Title: Clinicopathological features of early-onset colorectal cancer in Japanese patients: A
single-center retrospective study
Version: 2 Date: 03 Oct 2024
Reviewer's report:
In this study, the clinicopathological findings of EoCRC among Japanese patients were
analyzed. It was suggested that EoCRC among Japanese patients tend to occur on the rectum
and is more frequently diagnosed with FIT screening compared to late-onset CRC. Furthermore,
patients with advanced stage were diagnosed by symptoms, indicating the usefulness of FIT
screening in diagnosing EoCRC at an early stage. Although interesting, this article is lack of
some explanations.
1. All patients in this study were Japanese. I would like to know the race of analyzed patients.
2. MSI status should be compared between the groups.
3. The prognosis was compared between the groups. However, the details of the treatment of
CRC in this study are unclear. Were all tumors completely resected? Endoscopic resection or
surgical resection? How were distant metastases treated? What were the details of postoperative
adjuvant chemotherapy? How were overall survival and disease-specific survival calculated?
With insufficient information on these issues, it is not possible to determine whether the study
is appropriate.
Title: Clinicopathological features of early-onset colorectal cancer in Japanese patients: A
single-center retrospective study
Version: 2 Date: 03 Oct 2024
Reviewer's report:
In this study, the clinicopathological findings of EoCRC among Japanese patients were
analyzed. It was suggested that EoCRC among Japanese patients tend to occur on the rectum
and is more frequently diagnosed with FIT screening compared to late-onset CRC. Furthermore,
patients with advanced stage were diagnosed by symptoms, indicating the usefulness of FIT
screening in diagnosing EoCRC at an early stage. Although interesting, this article is lack of
some explanations.
1. All patients in this study were Japanese. I would like to know the race of analyzed patients.
2. MSI status should be compared between the groups.
3. The prognosis was compared between the groups. However, the details of the treatment of
CRC in this study are unclear. Were all tumors completely resected? Endoscopic resection or
surgical resection? How were distant metastases treated? What were the details of postoperative
adjuvant chemotherapy? How were overall survival and disease-specific survival calculated?
With insufficient information on these issues, it is not possible to determine whether the study
is appropriate.
Please review this paper.
user
Title: Clinicopathological features of early-onset colorectal cancer in Japanese patients: A
single-center retrospective study
Version: 2 Date: 03 Oct 2024
Reviewer's report:
In this study, the clinicopathological findings of EoCRC among Japanese patients were
analyzed. It was suggested that EoCRC among Japanese patients tend to occur on the rectum
and is more frequently diagnosed with FIT screening compared to late-onset CRC. Furthermore,
patients with advanced stage were diagnosed by symptoms, indicating the usefulness of FIT
screening in diagnosing EoCRC at an early stage. Although interesting, this article is lack of
some explanations.
1. All patients in this study were Japanese. I would like to know the race of analyzed patients.
2. MSI status should be compared between the groups.
3. The prognosis was compared between the groups. However, the details of the treatment of
CRC in this study are unclear. Were all tumors completely resected? Endoscopic resection or
surgical resection? How were distant metastases treated? What were the details of postoperative
adjuvant chemotherapy? How were overall survival and disease-specific survival calculated?
With insufficient information on these issues, it is not possible to determine whether the study
is appropriate.
assistant