Reviewer's report
Title:Polymorphisms in gene encoding TRPV1-receptor involved in pain
perception are unrelated to chronic pancreatitis in a Dutch population.
Version: 1Date:5 October 2009
Reviewer: Fred S Gorelick
Reviewer's report:
This study examines the potential contribution by TRPV1 to chronic pancreatitis.
The hypothesis appears to be that these mutations cause disease. In a mixed
etiology population of patients with chronic pancreatitis the authors found no
such association.
Comments
1) Most studies of chronic pancreatitis that have examined TRPV1 have linked it
to pain perception and not pancreatitis inflammation. The one study (15) linking it
to inflammation was as study of acute and not chronic inflammation. Also, these
were studies in knockouts and compensation by other receptors could not be
excluded. These issues need to be discussed.
2) The study appears to be organized to address the issue "are polymorphisms in
TRV1 associated with chronic pancreatitis" in a broad sense, but an equally
important issue (suggested by most studies) would be "is is associated with
pain? This is a much more difficult study to do than the one undertaken by these
authors-they would have to find patients with other manifestations of chronic
pancreatitis (calcification, insufficiency, similar duration and etiology) and ask
whether the levels of pain differs. At a minimum this issue needs to be discussed.
Although their population is small, it might be worthwhile assessing whether
pancreatitis pain differed in accordance with TRPV1 polymorphisms.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Polymorphisms in gene encoding TRPV1-receptor involved in pain
perception are unrelated to chronic pancreatitis in a Dutch population.
Version: 1Date:5 October 2009
Reviewer: Fred S Gorelick
Reviewer's report:
This study examines the potential contribution by TRPV1 to chronic pancreatitis.
The hypothesis appears to be that these mutations cause disease. In a mixed
etiology population of patients with chronic pancreatitis the authors found no
such association.
Comments
1) Most studies of chronic pancreatitis that have examined TRPV1 have linked it
to pain perception and not pancreatitis inflammation. The one study (15) linking it
to inflammation was as study of acute and not chronic inflammation. Also, these
were studies in knockouts and compensation by other receptors could not be
excluded. These issues need to be discussed.
2) The study appears to be organized to address the issue "are polymorphisms in
TRV1 associated with chronic pancreatitis" in a broad sense, but an equally
important issue (suggested by most studies) would be "is is associated with
pain? This is a much more difficult study to do than the one undertaken by these
authors-they would have to find patients with other manifestations of chronic
pancreatitis (calcification, insufficiency, similar duration and etiology) and ask
whether the levels of pain differs. At a minimum this issue needs to be discussed.
Although their population is small, it might be worthwhile assessing whether
pancreatitis pain differed in accordance with TRPV1 polymorphisms.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Polymorphisms in gene encoding TRPV1-receptor involved in pain
perception are unrelated to chronic pancreatitis in a Dutch population.
Version: 1Date:5 October 2009
Reviewer: Fred S Gorelick
Reviewer's report:
This study examines the potential contribution by TRPV1 to chronic pancreatitis.
The hypothesis appears to be that these mutations cause disease. In a mixed
etiology population of patients with chronic pancreatitis the authors found no
such association.
Comments
1) Most studies of chronic pancreatitis that have examined TRPV1 have linked it
to pain perception and not pancreatitis inflammation. The one study (15) linking it
to inflammation was as study of acute and not chronic inflammation. Also, these
were studies in knockouts and compensation by other receptors could not be
excluded. These issues need to be discussed.
2) The study appears to be organized to address the issue "are polymorphisms in
TRV1 associated with chronic pancreatitis" in a broad sense, but an equally
important issue (suggested by most studies) would be "is is associated with
pain? This is a much more difficult study to do than the one undertaken by these
authors-they would have to find patients with other manifestations of chronic
pancreatitis (calcification, insufficiency, similar duration and etiology) and ask
whether the levels of pain differs. At a minimum this issue needs to be discussed.
Although their population is small, it might be worthwhile assessing whether
pancreatitis pain differed in accordance with TRPV1 polymorphisms.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant