Reviewer's report
Title:Giant pedunculated hepatocellular carcinoma with hemangioma mimicking
intestinal obstruction: A rare case
Version: 1Date:29 June 2011
Reviewer: Katsutoshi Sugimoto
Reviewer's report:
Comments to the Authors:
GENERAL COMMENT
This case report is about a pedunculated hepatocellular carcinoma, which is
relatively rare type of HCC. Previously, we experienced a case of pedunculated
hepatocellular carcinoma (p-HCC) (unpublished case). Base of the experience,
we sate below.
Major Compulsory Revisions
1. Some case reports showed that, compared with conventional HCC, p-HCC is
arises from normal liver. Our experienced case was also normal liver. However,
in this case, this patient had a history idiopathic hemochromatosis. Thus you
should describe that a causal association between P-HCC and idiopathic
hemochromatosis in discussion section.
2. Many studies showed that findings on unenhanced T2-weighted MR image
play a key role in differentiation of hemangioma and other heptic tumors.
Considering T2-weighted MR image in this case, the tumor have a low potential
for hemangioma. You should consider the imaging findings further in discussion
section.
Discretionary Revisions
In this case, unfortunately, dynamic study was not performed due to a several
allergic reaction to radio-opaque medium. We think that contrast-enhanced
ultrasound may be useful in the diagnosis of HCC.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Giant pedunculated hepatocellular carcinoma with hemangioma mimicking
intestinal obstruction: A rare case
Version: 1Date:29 June 2011
Reviewer: Katsutoshi Sugimoto
Reviewer's report:
Comments to the Authors:
GENERAL COMMENT
This case report is about a pedunculated hepatocellular carcinoma, which is
relatively rare type of HCC. Previously, we experienced a case of pedunculated
hepatocellular carcinoma (p-HCC) (unpublished case). Base of the experience,
we sate below.
Major Compulsory Revisions
1. Some case reports showed that, compared with conventional HCC, p-HCC is
arises from normal liver. Our experienced case was also normal liver. However,
in this case, this patient had a history idiopathic hemochromatosis. Thus you
should describe that a causal association between P-HCC and idiopathic
hemochromatosis in discussion section.
2. Many studies showed that findings on unenhanced T2-weighted MR image
play a key role in differentiation of hemangioma and other heptic tumors.
Considering T2-weighted MR image in this case, the tumor have a low potential
for hemangioma. You should consider the imaging findings further in discussion
section.
Discretionary Revisions
In this case, unfortunately, dynamic study was not performed due to a several
allergic reaction to radio-opaque medium. We think that contrast-enhanced
ultrasound may be useful in the diagnosis of HCC.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Giant pedunculated hepatocellular carcinoma with hemangioma mimicking
intestinal obstruction: A rare case
Version: 1Date:29 June 2011
Reviewer: Katsutoshi Sugimoto
Reviewer's report:
Comments to the Authors:
GENERAL COMMENT
This case report is about a pedunculated hepatocellular carcinoma, which is
relatively rare type of HCC. Previously, we experienced a case of pedunculated
hepatocellular carcinoma (p-HCC) (unpublished case). Base of the experience,
we sate below.
Major Compulsory Revisions
1. Some case reports showed that, compared with conventional HCC, p-HCC is
arises from normal liver. Our experienced case was also normal liver. However,
in this case, this patient had a history idiopathic hemochromatosis. Thus you
should describe that a causal association between P-HCC and idiopathic
hemochromatosis in discussion section.
2. Many studies showed that findings on unenhanced T2-weighted MR image
play a key role in differentiation of hemangioma and other heptic tumors.
Considering T2-weighted MR image in this case, the tumor have a low potential
for hemangioma. You should consider the imaging findings further in discussion
section.
Discretionary Revisions
In this case, unfortunately, dynamic study was not performed due to a several
allergic reaction to radio-opaque medium. We think that contrast-enhanced
ultrasound may be useful in the diagnosis of HCC.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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