Title: The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-
omics Mendelian randomization study
Version: 0 Date: 18 May 2024
Reviewer:  Nicoleta Leopa
Reviewer's report:
The topic under discussion is an important one and you have described some interesting
findings. The authors of the article " The relationship between innate/adaptive immunity and
gastrointestinal cancer : a multi-omics Mendelian randomization study" respected the structure
imposed by the journal, it is an article of interest for specialty readers, together with other similar
articles it may have an impact on the development of future guidelines on gastrointestinal cancer.
To strengthen this manuscript, consider the following:
- Page 3,” chimaeric antigen receptor (CAR)” is chimeric antigen receptors (CARs)
- - section MM: flow chart, primary point, secondary endpoint, after that IBD, statistical method
used and statistical tests used.
- the statistical analysis part is far too detailed, it should be rewritten in a way that is useful to
the reader
- how was the randomization performed?
- The authors should emphasize more the innovation of the study.
- the conclusion should be rewritten, in a sentence that clearly shows the studied genes and their
connection with gastrointestinal cancer.
Title: The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-
omics Mendelian randomization study
Version: 0 Date: 18 May 2024
Reviewer:  Nicoleta Leopa
Reviewer's report:
The topic under discussion is an important one and you have described some interesting
findings. The authors of the article " The relationship between innate/adaptive immunity and
gastrointestinal cancer : a multi-omics Mendelian randomization study" respected the structure
imposed by the journal, it is an article of interest for specialty readers, together with other similar
articles it may have an impact on the development of future guidelines on gastrointestinal cancer.
To strengthen this manuscript, consider the following:
- Page 3,” chimaeric antigen receptor (CAR)” is chimeric antigen receptors (CARs)
- - section MM: flow chart, primary point, secondary endpoint, after that IBD, statistical method
used and statistical tests used.
- the statistical analysis part is far too detailed, it should be rewritten in a way that is useful to
the reader
- how was the randomization performed?
- The authors should emphasize more the innovation of the study.
- the conclusion should be rewritten, in a sentence that clearly shows the studied genes and their
connection with gastrointestinal cancer.
Please review this paper.
user
Title: The relationship between innate/adaptive immunity and gastrointestinal cancer : a multi-
omics Mendelian randomization study
Version: 0 Date: 18 May 2024
Reviewer:  Nicoleta Leopa
Reviewer's report:
The topic under discussion is an important one and you have described some interesting
findings. The authors of the article " The relationship between innate/adaptive immunity and
gastrointestinal cancer : a multi-omics Mendelian randomization study" respected the structure
imposed by the journal, it is an article of interest for specialty readers, together with other similar
articles it may have an impact on the development of future guidelines on gastrointestinal cancer.
To strengthen this manuscript, consider the following:
- Page 3,” chimaeric antigen receptor (CAR)” is chimeric antigen receptors (CARs)
- - section MM: flow chart, primary point, secondary endpoint, after that IBD, statistical method
used and statistical tests used.
- the statistical analysis part is far too detailed, it should be rewritten in a way that is useful to
the reader
- how was the randomization performed?
- The authors should emphasize more the innovation of the study.
- the conclusion should be rewritten, in a sentence that clearly shows the studied genes and their
connection with gastrointestinal cancer.
assistant