Title: Additional chemoradiotherapy for superficial esophageal squamous cell carcinoma after
near-circumferential or full-circumferential noncurative endoscopic submucosal dissection: A
retrospective study
Version: 0 Date: 29 May 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Dear authors, I read with great interest your study about additional
CRT after noncurative ESD for esophageal SCC. I would like to make some comments:
- it would be useful for the readers to add the definition of "noncurative" dissection in the abstract
and the introduction.
- please include in the title also the specification of "Squamous cell carcinoma".
- please specify among the inclusion criteria also the circumferential of near circumferential (2/3)
extension of the cancer. This justifies the exclusion of 8 patients.
- add a study flow chart with the number of patients treated for SCC with ESD, the number of
patients excluded, the number of patients with CURATIVE ESD and the number of patients
who underwent surgery.
- about the previous comment: the main bias of your study is the selection bias, as highlighted in
  the discussion. How many patients were treated with ESD during the study period? how many
with curative dissection? and, the most important information, how many patients were treated
with surgery after noncurative ESD? you must provide complete data (patients characteristics
and outcomes) in order to make your data more useful.
- in conclusion: I would like to suggest to perform a comparative study between ESD+ CRT
and ESD followed by surgery
Title: Additional chemoradiotherapy for superficial esophageal squamous cell carcinoma after
near-circumferential or full-circumferential noncurative endoscopic submucosal dissection: A
retrospective study
Version: 0 Date: 29 May 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Dear authors, I read with great interest your study about additional
CRT after noncurative ESD for esophageal SCC. I would like to make some comments:
- it would be useful for the readers to add the definition of "noncurative" dissection in the abstract
and the introduction.
- please include in the title also the specification of "Squamous cell carcinoma".
- please specify among the inclusion criteria also the circumferential of near circumferential (2/3)
extension of the cancer. This justifies the exclusion of 8 patients.
- add a study flow chart with the number of patients treated for SCC with ESD, the number of
patients excluded, the number of patients with CURATIVE ESD and the number of patients
who underwent surgery.
- about the previous comment: the main bias of your study is the selection bias, as highlighted in
  the discussion. How many patients were treated with ESD during the study period? how many
with curative dissection? and, the most important information, how many patients were treated
with surgery after noncurative ESD? you must provide complete data (patients characteristics
and outcomes) in order to make your data more useful.
- in conclusion: I would like to suggest to perform a comparative study between ESD+ CRT
and ESD followed by surgery
Please review this paper.
user
Title: Additional chemoradiotherapy for superficial esophageal squamous cell carcinoma after
near-circumferential or full-circumferential noncurative endoscopic submucosal dissection: A
retrospective study
Version: 0 Date: 29 May 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Dear authors, I read with great interest your study about additional
CRT after noncurative ESD for esophageal SCC. I would like to make some comments:
- it would be useful for the readers to add the definition of "noncurative" dissection in the abstract
and the introduction.
- please include in the title also the specification of "Squamous cell carcinoma".
- please specify among the inclusion criteria also the circumferential of near circumferential (2/3)
extension of the cancer. This justifies the exclusion of 8 patients.
- add a study flow chart with the number of patients treated for SCC with ESD, the number of
patients excluded, the number of patients with CURATIVE ESD and the number of patients
who underwent surgery.
- about the previous comment: the main bias of your study is the selection bias, as highlighted in
  the discussion. How many patients were treated with ESD during the study period? how many
with curative dissection? and, the most important information, how many patients were treated
with surgery after noncurative ESD? you must provide complete data (patients characteristics
and outcomes) in order to make your data more useful.
- in conclusion: I would like to suggest to perform a comparative study between ESD+ CRT
and ESD followed by surgery
assistant