Title: Identification of differentially methylated regions associated with both liver fibrosis and
hepatocellular carcinoma
Version: 4 Date: 09 Jan 2024
Reviewer's report:
In the revised version the authors have provided additional data to strengthen the conclusions
of the manuscript. However, some of the results as presented in the abstract are not their own
data. For  example, the following sentences in the abstract
"These genes altered the epigenetic regulation in liver cells, leading to the development of HCC.
Knockdown of KAZN inhibits the differentiation and stimulates proliferation, suggesting that
the decreased expression of KAZN inhibits the differentiation and stimulates the proliferation
of liver cells, leading to the development of HCC." are  not based on their own data. Therefore,
these cannot be included in the results section without proper citation. Abstract should contain
only their findings based on their analysis.
Title: Identification of differentially methylated regions associated with both liver fibrosis and
hepatocellular carcinoma
Version: 4 Date: 09 Jan 2024
Reviewer's report:
In the revised version the authors have provided additional data to strengthen the conclusions
of the manuscript. However, some of the results as presented in the abstract are not their own
data. For  example, the following sentences in the abstract
"These genes altered the epigenetic regulation in liver cells, leading to the development of HCC.
Knockdown of KAZN inhibits the differentiation and stimulates proliferation, suggesting that
the decreased expression of KAZN inhibits the differentiation and stimulates the proliferation
of liver cells, leading to the development of HCC." are  not based on their own data. Therefore,
these cannot be included in the results section without proper citation. Abstract should contain
only their findings based on their analysis.
Please review this paper.
user
Title: Identification of differentially methylated regions associated with both liver fibrosis and
hepatocellular carcinoma
Version: 4 Date: 09 Jan 2024
Reviewer's report:
In the revised version the authors have provided additional data to strengthen the conclusions
of the manuscript. However, some of the results as presented in the abstract are not their own
data. For  example, the following sentences in the abstract
"These genes altered the epigenetic regulation in liver cells, leading to the development of HCC.
Knockdown of KAZN inhibits the differentiation and stimulates proliferation, suggesting that
the decreased expression of KAZN inhibits the differentiation and stimulates the proliferation
of liver cells, leading to the development of HCC." are  not based on their own data. Therefore,
these cannot be included in the results section without proper citation. Abstract should contain
only their findings based on their analysis.
assistant