Reviewer's report
Title:Synchronous Appendiceal and Intramucosal Gastric Signet Ring Cell
Carcinomas in an Individual with CDH1-associated Hereditary Diffuse Gastric
Carcinoma: a Case Report of a Novel Association and Review of the Literature
Version: 1Date:18 May 2013
Reviewer: Adedayo A Onitilo
Reviewer's report:
This is a well written paper and highlight novel presentation of a synchronous
appendiceal and intramucosal gastric signet ring cell carcinomas in an Individual
with CDH1-associated Hereditary Diffuse Gastric Carcinoma.
I have no major concern with the paper.
Minor suggestion:
1) Consider shortening the background and case report section.
2) Consider adding a pedigree diagram (family tree) showing affected and
unaffected individuals
3) Consider adding to the case presentation section what prompted the thought
for genetic screening 6 years after breast cancer diagnosis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Synchronous Appendiceal and Intramucosal Gastric Signet Ring Cell
Carcinomas in an Individual with CDH1-associated Hereditary Diffuse Gastric
Carcinoma: a Case Report of a Novel Association and Review of the Literature
Version: 1Date:18 May 2013
Reviewer: Adedayo A Onitilo
Reviewer's report:
This is a well written paper and highlight novel presentation of a synchronous
appendiceal and intramucosal gastric signet ring cell carcinomas in an Individual
with CDH1-associated Hereditary Diffuse Gastric Carcinoma.
I have no major concern with the paper.
Minor suggestion:
1) Consider shortening the background and case report section.
2) Consider adding a pedigree diagram (family tree) showing affected and
unaffected individuals
3) Consider adding to the case presentation section what prompted the thought
for genetic screening 6 years after breast cancer diagnosis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Synchronous Appendiceal and Intramucosal Gastric Signet Ring Cell
Carcinomas in an Individual with CDH1-associated Hereditary Diffuse Gastric
Carcinoma: a Case Report of a Novel Association and Review of the Literature
Version: 1Date:18 May 2013
Reviewer: Adedayo A Onitilo
Reviewer's report:
This is a well written paper and highlight novel presentation of a synchronous
appendiceal and intramucosal gastric signet ring cell carcinomas in an Individual
with CDH1-associated Hereditary Diffuse Gastric Carcinoma.
I have no major concern with the paper.
Minor suggestion:
1) Consider shortening the background and case report section.
2) Consider adding a pedigree diagram (family tree) showing affected and
unaffected individuals
3) Consider adding to the case presentation section what prompted the thought
for genetic screening 6 years after breast cancer diagnosis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant