Title: Investigation of the Mechanism by which miR-223-3p Inhibits Reflux Esophagitis
through Targeting the NLRP3 Inflammasome
Version: 3 Date: 30 Jan 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
The study is well designed and the methodology is robust. However, the manuscript mentions
contradictory findings regarding miR-223-3p expression in reflux esophagitis (higher in some
studies, lower in others). This discrepancy should be discussed in greater depth, possibly
exploring factors such as disease stage, tissue specificity, or methodological differences that
could explain the variation. Second, while the study demonstrates that miR-223-3p targets
NLRP3, the precise molecular mechanisms by which miR-223-3p regulates NLRP3 activation
(e.g., through NF-#B or other pathways) remain unclear. A more detailed discussion of potential
signaling pathways would strengthen the mechanistic insights.
Title: Investigation of the Mechanism by which miR-223-3p Inhibits Reflux Esophagitis
through Targeting the NLRP3 Inflammasome
Version: 3 Date: 30 Jan 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
The study is well designed and the methodology is robust. However, the manuscript mentions
contradictory findings regarding miR-223-3p expression in reflux esophagitis (higher in some
studies, lower in others). This discrepancy should be discussed in greater depth, possibly
exploring factors such as disease stage, tissue specificity, or methodological differences that
could explain the variation. Second, while the study demonstrates that miR-223-3p targets
NLRP3, the precise molecular mechanisms by which miR-223-3p regulates NLRP3 activation
(e.g., through NF-#B or other pathways) remain unclear. A more detailed discussion of potential
signaling pathways would strengthen the mechanistic insights.
Please review this paper.
user
Title: Investigation of the Mechanism by which miR-223-3p Inhibits Reflux Esophagitis
through Targeting the NLRP3 Inflammasome
Version: 3 Date: 30 Jan 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
The study is well designed and the methodology is robust. However, the manuscript mentions
contradictory findings regarding miR-223-3p expression in reflux esophagitis (higher in some
studies, lower in others). This discrepancy should be discussed in greater depth, possibly
exploring factors such as disease stage, tissue specificity, or methodological differences that
could explain the variation. Second, while the study demonstrates that miR-223-3p targets
NLRP3, the precise molecular mechanisms by which miR-223-3p regulates NLRP3 activation
(e.g., through NF-#B or other pathways) remain unclear. A more detailed discussion of potential
signaling pathways would strengthen the mechanistic insights.
assistant