Title: Characteristics of acute kidney injury and its impact on outcome in patients with acute-
on-chronic liver failure
Version: 1 Date: 09 Apr 2022
Reviewer's report:
I appreciate the authors responses to comments made.
I still would highlight some issues though:
1. The abstract needs to be clearer about main objective and KP AKI model components.
2. HRS definition remains confusing: is it the old one (sCr cutoff of 1.5mg/dl without other
causes) or the new one (a specific type of AKI as per KDIGO guidelines)?
3. I think providing missing data across all variables and if imputation was performed for
modelling would be valuable.
4. Was there any collinear behaviour between liver function tests such as bilirubin, albumin and
PT?
5. I still feel a brier score, besides calibration plots, would be better to assess predictive power
of models in different sets.
6. Again, it would be informative to clearly provide how many patients developed sepsis or
needed RRT, ICU admission, and LT.
7. I think limitations section should be expanded, for example: selection bias (retrospective
nature), exclusion of CA AKI, HBV etiology preponderance, overall severity of disease or access
to LT.
8. Again, the manuscript is too long.
Title: Characteristics of acute kidney injury and its impact on outcome in patients with acute-
on-chronic liver failure
Version: 1 Date: 09 Apr 2022
Reviewer's report:
I appreciate the authors responses to comments made.
I still would highlight some issues though:
1. The abstract needs to be clearer about main objective and KP AKI model components.
2. HRS definition remains confusing: is it the old one (sCr cutoff of 1.5mg/dl without other
causes) or the new one (a specific type of AKI as per KDIGO guidelines)?
3. I think providing missing data across all variables and if imputation was performed for
modelling would be valuable.
4. Was there any collinear behaviour between liver function tests such as bilirubin, albumin and
PT?
5. I still feel a brier score, besides calibration plots, would be better to assess predictive power
of models in different sets.
6. Again, it would be informative to clearly provide how many patients developed sepsis or
needed RRT, ICU admission, and LT.
7. I think limitations section should be expanded, for example: selection bias (retrospective
nature), exclusion of CA AKI, HBV etiology preponderance, overall severity of disease or access
to LT.
8. Again, the manuscript is too long.
Please review this paper.
user
Title: Characteristics of acute kidney injury and its impact on outcome in patients with acute-
on-chronic liver failure
Version: 1 Date: 09 Apr 2022
Reviewer's report:
I appreciate the authors responses to comments made.
I still would highlight some issues though:
1. The abstract needs to be clearer about main objective and KP AKI model components.
2. HRS definition remains confusing: is it the old one (sCr cutoff of 1.5mg/dl without other
causes) or the new one (a specific type of AKI as per KDIGO guidelines)?
3. I think providing missing data across all variables and if imputation was performed for
modelling would be valuable.
4. Was there any collinear behaviour between liver function tests such as bilirubin, albumin and
PT?
5. I still feel a brier score, besides calibration plots, would be better to assess predictive power
of models in different sets.
6. Again, it would be informative to clearly provide how many patients developed sepsis or
needed RRT, ICU admission, and LT.
7. I think limitations section should be expanded, for example: selection bias (retrospective
nature), exclusion of CA AKI, HBV etiology preponderance, overall severity of disease or access
to LT.
8. Again, the manuscript is too long.
assistant