Title: Novel Chemokine-Related LncRNA Signature Correlates with the Prognosis, Immune
Landscape, and Therapeutic Sensitivity of Esophageal Squamous Cell Cancer
Version: 1 Date: 28 Jan 2023
Reviewer's report:
Advanced ESCC is a heterogeneous disease with a dismal prognosis. Chemokines have a
substantial impact on tumor formation and immune infiltration. However, only a few researchers
have focused on the utilization of chemokine-related lncRNAs in the prognostic prediction of
ESCC. The authors built a robust prognostic model based on chemokine-related lncRNAs and
explored the TME in high- and low-risk subgroups. Overall, this theory is engaging, robust, and
replicable. However, the following problems still need to be solved.
1. The language of the manuscript needs to be fully embellished.
2. The P values were incorrectly written. Please use "capital" and "italic" consistently.
3. Cites in the article need to be improved to make the contents more complete.
3.1 In the Method part, the cites need to be improved: CIBERSORT R scripts were used to
quantify the relative proportion of infiltrating immune cells (DOI: 10.3389/fgene.2022.984273);
“Lasso regression analysis” was used to filter genes associated with prognosis (DOI: 10.3389/
fgene.2022.983672); “ssGSEA” method was adopted to differentiate patients sorted by risk
score (DOI: 10.3389/fimmu.2022.1018685).
3.2 In the discussion part, the contents, as well as related cites, also need to be improved: the
immune system plays important role in the development of cancers, as well as immunotherapy
(DOI: 10.3389/fimmu.2022.1022808). The authors analyzed the TME, therefore these contents
are essential to be discussed. Notably, tumor cells can produce many exosomes that may contain
chemokines and lncRNAs, which can transmit signals between tumor cells and promote their
growth and metastasis (DOI: 10.3389/fimmu.2022.1089410). Hence, the authors need to discuss
possible application prospects based on the in vivo distribution of chemokines.
Title: Novel Chemokine-Related LncRNA Signature Correlates with the Prognosis, Immune
Landscape, and Therapeutic Sensitivity of Esophageal Squamous Cell Cancer
Version: 1 Date: 28 Jan 2023
Reviewer's report:
Advanced ESCC is a heterogeneous disease with a dismal prognosis. Chemokines have a
substantial impact on tumor formation and immune infiltration. However, only a few researchers
have focused on the utilization of chemokine-related lncRNAs in the prognostic prediction of
ESCC. The authors built a robust prognostic model based on chemokine-related lncRNAs and
explored the TME in high- and low-risk subgroups. Overall, this theory is engaging, robust, and
replicable. However, the following problems still need to be solved.
1. The language of the manuscript needs to be fully embellished.
2. The P values were incorrectly written. Please use "capital" and "italic" consistently.
3. Cites in the article need to be improved to make the contents more complete.
3.1 In the Method part, the cites need to be improved: CIBERSORT R scripts were used to
quantify the relative proportion of infiltrating immune cells (DOI: 10.3389/fgene.2022.984273);
“Lasso regression analysis” was used to filter genes associated with prognosis (DOI: 10.3389/
fgene.2022.983672); “ssGSEA” method was adopted to differentiate patients sorted by risk
score (DOI: 10.3389/fimmu.2022.1018685).
3.2 In the discussion part, the contents, as well as related cites, also need to be improved: the
immune system plays important role in the development of cancers, as well as immunotherapy
(DOI: 10.3389/fimmu.2022.1022808). The authors analyzed the TME, therefore these contents
are essential to be discussed. Notably, tumor cells can produce many exosomes that may contain
chemokines and lncRNAs, which can transmit signals between tumor cells and promote their
growth and metastasis (DOI: 10.3389/fimmu.2022.1089410). Hence, the authors need to discuss
possible application prospects based on the in vivo distribution of chemokines.
Please review this paper.
user
Title: Novel Chemokine-Related LncRNA Signature Correlates with the Prognosis, Immune
Landscape, and Therapeutic Sensitivity of Esophageal Squamous Cell Cancer
Version: 1 Date: 28 Jan 2023
Reviewer's report:
Advanced ESCC is a heterogeneous disease with a dismal prognosis. Chemokines have a
substantial impact on tumor formation and immune infiltration. However, only a few researchers
have focused on the utilization of chemokine-related lncRNAs in the prognostic prediction of
ESCC. The authors built a robust prognostic model based on chemokine-related lncRNAs and
explored the TME in high- and low-risk subgroups. Overall, this theory is engaging, robust, and
replicable. However, the following problems still need to be solved.
1. The language of the manuscript needs to be fully embellished.
2. The P values were incorrectly written. Please use "capital" and "italic" consistently.
3. Cites in the article need to be improved to make the contents more complete.
3.1 In the Method part, the cites need to be improved: CIBERSORT R scripts were used to
quantify the relative proportion of infiltrating immune cells (DOI: 10.3389/fgene.2022.984273);
“Lasso regression analysis” was used to filter genes associated with prognosis (DOI: 10.3389/
fgene.2022.983672); “ssGSEA” method was adopted to differentiate patients sorted by risk
score (DOI: 10.3389/fimmu.2022.1018685).
3.2 In the discussion part, the contents, as well as related cites, also need to be improved: the
immune system plays important role in the development of cancers, as well as immunotherapy
(DOI: 10.3389/fimmu.2022.1022808). The authors analyzed the TME, therefore these contents
are essential to be discussed. Notably, tumor cells can produce many exosomes that may contain
chemokines and lncRNAs, which can transmit signals between tumor cells and promote their
growth and metastasis (DOI: 10.3389/fimmu.2022.1089410). Hence, the authors need to discuss
possible application prospects based on the in vivo distribution of chemokines.
assistant