Title: Controlling Nutritional Status (CONUT) score as a predictive marker for short-term
complications following gastrectomy of gastric cancer: a retrospective study
Version: 2 Date: 11 Jan 2021
Reviewer's report:
This study has a large number of cases, which is a good point. However, there are some concerns
about statistical analysis and interpretation that should be addressed.
In the multivariate analysis in Table 2, it should be explained in the statistical analysis chapter
how the variables included in the model were chosen. It seems that there are some variables that
are significant in univariate analysis but excluded in multivariate analysis.
Also, since logistic regression is not mentioned in the statistical analysis, all the analyses
conducted in the paper should be mentioned in the statistical analysis.
The authors performed ROC analysis of CONUT, ALB, PNI, and PLR, all of which have an
AUC of about 0.5, which does not seem to have predictive ability.
This may mean that there is an association with the outcome but no predictive ability.
The results of ROC analysis should not be included in the paper because it may lead to
misleading.
In Table 3, the threshold of CONUT is set to 2 for two-group comparison, but how was it
determined?How was it determined? Youden index or (0,1)-closest method? In addition, it hould
be considered what CONUT=2 means clinically.
Title: Controlling Nutritional Status (CONUT) score as a predictive marker for short-term
complications following gastrectomy of gastric cancer: a retrospective study
Version: 2 Date: 11 Jan 2021
Reviewer's report:
This study has a large number of cases, which is a good point. However, there are some concerns
about statistical analysis and interpretation that should be addressed.
In the multivariate analysis in Table 2, it should be explained in the statistical analysis chapter
how the variables included in the model were chosen. It seems that there are some variables that
are significant in univariate analysis but excluded in multivariate analysis.
Also, since logistic regression is not mentioned in the statistical analysis, all the analyses
conducted in the paper should be mentioned in the statistical analysis.
The authors performed ROC analysis of CONUT, ALB, PNI, and PLR, all of which have an
AUC of about 0.5, which does not seem to have predictive ability.
This may mean that there is an association with the outcome but no predictive ability.
The results of ROC analysis should not be included in the paper because it may lead to
misleading.
In Table 3, the threshold of CONUT is set to 2 for two-group comparison, but how was it
determined?How was it determined? Youden index or (0,1)-closest method? In addition, it hould
be considered what CONUT=2 means clinically.
Please review this paper.
user
Title: Controlling Nutritional Status (CONUT) score as a predictive marker for short-term
complications following gastrectomy of gastric cancer: a retrospective study
Version: 2 Date: 11 Jan 2021
Reviewer's report:
This study has a large number of cases, which is a good point. However, there are some concerns
about statistical analysis and interpretation that should be addressed.
In the multivariate analysis in Table 2, it should be explained in the statistical analysis chapter
how the variables included in the model were chosen. It seems that there are some variables that
are significant in univariate analysis but excluded in multivariate analysis.
Also, since logistic regression is not mentioned in the statistical analysis, all the analyses
conducted in the paper should be mentioned in the statistical analysis.
The authors performed ROC analysis of CONUT, ALB, PNI, and PLR, all of which have an
AUC of about 0.5, which does not seem to have predictive ability.
This may mean that there is an association with the outcome but no predictive ability.
The results of ROC analysis should not be included in the paper because it may lead to
misleading.
In Table 3, the threshold of CONUT is set to 2 for two-group comparison, but how was it
determined?How was it determined? Youden index or (0,1)-closest method? In addition, it hould
be considered what CONUT=2 means clinically.
assistant