Reviewer's report
Title:Clinicopathologic characteristics and treatment outcomes of hepatoid
adenocarcinoma of stomach, a rare but unique subtype of gastric cancer
Version: 1Date:21 January 2011
Reviewer: Rosario Caruso
Reviewer's report:
In this study, the authors have evaluated clinicopathologic characteristics,
treatment, outcome, and prognosis in patients with gastric hepatoid carcinomas.
The authors performe a computer search of pathology report to identify hepatoid
adenocarcinoma of the stomach. In particular, pathologic data included
histopathological characteristics such as differentiation, Laurèn classification,
immunohistochemical staining and serum AFP.
There are critical points that need clarification.
1)Although it is stated both in the Introduction and in Discussion that hepatoid
adenocarcinoma has been considered as a specific entity diagnosed by
histological features that resemble hepatocellular carcinoma, regardless of AFP
production, this is not made clear in the immunohistochemical part of Methods
and Results sections. In other words, what were the diagnostic criteria used to
define an hepatoid adenocarcinoma of the stomach?
2)In the Results, the authors report that there were nine patients with intestinal
type, five with mixed type and four with diffuse type. Usually, hepatoid
adenocarcinomas have the histological and immunohistochemical of both liver
cell carcinoma and conventional intestinal-type adenocarcinoma. The authors
should provide morphological and immunohistochemical documentation on four
tumors that are described in the text as diffuse carcinomas. Furthermore,
morphologic characteristics are not established in 8 out of 26 cases according to
Laurèn classification , as revealed in table 1.
3) The Methods section can benefit from a better description of the antisera used
for differential diagnosis of hepatoid adenocarcinoma.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Clinicopathologic characteristics and treatment outcomes of hepatoid
adenocarcinoma of stomach, a rare but unique subtype of gastric cancer
Version: 1Date:21 January 2011
Reviewer: Rosario Caruso
Reviewer's report:
In this study, the authors have evaluated clinicopathologic characteristics,
treatment, outcome, and prognosis in patients with gastric hepatoid carcinomas.
The authors performe a computer search of pathology report to identify hepatoid
adenocarcinoma of the stomach. In particular, pathologic data included
histopathological characteristics such as differentiation, Laurèn classification,
immunohistochemical staining and serum AFP.
There are critical points that need clarification.
1)Although it is stated both in the Introduction and in Discussion that hepatoid
adenocarcinoma has been considered as a specific entity diagnosed by
histological features that resemble hepatocellular carcinoma, regardless of AFP
production, this is not made clear in the immunohistochemical part of Methods
and Results sections. In other words, what were the diagnostic criteria used to
define an hepatoid adenocarcinoma of the stomach?
2)In the Results, the authors report that there were nine patients with intestinal
type, five with mixed type and four with diffuse type. Usually, hepatoid
adenocarcinomas have the histological and immunohistochemical of both liver
cell carcinoma and conventional intestinal-type adenocarcinoma. The authors
should provide morphological and immunohistochemical documentation on four
tumors that are described in the text as diffuse carcinomas. Furthermore,
morphologic characteristics are not established in 8 out of 26 cases according to
Laurèn classification , as revealed in table 1.
3) The Methods section can benefit from a better description of the antisera used
for differential diagnosis of hepatoid adenocarcinoma.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Clinicopathologic characteristics and treatment outcomes of hepatoid
adenocarcinoma of stomach, a rare but unique subtype of gastric cancer
Version: 1Date:21 January 2011
Reviewer: Rosario Caruso
Reviewer's report:
In this study, the authors have evaluated clinicopathologic characteristics,
treatment, outcome, and prognosis in patients with gastric hepatoid carcinomas.
The authors performe a computer search of pathology report to identify hepatoid
adenocarcinoma of the stomach. In particular, pathologic data included
histopathological characteristics such as differentiation, Laurèn classification,
immunohistochemical staining and serum AFP.
There are critical points that need clarification.
1)Although it is stated both in the Introduction and in Discussion that hepatoid
adenocarcinoma has been considered as a specific entity diagnosed by
histological features that resemble hepatocellular carcinoma, regardless of AFP
production, this is not made clear in the immunohistochemical part of Methods
and Results sections. In other words, what were the diagnostic criteria used to
define an hepatoid adenocarcinoma of the stomach?
2)In the Results, the authors report that there were nine patients with intestinal
type, five with mixed type and four with diffuse type. Usually, hepatoid
adenocarcinomas have the histological and immunohistochemical of both liver
cell carcinoma and conventional intestinal-type adenocarcinoma. The authors
should provide morphological and immunohistochemical documentation on four
tumors that are described in the text as diffuse carcinomas. Furthermore,
morphologic characteristics are not established in 8 out of 26 cases according to
Laurèn classification , as revealed in table 1.
3) The Methods section can benefit from a better description of the antisera used
for differential diagnosis of hepatoid adenocarcinoma.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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