Title: Is Serum Albumin a Pivotal Biomarker in Anticipating Acute Pancreatitis Outcomes?
Version: 4 Date: 22 May 2024
Reviewer's report:
Dear Authors,
I read the manuscript entitled ''Is Serum Albumin a Pivotal Biomarker in Anticipating Acute
Pancreatitis Outcomes?''. You present here the impact of hypoalbuminemia in the first day of
hospitalization on prognosis and outcomes of acute pancreatitis. It is well-known that albumin
is a negative acute phase reactant and, albumin level has been affected by many factors in
acute pancreatitis. Several interesting results were presented in this study. I think you should
present your real-life data using severity indices like BISAP. There are some concerns about the
manuscript. I have the following comments and suggestions for the authors:
Major Comments:
1- You may present your findings by using BISAP as a severity index and compare albumin and
other laboratory markers to predict severe cases.
2- According to your study results, 75% of the patients have hypoalbuminemia, when the
albumin cut-off value was accepted as 30 g/L. However, the proportion of patients with severe
AP requiring close monitoring is in the range of 15%-20%. This cut-off value does not seem
to be sufficient to identify severe AP cases. The normal range of serum albumin range from
35 g/L to 50 g/L and, hypoalbuminemia has been widely accepted as <35 g/L in the literature.
Moreover, a cut-off value of marked hypoalbuminemia is accepted as 25 g/L in several studies.
Why did you choose an albumin cut-off of 30 g/L? marked hypoalbuminemia.
Minor Comments:
1- Page 4, line 17: “sexe” shold be corrected.
2- Page 5, line 29: You present normal albumin values as g/dL, please correct.
3- Page 7, line 8: “clinical-biological severity scores”. What did you mean with “clinical-
biological”
Title: Is Serum Albumin a Pivotal Biomarker in Anticipating Acute Pancreatitis Outcomes?
Version: 4 Date: 22 May 2024
Reviewer's report:
Dear Authors,
I read the manuscript entitled ''Is Serum Albumin a Pivotal Biomarker in Anticipating Acute
Pancreatitis Outcomes?''. You present here the impact of hypoalbuminemia in the first day of
hospitalization on prognosis and outcomes of acute pancreatitis. It is well-known that albumin
is a negative acute phase reactant and, albumin level has been affected by many factors in
acute pancreatitis. Several interesting results were presented in this study. I think you should
present your real-life data using severity indices like BISAP. There are some concerns about the
manuscript. I have the following comments and suggestions for the authors:
Major Comments:
1- You may present your findings by using BISAP as a severity index and compare albumin and
other laboratory markers to predict severe cases.
2- According to your study results, 75% of the patients have hypoalbuminemia, when the
albumin cut-off value was accepted as 30 g/L. However, the proportion of patients with severe
AP requiring close monitoring is in the range of 15%-20%. This cut-off value does not seem
to be sufficient to identify severe AP cases. The normal range of serum albumin range from
35 g/L to 50 g/L and, hypoalbuminemia has been widely accepted as <35 g/L in the literature.
Moreover, a cut-off value of marked hypoalbuminemia is accepted as 25 g/L in several studies.
Why did you choose an albumin cut-off of 30 g/L? marked hypoalbuminemia.
Minor Comments:
1- Page 4, line 17: “sexe” shold be corrected.
2- Page 5, line 29: You present normal albumin values as g/dL, please correct.
3- Page 7, line 8: “clinical-biological severity scores”. What did you mean with “clinical-
biological”
Please review this paper.
user
Title: Is Serum Albumin a Pivotal Biomarker in Anticipating Acute Pancreatitis Outcomes?
Version: 4 Date: 22 May 2024
Reviewer's report:
Dear Authors,
I read the manuscript entitled ''Is Serum Albumin a Pivotal Biomarker in Anticipating Acute
Pancreatitis Outcomes?''. You present here the impact of hypoalbuminemia in the first day of
hospitalization on prognosis and outcomes of acute pancreatitis. It is well-known that albumin
is a negative acute phase reactant and, albumin level has been affected by many factors in
acute pancreatitis. Several interesting results were presented in this study. I think you should
present your real-life data using severity indices like BISAP. There are some concerns about the
manuscript. I have the following comments and suggestions for the authors:
Major Comments:
1- You may present your findings by using BISAP as a severity index and compare albumin and
other laboratory markers to predict severe cases.
2- According to your study results, 75% of the patients have hypoalbuminemia, when the
albumin cut-off value was accepted as 30 g/L. However, the proportion of patients with severe
AP requiring close monitoring is in the range of 15%-20%. This cut-off value does not seem
to be sufficient to identify severe AP cases. The normal range of serum albumin range from
35 g/L to 50 g/L and, hypoalbuminemia has been widely accepted as <35 g/L in the literature.
Moreover, a cut-off value of marked hypoalbuminemia is accepted as 25 g/L in several studies.
Why did you choose an albumin cut-off of 30 g/L? marked hypoalbuminemia.
Minor Comments:
1- Page 4, line 17: “sexe” shold be corrected.
2- Page 5, line 29: You present normal albumin values as g/dL, please correct.
3- Page 7, line 8: “clinical-biological severity scores”. What did you mean with “clinical-
biological”
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