Reviewer's report
Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in
Gastric Cancer: A Comprehensive Profiling Approach
Version: 1Date:26 August 2013
Reviewer: Juozas Kupcinskas
Reviewer's report:
A paper submitted by Loh et al. represents an original research, which adds
valuable information on methylation puzzle in gastric cancer. The authors use
novel high throughput technologies, which enabled to assess methylation status
in more than 1400 CpG sites. The methylation array used by the authors enables
to examine multiple methylation sites, rather than looking at single CpG island.
The authors describe two distinct methylation profiles in gastric cancer, which is
of interest for further research. The authors discuss their findings with
appropriate caution, reflecting on potential limitations and biases. The article is
written in comprehensible English. Statistical analysis is appropriate for methods
used within the study. I think that the article has adequate novelty and original
data; therefore, I would suggest accepting the paper for publishing.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in
Gastric Cancer: A Comprehensive Profiling Approach
Version: 1Date:26 August 2013
Reviewer: Juozas Kupcinskas
Reviewer's report:
A paper submitted by Loh et al. represents an original research, which adds
valuable information on methylation puzzle in gastric cancer. The authors use
novel high throughput technologies, which enabled to assess methylation status
in more than 1400 CpG sites. The methylation array used by the authors enables
to examine multiple methylation sites, rather than looking at single CpG island.
The authors describe two distinct methylation profiles in gastric cancer, which is
of interest for further research. The authors discuss their findings with
appropriate caution, reflecting on potential limitations and biases. The article is
written in comprehensible English. Statistical analysis is appropriate for methods
used within the study. I think that the article has adequate novelty and original
data; therefore, I would suggest accepting the paper for publishing.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:DNA Methylation Subgroups and the CpG Island Methylator Phenotype in
Gastric Cancer: A Comprehensive Profiling Approach
Version: 1Date:26 August 2013
Reviewer: Juozas Kupcinskas
Reviewer's report:
A paper submitted by Loh et al. represents an original research, which adds
valuable information on methylation puzzle in gastric cancer. The authors use
novel high throughput technologies, which enabled to assess methylation status
in more than 1400 CpG sites. The methylation array used by the authors enables
to examine multiple methylation sites, rather than looking at single CpG island.
The authors describe two distinct methylation profiles in gastric cancer, which is
of interest for further research. The authors discuss their findings with
appropriate caution, reflecting on potential limitations and biases. The article is
written in comprehensible English. Statistical analysis is appropriate for methods
used within the study. I think that the article has adequate novelty and original
data; therefore, I would suggest accepting the paper for publishing.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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