Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 4 Date: 19 May 2025
Reviewer's report:
The authors must be complemented for this well conducted review and for their decision to
restrict the inclusion criteria to rectal cancer. The discussion is relevant for different patient
groups and helps with informed consent with respect to timing of closure of the ileostomy.
The review acknowledges the paucity of data and recommends caution when undertaking early
closure and appears very relevant to surgeons and patients.
Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 4 Date: 19 May 2025
Reviewer's report:
The authors must be complemented for this well conducted review and for their decision to
restrict the inclusion criteria to rectal cancer. The discussion is relevant for different patient
groups and helps with informed consent with respect to timing of closure of the ileostomy.
The review acknowledges the paucity of data and recommends caution when undertaking early
closure and appears very relevant to surgeons and patients.
Please review this paper.
user
Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 4 Date: 19 May 2025
Reviewer's report:
The authors must be complemented for this well conducted review and for their decision to
restrict the inclusion criteria to rectal cancer. The discussion is relevant for different patient
groups and helps with informed consent with respect to timing of closure of the ileostomy.
The review acknowledges the paucity of data and recommends caution when undertaking early
closure and appears very relevant to surgeons and patients.
assistant