Reviewer's report
Title:Clinical Impact of a Gluten-Free Diet on Health-Related Quality of Life in
Fibromyalgia plus Irritable Bowel Syndrome Patients with Underlying Celiac
Disease
Version: 2Date:17 June 2013
Reviewer: Gabrio Bassotti
Reviewer's report:
Major Compulsory Revision
altthough this paper shows some interesting points, it also features a major flaw,
in that only Marsh3 CD patients were considered. Since there is presently ample
evidence that even lesser degrees of mucosal involvement (i.e., microscopic
enteritis) are associated with significant impairment of (micro)nutrients, the
authors should report all the various degrees of Marsh-Oberhuber classification
they found, with the associated biochemical abnormalities and the response to
GFD.
Minor Essential Revisions
how were the duodenal biopsy assessed, plòease give details, since this is
extremely important in the evaluation of CD patients
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Clinical Impact of a Gluten-Free Diet on Health-Related Quality of Life in
Fibromyalgia plus Irritable Bowel Syndrome Patients with Underlying Celiac
Disease
Version: 2Date:17 June 2013
Reviewer: Gabrio Bassotti
Reviewer's report:
Major Compulsory Revision
altthough this paper shows some interesting points, it also features a major flaw,
in that only Marsh3 CD patients were considered. Since there is presently ample
evidence that even lesser degrees of mucosal involvement (i.e., microscopic
enteritis) are associated with significant impairment of (micro)nutrients, the
authors should report all the various degrees of Marsh-Oberhuber classification
they found, with the associated biochemical abnormalities and the response to
GFD.
Minor Essential Revisions
how were the duodenal biopsy assessed, plòease give details, since this is
extremely important in the evaluation of CD patients
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Clinical Impact of a Gluten-Free Diet on Health-Related Quality of Life in
Fibromyalgia plus Irritable Bowel Syndrome Patients with Underlying Celiac
Disease
Version: 2Date:17 June 2013
Reviewer: Gabrio Bassotti
Reviewer's report:
Major Compulsory Revision
altthough this paper shows some interesting points, it also features a major flaw,
in that only Marsh3 CD patients were considered. Since there is presently ample
evidence that even lesser degrees of mucosal involvement (i.e., microscopic
enteritis) are associated with significant impairment of (micro)nutrients, the
authors should report all the various degrees of Marsh-Oberhuber classification
they found, with the associated biochemical abnormalities and the response to
GFD.
Minor Essential Revisions
how were the duodenal biopsy assessed, plòease give details, since this is
extremely important in the evaluation of CD patients
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant