Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 0 Date: 04 Aug 2024
Reviewer:  Semra Demirli Atici
Reviewer's report:
Today, the most common cause of emergency surgery is still acute appendicitis. Therefore,
prospective studies such as these are important.
How did the authors diagnose acute appendicitis? Physical examination? Was the diagnosis
made with imaging support? Not specified in this article.
Were the patients diagnosed with acute appendicitis only with physical examination and 5HIAA
test without any imaging? If imaging was performed, is there a superiority or correlation between
the perforated appendicitis rate here and the 5HIAA test?
Any pregnant patients included in the study?
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 0 Date: 04 Aug 2024
Reviewer:  Semra Demirli Atici
Reviewer's report:
Today, the most common cause of emergency surgery is still acute appendicitis. Therefore,
prospective studies such as these are important.
How did the authors diagnose acute appendicitis? Physical examination? Was the diagnosis
made with imaging support? Not specified in this article.
Were the patients diagnosed with acute appendicitis only with physical examination and 5HIAA
test without any imaging? If imaging was performed, is there a superiority or correlation between
the perforated appendicitis rate here and the 5HIAA test?
Any pregnant patients included in the study?
Please review this paper.
user
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 0 Date: 04 Aug 2024
Reviewer:  Semra Demirli Atici
Reviewer's report:
Today, the most common cause of emergency surgery is still acute appendicitis. Therefore,
prospective studies such as these are important.
How did the authors diagnose acute appendicitis? Physical examination? Was the diagnosis
made with imaging support? Not specified in this article.
Were the patients diagnosed with acute appendicitis only with physical examination and 5HIAA
test without any imaging? If imaging was performed, is there a superiority or correlation between
the perforated appendicitis rate here and the 5HIAA test?
Any pregnant patients included in the study?
assistant