Title: Relationship between Sarcopenia and Minimal Hepatic Encephalopathy in Patients with
Cirrhosis: A Prospective Observational Study
Version: 0 Date: 16 Dec 2024
Reviewer's report:
Comments to Authors:
1.There are numerous studies on the role of sarcopenia in predicting minimal hepatic
encephalopathy in cirrhotic patients, scientific novelty of this study is limited in my view.
2.Please mention ethical committee registration number
3.The authors have assessed muscle mass by using bioelectrical impedance analysis, more
objective and quantitative assessment of muscle mass by CT could have been done in these
patients.
4.Authors have not assessed the serum ammonia and Serum BCAA levels which might be
confounding factor for minimal hepatic encephalopathy.
5.Authors have excluded ascites in their study population,then why 6.7 % patients were taking
diuretics,please clarify.
6. Although majority of patients were CTP A, the prevalence of minimal hepatic encephalopathy
is substantially low as compared to previous studies, few studies had recorded the prevalence
of MHE in more than 50% of their study population.
7.Authors had not incuded CTP score and MELD score in logistic regression analysis for
predicting minimal hepatic encephalopathy. Numerous studies have shown CTP score was a
significant independent predictor of MHE.
8.There are lots of typographical errors,which needs to be corrected.
Title: Relationship between Sarcopenia and Minimal Hepatic Encephalopathy in Patients with
Cirrhosis: A Prospective Observational Study
Version: 0 Date: 16 Dec 2024
Reviewer's report:
Comments to Authors:
1.There are numerous studies on the role of sarcopenia in predicting minimal hepatic
encephalopathy in cirrhotic patients, scientific novelty of this study is limited in my view.
2.Please mention ethical committee registration number
3.The authors have assessed muscle mass by using bioelectrical impedance analysis, more
objective and quantitative assessment of muscle mass by CT could have been done in these
patients.
4.Authors have not assessed the serum ammonia and Serum BCAA levels which might be
confounding factor for minimal hepatic encephalopathy.
5.Authors have excluded ascites in their study population,then why 6.7 % patients were taking
diuretics,please clarify.
6. Although majority of patients were CTP A, the prevalence of minimal hepatic encephalopathy
is substantially low as compared to previous studies, few studies had recorded the prevalence
of MHE in more than 50% of their study population.
7.Authors had not incuded CTP score and MELD score in logistic regression analysis for
predicting minimal hepatic encephalopathy. Numerous studies have shown CTP score was a
significant independent predictor of MHE.
8.There are lots of typographical errors,which needs to be corrected.
Please review this paper.
user
Title: Relationship between Sarcopenia and Minimal Hepatic Encephalopathy in Patients with
Cirrhosis: A Prospective Observational Study
Version: 0 Date: 16 Dec 2024
Reviewer's report:
Comments to Authors:
1.There are numerous studies on the role of sarcopenia in predicting minimal hepatic
encephalopathy in cirrhotic patients, scientific novelty of this study is limited in my view.
2.Please mention ethical committee registration number
3.The authors have assessed muscle mass by using bioelectrical impedance analysis, more
objective and quantitative assessment of muscle mass by CT could have been done in these
patients.
4.Authors have not assessed the serum ammonia and Serum BCAA levels which might be
confounding factor for minimal hepatic encephalopathy.
5.Authors have excluded ascites in their study population,then why 6.7 % patients were taking
diuretics,please clarify.
6. Although majority of patients were CTP A, the prevalence of minimal hepatic encephalopathy
is substantially low as compared to previous studies, few studies had recorded the prevalence
of MHE in more than 50% of their study population.
7.Authors had not incuded CTP score and MELD score in logistic regression analysis for
predicting minimal hepatic encephalopathy. Numerous studies have shown CTP score was a
significant independent predictor of MHE.
8.There are lots of typographical errors,which needs to be corrected.
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