Title: Blood flow assessment of gastric tube with indocyanine green fluorescence angiography
and postoperative endoscopy during esophagectomy: Indocyanine green enhancement time
indicated congestion
Version: 2 Date: 25 Jul 2024
Reviewer's report:
This study is well described the evaluation of the relationship between ICG fluorescence
angiography finding during esophagectomy and postoperative endoscopy finding. This study is
interesting. Therefore, This would be accepted after minor revision.
1) The author determined that the time cutoff value until ICG enhancement of the gastric tube
tip was 55 s with an area under the ROC curve. What is this cutoff value for ? Could you explain
more details about that ?
2) Is there any correlation between congestion and ischemia ?
3) Is there any reason why the author only performed the univariate and multivariate analyses
of factors related to mucosal congestion. How about the results of the ischemia?
4) In the Table 2, how about showing the results of the anastomotic leakage?
5) Is the argument that this study is not an appropriate predictive assessment of anastomotic
leakage because intraoperative ICG examination reflects venous congestion rather than arterial
blood flow? It would be better to clarify in the discussion section
Title: Blood flow assessment of gastric tube with indocyanine green fluorescence angiography
and postoperative endoscopy during esophagectomy: Indocyanine green enhancement time
indicated congestion
Version: 2 Date: 25 Jul 2024
Reviewer's report:
This study is well described the evaluation of the relationship between ICG fluorescence
angiography finding during esophagectomy and postoperative endoscopy finding. This study is
interesting. Therefore, This would be accepted after minor revision.
1) The author determined that the time cutoff value until ICG enhancement of the gastric tube
tip was 55 s with an area under the ROC curve. What is this cutoff value for ? Could you explain
more details about that ?
2) Is there any correlation between congestion and ischemia ?
3) Is there any reason why the author only performed the univariate and multivariate analyses
of factors related to mucosal congestion. How about the results of the ischemia?
4) In the Table 2, how about showing the results of the anastomotic leakage?
5) Is the argument that this study is not an appropriate predictive assessment of anastomotic
leakage because intraoperative ICG examination reflects venous congestion rather than arterial
blood flow? It would be better to clarify in the discussion section
Please review this paper.
user
Title: Blood flow assessment of gastric tube with indocyanine green fluorescence angiography
and postoperative endoscopy during esophagectomy: Indocyanine green enhancement time
indicated congestion
Version: 2 Date: 25 Jul 2024
Reviewer's report:
This study is well described the evaluation of the relationship between ICG fluorescence
angiography finding during esophagectomy and postoperative endoscopy finding. This study is
interesting. Therefore, This would be accepted after minor revision.
1) The author determined that the time cutoff value until ICG enhancement of the gastric tube
tip was 55 s with an area under the ROC curve. What is this cutoff value for ? Could you explain
more details about that ?
2) Is there any correlation between congestion and ischemia ?
3) Is there any reason why the author only performed the univariate and multivariate analyses
of factors related to mucosal congestion. How about the results of the ischemia?
4) In the Table 2, how about showing the results of the anastomotic leakage?
5) Is the argument that this study is not an appropriate predictive assessment of anastomotic
leakage because intraoperative ICG examination reflects venous congestion rather than arterial
blood flow? It would be better to clarify in the discussion section
assistant