Title: Long-term effectiveness and safety of ustekinumab in bio-naïve and bio-experienced anti-
tumor necrosis factor patients with Crohn’s disease: a real-world multicenter Brazilian study
Version: 2 Date: 17 Jan 2022
Reviewer:  Santiago García López
Reviewer's report:
Interesting article, even being the first data in this geographical area. Large number of highly
refractory patients were included, reflecting the population treated in  clinical practice in many
countries. It is well written and the analysis correctly carried out, as well as the final conclusions.
I suggest reviewing the wording of the results within the abstract, may be confusing in my
opinion, although they are later well described in the text of the article.
Title: Long-term effectiveness and safety of ustekinumab in bio-naïve and bio-experienced anti-
tumor necrosis factor patients with Crohn’s disease: a real-world multicenter Brazilian study
Version: 2 Date: 17 Jan 2022
Reviewer:  Santiago García López
Reviewer's report:
Interesting article, even being the first data in this geographical area. Large number of highly
refractory patients were included, reflecting the population treated in  clinical practice in many
countries. It is well written and the analysis correctly carried out, as well as the final conclusions.
I suggest reviewing the wording of the results within the abstract, may be confusing in my
opinion, although they are later well described in the text of the article.
Please review this paper.
user
Title: Long-term effectiveness and safety of ustekinumab in bio-naïve and bio-experienced anti-
tumor necrosis factor patients with Crohn’s disease: a real-world multicenter Brazilian study
Version: 2 Date: 17 Jan 2022
Reviewer:  Santiago García López
Reviewer's report:
Interesting article, even being the first data in this geographical area. Large number of highly
refractory patients were included, reflecting the population treated in  clinical practice in many
countries. It is well written and the analysis correctly carried out, as well as the final conclusions.
I suggest reviewing the wording of the results within the abstract, may be confusing in my
opinion, although they are later well described in the text of the article.
assistant