Reviewer's report
Title:Fast food diet with CCl4 micro-dose induced hepatic-fibrosis -A Novel
animal model
Version:3Date:23 March 2014
Reviewer: Dina Tiniakos
Reviewer's report:
Minor essential revisions
1. Methods, Pathology, staging of fibrosis: Please add “modified from” when
referring to the study of Kleiner et al, 2005 in the text and in additional file 1
because the staging method described is not exactly the same. In additional file
1, the title of the 2nd column should be changed to “Fibrosis” and “per sinusoidal”
(stage 1, degree of severity) should be spelled correctly. In additional file 2,
inflammation according to Kleiner et al (2005) is scored per x20 HPF not x40 as
wrongly stated. Please correct and mention in the text that sections were also
examined x20.
2. Results, paragraph 5: The exact topography of steatohepatitic lesions should
be included (perivenular, periportal/septal or both?).
3. Results: In Table 4 the title of the 1st column “Fibrosis scores” should be
changed to “Histological scores” since other features in addition to fibrosis are
evaluated.
4. References: Please delete sentence in bold at the end of reference 25.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Fast food diet with CCl4 micro-dose induced hepatic-fibrosis -A Novel
animal model
Version:3Date:23 March 2014
Reviewer: Dina Tiniakos
Reviewer's report:
Minor essential revisions
1. Methods, Pathology, staging of fibrosis: Please add “modified from” when
referring to the study of Kleiner et al, 2005 in the text and in additional file 1
because the staging method described is not exactly the same. In additional file
1, the title of the 2nd column should be changed to “Fibrosis” and “per sinusoidal”
(stage 1, degree of severity) should be spelled correctly. In additional file 2,
inflammation according to Kleiner et al (2005) is scored per x20 HPF not x40 as
wrongly stated. Please correct and mention in the text that sections were also
examined x20.
2. Results, paragraph 5: The exact topography of steatohepatitic lesions should
be included (perivenular, periportal/septal or both?).
3. Results: In Table 4 the title of the 1st column “Fibrosis scores” should be
changed to “Histological scores” since other features in addition to fibrosis are
evaluated.
4. References: Please delete sentence in bold at the end of reference 25.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Fast food diet with CCl4 micro-dose induced hepatic-fibrosis -A Novel
animal model
Version:3Date:23 March 2014
Reviewer: Dina Tiniakos
Reviewer's report:
Minor essential revisions
1. Methods, Pathology, staging of fibrosis: Please add “modified from” when
referring to the study of Kleiner et al, 2005 in the text and in additional file 1
because the staging method described is not exactly the same. In additional file
1, the title of the 2nd column should be changed to “Fibrosis” and “per sinusoidal”
(stage 1, degree of severity) should be spelled correctly. In additional file 2,
inflammation according to Kleiner et al (2005) is scored per x20 HPF not x40 as
wrongly stated. Please correct and mention in the text that sections were also
examined x20.
2. Results, paragraph 5: The exact topography of steatohepatitic lesions should
be included (perivenular, periportal/septal or both?).
3. Results: In Table 4 the title of the 1st column “Fibrosis scores” should be
changed to “Histological scores” since other features in addition to fibrosis are
evaluated.
4. References: Please delete sentence in bold at the end of reference 25.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
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