Reviewer's report
Title:Efficacy and safety of bevacizumab in elderly patients with metastatic
colorectal cancer: results from the Czech population-based registry
Version:1Date:10 January 2014
Reviewer: Axel Grothey
Reviewer's report:
Major
None
Minor
I would have liked to see a break down of efficacy correlated with the actual
chemotherapy backbone that patients received. The very observation that elderly
patients received less combination chemotherapy as first-line, but still had
comparable PFS and OS is interesting. This should be put in context with the
AVEX data.
Minor
The English used needs some polishing (e.g. instead of patients aged 65-75, it
should read patients age 65-75; Table 1: instead of Hypertension in anamnesis, it
should read history of hypoertension).
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I do not have any competing interests in reviewing this manuscript
Reviewer's report
Title:Efficacy and safety of bevacizumab in elderly patients with metastatic
colorectal cancer: results from the Czech population-based registry
Version:1Date:10 January 2014
Reviewer: Axel Grothey
Reviewer's report:
Major
None
Minor
I would have liked to see a break down of efficacy correlated with the actual
chemotherapy backbone that patients received. The very observation that elderly
patients received less combination chemotherapy as first-line, but still had
comparable PFS and OS is interesting. This should be put in context with the
AVEX data.
Minor
The English used needs some polishing (e.g. instead of patients aged 65-75, it
should read patients age 65-75; Table 1: instead of Hypertension in anamnesis, it
should read history of hypoertension).
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I do not have any competing interests in reviewing this manuscript
Please review this paper.
user
Reviewer's report
Title:Efficacy and safety of bevacizumab in elderly patients with metastatic
colorectal cancer: results from the Czech population-based registry
Version:1Date:10 January 2014
Reviewer: Axel Grothey
Reviewer's report:
Major
None
Minor
I would have liked to see a break down of efficacy correlated with the actual
chemotherapy backbone that patients received. The very observation that elderly
patients received less combination chemotherapy as first-line, but still had
comparable PFS and OS is interesting. This should be put in context with the
AVEX data.
Minor
The English used needs some polishing (e.g. instead of patients aged 65-75, it
should read patients age 65-75; Table 1: instead of Hypertension in anamnesis, it
should read history of hypoertension).
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I do not have any competing interests in reviewing this manuscript
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