Title: Accumulation of rare earth elements in human gallstones: a perspective from dietary and
human health
Version: 1 Date: 25 Aug 2024
Reviewer's report:
Comments
The manuscript is of good quality, timely, and highlights an important research study about
REES in gallstone. There are only minor issues with grammar (see track changes file of MS
Word) that have been highlighted in the manuscript and are given below for guidance to the
authors. In-depth analysis of the collected data and evidence-based reasoning are lacking a bit in
this study.  In places, though,  facts borrowed from other authors’ works have been cited instead
of reaching conclusions based on the in-depth analysis of the data collected in this study.
-Line 80: Is it “Countries”?
-Line 104: If it is total digestion (no residue, and clear liquied at the end), provide the appropriate
source (citation/reference) that the method chosen is established in terms of material digestion.
-Line 115: Please provide details of Quality assurance and quality control (QA/QC) as a table
about detection limit, accuracy, precision, etc. to validate your results because it is a health-
related data reporting.
-Line 119: Please provide a source on the validation of the equation of BMI.
-Line 145: This info along with the size and shape of the Gallstone probably belongs to the
“Sampling” section of the manuscript.
-Line 146: Please provide a table about the collected samples (e.g., size, weight, color, shape, etc)
-Line 148: Please provide the percentage sampled population here rather than ‘… most were …”.
-Line 149: If possible tabulae the data as part of supplementary material about the sampled
patients' characteristics as it may have a significant relation to the REEs enrichment or depletion.
-Line 154: What could be the possible reasons for lower values?
-Line 157: Interesting scientific observation. What could be the reason?
-Line 168: The first four sentences of the discussion section are presented as findings of other
works. Please engage in your opinion based on an analysis of your data and then cite the source
of others' works to agree or disagree.
-Line 22: Sorry but too often there is use of the word ‘obvious’ in the manuscript. Try to change
it for better readability.
-Line 318: Is it “coulping”?
Title: Accumulation of rare earth elements in human gallstones: a perspective from dietary and
human health
Version: 1 Date: 25 Aug 2024
Reviewer's report:
Comments
The manuscript is of good quality, timely, and highlights an important research study about
REES in gallstone. There are only minor issues with grammar (see track changes file of MS
Word) that have been highlighted in the manuscript and are given below for guidance to the
authors. In-depth analysis of the collected data and evidence-based reasoning are lacking a bit in
this study.  In places, though,  facts borrowed from other authors’ works have been cited instead
of reaching conclusions based on the in-depth analysis of the data collected in this study.
-Line 80: Is it “Countries”?
-Line 104: If it is total digestion (no residue, and clear liquied at the end), provide the appropriate
source (citation/reference) that the method chosen is established in terms of material digestion.
-Line 115: Please provide details of Quality assurance and quality control (QA/QC) as a table
about detection limit, accuracy, precision, etc. to validate your results because it is a health-
related data reporting.
-Line 119: Please provide a source on the validation of the equation of BMI.
-Line 145: This info along with the size and shape of the Gallstone probably belongs to the
“Sampling” section of the manuscript.
-Line 146: Please provide a table about the collected samples (e.g., size, weight, color, shape, etc)
-Line 148: Please provide the percentage sampled population here rather than ‘… most were …”.
-Line 149: If possible tabulae the data as part of supplementary material about the sampled
patients' characteristics as it may have a significant relation to the REEs enrichment or depletion.
-Line 154: What could be the possible reasons for lower values?
-Line 157: Interesting scientific observation. What could be the reason?
-Line 168: The first four sentences of the discussion section are presented as findings of other
works. Please engage in your opinion based on an analysis of your data and then cite the source
of others' works to agree or disagree.
-Line 22: Sorry but too often there is use of the word ‘obvious’ in the manuscript. Try to change
it for better readability.
-Line 318: Is it “coulping”?
Please review this paper.
user
Title: Accumulation of rare earth elements in human gallstones: a perspective from dietary and
human health
Version: 1 Date: 25 Aug 2024
Reviewer's report:
Comments
The manuscript is of good quality, timely, and highlights an important research study about
REES in gallstone. There are only minor issues with grammar (see track changes file of MS
Word) that have been highlighted in the manuscript and are given below for guidance to the
authors. In-depth analysis of the collected data and evidence-based reasoning are lacking a bit in
this study.  In places, though,  facts borrowed from other authors’ works have been cited instead
of reaching conclusions based on the in-depth analysis of the data collected in this study.
-Line 80: Is it “Countries”?
-Line 104: If it is total digestion (no residue, and clear liquied at the end), provide the appropriate
source (citation/reference) that the method chosen is established in terms of material digestion.
-Line 115: Please provide details of Quality assurance and quality control (QA/QC) as a table
about detection limit, accuracy, precision, etc. to validate your results because it is a health-
related data reporting.
-Line 119: Please provide a source on the validation of the equation of BMI.
-Line 145: This info along with the size and shape of the Gallstone probably belongs to the
“Sampling” section of the manuscript.
-Line 146: Please provide a table about the collected samples (e.g., size, weight, color, shape, etc)
-Line 148: Please provide the percentage sampled population here rather than ‘… most were …”.
-Line 149: If possible tabulae the data as part of supplementary material about the sampled
patients' characteristics as it may have a significant relation to the REEs enrichment or depletion.
-Line 154: What could be the possible reasons for lower values?
-Line 157: Interesting scientific observation. What could be the reason?
-Line 168: The first four sentences of the discussion section are presented as findings of other
works. Please engage in your opinion based on an analysis of your data and then cite the source
of others' works to agree or disagree.
-Line 22: Sorry but too often there is use of the word ‘obvious’ in the manuscript. Try to change
it for better readability.
-Line 318: Is it “coulping”?
assistant