Reviewer’ s report
Title: Association between NAFLD and risk of prevalent chronic kidney disease: Why there is a
difference between East and West?
Version: 0Date: 07 Feb 2020
Reviewer: Rosa Filiberti
Reviewer's report:
The authors used datasets from a Western and a Eastern population to clarify the association
between NAFLD and CKD. They concluded that NAFLD increases the risk of early stages CKDin both populations, while a significant association was found only for Chinese people whenconsidering all stages of CKD.I think that the use of different non standardized datasets, mainlythe difference in the considered period (1984 to 1994 for China and 2010 for USA) may haveinfluenced results. The authors should discuss better the limits of the study given also the fact thatthey compared two populations with large differences in lyfestile and dietary habits (see forexample the difference in definition of excessive alchool intake between the two groups).The textcontains some errors (ie Model 1 and Model 1)Table 3 is misleading. It should be better to add amore detailed title (i.e. Odds Ratios for Associations Between NAFLD and Risk of CKD)
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assessAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
'I declare that I have no competing interests'
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’ s report
Title: Association between NAFLD and risk of prevalent chronic kidney disease: Why there is a
difference between East and West?
Version: 0Date: 07 Feb 2020
Reviewer: Rosa Filiberti
Reviewer's report:
The authors used datasets from a Western and a Eastern population to clarify the association
between NAFLD and CKD. They concluded that NAFLD increases the risk of early stages CKDin both populations, while a significant association was found only for Chinese people whenconsidering all stages of CKD.I think that the use of different non standardized datasets, mainlythe difference in the considered period (1984 to 1994 for China and 2010 for USA) may haveinfluenced results. The authors should discuss better the limits of the study given also the fact thatthey compared two populations with large differences in lyfestile and dietary habits (see forexample the difference in definition of excessive alchool intake between the two groups).The textcontains some errors (ie Model 1 and Model 1)Table 3 is misleading. It should be better to add amore detailed title (i.e. Odds Ratios for Associations Between NAFLD and Risk of CKD)
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assessAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
'I declare that I have no competing interests'
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’ s report
Title: Association between NAFLD and risk of prevalent chronic kidney disease: Why there is a
difference between East and West?
Version: 0Date: 07 Feb 2020
Reviewer: Rosa Filiberti
Reviewer's report:
The authors used datasets from a Western and a Eastern population to clarify the association
between NAFLD and CKD. They concluded that NAFLD increases the risk of early stages CKDin both populations, while a significant association was found only for Chinese people whenconsidering all stages of CKD.I think that the use of different non standardized datasets, mainlythe difference in the considered period (1984 to 1994 for China and 2010 for USA) may haveinfluenced results. The authors should discuss better the limits of the study given also the fact thatthey compared two populations with large differences in lyfestile and dietary habits (see forexample the difference in definition of excessive alchool intake between the two groups).The textcontains some errors (ie Model 1 and Model 1)Table 3 is misleading. It should be better to add amore detailed title (i.e. Odds Ratios for Associations Between NAFLD and Risk of CKD)
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assessAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
NoAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statisticsQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
'I declare that I have no competing interests'
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant