Reviewer's report
Title:Oral versus intravenous proton pump inhibitors in preventing re-bleeding
for patients with peptic ulcer bleeding after successful endoscopic therapy
Version: 2Date:1 April 2012
Reviewer: Chen-Wang Chang Chang
Reviewer's report:
Although the study was interesting, the following points needs to be further
clarified:
1. As the author mentioned, the study was not powered to prove equivalence or
non-inferiority of IV and oral PPI. The authors must enrol more case.
2. In the study design, enrolled patients were randomly allocated into two groups
patients, either IV esomeprazole or oral lansoprazole. In my opinion,
esomeprazole and lansoprazole are not the same medicine. To compare the oral
and IV form esomeprazole may be better.
3. Patients with oral PPIs have a shorter hospital stay. I think this finding is not
adequate due to bias in the study design. In my opinion, the difference of cost in
this study is more worth.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Oral versus intravenous proton pump inhibitors in preventing re-bleeding
for patients with peptic ulcer bleeding after successful endoscopic therapy
Version: 2Date:1 April 2012
Reviewer: Chen-Wang Chang Chang
Reviewer's report:
Although the study was interesting, the following points needs to be further
clarified:
1. As the author mentioned, the study was not powered to prove equivalence or
non-inferiority of IV and oral PPI. The authors must enrol more case.
2. In the study design, enrolled patients were randomly allocated into two groups
patients, either IV esomeprazole or oral lansoprazole. In my opinion,
esomeprazole and lansoprazole are not the same medicine. To compare the oral
and IV form esomeprazole may be better.
3. Patients with oral PPIs have a shorter hospital stay. I think this finding is not
adequate due to bias in the study design. In my opinion, the difference of cost in
this study is more worth.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Oral versus intravenous proton pump inhibitors in preventing re-bleeding
for patients with peptic ulcer bleeding after successful endoscopic therapy
Version: 2Date:1 April 2012
Reviewer: Chen-Wang Chang Chang
Reviewer's report:
Although the study was interesting, the following points needs to be further
clarified:
1. As the author mentioned, the study was not powered to prove equivalence or
non-inferiority of IV and oral PPI. The authors must enrol more case.
2. In the study design, enrolled patients were randomly allocated into two groups
patients, either IV esomeprazole or oral lansoprazole. In my opinion,
esomeprazole and lansoprazole are not the same medicine. To compare the oral
and IV form esomeprazole may be better.
3. Patients with oral PPIs have a shorter hospital stay. I think this finding is not
adequate due to bias in the study design. In my opinion, the difference of cost in
this study is more worth.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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