Title: Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition
criteria in nutritional diagnosis of hepatocellular carcinoma
Version: 3 Date: 12 Aug 2024
Reviewer:  Ana Brito-Costa
Reviewer's report:
This is a very interesting and clinically relevant paper that contributes to the understanding of
the best nutritional indicators in the prediction of clinical outcomes.
The manuscript has been carefully reviewed, but should still undergo a more detailed review
of the english writing (eg. influence of "nutriture" on liver disease: p.3, 1st paragraph; the
"counting" data were measured by a chi-square test: p. 5, 3rd paragraph).
Additionally, I would like some clarification about the exclusion criteria applied (some of them
do not make sense under the objective of assessing the prevalence of undernutrition using the
GLIM criteria).
The methodology states that the GLIM criteria were only applied to individuals classified with
nutritional risk by the NRS-2002; however, data subsequently indicates that all individuals were
classified using the GLIM criteria. Can you clarify?
Why  youdid not assess the severity of malnutrition?
Finnally, regarding the low intake criteria, did the authors compare macronutrient intake with
the recommended intake or just used the energy intake? It would be interesting to see if there is
any relation between the deficient intake of any specific macronutrient.
Title: Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition
criteria in nutritional diagnosis of hepatocellular carcinoma
Version: 3 Date: 12 Aug 2024
Reviewer:  Ana Brito-Costa
Reviewer's report:
This is a very interesting and clinically relevant paper that contributes to the understanding of
the best nutritional indicators in the prediction of clinical outcomes.
The manuscript has been carefully reviewed, but should still undergo a more detailed review
of the english writing (eg. influence of "nutriture" on liver disease: p.3, 1st paragraph; the
"counting" data were measured by a chi-square test: p. 5, 3rd paragraph).
Additionally, I would like some clarification about the exclusion criteria applied (some of them
do not make sense under the objective of assessing the prevalence of undernutrition using the
GLIM criteria).
The methodology states that the GLIM criteria were only applied to individuals classified with
nutritional risk by the NRS-2002; however, data subsequently indicates that all individuals were
classified using the GLIM criteria. Can you clarify?
Why  youdid not assess the severity of malnutrition?
Finnally, regarding the low intake criteria, did the authors compare macronutrient intake with
the recommended intake or just used the energy intake? It would be interesting to see if there is
any relation between the deficient intake of any specific macronutrient.
Please review this paper.
user
Title: Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition
criteria in nutritional diagnosis of hepatocellular carcinoma
Version: 3 Date: 12 Aug 2024
Reviewer:  Ana Brito-Costa
Reviewer's report:
This is a very interesting and clinically relevant paper that contributes to the understanding of
the best nutritional indicators in the prediction of clinical outcomes.
The manuscript has been carefully reviewed, but should still undergo a more detailed review
of the english writing (eg. influence of "nutriture" on liver disease: p.3, 1st paragraph; the
"counting" data were measured by a chi-square test: p. 5, 3rd paragraph).
Additionally, I would like some clarification about the exclusion criteria applied (some of them
do not make sense under the objective of assessing the prevalence of undernutrition using the
GLIM criteria).
The methodology states that the GLIM criteria were only applied to individuals classified with
nutritional risk by the NRS-2002; however, data subsequently indicates that all individuals were
classified using the GLIM criteria. Can you clarify?
Why  youdid not assess the severity of malnutrition?
Finnally, regarding the low intake criteria, did the authors compare macronutrient intake with
the recommended intake or just used the energy intake? It would be interesting to see if there is
any relation between the deficient intake of any specific macronutrient.
assistant