Title: Clinical and Demographic Analysis of Patients with Colorectal Cancer Screened at a
Reference Hospital in Southern Brazil: Comparative Study Based on age (Retrospective Cohort
Study)
Version: 4 Date: 07 Dec 2024
Reviewer's report:
Review of Manuscript 11-30-24
Clinical and Demographic Analysis of Patients with Colorectal Cancer Screened at a Reference
Hospital in Southern Brazil: Comparative Study Based on age (Retrospective Cohort Study)
This is a retrospective study of 1,121 pts with CRC who were evaluated for differences in clinical
and demographic factors comparing the age of the pts being <50 years of age vs >50 years of age.
The findings with significant differences included the number of pts <50 who were active
smokers 40% vs 15% > 50 years, the number presenting with obstruction/subocclusion, and the
number <50 who presented with bleeding, 14% vs 2.4%. Gender, stage of disease, laterality,
FH, ethnicity, CEA, adjuvant rx, white cell ratios, alcoholism, etc. showed NSD, whereas
similar studies in North America have often shown statistical differences for stage of disease,
distal disease, more women, and more non-Caucasians. Their findings may represent important
differences for their population.
The authors have identified a particularly damaging association of smoking with CRC which
provides a target for preventative measures as well as demonstrating a prototype for their region.
The findings show appreciable variables from other large studies of early- and late-onset CRC
outside of Brazil and may set a somewhat different guideline for this area of southern Brazil.
In order to compare their results to other publications, it might be helpful to indicate precisely
where the demarcation for proximal vs distal colon was made.
Since CEA was tested extensively, could the CEA levels be compared to subsets of pts, e.g.,
who smoked, had differing stages of disease, clinical presentations, etc.?
Are the authors aware of any similar studies from their population area for comparison to their
data? If so, how do they compare?
Title: Clinical and Demographic Analysis of Patients with Colorectal Cancer Screened at a
Reference Hospital in Southern Brazil: Comparative Study Based on age (Retrospective Cohort
Study)
Version: 4 Date: 07 Dec 2024
Reviewer's report:
Review of Manuscript 11-30-24
Clinical and Demographic Analysis of Patients with Colorectal Cancer Screened at a Reference
Hospital in Southern Brazil: Comparative Study Based on age (Retrospective Cohort Study)
This is a retrospective study of 1,121 pts with CRC who were evaluated for differences in clinical
and demographic factors comparing the age of the pts being <50 years of age vs >50 years of age.
The findings with significant differences included the number of pts <50 who were active
smokers 40% vs 15% > 50 years, the number presenting with obstruction/subocclusion, and the
number <50 who presented with bleeding, 14% vs 2.4%. Gender, stage of disease, laterality,
FH, ethnicity, CEA, adjuvant rx, white cell ratios, alcoholism, etc. showed NSD, whereas
similar studies in North America have often shown statistical differences for stage of disease,
distal disease, more women, and more non-Caucasians. Their findings may represent important
differences for their population.
The authors have identified a particularly damaging association of smoking with CRC which
provides a target for preventative measures as well as demonstrating a prototype for their region.
The findings show appreciable variables from other large studies of early- and late-onset CRC
outside of Brazil and may set a somewhat different guideline for this area of southern Brazil.
In order to compare their results to other publications, it might be helpful to indicate precisely
where the demarcation for proximal vs distal colon was made.
Since CEA was tested extensively, could the CEA levels be compared to subsets of pts, e.g.,
who smoked, had differing stages of disease, clinical presentations, etc.?
Are the authors aware of any similar studies from their population area for comparison to their
data? If so, how do they compare?
Please review this paper.
user
Title: Clinical and Demographic Analysis of Patients with Colorectal Cancer Screened at a
Reference Hospital in Southern Brazil: Comparative Study Based on age (Retrospective Cohort
Study)
Version: 4 Date: 07 Dec 2024
Reviewer's report:
Review of Manuscript 11-30-24
Clinical and Demographic Analysis of Patients with Colorectal Cancer Screened at a Reference
Hospital in Southern Brazil: Comparative Study Based on age (Retrospective Cohort Study)
This is a retrospective study of 1,121 pts with CRC who were evaluated for differences in clinical
and demographic factors comparing the age of the pts being <50 years of age vs >50 years of age.
The findings with significant differences included the number of pts <50 who were active
smokers 40% vs 15% > 50 years, the number presenting with obstruction/subocclusion, and the
number <50 who presented with bleeding, 14% vs 2.4%. Gender, stage of disease, laterality,
FH, ethnicity, CEA, adjuvant rx, white cell ratios, alcoholism, etc. showed NSD, whereas
similar studies in North America have often shown statistical differences for stage of disease,
distal disease, more women, and more non-Caucasians. Their findings may represent important
differences for their population.
The authors have identified a particularly damaging association of smoking with CRC which
provides a target for preventative measures as well as demonstrating a prototype for their region.
The findings show appreciable variables from other large studies of early- and late-onset CRC
outside of Brazil and may set a somewhat different guideline for this area of southern Brazil.
In order to compare their results to other publications, it might be helpful to indicate precisely
where the demarcation for proximal vs distal colon was made.
Since CEA was tested extensively, could the CEA levels be compared to subsets of pts, e.g.,
who smoked, had differing stages of disease, clinical presentations, etc.?
Are the authors aware of any similar studies from their population area for comparison to their
data? If so, how do they compare?
assistant