Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 3 Date: 12 Apr 2021
Reviewer's report:
My comments regarding this work are as follows.
1. How does the current study suggested that ICA-AKI can detect renal dysfunction in AVB
patients earlier?
According to the conventional diagnostic criteria of AKI, 97 (17.8%) patients developed AKI
within 42 days. According to the ICA diagnostic criteria of AKI, AKI was present in 128 (83.7%)
patients at admission, whereas 7 (4.6%) had AKI beyond 5 days of hospitalization. The number
of AKI differed by 38 cases for both diagnostic criteria. What are the characteristics of these
patients? For example, which stage of ICA-AKI are these patients belong?
The authors simply compared the number of people diagnosed and the mortality rate between
the two diagnostic criteria. Is the number of newly diagnosed persons in ICA standard, which
missed by conventional standard, due to their mild of AKI?
2. The method of calculation of mortality in patients with AKI seems to be different for the two
diagnostic criteria. In conventional criteria, mortality is calculated from the number of patients
(41.2% (40/97)). In the ICA criteria, Mortality was calculated from the number of AKI events
(28.1% (43/153)).
3. Can the author provide relevant data regarding the diabetes? In the reply of authors, “Although
our paper is retrospective study, diabetes did not affect mortality in patients with variceal
bleeding.”
I don't think this problem can be solved by a simple description. Data should be provided to
explain this.
Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 3 Date: 12 Apr 2021
Reviewer's report:
My comments regarding this work are as follows.
1. How does the current study suggested that ICA-AKI can detect renal dysfunction in AVB
patients earlier?
According to the conventional diagnostic criteria of AKI, 97 (17.8%) patients developed AKI
within 42 days. According to the ICA diagnostic criteria of AKI, AKI was present in 128 (83.7%)
patients at admission, whereas 7 (4.6%) had AKI beyond 5 days of hospitalization. The number
of AKI differed by 38 cases for both diagnostic criteria. What are the characteristics of these
patients? For example, which stage of ICA-AKI are these patients belong?
The authors simply compared the number of people diagnosed and the mortality rate between
the two diagnostic criteria. Is the number of newly diagnosed persons in ICA standard, which
missed by conventional standard, due to their mild of AKI?
2. The method of calculation of mortality in patients with AKI seems to be different for the two
diagnostic criteria. In conventional criteria, mortality is calculated from the number of patients
(41.2% (40/97)). In the ICA criteria, Mortality was calculated from the number of AKI events
(28.1% (43/153)).
3. Can the author provide relevant data regarding the diabetes? In the reply of authors, “Although
our paper is retrospective study, diabetes did not affect mortality in patients with variceal
bleeding.”
I don't think this problem can be solved by a simple description. Data should be provided to
explain this.
Please review this paper.
user
Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 3 Date: 12 Apr 2021
Reviewer's report:
My comments regarding this work are as follows.
1. How does the current study suggested that ICA-AKI can detect renal dysfunction in AVB
patients earlier?
According to the conventional diagnostic criteria of AKI, 97 (17.8%) patients developed AKI
within 42 days. According to the ICA diagnostic criteria of AKI, AKI was present in 128 (83.7%)
patients at admission, whereas 7 (4.6%) had AKI beyond 5 days of hospitalization. The number
of AKI differed by 38 cases for both diagnostic criteria. What are the characteristics of these
patients? For example, which stage of ICA-AKI are these patients belong?
The authors simply compared the number of people diagnosed and the mortality rate between
the two diagnostic criteria. Is the number of newly diagnosed persons in ICA standard, which
missed by conventional standard, due to their mild of AKI?
2. The method of calculation of mortality in patients with AKI seems to be different for the two
diagnostic criteria. In conventional criteria, mortality is calculated from the number of patients
(41.2% (40/97)). In the ICA criteria, Mortality was calculated from the number of AKI events
(28.1% (43/153)).
3. Can the author provide relevant data regarding the diabetes? In the reply of authors, “Although
our paper is retrospective study, diabetes did not affect mortality in patients with variceal
bleeding.”
I don't think this problem can be solved by a simple description. Data should be provided to
explain this.
assistant