Title: The PSC Scientific Community Resource: An Asset for Multi-omics Interrogation of
Primary Sclerosing Cholangitis
Version: 1 Date: 20 Jul 2021
Reviewer's report:
In this study, Ali et al. seek to establish the new data sets of PSC patients and control individuals.
PSC is a rare disorder and it is important to facilitate PSC research by sharing data and samples
with researchers in basic science who has limited access to samples/tissues of PSC patients.
I do not have any major criticism for this manuscript except a few minor comments. PSC is
characterized by liver fibrosis, inflammation, and ductular reaction (bile duct hyperplasia). It
seems that the authors do not include these characteristics (e.g., fibrosis levels). Is there any
reason? Scientists may use shared tissue samples and analyze liver fibrosis levels. Is it possible
for other scientists to add another parameter in the dataset (e.g., fibrosis levels) and share data
with others (e.g., histological images for Sirius Red staining)? How do the authors make it?
Open the website/portal/cloud or something that approved users can access and edit/add data,
or do the authors do not want to do that way? I feel like that it is unclear how the authors share
datasets with researchers, how they expand, and how they use them.
Title: The PSC Scientific Community Resource: An Asset for Multi-omics Interrogation of
Primary Sclerosing Cholangitis
Version: 1 Date: 20 Jul 2021
Reviewer's report:
In this study, Ali et al. seek to establish the new data sets of PSC patients and control individuals.
PSC is a rare disorder and it is important to facilitate PSC research by sharing data and samples
with researchers in basic science who has limited access to samples/tissues of PSC patients.
I do not have any major criticism for this manuscript except a few minor comments. PSC is
characterized by liver fibrosis, inflammation, and ductular reaction (bile duct hyperplasia). It
seems that the authors do not include these characteristics (e.g., fibrosis levels). Is there any
reason? Scientists may use shared tissue samples and analyze liver fibrosis levels. Is it possible
for other scientists to add another parameter in the dataset (e.g., fibrosis levels) and share data
with others (e.g., histological images for Sirius Red staining)? How do the authors make it?
Open the website/portal/cloud or something that approved users can access and edit/add data,
or do the authors do not want to do that way? I feel like that it is unclear how the authors share
datasets with researchers, how they expand, and how they use them.
Please review this paper.
user
Title: The PSC Scientific Community Resource: An Asset for Multi-omics Interrogation of
Primary Sclerosing Cholangitis
Version: 1 Date: 20 Jul 2021
Reviewer's report:
In this study, Ali et al. seek to establish the new data sets of PSC patients and control individuals.
PSC is a rare disorder and it is important to facilitate PSC research by sharing data and samples
with researchers in basic science who has limited access to samples/tissues of PSC patients.
I do not have any major criticism for this manuscript except a few minor comments. PSC is
characterized by liver fibrosis, inflammation, and ductular reaction (bile duct hyperplasia). It
seems that the authors do not include these characteristics (e.g., fibrosis levels). Is there any
reason? Scientists may use shared tissue samples and analyze liver fibrosis levels. Is it possible
for other scientists to add another parameter in the dataset (e.g., fibrosis levels) and share data
with others (e.g., histological images for Sirius Red staining)? How do the authors make it?
Open the website/portal/cloud or something that approved users can access and edit/add data,
or do the authors do not want to do that way? I feel like that it is unclear how the authors share
datasets with researchers, how they expand, and how they use them.
assistant