Reviewer's report
Title:Hepatic stellate cells: central modulators of hepatic carcinogenesis
Version:2Date:6 April 2015
Reviewer: Shannon Glaser
Reviewer's report:
Minor Essential Revisions:
1. The review “Hepatic stellate cells: central modulators of hepatic
carcinogenesis” by Thompson, et. al. does cover an area of importance in the
field covered by the journal.
2. The review presents a comprehensive, authoritative review of existing work on
the role that HSCs play in the progression of hepatocellular carcinoma (HCC),
specifically the key components produced by HSCs that modulate HCC tumor
formation and how these pathways may be targeted as new therapeutic options
for the treatment of HCC.
Other comments:
In Lines 54-57 the authors mention that chronic Hepatitis B infection is one of the
major risk factors for HCC. Then, in the next sentence in Lines 57 and 58 they
mention that “In most countries, the mortality rate approximates the incidence,
which is increasing”. It is not clear whether the authors are referring to the
mortality rate of HCC or the mortality rate of Hepatitis B in this sentence, so that
should be clarified.
In line 415 the references in the brackets should be combined [119-121] instead
of [119] [120] [121].
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Hepatic stellate cells: central modulators of hepatic carcinogenesis
Version:2Date:6 April 2015
Reviewer: Shannon Glaser
Reviewer's report:
Minor Essential Revisions:
1. The review “Hepatic stellate cells: central modulators of hepatic
carcinogenesis” by Thompson, et. al. does cover an area of importance in the
field covered by the journal.
2. The review presents a comprehensive, authoritative review of existing work on
the role that HSCs play in the progression of hepatocellular carcinoma (HCC),
specifically the key components produced by HSCs that modulate HCC tumor
formation and how these pathways may be targeted as new therapeutic options
for the treatment of HCC.
Other comments:
In Lines 54-57 the authors mention that chronic Hepatitis B infection is one of the
major risk factors for HCC. Then, in the next sentence in Lines 57 and 58 they
mention that “In most countries, the mortality rate approximates the incidence,
which is increasing”. It is not clear whether the authors are referring to the
mortality rate of HCC or the mortality rate of Hepatitis B in this sentence, so that
should be clarified.
In line 415 the references in the brackets should be combined [119-121] instead
of [119] [120] [121].
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Hepatic stellate cells: central modulators of hepatic carcinogenesis
Version:2Date:6 April 2015
Reviewer: Shannon Glaser
Reviewer's report:
Minor Essential Revisions:
1. The review “Hepatic stellate cells: central modulators of hepatic
carcinogenesis” by Thompson, et. al. does cover an area of importance in the
field covered by the journal.
2. The review presents a comprehensive, authoritative review of existing work on
the role that HSCs play in the progression of hepatocellular carcinoma (HCC),
specifically the key components produced by HSCs that modulate HCC tumor
formation and how these pathways may be targeted as new therapeutic options
for the treatment of HCC.
Other comments:
In Lines 54-57 the authors mention that chronic Hepatitis B infection is one of the
major risk factors for HCC. Then, in the next sentence in Lines 57 and 58 they
mention that “In most countries, the mortality rate approximates the incidence,
which is increasing”. It is not clear whether the authors are referring to the
mortality rate of HCC or the mortality rate of Hepatitis B in this sentence, so that
should be clarified.
In line 415 the references in the brackets should be combined [119-121] instead
of [119] [120] [121].
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant