Title: The Efficacy of Retrograde and Antegrade Enemas in the Management of Low Anterior
Resection Syndrome in Patients Undergoing Rectal Resection: A Systematic Review and Meta-
analysis
Version: 2 Date: 22 Apr 2025
Reviewer's report:
Thank you very much for detailed comments. Please provide authors detailed justification on
the RoB conclusions.
I believe that including in the intervention arm studies that used enema for prophylactic and
treatment purposes is inappropriate. To reduce heterogeneity you should either include studies
that were used for prevention of LARS or cure of LARS, not both.
My impression, in this form, this study will have a better sound if published as a systematic
review only.
Title: The Efficacy of Retrograde and Antegrade Enemas in the Management of Low Anterior
Resection Syndrome in Patients Undergoing Rectal Resection: A Systematic Review and Meta-
analysis
Version: 2 Date: 22 Apr 2025
Reviewer's report:
Thank you very much for detailed comments. Please provide authors detailed justification on
the RoB conclusions.
I believe that including in the intervention arm studies that used enema for prophylactic and
treatment purposes is inappropriate. To reduce heterogeneity you should either include studies
that were used for prevention of LARS or cure of LARS, not both.
My impression, in this form, this study will have a better sound if published as a systematic
review only.
Please review this paper.
user
Title: The Efficacy of Retrograde and Antegrade Enemas in the Management of Low Anterior
Resection Syndrome in Patients Undergoing Rectal Resection: A Systematic Review and Meta-
analysis
Version: 2 Date: 22 Apr 2025
Reviewer's report:
Thank you very much for detailed comments. Please provide authors detailed justification on
the RoB conclusions.
I believe that including in the intervention arm studies that used enema for prophylactic and
treatment purposes is inappropriate. To reduce heterogeneity you should either include studies
that were used for prevention of LARS or cure of LARS, not both.
My impression, in this form, this study will have a better sound if published as a systematic
review only.
assistant