Reviewer's report
Title:Lack of association between peroxisome proliferator-activated receptors
alpha and gamma2 polymorphisms and progressive liver damage in patients with
non-alcoholic fatty liver disease: a case control study
Version: 1Date:30 May 2010
Reviewer: Katsutoshi Tokushige
Reviewer's report:
This paper is interesting, suggesting that the PPAR alpha 162 Val allele was
associated with insulin resistance, but not with liver damage in NAFLD. However,
there are several problems.
Major
1.Some of NAFLD patients had diabetes mellitus (DM). If these patients receive
drug therapy against DM, HOMA-R value is influenced by drug. Please show the
therapy in these patients.
2.In control subjects, fasting insulin and glucose were measured. How is the
relationship between HOMA-R and PPAR alpha SNP in controls?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Lack of association between peroxisome proliferator-activated receptors
alpha and gamma2 polymorphisms and progressive liver damage in patients with
non-alcoholic fatty liver disease: a case control study
Version: 1Date:30 May 2010
Reviewer: Katsutoshi Tokushige
Reviewer's report:
This paper is interesting, suggesting that the PPAR alpha 162 Val allele was
associated with insulin resistance, but not with liver damage in NAFLD. However,
there are several problems.
Major
1.Some of NAFLD patients had diabetes mellitus (DM). If these patients receive
drug therapy against DM, HOMA-R value is influenced by drug. Please show the
therapy in these patients.
2.In control subjects, fasting insulin and glucose were measured. How is the
relationship between HOMA-R and PPAR alpha SNP in controls?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Lack of association between peroxisome proliferator-activated receptors
alpha and gamma2 polymorphisms and progressive liver damage in patients with
non-alcoholic fatty liver disease: a case control study
Version: 1Date:30 May 2010
Reviewer: Katsutoshi Tokushige
Reviewer's report:
This paper is interesting, suggesting that the PPAR alpha 162 Val allele was
associated with insulin resistance, but not with liver damage in NAFLD. However,
there are several problems.
Major
1.Some of NAFLD patients had diabetes mellitus (DM). If these patients receive
drug therapy against DM, HOMA-R value is influenced by drug. Please show the
therapy in these patients.
2.In control subjects, fasting insulin and glucose were measured. How is the
relationship between HOMA-R and PPAR alpha SNP in controls?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant