Title:  The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control
study
Version: 2 Date: 30 Jun 2024
Reviewer's report:
1. Authors stated they included “first-degree relatives” of the patients in the abstract and
discussion, while we also saw “family members” in the study community. Authors stated the
they selected first-degree relatives for the control group as they “had the same environmental
conditions as the sick subjects”, and it made the spouse a reasonable choice for the control group.
Then why they select first-degree relatives as the control?
2. The sample size was small, and authors should state how they calculated the sample size.
Authors should state the definition of “respond to treatment methods”, and also explain why
they separated UC patients into “responded to treatment” and “did not respond to treatment”.
3. Participants with high CRP in the UC groups and control groups were 17 (70.83)/18 (78.26)
and 14 (58.33)/12 (52.17), authors should explain why the controls had high CRP, what were
the concomitant diseases of these participants.
4. More work is needed for a logical discussion.
Title:  The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control
study
Version: 2 Date: 30 Jun 2024
Reviewer's report:
1. Authors stated they included “first-degree relatives” of the patients in the abstract and
discussion, while we also saw “family members” in the study community. Authors stated the
they selected first-degree relatives for the control group as they “had the same environmental
conditions as the sick subjects”, and it made the spouse a reasonable choice for the control group.
Then why they select first-degree relatives as the control?
2. The sample size was small, and authors should state how they calculated the sample size.
Authors should state the definition of “respond to treatment methods”, and also explain why
they separated UC patients into “responded to treatment” and “did not respond to treatment”.
3. Participants with high CRP in the UC groups and control groups were 17 (70.83)/18 (78.26)
and 14 (58.33)/12 (52.17), authors should explain why the controls had high CRP, what were
the concomitant diseases of these participants.
4. More work is needed for a logical discussion.
Please review this paper.
user
Title:  The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control
study
Version: 2 Date: 30 Jun 2024
Reviewer's report:
1. Authors stated they included “first-degree relatives” of the patients in the abstract and
discussion, while we also saw “family members” in the study community. Authors stated the
they selected first-degree relatives for the control group as they “had the same environmental
conditions as the sick subjects”, and it made the spouse a reasonable choice for the control group.
Then why they select first-degree relatives as the control?
2. The sample size was small, and authors should state how they calculated the sample size.
Authors should state the definition of “respond to treatment methods”, and also explain why
they separated UC patients into “responded to treatment” and “did not respond to treatment”.
3. Participants with high CRP in the UC groups and control groups were 17 (70.83)/18 (78.26)
and 14 (58.33)/12 (52.17), authors should explain why the controls had high CRP, what were
the concomitant diseases of these participants.
4. More work is needed for a logical discussion.
assistant