Title: Safety Comparison of Single-Donor and Pooled Fecal Microbiota Transfer Product
Preparation in Ulcerative Colitis: Systematic Review and Meta-Analysis
Version: 3 Date: 25 Sep 2024
Reviewer's report:
These study builds on earlier research investigating the efficacy of MDN vs SDN FMT strategies
for ulcerative colitis. The authors appear to have addressed the previous reviewer comments
appropriately, hence I won't revisit those.
The paper's results focus more broadly on overall AE and SAE rates for SDN vs MDN. As
has been mentioned previously, more granular analysis of the rates of individual AEs or SAEs
would be more informative. If the included studies do not uniformly stratify the overall AE/SAE
rates into individual AE/SAEs then this analysis will be difficult to perform. Having noted this
weakness, I would accept the manuscript in its current form.
Title: Safety Comparison of Single-Donor and Pooled Fecal Microbiota Transfer Product
Preparation in Ulcerative Colitis: Systematic Review and Meta-Analysis
Version: 3 Date: 25 Sep 2024
Reviewer's report:
These study builds on earlier research investigating the efficacy of MDN vs SDN FMT strategies
for ulcerative colitis. The authors appear to have addressed the previous reviewer comments
appropriately, hence I won't revisit those.
The paper's results focus more broadly on overall AE and SAE rates for SDN vs MDN. As
has been mentioned previously, more granular analysis of the rates of individual AEs or SAEs
would be more informative. If the included studies do not uniformly stratify the overall AE/SAE
rates into individual AE/SAEs then this analysis will be difficult to perform. Having noted this
weakness, I would accept the manuscript in its current form.
Please review this paper.
user
Title: Safety Comparison of Single-Donor and Pooled Fecal Microbiota Transfer Product
Preparation in Ulcerative Colitis: Systematic Review and Meta-Analysis
Version: 3 Date: 25 Sep 2024
Reviewer's report:
These study builds on earlier research investigating the efficacy of MDN vs SDN FMT strategies
for ulcerative colitis. The authors appear to have addressed the previous reviewer comments
appropriately, hence I won't revisit those.
The paper's results focus more broadly on overall AE and SAE rates for SDN vs MDN. As
has been mentioned previously, more granular analysis of the rates of individual AEs or SAEs
would be more informative. If the included studies do not uniformly stratify the overall AE/SAE
rates into individual AE/SAEs then this analysis will be difficult to perform. Having noted this
weakness, I would accept the manuscript in its current form.
assistant