Reviewer's report
Title:Early stage transplantation of bone marrow cells markedly ameliorates
copper metabolism and liver function in Wilson disease mice
Version: 2Date:31 December 2010
Reviewer: Nicole Buck
Reviewer's report:
They have added some new data to the manuscript, however they were
obviously unable to do more experimental work to complete the project. The
authors have however done a significant amount of work which is scientifically
sound, but are missing some controls which they plan on rectifying in future
experiments. Some of the conclusions are broad and do not take into account
non-hepatic sites.
The methods section is now more descriptive, however could the authors add the
details of the DNA extraction kit?
My major concern is still the statistical analysis. They have overlapping error
bars; however they claim the results are significantly different.
The English is also still a major problem.
For example,
1. The Abstract background section (second sentence) makes no sense to me.
2. Orthotropic should be orthotopic (spelling)
3. "BM cells" abbreviation should be checked for context to correct the use of
"cell" or "cells"
4. Ref #14 should be Allen not Allan.
etc
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Early stage transplantation of bone marrow cells markedly ameliorates
copper metabolism and liver function in Wilson disease mice
Version: 2Date:31 December 2010
Reviewer: Nicole Buck
Reviewer's report:
They have added some new data to the manuscript, however they were
obviously unable to do more experimental work to complete the project. The
authors have however done a significant amount of work which is scientifically
sound, but are missing some controls which they plan on rectifying in future
experiments. Some of the conclusions are broad and do not take into account
non-hepatic sites.
The methods section is now more descriptive, however could the authors add the
details of the DNA extraction kit?
My major concern is still the statistical analysis. They have overlapping error
bars; however they claim the results are significantly different.
The English is also still a major problem.
For example,
1. The Abstract background section (second sentence) makes no sense to me.
2. Orthotropic should be orthotopic (spelling)
3. "BM cells" abbreviation should be checked for context to correct the use of
"cell" or "cells"
4. Ref #14 should be Allen not Allan.
etc
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Early stage transplantation of bone marrow cells markedly ameliorates
copper metabolism and liver function in Wilson disease mice
Version: 2Date:31 December 2010
Reviewer: Nicole Buck
Reviewer's report:
They have added some new data to the manuscript, however they were
obviously unable to do more experimental work to complete the project. The
authors have however done a significant amount of work which is scientifically
sound, but are missing some controls which they plan on rectifying in future
experiments. Some of the conclusions are broad and do not take into account
non-hepatic sites.
The methods section is now more descriptive, however could the authors add the
details of the DNA extraction kit?
My major concern is still the statistical analysis. They have overlapping error
bars; however they claim the results are significantly different.
The English is also still a major problem.
For example,
1. The Abstract background section (second sentence) makes no sense to me.
2. Orthotropic should be orthotopic (spelling)
3. "BM cells" abbreviation should be checked for context to correct the use of
"cell" or "cells"
4. Ref #14 should be Allen not Allan.
etc
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
assistant