Title: Effect of L-carnitine Supplementation on Muscle Cramps in Liver Cirrhosis: Results from
a Retrospective Cohort Study
Version: 1 Date: 01 Dec 2024
Reviewer's report:
In this manuscript entitled “Effect of L-carnitine Supplementation on Muscle Cramps in Liver
Cirrhosis: Results from a Retrospective Cohort Study”, the authors examined the association
between levocarnitine supplementation and muscle cramps in patients with cirrhosis. While this
is an interesting study, there are some concerns which should be clarified.
Major comments
1. Malnutrition is important in the pathogenesis of muscle cramps in patients with liver cirrhosis
(PMID: 35861232). The authors should make an introduction regarding this point.
2. In the result section, the authors should demonstrate the baseline characteristics of the included
patients such as Child-Pugh score, MELD score, other medications, and laboratory data.
3. The molecular mechanism of levocarnitine on muscle cramps needs to be explained in the
discussion session (PMID: 31864971).
4. Levocarnitine also improves mortality in patients with cirrhosis. The authors should add a
discussion in this point (PMID: 35511698).
Title: Effect of L-carnitine Supplementation on Muscle Cramps in Liver Cirrhosis: Results from
a Retrospective Cohort Study
Version: 1 Date: 01 Dec 2024
Reviewer's report:
In this manuscript entitled “Effect of L-carnitine Supplementation on Muscle Cramps in Liver
Cirrhosis: Results from a Retrospective Cohort Study”, the authors examined the association
between levocarnitine supplementation and muscle cramps in patients with cirrhosis. While this
is an interesting study, there are some concerns which should be clarified.
Major comments
1. Malnutrition is important in the pathogenesis of muscle cramps in patients with liver cirrhosis
(PMID: 35861232). The authors should make an introduction regarding this point.
2. In the result section, the authors should demonstrate the baseline characteristics of the included
patients such as Child-Pugh score, MELD score, other medications, and laboratory data.
3. The molecular mechanism of levocarnitine on muscle cramps needs to be explained in the
discussion session (PMID: 31864971).
4. Levocarnitine also improves mortality in patients with cirrhosis. The authors should add a
discussion in this point (PMID: 35511698).
Please review this paper.
user
Title: Effect of L-carnitine Supplementation on Muscle Cramps in Liver Cirrhosis: Results from
a Retrospective Cohort Study
Version: 1 Date: 01 Dec 2024
Reviewer's report:
In this manuscript entitled “Effect of L-carnitine Supplementation on Muscle Cramps in Liver
Cirrhosis: Results from a Retrospective Cohort Study”, the authors examined the association
between levocarnitine supplementation and muscle cramps in patients with cirrhosis. While this
is an interesting study, there are some concerns which should be clarified.
Major comments
1. Malnutrition is important in the pathogenesis of muscle cramps in patients with liver cirrhosis
(PMID: 35861232). The authors should make an introduction regarding this point.
2. In the result section, the authors should demonstrate the baseline characteristics of the included
patients such as Child-Pugh score, MELD score, other medications, and laboratory data.
3. The molecular mechanism of levocarnitine on muscle cramps needs to be explained in the
discussion session (PMID: 31864971).
4. Levocarnitine also improves mortality in patients with cirrhosis. The authors should add a
discussion in this point (PMID: 35511698).
assistant