Reviewer's report
Title:Paracetamol in therapeutic dosages and acute liver injury: causality
assessment in a prospective case series.
Version: 1Date:4 January 2011
Reviewer: Philip Newsome
Reviewer's report:
The authors report a series of cases in which ALI results from likely therapeutic
paracetamol ingestion. It is not clear however what this adds to the literature that
already exists relating to paracetamol induced toxicity. In that respect the
message of the manuscript is not adding to what is already known. The authors
need to be clear what advance they are proposing in their manuscript.
The manner in which the cases are decided to be paracetamol induced is not
entirely clear.
What was the outcome of these patients, and to what extent was the dose
adjusted for weight?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Paracetamol in therapeutic dosages and acute liver injury: causality
assessment in a prospective case series.
Version: 1Date:4 January 2011
Reviewer: Philip Newsome
Reviewer's report:
The authors report a series of cases in which ALI results from likely therapeutic
paracetamol ingestion. It is not clear however what this adds to the literature that
already exists relating to paracetamol induced toxicity. In that respect the
message of the manuscript is not adding to what is already known. The authors
need to be clear what advance they are proposing in their manuscript.
The manner in which the cases are decided to be paracetamol induced is not
entirely clear.
What was the outcome of these patients, and to what extent was the dose
adjusted for weight?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Paracetamol in therapeutic dosages and acute liver injury: causality
assessment in a prospective case series.
Version: 1Date:4 January 2011
Reviewer: Philip Newsome
Reviewer's report:
The authors report a series of cases in which ALI results from likely therapeutic
paracetamol ingestion. It is not clear however what this adds to the literature that
already exists relating to paracetamol induced toxicity. In that respect the
message of the manuscript is not adding to what is already known. The authors
need to be clear what advance they are proposing in their manuscript.
The manner in which the cases are decided to be paracetamol induced is not
entirely clear.
What was the outcome of these patients, and to what extent was the dose
adjusted for weight?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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