Reviewer's report 
 Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic Title: 
syndrome? 
 1  3 July 2005 Version: Date: 
 Stanley Robboy Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
Leiomyomatosis peritonealis disseminata (LPD) is a fascinating disease about which little is known. 
This is the first report describing the disease as a genetically inheritable disease, and also one of a 
few reports describing the disease in men. The report is concise, well written, and well documented. 
The following comments are all minor. 
Case history: 
1) Are the lesions estrogen and progestin receptor positive? Is this information known? If not, would 
it be feasible to have receptor studies done using conventional immunohistochemical techniques? 
Were any other immunohistochemical studies performed, such as smooth muscle actin? 2) The lesions histology should also be documented with a good photomicrograph. 
Figure 1: Use only the best of the four photographs. Please crop the single photograph and 
demarcate the leiomyoma, possibly with an arrow. 
Figure 2: Much of the figure is wasted space. It is suggested that the central core of lesions be kept, 
and even possibly enlarged, while deleting the rest, which is most of the picture. Itch is misspelled in 
the legend (misspelled as "icht"). 
 Accept after discretionary revisions What next?: 
 An article of outstanding merit and interest in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests' 
Reviewer's report 
 Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic Title: 
syndrome? 
 1  3 July 2005 Version: Date: 
 Stanley Robboy Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
Leiomyomatosis peritonealis disseminata (LPD) is a fascinating disease about which little is known. 
This is the first report describing the disease as a genetically inheritable disease, and also one of a 
few reports describing the disease in men. The report is concise, well written, and well documented. 
The following comments are all minor. 
Case history: 
1) Are the lesions estrogen and progestin receptor positive? Is this information known? If not, would 
it be feasible to have receptor studies done using conventional immunohistochemical techniques? 
Were any other immunohistochemical studies performed, such as smooth muscle actin? 2) The lesions histology should also be documented with a good photomicrograph. 
Figure 1: Use only the best of the four photographs. Please crop the single photograph and 
demarcate the leiomyoma, possibly with an arrow. 
Figure 2: Much of the figure is wasted space. It is suggested that the central core of lesions be kept, 
and even possibly enlarged, while deleting the rest, which is most of the picture. Itch is misspelled in 
the legend (misspelled as "icht"). 
 Accept after discretionary revisions What next?: 
 An article of outstanding merit and interest in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests' 
Please review this paper.
user
Reviewer's report 
 Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic Title: 
syndrome? 
 1  3 July 2005 Version: Date: 
 Stanley Robboy Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
Leiomyomatosis peritonealis disseminata (LPD) is a fascinating disease about which little is known. 
This is the first report describing the disease as a genetically inheritable disease, and also one of a 
few reports describing the disease in men. The report is concise, well written, and well documented. 
The following comments are all minor. 
Case history: 
1) Are the lesions estrogen and progestin receptor positive? Is this information known? If not, would 
it be feasible to have receptor studies done using conventional immunohistochemical techniques? 
Were any other immunohistochemical studies performed, such as smooth muscle actin? 2) The lesions histology should also be documented with a good photomicrograph. 
Figure 1: Use only the best of the four photographs. Please crop the single photograph and 
demarcate the leiomyoma, possibly with an arrow. 
Figure 2: Much of the figure is wasted space. It is suggested that the central core of lesions be kept, 
and even possibly enlarged, while deleting the rest, which is most of the picture. Itch is misspelled in 
the legend (misspelled as "icht"). 
 Accept after discretionary revisions What next?: 
 An article of outstanding merit and interest in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests' 
assistant