Title: Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative
gastric cancer patients: the FIESTA study
Version: 2 Date: 01 Aug 2022
Reviewer's report:
This is a prospective cohort study evaluating hypertension and diabetes as a risk of mortality in
gastric cancer patients based on a large n. Interesting results have been obtained. I would like
you to address a few points of concern.
1.   The authors wrote in "Mortality risk estimation" section, "As presented in Figure 2, Figure
3, and TableS3, after adjusting for age, gender, tobacco and alcohol As presented in Figure 2,
Figure 3, and TableS3, after adjusting for age, gender, tobacco and alcohol, and family history of
tumor, the overall mortality risk of patients with antihypertensive and hypoglycemic therapies
was lower by 42% (HR: 0.58, 95% CI: 0.47-0.73, p<0.001) and 70% (HR: 0.30, 95% CI:
0.24-0.38, p<0.001). Are the HRs in Figure 2 and 3 adjusted hazard ratios? Please explain in
detail how you estimated the HRs in Figures 2 and 3. It appears that the results of univariate
analysis are described as the results of multivariate analysis.
2. In the Survival comparison of medications, "(HR:0.33 compared to HR: 0.71 for Cox
regression and p:0.0152)" and "(HR:0.16 compared to HR: 0.86 for Cox regression, Log-rank
test p:0.0003). What does this mean? What does this mean? Please write the results correctly
so that the reader can understand the meaning correctly. The p-values are also mixed where the
logrank test is written and where it is not.
3. What is the classification of TableS2? Please describe the Characteristic correctly.
4. Please put Tick mark and No. at risk on all KaplanMeier curves.
Title: Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative
gastric cancer patients: the FIESTA study
Version: 2 Date: 01 Aug 2022
Reviewer's report:
This is a prospective cohort study evaluating hypertension and diabetes as a risk of mortality in
gastric cancer patients based on a large n. Interesting results have been obtained. I would like
you to address a few points of concern.
1.   The authors wrote in "Mortality risk estimation" section, "As presented in Figure 2, Figure
3, and TableS3, after adjusting for age, gender, tobacco and alcohol As presented in Figure 2,
Figure 3, and TableS3, after adjusting for age, gender, tobacco and alcohol, and family history of
tumor, the overall mortality risk of patients with antihypertensive and hypoglycemic therapies
was lower by 42% (HR: 0.58, 95% CI: 0.47-0.73, p<0.001) and 70% (HR: 0.30, 95% CI:
0.24-0.38, p<0.001). Are the HRs in Figure 2 and 3 adjusted hazard ratios? Please explain in
detail how you estimated the HRs in Figures 2 and 3. It appears that the results of univariate
analysis are described as the results of multivariate analysis.
2. In the Survival comparison of medications, "(HR:0.33 compared to HR: 0.71 for Cox
regression and p:0.0152)" and "(HR:0.16 compared to HR: 0.86 for Cox regression, Log-rank
test p:0.0003). What does this mean? What does this mean? Please write the results correctly
so that the reader can understand the meaning correctly. The p-values are also mixed where the
logrank test is written and where it is not.
3. What is the classification of TableS2? Please describe the Characteristic correctly.
4. Please put Tick mark and No. at risk on all KaplanMeier curves.
Please review this paper.
user
Title: Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative
gastric cancer patients: the FIESTA study
Version: 2 Date: 01 Aug 2022
Reviewer's report:
This is a prospective cohort study evaluating hypertension and diabetes as a risk of mortality in
gastric cancer patients based on a large n. Interesting results have been obtained. I would like
you to address a few points of concern.
1.   The authors wrote in "Mortality risk estimation" section, "As presented in Figure 2, Figure
3, and TableS3, after adjusting for age, gender, tobacco and alcohol As presented in Figure 2,
Figure 3, and TableS3, after adjusting for age, gender, tobacco and alcohol, and family history of
tumor, the overall mortality risk of patients with antihypertensive and hypoglycemic therapies
was lower by 42% (HR: 0.58, 95% CI: 0.47-0.73, p<0.001) and 70% (HR: 0.30, 95% CI:
0.24-0.38, p<0.001). Are the HRs in Figure 2 and 3 adjusted hazard ratios? Please explain in
detail how you estimated the HRs in Figures 2 and 3. It appears that the results of univariate
analysis are described as the results of multivariate analysis.
2. In the Survival comparison of medications, "(HR:0.33 compared to HR: 0.71 for Cox
regression and p:0.0152)" and "(HR:0.16 compared to HR: 0.86 for Cox regression, Log-rank
test p:0.0003). What does this mean? What does this mean? Please write the results correctly
so that the reader can understand the meaning correctly. The p-values are also mixed where the
logrank test is written and where it is not.
3. What is the classification of TableS2? Please describe the Characteristic correctly.
4. Please put Tick mark and No. at risk on all KaplanMeier curves.
assistant