Reviewer's report
Title:Oral bisphosphonates do not increase the risk of severe upper
gastrointestinal complications: a nested case-control study
Version: 1Date:16 May 2013
Reviewer: Olivier Lamy
Reviewer's report:
The design of these nested case-control study is interesting. Only patients with
severe fractures were included. These patients have co-morbidities and take
many medications. The number of patients who were hospitalized and who take
bisphosphonates were very low, only 38. It is difficult to give any conclusion with
this small number. An important bias is the number of patients taking
gastroprotective agents in the “case patients”.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Oral bisphosphonates do not increase the risk of severe upper
gastrointestinal complications: a nested case-control study
Version: 1Date:16 May 2013
Reviewer: Olivier Lamy
Reviewer's report:
The design of these nested case-control study is interesting. Only patients with
severe fractures were included. These patients have co-morbidities and take
many medications. The number of patients who were hospitalized and who take
bisphosphonates were very low, only 38. It is difficult to give any conclusion with
this small number. An important bias is the number of patients taking
gastroprotective agents in the “case patients”.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Oral bisphosphonates do not increase the risk of severe upper
gastrointestinal complications: a nested case-control study
Version: 1Date:16 May 2013
Reviewer: Olivier Lamy
Reviewer's report:
The design of these nested case-control study is interesting. Only patients with
severe fractures were included. These patients have co-morbidities and take
many medications. The number of patients who were hospitalized and who take
bisphosphonates were very low, only 38. It is difficult to give any conclusion with
this small number. An important bias is the number of patients taking
gastroprotective agents in the “case patients”.
Declaration of competing interests:
I declare that I have no competing interests
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