Reviewer's report
Title:Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor
pylori seropositivity, gastric atrophy and gastric cancer in Japanese
Version: 3Date:12 January 2009
Reviewer: charles S rabkin
Reviewer's report:
The revised manuscript has not answered our original criticism. The Abstract still
states, "Distribution of the genotype in patients with gastric cancer was similar to
that for those with gastric atrophy." This comparison is arbitrary and misleading,
since atrophy (i.e., mild+severe) is not significantly different from no atrophy. The
non-significant comparison of gastric cancer to no atrophy and the increased
odds ratio for gastric cancer compared to severe atrophy support a very different
interpretation. At the very least, the Abstract should include the authors' response
statement that "...those with the A/A genotype of PTPN11 rs2301756
polymorphism are at lower risk of severe gastric atrophy, but not associated with
the decreased risk of gastric cancer."
Furthermore, we support Dr. Ghoshal's comment #7 requesting a satisfactory
explanation of these paradoxical observations. The revised manuscript has not
yet adequately addressed our common concern.
/s/ Charles S Rabkin MD and Gwen Murphy PhD
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
We declare that we have no competing interests.
Reviewer's report
Title:Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor
pylori seropositivity, gastric atrophy and gastric cancer in Japanese
Version: 3Date:12 January 2009
Reviewer: charles S rabkin
Reviewer's report:
The revised manuscript has not answered our original criticism. The Abstract still
states, "Distribution of the genotype in patients with gastric cancer was similar to
that for those with gastric atrophy." This comparison is arbitrary and misleading,
since atrophy (i.e., mild+severe) is not significantly different from no atrophy. The
non-significant comparison of gastric cancer to no atrophy and the increased
odds ratio for gastric cancer compared to severe atrophy support a very different
interpretation. At the very least, the Abstract should include the authors' response
statement that "...those with the A/A genotype of PTPN11 rs2301756
polymorphism are at lower risk of severe gastric atrophy, but not associated with
the decreased risk of gastric cancer."
Furthermore, we support Dr. Ghoshal's comment #7 requesting a satisfactory
explanation of these paradoxical observations. The revised manuscript has not
yet adequately addressed our common concern.
/s/ Charles S Rabkin MD and Gwen Murphy PhD
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
We declare that we have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor
pylori seropositivity, gastric atrophy and gastric cancer in Japanese
Version: 3Date:12 January 2009
Reviewer: charles S rabkin
Reviewer's report:
The revised manuscript has not answered our original criticism. The Abstract still
states, "Distribution of the genotype in patients with gastric cancer was similar to
that for those with gastric atrophy." This comparison is arbitrary and misleading,
since atrophy (i.e., mild+severe) is not significantly different from no atrophy. The
non-significant comparison of gastric cancer to no atrophy and the increased
odds ratio for gastric cancer compared to severe atrophy support a very different
interpretation. At the very least, the Abstract should include the authors' response
statement that "...those with the A/A genotype of PTPN11 rs2301756
polymorphism are at lower risk of severe gastric atrophy, but not associated with
the decreased risk of gastric cancer."
Furthermore, we support Dr. Ghoshal's comment #7 requesting a satisfactory
explanation of these paradoxical observations. The revised manuscript has not
yet adequately addressed our common concern.
/s/ Charles S Rabkin MD and Gwen Murphy PhD
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
We declare that we have no competing interests.
assistant