Title: Association of pan-immune-inflammatory value with metabolic dysfunction-associated
steatotic liver disease: findings from NHANES 2017-2020
Version: 0 Date: 27 Nov 2024
Reviewer's report:
In this manuscript entitled “Association of pan-immune-inflammatory value with metabolic
dysfunction-associated steatotic liver disease: findings from NHANES 2017-2020”, the authors
examined the association between inflammation markers and metabolic dysfunction-associated
steatotic liver disease (MASLD). While this is an interesting study, there are some concerns
which should be clarified.
Major comments
1. In the introduction, the authors should explain the epidemiology of MASLD in general
population. (PMID: 38398471).
2. The manuscript does not clearly explain the rationale for selecting the covariates used in the
multivariavle logistic regression models.
3. Body fat accumulation can cause MASLD and inflammation. The authors should make a
discussion in the pathophysiology of MASLD in terms of body composition (PMID: 37143429).
4. In conclusion, the authors explained that “This relationship provides new insights into the
screening, prevention, and management of MASLD.” However, the authors have not performed
ROC analysis showing the sensitivity, specificity, positive predictive value, negative predictive
value, which must be evaluated to draw this conclusion.
Minor comments
1. The authors should add the references for the diagnosis of MASLD, CAP cutoff value, and
calculation of PIV in this study.
2. “Multivariate” should be changed to “multivariable”.
3. Minor grammatical errors and typos are present. A thorough language review is recommended
to improve the manuscript's polish and readability.
Title: Association of pan-immune-inflammatory value with metabolic dysfunction-associated
steatotic liver disease: findings from NHANES 2017-2020
Version: 0 Date: 27 Nov 2024
Reviewer's report:
In this manuscript entitled “Association of pan-immune-inflammatory value with metabolic
dysfunction-associated steatotic liver disease: findings from NHANES 2017-2020”, the authors
examined the association between inflammation markers and metabolic dysfunction-associated
steatotic liver disease (MASLD). While this is an interesting study, there are some concerns
which should be clarified.
Major comments
1. In the introduction, the authors should explain the epidemiology of MASLD in general
population. (PMID: 38398471).
2. The manuscript does not clearly explain the rationale for selecting the covariates used in the
multivariavle logistic regression models.
3. Body fat accumulation can cause MASLD and inflammation. The authors should make a
discussion in the pathophysiology of MASLD in terms of body composition (PMID: 37143429).
4. In conclusion, the authors explained that “This relationship provides new insights into the
screening, prevention, and management of MASLD.” However, the authors have not performed
ROC analysis showing the sensitivity, specificity, positive predictive value, negative predictive
value, which must be evaluated to draw this conclusion.
Minor comments
1. The authors should add the references for the diagnosis of MASLD, CAP cutoff value, and
calculation of PIV in this study.
2. “Multivariate” should be changed to “multivariable”.
3. Minor grammatical errors and typos are present. A thorough language review is recommended
to improve the manuscript's polish and readability.
Please review this paper.
user
Title: Association of pan-immune-inflammatory value with metabolic dysfunction-associated
steatotic liver disease: findings from NHANES 2017-2020
Version: 0 Date: 27 Nov 2024
Reviewer's report:
In this manuscript entitled “Association of pan-immune-inflammatory value with metabolic
dysfunction-associated steatotic liver disease: findings from NHANES 2017-2020”, the authors
examined the association between inflammation markers and metabolic dysfunction-associated
steatotic liver disease (MASLD). While this is an interesting study, there are some concerns
which should be clarified.
Major comments
1. In the introduction, the authors should explain the epidemiology of MASLD in general
population. (PMID: 38398471).
2. The manuscript does not clearly explain the rationale for selecting the covariates used in the
multivariavle logistic regression models.
3. Body fat accumulation can cause MASLD and inflammation. The authors should make a
discussion in the pathophysiology of MASLD in terms of body composition (PMID: 37143429).
4. In conclusion, the authors explained that “This relationship provides new insights into the
screening, prevention, and management of MASLD.” However, the authors have not performed
ROC analysis showing the sensitivity, specificity, positive predictive value, negative predictive
value, which must be evaluated to draw this conclusion.
Minor comments
1. The authors should add the references for the diagnosis of MASLD, CAP cutoff value, and
calculation of PIV in this study.
2. “Multivariate” should be changed to “multivariable”.
3. Minor grammatical errors and typos are present. A thorough language review is recommended
to improve the manuscript's polish and readability.
assistant