying the whole manuscript according to the recent definition (https://
pubmed.ncbi.nlm.nih.gov/37364790/). Stratifying the LE8 according to the subcategory to
evaluate which component of the LE8 has contributed mostly to mortality would be interesting.
In addition, the word "prognosis" is seems not appropriate in this study. Please consider changing
it to mortality. There are some recent studies that evaluated associations of SLD subtypes,
including ALD, with the risk of CVD. The discussion needs more information on the risk of
CVD or mortality in patients with ALD.
assistant