Title: The early biomarker of immature granulocyte count in predicting right-side colonic
complicated acute diverticulitis: A retrospective cohort study
Version: 2 Date: 03 Sep 2024
Reviewer's report:
The authors presents here a series of right-side colonic diverticulitis and searched for relevant
diagnostic biomarkers. They found immature granulocytes (IG) could be one of them. They
included 289 patients (31 complicated diverticulitis vs 258 uncomplicated).
They are several points to review :
- in the abstract, the authors should correct "left-side colonic" by "right-side" as they only
included right-side diverticulitis.
- the statistical analysis description should be reviewed because of some mistakes and missing
data. This manuscript reports diagnostic data about IG. The authors should follow the STARD
guidelines  so they must include likelihood ratio for example. The continue variables should be
presented as median (with interquartile range) or mean +/- standard deviation. The presentation
of binary data should include number (percentage).
Through the text, the decimal number should be less than 2. For the p values, if p = 0.000, you
should write <0.001. Because of these aspects the results are confusing.
For the regression, OR of SII is 1 so it is not a risk factor.
In the text the authors wrote "251 patients" in the uncomplicated group but in the flowchart it is
"258". Because of that, the authors should check their statistics through the text.
Title: The early biomarker of immature granulocyte count in predicting right-side colonic
complicated acute diverticulitis: A retrospective cohort study
Version: 2 Date: 03 Sep 2024
Reviewer's report:
The authors presents here a series of right-side colonic diverticulitis and searched for relevant
diagnostic biomarkers. They found immature granulocytes (IG) could be one of them. They
included 289 patients (31 complicated diverticulitis vs 258 uncomplicated).
They are several points to review :
- in the abstract, the authors should correct "left-side colonic" by "right-side" as they only
included right-side diverticulitis.
- the statistical analysis description should be reviewed because of some mistakes and missing
data. This manuscript reports diagnostic data about IG. The authors should follow the STARD
guidelines  so they must include likelihood ratio for example. The continue variables should be
presented as median (with interquartile range) or mean +/- standard deviation. The presentation
of binary data should include number (percentage).
Through the text, the decimal number should be less than 2. For the p values, if p = 0.000, you
should write <0.001. Because of these aspects the results are confusing.
For the regression, OR of SII is 1 so it is not a risk factor.
In the text the authors wrote "251 patients" in the uncomplicated group but in the flowchart it is
"258". Because of that, the authors should check their statistics through the text.
Please review this paper.
user
Title: The early biomarker of immature granulocyte count in predicting right-side colonic
complicated acute diverticulitis: A retrospective cohort study
Version: 2 Date: 03 Sep 2024
Reviewer's report:
The authors presents here a series of right-side colonic diverticulitis and searched for relevant
diagnostic biomarkers. They found immature granulocytes (IG) could be one of them. They
included 289 patients (31 complicated diverticulitis vs 258 uncomplicated).
They are several points to review :
- in the abstract, the authors should correct "left-side colonic" by "right-side" as they only
included right-side diverticulitis.
- the statistical analysis description should be reviewed because of some mistakes and missing
data. This manuscript reports diagnostic data about IG. The authors should follow the STARD
guidelines  so they must include likelihood ratio for example. The continue variables should be
presented as median (with interquartile range) or mean +/- standard deviation. The presentation
of binary data should include number (percentage).
Through the text, the decimal number should be less than 2. For the p values, if p = 0.000, you
should write <0.001. Because of these aspects the results are confusing.
For the regression, OR of SII is 1 so it is not a risk factor.
In the text the authors wrote "251 patients" in the uncomplicated group but in the flowchart it is
"258". Because of that, the authors should check their statistics through the text.
assistant