Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 5 Date: 29 Aug 2024
Reviewer's report:
The manuscript by Yan and coworkers titled ‘KIF3C inhibits the progression and proliferation of
colorectal cancer through PI3K/AKT pathway’ describes the role of KIF3C in colorectal cancer
tumorigenesis and its molecular mechanism. This is an interesting study.
I ask authors to address the following minor comments.
1.      To convincingly establish that KIF3C promotes proliferation and migration through
PI3K/AKT signaling, please conduct a rescue experiment wherein proliferation and migration is
measured after ectopically expressing KIF3C following treatment with PI3K or AKT inhibitor.
2.      Please show higher magnification images of IHC shown in figure 1a (in inset).
3.      Please show median survival and hazard ratio for survival curve shown in figure 1F.
Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 5 Date: 29 Aug 2024
Reviewer's report:
The manuscript by Yan and coworkers titled ‘KIF3C inhibits the progression and proliferation of
colorectal cancer through PI3K/AKT pathway’ describes the role of KIF3C in colorectal cancer
tumorigenesis and its molecular mechanism. This is an interesting study.
I ask authors to address the following minor comments.
1.      To convincingly establish that KIF3C promotes proliferation and migration through
PI3K/AKT signaling, please conduct a rescue experiment wherein proliferation and migration is
measured after ectopically expressing KIF3C following treatment with PI3K or AKT inhibitor.
2.      Please show higher magnification images of IHC shown in figure 1a (in inset).
3.      Please show median survival and hazard ratio for survival curve shown in figure 1F.
Please review this paper.
user
Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 5 Date: 29 Aug 2024
Reviewer's report:
The manuscript by Yan and coworkers titled ‘KIF3C inhibits the progression and proliferation of
colorectal cancer through PI3K/AKT pathway’ describes the role of KIF3C in colorectal cancer
tumorigenesis and its molecular mechanism. This is an interesting study.
I ask authors to address the following minor comments.
1.      To convincingly establish that KIF3C promotes proliferation and migration through
PI3K/AKT signaling, please conduct a rescue experiment wherein proliferation and migration is
measured after ectopically expressing KIF3C following treatment with PI3K or AKT inhibitor.
2.      Please show higher magnification images of IHC shown in figure 1a (in inset).
3.      Please show median survival and hazard ratio for survival curve shown in figure 1F.
assistant