Title: Efficacy and safety of subanesthetic doses of esketamine combined with propofol in
painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial
Version: 2 Date: 10 Jun 2022
Reviewer's report:
1. If the blindless anesthesiologist who administered the drugs was the one who performed
MMSE, how can blindness of the study be ensured?
2. "Phenylephrine 0.1 mg was injected when BP was below 30% of the baseline level" - what
is the rationale for this standard of care?
3. How did you define the procedure time? "procedure time (from the insertion of the gastroscope
to the withdrawal of the colonoscope), " sounds like 2 different procedures.
4. "A total of 260 patients undergoing painless gastrointestinal endoscopy " - how many of them
underwent EGD and how many of them underwent colonoscopy?
5. "No arrhythmia, nausea and vomiting, apnea (Table 4), hallucinations, delirium, depression,
and other psychosocial abnormalities were observed". Not sure if psychosocial abnormalities
the correct term here.
6. Some grammatical corrections (eg: indices instead of indexes, removing a from "Esketamine
is a dextrorotatory structure of ketamine with a twice as great anesthetic effect ... ") need to be
done. Suggest using some grammar correction software for ease.
Title: Efficacy and safety of subanesthetic doses of esketamine combined with propofol in
painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial
Version: 2 Date: 10 Jun 2022
Reviewer's report:
1. If the blindless anesthesiologist who administered the drugs was the one who performed
MMSE, how can blindness of the study be ensured?
2. "Phenylephrine 0.1 mg was injected when BP was below 30% of the baseline level" - what
is the rationale for this standard of care?
3. How did you define the procedure time? "procedure time (from the insertion of the gastroscope
to the withdrawal of the colonoscope), " sounds like 2 different procedures.
4. "A total of 260 patients undergoing painless gastrointestinal endoscopy " - how many of them
underwent EGD and how many of them underwent colonoscopy?
5. "No arrhythmia, nausea and vomiting, apnea (Table 4), hallucinations, delirium, depression,
and other psychosocial abnormalities were observed". Not sure if psychosocial abnormalities
the correct term here.
6. Some grammatical corrections (eg: indices instead of indexes, removing a from "Esketamine
is a dextrorotatory structure of ketamine with a twice as great anesthetic effect ... ") need to be
done. Suggest using some grammar correction software for ease.
Please review this paper.
user
Title: Efficacy and safety of subanesthetic doses of esketamine combined with propofol in
painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial
Version: 2 Date: 10 Jun 2022
Reviewer's report:
1. If the blindless anesthesiologist who administered the drugs was the one who performed
MMSE, how can blindness of the study be ensured?
2. "Phenylephrine 0.1 mg was injected when BP was below 30% of the baseline level" - what
is the rationale for this standard of care?
3. How did you define the procedure time? "procedure time (from the insertion of the gastroscope
to the withdrawal of the colonoscope), " sounds like 2 different procedures.
4. "A total of 260 patients undergoing painless gastrointestinal endoscopy " - how many of them
underwent EGD and how many of them underwent colonoscopy?
5. "No arrhythmia, nausea and vomiting, apnea (Table 4), hallucinations, delirium, depression,
and other psychosocial abnormalities were observed". Not sure if psychosocial abnormalities
the correct term here.
6. Some grammatical corrections (eg: indices instead of indexes, removing a from "Esketamine
is a dextrorotatory structure of ketamine with a twice as great anesthetic effect ... ") need to be
done. Suggest using some grammar correction software for ease.
assistant