Title: Association between the development of sepsis and the triglyceride-glucose index in acute
pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database
Version: 1 Date: 11 Jan 2025
Reviewer's report:
I find this manuscript particularly interesting, especially due to its use of the Boruta algorithm for
selecting relevant variables. I recommend accepting the manuscript for publication, contingent
upon the authors addressing minor revisions:
1) In the Introduction, second paragraph, the author states: "Changes in blood glucose and lipid
levels during the pathophysiological process of acute pancreatitis and their impact on patient
outcomes have received widespread attention." While the cited references primarily address the
relationship between diabetes mellitus and pancreatitis, it would strengthen the manuscript to
include additional recent studies exploring the impact of  hypertriglyceridemia by itself on the
outcomes of acute pancreatitis. This is particularly relevant, as patients with dyslipidemia—
despite not being diabetic—have been associated with worse clinical outcomes.
2) What was the optimal cutoff point of the TyG index to predict sepsis in your study, and which
method did you use to determine it?
Title: Association between the development of sepsis and the triglyceride-glucose index in acute
pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database
Version: 1 Date: 11 Jan 2025
Reviewer's report:
I find this manuscript particularly interesting, especially due to its use of the Boruta algorithm for
selecting relevant variables. I recommend accepting the manuscript for publication, contingent
upon the authors addressing minor revisions:
1) In the Introduction, second paragraph, the author states: "Changes in blood glucose and lipid
levels during the pathophysiological process of acute pancreatitis and their impact on patient
outcomes have received widespread attention." While the cited references primarily address the
relationship between diabetes mellitus and pancreatitis, it would strengthen the manuscript to
include additional recent studies exploring the impact of  hypertriglyceridemia by itself on the
outcomes of acute pancreatitis. This is particularly relevant, as patients with dyslipidemia—
despite not being diabetic—have been associated with worse clinical outcomes.
2) What was the optimal cutoff point of the TyG index to predict sepsis in your study, and which
method did you use to determine it?
Please review this paper.
user
Title: Association between the development of sepsis and the triglyceride-glucose index in acute
pancreatitis patients: a retrospective investigation utilizing the MIMIC-IV database
Version: 1 Date: 11 Jan 2025
Reviewer's report:
I find this manuscript particularly interesting, especially due to its use of the Boruta algorithm for
selecting relevant variables. I recommend accepting the manuscript for publication, contingent
upon the authors addressing minor revisions:
1) In the Introduction, second paragraph, the author states: "Changes in blood glucose and lipid
levels during the pathophysiological process of acute pancreatitis and their impact on patient
outcomes have received widespread attention." While the cited references primarily address the
relationship between diabetes mellitus and pancreatitis, it would strengthen the manuscript to
include additional recent studies exploring the impact of  hypertriglyceridemia by itself on the
outcomes of acute pancreatitis. This is particularly relevant, as patients with dyslipidemia—
despite not being diabetic—have been associated with worse clinical outcomes.
2) What was the optimal cutoff point of the TyG index to predict sepsis in your study, and which
method did you use to determine it?
assistant