Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 5 Date: 15 Feb 2021
Reviewer's report:
In the revised version of the manuscript, the authors have responded some comments and added
some new data. However, the authors did not address the comments appropriate.
1. To reply reviewer 1 comment 1, the authors stated that the results in peripheral blood samples
may be more representative. The authors should explain why peripheral blood samples may be
more representative.
2.  Why did the authors present CNV data was by pair? The authors mentioned that NAFLD
was divided into three grades. Does the CNV significant different between different grades?
3. To reply reviewer 1 comment 7. The authors did not answer the principle of grade division.
4. The Figures are rough. Missing Y-axis labels in Figure1and 3 and missing all the labels in
heatmap.
5. The paper should be extensively revised to avoid grammar errors, typos and description
inaccuracy.
Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 5 Date: 15 Feb 2021
Reviewer's report:
In the revised version of the manuscript, the authors have responded some comments and added
some new data. However, the authors did not address the comments appropriate.
1. To reply reviewer 1 comment 1, the authors stated that the results in peripheral blood samples
may be more representative. The authors should explain why peripheral blood samples may be
more representative.
2.  Why did the authors present CNV data was by pair? The authors mentioned that NAFLD
was divided into three grades. Does the CNV significant different between different grades?
3. To reply reviewer 1 comment 7. The authors did not answer the principle of grade division.
4. The Figures are rough. Missing Y-axis labels in Figure1and 3 and missing all the labels in
heatmap.
5. The paper should be extensively revised to avoid grammar errors, typos and description
inaccuracy.
Please review this paper.
user
Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 5 Date: 15 Feb 2021
Reviewer's report:
In the revised version of the manuscript, the authors have responded some comments and added
some new data. However, the authors did not address the comments appropriate.
1. To reply reviewer 1 comment 1, the authors stated that the results in peripheral blood samples
may be more representative. The authors should explain why peripheral blood samples may be
more representative.
2.  Why did the authors present CNV data was by pair? The authors mentioned that NAFLD
was divided into three grades. Does the CNV significant different between different grades?
3. To reply reviewer 1 comment 7. The authors did not answer the principle of grade division.
4. The Figures are rough. Missing Y-axis labels in Figure1and 3 and missing all the labels in
heatmap.
5. The paper should be extensively revised to avoid grammar errors, typos and description
inaccuracy.
assistant