Reviewer's report
Title:Carbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute
hepatic ischemia reperfusion injury in rats
Version: 2Date:9 March 2010
Reviewer: Bingwei Sun
Reviewer's report:
In this manuscript the authors describe the effect of a CO-releasing substance on
hepatic I/Ri in a rat model. The authors study the serum damage markers AST
and ALT, liver histology score, TUNEL-scoring of apoptotic cells, NF-#B-activity
in nuclear liver extracts, and hepatic neutrophil infiltration. They also monitor the
change of serum levels of pro-inflammatory cytokines TNF-# and IL-6. This study
seems to be well performed, the methods are adequate. The reason for the study
seems sound. The conclusions seem to be relevant and the literature covers the
subject. If it is felt to be within the remit of the BMC Gastroenterology, my
recommendation would be to accept without further revision.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Carbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute
hepatic ischemia reperfusion injury in rats
Version: 2Date:9 March 2010
Reviewer: Bingwei Sun
Reviewer's report:
In this manuscript the authors describe the effect of a CO-releasing substance on
hepatic I/Ri in a rat model. The authors study the serum damage markers AST
and ALT, liver histology score, TUNEL-scoring of apoptotic cells, NF-#B-activity
in nuclear liver extracts, and hepatic neutrophil infiltration. They also monitor the
change of serum levels of pro-inflammatory cytokines TNF-# and IL-6. This study
seems to be well performed, the methods are adequate. The reason for the study
seems sound. The conclusions seem to be relevant and the literature covers the
subject. If it is felt to be within the remit of the BMC Gastroenterology, my
recommendation would be to accept without further revision.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Carbon monoxide-Releasing Molecule-2 (CORM-2) attenuates acute
hepatic ischemia reperfusion injury in rats
Version: 2Date:9 March 2010
Reviewer: Bingwei Sun
Reviewer's report:
In this manuscript the authors describe the effect of a CO-releasing substance on
hepatic I/Ri in a rat model. The authors study the serum damage markers AST
and ALT, liver histology score, TUNEL-scoring of apoptotic cells, NF-#B-activity
in nuclear liver extracts, and hepatic neutrophil infiltration. They also monitor the
change of serum levels of pro-inflammatory cytokines TNF-# and IL-6. This study
seems to be well performed, the methods are adequate. The reason for the study
seems sound. The conclusions seem to be relevant and the literature covers the
subject. If it is felt to be within the remit of the BMC Gastroenterology, my
recommendation would be to accept without further revision.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant