Title: Randomised clinical trial: 3-year interim analysis results of the VISION trial to
evaluate the long-term safety of vonoprazan as maintenance treatment in patients with erosive
oesophagitis
Version: 3 Date: 14 Mar 2023
Reviewer:  Kenta Watanabe
Reviewer's report:
This is a well designed study that provides convincing evidence of the long-term safety arising
in the 3-year usage of vonoprazan using both histopathological assessment and endoscopic
findings.
The authors interpret their data very well and the findings are very convincing.
In particular, no neoplastic/dysplastic alteration of epithelial cells and no occurrence or increase
in intestinal metaplasia is very interesting and noteworthy.
Title: Randomised clinical trial: 3-year interim analysis results of the VISION trial to
evaluate the long-term safety of vonoprazan as maintenance treatment in patients with erosive
oesophagitis
Version: 3 Date: 14 Mar 2023
Reviewer:  Kenta Watanabe
Reviewer's report:
This is a well designed study that provides convincing evidence of the long-term safety arising
in the 3-year usage of vonoprazan using both histopathological assessment and endoscopic
findings.
The authors interpret their data very well and the findings are very convincing.
In particular, no neoplastic/dysplastic alteration of epithelial cells and no occurrence or increase
in intestinal metaplasia is very interesting and noteworthy.
Please review this paper.
user
Title: Randomised clinical trial: 3-year interim analysis results of the VISION trial to
evaluate the long-term safety of vonoprazan as maintenance treatment in patients with erosive
oesophagitis
Version: 3 Date: 14 Mar 2023
Reviewer:  Kenta Watanabe
Reviewer's report:
This is a well designed study that provides convincing evidence of the long-term safety arising
in the 3-year usage of vonoprazan using both histopathological assessment and endoscopic
findings.
The authors interpret their data very well and the findings are very convincing.
In particular, no neoplastic/dysplastic alteration of epithelial cells and no occurrence or increase
in intestinal metaplasia is very interesting and noteworthy.
assistant