Reviewer's report
Title:Trace gluten contamination may play a role in mucosal and clinical
recovery in a subgroup of diet-adherent non-responsive celiac disease patients.
Version: 4Date:4 February 2013
Reviewer: Kamran Rostami
Reviewer's report:
This is a very interesting study with a very important message thoroughly written.
Despite the small number of patients recruited I like the concept of GCED and I
think this will be very usefull to many clinicians and nutritionists as a guide in how
to manage NRCD.
Minor comments:
Page 6 most of paragraph 2 should be in conclusion and discussion instead of
introduction.
Page 7 line 10 methods: Response to GCED defined as normal villous
architecture: as far as the current literature suggest, histological recovery is very
slow, unrelated to symptoms and hardly ever completeld in coeliac patients. The
definition of GCED therefore should be revised. Did some patients in this study
truly completely normalised in their histology? i would suggest the authors to
discuss their findings on histology correlated with the existence literature on
mucosal recovery.
Page 15 line 10: tTG serology does (should be doesn't)
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Trace gluten contamination may play a role in mucosal and clinical
recovery in a subgroup of diet-adherent non-responsive celiac disease patients.
Version: 4Date:4 February 2013
Reviewer: Kamran Rostami
Reviewer's report:
This is a very interesting study with a very important message thoroughly written.
Despite the small number of patients recruited I like the concept of GCED and I
think this will be very usefull to many clinicians and nutritionists as a guide in how
to manage NRCD.
Minor comments:
Page 6 most of paragraph 2 should be in conclusion and discussion instead of
introduction.
Page 7 line 10 methods: Response to GCED defined as normal villous
architecture: as far as the current literature suggest, histological recovery is very
slow, unrelated to symptoms and hardly ever completeld in coeliac patients. The
definition of GCED therefore should be revised. Did some patients in this study
truly completely normalised in their histology? i would suggest the authors to
discuss their findings on histology correlated with the existence literature on
mucosal recovery.
Page 15 line 10: tTG serology does (should be doesn't)
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Trace gluten contamination may play a role in mucosal and clinical
recovery in a subgroup of diet-adherent non-responsive celiac disease patients.
Version: 4Date:4 February 2013
Reviewer: Kamran Rostami
Reviewer's report:
This is a very interesting study with a very important message thoroughly written.
Despite the small number of patients recruited I like the concept of GCED and I
think this will be very usefull to many clinicians and nutritionists as a guide in how
to manage NRCD.
Minor comments:
Page 6 most of paragraph 2 should be in conclusion and discussion instead of
introduction.
Page 7 line 10 methods: Response to GCED defined as normal villous
architecture: as far as the current literature suggest, histological recovery is very
slow, unrelated to symptoms and hardly ever completeld in coeliac patients. The
definition of GCED therefore should be revised. Did some patients in this study
truly completely normalised in their histology? i would suggest the authors to
discuss their findings on histology correlated with the existence literature on
mucosal recovery.
Page 15 line 10: tTG serology does (should be doesn't)
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant