Reviewer's report
Title:Outcome of liver transplantation with Histidine-Tryptophan-Ketoglutarate vs.
University of Wisconsin preservation solution: A retrospective observational
double-center trial
Version:2Date:9 June 2014
Reviewer: Brian Lam
Reviewer's report:
Overall, this is a very interesting and well-done retrospective analysis. The
author's make the clinical and economic relevance of the issue clear.
Major Compulsory Revisions: None
Minor Essential Revisions
1. (pg 10), under Pediatric and living donor transplant: The meaning of this
sentence is unclear: "There was no association of one of the investigated PS with
biliary complications..." This sentence on pg 11 regarding prolonged CIT is
clearer: "there was no statistically significant difference between the rate of biliary
complications in the two PS cohorts (p=0.097)."
2. (pg 14). "HTK is clinically easier to handle, because it is sold in ready-to-use
units while UW must be mixed with additives prior to use. although this might not
be done anymore in some centers without deteriorating outcome."
## if the authors intend to keep the last clause ("although this might ... outcome"),
further details or at least a reference should be provided.
## "prior to use" should be followed by a comma.
Discretionary Revisions:
1. Under Patients and Methods (pg 5), 1376 males + 1177 females = a total
cohort of 2553. Was gender not specified for the remaining subject?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Outcome of liver transplantation with Histidine-Tryptophan-Ketoglutarate vs.
University of Wisconsin preservation solution: A retrospective observational
double-center trial
Version:2Date:9 June 2014
Reviewer: Brian Lam
Reviewer's report:
Overall, this is a very interesting and well-done retrospective analysis. The
author's make the clinical and economic relevance of the issue clear.
Major Compulsory Revisions: None
Minor Essential Revisions
1. (pg 10), under Pediatric and living donor transplant: The meaning of this
sentence is unclear: "There was no association of one of the investigated PS with
biliary complications..." This sentence on pg 11 regarding prolonged CIT is
clearer: "there was no statistically significant difference between the rate of biliary
complications in the two PS cohorts (p=0.097)."
2. (pg 14). "HTK is clinically easier to handle, because it is sold in ready-to-use
units while UW must be mixed with additives prior to use. although this might not
be done anymore in some centers without deteriorating outcome."
## if the authors intend to keep the last clause ("although this might ... outcome"),
further details or at least a reference should be provided.
## "prior to use" should be followed by a comma.
Discretionary Revisions:
1. Under Patients and Methods (pg 5), 1376 males + 1177 females = a total
cohort of 2553. Was gender not specified for the remaining subject?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Outcome of liver transplantation with Histidine-Tryptophan-Ketoglutarate vs.
University of Wisconsin preservation solution: A retrospective observational
double-center trial
Version:2Date:9 June 2014
Reviewer: Brian Lam
Reviewer's report:
Overall, this is a very interesting and well-done retrospective analysis. The
author's make the clinical and economic relevance of the issue clear.
Major Compulsory Revisions: None
Minor Essential Revisions
1. (pg 10), under Pediatric and living donor transplant: The meaning of this
sentence is unclear: "There was no association of one of the investigated PS with
biliary complications..." This sentence on pg 11 regarding prolonged CIT is
clearer: "there was no statistically significant difference between the rate of biliary
complications in the two PS cohorts (p=0.097)."
2. (pg 14). "HTK is clinically easier to handle, because it is sold in ready-to-use
units while UW must be mixed with additives prior to use. although this might not
be done anymore in some centers without deteriorating outcome."
## if the authors intend to keep the last clause ("although this might ... outcome"),
further details or at least a reference should be provided.
## "prior to use" should be followed by a comma.
Discretionary Revisions:
1. Under Patients and Methods (pg 5), 1376 males + 1177 females = a total
cohort of 2553. Was gender not specified for the remaining subject?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant