Title: Development and validation of prognostic nomograms for early-onset colon cancer in
different tumor locations: a population-based study
Version: 2 Date: 04 Aug 2023
Reviewer:  Giorgio Lisi
Reviewer's report:
Dear Authors,
I appreciated what you wrote. The prevalence of early-onset colon cancer (EOCC) among
individuals below the age of 50 has shown a marked upward trend in recent years. This theme
deserves more attention from everyone: surgeons, oncologists, and biologists.
It's a well design study, good statistical analysis.
Concerning the radiotherapy, you assumed that the more radiotherapy patients undergone the
more poor outcome they have. Several studies have shown the benefits of radiotherapy, maybe
those patients have advanced colon cancer compared to patients that do not undergo RT and it
could justified the poor outcome. Please explain in the text, cite and comment more studies.
You should discuss: - different type of surgery during those years - different chemotherapy. All
these topics are needed to create prognostic nomograms.
Kindly Regards
Title: Development and validation of prognostic nomograms for early-onset colon cancer in
different tumor locations: a population-based study
Version: 2 Date: 04 Aug 2023
Reviewer:  Giorgio Lisi
Reviewer's report:
Dear Authors,
I appreciated what you wrote. The prevalence of early-onset colon cancer (EOCC) among
individuals below the age of 50 has shown a marked upward trend in recent years. This theme
deserves more attention from everyone: surgeons, oncologists, and biologists.
It's a well design study, good statistical analysis.
Concerning the radiotherapy, you assumed that the more radiotherapy patients undergone the
more poor outcome they have. Several studies have shown the benefits of radiotherapy, maybe
those patients have advanced colon cancer compared to patients that do not undergo RT and it
could justified the poor outcome. Please explain in the text, cite and comment more studies.
You should discuss: - different type of surgery during those years - different chemotherapy. All
these topics are needed to create prognostic nomograms.
Kindly Regards
Please review this paper.
user
Title: Development and validation of prognostic nomograms for early-onset colon cancer in
different tumor locations: a population-based study
Version: 2 Date: 04 Aug 2023
Reviewer:  Giorgio Lisi
Reviewer's report:
Dear Authors,
I appreciated what you wrote. The prevalence of early-onset colon cancer (EOCC) among
individuals below the age of 50 has shown a marked upward trend in recent years. This theme
deserves more attention from everyone: surgeons, oncologists, and biologists.
It's a well design study, good statistical analysis.
Concerning the radiotherapy, you assumed that the more radiotherapy patients undergone the
more poor outcome they have. Several studies have shown the benefits of radiotherapy, maybe
those patients have advanced colon cancer compared to patients that do not undergo RT and it
could justified the poor outcome. Please explain in the text, cite and comment more studies.
You should discuss: - different type of surgery during those years - different chemotherapy. All
these topics are needed to create prognostic nomograms.
Kindly Regards
assistant