Title: Upper gastrointestinal endoscopic findings in functional constipation and irritable bowel
syndrome diagnosed using the Rome IV criteria: a cross-sectional survey during a medical
check-up in Japan
Version: 0 Date: 16 Mar 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
The article described the EGD findings associated with FC and IBS patients who underwent
screening purposes in the Japanese cohort. The authors found that corpus erosion and read
streaks are significantly associated with FC, and erosive gastritis and duodenitis are significantly
associated with IBS. There is a trend of red lines and IBS. IBS with erosive and duodenitis has
more phycological factors and abdominal pain in this morphology. This unique study presents
an issue that has not been investigated previously, has high scientific soundness and is worth
publishing. However, there are some minor concerns about this article. 1. In this study’s design,
the authors should explain the definition of continuous use (p.6, line 15) (e.g., how many months/
years). Please briefly explain why acid secretion inhibitors are excluded from this study in the
discussion. 2. In the methods, the authors use GIF-XP290N (probably mainly for screening /
patient accessibility) as an endoscope. The authors may present the modalities (e.g., WLI/NBI/
indigo carmine) and procedure (e.g., no sedation). 3. Table 1 needs the unit(U/mL) for the serum
Hp antibody. 5. Please add arrows in the endoscopic pictures to explain the findings. I am very
interested in reading the article.
Title: Upper gastrointestinal endoscopic findings in functional constipation and irritable bowel
syndrome diagnosed using the Rome IV criteria: a cross-sectional survey during a medical
check-up in Japan
Version: 0 Date: 16 Mar 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
The article described the EGD findings associated with FC and IBS patients who underwent
screening purposes in the Japanese cohort. The authors found that corpus erosion and read
streaks are significantly associated with FC, and erosive gastritis and duodenitis are significantly
associated with IBS. There is a trend of red lines and IBS. IBS with erosive and duodenitis has
more phycological factors and abdominal pain in this morphology. This unique study presents
an issue that has not been investigated previously, has high scientific soundness and is worth
publishing. However, there are some minor concerns about this article. 1. In this study’s design,
the authors should explain the definition of continuous use (p.6, line 15) (e.g., how many months/
years). Please briefly explain why acid secretion inhibitors are excluded from this study in the
discussion. 2. In the methods, the authors use GIF-XP290N (probably mainly for screening /
patient accessibility) as an endoscope. The authors may present the modalities (e.g., WLI/NBI/
indigo carmine) and procedure (e.g., no sedation). 3. Table 1 needs the unit(U/mL) for the serum
Hp antibody. 5. Please add arrows in the endoscopic pictures to explain the findings. I am very
interested in reading the article.
Please review this paper.
user
Title: Upper gastrointestinal endoscopic findings in functional constipation and irritable bowel
syndrome diagnosed using the Rome IV criteria: a cross-sectional survey during a medical
check-up in Japan
Version: 0 Date: 16 Mar 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
The article described the EGD findings associated with FC and IBS patients who underwent
screening purposes in the Japanese cohort. The authors found that corpus erosion and read
streaks are significantly associated with FC, and erosive gastritis and duodenitis are significantly
associated with IBS. There is a trend of red lines and IBS. IBS with erosive and duodenitis has
more phycological factors and abdominal pain in this morphology. This unique study presents
an issue that has not been investigated previously, has high scientific soundness and is worth
publishing. However, there are some minor concerns about this article. 1. In this study’s design,
the authors should explain the definition of continuous use (p.6, line 15) (e.g., how many months/
years). Please briefly explain why acid secretion inhibitors are excluded from this study in the
discussion. 2. In the methods, the authors use GIF-XP290N (probably mainly for screening /
patient accessibility) as an endoscope. The authors may present the modalities (e.g., WLI/NBI/
indigo carmine) and procedure (e.g., no sedation). 3. Table 1 needs the unit(U/mL) for the serum
Hp antibody. 5. Please add arrows in the endoscopic pictures to explain the findings. I am very
interested in reading the article.
assistant