Title: The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in
alcohol-related liver disease: A cohort study.
Version: 1 Date: 08 Feb 2021
Reviewer's report:
This is an interesting observational cohort study related to The Enhanced Liver Fibrosis (ELF)
test as a serological biomarker for fibrosis staging and as a prognostic factor in alcohol related
liver diseases.
The paper is interesting but needs some changes from my point of view.
786 tertiary care patients with alcohol-related liver disease due to alcohol (n=81) and non-
alcohol aetiologies (n = 705) – this sentence is a little confusing, please rephrase.
The Enhanced Liver Fibrosis (ELF) test is a non-invasive test that combines measurements of
three markers of hepatic extracellular matrix to generate a unitless numerical score.(11) – the
markers should be specified, especially since you have them at abbreviation. Please insert them
also in the text. References should be placed before the point from the sentence end everywhere
in the text.
ELF performs well as a diagnostic test for fibrosis – it is not a diagnostic test, but it is a non-
invasive test that estimates liver fibrosis. Please rephrase.
Although concern exists that ongoing alcohol consumption may affect the levels of individual
ELF constituents, a recent study validated the use of ELF in detecting significant and advanced
fibrosis and cirrhosis in ARLD.(13, 18) – reference 13 is related to this, reference 18 should be
placed before comma since is related to the first part of the sentence.
Setting: Secondary care – in the abstract it is presented that the study was performed in tertiary
care centres?
Conclusion: We found that ELF performed well as both a diagnostic and prognostic marker of
fibrosis severity in ARLD – the test can not be used for diagnosis of any stage of fibrosis so you
should specify in conclusion that performed well for staging moderate and advanced fibrosis.
Title: The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in
alcohol-related liver disease: A cohort study.
Version: 1 Date: 08 Feb 2021
Reviewer's report:
This is an interesting observational cohort study related to The Enhanced Liver Fibrosis (ELF)
test as a serological biomarker for fibrosis staging and as a prognostic factor in alcohol related
liver diseases.
The paper is interesting but needs some changes from my point of view.
786 tertiary care patients with alcohol-related liver disease due to alcohol (n=81) and non-
alcohol aetiologies (n = 705) – this sentence is a little confusing, please rephrase.
The Enhanced Liver Fibrosis (ELF) test is a non-invasive test that combines measurements of
three markers of hepatic extracellular matrix to generate a unitless numerical score.(11) – the
markers should be specified, especially since you have them at abbreviation. Please insert them
also in the text. References should be placed before the point from the sentence end everywhere
in the text.
ELF performs well as a diagnostic test for fibrosis – it is not a diagnostic test, but it is a non-
invasive test that estimates liver fibrosis. Please rephrase.
Although concern exists that ongoing alcohol consumption may affect the levels of individual
ELF constituents, a recent study validated the use of ELF in detecting significant and advanced
fibrosis and cirrhosis in ARLD.(13, 18) – reference 13 is related to this, reference 18 should be
placed before comma since is related to the first part of the sentence.
Setting: Secondary care – in the abstract it is presented that the study was performed in tertiary
care centres?
Conclusion: We found that ELF performed well as both a diagnostic and prognostic marker of
fibrosis severity in ARLD – the test can not be used for diagnosis of any stage of fibrosis so you
should specify in conclusion that performed well for staging moderate and advanced fibrosis.
Please review this paper.
user
Title: The Enhanced Liver Fibrosis test maintains its diagnostic and prognostic performance in
alcohol-related liver disease: A cohort study.
Version: 1 Date: 08 Feb 2021
Reviewer's report:
This is an interesting observational cohort study related to The Enhanced Liver Fibrosis (ELF)
test as a serological biomarker for fibrosis staging and as a prognostic factor in alcohol related
liver diseases.
The paper is interesting but needs some changes from my point of view.
786 tertiary care patients with alcohol-related liver disease due to alcohol (n=81) and non-
alcohol aetiologies (n = 705) – this sentence is a little confusing, please rephrase.
The Enhanced Liver Fibrosis (ELF) test is a non-invasive test that combines measurements of
three markers of hepatic extracellular matrix to generate a unitless numerical score.(11) – the
markers should be specified, especially since you have them at abbreviation. Please insert them
also in the text. References should be placed before the point from the sentence end everywhere
in the text.
ELF performs well as a diagnostic test for fibrosis – it is not a diagnostic test, but it is a non-
invasive test that estimates liver fibrosis. Please rephrase.
Although concern exists that ongoing alcohol consumption may affect the levels of individual
ELF constituents, a recent study validated the use of ELF in detecting significant and advanced
fibrosis and cirrhosis in ARLD.(13, 18) – reference 13 is related to this, reference 18 should be
placed before comma since is related to the first part of the sentence.
Setting: Secondary care – in the abstract it is presented that the study was performed in tertiary
care centres?
Conclusion: We found that ELF performed well as both a diagnostic and prognostic marker of
fibrosis severity in ARLD – the test can not be used for diagnosis of any stage of fibrosis so you
should specify in conclusion that performed well for staging moderate and advanced fibrosis.
assistant