Reviewer's report
Title:A case of rectal tumor in which the shape altered with regression in short
period
Version: 1Date:26 June 2013
Reviewer: Charles LeVea
Reviewer's report:
The paper describes a 10 mm well differentiated adenocarcinoma that
"spontaneously" regressed after biopsy to a 1 mm lesion. An endoscopic
submucosal resection with a ligation device was performed a month after
diagnosis to resect the tumor from an area that the endoscopist had difficulty
identifying as tumor. This may have been from the same area as the initial
biopsy; however, tattoo ink was not used at the time of initial biopsy to mark the
site of the tumor. From the submitted photomicrographs, this resection specimen
contained submucosal fibrosis, intramucosal hemorrhage, and a single gland
with high grade glandular dysplasia. I could not identify residual
adeonocarcinoma in the photos in the submitted figure. Additionally, the initial
biopsy that carried a diagnosis of a well differentiated adenocarcinoma was not
submitted as a figure. Therefore, this case report is based on an uncomfirmed
diagnosis of adenocarcinoma. Without an ability to confirm that an
adenocarcinoma was present, this case report should not be accepted for
publication. Please see Major Compulsory Revisions below.
Major Compulsory Revisions
1. Figure of the initial biopsy specimen clearly showing an adenocarcinoma
2. Diagnosis for Figure 6 - high grade glandular dysplasia - not invasive
adenocarcinoma or show picture proving invasion
Minor Essential Revision
"further" is misspelled page 5 line 3
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interests to declare.
Reviewer's report
Title:A case of rectal tumor in which the shape altered with regression in short
period
Version: 1Date:26 June 2013
Reviewer: Charles LeVea
Reviewer's report:
The paper describes a 10 mm well differentiated adenocarcinoma that
"spontaneously" regressed after biopsy to a 1 mm lesion. An endoscopic
submucosal resection with a ligation device was performed a month after
diagnosis to resect the tumor from an area that the endoscopist had difficulty
identifying as tumor. This may have been from the same area as the initial
biopsy; however, tattoo ink was not used at the time of initial biopsy to mark the
site of the tumor. From the submitted photomicrographs, this resection specimen
contained submucosal fibrosis, intramucosal hemorrhage, and a single gland
with high grade glandular dysplasia. I could not identify residual
adeonocarcinoma in the photos in the submitted figure. Additionally, the initial
biopsy that carried a diagnosis of a well differentiated adenocarcinoma was not
submitted as a figure. Therefore, this case report is based on an uncomfirmed
diagnosis of adenocarcinoma. Without an ability to confirm that an
adenocarcinoma was present, this case report should not be accepted for
publication. Please see Major Compulsory Revisions below.
Major Compulsory Revisions
1. Figure of the initial biopsy specimen clearly showing an adenocarcinoma
2. Diagnosis for Figure 6 - high grade glandular dysplasia - not invasive
adenocarcinoma or show picture proving invasion
Minor Essential Revision
"further" is misspelled page 5 line 3
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interests to declare.
Please review this paper.
user
Reviewer's report
Title:A case of rectal tumor in which the shape altered with regression in short
period
Version: 1Date:26 June 2013
Reviewer: Charles LeVea
Reviewer's report:
The paper describes a 10 mm well differentiated adenocarcinoma that
"spontaneously" regressed after biopsy to a 1 mm lesion. An endoscopic
submucosal resection with a ligation device was performed a month after
diagnosis to resect the tumor from an area that the endoscopist had difficulty
identifying as tumor. This may have been from the same area as the initial
biopsy; however, tattoo ink was not used at the time of initial biopsy to mark the
site of the tumor. From the submitted photomicrographs, this resection specimen
contained submucosal fibrosis, intramucosal hemorrhage, and a single gland
with high grade glandular dysplasia. I could not identify residual
adeonocarcinoma in the photos in the submitted figure. Additionally, the initial
biopsy that carried a diagnosis of a well differentiated adenocarcinoma was not
submitted as a figure. Therefore, this case report is based on an uncomfirmed
diagnosis of adenocarcinoma. Without an ability to confirm that an
adenocarcinoma was present, this case report should not be accepted for
publication. Please see Major Compulsory Revisions below.
Major Compulsory Revisions
1. Figure of the initial biopsy specimen clearly showing an adenocarcinoma
2. Diagnosis for Figure 6 - high grade glandular dysplasia - not invasive
adenocarcinoma or show picture proving invasion
Minor Essential Revision
"further" is misspelled page 5 line 3
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interests to declare.
assistant