Title: Gastric cancer risk after Helicobacter pylori eradication in gastritis and peptic ulcer: a
retrospective cohort study in Japan
Version: 1 Date: 20 Feb 2025
Reviewer's report:
General:
In this article, authors aimed to investigate differences in gastric cancer risk among patients
with gastritis, gastric ulcer, duodenal ulcer, and gastric ulcer and duodenal ulcer after H. pylori
eradication. Authors showed that patients with H. pylori–associated gastritis and gastric ulcer
had a higher risk of gastric cancer than patients with duodenal ulcer.
Comments:
1. Patients with H. pylori–associated gastritis and gastric ulcer had a higher risk of gastric cancer
than patients with duodenal ulcer. Authors should show risk of gastric cancer for patients with
diseases by using risk of patients with gastritis alone as reference. If authors use risk of gastric
cancer for patients with diseases by using risk of patients with duodenal ulcer as reference, it
may confuse to understand. Please cut above parts of Table 2.
2. Authors concluded that endoscopic examination is required after successful eradication of H.
pylori in patients with severe baseline gastric atrophy. However, in abstract, there was no data
supported this evidence.
3. Evaluation of the difference in gastric cancer risk among patients with HPAG, GU, DU, and
gastric ulcer and duodenal ulcer after H. pylori eradication is limited. Authors should be carefully
researched. In addition, authors should show previous brief summary in Introduction.
4. Authors included patients received the first-line eradication therapy. Why did not authors
include patients received the second-line eradication therapy?
5. Authors excluded patients diagnosed with cancer within 1 year before or after index month.
Because patients with past history of gastric cancer have higher risk of gastric cancer, authors
should exclude patients with past history of gastric cancer, irrespective periods.
6. Please add p values in Table 1
7. Most of patients had no endoscopy (77~90%) (table 1). How were patients diagnosed peptic
ulcers?
8. How did authors check eradication success? Eradication rates may differ between patients
with gastric ulcer and duodenal ulcer. If so, this study may have bias.
9. This is Japanese cohort data. How about Western countries?
Title: Gastric cancer risk after Helicobacter pylori eradication in gastritis and peptic ulcer: a
retrospective cohort study in Japan
Version: 1 Date: 20 Feb 2025
Reviewer's report:
General:
In this article, authors aimed to investigate differences in gastric cancer risk among patients
with gastritis, gastric ulcer, duodenal ulcer, and gastric ulcer and duodenal ulcer after H. pylori
eradication. Authors showed that patients with H. pylori–associated gastritis and gastric ulcer
had a higher risk of gastric cancer than patients with duodenal ulcer.
Comments:
1. Patients with H. pylori–associated gastritis and gastric ulcer had a higher risk of gastric cancer
than patients with duodenal ulcer. Authors should show risk of gastric cancer for patients with
diseases by using risk of patients with gastritis alone as reference. If authors use risk of gastric
cancer for patients with diseases by using risk of patients with duodenal ulcer as reference, it
may confuse to understand. Please cut above parts of Table 2.
2. Authors concluded that endoscopic examination is required after successful eradication of H.
pylori in patients with severe baseline gastric atrophy. However, in abstract, there was no data
supported this evidence.
3. Evaluation of the difference in gastric cancer risk among patients with HPAG, GU, DU, and
gastric ulcer and duodenal ulcer after H. pylori eradication is limited. Authors should be carefully
researched. In addition, authors should show previous brief summary in Introduction.
4. Authors included patients received the first-line eradication therapy. Why did not authors
include patients received the second-line eradication therapy?
5. Authors excluded patients diagnosed with cancer within 1 year before or after index month.
Because patients with past history of gastric cancer have higher risk of gastric cancer, authors
should exclude patients with past history of gastric cancer, irrespective periods.
6. Please add p values in Table 1
7. Most of patients had no endoscopy (77~90%) (table 1). How were patients diagnosed peptic
ulcers?
8. How did authors check eradication success? Eradication rates may differ between patients
with gastric ulcer and duodenal ulcer. If so, this study may have bias.
9. This is Japanese cohort data. How about Western countries?
Please review this paper.
user
Title: Gastric cancer risk after Helicobacter pylori eradication in gastritis and peptic ulcer: a
retrospective cohort study in Japan
Version: 1 Date: 20 Feb 2025
Reviewer's report:
General:
In this article, authors aimed to investigate differences in gastric cancer risk among patients
with gastritis, gastric ulcer, duodenal ulcer, and gastric ulcer and duodenal ulcer after H. pylori
eradication. Authors showed that patients with H. pylori–associated gastritis and gastric ulcer
had a higher risk of gastric cancer than patients with duodenal ulcer.
Comments:
1. Patients with H. pylori–associated gastritis and gastric ulcer had a higher risk of gastric cancer
than patients with duodenal ulcer. Authors should show risk of gastric cancer for patients with
diseases by using risk of patients with gastritis alone as reference. If authors use risk of gastric
cancer for patients with diseases by using risk of patients with duodenal ulcer as reference, it
may confuse to understand. Please cut above parts of Table 2.
2. Authors concluded that endoscopic examination is required after successful eradication of H.
pylori in patients with severe baseline gastric atrophy. However, in abstract, there was no data
supported this evidence.
3. Evaluation of the difference in gastric cancer risk among patients with HPAG, GU, DU, and
gastric ulcer and duodenal ulcer after H. pylori eradication is limited. Authors should be carefully
researched. In addition, authors should show previous brief summary in Introduction.
4. Authors included patients received the first-line eradication therapy. Why did not authors
include patients received the second-line eradication therapy?
5. Authors excluded patients diagnosed with cancer within 1 year before or after index month.
Because patients with past history of gastric cancer have higher risk of gastric cancer, authors
should exclude patients with past history of gastric cancer, irrespective periods.
6. Please add p values in Table 1
7. Most of patients had no endoscopy (77~90%) (table 1). How were patients diagnosed peptic
ulcers?
8. How did authors check eradication success? Eradication rates may differ between patients
with gastric ulcer and duodenal ulcer. If so, this study may have bias.
9. This is Japanese cohort data. How about Western countries?
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