Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 7 Date: 24 Sep 2024
Reviewer's report:
Dear Editor,
I should first thank for inviting me as potential reviewer to read and comment on paper entitled
‘’Celiac disease autoimmunity among Nigerian children and adolescents with type 1 diabetes
mellitus’’.
In the current study, the authors aimed to investigate the prevalence and pattern of CD
autoimmunity in Nigerian children and adolescents diagnosed with T1DM.
The main title accurately reflects the major topic and content of the study.
The abstract summarizes and reflects the work described in the manuscript. Also, the abstract
presents the significant points related to the background, objectives, materials and methods,
results and conclusions.
The materials and methods sufficiently described for the results and conclusions that are
presented in the preceding sections. The study type and design were defined in the section of
the materials and methods. Figures and tables are sufficient and well-organized. So, the section
materials and methods is adequate.
The statistical methods used are appropriate.
The section of the discussion is well organized. The conclusions are drawn appropriately
supported by the literature. The manuscript adequately describes the background, present
status and significance of the study. The manuscript interprets the findings adequately and
appropriately, highlighting the key points clearly.
I think that it will contribute to the literature. I have some minor criticisms.
- In the current study, the authors found a 5.8% prevalence of CD in Nigerian children and
adolescents with TIDM. The similar result 4.4% was detected in recent study conducted in
Turkey (Iran J Pediatr 2020;30:e97306). Also, the similar symptoms and results were detected in
celiac patients in that study. If the recent published article called ‘’Prevalence of Celiac Disease
in Children with Type 1 Diabetes Mellitus in the South of Turkey’’ are cited, the manuscript
would be better.
- In the manuscript, HLA aassociation of celiac disease and type 1 DM is stated but no reference
is cited. The recent published references about that for example ‘’ Celiac disease in children:
A review of the literature. World J Clin Pediatr. 2021 Jul 9;10(4):53-71’’ and ‘’ Frequency of
celiac disease and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with
celiac disease. World J Clin Pediatr 2022;11: 351-359‘’ is cited, the manuscript would be better.
- There is no the references at the following paragraph. Please add relevant references about
autoimmune disease and celiac disease for example to the end of the sentence for example ‘’ Eur J
Rheumatol. 2019 Apr 22;6(3):142-145. Serological screening for celiac disease in children with
systemic lupus erythematosus’’ and  ‘’Arab J Gastroenterol. 2019 Jun;20(2):95-98. Serological
screening for coeliac disease in patients with juvenile idiopathic arthritis’’.
‘’The prevalence of celiac disease in the general population is about 1%. However, it is more
common in specific groups, such as first-degree relatives of affected persons, individuals with
Type 1 Diabetes Mellitus (T1DM), chronic diarrhea, failure to thrive, Down syndrome, Turner
syndrome, autoimmune thyroiditis, selective IgA deficiency, and William syndrome’’.
Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 7 Date: 24 Sep 2024
Reviewer's report:
Dear Editor,
I should first thank for inviting me as potential reviewer to read and comment on paper entitled
‘’Celiac disease autoimmunity among Nigerian children and adolescents with type 1 diabetes
mellitus’’.
In the current study, the authors aimed to investigate the prevalence and pattern of CD
autoimmunity in Nigerian children and adolescents diagnosed with T1DM.
The main title accurately reflects the major topic and content of the study.
The abstract summarizes and reflects the work described in the manuscript. Also, the abstract
presents the significant points related to the background, objectives, materials and methods,
results and conclusions.
The materials and methods sufficiently described for the results and conclusions that are
presented in the preceding sections. The study type and design were defined in the section of
the materials and methods. Figures and tables are sufficient and well-organized. So, the section
materials and methods is adequate.
The statistical methods used are appropriate.
The section of the discussion is well organized. The conclusions are drawn appropriately
supported by the literature. The manuscript adequately describes the background, present
status and significance of the study. The manuscript interprets the findings adequately and
appropriately, highlighting the key points clearly.
I think that it will contribute to the literature. I have some minor criticisms.
- In the current study, the authors found a 5.8% prevalence of CD in Nigerian children and
adolescents with TIDM. The similar result 4.4% was detected in recent study conducted in
Turkey (Iran J Pediatr 2020;30:e97306). Also, the similar symptoms and results were detected in
celiac patients in that study. If the recent published article called ‘’Prevalence of Celiac Disease
in Children with Type 1 Diabetes Mellitus in the South of Turkey’’ are cited, the manuscript
would be better.
- In the manuscript, HLA aassociation of celiac disease and type 1 DM is stated but no reference
is cited. The recent published references about that for example ‘’ Celiac disease in children:
A review of the literature. World J Clin Pediatr. 2021 Jul 9;10(4):53-71’’ and ‘’ Frequency of
celiac disease and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with
celiac disease. World J Clin Pediatr 2022;11: 351-359‘’ is cited, the manuscript would be better.
- There is no the references at the following paragraph. Please add relevant references about
autoimmune disease and celiac disease for example to the end of the sentence for example ‘’ Eur J
Rheumatol. 2019 Apr 22;6(3):142-145. Serological screening for celiac disease in children with
systemic lupus erythematosus’’ and  ‘’Arab J Gastroenterol. 2019 Jun;20(2):95-98. Serological
screening for coeliac disease in patients with juvenile idiopathic arthritis’’.
‘’The prevalence of celiac disease in the general population is about 1%. However, it is more
common in specific groups, such as first-degree relatives of affected persons, individuals with
Type 1 Diabetes Mellitus (T1DM), chronic diarrhea, failure to thrive, Down syndrome, Turner
syndrome, autoimmune thyroiditis, selective IgA deficiency, and William syndrome’’.
Please review this paper.
user
Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 7 Date: 24 Sep 2024
Reviewer's report:
Dear Editor,
I should first thank for inviting me as potential reviewer to read and comment on paper entitled
‘’Celiac disease autoimmunity among Nigerian children and adolescents with type 1 diabetes
mellitus’’.
In the current study, the authors aimed to investigate the prevalence and pattern of CD
autoimmunity in Nigerian children and adolescents diagnosed with T1DM.
The main title accurately reflects the major topic and content of the study.
The abstract summarizes and reflects the work described in the manuscript. Also, the abstract
presents the significant points related to the background, objectives, materials and methods,
results and conclusions.
The materials and methods sufficiently described for the results and conclusions that are
presented in the preceding sections. The study type and design were defined in the section of
the materials and methods. Figures and tables are sufficient and well-organized. So, the section
materials and methods is adequate.
The statistical methods used are appropriate.
The section of the discussion is well organized. The conclusions are drawn appropriately
supported by the literature. The manuscript adequately describes the background, present
status and significance of the study. The manuscript interprets the findings adequately and
appropriately, highlighting the key points clearly.
I think that it will contribute to the literature. I have some minor criticisms.
- In the current study, the authors found a 5.8% prevalence of CD in Nigerian children and
adolescents with TIDM. The similar result 4.4% was detected in recent study conducted in
Turkey (Iran J Pediatr 2020;30:e97306). Also, the similar symptoms and results were detected in
celiac patients in that study. If the recent published article called ‘’Prevalence of Celiac Disease
in Children with Type 1 Diabetes Mellitus in the South of Turkey’’ are cited, the manuscript
would be better.
- In the manuscript, HLA aassociation of celiac disease and type 1 DM is stated but no reference
is cited. The recent published references about that for example ‘’ Celiac disease in children:
A review of the literature. World J Clin Pediatr. 2021 Jul 9;10(4):53-71’’ and ‘’ Frequency of
celiac disease and distribution of HLA-DQ2/DQ8 haplotypes among siblings of children with
celiac disease. World J Clin Pediatr 2022;11: 351-359‘’ is cited, the manuscript would be better.
- There is no the references at the following paragraph. Please add relevant references about
autoimmune disease and celiac disease for example to the end of the sentence for example ‘’ Eur J
Rheumatol. 2019 Apr 22;6(3):142-145. Serological screening for celiac disease in children with
systemic lupus erythematosus’’ and  ‘’Arab J Gastroenterol. 2019 Jun;20(2):95-98. Serological
screening for coeliac disease in patients with juvenile idiopathic arthritis’’.
‘’The prevalence of celiac disease in the general population is about 1%. However, it is more
common in specific groups, such as first-degree relatives of affected persons, individuals with
Type 1 Diabetes Mellitus (T1DM), chronic diarrhea, failure to thrive, Down syndrome, Turner
syndrome, autoimmune thyroiditis, selective IgA deficiency, and William syndrome’’.
assistant