Reviewer's report
Title:1 MAC Isoflurane Preconditioning Induce Protective Effects of Heme
oxygenase-1 on Hepatic Ischemia Reperfusion in Rats
Version: 1Date:29 April 2010
Reviewer: Leandra Ramalho
Reviewer's report:
Major Compulsory Revisions
The authors should reinforce in the introduction and objective sets the
unpublished purpose of the study. It was better defined in the abstract set.
The hepatic TNF-alpha may be more representative using a PCR-RT analysis.
The Heme oxygenase-1 pathway is related with oxidative stress, the authors
should investigate another markers of oxidative stress, as well as, nitrotyrosine,
MDA, etc.
Minor Essential Revisions
There are excessive arrows in the figure 3
The figure 7 presented H&E stain with a yellow background
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:1 MAC Isoflurane Preconditioning Induce Protective Effects of Heme
oxygenase-1 on Hepatic Ischemia Reperfusion in Rats
Version: 1Date:29 April 2010
Reviewer: Leandra Ramalho
Reviewer's report:
Major Compulsory Revisions
The authors should reinforce in the introduction and objective sets the
unpublished purpose of the study. It was better defined in the abstract set.
The hepatic TNF-alpha may be more representative using a PCR-RT analysis.
The Heme oxygenase-1 pathway is related with oxidative stress, the authors
should investigate another markers of oxidative stress, as well as, nitrotyrosine,
MDA, etc.
Minor Essential Revisions
There are excessive arrows in the figure 3
The figure 7 presented H&E stain with a yellow background
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:1 MAC Isoflurane Preconditioning Induce Protective Effects of Heme
oxygenase-1 on Hepatic Ischemia Reperfusion in Rats
Version: 1Date:29 April 2010
Reviewer: Leandra Ramalho
Reviewer's report:
Major Compulsory Revisions
The authors should reinforce in the introduction and objective sets the
unpublished purpose of the study. It was better defined in the abstract set.
The hepatic TNF-alpha may be more representative using a PCR-RT analysis.
The Heme oxygenase-1 pathway is related with oxidative stress, the authors
should investigate another markers of oxidative stress, as well as, nitrotyrosine,
MDA, etc.
Minor Essential Revisions
There are excessive arrows in the figure 3
The figure 7 presented H&E stain with a yellow background
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant