Title: Evaluation of the association between periodontitis and inflammatory bowel disease: A
Systematic Review and Meta-analysis
Version: 0 Date: 13 May 2025
Reviewer's report:
Limited Innovation#
The study design shows significant overlap with previous systematic reviews, such as “A
systematic review and network meta-analysis of the association between periodontitis and
inflammatory bowel diseases” and “Bidirectional association between oral diseases caused by
plaque and the inflammatory bowel disease: A systematic review and meta-analysis” . It lacks
novel hypotheses and methodological improvements. To enhance its scientific value, we suggest
including mechanistic explorations of oral-gut axis interactions, like microbial dysbiosis and
shared immune pathways.
Overinterpretation of Findings#
The conclusion that " patients with UC exhibit a significantly greater propensity for developing
periodontitis than those with CD, as indicated by an OR of 2.313 (95% CI: 1.891–2.828)“,
should be interpreted with caution. Ayati after analyzing 17 studies (n = 9,458), found
similar periodontitis risks between UC and CD patients (OR = 0.96, 95% CI: 0.65 - 1.43).
The discrepancies might be due to Diagnostic Variability and Heterogeneous Confounder
Adjustment.
Title: Evaluation of the association between periodontitis and inflammatory bowel disease: A
Systematic Review and Meta-analysis
Version: 0 Date: 13 May 2025
Reviewer's report:
Limited Innovation#
The study design shows significant overlap with previous systematic reviews, such as “A
systematic review and network meta-analysis of the association between periodontitis and
inflammatory bowel diseases” and “Bidirectional association between oral diseases caused by
plaque and the inflammatory bowel disease: A systematic review and meta-analysis” . It lacks
novel hypotheses and methodological improvements. To enhance its scientific value, we suggest
including mechanistic explorations of oral-gut axis interactions, like microbial dysbiosis and
shared immune pathways.
Overinterpretation of Findings#
The conclusion that " patients with UC exhibit a significantly greater propensity for developing
periodontitis than those with CD, as indicated by an OR of 2.313 (95% CI: 1.891–2.828)“,
should be interpreted with caution. Ayati after analyzing 17 studies (n = 9,458), found
similar periodontitis risks between UC and CD patients (OR = 0.96, 95% CI: 0.65 - 1.43).
The discrepancies might be due to Diagnostic Variability and Heterogeneous Confounder
Adjustment.
Please review this paper.
user
Title: Evaluation of the association between periodontitis and inflammatory bowel disease: A
Systematic Review and Meta-analysis
Version: 0 Date: 13 May 2025
Reviewer's report:
Limited Innovation#
The study design shows significant overlap with previous systematic reviews, such as “A
systematic review and network meta-analysis of the association between periodontitis and
inflammatory bowel diseases” and “Bidirectional association between oral diseases caused by
plaque and the inflammatory bowel disease: A systematic review and meta-analysis” . It lacks
novel hypotheses and methodological improvements. To enhance its scientific value, we suggest
including mechanistic explorations of oral-gut axis interactions, like microbial dysbiosis and
shared immune pathways.
Overinterpretation of Findings#
The conclusion that " patients with UC exhibit a significantly greater propensity for developing
periodontitis than those with CD, as indicated by an OR of 2.313 (95% CI: 1.891–2.828)“,
should be interpreted with caution. Ayati after analyzing 17 studies (n = 9,458), found
similar periodontitis risks between UC and CD patients (OR = 0.96, 95% CI: 0.65 - 1.43).
The discrepancies might be due to Diagnostic Variability and Heterogeneous Confounder
Adjustment.
assistant