Reviewer's report
Title:Cerebral microdialysis reflects the efficacy of Fractionated Plasma
Separation and Adsorption treatment of acute liver failure earlier than intracranial
pressure - a controlled study in pigs
Version: 1Date:3 April 2013
Reviewer: chuansheng wang
Reviewer's report:
Major compulsory revisions:
1. Title is misleading/unclear. I think the key finding of this paper is that
microdialysis data correlated with reduction of ICPs (which is significant compare
to reference 4 and 5 ) and potentially can be used as an early marker for
reduction of cerebral edema during the management of ALF in a pig model.
However, the title implies that FPSA is an effective therapy for acute liver failure.
2. Please clarify reference 4 and 5 in the introduction since their results are
critical for the authors work. In the discussion, the authors need to address the
different findings between their work using animal model and the other studies
using human ALF patients.
3. The introduction needs to be expanded so that it is clear to us what has been
done and what lead to your current hypothesis.
4. please elaborate on the reverse correlation between ICP and glutamine level
after 10 hours since it was not mentioned in the discussion. The impression given
is that you study is consistent with others but after 10 hours it clearly showed a
reverse correlation.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
None to above
Reviewer's report
Title:Cerebral microdialysis reflects the efficacy of Fractionated Plasma
Separation and Adsorption treatment of acute liver failure earlier than intracranial
pressure - a controlled study in pigs
Version: 1Date:3 April 2013
Reviewer: chuansheng wang
Reviewer's report:
Major compulsory revisions:
1. Title is misleading/unclear. I think the key finding of this paper is that
microdialysis data correlated with reduction of ICPs (which is significant compare
to reference 4 and 5 ) and potentially can be used as an early marker for
reduction of cerebral edema during the management of ALF in a pig model.
However, the title implies that FPSA is an effective therapy for acute liver failure.
2. Please clarify reference 4 and 5 in the introduction since their results are
critical for the authors work. In the discussion, the authors need to address the
different findings between their work using animal model and the other studies
using human ALF patients.
3. The introduction needs to be expanded so that it is clear to us what has been
done and what lead to your current hypothesis.
4. please elaborate on the reverse correlation between ICP and glutamine level
after 10 hours since it was not mentioned in the discussion. The impression given
is that you study is consistent with others but after 10 hours it clearly showed a
reverse correlation.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
None to above
Please review this paper.
user
Reviewer's report
Title:Cerebral microdialysis reflects the efficacy of Fractionated Plasma
Separation and Adsorption treatment of acute liver failure earlier than intracranial
pressure - a controlled study in pigs
Version: 1Date:3 April 2013
Reviewer: chuansheng wang
Reviewer's report:
Major compulsory revisions:
1. Title is misleading/unclear. I think the key finding of this paper is that
microdialysis data correlated with reduction of ICPs (which is significant compare
to reference 4 and 5 ) and potentially can be used as an early marker for
reduction of cerebral edema during the management of ALF in a pig model.
However, the title implies that FPSA is an effective therapy for acute liver failure.
2. Please clarify reference 4 and 5 in the introduction since their results are
critical for the authors work. In the discussion, the authors need to address the
different findings between their work using animal model and the other studies
using human ALF patients.
3. The introduction needs to be expanded so that it is clear to us what has been
done and what lead to your current hypothesis.
4. please elaborate on the reverse correlation between ICP and glutamine level
after 10 hours since it was not mentioned in the discussion. The impression given
is that you study is consistent with others but after 10 hours it clearly showed a
reverse correlation.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
None to above
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