Reviewer's report
Title:Laxative effects of Salecan on loperamide-induced constipation in mice
Version: 2Date:7 December 2012
Reviewer: Juei-Tang Cheng
Reviewer's report:
Major Compulsory Revisions:
It shall be identified that Salecan is also effective on another animal model
showing constipation. Then, the conclusion will be reliable.
Minor Essential Revisions:
1. The source of Salecan is not clear. It is not a way to show according to
previous method only.
2. In reply of last comments, authors agreed that loperamide absorption is
possible to modify by Salecan. But this point was not included in this revision.
3. Formation of SCFAs is speculative only. But authors focused it too much.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Laxative effects of Salecan on loperamide-induced constipation in mice
Version: 2Date:7 December 2012
Reviewer: Juei-Tang Cheng
Reviewer's report:
Major Compulsory Revisions:
It shall be identified that Salecan is also effective on another animal model
showing constipation. Then, the conclusion will be reliable.
Minor Essential Revisions:
1. The source of Salecan is not clear. It is not a way to show according to
previous method only.
2. In reply of last comments, authors agreed that loperamide absorption is
possible to modify by Salecan. But this point was not included in this revision.
3. Formation of SCFAs is speculative only. But authors focused it too much.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Laxative effects of Salecan on loperamide-induced constipation in mice
Version: 2Date:7 December 2012
Reviewer: Juei-Tang Cheng
Reviewer's report:
Major Compulsory Revisions:
It shall be identified that Salecan is also effective on another animal model
showing constipation. Then, the conclusion will be reliable.
Minor Essential Revisions:
1. The source of Salecan is not clear. It is not a way to show according to
previous method only.
2. In reply of last comments, authors agreed that loperamide absorption is
possible to modify by Salecan. But this point was not included in this revision.
3. Formation of SCFAs is speculative only. But authors focused it too much.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant