Reviewer's report
Title:Predicting incident fatty liver at 4.37 year follow up, using simple
cardio-metabolic risk factors at baseline
Version: 1Date:18 May 2012
Reviewer: JUDE OBEN
Reviewer's report:
This is an interesting study describing the utility of easily measurable liver and
laboratory parameters in the diagnosis of NAFLD. The study is of importance
give the rising rates of obesity and in parallel rates of NAFLD. The study
deserves to be read by the general hepatology and gastroenterology
communities.
I am however, sceptical as to its utility given the ready availability and reasonable
cost of first line imaging modalities – ie USS in most healthcare systems where
NAFLD is a burgeoning problem, although the sensitivity of USS is an issue. A
more clinically useful study would have been the comparison of factors with a
more sensitive imaging modality such as MRS, but as the authors acknowledge
such a study would have been prohibitively expensive. An even more useful
study would have been the comparison of factors that allowed avoidance of a
staging liver biopsy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Reviewer's report
Title:Predicting incident fatty liver at 4.37 year follow up, using simple
cardio-metabolic risk factors at baseline
Version: 1Date:18 May 2012
Reviewer: JUDE OBEN
Reviewer's report:
This is an interesting study describing the utility of easily measurable liver and
laboratory parameters in the diagnosis of NAFLD. The study is of importance
give the rising rates of obesity and in parallel rates of NAFLD. The study
deserves to be read by the general hepatology and gastroenterology
communities.
I am however, sceptical as to its utility given the ready availability and reasonable
cost of first line imaging modalities – ie USS in most healthcare systems where
NAFLD is a burgeoning problem, although the sensitivity of USS is an issue. A
more clinically useful study would have been the comparison of factors with a
more sensitive imaging modality such as MRS, but as the authors acknowledge
such a study would have been prohibitively expensive. An even more useful
study would have been the comparison of factors that allowed avoidance of a
staging liver biopsy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Please review this paper.
user
Reviewer's report
Title:Predicting incident fatty liver at 4.37 year follow up, using simple
cardio-metabolic risk factors at baseline
Version: 1Date:18 May 2012
Reviewer: JUDE OBEN
Reviewer's report:
This is an interesting study describing the utility of easily measurable liver and
laboratory parameters in the diagnosis of NAFLD. The study is of importance
give the rising rates of obesity and in parallel rates of NAFLD. The study
deserves to be read by the general hepatology and gastroenterology
communities.
I am however, sceptical as to its utility given the ready availability and reasonable
cost of first line imaging modalities – ie USS in most healthcare systems where
NAFLD is a burgeoning problem, although the sensitivity of USS is an issue. A
more clinically useful study would have been the comparison of factors with a
more sensitive imaging modality such as MRS, but as the authors acknowledge
such a study would have been prohibitively expensive. An even more useful
study would have been the comparison of factors that allowed avoidance of a
staging liver biopsy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
assistant