Reviewer’ s report
Title: A rare hepatic mass in an Italian resident
Version: 0Date: 06 May 2020
Reviewer's report:1. I have attached the file which shows the edited Abstract I have done for you. I have included
track changes there so you could followup with similar changes in your manuscript. It is essential
that grammar and format is ideal prior to publication.
2. Your abscess is single with some outpouching and this should not be classified as 'multiple'
abscesses. It is wrong. The image doesn't show multiple. It is a single abscess with loculation. Sochange it please. Make this as single abscess. Also amend the following statement - "The threemajor nodules were 7 cm, 9 cm and 4 cm in diameter respectively (Fig 1, Panel A). ". Your casehas SINGLE ABSCESS. Report 1 size. You could report in 3 dimensions.
3. Mention full form of HIV . Authors need to consider full forms for all short forms4. Agree that large abscess should be drained. Antibiotics are NOT indicated on its own.
Percutaneous drainage + Antibiotics should be used togather. It appears you decided to managewith antibiotics along until patient deteriorated and than you decided to drain the abscess. This isnot ideal management as such. You are fortunate to save life by draining. It is advised thatdrainage should be done early for any patients with abscess > 4 cm size and this is shown indiverticular disease abscess as well as pyogenic liver abscess (PMID - 26133908). It is alsoimportant to note that you have rightly pointed out that rupture is a potentially dangerous
complication and this may warrant surgery. It is also important to note that rupture is less common
and majority of patients with giant abscess can be managed with drainage alone (PMID -26033361).
5. You started patient on meropenem and vancomycin. Is this based on local antibiogram? Is there
antibiotic stewardship program in your hospital? Please consider adding some discussion alongthese lines (PMID - 28785302)
ThanksAre the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
No
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
nilReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.If
you are not happy for us to publish this report, please contact the editorial office before completing
the review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
Reviewer’ s report
Title: A rare hepatic mass in an Italian resident
Version: 0Date: 06 May 2020
Reviewer's report:1. I have attached the file which shows the edited Abstract I have done for you. I have included
track changes there so you could followup with similar changes in your manuscript. It is essential
that grammar and format is ideal prior to publication.
2. Your abscess is single with some outpouching and this should not be classified as 'multiple'
abscesses. It is wrong. The image doesn't show multiple. It is a single abscess with loculation. Sochange it please. Make this as single abscess. Also amend the following statement - "The threemajor nodules were 7 cm, 9 cm and 4 cm in diameter respectively (Fig 1, Panel A). ". Your casehas SINGLE ABSCESS. Report 1 size. You could report in 3 dimensions.
3. Mention full form of HIV . Authors need to consider full forms for all short forms4. Agree that large abscess should be drained. Antibiotics are NOT indicated on its own.
Percutaneous drainage + Antibiotics should be used togather. It appears you decided to managewith antibiotics along until patient deteriorated and than you decided to drain the abscess. This isnot ideal management as such. You are fortunate to save life by draining. It is advised thatdrainage should be done early for any patients with abscess > 4 cm size and this is shown indiverticular disease abscess as well as pyogenic liver abscess (PMID - 26133908). It is alsoimportant to note that you have rightly pointed out that rupture is a potentially dangerous
complication and this may warrant surgery. It is also important to note that rupture is less common
and majority of patients with giant abscess can be managed with drainage alone (PMID -26033361).
5. You started patient on meropenem and vancomycin. Is this based on local antibiogram? Is there
antibiotic stewardship program in your hospital? Please consider adding some discussion alongthese lines (PMID - 28785302)
ThanksAre the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
No
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
nilReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.If
you are not happy for us to publish this report, please contact the editorial office before completing
the review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
Please review this paper.
user
Reviewer’ s report
Title: A rare hepatic mass in an Italian resident
Version: 0Date: 06 May 2020
Reviewer's report:1. I have attached the file which shows the edited Abstract I have done for you. I have included
track changes there so you could followup with similar changes in your manuscript. It is essential
that grammar and format is ideal prior to publication.
2. Your abscess is single with some outpouching and this should not be classified as 'multiple'
abscesses. It is wrong. The image doesn't show multiple. It is a single abscess with loculation. Sochange it please. Make this as single abscess. Also amend the following statement - "The threemajor nodules were 7 cm, 9 cm and 4 cm in diameter respectively (Fig 1, Panel A). ". Your casehas SINGLE ABSCESS. Report 1 size. You could report in 3 dimensions.
3. Mention full form of HIV . Authors need to consider full forms for all short forms4. Agree that large abscess should be drained. Antibiotics are NOT indicated on its own.
Percutaneous drainage + Antibiotics should be used togather. It appears you decided to managewith antibiotics along until patient deteriorated and than you decided to drain the abscess. This isnot ideal management as such. You are fortunate to save life by draining. It is advised thatdrainage should be done early for any patients with abscess > 4 cm size and this is shown indiverticular disease abscess as well as pyogenic liver abscess (PMID - 26133908). It is alsoimportant to note that you have rightly pointed out that rupture is a potentially dangerous
complication and this may warrant surgery. It is also important to note that rupture is less common
and majority of patients with giant abscess can be managed with drainage alone (PMID -26033361).
5. You started patient on meropenem and vancomycin. Is this based on local antibiogram? Is there
antibiotic stewardship program in your hospital? Please consider adding some discussion alongthese lines (PMID - 28785302)
ThanksAre the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
No
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
nilReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.If
you are not happy for us to publish this report, please contact the editorial office before completing
the review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
assistant