Title: Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk
factor of colorectal polyps: a retrospective study in China
Version: 2 Date: 06 Dec 2022
Reviewer's report:
The title of the article fully corresponds to the content and main conclusion. In the abstract in
the "Methods" section, it is advisable to indicate the number of examined patients, methods for
diagnosing colorectal polyps and atrophic gastritis.
In the “Introduction” section, the authors skillfully explain the feasibility of the study,
demonstrating a good knowledge of previous studies. Methods of work correspond to the
purpose of the study, allow to achieve objective results.
The authors examined 792 patients. Colorectal polyps were found in 385 people, atrophic
gastritis - in 332 patients. Multivariate analysis showed that age, gender, and atrophic gastritis
were independent risk factors for colorectal polyps. AUC for association of atrophic gastritis and
colorectal polyps was 0.62 (p<0.001), for Helicobacter pylori infection it was 0.57 (p<0.001).
The "Discussion" section is written in a good, clear language. The authors interpret the results
obtained in the light of previous studies and skillfully substantiate the novelty of the work and
the possible pathogenetic relationship between atrophic gastritis and colorectal polyps. The list
of references includes 31 works that are modern and allow substantiating the significance and
novelty of the study. There are no remarks on the quality of diagrams and illustrations. Ethical
requirements in accordance with the Declaration of Helsinki were observed in the work.
The work was performed using modern research methods on a large clinical material, which
made it possible to obtain original data on the direct relationship between atrophic gastritis and
colorectal polyps, which are of great practical and theoretical significance. The materials of
the article are presented in a good clear language. There are no significant comments on the
manuscript. The article may be published in the journal BMC Gastroenterology.
Title: Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk
factor of colorectal polyps: a retrospective study in China
Version: 2 Date: 06 Dec 2022
Reviewer's report:
The title of the article fully corresponds to the content and main conclusion. In the abstract in
the "Methods" section, it is advisable to indicate the number of examined patients, methods for
diagnosing colorectal polyps and atrophic gastritis.
In the “Introduction” section, the authors skillfully explain the feasibility of the study,
demonstrating a good knowledge of previous studies. Methods of work correspond to the
purpose of the study, allow to achieve objective results.
The authors examined 792 patients. Colorectal polyps were found in 385 people, atrophic
gastritis - in 332 patients. Multivariate analysis showed that age, gender, and atrophic gastritis
were independent risk factors for colorectal polyps. AUC for association of atrophic gastritis and
colorectal polyps was 0.62 (p<0.001), for Helicobacter pylori infection it was 0.57 (p<0.001).
The "Discussion" section is written in a good, clear language. The authors interpret the results
obtained in the light of previous studies and skillfully substantiate the novelty of the work and
the possible pathogenetic relationship between atrophic gastritis and colorectal polyps. The list
of references includes 31 works that are modern and allow substantiating the significance and
novelty of the study. There are no remarks on the quality of diagrams and illustrations. Ethical
requirements in accordance with the Declaration of Helsinki were observed in the work.
The work was performed using modern research methods on a large clinical material, which
made it possible to obtain original data on the direct relationship between atrophic gastritis and
colorectal polyps, which are of great practical and theoretical significance. The materials of
the article are presented in a good clear language. There are no significant comments on the
manuscript. The article may be published in the journal BMC Gastroenterology.
Please review this paper.
user
Title: Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk
factor of colorectal polyps: a retrospective study in China
Version: 2 Date: 06 Dec 2022
Reviewer's report:
The title of the article fully corresponds to the content and main conclusion. In the abstract in
the "Methods" section, it is advisable to indicate the number of examined patients, methods for
diagnosing colorectal polyps and atrophic gastritis.
In the “Introduction” section, the authors skillfully explain the feasibility of the study,
demonstrating a good knowledge of previous studies. Methods of work correspond to the
purpose of the study, allow to achieve objective results.
The authors examined 792 patients. Colorectal polyps were found in 385 people, atrophic
gastritis - in 332 patients. Multivariate analysis showed that age, gender, and atrophic gastritis
were independent risk factors for colorectal polyps. AUC for association of atrophic gastritis and
colorectal polyps was 0.62 (p<0.001), for Helicobacter pylori infection it was 0.57 (p<0.001).
The "Discussion" section is written in a good, clear language. The authors interpret the results
obtained in the light of previous studies and skillfully substantiate the novelty of the work and
the possible pathogenetic relationship between atrophic gastritis and colorectal polyps. The list
of references includes 31 works that are modern and allow substantiating the significance and
novelty of the study. There are no remarks on the quality of diagrams and illustrations. Ethical
requirements in accordance with the Declaration of Helsinki were observed in the work.
The work was performed using modern research methods on a large clinical material, which
made it possible to obtain original data on the direct relationship between atrophic gastritis and
colorectal polyps, which are of great practical and theoretical significance. The materials of
the article are presented in a good clear language. There are no significant comments on the
manuscript. The article may be published in the journal BMC Gastroenterology.
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