Reviewer's report
Title:Weak Up-regulation of Serum Response Factor in Gastric Ulcers in
Patients with Co-morbidities is Associated with Increased Risk of Recurrent
Bleeding
Version: 1Date:21 October 2010
Reviewer: Jianyuan Chai
Reviewer's report:
The study compared SRF expression in human gastric ulcerated tissues vs.
normal by immunohistochemistry and found SRF up-regulation in ulcers
regardless of what caused ulcers. The study also demonstrated that recurrent
ulcer bleeding rate is increased comorbidities and low expression of SRF and
both factors are independent but synergistic. Up-regulation of SRF in ulcers is
known in animal model, while this study examined human biopses, which is more
clinical relevant.
Minors:
1. In the last setence of the discussion, authors hope in the future study SRF can
be measured in the serum instead of tissue staining. Unfortunately, that is
impossible. SRF is a transcription factor. It cannot be measured by serum
check-up.
2. In multiple places of the text, authors say 'SRF expression on gastric ulcer
tissues', it should be 'in gastric tissues'.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Reviewer's report
Title:Weak Up-regulation of Serum Response Factor in Gastric Ulcers in
Patients with Co-morbidities is Associated with Increased Risk of Recurrent
Bleeding
Version: 1Date:21 October 2010
Reviewer: Jianyuan Chai
Reviewer's report:
The study compared SRF expression in human gastric ulcerated tissues vs.
normal by immunohistochemistry and found SRF up-regulation in ulcers
regardless of what caused ulcers. The study also demonstrated that recurrent
ulcer bleeding rate is increased comorbidities and low expression of SRF and
both factors are independent but synergistic. Up-regulation of SRF in ulcers is
known in animal model, while this study examined human biopses, which is more
clinical relevant.
Minors:
1. In the last setence of the discussion, authors hope in the future study SRF can
be measured in the serum instead of tissue staining. Unfortunately, that is
impossible. SRF is a transcription factor. It cannot be measured by serum
check-up.
2. In multiple places of the text, authors say 'SRF expression on gastric ulcer
tissues', it should be 'in gastric tissues'.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Please review this paper.
user
Reviewer's report
Title:Weak Up-regulation of Serum Response Factor in Gastric Ulcers in
Patients with Co-morbidities is Associated with Increased Risk of Recurrent
Bleeding
Version: 1Date:21 October 2010
Reviewer: Jianyuan Chai
Reviewer's report:
The study compared SRF expression in human gastric ulcerated tissues vs.
normal by immunohistochemistry and found SRF up-regulation in ulcers
regardless of what caused ulcers. The study also demonstrated that recurrent
ulcer bleeding rate is increased comorbidities and low expression of SRF and
both factors are independent but synergistic. Up-regulation of SRF in ulcers is
known in animal model, while this study examined human biopses, which is more
clinical relevant.
Minors:
1. In the last setence of the discussion, authors hope in the future study SRF can
be measured in the serum instead of tissue staining. Unfortunately, that is
impossible. SRF is a transcription factor. It cannot be measured by serum
check-up.
2. In multiple places of the text, authors say 'SRF expression on gastric ulcer
tissues', it should be 'in gastric tissues'.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
assistant