Title: Alterations of Liver Enzymes and Lipid Profile in Response to Exhaustive Eccentric
Exercise: Vitamin D supplementation trial in Overweight Females with Non-Alcoholic Fatty
Liver Disease
Version: 3 Date: 11 May 2022
Reviewer's report:
2. In page 3, Please check the sentence “The prevalence of Vit D deficiency in the Vatandoust
et al.  (2018) meta-analysis study was 56%, of which 64% were female and 59.8%  of whom
were over 50 years [17]”.
3. What is purpose of separate research protocol file? Is it going to be a supplementary file? But
majority of information in research protocol file is in main manuscript.
4. In Table 1. “Mean ± SD of anthropometric indices before the intervention among the groups”,
for control group, why the authors included the data from pre 2 and post 2 exercise.
5. In table to please check the statistics for BW, BMI, PFB and WHR.
6. Fig 3, the data in x-axis should be in order, like Pre1, post1, pre2, post 2.
7. Even though, the Vit D or exercise is not improving serum lipid profile, the majority of
discussion is about Vit D and lipid metabolism.
8. Finally, is there any reason to suggest the EEE type exercise to NAFLD patient. Are there
any detail study reports available regarding this EEE in NAFLD patients? If yes, please include
reference.
Title: Alterations of Liver Enzymes and Lipid Profile in Response to Exhaustive Eccentric
Exercise: Vitamin D supplementation trial in Overweight Females with Non-Alcoholic Fatty
Liver Disease
Version: 3 Date: 11 May 2022
Reviewer's report:
2. In page 3, Please check the sentence “The prevalence of Vit D deficiency in the Vatandoust
et al.  (2018) meta-analysis study was 56%, of which 64% were female and 59.8%  of whom
were over 50 years [17]”.
3. What is purpose of separate research protocol file? Is it going to be a supplementary file? But
majority of information in research protocol file is in main manuscript.
4. In Table 1. “Mean ± SD of anthropometric indices before the intervention among the groups”,
for control group, why the authors included the data from pre 2 and post 2 exercise.
5. In table to please check the statistics for BW, BMI, PFB and WHR.
6. Fig 3, the data in x-axis should be in order, like Pre1, post1, pre2, post 2.
7. Even though, the Vit D or exercise is not improving serum lipid profile, the majority of
discussion is about Vit D and lipid metabolism.
8. Finally, is there any reason to suggest the EEE type exercise to NAFLD patient. Are there
any detail study reports available regarding this EEE in NAFLD patients? If yes, please include
reference.
Please review this paper.
user
Title: Alterations of Liver Enzymes and Lipid Profile in Response to Exhaustive Eccentric
Exercise: Vitamin D supplementation trial in Overweight Females with Non-Alcoholic Fatty
Liver Disease
Version: 3 Date: 11 May 2022
Reviewer's report:
2. In page 3, Please check the sentence “The prevalence of Vit D deficiency in the Vatandoust
et al.  (2018) meta-analysis study was 56%, of which 64% were female and 59.8%  of whom
were over 50 years [17]”.
3. What is purpose of separate research protocol file? Is it going to be a supplementary file? But
majority of information in research protocol file is in main manuscript.
4. In Table 1. “Mean ± SD of anthropometric indices before the intervention among the groups”,
for control group, why the authors included the data from pre 2 and post 2 exercise.
5. In table to please check the statistics for BW, BMI, PFB and WHR.
6. Fig 3, the data in x-axis should be in order, like Pre1, post1, pre2, post 2.
7. Even though, the Vit D or exercise is not improving serum lipid profile, the majority of
discussion is about Vit D and lipid metabolism.
8. Finally, is there any reason to suggest the EEE type exercise to NAFLD patient. Are there
any detail study reports available regarding this EEE in NAFLD patients? If yes, please include
reference.
assistant