Title: Short-term endoscopic alterations of early gastric cancer after successful eradication of
Helicobacter pylori
Version: 2 Date: 04 Nov 2024
Reviewer's report:
Comments to Author
This study was well revised according to Reviewer’s recommendation and suggestion. However,
this version has any problems to be an acceptable level of this journal, as below.
General:
In this study, the authors investigated the endoscopic alterations of early-stage gastric cancer
within 3 months after eradication. Authors showed that the confidence level of demarcation
line and invasion depth and histopathological classification were significantly improved after
eradication. Authors concluded that eradication therapy is necessary even shortly prior to
endoscopic procedure to help precise pre-procedure diagnosis and avoid incomplete resection
Major comments:
1. As authors mention, endoscopists do not recommend eradication therapy before ESD.
However, in this study, the confidence level of demarcation line and invasion depth and
histopathological classification were significantly improved after eradication. What is this
discrepancy with this result and previous?
2. Authors showed significant endoscopic improvement for gastric cancer after eradication.
However, in Japan and Korea, cure rate of ESD for early-stage gastric cancer is high, irrespective
with patients infect currently in H. pylori or not. Therefore, it is unknown whether eradication
therapy before ESD is required or not.
3. In addition, this strategy takes 4-5 months after detection of gastric cancer. If gastric cancer is
diffuse type or borderline lesion for ESD, tumor may advance. Are there any cases that should
not be on this strategy?
4. This is prospective study. Therefore, sample power should be shown.
5. What is second option for gastric cancer patients failed eradication? Second-line eradication
treatment or endoscopic procedure, ESD?
6. Please show approved number in IRB and put it in the revised version.
7. Please show a registration number for clinical trial.
8. In the section of statistical analysis, authors put that continuous variables were expressed as
the mean ± Standard deviation (SD). Please check.
9. Please show information of endoscope used. Was endoscope used same among before
eradication and after eradication?
Title: Short-term endoscopic alterations of early gastric cancer after successful eradication of
Helicobacter pylori
Version: 2 Date: 04 Nov 2024
Reviewer's report:
Comments to Author
This study was well revised according to Reviewer’s recommendation and suggestion. However,
this version has any problems to be an acceptable level of this journal, as below.
General:
In this study, the authors investigated the endoscopic alterations of early-stage gastric cancer
within 3 months after eradication. Authors showed that the confidence level of demarcation
line and invasion depth and histopathological classification were significantly improved after
eradication. Authors concluded that eradication therapy is necessary even shortly prior to
endoscopic procedure to help precise pre-procedure diagnosis and avoid incomplete resection
Major comments:
1. As authors mention, endoscopists do not recommend eradication therapy before ESD.
However, in this study, the confidence level of demarcation line and invasion depth and
histopathological classification were significantly improved after eradication. What is this
discrepancy with this result and previous?
2. Authors showed significant endoscopic improvement for gastric cancer after eradication.
However, in Japan and Korea, cure rate of ESD for early-stage gastric cancer is high, irrespective
with patients infect currently in H. pylori or not. Therefore, it is unknown whether eradication
therapy before ESD is required or not.
3. In addition, this strategy takes 4-5 months after detection of gastric cancer. If gastric cancer is
diffuse type or borderline lesion for ESD, tumor may advance. Are there any cases that should
not be on this strategy?
4. This is prospective study. Therefore, sample power should be shown.
5. What is second option for gastric cancer patients failed eradication? Second-line eradication
treatment or endoscopic procedure, ESD?
6. Please show approved number in IRB and put it in the revised version.
7. Please show a registration number for clinical trial.
8. In the section of statistical analysis, authors put that continuous variables were expressed as
the mean ± Standard deviation (SD). Please check.
9. Please show information of endoscope used. Was endoscope used same among before
eradication and after eradication?
Please review this paper.
user
Title: Short-term endoscopic alterations of early gastric cancer after successful eradication of
Helicobacter pylori
Version: 2 Date: 04 Nov 2024
Reviewer's report:
Comments to Author
This study was well revised according to Reviewer’s recommendation and suggestion. However,
this version has any problems to be an acceptable level of this journal, as below.
General:
In this study, the authors investigated the endoscopic alterations of early-stage gastric cancer
within 3 months after eradication. Authors showed that the confidence level of demarcation
line and invasion depth and histopathological classification were significantly improved after
eradication. Authors concluded that eradication therapy is necessary even shortly prior to
endoscopic procedure to help precise pre-procedure diagnosis and avoid incomplete resection
Major comments:
1. As authors mention, endoscopists do not recommend eradication therapy before ESD.
However, in this study, the confidence level of demarcation line and invasion depth and
histopathological classification were significantly improved after eradication. What is this
discrepancy with this result and previous?
2. Authors showed significant endoscopic improvement for gastric cancer after eradication.
However, in Japan and Korea, cure rate of ESD for early-stage gastric cancer is high, irrespective
with patients infect currently in H. pylori or not. Therefore, it is unknown whether eradication
therapy before ESD is required or not.
3. In addition, this strategy takes 4-5 months after detection of gastric cancer. If gastric cancer is
diffuse type or borderline lesion for ESD, tumor may advance. Are there any cases that should
not be on this strategy?
4. This is prospective study. Therefore, sample power should be shown.
5. What is second option for gastric cancer patients failed eradication? Second-line eradication
treatment or endoscopic procedure, ESD?
6. Please show approved number in IRB and put it in the revised version.
7. Please show a registration number for clinical trial.
8. In the section of statistical analysis, authors put that continuous variables were expressed as
the mean ± Standard deviation (SD). Please check.
9. Please show information of endoscope used. Was endoscope used same among before
eradication and after eradication?
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