Title: Prolonged time interval from neoadjuvant immunotherapy combined with chemotherapy
to surgery is related to unimproved pathological response and poor survival prognosis for
esophageal squamous cell carcinoma
Version: 1 Date: 10 Dec 2024
Reviewer's report:
I read your research paper focused on time interval form neoadjuvant chemotherapy and found
your conclusion that delayed surgery does not improve survival.
However, I have two suggestions below to strengthen your analysis.
1. I recommend to add sensitivity analyses using 4-week, 5-week, and 7-week cutoff.
2.” A 6-week cutoff was chosen based on clinical trials that typically used this time frame.”
# Addition of the data above, it would be helpful to support your conclusion. “ We observed
similar trends (4-, 5-, 6- and 7- week cutoff),,,,“
I think it would be an even better paper if you mentioned the effectiveness of early surgery.
Title: Prolonged time interval from neoadjuvant immunotherapy combined with chemotherapy
to surgery is related to unimproved pathological response and poor survival prognosis for
esophageal squamous cell carcinoma
Version: 1 Date: 10 Dec 2024
Reviewer's report:
I read your research paper focused on time interval form neoadjuvant chemotherapy and found
your conclusion that delayed surgery does not improve survival.
However, I have two suggestions below to strengthen your analysis.
1. I recommend to add sensitivity analyses using 4-week, 5-week, and 7-week cutoff.
2.” A 6-week cutoff was chosen based on clinical trials that typically used this time frame.”
# Addition of the data above, it would be helpful to support your conclusion. “ We observed
similar trends (4-, 5-, 6- and 7- week cutoff),,,,“
I think it would be an even better paper if you mentioned the effectiveness of early surgery.
Please review this paper.
user
Title: Prolonged time interval from neoadjuvant immunotherapy combined with chemotherapy
to surgery is related to unimproved pathological response and poor survival prognosis for
esophageal squamous cell carcinoma
Version: 1 Date: 10 Dec 2024
Reviewer's report:
I read your research paper focused on time interval form neoadjuvant chemotherapy and found
your conclusion that delayed surgery does not improve survival.
However, I have two suggestions below to strengthen your analysis.
1. I recommend to add sensitivity analyses using 4-week, 5-week, and 7-week cutoff.
2.” A 6-week cutoff was chosen based on clinical trials that typically used this time frame.”
# Addition of the data above, it would be helpful to support your conclusion. “ We observed
similar trends (4-, 5-, 6- and 7- week cutoff),,,,“
I think it would be an even better paper if you mentioned the effectiveness of early surgery.
assistant