Title: Genetic mechanism of #-alanine metabolic pathway affecting colorectal cancer prognosis
Version: 2 Date: 15 Apr 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to al
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The research article addresses an important translation research point
in the CRC patients, and the authors conducted suitable research methodology with reasonable
discussion.
New prognostic genetic marker for CRC patients is presented.
This is the first time to study the correlation between SNP of the B-Alanine and the DPYD
protein expression in colorectal cancer and its impact on survival of the patients.
This translational research needs further confirmatory studies.
Title: Genetic mechanism of #-alanine metabolic pathway affecting colorectal cancer prognosis
Version: 2 Date: 15 Apr 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to al
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The research article addresses an important translation research point
in the CRC patients, and the authors conducted suitable research methodology with reasonable
discussion.
New prognostic genetic marker for CRC patients is presented.
This is the first time to study the correlation between SNP of the B-Alanine and the DPYD
protein expression in colorectal cancer and its impact on survival of the patients.
This translational research needs further confirmatory studies.
Please review this paper.
user
Title: Genetic mechanism of #-alanine metabolic pathway affecting colorectal cancer prognosis
Version: 2 Date: 15 Apr 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to al
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The research article addresses an important translation research point
in the CRC patients, and the authors conducted suitable research methodology with reasonable
discussion.
New prognostic genetic marker for CRC patients is presented.
This is the first time to study the correlation between SNP of the B-Alanine and the DPYD
protein expression in colorectal cancer and its impact on survival of the patients.
This translational research needs further confirmatory studies.
assistant