Reviewer's report
Title:Clinical relevance of the cagA, tnpA and tnpB genes in Helicobacter pylori
Version: 1Date:28 August 2013
Reviewer: Marino Venerito
Reviewer's report:
In their manuscript the authors report a small but statistically significant increased
risk to develop gastric cancer for subjects with H. pylori infection that are positive
for the transposase tnpA detected by PCR. The presence of the transposase
tnpB was not associated with an increased risk for developing gastric cancer.
Major comments:
1. Please, add statistical facts (OR, 95% CI) in the “abstract” section.
2. In the section “materials and methods” authors report that the selection
criterion for endoscopic examination was the suspicion for an H. pylori infection
whereas in the section “discussion” it is stated that included subjects had
dyspeptic symptoms. Could please the authors better clarify the indication for
endoscopic investigation in their patients?
Minor comment:
Page 3, line 53 the “k” of NF-kB is not correctly visualised.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Clinical relevance of the cagA, tnpA and tnpB genes in Helicobacter pylori
Version: 1Date:28 August 2013
Reviewer: Marino Venerito
Reviewer's report:
In their manuscript the authors report a small but statistically significant increased
risk to develop gastric cancer for subjects with H. pylori infection that are positive
for the transposase tnpA detected by PCR. The presence of the transposase
tnpB was not associated with an increased risk for developing gastric cancer.
Major comments:
1. Please, add statistical facts (OR, 95% CI) in the “abstract” section.
2. In the section “materials and methods” authors report that the selection
criterion for endoscopic examination was the suspicion for an H. pylori infection
whereas in the section “discussion” it is stated that included subjects had
dyspeptic symptoms. Could please the authors better clarify the indication for
endoscopic investigation in their patients?
Minor comment:
Page 3, line 53 the “k” of NF-kB is not correctly visualised.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Clinical relevance of the cagA, tnpA and tnpB genes in Helicobacter pylori
Version: 1Date:28 August 2013
Reviewer: Marino Venerito
Reviewer's report:
In their manuscript the authors report a small but statistically significant increased
risk to develop gastric cancer for subjects with H. pylori infection that are positive
for the transposase tnpA detected by PCR. The presence of the transposase
tnpB was not associated with an increased risk for developing gastric cancer.
Major comments:
1. Please, add statistical facts (OR, 95% CI) in the “abstract” section.
2. In the section “materials and methods” authors report that the selection
criterion for endoscopic examination was the suspicion for an H. pylori infection
whereas in the section “discussion” it is stated that included subjects had
dyspeptic symptoms. Could please the authors better clarify the indication for
endoscopic investigation in their patients?
Minor comment:
Page 3, line 53 the “k” of NF-kB is not correctly visualised.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant