Reviewer's report
Title:Multi-susceptibility genes associated with esophageal squamous cell
cancer risk and their potential use to identify subjects at high risk
Version: 1Date:21 February 2011
Reviewer: YIH-GANG G GOAN
Reviewer's report:
This manuscript presented an interesting but not novel results regarding the
association between genetic polymorphism and esophageal neoplasm.
According to the results of this manuscript, there are several questions needed to
be clarified.
Major Compulsory Revisions
1. The patient numbers of each group with esophageal lesion as well as normal
control were silmilar in this study. How can the authors select patient
prospectively and get equally distributed population groups? Are there inclusion
and exclusion criteria for patient selection?
2. In this study, the results revealed the genotype of ALDH significantly
associatee with the development of esophageal cancer. However, risk factors for
esophageal squamous cell carcinoma are varied geographically. Cigarette
smoking, alcohol consumption, culture of life and condition of foods are
well-known risk factors for esophageal cancers. Did the authors analyze the
interaction effect of alcohol consumption on the relationship between genotype of
ALDH and the stages of esophageal mucosal transformation?
3. How many patients with ALDH2*2 were none alcohol consumption and got
esophageal cancer? How many patients with ALDH 1*1 were heavy drinkers and
got esophageal cancers?
4. Socio-economic status might correlate with the incidence of esophageal
cancer. How the authors interpret their positive correlation between esophageal
mucosal transformation and school year as well as annual income using the
cut-off value of 6 years of school and 150 US. Dose it indicate that learning more
and earning more might reduce the risk of esophageal cancer?
Discretionary Revisions
1. The description about the location of Feicheng in discussion has any meanful
value to this manuscript?
Major Compulsory Revisions
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Multi-susceptibility genes associated with esophageal squamous cell
cancer risk and their potential use to identify subjects at high risk
Version: 1Date:21 February 2011
Reviewer: YIH-GANG G GOAN
Reviewer's report:
This manuscript presented an interesting but not novel results regarding the
association between genetic polymorphism and esophageal neoplasm.
According to the results of this manuscript, there are several questions needed to
be clarified.
Major Compulsory Revisions
1. The patient numbers of each group with esophageal lesion as well as normal
control were silmilar in this study. How can the authors select patient
prospectively and get equally distributed population groups? Are there inclusion
and exclusion criteria for patient selection?
2. In this study, the results revealed the genotype of ALDH significantly
associatee with the development of esophageal cancer. However, risk factors for
esophageal squamous cell carcinoma are varied geographically. Cigarette
smoking, alcohol consumption, culture of life and condition of foods are
well-known risk factors for esophageal cancers. Did the authors analyze the
interaction effect of alcohol consumption on the relationship between genotype of
ALDH and the stages of esophageal mucosal transformation?
3. How many patients with ALDH2*2 were none alcohol consumption and got
esophageal cancer? How many patients with ALDH 1*1 were heavy drinkers and
got esophageal cancers?
4. Socio-economic status might correlate with the incidence of esophageal
cancer. How the authors interpret their positive correlation between esophageal
mucosal transformation and school year as well as annual income using the
cut-off value of 6 years of school and 150 US. Dose it indicate that learning more
and earning more might reduce the risk of esophageal cancer?
Discretionary Revisions
1. The description about the location of Feicheng in discussion has any meanful
value to this manuscript?
Major Compulsory Revisions
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Multi-susceptibility genes associated with esophageal squamous cell
cancer risk and their potential use to identify subjects at high risk
Version: 1Date:21 February 2011
Reviewer: YIH-GANG G GOAN
Reviewer's report:
This manuscript presented an interesting but not novel results regarding the
association between genetic polymorphism and esophageal neoplasm.
According to the results of this manuscript, there are several questions needed to
be clarified.
Major Compulsory Revisions
1. The patient numbers of each group with esophageal lesion as well as normal
control were silmilar in this study. How can the authors select patient
prospectively and get equally distributed population groups? Are there inclusion
and exclusion criteria for patient selection?
2. In this study, the results revealed the genotype of ALDH significantly
associatee with the development of esophageal cancer. However, risk factors for
esophageal squamous cell carcinoma are varied geographically. Cigarette
smoking, alcohol consumption, culture of life and condition of foods are
well-known risk factors for esophageal cancers. Did the authors analyze the
interaction effect of alcohol consumption on the relationship between genotype of
ALDH and the stages of esophageal mucosal transformation?
3. How many patients with ALDH2*2 were none alcohol consumption and got
esophageal cancer? How many patients with ALDH 1*1 were heavy drinkers and
got esophageal cancers?
4. Socio-economic status might correlate with the incidence of esophageal
cancer. How the authors interpret their positive correlation between esophageal
mucosal transformation and school year as well as annual income using the
cut-off value of 6 years of school and 150 US. Dose it indicate that learning more
and earning more might reduce the risk of esophageal cancer?
Discretionary Revisions
1. The description about the location of Feicheng in discussion has any meanful
value to this manuscript?
Major Compulsory Revisions
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant