Reviewer's report
Title:Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel
intraepithelial lymphocytosis: case report and literature review
Version: 2Date:7 July 2011
Reviewer: Massimo Montalto
Reviewer's report:
The work by Shrinivas Bishu et al. describes a 28 yrs female with autoimmune
enteropathy and autoimmune hepatitis in which steroidal therapy ameliorated
abdominal clinical picture but was not efficacious on liver function.
The paper points on an interesting topic but some doubts have to be underlined.
Major Compulsory Revisions
- the diagnostic criteria to make a correct diagnosis of autoimmune enteropathy
provide a “no response to exclusion diets”: there is no specific references about
this;
- an endoscopic examination of the colon is mandatory to complete an adequate
differential diagnosis;
- as also Authors say, the diagnosis of autoimmune hepatitis is strengthless;
moreover, steroidal treatment did not ameliorate the liver function; in the absence
of autoimmune hepatitis, in this patient the diagnosis of autoimmune enteropathy
cannot be made;
- have the Authors evaluate others atypical autoantibodies such as ASGPR,
liver-pancreas antigens, and liver cytosol?
Minor Essential Revisions
HLA genotypes evaluation (negativity for DQ2/DQ8) should be reported in case
report description and not only in discussion (I think that this finding is more
significant than anti-transglutaminase antibody negativity for exclusion of celiac
disease.)
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel
intraepithelial lymphocytosis: case report and literature review
Version: 2Date:7 July 2011
Reviewer: Massimo Montalto
Reviewer's report:
The work by Shrinivas Bishu et al. describes a 28 yrs female with autoimmune
enteropathy and autoimmune hepatitis in which steroidal therapy ameliorated
abdominal clinical picture but was not efficacious on liver function.
The paper points on an interesting topic but some doubts have to be underlined.
Major Compulsory Revisions
- the diagnostic criteria to make a correct diagnosis of autoimmune enteropathy
provide a “no response to exclusion diets”: there is no specific references about
this;
- an endoscopic examination of the colon is mandatory to complete an adequate
differential diagnosis;
- as also Authors say, the diagnosis of autoimmune hepatitis is strengthless;
moreover, steroidal treatment did not ameliorate the liver function; in the absence
of autoimmune hepatitis, in this patient the diagnosis of autoimmune enteropathy
cannot be made;
- have the Authors evaluate others atypical autoantibodies such as ASGPR,
liver-pancreas antigens, and liver cytosol?
Minor Essential Revisions
HLA genotypes evaluation (negativity for DQ2/DQ8) should be reported in case
report description and not only in discussion (I think that this finding is more
significant than anti-transglutaminase antibody negativity for exclusion of celiac
disease.)
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Autoimmune enteropathy with a CD8+ CD7- T-cell small bowel
intraepithelial lymphocytosis: case report and literature review
Version: 2Date:7 July 2011
Reviewer: Massimo Montalto
Reviewer's report:
The work by Shrinivas Bishu et al. describes a 28 yrs female with autoimmune
enteropathy and autoimmune hepatitis in which steroidal therapy ameliorated
abdominal clinical picture but was not efficacious on liver function.
The paper points on an interesting topic but some doubts have to be underlined.
Major Compulsory Revisions
- the diagnostic criteria to make a correct diagnosis of autoimmune enteropathy
provide a “no response to exclusion diets”: there is no specific references about
this;
- an endoscopic examination of the colon is mandatory to complete an adequate
differential diagnosis;
- as also Authors say, the diagnosis of autoimmune hepatitis is strengthless;
moreover, steroidal treatment did not ameliorate the liver function; in the absence
of autoimmune hepatitis, in this patient the diagnosis of autoimmune enteropathy
cannot be made;
- have the Authors evaluate others atypical autoantibodies such as ASGPR,
liver-pancreas antigens, and liver cytosol?
Minor Essential Revisions
HLA genotypes evaluation (negativity for DQ2/DQ8) should be reported in case
report description and not only in discussion (I think that this finding is more
significant than anti-transglutaminase antibody negativity for exclusion of celiac
disease.)
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant