Title: Red cell distribution width as a potential new biomarker to predict the clinical severity
of acute diverticulitis
Version: 1 Date: 06 Mar 2025
Reviewer's report:
Thank you for allowing me to review the manuscript from Melek Yalcin Koc et al, entitled
“Red cell distribution width as a potential new biomarker to predict the clinical severity of acute
diverticulitis”.
Congratulation to the authors for their remarkable work. In my opinion, the subject is of interest
but the manuscript in this present form is too long and too difficult to read. It should be shorten
and the results should focus on the objective (compare the diverticultis).
Abstract : OK
Introduction: ok
MM: were all the acute diverticulitis confirmed by colonoscopy? This is surprising because the
colonoscopy in this context is at risk for perforation. Is this a routine examination in you hospital?
How was chosen the control group? Who are the patients ?
Why did the authors choose to include a control group? The objective is to investigate the
relationship between RDW other inflammatory markers and some clinical features with the
presence, and clinical and radiological severity of acute diverticulitis. I am not sure that this is
necessary (the control group should be the patient that have no severe diverticulitis)
Results:
The first part of the results does not add something to the literature (older age, WBC and CRP
are associated with the risk of diverticulitis)
I would suggest to reduce the result section and limit to the comparisons of severe diverticulitis
and the need for surgery.
The need for surgery should be defined (immediate surgery or failure of conservative
management)
I would be interested in having the results of creatininemia (influence of renal failure on RDW)
Discussion
Should be shorten and focused on the results.
Please explain why the RDW would be increased in patients with diverticulitis requiring
surgery? What should be the pathophysiology?
Title: Red cell distribution width as a potential new biomarker to predict the clinical severity
of acute diverticulitis
Version: 1 Date: 06 Mar 2025
Reviewer's report:
Thank you for allowing me to review the manuscript from Melek Yalcin Koc et al, entitled
“Red cell distribution width as a potential new biomarker to predict the clinical severity of acute
diverticulitis”.
Congratulation to the authors for their remarkable work. In my opinion, the subject is of interest
but the manuscript in this present form is too long and too difficult to read. It should be shorten
and the results should focus on the objective (compare the diverticultis).
Abstract : OK
Introduction: ok
MM: were all the acute diverticulitis confirmed by colonoscopy? This is surprising because the
colonoscopy in this context is at risk for perforation. Is this a routine examination in you hospital?
How was chosen the control group? Who are the patients ?
Why did the authors choose to include a control group? The objective is to investigate the
relationship between RDW other inflammatory markers and some clinical features with the
presence, and clinical and radiological severity of acute diverticulitis. I am not sure that this is
necessary (the control group should be the patient that have no severe diverticulitis)
Results:
The first part of the results does not add something to the literature (older age, WBC and CRP
are associated with the risk of diverticulitis)
I would suggest to reduce the result section and limit to the comparisons of severe diverticulitis
and the need for surgery.
The need for surgery should be defined (immediate surgery or failure of conservative
management)
I would be interested in having the results of creatininemia (influence of renal failure on RDW)
Discussion
Should be shorten and focused on the results.
Please explain why the RDW would be increased in patients with diverticulitis requiring
surgery? What should be the pathophysiology?
Please review this paper.
user
Title: Red cell distribution width as a potential new biomarker to predict the clinical severity
of acute diverticulitis
Version: 1 Date: 06 Mar 2025
Reviewer's report:
Thank you for allowing me to review the manuscript from Melek Yalcin Koc et al, entitled
“Red cell distribution width as a potential new biomarker to predict the clinical severity of acute
diverticulitis”.
Congratulation to the authors for their remarkable work. In my opinion, the subject is of interest
but the manuscript in this present form is too long and too difficult to read. It should be shorten
and the results should focus on the objective (compare the diverticultis).
Abstract : OK
Introduction: ok
MM: were all the acute diverticulitis confirmed by colonoscopy? This is surprising because the
colonoscopy in this context is at risk for perforation. Is this a routine examination in you hospital?
How was chosen the control group? Who are the patients ?
Why did the authors choose to include a control group? The objective is to investigate the
relationship between RDW other inflammatory markers and some clinical features with the
presence, and clinical and radiological severity of acute diverticulitis. I am not sure that this is
necessary (the control group should be the patient that have no severe diverticulitis)
Results:
The first part of the results does not add something to the literature (older age, WBC and CRP
are associated with the risk of diverticulitis)
I would suggest to reduce the result section and limit to the comparisons of severe diverticulitis
and the need for surgery.
The need for surgery should be defined (immediate surgery or failure of conservative
management)
I would be interested in having the results of creatininemia (influence of renal failure on RDW)
Discussion
Should be shorten and focused on the results.
Please explain why the RDW would be increased in patients with diverticulitis requiring
surgery? What should be the pathophysiology?
assistant