Reviewer’ s report
Title: A Retrospective Study on the Association of Gastrointestinal Symptoms in Children with
Low Lactase Activity and Low Activity of Other Disaccharidases
Version: 0Date: 24 Jul 2019
Reviewer: Alejandra Cardelle-Cobas
Reviewer's report:
The article deals with the association of low activity of disaccharidases and general
gastrointestinal symptoms in children. From my point of view, the manuscript content is, ingeneral, well written and with adequates tables including the data obtained. The methodology isadapted to the objectives of the study and the underlying science is sound. In fact, I find that theseproblems associated to low disaccharidases activity should be more deeply studied since thenumber of cases is continuosly increasing. As the authors indicate in their work more largersamples size are necessary to evidence this relationship.The purposes of the work and the experimental findings are clearly described and the resultscontribute to the previous studies developed. I only have a suggestion for the authors, it should beinteresting to have include some conclusions about if differences were found, or not, depending onthe age (teenager, pre-teenager), on the race or on the sex. With a sample including 347 children itshould be a shame not to draw any more conclusionsIn any case, I consider the manuscript should be accepted for publication
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interest
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’ s report
Title: A Retrospective Study on the Association of Gastrointestinal Symptoms in Children with
Low Lactase Activity and Low Activity of Other Disaccharidases
Version: 0Date: 24 Jul 2019
Reviewer: Alejandra Cardelle-Cobas
Reviewer's report:
The article deals with the association of low activity of disaccharidases and general
gastrointestinal symptoms in children. From my point of view, the manuscript content is, ingeneral, well written and with adequates tables including the data obtained. The methodology isadapted to the objectives of the study and the underlying science is sound. In fact, I find that theseproblems associated to low disaccharidases activity should be more deeply studied since thenumber of cases is continuosly increasing. As the authors indicate in their work more largersamples size are necessary to evidence this relationship.The purposes of the work and the experimental findings are clearly described and the resultscontribute to the previous studies developed. I only have a suggestion for the authors, it should beinteresting to have include some conclusions about if differences were found, or not, depending onthe age (teenager, pre-teenager), on the race or on the sex. With a sample including 347 children itshould be a shame not to draw any more conclusionsIn any case, I consider the manuscript should be accepted for publication
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interest
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’ s report
Title: A Retrospective Study on the Association of Gastrointestinal Symptoms in Children with
Low Lactase Activity and Low Activity of Other Disaccharidases
Version: 0Date: 24 Jul 2019
Reviewer: Alejandra Cardelle-Cobas
Reviewer's report:
The article deals with the association of low activity of disaccharidases and general
gastrointestinal symptoms in children. From my point of view, the manuscript content is, ingeneral, well written and with adequates tables including the data obtained. The methodology isadapted to the objectives of the study and the underlying science is sound. In fact, I find that theseproblems associated to low disaccharidases activity should be more deeply studied since thenumber of cases is continuosly increasing. As the authors indicate in their work more largersamples size are necessary to evidence this relationship.The purposes of the work and the experimental findings are clearly described and the resultscontribute to the previous studies developed. I only have a suggestion for the authors, it should beinteresting to have include some conclusions about if differences were found, or not, depending onthe age (teenager, pre-teenager), on the race or on the sex. With a sample including 347 children itshould be a shame not to draw any more conclusionsIn any case, I consider the manuscript should be accepted for publication
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
YesAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interest
I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant