Title: Elevated Average Maximum Intrabolus Pressure on High-Resolution Manometry is
Associated with Esophageal Dysmotility and Delayed Esophageal Emptying on Timed Barium
Esophagram
Version: 2 Date: 28 Dec 2021
Reviewer's report:
The report demonstrate that an elevated AM-IBP is associated with abnormal TBE findings
of esophageal tablet retention and/or bolus stasis. The finding is novel and supported with
detailed case studies and statistical results. The only comment for the revision is on the method.
Specifically, with the advance of HRM, the IBP could be visualized as moving region along
with the peristaltic wave. Hence, how is the IBP region defined? The second question is about
the time window to compute AM-IBP. A normal bolus transit includes several phases, so does
this time window include all phases or only phases related bolus emptying (i.e after transition
zone)?  With the advance of impedance manometry, impedance could more naturally identify
and track the intra-bolus region. Can the author add comment on this? Thanks.
Title: Elevated Average Maximum Intrabolus Pressure on High-Resolution Manometry is
Associated with Esophageal Dysmotility and Delayed Esophageal Emptying on Timed Barium
Esophagram
Version: 2 Date: 28 Dec 2021
Reviewer's report:
The report demonstrate that an elevated AM-IBP is associated with abnormal TBE findings
of esophageal tablet retention and/or bolus stasis. The finding is novel and supported with
detailed case studies and statistical results. The only comment for the revision is on the method.
Specifically, with the advance of HRM, the IBP could be visualized as moving region along
with the peristaltic wave. Hence, how is the IBP region defined? The second question is about
the time window to compute AM-IBP. A normal bolus transit includes several phases, so does
this time window include all phases or only phases related bolus emptying (i.e after transition
zone)?  With the advance of impedance manometry, impedance could more naturally identify
and track the intra-bolus region. Can the author add comment on this? Thanks.
Please review this paper.
user
Title: Elevated Average Maximum Intrabolus Pressure on High-Resolution Manometry is
Associated with Esophageal Dysmotility and Delayed Esophageal Emptying on Timed Barium
Esophagram
Version: 2 Date: 28 Dec 2021
Reviewer's report:
The report demonstrate that an elevated AM-IBP is associated with abnormal TBE findings
of esophageal tablet retention and/or bolus stasis. The finding is novel and supported with
detailed case studies and statistical results. The only comment for the revision is on the method.
Specifically, with the advance of HRM, the IBP could be visualized as moving region along
with the peristaltic wave. Hence, how is the IBP region defined? The second question is about
the time window to compute AM-IBP. A normal bolus transit includes several phases, so does
this time window include all phases or only phases related bolus emptying (i.e after transition
zone)?  With the advance of impedance manometry, impedance could more naturally identify
and track the intra-bolus region. Can the author add comment on this? Thanks.
assistant