Title: Only repeatedly elevated IgG4 levels in primary sclerosing cholangitis may distinguish
a particular patient phenotype
Version: 2 Date: 23 Jun 2024
Reviewer's report:
The authors have adequately addressed most of my comments, but the main problem regarding
the very limited study population and the results showing no differences in death, cirrhosis or
liver transplantation between grpuops  do not support the authors' conclusions, that sequential
determinations of S- IgG4 levels may be of clinical benefit to more precisely identify those
individuals who are at increased risk of disease progression and thus increased morbidity and
mortality.
This conclusion cannot be drawn from the results and it should be rephrased.
Title: Only repeatedly elevated IgG4 levels in primary sclerosing cholangitis may distinguish
a particular patient phenotype
Version: 2 Date: 23 Jun 2024
Reviewer's report:
The authors have adequately addressed most of my comments, but the main problem regarding
the very limited study population and the results showing no differences in death, cirrhosis or
liver transplantation between grpuops  do not support the authors' conclusions, that sequential
determinations of S- IgG4 levels may be of clinical benefit to more precisely identify those
individuals who are at increased risk of disease progression and thus increased morbidity and
mortality.
This conclusion cannot be drawn from the results and it should be rephrased.
Please review this paper.
user
Title: Only repeatedly elevated IgG4 levels in primary sclerosing cholangitis may distinguish
a particular patient phenotype
Version: 2 Date: 23 Jun 2024
Reviewer's report:
The authors have adequately addressed most of my comments, but the main problem regarding
the very limited study population and the results showing no differences in death, cirrhosis or
liver transplantation between grpuops  do not support the authors' conclusions, that sequential
determinations of S- IgG4 levels may be of clinical benefit to more precisely identify those
individuals who are at increased risk of disease progression and thus increased morbidity and
mortality.
This conclusion cannot be drawn from the results and it should be rephrased.
assistant