Title: Spatiotemporal Trends in Hernia Disease Burden and Health Workforce Correlations in
Aging Populations: A Global Analysis with Projections to 2050
Version: 0 Date: 03 Mar 2025
Reviewer's report:
The authors present a comprehensive analysis of inguinal, femoral, and abdominal wall hernias
in populations aged 45 and above. Drawing on data from the Global Burden of Disease 2021,
they explore incidence, prevalence, mortality, and disability-adjusted life years (DALYs) over
a 31-year period and project future trends up to 2050. They employ a variety of analytical tools,
including average annual percentage change (EAPC), decomposition methods, and age-period-
cohort (APC) analysis. Key findings include:
While age-standardized incidence and mortality rates have declined, the absolute disease burden
has risen due to population growth, aging, and socioeconomic disparities.
Countries with higher SDI report higher incidence but lower mortality, while lower SDI
countries face higher mortality and lower incidence.
The burden remains substantially higher in men than women, with male incidence rates more
than seven times higher.
Although the age-standardized rates are projected to increase only slightly, the absolute number
of new cases and deaths will continue to rise.
Once the following comments are adequately addressed, the manuscript will be even more
compelling and ready for publication:
The introduction would benefit from a deeper synthesis of prior studies to position this work
in the broader scientific context. Please elaborate on existing evidence regarding hernia risk
factors, trends, and management challenges, and clarify how your analysis addresses critical
gaps in the literature.
Maintain consistency in expressing numerical values throughout the text. Decide on a single
standard (e.g., one decimal place vs. two decimal places) and apply that format consistently.
In the Methods and Results sections, some abbreviations are defined multiple times. Provide
definitions only at their first mention, and use the abbreviations consistently afterward.
Your analysis highlights variations by socioeconomic status, age, and sex. Please expand further
on these disparities, explaining why certain populations or regions might face a heavier hernia
burden. This will help readers and policymakers better understand which interventions and
resources may be most beneficial in targeted settings.
Title: Spatiotemporal Trends in Hernia Disease Burden and Health Workforce Correlations in
Aging Populations: A Global Analysis with Projections to 2050
Version: 0 Date: 03 Mar 2025
Reviewer's report:
The authors present a comprehensive analysis of inguinal, femoral, and abdominal wall hernias
in populations aged 45 and above. Drawing on data from the Global Burden of Disease 2021,
they explore incidence, prevalence, mortality, and disability-adjusted life years (DALYs) over
a 31-year period and project future trends up to 2050. They employ a variety of analytical tools,
including average annual percentage change (EAPC), decomposition methods, and age-period-
cohort (APC) analysis. Key findings include:
While age-standardized incidence and mortality rates have declined, the absolute disease burden
has risen due to population growth, aging, and socioeconomic disparities.
Countries with higher SDI report higher incidence but lower mortality, while lower SDI
countries face higher mortality and lower incidence.
The burden remains substantially higher in men than women, with male incidence rates more
than seven times higher.
Although the age-standardized rates are projected to increase only slightly, the absolute number
of new cases and deaths will continue to rise.
Once the following comments are adequately addressed, the manuscript will be even more
compelling and ready for publication:
The introduction would benefit from a deeper synthesis of prior studies to position this work
in the broader scientific context. Please elaborate on existing evidence regarding hernia risk
factors, trends, and management challenges, and clarify how your analysis addresses critical
gaps in the literature.
Maintain consistency in expressing numerical values throughout the text. Decide on a single
standard (e.g., one decimal place vs. two decimal places) and apply that format consistently.
In the Methods and Results sections, some abbreviations are defined multiple times. Provide
definitions only at their first mention, and use the abbreviations consistently afterward.
Your analysis highlights variations by socioeconomic status, age, and sex. Please expand further
on these disparities, explaining why certain populations or regions might face a heavier hernia
burden. This will help readers and policymakers better understand which interventions and
resources may be most beneficial in targeted settings.
Please review this paper.
user
Title: Spatiotemporal Trends in Hernia Disease Burden and Health Workforce Correlations in
Aging Populations: A Global Analysis with Projections to 2050
Version: 0 Date: 03 Mar 2025
Reviewer's report:
The authors present a comprehensive analysis of inguinal, femoral, and abdominal wall hernias
in populations aged 45 and above. Drawing on data from the Global Burden of Disease 2021,
they explore incidence, prevalence, mortality, and disability-adjusted life years (DALYs) over
a 31-year period and project future trends up to 2050. They employ a variety of analytical tools,
including average annual percentage change (EAPC), decomposition methods, and age-period-
cohort (APC) analysis. Key findings include:
While age-standardized incidence and mortality rates have declined, the absolute disease burden
has risen due to population growth, aging, and socioeconomic disparities.
Countries with higher SDI report higher incidence but lower mortality, while lower SDI
countries face higher mortality and lower incidence.
The burden remains substantially higher in men than women, with male incidence rates more
than seven times higher.
Although the age-standardized rates are projected to increase only slightly, the absolute number
of new cases and deaths will continue to rise.
Once the following comments are adequately addressed, the manuscript will be even more
compelling and ready for publication:
The introduction would benefit from a deeper synthesis of prior studies to position this work
in the broader scientific context. Please elaborate on existing evidence regarding hernia risk
factors, trends, and management challenges, and clarify how your analysis addresses critical
gaps in the literature.
Maintain consistency in expressing numerical values throughout the text. Decide on a single
standard (e.g., one decimal place vs. two decimal places) and apply that format consistently.
In the Methods and Results sections, some abbreviations are defined multiple times. Provide
definitions only at their first mention, and use the abbreviations consistently afterward.
Your analysis highlights variations by socioeconomic status, age, and sex. Please expand further
on these disparities, explaining why certain populations or regions might face a heavier hernia
burden. This will help readers and policymakers better understand which interventions and
resources may be most beneficial in targeted settings.
assistant