Title: The impact of endoscopist performance and patient factors on distal adenoma detection
and colorectal cancer incidence.
Version: 2 Date: 20 Dec 2023
Reviewer's report:
In this clinicopathological study, authors assessed the impact of endoscopists’ performance
and patient factors on distal adenoma detection and colorectal cancer incidence. A large
number of patients were registered in this trial and more than 34,000 participants received
flexible sigmoidoscopy screening in the 13 centres. Median follow-up was 17 years. After a
detailed statistical analysis, they found that bowel preparation quality and longer insertion and
withdrawal time were key for improving distal adenoma detection. Additionally, it was indicated
that higher ADRs were associated with a lower risk of distal CRC. The main research findings
of this paper will be important for prediction and prevention of distal CRC. I have no practical
criticisms in terms of methods, results and interpretation.
Title: The impact of endoscopist performance and patient factors on distal adenoma detection
and colorectal cancer incidence.
Version: 2 Date: 20 Dec 2023
Reviewer's report:
In this clinicopathological study, authors assessed the impact of endoscopists’ performance
and patient factors on distal adenoma detection and colorectal cancer incidence. A large
number of patients were registered in this trial and more than 34,000 participants received
flexible sigmoidoscopy screening in the 13 centres. Median follow-up was 17 years. After a
detailed statistical analysis, they found that bowel preparation quality and longer insertion and
withdrawal time were key for improving distal adenoma detection. Additionally, it was indicated
that higher ADRs were associated with a lower risk of distal CRC. The main research findings
of this paper will be important for prediction and prevention of distal CRC. I have no practical
criticisms in terms of methods, results and interpretation.
Please review this paper.
user
Title: The impact of endoscopist performance and patient factors on distal adenoma detection
and colorectal cancer incidence.
Version: 2 Date: 20 Dec 2023
Reviewer's report:
In this clinicopathological study, authors assessed the impact of endoscopists’ performance
and patient factors on distal adenoma detection and colorectal cancer incidence. A large
number of patients were registered in this trial and more than 34,000 participants received
flexible sigmoidoscopy screening in the 13 centres. Median follow-up was 17 years. After a
detailed statistical analysis, they found that bowel preparation quality and longer insertion and
withdrawal time were key for improving distal adenoma detection. Additionally, it was indicated
that higher ADRs were associated with a lower risk of distal CRC. The main research findings
of this paper will be important for prediction and prevention of distal CRC. I have no practical
criticisms in terms of methods, results and interpretation.
assistant