Reviewer's report
Title:Time Esophageal pH<4 Overestimates the Prevalence of Pathologic
Esophageal Reflux in Subjects with Gastroesophageal Reflux Disease Treated
with Proton Pump Inhibitors
Version: 2Date:1 February 2008
Reviewer: Martin Fein
Reviewer's report:
Major compulsory revisions
1. The basis for the paper is the analysis of gastric integrated acidity. Therefore,
it is necessary to explain this method briefly.
2. The authors have observed that the prevalence of pathologic esophageal
reflux in patients treated with PPI is lower when measured by gastric integrated
acidity.
What are the consequences for the use of pH-monitoring? Which patients need
to have this analysis and what are possible consequences?
(needs to be added in the discussion to show the advance possible by using this
method)
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Time Esophageal pH<4 Overestimates the Prevalence of Pathologic
Esophageal Reflux in Subjects with Gastroesophageal Reflux Disease Treated
with Proton Pump Inhibitors
Version: 2Date:1 February 2008
Reviewer: Martin Fein
Reviewer's report:
Major compulsory revisions
1. The basis for the paper is the analysis of gastric integrated acidity. Therefore,
it is necessary to explain this method briefly.
2. The authors have observed that the prevalence of pathologic esophageal
reflux in patients treated with PPI is lower when measured by gastric integrated
acidity.
What are the consequences for the use of pH-monitoring? Which patients need
to have this analysis and what are possible consequences?
(needs to be added in the discussion to show the advance possible by using this
method)
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Time Esophageal pH<4 Overestimates the Prevalence of Pathologic
Esophageal Reflux in Subjects with Gastroesophageal Reflux Disease Treated
with Proton Pump Inhibitors
Version: 2Date:1 February 2008
Reviewer: Martin Fein
Reviewer's report:
Major compulsory revisions
1. The basis for the paper is the analysis of gastric integrated acidity. Therefore,
it is necessary to explain this method briefly.
2. The authors have observed that the prevalence of pathologic esophageal
reflux in patients treated with PPI is lower when measured by gastric integrated
acidity.
What are the consequences for the use of pH-monitoring? Which patients need
to have this analysis and what are possible consequences?
(needs to be added in the discussion to show the advance possible by using this
method)
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant