Title: Title: Immediate postoperative parenteral anticoagulant therapy in patients with
mesenteric ischemia after intestinal resection – A retrospective cohort study at a single institute.
Version: 3 Date: 22 Apr 2022
Reviewer:  Ahmed Kamel Abdulhamid
Reviewer's report:
My Comments:
1-Title and abstract:
If the study used enoxaprin only , then I think in the title the author must use the word enoxaparin
instead of anticoagulants. This can make the study more significant and unique. The term anti-
coagulant is very wide
In addition, the author should add their findings to the title (improve prognosis)
So I think the title must be:
Title: Immediate postoperative parenteral enoxaparin in the patients with mesenteric infarction
after intestine resection can improve the prognosis significantly – a retrospective cohort research
in a single institute.
However, I can see that in abstract the authors said that they used enoxaparin only. But in the
result section they said that enoxaparin and heparin were used. So this discrepancy must be
corrected
2-Method and result sections:
Regarding group B: the authors should explain what they mean by immediate post-op exactly.
Is it minutes post-op? how many minutes? Or is it hours post op? how many hours?
Regarding group A: have they not received post op enoxaparin at all? Or have they received
enoxaprin post op but it was not immediate? If this is the case, then authors again should explain
when it was exactly? was it days post op? if yes, how many days?
I can see (in result section) that anti-platelets and heparin were used as well (not only enoxaparin
as was mentioned in abstract). I think that the comparison must be specific such as anti-platelet
versus non anti-platelets or anti-coagulant versus non anti-coagulants
In addition, in order to show the pure effect of anti-coagulants, other variables must be nearly
similar. In other words, the authors must compare between group A and group B in terms of effect
of post op anti-coagulants only. This means that other variables (between group A and B) must
be nearly similar.  Such as the extent of bowel gangrene , the cause of this gangrene, the exact
finding on gross and microscopic pathological examination, surgery used, surgeon experience,
duration of surgery, time taken before presentation , time taken for diagnosis, patient's factors
such as age, past medical history, co-morbidities, past surgical history, drug history and the
degree of patho-physiological disturbance at time of presentation. The authors must explain all
these findings and whether they were nearly similar or not
3-Discussion and conclusion section
-There is no need to explain the mechanism of action anti-coagulants and anti-platelets
-The authors should try to explain the potential reasons of their results
-The authors must compare their study with other studies
Title: Title: Immediate postoperative parenteral anticoagulant therapy in patients with
mesenteric ischemia after intestinal resection – A retrospective cohort study at a single institute.
Version: 3 Date: 22 Apr 2022
Reviewer:  Ahmed Kamel Abdulhamid
Reviewer's report:
My Comments:
1-Title and abstract:
If the study used enoxaprin only , then I think in the title the author must use the word enoxaparin
instead of anticoagulants. This can make the study more significant and unique. The term anti-
coagulant is very wide
In addition, the author should add their findings to the title (improve prognosis)
So I think the title must be:
Title: Immediate postoperative parenteral enoxaparin in the patients with mesenteric infarction
after intestine resection can improve the prognosis significantly – a retrospective cohort research
in a single institute.
However, I can see that in abstract the authors said that they used enoxaparin only. But in the
result section they said that enoxaparin and heparin were used. So this discrepancy must be
corrected
2-Method and result sections:
Regarding group B: the authors should explain what they mean by immediate post-op exactly.
Is it minutes post-op? how many minutes? Or is it hours post op? how many hours?
Regarding group A: have they not received post op enoxaparin at all? Or have they received
enoxaprin post op but it was not immediate? If this is the case, then authors again should explain
when it was exactly? was it days post op? if yes, how many days?
I can see (in result section) that anti-platelets and heparin were used as well (not only enoxaparin
as was mentioned in abstract). I think that the comparison must be specific such as anti-platelet
versus non anti-platelets or anti-coagulant versus non anti-coagulants
In addition, in order to show the pure effect of anti-coagulants, other variables must be nearly
similar. In other words, the authors must compare between group A and group B in terms of effect
of post op anti-coagulants only. This means that other variables (between group A and B) must
be nearly similar.  Such as the extent of bowel gangrene , the cause of this gangrene, the exact
finding on gross and microscopic pathological examination, surgery used, surgeon experience,
duration of surgery, time taken before presentation , time taken for diagnosis, patient's factors
such as age, past medical history, co-morbidities, past surgical history, drug history and the
degree of patho-physiological disturbance at time of presentation. The authors must explain all
these findings and whether they were nearly similar or not
3-Discussion and conclusion section
-There is no need to explain the mechanism of action anti-coagulants and anti-platelets
-The authors should try to explain the potential reasons of their results
-The authors must compare their study with other studies
Please review this paper.
user
Title: Title: Immediate postoperative parenteral anticoagulant therapy in patients with
mesenteric ischemia after intestinal resection – A retrospective cohort study at a single institute.
Version: 3 Date: 22 Apr 2022
Reviewer:  Ahmed Kamel Abdulhamid
Reviewer's report:
My Comments:
1-Title and abstract:
If the study used enoxaprin only , then I think in the title the author must use the word enoxaparin
instead of anticoagulants. This can make the study more significant and unique. The term anti-
coagulant is very wide
In addition, the author should add their findings to the title (improve prognosis)
So I think the title must be:
Title: Immediate postoperative parenteral enoxaparin in the patients with mesenteric infarction
after intestine resection can improve the prognosis significantly – a retrospective cohort research
in a single institute.
However, I can see that in abstract the authors said that they used enoxaparin only. But in the
result section they said that enoxaparin and heparin were used. So this discrepancy must be
corrected
2-Method and result sections:
Regarding group B: the authors should explain what they mean by immediate post-op exactly.
Is it minutes post-op? how many minutes? Or is it hours post op? how many hours?
Regarding group A: have they not received post op enoxaparin at all? Or have they received
enoxaprin post op but it was not immediate? If this is the case, then authors again should explain
when it was exactly? was it days post op? if yes, how many days?
I can see (in result section) that anti-platelets and heparin were used as well (not only enoxaparin
as was mentioned in abstract). I think that the comparison must be specific such as anti-platelet
versus non anti-platelets or anti-coagulant versus non anti-coagulants
In addition, in order to show the pure effect of anti-coagulants, other variables must be nearly
similar. In other words, the authors must compare between group A and group B in terms of effect
of post op anti-coagulants only. This means that other variables (between group A and B) must
be nearly similar.  Such as the extent of bowel gangrene , the cause of this gangrene, the exact
finding on gross and microscopic pathological examination, surgery used, surgeon experience,
duration of surgery, time taken before presentation , time taken for diagnosis, patient's factors
such as age, past medical history, co-morbidities, past surgical history, drug history and the
degree of patho-physiological disturbance at time of presentation. The authors must explain all
these findings and whether they were nearly similar or not
3-Discussion and conclusion section
-There is no need to explain the mechanism of action anti-coagulants and anti-platelets
-The authors should try to explain the potential reasons of their results
-The authors must compare their study with other studies
assistant