Title: Simultaneous detection of Helicobacter pylori infection comparing between white light
and image-enhanced endoscopy
Version: 2 Date: 03 Jan 2024
Reviewer:  Masao Kobayakawa
Reviewer's report:
1. To prevent misunderstanding or confusion, the followings are recommended.
1) In the manuscript and Table 3 and Figure3, “magnifying NBI” or “magnifying BLI”, instead
of NBI or BLI, should be described as endoscopic diagnostic method of H. pylori infection using
magnifying method.
2) In the manuscript and Table 3, “Comprehensive findings on LCI” and “Comprehensive
findings on WLI” should be described as endoscopic diagnostic method of H. pylori infection
based on the presence of at least 1 of 8 findings according to Kyoto classification. Furthermore,
this explanation should be shown in the annotation of Table 3.
3)  Each finding indicative or non-indicative H. pylori infection should be described as XXX on
XXX, for example, diffuse redness on LCI or each finding on WLI.
2. Only sensitivity of the finding on magnifying BLI was significantly higher than that of
comprehensive findings on WLI, so that it is inappropriate to say that IEE significantly improved
real-time endoscopic diagnosis of H. pylori infection compared with WLI in the conclusions
of the Abstract and the Manuscript. Instead, precisely based on the result, the authors should
conclude that the sensitivity of enlarged or elongated pits with obscure SECNs or dense fine
irregular vessels on magnifying BLI was significantly higher for H. pylori infection status
compared with comprehensive findings on WLI.
Title: Simultaneous detection of Helicobacter pylori infection comparing between white light
and image-enhanced endoscopy
Version: 2 Date: 03 Jan 2024
Reviewer:  Masao Kobayakawa
Reviewer's report:
1. To prevent misunderstanding or confusion, the followings are recommended.
1) In the manuscript and Table 3 and Figure3, “magnifying NBI” or “magnifying BLI”, instead
of NBI or BLI, should be described as endoscopic diagnostic method of H. pylori infection using
magnifying method.
2) In the manuscript and Table 3, “Comprehensive findings on LCI” and “Comprehensive
findings on WLI” should be described as endoscopic diagnostic method of H. pylori infection
based on the presence of at least 1 of 8 findings according to Kyoto classification. Furthermore,
this explanation should be shown in the annotation of Table 3.
3)  Each finding indicative or non-indicative H. pylori infection should be described as XXX on
XXX, for example, diffuse redness on LCI or each finding on WLI.
2. Only sensitivity of the finding on magnifying BLI was significantly higher than that of
comprehensive findings on WLI, so that it is inappropriate to say that IEE significantly improved
real-time endoscopic diagnosis of H. pylori infection compared with WLI in the conclusions
of the Abstract and the Manuscript. Instead, precisely based on the result, the authors should
conclude that the sensitivity of enlarged or elongated pits with obscure SECNs or dense fine
irregular vessels on magnifying BLI was significantly higher for H. pylori infection status
compared with comprehensive findings on WLI.
Please review this paper.
user
Title: Simultaneous detection of Helicobacter pylori infection comparing between white light
and image-enhanced endoscopy
Version: 2 Date: 03 Jan 2024
Reviewer:  Masao Kobayakawa
Reviewer's report:
1. To prevent misunderstanding or confusion, the followings are recommended.
1) In the manuscript and Table 3 and Figure3, “magnifying NBI” or “magnifying BLI”, instead
of NBI or BLI, should be described as endoscopic diagnostic method of H. pylori infection using
magnifying method.
2) In the manuscript and Table 3, “Comprehensive findings on LCI” and “Comprehensive
findings on WLI” should be described as endoscopic diagnostic method of H. pylori infection
based on the presence of at least 1 of 8 findings according to Kyoto classification. Furthermore,
this explanation should be shown in the annotation of Table 3.
3)  Each finding indicative or non-indicative H. pylori infection should be described as XXX on
XXX, for example, diffuse redness on LCI or each finding on WLI.
2. Only sensitivity of the finding on magnifying BLI was significantly higher than that of
comprehensive findings on WLI, so that it is inappropriate to say that IEE significantly improved
real-time endoscopic diagnosis of H. pylori infection compared with WLI in the conclusions
of the Abstract and the Manuscript. Instead, precisely based on the result, the authors should
conclude that the sensitivity of enlarged or elongated pits with obscure SECNs or dense fine
irregular vessels on magnifying BLI was significantly higher for H. pylori infection status
compared with comprehensive findings on WLI.
assistant