Title: The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal
cancer
Version: 1 Date: 10 Jan 2022
Reviewer:  Isabel Portillo
Reviewer's report:
Dear authors,
I am pleased to review your manuscript. I consider very useful your study. But I would like to
remark:
row 98: " All objects recruited signed...." Are patients objects? Maybe is most respecful: All
patients, all participants....
Figures are not very well explained and some times is difficult to interpret them.
row 270: "CRCs also differs in age and gender.." In that case the appropriate word is sex". And
¿could you explain better the differences, please?
Conclusions: Could you give a practical guidance for clinicians, please?
Thanks a lot
Title: The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal
cancer
Version: 1 Date: 10 Jan 2022
Reviewer:  Isabel Portillo
Reviewer's report:
Dear authors,
I am pleased to review your manuscript. I consider very useful your study. But I would like to
remark:
row 98: " All objects recruited signed...." Are patients objects? Maybe is most respecful: All
patients, all participants....
Figures are not very well explained and some times is difficult to interpret them.
row 270: "CRCs also differs in age and gender.." In that case the appropriate word is sex". And
¿could you explain better the differences, please?
Conclusions: Could you give a practical guidance for clinicians, please?
Thanks a lot
Please review this paper.
user
Title: The methylation of SDC2 and TFPI2 defined three methylator phenotypes of colorectal
cancer
Version: 1 Date: 10 Jan 2022
Reviewer:  Isabel Portillo
Reviewer's report:
Dear authors,
I am pleased to review your manuscript. I consider very useful your study. But I would like to
remark:
row 98: " All objects recruited signed...." Are patients objects? Maybe is most respecful: All
patients, all participants....
Figures are not very well explained and some times is difficult to interpret them.
row 270: "CRCs also differs in age and gender.." In that case the appropriate word is sex". And
¿could you explain better the differences, please?
Conclusions: Could you give a practical guidance for clinicians, please?
Thanks a lot
assistant