Title: Association of Circulating Adipsin with Nonalcoholic Fatty Liver Disease in Obese
Adults: A Cross-Sectional Study
Version: 1 Date: 21 Jan 2021
Reviewer:  Norberto Chavez-tapia
Reviewer's report:
To the authors:
Jinhua Zhang, Kangli Li, Lingling Pan, Fei Teng, Bingquan Lin, Youwen Yuan, Xueyun Wei,
Peizhen Zhang, Wenyuan Li, Huijie Zhang.
I read the paper “Zhang J, Li K, Pan L, et al. Association of Circulating Adipsin with
Nonalcoholic Fatty Liver Disease in Obese Adults: A Cross-Sectional Study”, were the central
issue is the association of adipsin with NAFLD in obese adults. The key points that I find in
the paper is that the populations differ in the expected anthropometric parameters (like waist
circumference, BMI, triglycerides, total cholesterol, etc.). In the characteristics by quartiles of
serum adipsin, it seems that in fact, NAFLD is more prevalent in the upper quartile compare
with the others; and is demonstrated by performing the multivariate analysis.
The next points I consider can work and improve the paper.
- In the diagnosis of fatty liver disease by ultrasonography, please consider to analyze the intra-
observer variability.
- Please consider to use a semi-quantitative sonographic scoring, to perform sensitivity analysis.
Also include non-invasive markers of fibrosis and steatosis.
- At the results, consider create categories according the diagnostic criteria in clinical practice,
instead of quartiles.
- In the characteristics by quartiles, showed in the table 2, explain how the increase in adipsin
levels is associated with more waist circumference and body fat, but not with biochemical
markers of MtS, and less prevalence of NAFLD.
- Tables 3 and 4, are not enough clear to explain the concept.
- Table 3 does not provide clinical information to test the hypothesis.
- Why carotid intima-media thickness is included in table 5?
Title: Association of Circulating Adipsin with Nonalcoholic Fatty Liver Disease in Obese
Adults: A Cross-Sectional Study
Version: 1 Date: 21 Jan 2021
Reviewer:  Norberto Chavez-tapia
Reviewer's report:
To the authors:
Jinhua Zhang, Kangli Li, Lingling Pan, Fei Teng, Bingquan Lin, Youwen Yuan, Xueyun Wei,
Peizhen Zhang, Wenyuan Li, Huijie Zhang.
I read the paper “Zhang J, Li K, Pan L, et al. Association of Circulating Adipsin with
Nonalcoholic Fatty Liver Disease in Obese Adults: A Cross-Sectional Study”, were the central
issue is the association of adipsin with NAFLD in obese adults. The key points that I find in
the paper is that the populations differ in the expected anthropometric parameters (like waist
circumference, BMI, triglycerides, total cholesterol, etc.). In the characteristics by quartiles of
serum adipsin, it seems that in fact, NAFLD is more prevalent in the upper quartile compare
with the others; and is demonstrated by performing the multivariate analysis.
The next points I consider can work and improve the paper.
- In the diagnosis of fatty liver disease by ultrasonography, please consider to analyze the intra-
observer variability.
- Please consider to use a semi-quantitative sonographic scoring, to perform sensitivity analysis.
Also include non-invasive markers of fibrosis and steatosis.
- At the results, consider create categories according the diagnostic criteria in clinical practice,
instead of quartiles.
- In the characteristics by quartiles, showed in the table 2, explain how the increase in adipsin
levels is associated with more waist circumference and body fat, but not with biochemical
markers of MtS, and less prevalence of NAFLD.
- Tables 3 and 4, are not enough clear to explain the concept.
- Table 3 does not provide clinical information to test the hypothesis.
- Why carotid intima-media thickness is included in table 5?
Please review this paper.
user
Title: Association of Circulating Adipsin with Nonalcoholic Fatty Liver Disease in Obese
Adults: A Cross-Sectional Study
Version: 1 Date: 21 Jan 2021
Reviewer:  Norberto Chavez-tapia
Reviewer's report:
To the authors:
Jinhua Zhang, Kangli Li, Lingling Pan, Fei Teng, Bingquan Lin, Youwen Yuan, Xueyun Wei,
Peizhen Zhang, Wenyuan Li, Huijie Zhang.
I read the paper “Zhang J, Li K, Pan L, et al. Association of Circulating Adipsin with
Nonalcoholic Fatty Liver Disease in Obese Adults: A Cross-Sectional Study”, were the central
issue is the association of adipsin with NAFLD in obese adults. The key points that I find in
the paper is that the populations differ in the expected anthropometric parameters (like waist
circumference, BMI, triglycerides, total cholesterol, etc.). In the characteristics by quartiles of
serum adipsin, it seems that in fact, NAFLD is more prevalent in the upper quartile compare
with the others; and is demonstrated by performing the multivariate analysis.
The next points I consider can work and improve the paper.
- In the diagnosis of fatty liver disease by ultrasonography, please consider to analyze the intra-
observer variability.
- Please consider to use a semi-quantitative sonographic scoring, to perform sensitivity analysis.
Also include non-invasive markers of fibrosis and steatosis.
- At the results, consider create categories according the diagnostic criteria in clinical practice,
instead of quartiles.
- In the characteristics by quartiles, showed in the table 2, explain how the increase in adipsin
levels is associated with more waist circumference and body fat, but not with biochemical
markers of MtS, and less prevalence of NAFLD.
- Tables 3 and 4, are not enough clear to explain the concept.
- Table 3 does not provide clinical information to test the hypothesis.
- Why carotid intima-media thickness is included in table 5?
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