Reviewer's report
Title:Detection of Drug Effects on Gastric Emptying and Contractility Using a
Wireless Motility Capsule
Version: 1Date:28 July 2013
Reviewer: Stefan Rauch
Reviewer's report:
Minor Essential Revisions
The authors have conducted an interesting study using a novel wireless motility
capsule in order to assess the pharmacological effect on gastric emptying. They
have used two different drugs (morphine, erythromycin) compared with placebo
(saline) to study GET in healthy volunteers. I have only a few comments that
should be addressed:
The authors should elaborate a little bit on the inter- and intraindividual
differences in gastric emptying time in healthy persons found in previous studies.
Although there was a statistical significant difference in GET - in general - it
seems that gastric emptying of the capsules in this study remains physiologically.
Furthermore, it would be helpful to show if there is any variability in GET by
giving the IQR.
All the volunteers have received a standardized meal. Food per se can alter
gastric motility. I would add a few remarks about the influence of food and
nondigestible solids on gastric emptying despite the similar formula meals.
What was the rational for using these drug doses? 150 mg erythromycin seems
to be a subtherapeutic dose compared with the data in the literature.
Typing error:
Page 7, line 11 subjects instead of subjected
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Detection of Drug Effects on Gastric Emptying and Contractility Using a
Wireless Motility Capsule
Version: 1Date:28 July 2013
Reviewer: Stefan Rauch
Reviewer's report:
Minor Essential Revisions
The authors have conducted an interesting study using a novel wireless motility
capsule in order to assess the pharmacological effect on gastric emptying. They
have used two different drugs (morphine, erythromycin) compared with placebo
(saline) to study GET in healthy volunteers. I have only a few comments that
should be addressed:
The authors should elaborate a little bit on the inter- and intraindividual
differences in gastric emptying time in healthy persons found in previous studies.
Although there was a statistical significant difference in GET - in general - it
seems that gastric emptying of the capsules in this study remains physiologically.
Furthermore, it would be helpful to show if there is any variability in GET by
giving the IQR.
All the volunteers have received a standardized meal. Food per se can alter
gastric motility. I would add a few remarks about the influence of food and
nondigestible solids on gastric emptying despite the similar formula meals.
What was the rational for using these drug doses? 150 mg erythromycin seems
to be a subtherapeutic dose compared with the data in the literature.
Typing error:
Page 7, line 11 subjects instead of subjected
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Detection of Drug Effects on Gastric Emptying and Contractility Using a
Wireless Motility Capsule
Version: 1Date:28 July 2013
Reviewer: Stefan Rauch
Reviewer's report:
Minor Essential Revisions
The authors have conducted an interesting study using a novel wireless motility
capsule in order to assess the pharmacological effect on gastric emptying. They
have used two different drugs (morphine, erythromycin) compared with placebo
(saline) to study GET in healthy volunteers. I have only a few comments that
should be addressed:
The authors should elaborate a little bit on the inter- and intraindividual
differences in gastric emptying time in healthy persons found in previous studies.
Although there was a statistical significant difference in GET - in general - it
seems that gastric emptying of the capsules in this study remains physiologically.
Furthermore, it would be helpful to show if there is any variability in GET by
giving the IQR.
All the volunteers have received a standardized meal. Food per se can alter
gastric motility. I would add a few remarks about the influence of food and
nondigestible solids on gastric emptying despite the similar formula meals.
What was the rational for using these drug doses? 150 mg erythromycin seems
to be a subtherapeutic dose compared with the data in the literature.
Typing error:
Page 7, line 11 subjects instead of subjected
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant