Title: Predictive value of adipokines for the severity of acute pancreatitis: a meta-analysis
Version: 4 Date: 10 Jul 2023
Reviewer's report:
The article deals with a very important topic, since severe acute pancreatitis is a life-threatening
condition, the timely discovery and prediction of which can affect the therapy.  Based on my
opininion here are my recommendations:
- In the introduction, not only the obesity but also the metabolic syndrome and the increased
risk for SAP (PMID: 31620021) and increased occurence of AP (PMID: 33407178) should be
mentioned.
-In the methods section, the search key is not complete, the supplementary table3 is not cited.
Was language restriction or other filters used during the search?
- Was the same definition of AP, SAP and MAP used in the articles?
-Although the conclusion is that resistin could be a biomarker for the detection of SAP, I miss the
mention of the use of score systems suitable for assessing SAP in the introduction and discussion.
PMID: 31507427, PMID: 31947993, PMID: 35653504
-How accessible is resistin as a marker? Could it be widely used? On its own or perhaps
integrated into score together with other parameters?
Based on these points, it is a major revision, the article needs to be revised.
Title: Predictive value of adipokines for the severity of acute pancreatitis: a meta-analysis
Version: 4 Date: 10 Jul 2023
Reviewer's report:
The article deals with a very important topic, since severe acute pancreatitis is a life-threatening
condition, the timely discovery and prediction of which can affect the therapy.  Based on my
opininion here are my recommendations:
- In the introduction, not only the obesity but also the metabolic syndrome and the increased
risk for SAP (PMID: 31620021) and increased occurence of AP (PMID: 33407178) should be
mentioned.
-In the methods section, the search key is not complete, the supplementary table3 is not cited.
Was language restriction or other filters used during the search?
- Was the same definition of AP, SAP and MAP used in the articles?
-Although the conclusion is that resistin could be a biomarker for the detection of SAP, I miss the
mention of the use of score systems suitable for assessing SAP in the introduction and discussion.
PMID: 31507427, PMID: 31947993, PMID: 35653504
-How accessible is resistin as a marker? Could it be widely used? On its own or perhaps
integrated into score together with other parameters?
Based on these points, it is a major revision, the article needs to be revised.
Please review this paper.
user
Title: Predictive value of adipokines for the severity of acute pancreatitis: a meta-analysis
Version: 4 Date: 10 Jul 2023
Reviewer's report:
The article deals with a very important topic, since severe acute pancreatitis is a life-threatening
condition, the timely discovery and prediction of which can affect the therapy.  Based on my
opininion here are my recommendations:
- In the introduction, not only the obesity but also the metabolic syndrome and the increased
risk for SAP (PMID: 31620021) and increased occurence of AP (PMID: 33407178) should be
mentioned.
-In the methods section, the search key is not complete, the supplementary table3 is not cited.
Was language restriction or other filters used during the search?
- Was the same definition of AP, SAP and MAP used in the articles?
-Although the conclusion is that resistin could be a biomarker for the detection of SAP, I miss the
mention of the use of score systems suitable for assessing SAP in the introduction and discussion.
PMID: 31507427, PMID: 31947993, PMID: 35653504
-How accessible is resistin as a marker? Could it be widely used? On its own or perhaps
integrated into score together with other parameters?
Based on these points, it is a major revision, the article needs to be revised.
assistant