Title: A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized
cirrhotic patients: A MIMIC database analysis
Version: 4 Date: 16 Jul 2024
Reviewer's report:
Objective:
The authors develop a predictive model of short-term AKI (<7 days) in cirrhotic patients
hospitalized in intensive care based on the MIMIC database.
General Impression:
The manuscript has precisely addressed the comments of the reviewers from the previous round,
and I congratulate the authors for considering them, significantly improving the quality of the
manuscript.
Major Points:
a. There is no mention in the manuscript of the causes of AKI retained, particularly hepatorenal
syndrome, a specific form of AKI in cirrhotic patients with a prognosis and therapy very different
from other causes of AKI. (DOI: https://doi.org/10.1016/j.jhep.2024.03.031). I would encourage
the authors to propose an annexed table listing the causes of AKI retained for diagnosis.
Minor Points:
I have notified some minor typographical and grammatical errors
• 46 : Acute kidney injury (AKI) is defined as a significant acute reduction in renal function and
is one of the most common complications in critically ill patients with cirrhosis, especially in
the intensive care unit (ICU)
• 57/59 : Therefore, early identification of ICU patients with cirrhosis who are at a high risk of
AKI is very important and may be helpful in providing timely medical interventions to improve
the prognosis of these patients.
• 103/04 : If there were multiple stays in the ICU during hospitalization, the data from the first
admission to the ICU was used
• 124/125 : liver transplantation before admission or during the hospital stay.
• 128 : m2) >90 days (19).
Title: A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized
cirrhotic patients: A MIMIC database analysis
Version: 4 Date: 16 Jul 2024
Reviewer's report:
Objective:
The authors develop a predictive model of short-term AKI (<7 days) in cirrhotic patients
hospitalized in intensive care based on the MIMIC database.
General Impression:
The manuscript has precisely addressed the comments of the reviewers from the previous round,
and I congratulate the authors for considering them, significantly improving the quality of the
manuscript.
Major Points:
a. There is no mention in the manuscript of the causes of AKI retained, particularly hepatorenal
syndrome, a specific form of AKI in cirrhotic patients with a prognosis and therapy very different
from other causes of AKI. (DOI: https://doi.org/10.1016/j.jhep.2024.03.031). I would encourage
the authors to propose an annexed table listing the causes of AKI retained for diagnosis.
Minor Points:
I have notified some minor typographical and grammatical errors
• 46 : Acute kidney injury (AKI) is defined as a significant acute reduction in renal function and
is one of the most common complications in critically ill patients with cirrhosis, especially in
the intensive care unit (ICU)
• 57/59 : Therefore, early identification of ICU patients with cirrhosis who are at a high risk of
AKI is very important and may be helpful in providing timely medical interventions to improve
the prognosis of these patients.
• 103/04 : If there were multiple stays in the ICU during hospitalization, the data from the first
admission to the ICU was used
• 124/125 : liver transplantation before admission or during the hospital stay.
• 128 : m2) >90 days (19).
Please review this paper.
user
Title: A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized
cirrhotic patients: A MIMIC database analysis
Version: 4 Date: 16 Jul 2024
Reviewer's report:
Objective:
The authors develop a predictive model of short-term AKI (<7 days) in cirrhotic patients
hospitalized in intensive care based on the MIMIC database.
General Impression:
The manuscript has precisely addressed the comments of the reviewers from the previous round,
and I congratulate the authors for considering them, significantly improving the quality of the
manuscript.
Major Points:
a. There is no mention in the manuscript of the causes of AKI retained, particularly hepatorenal
syndrome, a specific form of AKI in cirrhotic patients with a prognosis and therapy very different
from other causes of AKI. (DOI: https://doi.org/10.1016/j.jhep.2024.03.031). I would encourage
the authors to propose an annexed table listing the causes of AKI retained for diagnosis.
Minor Points:
I have notified some minor typographical and grammatical errors
• 46 : Acute kidney injury (AKI) is defined as a significant acute reduction in renal function and
is one of the most common complications in critically ill patients with cirrhosis, especially in
the intensive care unit (ICU)
• 57/59 : Therefore, early identification of ICU patients with cirrhosis who are at a high risk of
AKI is very important and may be helpful in providing timely medical interventions to improve
the prognosis of these patients.
• 103/04 : If there were multiple stays in the ICU during hospitalization, the data from the first
admission to the ICU was used
• 124/125 : liver transplantation before admission or during the hospital stay.
• 128 : m2) >90 days (19).
assistant