Title: Patient-Reported Outcome Measures in Functional Dyspepsia: A Systematic Review and
COSMIN Analysis
Version: 3 Date: 27 Mar 2023
Reviewer:  Nicholas J. Talley
Reviewer's report:
Patient reported outcomes matter in symptomatic disorders including  functional dyspepsia, and
a number of PROs have been published although none have met with  FDA approval, an issue
the authors should further comment on.
The current  study was conducted according to the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses (PRISMA) with searching of four to find any relevant PROs.
The investigators assigned an overall rating based on COSMIN guidelines, and the Grading of
Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to
assess the level of evidence for psychometric properties of included PROMs. The paper is clear
and well written.
The current work is an extension of a reasonably recent meta-analysis as the authors cite. They
did identify more PROs and did a more comprehensive psychometric review than the 2018 study.
However the broad conclusions are otherwise similar.
Smeets F G M, Masclee A a M, Conchillo J M, et al. Systematic review: Disease-
specific instruments to assess gastrointestinal symptoms in functional dyspepsia[J].
Neurogastroenterology and Motility, 2018, 30(8).
Why was the focus on symptoms not quality of life? Surely both sets of domains should be
included?
Title: Patient-Reported Outcome Measures in Functional Dyspepsia: A Systematic Review and
COSMIN Analysis
Version: 3 Date: 27 Mar 2023
Reviewer:  Nicholas J. Talley
Reviewer's report:
Patient reported outcomes matter in symptomatic disorders including  functional dyspepsia, and
a number of PROs have been published although none have met with  FDA approval, an issue
the authors should further comment on.
The current  study was conducted according to the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses (PRISMA) with searching of four to find any relevant PROs.
The investigators assigned an overall rating based on COSMIN guidelines, and the Grading of
Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to
assess the level of evidence for psychometric properties of included PROMs. The paper is clear
and well written.
The current work is an extension of a reasonably recent meta-analysis as the authors cite. They
did identify more PROs and did a more comprehensive psychometric review than the 2018 study.
However the broad conclusions are otherwise similar.
Smeets F G M, Masclee A a M, Conchillo J M, et al. Systematic review: Disease-
specific instruments to assess gastrointestinal symptoms in functional dyspepsia[J].
Neurogastroenterology and Motility, 2018, 30(8).
Why was the focus on symptoms not quality of life? Surely both sets of domains should be
included?
Please review this paper.
user
Title: Patient-Reported Outcome Measures in Functional Dyspepsia: A Systematic Review and
COSMIN Analysis
Version: 3 Date: 27 Mar 2023
Reviewer:  Nicholas J. Talley
Reviewer's report:
Patient reported outcomes matter in symptomatic disorders including  functional dyspepsia, and
a number of PROs have been published although none have met with  FDA approval, an issue
the authors should further comment on.
The current  study was conducted according to the Preferred Reporting Items for Systematic
Reviews and Meta-Analyses (PRISMA) with searching of four to find any relevant PROs.
The investigators assigned an overall rating based on COSMIN guidelines, and the Grading of
Recommendations Assessment, Development, and Evaluation (GRADE) approach was used to
assess the level of evidence for psychometric properties of included PROMs. The paper is clear
and well written.
The current work is an extension of a reasonably recent meta-analysis as the authors cite. They
did identify more PROs and did a more comprehensive psychometric review than the 2018 study.
However the broad conclusions are otherwise similar.
Smeets F G M, Masclee A a M, Conchillo J M, et al. Systematic review: Disease-
specific instruments to assess gastrointestinal symptoms in functional dyspepsia[J].
Neurogastroenterology and Motility, 2018, 30(8).
Why was the focus on symptoms not quality of life? Surely both sets of domains should be
included?
assistant