Reviewer's report
Title:A simple index of lipid overaccumulation is a good marker of liver steatosis
Version: 2Date:30 June 2010
Reviewer: Giovanni Targher
Reviewer's report:
In this cross-sectional study, Dr. Bedogni and colleagues examined the ability of
the lipid accumulation product (LAP) to identify hepatic steatosis in a subset of
588 adult individuals participating in the Dionysos project. The same study
population was previously used to develop the fatty liver index (FLI).
The authors found that LAP was a reasonably accurate index to recognizing
individuals with ultrasound-diagnosed hepatic steatosis.
Major comments
1. The manuscript is not always easy to read and the direct relevance of these
data to care or prevention of hepatic steatosis are not completely clear. A liver
ultrasound examination is essential to identify hepatic steatosis in routine clinical
practice and the LAP index simply reflects the presence of the metabolic
syndrome, which is a condition closely associated with hepatic steatosis.
2. The authors should show data comparing the ability of LAP and FLI to identify
hepatic steatosis.
3. Table 1. Please, include gender distribution, blood pressure, HDL-cholesterol
and the frequency of the ATP III-defined metabolic syndrome.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:A simple index of lipid overaccumulation is a good marker of liver steatosis
Version: 2Date:30 June 2010
Reviewer: Giovanni Targher
Reviewer's report:
In this cross-sectional study, Dr. Bedogni and colleagues examined the ability of
the lipid accumulation product (LAP) to identify hepatic steatosis in a subset of
588 adult individuals participating in the Dionysos project. The same study
population was previously used to develop the fatty liver index (FLI).
The authors found that LAP was a reasonably accurate index to recognizing
individuals with ultrasound-diagnosed hepatic steatosis.
Major comments
1. The manuscript is not always easy to read and the direct relevance of these
data to care or prevention of hepatic steatosis are not completely clear. A liver
ultrasound examination is essential to identify hepatic steatosis in routine clinical
practice and the LAP index simply reflects the presence of the metabolic
syndrome, which is a condition closely associated with hepatic steatosis.
2. The authors should show data comparing the ability of LAP and FLI to identify
hepatic steatosis.
3. Table 1. Please, include gender distribution, blood pressure, HDL-cholesterol
and the frequency of the ATP III-defined metabolic syndrome.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:A simple index of lipid overaccumulation is a good marker of liver steatosis
Version: 2Date:30 June 2010
Reviewer: Giovanni Targher
Reviewer's report:
In this cross-sectional study, Dr. Bedogni and colleagues examined the ability of
the lipid accumulation product (LAP) to identify hepatic steatosis in a subset of
588 adult individuals participating in the Dionysos project. The same study
population was previously used to develop the fatty liver index (FLI).
The authors found that LAP was a reasonably accurate index to recognizing
individuals with ultrasound-diagnosed hepatic steatosis.
Major comments
1. The manuscript is not always easy to read and the direct relevance of these
data to care or prevention of hepatic steatosis are not completely clear. A liver
ultrasound examination is essential to identify hepatic steatosis in routine clinical
practice and the LAP index simply reflects the presence of the metabolic
syndrome, which is a condition closely associated with hepatic steatosis.
2. The authors should show data comparing the ability of LAP and FLI to identify
hepatic steatosis.
3. Table 1. Please, include gender distribution, blood pressure, HDL-cholesterol
and the frequency of the ATP III-defined metabolic syndrome.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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