Reviewer's report
Title:Rapid Induction of Orthotopic Hepatocellular Carcinoma in
Immune-competent Rats by Ultrasound-guided Method and the Subsequent
Low-dose Chemotherapy
Version: 3Date:30 June 2010
Reviewer: Urban Emmenegger
Reviewer's report:
The concerns raised have been addressed in sufficient manner. A few minor
revisions can be made by the authors without the need for another round of
reviewing.
(1) page 9: 900 mg/sqm of epirubicin corresponds to approximately 300 mg/kg of
epirubicin in mice, using a commonly applied conversion factor of 3. This should
be corrected.
(2) page 13: the authors may want to indicate the formula used for calculation of
tumor volumes.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Rapid Induction of Orthotopic Hepatocellular Carcinoma in
Immune-competent Rats by Ultrasound-guided Method and the Subsequent
Low-dose Chemotherapy
Version: 3Date:30 June 2010
Reviewer: Urban Emmenegger
Reviewer's report:
The concerns raised have been addressed in sufficient manner. A few minor
revisions can be made by the authors without the need for another round of
reviewing.
(1) page 9: 900 mg/sqm of epirubicin corresponds to approximately 300 mg/kg of
epirubicin in mice, using a commonly applied conversion factor of 3. This should
be corrected.
(2) page 13: the authors may want to indicate the formula used for calculation of
tumor volumes.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Rapid Induction of Orthotopic Hepatocellular Carcinoma in
Immune-competent Rats by Ultrasound-guided Method and the Subsequent
Low-dose Chemotherapy
Version: 3Date:30 June 2010
Reviewer: Urban Emmenegger
Reviewer's report:
The concerns raised have been addressed in sufficient manner. A few minor
revisions can be made by the authors without the need for another round of
reviewing.
(1) page 9: 900 mg/sqm of epirubicin corresponds to approximately 300 mg/kg of
epirubicin in mice, using a commonly applied conversion factor of 3. This should
be corrected.
(2) page 13: the authors may want to indicate the formula used for calculation of
tumor volumes.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant