Title: Study on Clinical Characteristics and Related Factors of Schizophrenia Patients with
Intestinal Obstruction Running title: Schizophrenia with Intestinal Obstruction
Version: 1 Date: 16 Oct 2021
Reviewer's report:
Title: Study on Clinical Characteristics and Related Factors of Schizophrenia Patients with
Intestinal Obstruction
This is a retrospective study to examine the clinical characteristics and related risk factors of
schizophrenia patients with intestinal obstruction.
In background section
1. The authors did not review any article related to intestinal obstruction in schizophrenia.
Therefore, the context for the research question addressing in this study is not clear.
In methods section
1. There are many reports of intestinal obstruction following treatment with combination of
antipsychotics and anticholinergic drugs in the literatures. However, the authors did not include
any medications in the analysis, such as antipsychotics, anticholinergic agents which could also
increase the risk of intestinal obstruction.
2. The authors did not provide the rationales for selection of the main observation indicators and
the definition they selected. For example, age #60 years old and #60 years old; Hospital stay
#90 days and #90 days; Course of disease#5 years and #5 years; Visiting time#24 hours and
#24 hours in table 1.
3. According to the definition, the incidence rate is the number of new cases within a time period
(the numerator) as a proportion of the number of people at risk for the disease (the denominator).
However, the authors did not mention the time period.
In results section
1. The authors did not provide the whole samples’ demographic characteristics, such as average
age.
Title: Study on Clinical Characteristics and Related Factors of Schizophrenia Patients with
Intestinal Obstruction Running title: Schizophrenia with Intestinal Obstruction
Version: 1 Date: 16 Oct 2021
Reviewer's report:
Title: Study on Clinical Characteristics and Related Factors of Schizophrenia Patients with
Intestinal Obstruction
This is a retrospective study to examine the clinical characteristics and related risk factors of
schizophrenia patients with intestinal obstruction.
In background section
1. The authors did not review any article related to intestinal obstruction in schizophrenia.
Therefore, the context for the research question addressing in this study is not clear.
In methods section
1. There are many reports of intestinal obstruction following treatment with combination of
antipsychotics and anticholinergic drugs in the literatures. However, the authors did not include
any medications in the analysis, such as antipsychotics, anticholinergic agents which could also
increase the risk of intestinal obstruction.
2. The authors did not provide the rationales for selection of the main observation indicators and
the definition they selected. For example, age #60 years old and #60 years old; Hospital stay
#90 days and #90 days; Course of disease#5 years and #5 years; Visiting time#24 hours and
#24 hours in table 1.
3. According to the definition, the incidence rate is the number of new cases within a time period
(the numerator) as a proportion of the number of people at risk for the disease (the denominator).
However, the authors did not mention the time period.
In results section
1. The authors did not provide the whole samples’ demographic characteristics, such as average
age.
Please review this paper.
user
Title: Study on Clinical Characteristics and Related Factors of Schizophrenia Patients with
Intestinal Obstruction Running title: Schizophrenia with Intestinal Obstruction
Version: 1 Date: 16 Oct 2021
Reviewer's report:
Title: Study on Clinical Characteristics and Related Factors of Schizophrenia Patients with
Intestinal Obstruction
This is a retrospective study to examine the clinical characteristics and related risk factors of
schizophrenia patients with intestinal obstruction.
In background section
1. The authors did not review any article related to intestinal obstruction in schizophrenia.
Therefore, the context for the research question addressing in this study is not clear.
In methods section
1. There are many reports of intestinal obstruction following treatment with combination of
antipsychotics and anticholinergic drugs in the literatures. However, the authors did not include
any medications in the analysis, such as antipsychotics, anticholinergic agents which could also
increase the risk of intestinal obstruction.
2. The authors did not provide the rationales for selection of the main observation indicators and
the definition they selected. For example, age #60 years old and #60 years old; Hospital stay
#90 days and #90 days; Course of disease#5 years and #5 years; Visiting time#24 hours and
#24 hours in table 1.
3. According to the definition, the incidence rate is the number of new cases within a time period
(the numerator) as a proportion of the number of people at risk for the disease (the denominator).
However, the authors did not mention the time period.
In results section
1. The authors did not provide the whole samples’ demographic characteristics, such as average
age.
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