Title: Comparison of conventional MRI analysis versus MRI-based radiomics to predict the
circumferential margin resection involvement of rectal cancer
Version: 1 Date: 29 Jan 2024
Reviewer:  Svetlana Balyasnikova
Reviewer's report:
Dear Authors,
Thank you for your analysis,
It is critical to correctly stratify patient according to their imaging risk factors into group who
would require and benefit from neoadjuvant CRT and those who are unlikely to get any benefit.
It has been proven that MRI is efficient and robust methos or assessing the primary rectal tumour
including the CRM status pre and post CRT. In order to get accurate diagnosis on MRI high-
resolution images are required. Only high resolution T2-sequences enable accurate identification
of fine details and therefore findings appropriate patient for surgical treatment along of combined
with preoperative therapy.
Unfortunately looking at your data, I can see that you used not high-resolution MRI protocols,
meaning that accuracy of you T2-images is suboptimal. Therefore, it can not be considered as
standard, and analysis seems to be done incorrectly. Please consider repeating the analysis on
the high-resolution MRI to compared results of conventional assessment vs radiomics.
Title: Comparison of conventional MRI analysis versus MRI-based radiomics to predict the
circumferential margin resection involvement of rectal cancer
Version: 1 Date: 29 Jan 2024
Reviewer:  Svetlana Balyasnikova
Reviewer's report:
Dear Authors,
Thank you for your analysis,
It is critical to correctly stratify patient according to their imaging risk factors into group who
would require and benefit from neoadjuvant CRT and those who are unlikely to get any benefit.
It has been proven that MRI is efficient and robust methos or assessing the primary rectal tumour
including the CRM status pre and post CRT. In order to get accurate diagnosis on MRI high-
resolution images are required. Only high resolution T2-sequences enable accurate identification
of fine details and therefore findings appropriate patient for surgical treatment along of combined
with preoperative therapy.
Unfortunately looking at your data, I can see that you used not high-resolution MRI protocols,
meaning that accuracy of you T2-images is suboptimal. Therefore, it can not be considered as
standard, and analysis seems to be done incorrectly. Please consider repeating the analysis on
the high-resolution MRI to compared results of conventional assessment vs radiomics.
Please review this paper.
user
Title: Comparison of conventional MRI analysis versus MRI-based radiomics to predict the
circumferential margin resection involvement of rectal cancer
Version: 1 Date: 29 Jan 2024
Reviewer:  Svetlana Balyasnikova
Reviewer's report:
Dear Authors,
Thank you for your analysis,
It is critical to correctly stratify patient according to their imaging risk factors into group who
would require and benefit from neoadjuvant CRT and those who are unlikely to get any benefit.
It has been proven that MRI is efficient and robust methos or assessing the primary rectal tumour
including the CRM status pre and post CRT. In order to get accurate diagnosis on MRI high-
resolution images are required. Only high resolution T2-sequences enable accurate identification
of fine details and therefore findings appropriate patient for surgical treatment along of combined
with preoperative therapy.
Unfortunately looking at your data, I can see that you used not high-resolution MRI protocols,
meaning that accuracy of you T2-images is suboptimal. Therefore, it can not be considered as
standard, and analysis seems to be done incorrectly. Please consider repeating the analysis on
the high-resolution MRI to compared results of conventional assessment vs radiomics.
assistant