Reviewer's report
Title:Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in
experimental liver disease
Version: 1Date:29 September 2008
Reviewer: Mehmet Horoz
Reviewer's report:
The authors investigated the chronological sequence and quantitative
relationships between PON1 expression and activity, free radical production,
MCP-1 expression, and fibrosis in an experimental model. They sugegested a
hepato-protective role of PON1 against inflammation, fibrosis and liver disease
mediated by MCP-1.
Although the hepato-protective role of PON1 have been suggested in previous
report, the association of PON1 with MCP-1 is novel. the study is well designed
and the findings is well presented. In my opinion, reviewed paper doesn't need
major changes
There are only two minor points that should be addressed by the authors during
revision.
1-More detailed description of the statistical analysis.
2-There are a few grammatical errors that should be fixed.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in
experimental liver disease
Version: 1Date:29 September 2008
Reviewer: Mehmet Horoz
Reviewer's report:
The authors investigated the chronological sequence and quantitative
relationships between PON1 expression and activity, free radical production,
MCP-1 expression, and fibrosis in an experimental model. They sugegested a
hepato-protective role of PON1 against inflammation, fibrosis and liver disease
mediated by MCP-1.
Although the hepato-protective role of PON1 have been suggested in previous
report, the association of PON1 with MCP-1 is novel. the study is well designed
and the findings is well presented. In my opinion, reviewed paper doesn't need
major changes
There are only two minor points that should be addressed by the authors during
revision.
1-More detailed description of the statistical analysis.
2-There are a few grammatical errors that should be fixed.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Paraoxonase-1 is related to inflammation, fibrosis and PPAR delta in
experimental liver disease
Version: 1Date:29 September 2008
Reviewer: Mehmet Horoz
Reviewer's report:
The authors investigated the chronological sequence and quantitative
relationships between PON1 expression and activity, free radical production,
MCP-1 expression, and fibrosis in an experimental model. They sugegested a
hepato-protective role of PON1 against inflammation, fibrosis and liver disease
mediated by MCP-1.
Although the hepato-protective role of PON1 have been suggested in previous
report, the association of PON1 with MCP-1 is novel. the study is well designed
and the findings is well presented. In my opinion, reviewed paper doesn't need
major changes
There are only two minor points that should be addressed by the authors during
revision.
1-More detailed description of the statistical analysis.
2-There are a few grammatical errors that should be fixed.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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