Review er’s report  
 
Title: Risk Factors  for Complications and Mortality of Percutaneous Endoscopic Gastrostomy 
Insertion  
 
Version: 0 Date: 21 Mar 2018  
 
Reviewer: Jiing -Chyuan Luo  
 
Reviewer's report:  
 
The authors aimed to determine risk factors associated with complications and 30 -day mortality 
after PEG based on 11 years of experience with 401 patients in a single tertiary  hospital. They 
found that early mortality within 30 days was associated with chronic kidney disease, low 
platelet levels, and high CRP levels; chronic complications after PEG was associated with older 
patients and those with diabetes mellitus after PEG. T here was no new finding when compared 
with previous studies.  
   
Major Comments  
1. Some important risk factor for mortality and chronic complication were not enrolled, such as 
underlying disease ( cirrhosis, COPD, malignancy, performance status, CVA or other  neuro 
condition and lab data (prothrombin time). You should have the data for analysis.  
 
2. Do you have the data of the causes of 30 -day mortality. It is interesting and important to 
physician performing PEG.  
 
3. What is the definite of lower platelet, higher  CRP, chronic kidney disease ?   
 
Minor  
1. You should have the p value in Table 1, the column of "total" can be removed.  
 
2. In Table 2, the column of "total" can be removed.  
 
3. Table 3, please remove 95% CI in univariate analysis, you did not show the data of  95% CI.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comme nts to the authors.  
 
No 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please expla in in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the public ation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If you r reply is yes to any, please give details below.  
 
'I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted  for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org /licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Review er’s report  
 
Title: Risk Factors  for Complications and Mortality of Percutaneous Endoscopic Gastrostomy 
Insertion  
 
Version: 0 Date: 21 Mar 2018  
 
Reviewer: Jiing -Chyuan Luo  
 
Reviewer's report:  
 
The authors aimed to determine risk factors associated with complications and 30 -day mortality 
after PEG based on 11 years of experience with 401 patients in a single tertiary  hospital. They 
found that early mortality within 30 days was associated with chronic kidney disease, low 
platelet levels, and high CRP levels; chronic complications after PEG was associated with older 
patients and those with diabetes mellitus after PEG. T here was no new finding when compared 
with previous studies.  
   
Major Comments  
1. Some important risk factor for mortality and chronic complication were not enrolled, such as 
underlying disease ( cirrhosis, COPD, malignancy, performance status, CVA or other  neuro 
condition and lab data (prothrombin time). You should have the data for analysis.  
 
2. Do you have the data of the causes of 30 -day mortality. It is interesting and important to 
physician performing PEG.  
 
3. What is the definite of lower platelet, higher  CRP, chronic kidney disease ?   
 
Minor  
1. You should have the p value in Table 1, the column of "total" can be removed.  
 
2. In Table 2, the column of "total" can be removed.  
 
3. Table 3, please remove 95% CI in univariate analysis, you did not show the data of  95% CI.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comme nts to the authors.  
 
No 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please expla in in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the public ation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If you r reply is yes to any, please give details below.  
 
'I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted  for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org /licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Review er’s report  
 
Title: Risk Factors  for Complications and Mortality of Percutaneous Endoscopic Gastrostomy 
Insertion  
 
Version: 0 Date: 21 Mar 2018  
 
Reviewer: Jiing -Chyuan Luo  
 
Reviewer's report:  
 
The authors aimed to determine risk factors associated with complications and 30 -day mortality 
after PEG based on 11 years of experience with 401 patients in a single tertiary  hospital. They 
found that early mortality within 30 days was associated with chronic kidney disease, low 
platelet levels, and high CRP levels; chronic complications after PEG was associated with older 
patients and those with diabetes mellitus after PEG. T here was no new finding when compared 
with previous studies.  
   
Major Comments  
1. Some important risk factor for mortality and chronic complication were not enrolled, such as 
underlying disease ( cirrhosis, COPD, malignancy, performance status, CVA or other  neuro 
condition and lab data (prothrombin time). You should have the data for analysis.  
 
2. Do you have the data of the causes of 30 -day mortality. It is interesting and important to 
physician performing PEG.  
 
3. What is the definite of lower platelet, higher  CRP, chronic kidney disease ?   
 
Minor  
1. You should have the p value in Table 1, the column of "total" can be removed.  
 
2. In Table 2, the column of "total" can be removed.  
 
3. Table 3, please remove 95% CI in univariate analysis, you did not show the data of  95% CI.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comme nts to the authors.  
 
No 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please expla in in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the public ation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If you r reply is yes to any, please give details below.  
 
'I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted  for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org /licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant