Title: Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally
advanced rectal adenocarcinoma
Version: 2 Date: 09 Apr 2024
Reviewer's report:
Good topic for meta analysis.
Please consider in limitations:
-response to neoadjuvant radiation and chemotherapy is association with tumor stage; the
original data for studies used in this meta analysis was not assessed for tumor stage
-definition of tumor response to neoadjuvant radiation and chemotherapy  is not specific for %
change in tumor volume
-radiation dose and details of specific chemotherapy agents was not assessed for tumor response
on mucinous tumors
-whether nodes contained mucin was not asseessed for response
Title: Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally
advanced rectal adenocarcinoma
Version: 2 Date: 09 Apr 2024
Reviewer's report:
Good topic for meta analysis.
Please consider in limitations:
-response to neoadjuvant radiation and chemotherapy is association with tumor stage; the
original data for studies used in this meta analysis was not assessed for tumor stage
-definition of tumor response to neoadjuvant radiation and chemotherapy  is not specific for %
change in tumor volume
-radiation dose and details of specific chemotherapy agents was not assessed for tumor response
on mucinous tumors
-whether nodes contained mucin was not asseessed for response
Please review this paper.
user
Title: Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally
advanced rectal adenocarcinoma
Version: 2 Date: 09 Apr 2024
Reviewer's report:
Good topic for meta analysis.
Please consider in limitations:
-response to neoadjuvant radiation and chemotherapy is association with tumor stage; the
original data for studies used in this meta analysis was not assessed for tumor stage
-definition of tumor response to neoadjuvant radiation and chemotherapy  is not specific for %
change in tumor volume
-radiation dose and details of specific chemotherapy agents was not assessed for tumor response
on mucinous tumors
-whether nodes contained mucin was not asseessed for response
assistant