Title: High Correlation of Hepatic Shear Wave Velocity with Esophageal Varices Complication
Rate in Patients with Chronic Liver Diseases
Version: 3 Date: 01 May 2023
Reviewer's report:
The authors revised the manuscript according to my comments. But I still have a major concern.
#1. Abstract. “The area under the curve (AUC) of Vs was 0.902; it was a better indicator for
cirrhosis (F4) than blood markers. The AUC for predicting EVs by Vs was 0.901, which was
higher than those of histological fibrosis stage, blood markers, and splenic volume.”
These sentences are wrong, since they described the results of statistical analysis in Results as
below.
Comparison of ROC curves showed that AUROC for predicting cirrhosis of Vs value was not
significantly different from AUROC for FIB-4 index, platelet count, hyaluronic acid and type
IV collagen 7S, while it was significantly different from AUROC for M2BPGi (P<0.01).
Comparison of ROC curves showed that AUROC for predicting EVs of Vs value was not
significantly different from AUROC for fibrosis stage 3-4 (liver biopsy) and type IV collagen
7S, while it was significantly different from AUROC for FIB-4 index (P<0.05), platelet count
(P<0.05), M2BPGi (P<0.01), hyaluronic acid (P<0.05) and splenic volume (P<0.05).
Title: High Correlation of Hepatic Shear Wave Velocity with Esophageal Varices Complication
Rate in Patients with Chronic Liver Diseases
Version: 3 Date: 01 May 2023
Reviewer's report:
The authors revised the manuscript according to my comments. But I still have a major concern.
#1. Abstract. “The area under the curve (AUC) of Vs was 0.902; it was a better indicator for
cirrhosis (F4) than blood markers. The AUC for predicting EVs by Vs was 0.901, which was
higher than those of histological fibrosis stage, blood markers, and splenic volume.”
These sentences are wrong, since they described the results of statistical analysis in Results as
below.
Comparison of ROC curves showed that AUROC for predicting cirrhosis of Vs value was not
significantly different from AUROC for FIB-4 index, platelet count, hyaluronic acid and type
IV collagen 7S, while it was significantly different from AUROC for M2BPGi (P<0.01).
Comparison of ROC curves showed that AUROC for predicting EVs of Vs value was not
significantly different from AUROC for fibrosis stage 3-4 (liver biopsy) and type IV collagen
7S, while it was significantly different from AUROC for FIB-4 index (P<0.05), platelet count
(P<0.05), M2BPGi (P<0.01), hyaluronic acid (P<0.05) and splenic volume (P<0.05).
Please review this paper.
user
Title: High Correlation of Hepatic Shear Wave Velocity with Esophageal Varices Complication
Rate in Patients with Chronic Liver Diseases
Version: 3 Date: 01 May 2023
Reviewer's report:
The authors revised the manuscript according to my comments. But I still have a major concern.
#1. Abstract. “The area under the curve (AUC) of Vs was 0.902; it was a better indicator for
cirrhosis (F4) than blood markers. The AUC for predicting EVs by Vs was 0.901, which was
higher than those of histological fibrosis stage, blood markers, and splenic volume.”
These sentences are wrong, since they described the results of statistical analysis in Results as
below.
Comparison of ROC curves showed that AUROC for predicting cirrhosis of Vs value was not
significantly different from AUROC for FIB-4 index, platelet count, hyaluronic acid and type
IV collagen 7S, while it was significantly different from AUROC for M2BPGi (P<0.01).
Comparison of ROC curves showed that AUROC for predicting EVs of Vs value was not
significantly different from AUROC for fibrosis stage 3-4 (liver biopsy) and type IV collagen
7S, while it was significantly different from AUROC for FIB-4 index (P<0.05), platelet count
(P<0.05), M2BPGi (P<0.01), hyaluronic acid (P<0.05) and splenic volume (P<0.05).
assistant