Title: Association of serum albumin-to-creatinine ratio with in-hospital mortality in patients
with severe acute pancreatitis: a retrospective study
Version: 2 Date: 13 Aug 2024
Reviewer's report:
I am delighted to review an article entitled " Association of serum albumin-to-creatinine ratio
with in-hospital mortality in patients with severe acute pancreatitis: a retrospective study." This
manuscript is a paper which examined the prognosis of patients with SAP. This paper revealed
that usefulness of serum albumin-to-creatinine ratio with the in-hospital death of SAP. This
manuscript is very interesting. However, author should consider several points.
Major point
We agree that the serum albumin indirectly reflects inflammation and is a useful prognostic
factor for pancreatitis. However, in Table 1, creatinine and sACR were significantly different
in the survivors and non-survivors, while albumin levels were not significantly different. Is
creatinine the greater contributor to in-hospital mortality in SAP patients? The authors performed
ROC analysis only for sACR, we suggest additional ROC analysis for the creatinine with
significant difference. In addition, ROC analysis of the BISAP score, which has already been
shown to be useful, may allow comparison of its usefulness with the sACR.
Minor point
Because SAP is the condition requiring intensive care, the SOFA and APACHE2 score should
also be mentioned in Table 1 and 2.
Title: Association of serum albumin-to-creatinine ratio with in-hospital mortality in patients
with severe acute pancreatitis: a retrospective study
Version: 2 Date: 13 Aug 2024
Reviewer's report:
I am delighted to review an article entitled " Association of serum albumin-to-creatinine ratio
with in-hospital mortality in patients with severe acute pancreatitis: a retrospective study." This
manuscript is a paper which examined the prognosis of patients with SAP. This paper revealed
that usefulness of serum albumin-to-creatinine ratio with the in-hospital death of SAP. This
manuscript is very interesting. However, author should consider several points.
Major point
We agree that the serum albumin indirectly reflects inflammation and is a useful prognostic
factor for pancreatitis. However, in Table 1, creatinine and sACR were significantly different
in the survivors and non-survivors, while albumin levels were not significantly different. Is
creatinine the greater contributor to in-hospital mortality in SAP patients? The authors performed
ROC analysis only for sACR, we suggest additional ROC analysis for the creatinine with
significant difference. In addition, ROC analysis of the BISAP score, which has already been
shown to be useful, may allow comparison of its usefulness with the sACR.
Minor point
Because SAP is the condition requiring intensive care, the SOFA and APACHE2 score should
also be mentioned in Table 1 and 2.
Please review this paper.
user
Title: Association of serum albumin-to-creatinine ratio with in-hospital mortality in patients
with severe acute pancreatitis: a retrospective study
Version: 2 Date: 13 Aug 2024
Reviewer's report:
I am delighted to review an article entitled " Association of serum albumin-to-creatinine ratio
with in-hospital mortality in patients with severe acute pancreatitis: a retrospective study." This
manuscript is a paper which examined the prognosis of patients with SAP. This paper revealed
that usefulness of serum albumin-to-creatinine ratio with the in-hospital death of SAP. This
manuscript is very interesting. However, author should consider several points.
Major point
We agree that the serum albumin indirectly reflects inflammation and is a useful prognostic
factor for pancreatitis. However, in Table 1, creatinine and sACR were significantly different
in the survivors and non-survivors, while albumin levels were not significantly different. Is
creatinine the greater contributor to in-hospital mortality in SAP patients? The authors performed
ROC analysis only for sACR, we suggest additional ROC analysis for the creatinine with
significant difference. In addition, ROC analysis of the BISAP score, which has already been
shown to be useful, may allow comparison of its usefulness with the sACR.
Minor point
Because SAP is the condition requiring intensive care, the SOFA and APACHE2 score should
also be mentioned in Table 1 and 2.
assistant