Title: Trajectories of depressive symptoms and risk of chronic liver disease: Evidence from
CHARLS
Version: 1 Date: 19 Feb 2025
Reviewer's report:
The manuscript does not provide a theoretical framework to justify the selection of variables.
The rationale behind including specific variables is unclear. You are testing here and why.
The description of the subgroup analysis is overly vague. The manuscript mentions the use
of RERI, AP, and SI to evaluate additive interaction, but the results section only provides a
brief statement without clear explanation of the values or their implications. Additionally, the
concept of multiplicative interaction is mentioned without proper context or detailed results.
Please provide a more comprehensive explanation of how these measures were calculated and
their interpretations, and ensure that the corresponding data in the tables are clearly described.
For instance, the statement regarding the association between depressive symptom trajectories
and the risk of CLD in almost all subgroups (Table 3) and the absence of interactions
(Table 4) lacks sufficient detail. It is recommended to consult established  (DOI: 10.1186/
s13195-020-00691-6) to ensure that subgroup analyses are reported comprehensively, including
clear definitions, appropriate interaction tests, effect sizes, confidence intervals, and P-values
for interactions.
The manuscript does not clearly indicate whether the results presented are weighted or
unweighted. Please clarify the weighting method applied in the analysis and ensure that the
appropriate weights are used to account for the sampling design if necessary.
Add expert assessments of the results obtained.
Title: Trajectories of depressive symptoms and risk of chronic liver disease: Evidence from
CHARLS
Version: 1 Date: 19 Feb 2025
Reviewer's report:
The manuscript does not provide a theoretical framework to justify the selection of variables.
The rationale behind including specific variables is unclear. You are testing here and why.
The description of the subgroup analysis is overly vague. The manuscript mentions the use
of RERI, AP, and SI to evaluate additive interaction, but the results section only provides a
brief statement without clear explanation of the values or their implications. Additionally, the
concept of multiplicative interaction is mentioned without proper context or detailed results.
Please provide a more comprehensive explanation of how these measures were calculated and
their interpretations, and ensure that the corresponding data in the tables are clearly described.
For instance, the statement regarding the association between depressive symptom trajectories
and the risk of CLD in almost all subgroups (Table 3) and the absence of interactions
(Table 4) lacks sufficient detail. It is recommended to consult established  (DOI: 10.1186/
s13195-020-00691-6) to ensure that subgroup analyses are reported comprehensively, including
clear definitions, appropriate interaction tests, effect sizes, confidence intervals, and P-values
for interactions.
The manuscript does not clearly indicate whether the results presented are weighted or
unweighted. Please clarify the weighting method applied in the analysis and ensure that the
appropriate weights are used to account for the sampling design if necessary.
Add expert assessments of the results obtained.
Please review this paper.
user
Title: Trajectories of depressive symptoms and risk of chronic liver disease: Evidence from
CHARLS
Version: 1 Date: 19 Feb 2025
Reviewer's report:
The manuscript does not provide a theoretical framework to justify the selection of variables.
The rationale behind including specific variables is unclear. You are testing here and why.
The description of the subgroup analysis is overly vague. The manuscript mentions the use
of RERI, AP, and SI to evaluate additive interaction, but the results section only provides a
brief statement without clear explanation of the values or their implications. Additionally, the
concept of multiplicative interaction is mentioned without proper context or detailed results.
Please provide a more comprehensive explanation of how these measures were calculated and
their interpretations, and ensure that the corresponding data in the tables are clearly described.
For instance, the statement regarding the association between depressive symptom trajectories
and the risk of CLD in almost all subgroups (Table 3) and the absence of interactions
(Table 4) lacks sufficient detail. It is recommended to consult established  (DOI: 10.1186/
s13195-020-00691-6) to ensure that subgroup analyses are reported comprehensively, including
clear definitions, appropriate interaction tests, effect sizes, confidence intervals, and P-values
for interactions.
The manuscript does not clearly indicate whether the results presented are weighted or
unweighted. Please clarify the weighting method applied in the analysis and ensure that the
appropriate weights are used to account for the sampling design if necessary.
Add expert assessments of the results obtained.
assistant