Reviewer's report
Title:Clinical value of wireless pH-monitoring of gastroesophageal reflux in
children before and after proton pump inhibitors
Version:2Date:21 September 2014
Reviewer: Manuele Furnari
Reviewer's report:
I read with interest the manuscript by Bostrõm et al.
They evaluated the potential benefit of using Bravo system for GERD evaluation
in children. The authors reported Bravo system as safe and tolerable in children
and allows to obtain further information about PPI response due to the availabity
of extra 24h recording.
The manuscript is overall well written, states clearly the aim and provide all the
information the reader may need in order to reproduce and evaluate the variables
investigated.
However, there are a couple of revisions the authors should deal with.
Minor:
1 in the abstract children is mistyped (introduction).
Major:
2 in the results sections the authors reported that only 26 pota had microscopic
esophagitis. I believe this is extremely low incidente. Furthermore, it is markedly
allarming that 26 patients had macroscopic signs of esophagitis and normal
histology.
about Several studies (in adults) reported incidence of ME even among subject
with normal EGDs and MII-pH, and 90-70% of ME among subjects with
esophagitis or proven NERD.
The authors should discussed it and provide reasonable explanation of their
results.
One might be hipothesized that there was not sufficient training among the
pathogists or, more probable, a tendency to over-estimate the endoscopic
findings.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
Reviewer's report
Title:Clinical value of wireless pH-monitoring of gastroesophageal reflux in
children before and after proton pump inhibitors
Version:2Date:21 September 2014
Reviewer: Manuele Furnari
Reviewer's report:
I read with interest the manuscript by Bostrõm et al.
They evaluated the potential benefit of using Bravo system for GERD evaluation
in children. The authors reported Bravo system as safe and tolerable in children
and allows to obtain further information about PPI response due to the availabity
of extra 24h recording.
The manuscript is overall well written, states clearly the aim and provide all the
information the reader may need in order to reproduce and evaluate the variables
investigated.
However, there are a couple of revisions the authors should deal with.
Minor:
1 in the abstract children is mistyped (introduction).
Major:
2 in the results sections the authors reported that only 26 pota had microscopic
esophagitis. I believe this is extremely low incidente. Furthermore, it is markedly
allarming that 26 patients had macroscopic signs of esophagitis and normal
histology.
about Several studies (in adults) reported incidence of ME even among subject
with normal EGDs and MII-pH, and 90-70% of ME among subjects with
esophagitis or proven NERD.
The authors should discussed it and provide reasonable explanation of their
results.
One might be hipothesized that there was not sufficient training among the
pathogists or, more probable, a tendency to over-estimate the endoscopic
findings.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
Please review this paper.
user
Reviewer's report
Title:Clinical value of wireless pH-monitoring of gastroesophageal reflux in
children before and after proton pump inhibitors
Version:2Date:21 September 2014
Reviewer: Manuele Furnari
Reviewer's report:
I read with interest the manuscript by Bostrõm et al.
They evaluated the potential benefit of using Bravo system for GERD evaluation
in children. The authors reported Bravo system as safe and tolerable in children
and allows to obtain further information about PPI response due to the availabity
of extra 24h recording.
The manuscript is overall well written, states clearly the aim and provide all the
information the reader may need in order to reproduce and evaluate the variables
investigated.
However, there are a couple of revisions the authors should deal with.
Minor:
1 in the abstract children is mistyped (introduction).
Major:
2 in the results sections the authors reported that only 26 pota had microscopic
esophagitis. I believe this is extremely low incidente. Furthermore, it is markedly
allarming that 26 patients had macroscopic signs of esophagitis and normal
histology.
about Several studies (in adults) reported incidence of ME even among subject
with normal EGDs and MII-pH, and 90-70% of ME among subjects with
esophagitis or proven NERD.
The authors should discussed it and provide reasonable explanation of their
results.
One might be hipothesized that there was not sufficient training among the
pathogists or, more probable, a tendency to over-estimate the endoscopic
findings.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
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