Title: A novel imaging index for predicting adverse progression in acute-on-chronic liver failure
related to hepatitis B virus: the low erector spine index
Version: 4 Date: 30 Aug 2023
Reviewer:  Liyan Dong
Reviewer's report:
The authors should add some pathogenesis of the erector spine index affecting the progression
of HBV-ACLF in the “Discussion” section.
As you said, the patients in this study were treated with different antiviral drugs, which may
effect the outcomes of the HBV-ACLF, how to adjust such confounding factor?
The authors should check the data carefully. For example, in the “RESULTS” part of
“ABSTRACT” section, the authors said “patients with a low ESI (#12.05 cm2/m2) had higher
mortality than those with a high ESI (>12.05 cm2/m2)”, but in the following tables, the patients
with a low ESI was defined as ESI<12.05 cm2/m2, and the patients with a high ESI was defined
as ESI#12.05 cm2/m2.
The authors should check the data in “Table 2”.
The authors should carefully check the use of abbreviations in the manuscript. Use the full
name at its first occurrence, and then use its abbreviation. For example, in the “General
patient characteristics” part of “RESULTS” section, the authors said “The in-hospital infections
primarily included spontaneous bacterial peritonitis (SBP)…”, where the words “spontaneous
bacterial peritonitis (SBP)” should be revised as “SBP”. The same mistakes can be easily seen.
In the “ DISCUSSION” section, the authors said “In addition, it also impacted mortality related
to treatment in patients with HCC, significant liver fibrosis and, and adverse posttransplant
outcomes”, where the first “and” should be deleted.
Title: A novel imaging index for predicting adverse progression in acute-on-chronic liver failure
related to hepatitis B virus: the low erector spine index
Version: 4 Date: 30 Aug 2023
Reviewer:  Liyan Dong
Reviewer's report:
The authors should add some pathogenesis of the erector spine index affecting the progression
of HBV-ACLF in the “Discussion” section.
As you said, the patients in this study were treated with different antiviral drugs, which may
effect the outcomes of the HBV-ACLF, how to adjust such confounding factor?
The authors should check the data carefully. For example, in the “RESULTS” part of
“ABSTRACT” section, the authors said “patients with a low ESI (#12.05 cm2/m2) had higher
mortality than those with a high ESI (>12.05 cm2/m2)”, but in the following tables, the patients
with a low ESI was defined as ESI<12.05 cm2/m2, and the patients with a high ESI was defined
as ESI#12.05 cm2/m2.
The authors should check the data in “Table 2”.
The authors should carefully check the use of abbreviations in the manuscript. Use the full
name at its first occurrence, and then use its abbreviation. For example, in the “General
patient characteristics” part of “RESULTS” section, the authors said “The in-hospital infections
primarily included spontaneous bacterial peritonitis (SBP)…”, where the words “spontaneous
bacterial peritonitis (SBP)” should be revised as “SBP”. The same mistakes can be easily seen.
In the “ DISCUSSION” section, the authors said “In addition, it also impacted mortality related
to treatment in patients with HCC, significant liver fibrosis and, and adverse posttransplant
outcomes”, where the first “and” should be deleted.
Please review this paper.
user
Title: A novel imaging index for predicting adverse progression in acute-on-chronic liver failure
related to hepatitis B virus: the low erector spine index
Version: 4 Date: 30 Aug 2023
Reviewer:  Liyan Dong
Reviewer's report:
The authors should add some pathogenesis of the erector spine index affecting the progression
of HBV-ACLF in the “Discussion” section.
As you said, the patients in this study were treated with different antiviral drugs, which may
effect the outcomes of the HBV-ACLF, how to adjust such confounding factor?
The authors should check the data carefully. For example, in the “RESULTS” part of
“ABSTRACT” section, the authors said “patients with a low ESI (#12.05 cm2/m2) had higher
mortality than those with a high ESI (>12.05 cm2/m2)”, but in the following tables, the patients
with a low ESI was defined as ESI<12.05 cm2/m2, and the patients with a high ESI was defined
as ESI#12.05 cm2/m2.
The authors should check the data in “Table 2”.
The authors should carefully check the use of abbreviations in the manuscript. Use the full
name at its first occurrence, and then use its abbreviation. For example, in the “General
patient characteristics” part of “RESULTS” section, the authors said “The in-hospital infections
primarily included spontaneous bacterial peritonitis (SBP)…”, where the words “spontaneous
bacterial peritonitis (SBP)” should be revised as “SBP”. The same mistakes can be easily seen.
In the “ DISCUSSION” section, the authors said “In addition, it also impacted mortality related
to treatment in patients with HCC, significant liver fibrosis and, and adverse posttransplant
outcomes”, where the first “and” should be deleted.
assistant