Reviewer's report
Title:A retrospective case-control study of hepatitis C virus infection and oral
lichen planus in Japan: association with mutations in the core and NS5A region
of hepatitis C virus
Version: 2Date:5 January 2012
Reviewer: Takafumi Saito
Reviewer's report:
The authors reported the risk factors for the development of oral lichen planus in
Japanese patients with HCV infection. The findings of this paper are important to
understand one of the major complications associated with HCV.
Major revisions:
1.The association of lichen planus with HCV mutations they examined has not
been detected. The title of paper may mislead the readers, and thus replace it
with an appropriate one.
2.The p values of many factors to assess a potential association with the
development of lichen planus are significant in univariate analysis shown in Table
1. Which factors were included in a multiple logistic regression model to identify
factors for the development of lichen planus associated with HCV ? How about
the the thyroid disease as a factor ?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:A retrospective case-control study of hepatitis C virus infection and oral
lichen planus in Japan: association with mutations in the core and NS5A region
of hepatitis C virus
Version: 2Date:5 January 2012
Reviewer: Takafumi Saito
Reviewer's report:
The authors reported the risk factors for the development of oral lichen planus in
Japanese patients with HCV infection. The findings of this paper are important to
understand one of the major complications associated with HCV.
Major revisions:
1.The association of lichen planus with HCV mutations they examined has not
been detected. The title of paper may mislead the readers, and thus replace it
with an appropriate one.
2.The p values of many factors to assess a potential association with the
development of lichen planus are significant in univariate analysis shown in Table
1. Which factors were included in a multiple logistic regression model to identify
factors for the development of lichen planus associated with HCV ? How about
the the thyroid disease as a factor ?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:A retrospective case-control study of hepatitis C virus infection and oral
lichen planus in Japan: association with mutations in the core and NS5A region
of hepatitis C virus
Version: 2Date:5 January 2012
Reviewer: Takafumi Saito
Reviewer's report:
The authors reported the risk factors for the development of oral lichen planus in
Japanese patients with HCV infection. The findings of this paper are important to
understand one of the major complications associated with HCV.
Major revisions:
1.The association of lichen planus with HCV mutations they examined has not
been detected. The title of paper may mislead the readers, and thus replace it
with an appropriate one.
2.The p values of many factors to assess a potential association with the
development of lichen planus are significant in univariate analysis shown in Table
1. Which factors were included in a multiple logistic regression model to identify
factors for the development of lichen planus associated with HCV ? How about
the the thyroid disease as a factor ?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant