Reviewer's report
Title:Effect of apple cider vinegar on delayed gastric emptying in patients with
type 1 diabetes mellitus: a pilot study
Version: 4Date:20 November 2007
Reviewer: Karen Jones
Reviewer's report:
General
The authors have revised the manuscript. Please find additional issues below
that require attention:
-------------------------------------------------------------------------------
Major Compulsory Revisions (that the author must respond to before a decision
on publication can be reached)
-------------------------------------------------------------------------------
Minor Essential Revisions (such as missing labels on figures, or the wrong use of
a term, which the author can be trusted to correct)
1. Abstract; ln30: insert ‘investigator’ blinded crossover trial…; Discussion; p 11,
ln 234: add the statement ‘it was not randomised and the subjects were not
blinded.’
2. Methods; p 5: The authors state that a questionnaire was used to assess
symptoms. If this is the case, please provide the reference for this questionnaire.
3. Methods; p 5, line 100: Modifiy the sentence to include ‘a history of’ ie “Seven
of the subjects had a history of peripheral neuropathy…”
4. Methods; p7: Please clarify if the same ultrasound machine was used for the
paired studies. If not, please acknowledge this limitation in the manuscript ie
variations in measurement between the different machines may be present.
5. Background; p 3, ln 60-61: Please modify the sentence to read: ‘There is a
significant, albeit weak, relationship between gastric emptying of solids and the
presence of upper gastrointestinal symptoms; increased retention in the distal but
not proximal stomach is associated with increased gastrointestinal symptoms.’
The reference (13) is incorrect – should read: Jones KL, Horowitz M, Wishart JM,
Maddox AF, Harding P, Chatterton BE. Relationships between gastric emptying,
intragastric meal distribution and blood glucose concentrations in diabetes
mellitus. J Nucl Med 1995;36:2220-2228.
6. The authors state that they corrected the figure legend for Figure 1 – this has
not been done. Please modify to read: ‘clinically’’ diagnosed gastroparesis.
7. Methods, p8, ln174-175: modify the SPSS company details to read: ‘were
performed in SPSS for Windows (SPSS (Version 14.0, 2005); Chicago, IL, USA)’
-------------------------------------------------------------------------------
Discretionary Revisions (which the author can choose to ignore)
What next?: Accept after minor essential revisions
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Effect of apple cider vinegar on delayed gastric emptying in patients with
type 1 diabetes mellitus: a pilot study
Version: 4Date:20 November 2007
Reviewer: Karen Jones
Reviewer's report:
General
The authors have revised the manuscript. Please find additional issues below
that require attention:
-------------------------------------------------------------------------------
Major Compulsory Revisions (that the author must respond to before a decision
on publication can be reached)
-------------------------------------------------------------------------------
Minor Essential Revisions (such as missing labels on figures, or the wrong use of
a term, which the author can be trusted to correct)
1. Abstract; ln30: insert ‘investigator’ blinded crossover trial…; Discussion; p 11,
ln 234: add the statement ‘it was not randomised and the subjects were not
blinded.’
2. Methods; p 5: The authors state that a questionnaire was used to assess
symptoms. If this is the case, please provide the reference for this questionnaire.
3. Methods; p 5, line 100: Modifiy the sentence to include ‘a history of’ ie “Seven
of the subjects had a history of peripheral neuropathy…”
4. Methods; p7: Please clarify if the same ultrasound machine was used for the
paired studies. If not, please acknowledge this limitation in the manuscript ie
variations in measurement between the different machines may be present.
5. Background; p 3, ln 60-61: Please modify the sentence to read: ‘There is a
significant, albeit weak, relationship between gastric emptying of solids and the
presence of upper gastrointestinal symptoms; increased retention in the distal but
not proximal stomach is associated with increased gastrointestinal symptoms.’
The reference (13) is incorrect – should read: Jones KL, Horowitz M, Wishart JM,
Maddox AF, Harding P, Chatterton BE. Relationships between gastric emptying,
intragastric meal distribution and blood glucose concentrations in diabetes
mellitus. J Nucl Med 1995;36:2220-2228.
6. The authors state that they corrected the figure legend for Figure 1 – this has
not been done. Please modify to read: ‘clinically’’ diagnosed gastroparesis.
7. Methods, p8, ln174-175: modify the SPSS company details to read: ‘were
performed in SPSS for Windows (SPSS (Version 14.0, 2005); Chicago, IL, USA)’
-------------------------------------------------------------------------------
Discretionary Revisions (which the author can choose to ignore)
What next?: Accept after minor essential revisions
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Effect of apple cider vinegar on delayed gastric emptying in patients with
type 1 diabetes mellitus: a pilot study
Version: 4Date:20 November 2007
Reviewer: Karen Jones
Reviewer's report:
General
The authors have revised the manuscript. Please find additional issues below
that require attention:
-------------------------------------------------------------------------------
Major Compulsory Revisions (that the author must respond to before a decision
on publication can be reached)
-------------------------------------------------------------------------------
Minor Essential Revisions (such as missing labels on figures, or the wrong use of
a term, which the author can be trusted to correct)
1. Abstract; ln30: insert ‘investigator’ blinded crossover trial…; Discussion; p 11,
ln 234: add the statement ‘it was not randomised and the subjects were not
blinded.’
2. Methods; p 5: The authors state that a questionnaire was used to assess
symptoms. If this is the case, please provide the reference for this questionnaire.
3. Methods; p 5, line 100: Modifiy the sentence to include ‘a history of’ ie “Seven
of the subjects had a history of peripheral neuropathy…”
4. Methods; p7: Please clarify if the same ultrasound machine was used for the
paired studies. If not, please acknowledge this limitation in the manuscript ie
variations in measurement between the different machines may be present.
5. Background; p 3, ln 60-61: Please modify the sentence to read: ‘There is a
significant, albeit weak, relationship between gastric emptying of solids and the
presence of upper gastrointestinal symptoms; increased retention in the distal but
not proximal stomach is associated with increased gastrointestinal symptoms.’
The reference (13) is incorrect – should read: Jones KL, Horowitz M, Wishart JM,
Maddox AF, Harding P, Chatterton BE. Relationships between gastric emptying,
intragastric meal distribution and blood glucose concentrations in diabetes
mellitus. J Nucl Med 1995;36:2220-2228.
6. The authors state that they corrected the figure legend for Figure 1 – this has
not been done. Please modify to read: ‘clinically’’ diagnosed gastroparesis.
7. Methods, p8, ln174-175: modify the SPSS company details to read: ‘were
performed in SPSS for Windows (SPSS (Version 14.0, 2005); Chicago, IL, USA)’
-------------------------------------------------------------------------------
Discretionary Revisions (which the author can choose to ignore)
What next?: Accept after minor essential revisions
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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