Title: Impact of Occupation on Survival of Esophageal Squamous Cell Carcinoma Patients
Following Esophagectomy : A Long-term Survival Analysis
Version: 2 Date: 10 Mar 2025
Reviewer's report:
This study examines the impact of occupational background on the long-term survival of ESCC
patients following esophagectomy. However, several issues need to be addressed:
Formatting Issues: The manuscript does not adhere to the required formatting guidelines.
Line spacing is inconsistent, numbers should be formatted with commas every three digits,
and spacing errors (e.g., on page 6) need correction. Additionally, tables extend beyond page
boundaries.
Missing Key Clinical Variables: The study does not account for crucial prognostic factors such
as smoking and alcohol consumption, which significantly influence cancer outcomes. Their
omission weakens the validity of the analysis.
Multivariate Analysis Details: The manuscript does not specify which variables were adjusted
for in the multivariate analysis. Clearly stating these variables is essential for assessing the
robustness of the findings.
Selection of Occupational Categories: The study includes only four occupational groups—
Farmer, Civil Servant, Teacher, and Factory Worker. However, the rationale for selecting these
specific occupations is unclear. The lack of justification raises concerns about the study's novelty
and generalizability.
Logical Inconsistency in Occupational Stress and Survival: The assumption that civil servants
experience more stress than farmers, leading to differences in cancer survival, appears to be a
logical overreach. The reasoning needs stronger evidence and theoretical support.
Given these significant concerns, I recommend rejecting the manuscript in its current form.
Title: Impact of Occupation on Survival of Esophageal Squamous Cell Carcinoma Patients
Following Esophagectomy : A Long-term Survival Analysis
Version: 2 Date: 10 Mar 2025
Reviewer's report:
This study examines the impact of occupational background on the long-term survival of ESCC
patients following esophagectomy. However, several issues need to be addressed:
Formatting Issues: The manuscript does not adhere to the required formatting guidelines.
Line spacing is inconsistent, numbers should be formatted with commas every three digits,
and spacing errors (e.g., on page 6) need correction. Additionally, tables extend beyond page
boundaries.
Missing Key Clinical Variables: The study does not account for crucial prognostic factors such
as smoking and alcohol consumption, which significantly influence cancer outcomes. Their
omission weakens the validity of the analysis.
Multivariate Analysis Details: The manuscript does not specify which variables were adjusted
for in the multivariate analysis. Clearly stating these variables is essential for assessing the
robustness of the findings.
Selection of Occupational Categories: The study includes only four occupational groups—
Farmer, Civil Servant, Teacher, and Factory Worker. However, the rationale for selecting these
specific occupations is unclear. The lack of justification raises concerns about the study's novelty
and generalizability.
Logical Inconsistency in Occupational Stress and Survival: The assumption that civil servants
experience more stress than farmers, leading to differences in cancer survival, appears to be a
logical overreach. The reasoning needs stronger evidence and theoretical support.
Given these significant concerns, I recommend rejecting the manuscript in its current form.
Please review this paper.
user
Title: Impact of Occupation on Survival of Esophageal Squamous Cell Carcinoma Patients
Following Esophagectomy : A Long-term Survival Analysis
Version: 2 Date: 10 Mar 2025
Reviewer's report:
This study examines the impact of occupational background on the long-term survival of ESCC
patients following esophagectomy. However, several issues need to be addressed:
Formatting Issues: The manuscript does not adhere to the required formatting guidelines.
Line spacing is inconsistent, numbers should be formatted with commas every three digits,
and spacing errors (e.g., on page 6) need correction. Additionally, tables extend beyond page
boundaries.
Missing Key Clinical Variables: The study does not account for crucial prognostic factors such
as smoking and alcohol consumption, which significantly influence cancer outcomes. Their
omission weakens the validity of the analysis.
Multivariate Analysis Details: The manuscript does not specify which variables were adjusted
for in the multivariate analysis. Clearly stating these variables is essential for assessing the
robustness of the findings.
Selection of Occupational Categories: The study includes only four occupational groups—
Farmer, Civil Servant, Teacher, and Factory Worker. However, the rationale for selecting these
specific occupations is unclear. The lack of justification raises concerns about the study's novelty
and generalizability.
Logical Inconsistency in Occupational Stress and Survival: The assumption that civil servants
experience more stress than farmers, leading to differences in cancer survival, appears to be a
logical overreach. The reasoning needs stronger evidence and theoretical support.
Given these significant concerns, I recommend rejecting the manuscript in its current form.
assistant