Title: Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study
using a national inpatient database
Version: 2 Date: 29 Mar 2023
Reviewer's report:
Ref: Submission ID 92a7c6c0-2fe8-4e6b-9e36-ed2d79d8b1f5
"Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study using
a national inpatient database".
Tateishi R et al.
Authors retrospectively examined the treatment and outcome of patients with hepatorenal
syndrome (HRS) by Japanese Diagnosis Procedure Combination database in 2010-2019.
Authors confirmed that HRS was high mortality in Japan. Only 7 of 1640 patients with HRS
were underwent liver transplantation. Albumin was most frequently administered to HRS.
It was meaningful to elucidate the recent treatment and outcome of HRS in real-world.
Although more than 1000 patients were examined, there was a few findings beyond the previous
reports about HRS.
If possible, authors should address the below points. How about the prevalence of HRS type I
and II, the incidence of spontaneous bacterial peritonitis, and the direct cause of death in the
present patients?
Authors stated that dopamine was more frequently used as a vasoconstrictor in clinical practice
although noradrenaline was recommended in guideline. Do authors think that noradrenaline
is suitable for HRS, compared to dopamine? Were there any differences in outcome between
noradrenaline group and dopamine group?
Minor; How many patients were two or more vasoconstrictors administered to?
Title: Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study
using a national inpatient database
Version: 2 Date: 29 Mar 2023
Reviewer's report:
Ref: Submission ID 92a7c6c0-2fe8-4e6b-9e36-ed2d79d8b1f5
"Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study using
a national inpatient database".
Tateishi R et al.
Authors retrospectively examined the treatment and outcome of patients with hepatorenal
syndrome (HRS) by Japanese Diagnosis Procedure Combination database in 2010-2019.
Authors confirmed that HRS was high mortality in Japan. Only 7 of 1640 patients with HRS
were underwent liver transplantation. Albumin was most frequently administered to HRS.
It was meaningful to elucidate the recent treatment and outcome of HRS in real-world.
Although more than 1000 patients were examined, there was a few findings beyond the previous
reports about HRS.
If possible, authors should address the below points. How about the prevalence of HRS type I
and II, the incidence of spontaneous bacterial peritonitis, and the direct cause of death in the
present patients?
Authors stated that dopamine was more frequently used as a vasoconstrictor in clinical practice
although noradrenaline was recommended in guideline. Do authors think that noradrenaline
is suitable for HRS, compared to dopamine? Were there any differences in outcome between
noradrenaline group and dopamine group?
Minor; How many patients were two or more vasoconstrictors administered to?
Please review this paper.
user
Title: Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study
using a national inpatient database
Version: 2 Date: 29 Mar 2023
Reviewer's report:
Ref: Submission ID 92a7c6c0-2fe8-4e6b-9e36-ed2d79d8b1f5
"Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study using
a national inpatient database".
Tateishi R et al.
Authors retrospectively examined the treatment and outcome of patients with hepatorenal
syndrome (HRS) by Japanese Diagnosis Procedure Combination database in 2010-2019.
Authors confirmed that HRS was high mortality in Japan. Only 7 of 1640 patients with HRS
were underwent liver transplantation. Albumin was most frequently administered to HRS.
It was meaningful to elucidate the recent treatment and outcome of HRS in real-world.
Although more than 1000 patients were examined, there was a few findings beyond the previous
reports about HRS.
If possible, authors should address the below points. How about the prevalence of HRS type I
and II, the incidence of spontaneous bacterial peritonitis, and the direct cause of death in the
present patients?
Authors stated that dopamine was more frequently used as a vasoconstrictor in clinical practice
although noradrenaline was recommended in guideline. Do authors think that noradrenaline
is suitable for HRS, compared to dopamine? Were there any differences in outcome between
noradrenaline group and dopamine group?
Minor; How many patients were two or more vasoconstrictors administered to?
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