Title: Global and national trends in years of life lost and years lived with disability caused by
 three common gastrointestinal cancers from 1990 to 2019
Version: 1 Date: 02 Nov 2021
Reviewer:  Paulina Paciej-go##biowska
Reviewer's report:
1. The title of the manuscript is "Global and national trends in years of life lost and years lived
with disability caused by gastrointestinal cancers from 1990 to 2019". Why did the Authors
decide not to include pancreatic cancer in their analysis?
2. Abstract: "Among countries, the largest decrease in trend of YLLs was that caused by
stomacher cancer in the Republic of Korea (EAPC = #5.88, 95%CI: #6.07 to #5.69). However,
the most pronounced increasing trend of YLDs was that caused by colorectal cancer in China
(EAPC = 4.63, 95%CI: 4.31 to 4.94)". I guess the Authors decided to highlight these results
because they are relevant to their location, but I am not sure these are the most important for
"average" reader.
2. DALY abbreviation should be explained while used for the first time in the text.
3. Background section: "During the period 2006-2016, the age-Standardized rate (ASR) of
YLLs caused by stomach cancer, colorectal cancer, and esophageal cancer had changed with
the estimated #24.7%, #8.9%, and #22.0%, respectively[3]. Globally , the number of DALYs
caused by colorectal cancer was 19.0 million in 2017, comprise of 95% from YLLs sand 5%
from YLDs; DALYs caused by stomach cancer was 19.1 million in 2019, with the 98% came
from YLLs and 2% from YLDs [4]". What was the proportion of YLLs and YLDs for esophageal
cancer?
4. Background section: "The clinical outcomes of gastrointestinal cancers were mainly promoted
by the progress in screening, treatment and management [5]. For example, population-based
early screening programs have been available since 1990s, and progress in the survival
of colorectal cancer were achieved in the United States and Japan [6]. Meanwhile, China
government had taken actions to improve the health care systems [7, 8], and the YLLs of stomach
cancer and colorectal cancer declined in recent years [9, 10]."  I would rather get more detailed
information on intervention mentioned above.
5. Material and methods section: "YLLs are the difference between death cases and standard life
expectancy at the age of death". I disagree with this statement. The definition of YLLs should
be clarified.
6. Discussion section: "YLDs caused by colorectal cancer had obvious increasing trends in
China, in where appeared the increasing burden of colorectal cancer in the rural areas [36], and
a significant upward trend in the youths (aged 15-49 years) [37]". Could this topic be discussed
in more detail?
7. The manuscript should be revised by English translator - many language errors appear in the
text.
Title: Global and national trends in years of life lost and years lived with disability caused by
 three common gastrointestinal cancers from 1990 to 2019
Version: 1 Date: 02 Nov 2021
Reviewer:  Paulina Paciej-go##biowska
Reviewer's report:
1. The title of the manuscript is "Global and national trends in years of life lost and years lived
with disability caused by gastrointestinal cancers from 1990 to 2019". Why did the Authors
decide not to include pancreatic cancer in their analysis?
2. Abstract: "Among countries, the largest decrease in trend of YLLs was that caused by
stomacher cancer in the Republic of Korea (EAPC = #5.88, 95%CI: #6.07 to #5.69). However,
the most pronounced increasing trend of YLDs was that caused by colorectal cancer in China
(EAPC = 4.63, 95%CI: 4.31 to 4.94)". I guess the Authors decided to highlight these results
because they are relevant to their location, but I am not sure these are the most important for
"average" reader.
2. DALY abbreviation should be explained while used for the first time in the text.
3. Background section: "During the period 2006-2016, the age-Standardized rate (ASR) of
YLLs caused by stomach cancer, colorectal cancer, and esophageal cancer had changed with
the estimated #24.7%, #8.9%, and #22.0%, respectively[3]. Globally , the number of DALYs
caused by colorectal cancer was 19.0 million in 2017, comprise of 95% from YLLs sand 5%
from YLDs; DALYs caused by stomach cancer was 19.1 million in 2019, with the 98% came
from YLLs and 2% from YLDs [4]". What was the proportion of YLLs and YLDs for esophageal
cancer?
4. Background section: "The clinical outcomes of gastrointestinal cancers were mainly promoted
by the progress in screening, treatment and management [5]. For example, population-based
early screening programs have been available since 1990s, and progress in the survival
of colorectal cancer were achieved in the United States and Japan [6]. Meanwhile, China
government had taken actions to improve the health care systems [7, 8], and the YLLs of stomach
cancer and colorectal cancer declined in recent years [9, 10]."  I would rather get more detailed
information on intervention mentioned above.
5. Material and methods section: "YLLs are the difference between death cases and standard life
expectancy at the age of death". I disagree with this statement. The definition of YLLs should
be clarified.
6. Discussion section: "YLDs caused by colorectal cancer had obvious increasing trends in
China, in where appeared the increasing burden of colorectal cancer in the rural areas [36], and
a significant upward trend in the youths (aged 15-49 years) [37]". Could this topic be discussed
in more detail?
7. The manuscript should be revised by English translator - many language errors appear in the
text.
Please review this paper.
user
Title: Global and national trends in years of life lost and years lived with disability caused by
 three common gastrointestinal cancers from 1990 to 2019
Version: 1 Date: 02 Nov 2021
Reviewer:  Paulina Paciej-go##biowska
Reviewer's report:
1. The title of the manuscript is "Global and national trends in years of life lost and years lived
with disability caused by gastrointestinal cancers from 1990 to 2019". Why did the Authors
decide not to include pancreatic cancer in their analysis?
2. Abstract: "Among countries, the largest decrease in trend of YLLs was that caused by
stomacher cancer in the Republic of Korea (EAPC = #5.88, 95%CI: #6.07 to #5.69). However,
the most pronounced increasing trend of YLDs was that caused by colorectal cancer in China
(EAPC = 4.63, 95%CI: 4.31 to 4.94)". I guess the Authors decided to highlight these results
because they are relevant to their location, but I am not sure these are the most important for
"average" reader.
2. DALY abbreviation should be explained while used for the first time in the text.
3. Background section: "During the period 2006-2016, the age-Standardized rate (ASR) of
YLLs caused by stomach cancer, colorectal cancer, and esophageal cancer had changed with
the estimated #24.7%, #8.9%, and #22.0%, respectively[3]. Globally , the number of DALYs
caused by colorectal cancer was 19.0 million in 2017, comprise of 95% from YLLs sand 5%
from YLDs; DALYs caused by stomach cancer was 19.1 million in 2019, with the 98% came
from YLLs and 2% from YLDs [4]". What was the proportion of YLLs and YLDs for esophageal
cancer?
4. Background section: "The clinical outcomes of gastrointestinal cancers were mainly promoted
by the progress in screening, treatment and management [5]. For example, population-based
early screening programs have been available since 1990s, and progress in the survival
of colorectal cancer were achieved in the United States and Japan [6]. Meanwhile, China
government had taken actions to improve the health care systems [7, 8], and the YLLs of stomach
cancer and colorectal cancer declined in recent years [9, 10]."  I would rather get more detailed
information on intervention mentioned above.
5. Material and methods section: "YLLs are the difference between death cases and standard life
expectancy at the age of death". I disagree with this statement. The definition of YLLs should
be clarified.
6. Discussion section: "YLDs caused by colorectal cancer had obvious increasing trends in
China, in where appeared the increasing burden of colorectal cancer in the rural areas [36], and
a significant upward trend in the youths (aged 15-49 years) [37]". Could this topic be discussed
in more detail?
7. The manuscript should be revised by English translator - many language errors appear in the
text.
assistant