Title: Long-term outcomes of refractory esophageal strictures after endoscopic submucosal
dissection of superficial esophageal neoplasms
Version: 2 Date: 22 Nov 2021
Reviewer's report:
To the author
This manuscript was evaluated the risk factor of the stricture after extensive ESD of esophageal
neoplasia. Stricture after extensive ESD is important factor for esophageal ESD. However, there
are some concerns before publication from BMC gastroenterology.
1. Author described “prospectively collected the date of 853 lesions in 686 patients” in the
method section. However, this study is retrospective study and author should explain the
inclusion criteria and exclusion criteria more precisely in the method section.
2. Author should submit the flowchart of this study.
3. Author include the patients of various treatment for the esophageal stricture such as dilatation,
bougie and stent. However, esophageal stenting is completely different treatment. Author should
exclude the patients with the stenting treatment. Or author should state the treatment method of
the stenting in detail.
4. Author should explain RESs in the abstract.
5. Oral intake and local injection is controversial so author should discuss this point.
6. Yamaguchi et al reported the utility of oral prednisolone for esophageal stricture after
extensive ESD in gastrointestinal endoscopy (Yamaguchi N et al. Gastrointest Endosc 2011. 73:
1115-1121.) Author should cite this report.
Title: Long-term outcomes of refractory esophageal strictures after endoscopic submucosal
dissection of superficial esophageal neoplasms
Version: 2 Date: 22 Nov 2021
Reviewer's report:
To the author
This manuscript was evaluated the risk factor of the stricture after extensive ESD of esophageal
neoplasia. Stricture after extensive ESD is important factor for esophageal ESD. However, there
are some concerns before publication from BMC gastroenterology.
1. Author described “prospectively collected the date of 853 lesions in 686 patients” in the
method section. However, this study is retrospective study and author should explain the
inclusion criteria and exclusion criteria more precisely in the method section.
2. Author should submit the flowchart of this study.
3. Author include the patients of various treatment for the esophageal stricture such as dilatation,
bougie and stent. However, esophageal stenting is completely different treatment. Author should
exclude the patients with the stenting treatment. Or author should state the treatment method of
the stenting in detail.
4. Author should explain RESs in the abstract.
5. Oral intake and local injection is controversial so author should discuss this point.
6. Yamaguchi et al reported the utility of oral prednisolone for esophageal stricture after
extensive ESD in gastrointestinal endoscopy (Yamaguchi N et al. Gastrointest Endosc 2011. 73:
1115-1121.) Author should cite this report.
Please review this paper.
user
Title: Long-term outcomes of refractory esophageal strictures after endoscopic submucosal
dissection of superficial esophageal neoplasms
Version: 2 Date: 22 Nov 2021
Reviewer's report:
To the author
This manuscript was evaluated the risk factor of the stricture after extensive ESD of esophageal
neoplasia. Stricture after extensive ESD is important factor for esophageal ESD. However, there
are some concerns before publication from BMC gastroenterology.
1. Author described “prospectively collected the date of 853 lesions in 686 patients” in the
method section. However, this study is retrospective study and author should explain the
inclusion criteria and exclusion criteria more precisely in the method section.
2. Author should submit the flowchart of this study.
3. Author include the patients of various treatment for the esophageal stricture such as dilatation,
bougie and stent. However, esophageal stenting is completely different treatment. Author should
exclude the patients with the stenting treatment. Or author should state the treatment method of
the stenting in detail.
4. Author should explain RESs in the abstract.
5. Oral intake and local injection is controversial so author should discuss this point.
6. Yamaguchi et al reported the utility of oral prednisolone for esophageal stricture after
extensive ESD in gastrointestinal endoscopy (Yamaguchi N et al. Gastrointest Endosc 2011. 73:
1115-1121.) Author should cite this report.
assistant