Title: Persistence of Anemia in patients with Celiac Disease despite a Gluten Free Diet: A
retrospective study
Version: 4 Date: 24 Oct 2024
Reviewer:  Juha Taavela
Reviewer's report:
Here are my comments regarding the manuscript by Valvano et al. entitled "Persistence of
Anemia in Celiac Disease patients despite a Gluten Free Diet: A retrospective study "
The paper presents a clear question and has nice findings overall. Somw I have some comments:
1. you present that celiac disease serology was done but I do not find what the values where
in follow-up?
2. Some of the references are not good, suggestions:
prevalence numbers are somewhere between 1.6 to 2.4 and you have nice new data from Italy
and other large european studies, use these:
https://www.sciencedirect.com/science/article/pii/S1590865822008714
and
https://onlinelibrary.wiley.com/doi/full/10.1111/apt.17803
In large population analyses the anemia, iron and folate are correlated to the activity
parameters and should be mentioned, comment according to your findings the following: https://
www.cghjournal.org/article/S1542-3565(12)01156-1/fulltext
anemia in pediatric celiac disease:
https://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000001221
anemia persists in adults:
https://onlinelibrary.wiley.com/doi/10.1111/joim.13548
3. Figures are poorly explained and not self-explananatory, please elaborate and remove
unnecessary abbrevations. X and y axles are not explained.
Title: Persistence of Anemia in patients with Celiac Disease despite a Gluten Free Diet: A
retrospective study
Version: 4 Date: 24 Oct 2024
Reviewer:  Juha Taavela
Reviewer's report:
Here are my comments regarding the manuscript by Valvano et al. entitled "Persistence of
Anemia in Celiac Disease patients despite a Gluten Free Diet: A retrospective study "
The paper presents a clear question and has nice findings overall. Somw I have some comments:
1. you present that celiac disease serology was done but I do not find what the values where
in follow-up?
2. Some of the references are not good, suggestions:
prevalence numbers are somewhere between 1.6 to 2.4 and you have nice new data from Italy
and other large european studies, use these:
https://www.sciencedirect.com/science/article/pii/S1590865822008714
and
https://onlinelibrary.wiley.com/doi/full/10.1111/apt.17803
In large population analyses the anemia, iron and folate are correlated to the activity
parameters and should be mentioned, comment according to your findings the following: https://
www.cghjournal.org/article/S1542-3565(12)01156-1/fulltext
anemia in pediatric celiac disease:
https://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000001221
anemia persists in adults:
https://onlinelibrary.wiley.com/doi/10.1111/joim.13548
3. Figures are poorly explained and not self-explananatory, please elaborate and remove
unnecessary abbrevations. X and y axles are not explained.
Please review this paper.
user
Title: Persistence of Anemia in patients with Celiac Disease despite a Gluten Free Diet: A
retrospective study
Version: 4 Date: 24 Oct 2024
Reviewer:  Juha Taavela
Reviewer's report:
Here are my comments regarding the manuscript by Valvano et al. entitled "Persistence of
Anemia in Celiac Disease patients despite a Gluten Free Diet: A retrospective study "
The paper presents a clear question and has nice findings overall. Somw I have some comments:
1. you present that celiac disease serology was done but I do not find what the values where
in follow-up?
2. Some of the references are not good, suggestions:
prevalence numbers are somewhere between 1.6 to 2.4 and you have nice new data from Italy
and other large european studies, use these:
https://www.sciencedirect.com/science/article/pii/S1590865822008714
and
https://onlinelibrary.wiley.com/doi/full/10.1111/apt.17803
In large population analyses the anemia, iron and folate are correlated to the activity
parameters and should be mentioned, comment according to your findings the following: https://
www.cghjournal.org/article/S1542-3565(12)01156-1/fulltext
anemia in pediatric celiac disease:
https://onlinelibrary.wiley.com/doi/10.1097/MPG.0000000000001221
anemia persists in adults:
https://onlinelibrary.wiley.com/doi/10.1111/joim.13548
3. Figures are poorly explained and not self-explananatory, please elaborate and remove
unnecessary abbrevations. X and y axles are not explained.
assistant