Title: Accuracy of the diagnosis of gastroesophageal reflux disease by a trial of potassium-
competitive acid blocker treatment
Version: 2 Date: 15 Apr 2025
Reviewer's report:
This study investigated the accuracy of the P CAB diagnostic test for the diagnosis of GERD.
In this study, tegoprazan had a diagnostic sensitivity of 77.5% and specificity of 51.9%,  for
the diagnosis of GERD, using a 75% symptom improvement rate at 1 week after administration
as the diagnostic cutoff.  The P CAB responsiveness was compared endoscopy and pH
testing. Diagnostic sensitivity and specificity is better than previously reported accuracy of PPI
diagnostic tests
Minor comments
In this study, there were 4 patients with LA A erosive esophagitis among the patients categorized
as non-GERD. In the Lyon diagnostic criteria, LA A erosive esophagitis is not conclusive
evidence but inconclusive (borderline) evidence. Therefore, we cannot say with certainty that it
is not GERD. Would the results change if these four patients were excluded?
Excluding patients with Borderline GERD would improve diagnostic accuracy What are your
thoughts on this?
Title: Accuracy of the diagnosis of gastroesophageal reflux disease by a trial of potassium-
competitive acid blocker treatment
Version: 2 Date: 15 Apr 2025
Reviewer's report:
This study investigated the accuracy of the P CAB diagnostic test for the diagnosis of GERD.
In this study, tegoprazan had a diagnostic sensitivity of 77.5% and specificity of 51.9%,  for
the diagnosis of GERD, using a 75% symptom improvement rate at 1 week after administration
as the diagnostic cutoff.  The P CAB responsiveness was compared endoscopy and pH
testing. Diagnostic sensitivity and specificity is better than previously reported accuracy of PPI
diagnostic tests
Minor comments
In this study, there were 4 patients with LA A erosive esophagitis among the patients categorized
as non-GERD. In the Lyon diagnostic criteria, LA A erosive esophagitis is not conclusive
evidence but inconclusive (borderline) evidence. Therefore, we cannot say with certainty that it
is not GERD. Would the results change if these four patients were excluded?
Excluding patients with Borderline GERD would improve diagnostic accuracy What are your
thoughts on this?
Please review this paper.
user
Title: Accuracy of the diagnosis of gastroesophageal reflux disease by a trial of potassium-
competitive acid blocker treatment
Version: 2 Date: 15 Apr 2025
Reviewer's report:
This study investigated the accuracy of the P CAB diagnostic test for the diagnosis of GERD.
In this study, tegoprazan had a diagnostic sensitivity of 77.5% and specificity of 51.9%,  for
the diagnosis of GERD, using a 75% symptom improvement rate at 1 week after administration
as the diagnostic cutoff.  The P CAB responsiveness was compared endoscopy and pH
testing. Diagnostic sensitivity and specificity is better than previously reported accuracy of PPI
diagnostic tests
Minor comments
In this study, there were 4 patients with LA A erosive esophagitis among the patients categorized
as non-GERD. In the Lyon diagnostic criteria, LA A erosive esophagitis is not conclusive
evidence but inconclusive (borderline) evidence. Therefore, we cannot say with certainty that it
is not GERD. Would the results change if these four patients were excluded?
Excluding patients with Borderline GERD would improve diagnostic accuracy What are your
thoughts on this?
assistant