Reviewer's report
Title:Two patients with intestinal failure requiring home parenteral nutrition, a
NOD2 mutation and tuberculous lymphadenitis
Version:3Date:31 December 2013
Reviewer: Zahra Babaei
Reviewer's report:
In this manuscript, the authors report two patients with intestinal failure who had
mutations in the NOD2 gene, receiving long term home parenteral nutrition. Both
patients were found to develop typical symptoms of an infection. Evidence was
highly suggestive of tuberculosis lymphadenitis. The authors concluded that
mutations in the NOD2 gene could be considered a risk factor for TB infections
as well as increasing the intestinal failure after surgical resection .
This is an Interesting manuscript and can be considered for publication in BMC
Gastroenterology after further revision.:
1-Since first patient received low doses of steroids for a long period of time, it
would be useful if the authors can include in the Discussion a potential link
between the steroid therapy and the relapse or the activation of TB some
infections. How the authors ruled out the possibilities of reactivating a
pre-existing infection rather than acquiring a new infection?
2- Under “Case Presentation”, Patient 1 ; line6 , “ the clinical course was
dominated by numerous infections complications …” the infections” did not
demonstrated . This sentence is vague. Please clarify.
3- Some abbreviations used such as IF and CD were not used in the manuscript
and must be deleted in abbreviations section .
4- References will need to be formatted according to BMC Gastroenterology
guidelines.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Two patients with intestinal failure requiring home parenteral nutrition, a
NOD2 mutation and tuberculous lymphadenitis
Version:3Date:31 December 2013
Reviewer: Zahra Babaei
Reviewer's report:
In this manuscript, the authors report two patients with intestinal failure who had
mutations in the NOD2 gene, receiving long term home parenteral nutrition. Both
patients were found to develop typical symptoms of an infection. Evidence was
highly suggestive of tuberculosis lymphadenitis. The authors concluded that
mutations in the NOD2 gene could be considered a risk factor for TB infections
as well as increasing the intestinal failure after surgical resection .
This is an Interesting manuscript and can be considered for publication in BMC
Gastroenterology after further revision.:
1-Since first patient received low doses of steroids for a long period of time, it
would be useful if the authors can include in the Discussion a potential link
between the steroid therapy and the relapse or the activation of TB some
infections. How the authors ruled out the possibilities of reactivating a
pre-existing infection rather than acquiring a new infection?
2- Under “Case Presentation”, Patient 1 ; line6 , “ the clinical course was
dominated by numerous infections complications …” the infections” did not
demonstrated . This sentence is vague. Please clarify.
3- Some abbreviations used such as IF and CD were not used in the manuscript
and must be deleted in abbreviations section .
4- References will need to be formatted according to BMC Gastroenterology
guidelines.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Two patients with intestinal failure requiring home parenteral nutrition, a
NOD2 mutation and tuberculous lymphadenitis
Version:3Date:31 December 2013
Reviewer: Zahra Babaei
Reviewer's report:
In this manuscript, the authors report two patients with intestinal failure who had
mutations in the NOD2 gene, receiving long term home parenteral nutrition. Both
patients were found to develop typical symptoms of an infection. Evidence was
highly suggestive of tuberculosis lymphadenitis. The authors concluded that
mutations in the NOD2 gene could be considered a risk factor for TB infections
as well as increasing the intestinal failure after surgical resection .
This is an Interesting manuscript and can be considered for publication in BMC
Gastroenterology after further revision.:
1-Since first patient received low doses of steroids for a long period of time, it
would be useful if the authors can include in the Discussion a potential link
between the steroid therapy and the relapse or the activation of TB some
infections. How the authors ruled out the possibilities of reactivating a
pre-existing infection rather than acquiring a new infection?
2- Under “Case Presentation”, Patient 1 ; line6 , “ the clinical course was
dominated by numerous infections complications …” the infections” did not
demonstrated . This sentence is vague. Please clarify.
3- Some abbreviations used such as IF and CD were not used in the manuscript
and must be deleted in abbreviations section .
4- References will need to be formatted according to BMC Gastroenterology
guidelines.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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