Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 3 Date: 26 Nov 2023
Reviewer's report:
Dear authors, the title of study is novel and practical. Thanks for your complete explanations in
the text. However, the conclusion beside the result of  data analysis need to review and completed
regarding these points:
1- Please replace the word "relationship" instead of the word "correlation".
2- Please explain how acid suppressing drugs could reduce stress level?
3- The readers can not find " how many of your patients had functional dyspepsia, GERD, and
overlap of FD with GERD. Please consider the recorded data, what is the indication for prolong
consumption of acid lowering agents in your participants?
4-Please clarify about why you mentioned a general term of  acid lowering agent in your study;
e.g., based on small sample  size you can not address the type of acid lowering agent(PPI,
H2RB, ...)
5- Please include or exclude other confounding factors such as any antibiotic and/or probiotic/
any other supplements, smoking, and alcohol consumption in your study.
Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 3 Date: 26 Nov 2023
Reviewer's report:
Dear authors, the title of study is novel and practical. Thanks for your complete explanations in
the text. However, the conclusion beside the result of  data analysis need to review and completed
regarding these points:
1- Please replace the word "relationship" instead of the word "correlation".
2- Please explain how acid suppressing drugs could reduce stress level?
3- The readers can not find " how many of your patients had functional dyspepsia, GERD, and
overlap of FD with GERD. Please consider the recorded data, what is the indication for prolong
consumption of acid lowering agents in your participants?
4-Please clarify about why you mentioned a general term of  acid lowering agent in your study;
e.g., based on small sample  size you can not address the type of acid lowering agent(PPI,
H2RB, ...)
5- Please include or exclude other confounding factors such as any antibiotic and/or probiotic/
any other supplements, smoking, and alcohol consumption in your study.
Please review this paper.
user
Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 3 Date: 26 Nov 2023
Reviewer's report:
Dear authors, the title of study is novel and practical. Thanks for your complete explanations in
the text. However, the conclusion beside the result of  data analysis need to review and completed
regarding these points:
1- Please replace the word "relationship" instead of the word "correlation".
2- Please explain how acid suppressing drugs could reduce stress level?
3- The readers can not find " how many of your patients had functional dyspepsia, GERD, and
overlap of FD with GERD. Please consider the recorded data, what is the indication for prolong
consumption of acid lowering agents in your participants?
4-Please clarify about why you mentioned a general term of  acid lowering agent in your study;
e.g., based on small sample  size you can not address the type of acid lowering agent(PPI,
H2RB, ...)
5- Please include or exclude other confounding factors such as any antibiotic and/or probiotic/
any other supplements, smoking, and alcohol consumption in your study.
assistant