Title: Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening:
a meta-analysis
Version: 3 Date: 15 Jun 2022
Reviewer's report:
In this meta-analysis, the authors aimed to estimate the diagnostic performance of methylated
sindecan2 as a potential biomarker to screen for colorectal cancer.  They found that SDC2 could
be a useful biomarker for CRC, and for precancerous adenomas.
The revised version of the manuscript is correct, the authors answer the questions of the previous
reviewers. The changes they made improved the quality of the review.  They discuss their results
in a moderate way, also the results are critically evaluated. I suggest accepting the manuscript
for publication.
Title: Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening:
a meta-analysis
Version: 3 Date: 15 Jun 2022
Reviewer's report:
In this meta-analysis, the authors aimed to estimate the diagnostic performance of methylated
sindecan2 as a potential biomarker to screen for colorectal cancer.  They found that SDC2 could
be a useful biomarker for CRC, and for precancerous adenomas.
The revised version of the manuscript is correct, the authors answer the questions of the previous
reviewers. The changes they made improved the quality of the review.  They discuss their results
in a moderate way, also the results are critically evaluated. I suggest accepting the manuscript
for publication.
Please review this paper.
user
Title: Diagnostic accuracy of DNA-based SDC2 methylation test in colorectal cancer screening:
a meta-analysis
Version: 3 Date: 15 Jun 2022
Reviewer's report:
In this meta-analysis, the authors aimed to estimate the diagnostic performance of methylated
sindecan2 as a potential biomarker to screen for colorectal cancer.  They found that SDC2 could
be a useful biomarker for CRC, and for precancerous adenomas.
The revised version of the manuscript is correct, the authors answer the questions of the previous
reviewers. The changes they made improved the quality of the review.  They discuss their results
in a moderate way, also the results are critically evaluated. I suggest accepting the manuscript
for publication.
assistant