Reviewer's report
Title:Transcript levels of different cytokines and chemokines correlate with
clinical and endoscopic activity in ulcerative colitis
Version: 3Date:7 November 2008
Reviewer: Stig Larsen
Reviewer's report:
It is much better but they can not conclude as they do. They conclude that the
method is "Valid and reliable".
In order to claim Validity and reliability of a method they need to give sensitivity
and spesifisity of the method. This might be problematic in this case. However, I
will recommand them to express CAI and EAI as a linear function of the set of
independant variables (CXCL2,8,10 and calgranulin B). Additionally, by reporting
R2 they will give how much of the variation of CAI and EAI are expressed by the
set of independant variables. Then it might be they can give a conclusion like the
one they have in the manuscript.
Reviewer's report
Title:Transcript levels of different cytokines and chemokines correlate with
clinical and endoscopic activity in ulcerative colitis
Version: 3Date:7 November 2008
Reviewer: Stig Larsen
Reviewer's report:
It is much better but they can not conclude as they do. They conclude that the
method is "Valid and reliable".
In order to claim Validity and reliability of a method they need to give sensitivity
and spesifisity of the method. This might be problematic in this case. However, I
will recommand them to express CAI and EAI as a linear function of the set of
independant variables (CXCL2,8,10 and calgranulin B). Additionally, by reporting
R2 they will give how much of the variation of CAI and EAI are expressed by the
set of independant variables. Then it might be they can give a conclusion like the
one they have in the manuscript.
Please review this paper.
user
Reviewer's report
Title:Transcript levels of different cytokines and chemokines correlate with
clinical and endoscopic activity in ulcerative colitis
Version: 3Date:7 November 2008
Reviewer: Stig Larsen
Reviewer's report:
It is much better but they can not conclude as they do. They conclude that the
method is "Valid and reliable".
In order to claim Validity and reliability of a method they need to give sensitivity
and spesifisity of the method. This might be problematic in this case. However, I
will recommand them to express CAI and EAI as a linear function of the set of
independant variables (CXCL2,8,10 and calgranulin B). Additionally, by reporting
R2 they will give how much of the variation of CAI and EAI are expressed by the
set of independant variables. Then it might be they can give a conclusion like the
one they have in the manuscript.
assistant