Title: Establishment of a prognostic signature based on fatty acid metabolism genes in HCC
associated with hepatitis B
Version: 4 Date: 12 Oct 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: * A link between FAM and HBV-associated HCC has been
described by authors, pointing to a possible treatment approach that targets FAM to prevent
the buildup of Tregs in the tumour microenvironment of HBV-associated HCC. Five
genes (ACADVL, ACAT1, ACSL3, ADH4, and ECI1) were found to demonstrate efficient
discrimination and prediction for the prognosis of HBV-associated HCC in both the TCGA
cohort and the validation cohort.
* After review the manuscript is more elaborated and easy to understand.
* The authors have provided suitable justifications/updates over the reviewer comments.
* This manuscripts meets the best practice after modifications.
* This will help the scientific community to take a step further in HBV associated HCC research.
ADDITIONAL REQUESTS/SUGGESTIONS:
The authors have elaborated the review comments and modified the manuscript where required."
Title: Establishment of a prognostic signature based on fatty acid metabolism genes in HCC
associated with hepatitis B
Version: 4 Date: 12 Oct 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: * A link between FAM and HBV-associated HCC has been
described by authors, pointing to a possible treatment approach that targets FAM to prevent
the buildup of Tregs in the tumour microenvironment of HBV-associated HCC. Five
genes (ACADVL, ACAT1, ACSL3, ADH4, and ECI1) were found to demonstrate efficient
discrimination and prediction for the prognosis of HBV-associated HCC in both the TCGA
cohort and the validation cohort.
* After review the manuscript is more elaborated and easy to understand.
* The authors have provided suitable justifications/updates over the reviewer comments.
* This manuscripts meets the best practice after modifications.
* This will help the scientific community to take a step further in HBV associated HCC research.
ADDITIONAL REQUESTS/SUGGESTIONS:
The authors have elaborated the review comments and modified the manuscript where required."
Please review this paper.
user
Title: Establishment of a prognostic signature based on fatty acid metabolism genes in HCC
associated with hepatitis B
Version: 4 Date: 12 Oct 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: * A link between FAM and HBV-associated HCC has been
described by authors, pointing to a possible treatment approach that targets FAM to prevent
the buildup of Tregs in the tumour microenvironment of HBV-associated HCC. Five
genes (ACADVL, ACAT1, ACSL3, ADH4, and ECI1) were found to demonstrate efficient
discrimination and prediction for the prognosis of HBV-associated HCC in both the TCGA
cohort and the validation cohort.
* After review the manuscript is more elaborated and easy to understand.
* The authors have provided suitable justifications/updates over the reviewer comments.
* This manuscripts meets the best practice after modifications.
* This will help the scientific community to take a step further in HBV associated HCC research.
ADDITIONAL REQUESTS/SUGGESTIONS:
The authors have elaborated the review comments and modified the manuscript where required."
assistant