Title: Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study
using a national inpatient database
Version: 2 Date: 28 Mar 2023
Reviewer's report:
To authors
In this study, author investigated the real world data of HRS in Japan. They found that albumin
and dopamine was more frequently used for patients with HRS. This paper is interesting but
there are a few problems with the manuscript.
1. Male, length of hospital stay, CP score, and HCC are associated with death or liver
transplantation. These factors except for male are reasonable. Please explain or discuss the
reason for male.
2. Tolvaptan is used for liver disease only in Japan. Please discussed this issue.
Title: Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study
using a national inpatient database
Version: 2 Date: 28 Mar 2023
Reviewer's report:
To authors
In this study, author investigated the real world data of HRS in Japan. They found that albumin
and dopamine was more frequently used for patients with HRS. This paper is interesting but
there are a few problems with the manuscript.
1. Male, length of hospital stay, CP score, and HCC are associated with death or liver
transplantation. These factors except for male are reasonable. Please explain or discuss the
reason for male.
2. Tolvaptan is used for liver disease only in Japan. Please discussed this issue.
Please review this paper.
user
Title: Treatment and outcome of hepatorenal syndrome in Japan: A retrospective cohort study
using a national inpatient database
Version: 2 Date: 28 Mar 2023
Reviewer's report:
To authors
In this study, author investigated the real world data of HRS in Japan. They found that albumin
and dopamine was more frequently used for patients with HRS. This paper is interesting but
there are a few problems with the manuscript.
1. Male, length of hospital stay, CP score, and HCC are associated with death or liver
transplantation. These factors except for male are reasonable. Please explain or discuss the
reason for male.
2. Tolvaptan is used for liver disease only in Japan. Please discussed this issue.
assistant