Title: Association between the lymphocyte-to-high-density lipoprotein ratio and Metabolic
dysfunction-associated steatotic liver disease among US adults: a cross-sectional study from
NHANES 2017 to 2020
Version: 1 Date: 05 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Definition of fibrosis should be provided as well as which way of analysis of CAP and
liver stiffness ( continuous or parametric) was selected Methods If possible protocol of patients
selection should be presented Exclusion criteria such as commorbidities, pregnancy or lacticion
should be defimed if they have been taken into consideration Timepoint of LHR determination
should be given and defined if a ratio of diffrenet measurements was utilized Timepoint of
transient elastography and time distance of LHR measurement should be defined Definition
of the parameters used should be provided In the statistical analysis it could be examined if
using  continuous measurements of liver stiffness might make a difference, as well as whether
instead of using one dichotomus variable using different values for F2,F3 and F4 fibrosis because
inflammation (MASH) is more related with fibrosis than steatosis
Title: Association between the lymphocyte-to-high-density lipoprotein ratio and Metabolic
dysfunction-associated steatotic liver disease among US adults: a cross-sectional study from
NHANES 2017 to 2020
Version: 1 Date: 05 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Definition of fibrosis should be provided as well as which way of analysis of CAP and
liver stiffness ( continuous or parametric) was selected Methods If possible protocol of patients
selection should be presented Exclusion criteria such as commorbidities, pregnancy or lacticion
should be defimed if they have been taken into consideration Timepoint of LHR determination
should be given and defined if a ratio of diffrenet measurements was utilized Timepoint of
transient elastography and time distance of LHR measurement should be defined Definition
of the parameters used should be provided In the statistical analysis it could be examined if
using  continuous measurements of liver stiffness might make a difference, as well as whether
instead of using one dichotomus variable using different values for F2,F3 and F4 fibrosis because
inflammation (MASH) is more related with fibrosis than steatosis
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Title: Association between the lymphocyte-to-high-density lipoprotein ratio and Metabolic
dysfunction-associated steatotic liver disease among US adults: a cross-sectional study from
NHANES 2017 to 2020
Version: 1 Date: 05 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Definition of fibrosis should be provided as well as which way of analysis of CAP and
liver stiffness ( continuous or parametric) was selected Methods If possible protocol of patients
selection should be presented Exclusion criteria such as commorbidities, pregnancy or lacticion
should be defimed if they have been taken into consideration Timepoint of LHR determination
should be given and defined if a ratio of diffrenet measurements was utilized Timepoint of
transient elastography and time distance of LHR measurement should be defined Definition
of the parameters used should be provided In the statistical analysis it could be examined if
using  continuous measurements of liver stiffness might make a difference, as well as whether
instead of using one dichotomus variable using different values for F2,F3 and F4 fibrosis because
inflammation (MASH) is more related with fibrosis than steatosis
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