Reviewer's report
Title:Physiologic and Laboratory Correlates of Depression, Anxiety, and Poor
Sleep in Liver Cirrhosis
Version: 2Date:8 August 2012
Reviewer: Charmaine Stewart
Reviewer's report:
The aims of the study were not well stated.
The clinical relevance has not been demonstrated by the study.
Major Revisions: Please identify the questions that are being addressed by this
study and the end-points. Better defined population, were these patients
hospitalized or were they inpatients; did they have renal insufficency?
The authors found ST elevation to be significantly correlated with HAMD and
PSQI scores and concluded that AST was a marker of direct liver damage and
psychological stress. This conclusion is difficult to reach with such limited data.
Furthermore, the patients with Child class C had significantly higher bilirubin
levels raising the possibility of acute on chronic liver disease, a stressful
physiological state that could result in more profound hyperdynamic circulation
and hence a higher heart rate.
The clinical relevance of the findings are minimal.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:Physiologic and Laboratory Correlates of Depression, Anxiety, and Poor
Sleep in Liver Cirrhosis
Version: 2Date:8 August 2012
Reviewer: Charmaine Stewart
Reviewer's report:
The aims of the study were not well stated.
The clinical relevance has not been demonstrated by the study.
Major Revisions: Please identify the questions that are being addressed by this
study and the end-points. Better defined population, were these patients
hospitalized or were they inpatients; did they have renal insufficency?
The authors found ST elevation to be significantly correlated with HAMD and
PSQI scores and concluded that AST was a marker of direct liver damage and
psychological stress. This conclusion is difficult to reach with such limited data.
Furthermore, the patients with Child class C had significantly higher bilirubin
levels raising the possibility of acute on chronic liver disease, a stressful
physiological state that could result in more profound hyperdynamic circulation
and hence a higher heart rate.
The clinical relevance of the findings are minimal.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:Physiologic and Laboratory Correlates of Depression, Anxiety, and Poor
Sleep in Liver Cirrhosis
Version: 2Date:8 August 2012
Reviewer: Charmaine Stewart
Reviewer's report:
The aims of the study were not well stated.
The clinical relevance has not been demonstrated by the study.
Major Revisions: Please identify the questions that are being addressed by this
study and the end-points. Better defined population, were these patients
hospitalized or were they inpatients; did they have renal insufficency?
The authors found ST elevation to be significantly correlated with HAMD and
PSQI scores and concluded that AST was a marker of direct liver damage and
psychological stress. This conclusion is difficult to reach with such limited data.
Furthermore, the patients with Child class C had significantly higher bilirubin
levels raising the possibility of acute on chronic liver disease, a stressful
physiological state that could result in more profound hyperdynamic circulation
and hence a higher heart rate.
The clinical relevance of the findings are minimal.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant