Title: Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and
Gallstone Prevalence in the American Adult Population: A Cross-Sectional Study Analysis
Version: 1 Date: 30 Dec 2024
Reviewer's report:
1.Is the choice of covariates based on the literature of existing relevant studies or on clinical
experience?
2.Given the strong association between obesity and gallstones, it is recommended that subgroup
analyses of BMI be supplemented to see if there is a robust effect in both obese and non-obese
populations.
3.Given the nonlinear relationship of the smoothed curve-fit plots, it is recommended that the
threshold effects analysis be supplemented to look for potential inflection points.
4.The association between PHR and risk of gallstone development found in this study through
subgroup analyses was strongest among participants aged 20-39 years, women, and individuals
from other racial/ethnic groups. However, the reasons for this phenomenon were not explained
in the discussion section, and additional refinements are recommended.
Title: Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and
Gallstone Prevalence in the American Adult Population: A Cross-Sectional Study Analysis
Version: 1 Date: 30 Dec 2024
Reviewer's report:
1.Is the choice of covariates based on the literature of existing relevant studies or on clinical
experience?
2.Given the strong association between obesity and gallstones, it is recommended that subgroup
analyses of BMI be supplemented to see if there is a robust effect in both obese and non-obese
populations.
3.Given the nonlinear relationship of the smoothed curve-fit plots, it is recommended that the
threshold effects analysis be supplemented to look for potential inflection points.
4.The association between PHR and risk of gallstone development found in this study through
subgroup analyses was strongest among participants aged 20-39 years, women, and individuals
from other racial/ethnic groups. However, the reasons for this phenomenon were not explained
in the discussion section, and additional refinements are recommended.
Please review this paper.
user
Title: Association Between Platelet-to-High-Density Lipoprotein Cholesterol Ratio and
Gallstone Prevalence in the American Adult Population: A Cross-Sectional Study Analysis
Version: 1 Date: 30 Dec 2024
Reviewer's report:
1.Is the choice of covariates based on the literature of existing relevant studies or on clinical
experience?
2.Given the strong association between obesity and gallstones, it is recommended that subgroup
analyses of BMI be supplemented to see if there is a robust effect in both obese and non-obese
populations.
3.Given the nonlinear relationship of the smoothed curve-fit plots, it is recommended that the
threshold effects analysis be supplemented to look for potential inflection points.
4.The association between PHR and risk of gallstone development found in this study through
subgroup analyses was strongest among participants aged 20-39 years, women, and individuals
from other racial/ethnic groups. However, the reasons for this phenomenon were not explained
in the discussion section, and additional refinements are recommended.
assistant