Title: Prognostic nutritional index is an independent prognostic factor for older patients aged
#85 years treated by gastric endoscopic submucosal dissection
Version: 2 Date: 08 May 2021
Reviewer's report:
This study was retrospective study to investigate prognostic factors for survival after ESD in
older patients aged #85 years with EGC.
It is very interesting that high CCI was not found to be a prognostic factor, only low PNI was
an independent prognostic factor associated with OS. However, the authors should address the
following points.
Major#
##It was found that low PNI is an important independent prognostic factor after ESD in EGC,
but are there any data that low PNI was associated with other causes of death (cardiovascular and
pneumonia)?  The authors should add that description. If authors don't have the data, consider
including a reference that can explain them.
##There is a description of selection bias in the limitation section, but it is recommended to add
it in a little more detail. For example, "This study included only patients who were selected by
physicians, and excluded patients who could not undergo ESD because of severe CCI or poor
ECOG PS. ".
Title: Prognostic nutritional index is an independent prognostic factor for older patients aged
#85 years treated by gastric endoscopic submucosal dissection
Version: 2 Date: 08 May 2021
Reviewer's report:
This study was retrospective study to investigate prognostic factors for survival after ESD in
older patients aged #85 years with EGC.
It is very interesting that high CCI was not found to be a prognostic factor, only low PNI was
an independent prognostic factor associated with OS. However, the authors should address the
following points.
Major#
##It was found that low PNI is an important independent prognostic factor after ESD in EGC,
but are there any data that low PNI was associated with other causes of death (cardiovascular and
pneumonia)?  The authors should add that description. If authors don't have the data, consider
including a reference that can explain them.
##There is a description of selection bias in the limitation section, but it is recommended to add
it in a little more detail. For example, "This study included only patients who were selected by
physicians, and excluded patients who could not undergo ESD because of severe CCI or poor
ECOG PS. ".
Please review this paper.
user
Title: Prognostic nutritional index is an independent prognostic factor for older patients aged
#85 years treated by gastric endoscopic submucosal dissection
Version: 2 Date: 08 May 2021
Reviewer's report:
This study was retrospective study to investigate prognostic factors for survival after ESD in
older patients aged #85 years with EGC.
It is very interesting that high CCI was not found to be a prognostic factor, only low PNI was
an independent prognostic factor associated with OS. However, the authors should address the
following points.
Major#
##It was found that low PNI is an important independent prognostic factor after ESD in EGC,
but are there any data that low PNI was associated with other causes of death (cardiovascular and
pneumonia)?  The authors should add that description. If authors don't have the data, consider
including a reference that can explain them.
##There is a description of selection bias in the limitation section, but it is recommended to add
it in a little more detail. For example, "This study included only patients who were selected by
physicians, and excluded patients who could not undergo ESD because of severe CCI or poor
ECOG PS. ".
assistant