Title: Clinical and Microbiological Profile of Patients with Diarrhea Evaluated Using the
Gastrointestinal Panel in a High-Complexity Center
Version: 3 Date: 10 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Was response to treatment taken into consideration to evaluate the method ? What
authors mean by inflammatory diarrhea? By which method has it  been diagnosed? Why
treatment was given empirically while there was a result from stool?Those questions are valid
for methods section as well Methods Definitions of acute, persistent and chronic diarrhea
should be provided Demographic and clinical parameters recorded should be descibed  Were
there any additional exclusion criteria apart from age like clinical condition, inability to
provide medical history, metal illnesses? Statistics Would multivariated analysis be useful ?
Results SD should be provided apart from mean Was population homogenious comparing their
dwelling? In patients with C.Difficile , had authors proceeded to treatment without checking
for toxins in stool? Was there any diffrence between in-patients and out-patients? Was there
any difference between inflammatory and non-inflammatory diarrhea? Was there any diffrence
between immucompetent and immunosuppressed patients in identifing more than one organism?
Title: Clinical and Microbiological Profile of Patients with Diarrhea Evaluated Using the
Gastrointestinal Panel in a High-Complexity Center
Version: 3 Date: 10 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Was response to treatment taken into consideration to evaluate the method ? What
authors mean by inflammatory diarrhea? By which method has it  been diagnosed? Why
treatment was given empirically while there was a result from stool?Those questions are valid
for methods section as well Methods Definitions of acute, persistent and chronic diarrhea
should be provided Demographic and clinical parameters recorded should be descibed  Were
there any additional exclusion criteria apart from age like clinical condition, inability to
provide medical history, metal illnesses? Statistics Would multivariated analysis be useful ?
Results SD should be provided apart from mean Was population homogenious comparing their
dwelling? In patients with C.Difficile , had authors proceeded to treatment without checking
for toxins in stool? Was there any diffrence between in-patients and out-patients? Was there
any difference between inflammatory and non-inflammatory diarrhea? Was there any diffrence
between immucompetent and immunosuppressed patients in identifing more than one organism?
Please review this paper.
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Title: Clinical and Microbiological Profile of Patients with Diarrhea Evaluated Using the
Gastrointestinal Panel in a High-Complexity Center
Version: 3 Date: 10 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Was response to treatment taken into consideration to evaluate the method ? What
authors mean by inflammatory diarrhea? By which method has it  been diagnosed? Why
treatment was given empirically while there was a result from stool?Those questions are valid
for methods section as well Methods Definitions of acute, persistent and chronic diarrhea
should be provided Demographic and clinical parameters recorded should be descibed  Were
there any additional exclusion criteria apart from age like clinical condition, inability to
provide medical history, metal illnesses? Statistics Would multivariated analysis be useful ?
Results SD should be provided apart from mean Was population homogenious comparing their
dwelling? In patients with C.Difficile , had authors proceeded to treatment without checking
for toxins in stool? Was there any diffrence between in-patients and out-patients? Was there
any difference between inflammatory and non-inflammatory diarrhea? Was there any diffrence
between immucompetent and immunosuppressed patients in identifing more than one organism?
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