Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 4Date:18 July 2008
Reviewer: Philippe Ducrotte
Reviewer's report:
We have few data about the colonic motor effects of erythromycin. Therefore this
paper is interesting even if it is a retropective study performed in 10 children with
constipation and if it tested a single dose of the drug.
I consider that this paper is suitable to be published in BMC. However, the
presentation of the paper has to be be improved and some methodological
details have to be given.
- was the end of the manometric probe located in the caecum in every child ?
- were the children anaesthetized for the colonoscopy. If the answer if yes, how
long was the interval of time between colonoscopy and manometric recording ?
Indeed, the AUC seems very low.
- Is the definition of the gastrocolonic response an "home-made" definition ?
- what is a meal appropriate for the age ?
- the tracings were only analyzed quantitatively. Did erythromycin induce specific
motor patterns (custers of contractions...)
- the last paragraph of the discussion is useless.
Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 4Date:18 July 2008
Reviewer: Philippe Ducrotte
Reviewer's report:
We have few data about the colonic motor effects of erythromycin. Therefore this
paper is interesting even if it is a retropective study performed in 10 children with
constipation and if it tested a single dose of the drug.
I consider that this paper is suitable to be published in BMC. However, the
presentation of the paper has to be be improved and some methodological
details have to be given.
- was the end of the manometric probe located in the caecum in every child ?
- were the children anaesthetized for the colonoscopy. If the answer if yes, how
long was the interval of time between colonoscopy and manometric recording ?
Indeed, the AUC seems very low.
- Is the definition of the gastrocolonic response an "home-made" definition ?
- what is a meal appropriate for the age ?
- the tracings were only analyzed quantitatively. Did erythromycin induce specific
motor patterns (custers of contractions...)
- the last paragraph of the discussion is useless.
Please review this paper.
user
Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 4Date:18 July 2008
Reviewer: Philippe Ducrotte
Reviewer's report:
We have few data about the colonic motor effects of erythromycin. Therefore this
paper is interesting even if it is a retropective study performed in 10 children with
constipation and if it tested a single dose of the drug.
I consider that this paper is suitable to be published in BMC. However, the
presentation of the paper has to be be improved and some methodological
details have to be given.
- was the end of the manometric probe located in the caecum in every child ?
- were the children anaesthetized for the colonoscopy. If the answer if yes, how
long was the interval of time between colonoscopy and manometric recording ?
Indeed, the AUC seems very low.
- Is the definition of the gastrocolonic response an "home-made" definition ?
- what is a meal appropriate for the age ?
- the tracings were only analyzed quantitatively. Did erythromycin induce specific
motor patterns (custers of contractions...)
- the last paragraph of the discussion is useless.
assistant