Reviewer's report
Title:Colon Capsule Endoscopy compared to Conventional Colonoscopy under
routine screening conditions
Version: 2Date:28 January 2010
Reviewer: Andre Van Gossum
Reviewer's report:
The authors report the results of a study that compared colon capsule and optical
colonoscopy in a CRC screening population. They describe a low sensitivity for
colon capsule but a high negative predictive value. They also report a low rate of
complete excretion (64%) and a low percentage of good colon prep.
General remarks
- The number of patients included in this trial designed for a screening procedure
is extremely low.
- As it is mentioned by the authors, the excretion rate and the colon cleanliness
were low. This is probably due to the modification of the colon prep. That shows
the importance of the timing of the procedure.
- Why the authors did use a 3 point scale and not the 4 point as it has been
described ?
- Results : the authors report several findings that were detected on colon
capsule and not on colonoscopy. That could be also false negative of
colonoscopy. It is a pity that a second look colonoscopy was not designed at
least for patients with the so-called significant polyps. The results are interesting
but the design of the study was quite weak.
Reviewer's report
Title:Colon Capsule Endoscopy compared to Conventional Colonoscopy under
routine screening conditions
Version: 2Date:28 January 2010
Reviewer: Andre Van Gossum
Reviewer's report:
The authors report the results of a study that compared colon capsule and optical
colonoscopy in a CRC screening population. They describe a low sensitivity for
colon capsule but a high negative predictive value. They also report a low rate of
complete excretion (64%) and a low percentage of good colon prep.
General remarks
- The number of patients included in this trial designed for a screening procedure
is extremely low.
- As it is mentioned by the authors, the excretion rate and the colon cleanliness
were low. This is probably due to the modification of the colon prep. That shows
the importance of the timing of the procedure.
- Why the authors did use a 3 point scale and not the 4 point as it has been
described ?
- Results : the authors report several findings that were detected on colon
capsule and not on colonoscopy. That could be also false negative of
colonoscopy. It is a pity that a second look colonoscopy was not designed at
least for patients with the so-called significant polyps. The results are interesting
but the design of the study was quite weak.
Please review this paper.
user
Reviewer's report
Title:Colon Capsule Endoscopy compared to Conventional Colonoscopy under
routine screening conditions
Version: 2Date:28 January 2010
Reviewer: Andre Van Gossum
Reviewer's report:
The authors report the results of a study that compared colon capsule and optical
colonoscopy in a CRC screening population. They describe a low sensitivity for
colon capsule but a high negative predictive value. They also report a low rate of
complete excretion (64%) and a low percentage of good colon prep.
General remarks
- The number of patients included in this trial designed for a screening procedure
is extremely low.
- As it is mentioned by the authors, the excretion rate and the colon cleanliness
were low. This is probably due to the modification of the colon prep. That shows
the importance of the timing of the procedure.
- Why the authors did use a 3 point scale and not the 4 point as it has been
described ?
- Results : the authors report several findings that were detected on colon
capsule and not on colonoscopy. That could be also false negative of
colonoscopy. It is a pity that a second look colonoscopy was not designed at
least for patients with the so-called significant polyps. The results are interesting
but the design of the study was quite weak.
assistant