Title: Nomogram for predicting rebleeding after initial endoscopic epinephrine injection
monotherapy hemostasis in patients with peptic ulcer bleeding: a retrospective cohort study
Version: 1 Date: 10 Jul 2022
Reviewer's report:
This article focused on the efficiency of EI monotherapy for PUB patients. The authors analyzed
the difference between non-rebleeding and rebleeding cases, risks for rebleeding after initial
endoscopic hemostasis, and made ROC.
This report is possibly valuable in clarifying the real clinical situation under EI monotherapy.
However, there are several vital problems that need to explain or describe more precisely.
1. The authors should adopt Glasgow Blatchford Score (GBS) not Blatchford Score,  because
most recent guidelines recommended GBS.
2.  This retrospective study excluded Forrest Ia patients from the study population. Nevertheless,
the 25.5% of mortality due to rebleeding was quite high than the previous reports. It may contain
several factors such as incomplete endoscopic hemostasis at initial EI monotherapy, bad transfer
to additional surgery or IVR, and missing adequate timing for transfusion. The authors need to
discuss this point deeply.
3. This ROC was not validated and most of the factors were reported in previous prospective
studies, so it may not be necessary to add on the article.
Title: Nomogram for predicting rebleeding after initial endoscopic epinephrine injection
monotherapy hemostasis in patients with peptic ulcer bleeding: a retrospective cohort study
Version: 1 Date: 10 Jul 2022
Reviewer's report:
This article focused on the efficiency of EI monotherapy for PUB patients. The authors analyzed
the difference between non-rebleeding and rebleeding cases, risks for rebleeding after initial
endoscopic hemostasis, and made ROC.
This report is possibly valuable in clarifying the real clinical situation under EI monotherapy.
However, there are several vital problems that need to explain or describe more precisely.
1. The authors should adopt Glasgow Blatchford Score (GBS) not Blatchford Score,  because
most recent guidelines recommended GBS.
2.  This retrospective study excluded Forrest Ia patients from the study population. Nevertheless,
the 25.5% of mortality due to rebleeding was quite high than the previous reports. It may contain
several factors such as incomplete endoscopic hemostasis at initial EI monotherapy, bad transfer
to additional surgery or IVR, and missing adequate timing for transfusion. The authors need to
discuss this point deeply.
3. This ROC was not validated and most of the factors were reported in previous prospective
studies, so it may not be necessary to add on the article.
Please review this paper.
user
Title: Nomogram for predicting rebleeding after initial endoscopic epinephrine injection
monotherapy hemostasis in patients with peptic ulcer bleeding: a retrospective cohort study
Version: 1 Date: 10 Jul 2022
Reviewer's report:
This article focused on the efficiency of EI monotherapy for PUB patients. The authors analyzed
the difference between non-rebleeding and rebleeding cases, risks for rebleeding after initial
endoscopic hemostasis, and made ROC.
This report is possibly valuable in clarifying the real clinical situation under EI monotherapy.
However, there are several vital problems that need to explain or describe more precisely.
1. The authors should adopt Glasgow Blatchford Score (GBS) not Blatchford Score,  because
most recent guidelines recommended GBS.
2.  This retrospective study excluded Forrest Ia patients from the study population. Nevertheless,
the 25.5% of mortality due to rebleeding was quite high than the previous reports. It may contain
several factors such as incomplete endoscopic hemostasis at initial EI monotherapy, bad transfer
to additional surgery or IVR, and missing adequate timing for transfusion. The authors need to
discuss this point deeply.
3. This ROC was not validated and most of the factors were reported in previous prospective
studies, so it may not be necessary to add on the article.
assistant