Title: Exclusive Enteral Nutrition Remodels the Intestinal Flora in Patients with Active Crohn's
Disease
Version: 2 Date: 17 Mar 2022
Reviewer:  Gilles R.g. Monif
Reviewer's report:
The scientific method requires that you gather all the information relevant to what you
are proposing to do/ The authors have little idea of what Crohn's disease is. the paper
dies in the abstract. two of the first three lines are wrong. CD does not involve the entire
gastrointestinal tract, Its pathogenesis is clearly delineated The third sentence is meaningless
because now knowing the pathogenesis of Crohn's disease, we identify why exclusive   enteric
nutrition can fail as well as why it sometimes succeeds. I suggest Med Hypothesis2015,
85{878-881;Gastrointest. Disord. 2021 3:138-141 and Adv. Res. Gastroenterol. Hepatol. 10
2018 DOI;10:199080/ARGH.2018.10.555798.
Once re-orientated, define in great detail the composition of their enteric formula and the re-
organize their data around the study lines suggested by Ceylan Tanes et al..  AS lot of hard
work went into the production of the data, Measurement without hypothesis is not science. the
investigators should be encouraged to rewrite their paper/
Title: Exclusive Enteral Nutrition Remodels the Intestinal Flora in Patients with Active Crohn's
Disease
Version: 2 Date: 17 Mar 2022
Reviewer:  Gilles R.g. Monif
Reviewer's report:
The scientific method requires that you gather all the information relevant to what you
are proposing to do/ The authors have little idea of what Crohn's disease is. the paper
dies in the abstract. two of the first three lines are wrong. CD does not involve the entire
gastrointestinal tract, Its pathogenesis is clearly delineated The third sentence is meaningless
because now knowing the pathogenesis of Crohn's disease, we identify why exclusive   enteric
nutrition can fail as well as why it sometimes succeeds. I suggest Med Hypothesis2015,
85{878-881;Gastrointest. Disord. 2021 3:138-141 and Adv. Res. Gastroenterol. Hepatol. 10
2018 DOI;10:199080/ARGH.2018.10.555798.
Once re-orientated, define in great detail the composition of their enteric formula and the re-
organize their data around the study lines suggested by Ceylan Tanes et al..  AS lot of hard
work went into the production of the data, Measurement without hypothesis is not science. the
investigators should be encouraged to rewrite their paper/
Please review this paper.
user
Title: Exclusive Enteral Nutrition Remodels the Intestinal Flora in Patients with Active Crohn's
Disease
Version: 2 Date: 17 Mar 2022
Reviewer:  Gilles R.g. Monif
Reviewer's report:
The scientific method requires that you gather all the information relevant to what you
are proposing to do/ The authors have little idea of what Crohn's disease is. the paper
dies in the abstract. two of the first three lines are wrong. CD does not involve the entire
gastrointestinal tract, Its pathogenesis is clearly delineated The third sentence is meaningless
because now knowing the pathogenesis of Crohn's disease, we identify why exclusive   enteric
nutrition can fail as well as why it sometimes succeeds. I suggest Med Hypothesis2015,
85{878-881;Gastrointest. Disord. 2021 3:138-141 and Adv. Res. Gastroenterol. Hepatol. 10
2018 DOI;10:199080/ARGH.2018.10.555798.
Once re-orientated, define in great detail the composition of their enteric formula and the re-
organize their data around the study lines suggested by Ceylan Tanes et al..  AS lot of hard
work went into the production of the data, Measurement without hypothesis is not science. the
investigators should be encouraged to rewrite their paper/
assistant