Title: Low-residue diet with oral nutritional supplements prior to colonoscopy improves the
quality of bowel preparation: an endoscopist-blinded, randomized controlled trial
Version: 0 Date: 31 Dec 2024
Reviewer's report:
Thank you for allowing me to review your article on the effectiveness of a low-residue diet with
oral nutritional supplements in bowel preparation for colonoscopy. Although I found this topic
interesting, more information is needed when considering publication.
Major Comments:
Patient acceptance or tolerance is another important factor for bowel preparation. It is a concern
whether ONS was acceptable for patients as a bowel preparation. The authors should at
least comment on this. Do you have information regarding this? Additionally, how about the
compliance of intake for ONS? Did every patient consume the entire amount of ONS?
The indication for colonoscopy must be explained. Otherwise, it is difficult to compare bowel
cleanliness, ADR, and PDR between the two groups.
Please provide the actual volume of PEG solution taken in both groups. Did every patient
consume a total of 3L PEG?
Please provide the cecal insertion time and withdrawal time for colonoscopy. These are also
important when evaluating the quality of bowel preparation.
Minor Comments:
A history of CRC was excluded according to your exclusion criteria, but 18% of the patients in
both groups had a history of abdominal surgery. Is this correct?
Could you provide the actual BBPS and OBPS scores? It would also be helpful for readers to
see the scores for each segment (right, transverse, and left colon).
P5, Lines 103-105: "To achieve a power of 95% and a significance level of 0.05, we calculated
that we would need approximately 81 participants per group to detect a meaningful difference
in cleanliness." What do you mean by "a meaningful difference in cleanliness"? Please explain
clearly how you calculated the sample size.
Title: Low-residue diet with oral nutritional supplements prior to colonoscopy improves the
quality of bowel preparation: an endoscopist-blinded, randomized controlled trial
Version: 0 Date: 31 Dec 2024
Reviewer's report:
Thank you for allowing me to review your article on the effectiveness of a low-residue diet with
oral nutritional supplements in bowel preparation for colonoscopy. Although I found this topic
interesting, more information is needed when considering publication.
Major Comments:
Patient acceptance or tolerance is another important factor for bowel preparation. It is a concern
whether ONS was acceptable for patients as a bowel preparation. The authors should at
least comment on this. Do you have information regarding this? Additionally, how about the
compliance of intake for ONS? Did every patient consume the entire amount of ONS?
The indication for colonoscopy must be explained. Otherwise, it is difficult to compare bowel
cleanliness, ADR, and PDR between the two groups.
Please provide the actual volume of PEG solution taken in both groups. Did every patient
consume a total of 3L PEG?
Please provide the cecal insertion time and withdrawal time for colonoscopy. These are also
important when evaluating the quality of bowel preparation.
Minor Comments:
A history of CRC was excluded according to your exclusion criteria, but 18% of the patients in
both groups had a history of abdominal surgery. Is this correct?
Could you provide the actual BBPS and OBPS scores? It would also be helpful for readers to
see the scores for each segment (right, transverse, and left colon).
P5, Lines 103-105: "To achieve a power of 95% and a significance level of 0.05, we calculated
that we would need approximately 81 participants per group to detect a meaningful difference
in cleanliness." What do you mean by "a meaningful difference in cleanliness"? Please explain
clearly how you calculated the sample size.
Please review this paper.
user
Title: Low-residue diet with oral nutritional supplements prior to colonoscopy improves the
quality of bowel preparation: an endoscopist-blinded, randomized controlled trial
Version: 0 Date: 31 Dec 2024
Reviewer's report:
Thank you for allowing me to review your article on the effectiveness of a low-residue diet with
oral nutritional supplements in bowel preparation for colonoscopy. Although I found this topic
interesting, more information is needed when considering publication.
Major Comments:
Patient acceptance or tolerance is another important factor for bowel preparation. It is a concern
whether ONS was acceptable for patients as a bowel preparation. The authors should at
least comment on this. Do you have information regarding this? Additionally, how about the
compliance of intake for ONS? Did every patient consume the entire amount of ONS?
The indication for colonoscopy must be explained. Otherwise, it is difficult to compare bowel
cleanliness, ADR, and PDR between the two groups.
Please provide the actual volume of PEG solution taken in both groups. Did every patient
consume a total of 3L PEG?
Please provide the cecal insertion time and withdrawal time for colonoscopy. These are also
important when evaluating the quality of bowel preparation.
Minor Comments:
A history of CRC was excluded according to your exclusion criteria, but 18% of the patients in
both groups had a history of abdominal surgery. Is this correct?
Could you provide the actual BBPS and OBPS scores? It would also be helpful for readers to
see the scores for each segment (right, transverse, and left colon).
P5, Lines 103-105: "To achieve a power of 95% and a significance level of 0.05, we calculated
that we would need approximately 81 participants per group to detect a meaningful difference
in cleanliness." What do you mean by "a meaningful difference in cleanliness"? Please explain
clearly how you calculated the sample size.
assistant