Title: Association between dietary antioxidant index and risk of Helicobacter pylori infection
among adults: a case–control study
Version: 2 Date: 12 Jun 2022
Reviewer:  Hong Cheng
Reviewer's report:
Helicobacter pylori infection is closely related to a variety of gastrointestinal diseases and is an
important risk factor for gastric cancer. Exploring the protective factors against Helicobacter
pylori is helpful to the prevention and control of Helicobacter pylori infection. In this case-
control study, the authors investigated the association between dietary antioxidant index and
risk of Helicobacter pylori infection among adults. They found appropriate intake of nutrient
antioxidants may have a role in decreasing the likelihood of Helicobacter pylori infection risk.
There are some problems:
For the healthy control group, when judging that there was no Helicobacter pylori infection, the
patients who had been infected in the past should be excluded.
For those who are judged to have no Helicobacter pylori infection, whether to use any negative
test method to judge that they have no Helicobacter pylori infection, or to use some negative
test methods to judge that they have no Helicobacter pylori infection? For example, if the serum
antibody test and urea breath test are negative, it is judged that the patient has no Helicobacter
pylori infection. Please describe in detail in the article how to judge that the patient has no
Helicobacter pylori infection.
Title: Association between dietary antioxidant index and risk of Helicobacter pylori infection
among adults: a case–control study
Version: 2 Date: 12 Jun 2022
Reviewer:  Hong Cheng
Reviewer's report:
Helicobacter pylori infection is closely related to a variety of gastrointestinal diseases and is an
important risk factor for gastric cancer. Exploring the protective factors against Helicobacter
pylori is helpful to the prevention and control of Helicobacter pylori infection. In this case-
control study, the authors investigated the association between dietary antioxidant index and
risk of Helicobacter pylori infection among adults. They found appropriate intake of nutrient
antioxidants may have a role in decreasing the likelihood of Helicobacter pylori infection risk.
There are some problems:
For the healthy control group, when judging that there was no Helicobacter pylori infection, the
patients who had been infected in the past should be excluded.
For those who are judged to have no Helicobacter pylori infection, whether to use any negative
test method to judge that they have no Helicobacter pylori infection, or to use some negative
test methods to judge that they have no Helicobacter pylori infection? For example, if the serum
antibody test and urea breath test are negative, it is judged that the patient has no Helicobacter
pylori infection. Please describe in detail in the article how to judge that the patient has no
Helicobacter pylori infection.
Please review this paper.
user
Title: Association between dietary antioxidant index and risk of Helicobacter pylori infection
among adults: a case–control study
Version: 2 Date: 12 Jun 2022
Reviewer:  Hong Cheng
Reviewer's report:
Helicobacter pylori infection is closely related to a variety of gastrointestinal diseases and is an
important risk factor for gastric cancer. Exploring the protective factors against Helicobacter
pylori is helpful to the prevention and control of Helicobacter pylori infection. In this case-
control study, the authors investigated the association between dietary antioxidant index and
risk of Helicobacter pylori infection among adults. They found appropriate intake of nutrient
antioxidants may have a role in decreasing the likelihood of Helicobacter pylori infection risk.
There are some problems:
For the healthy control group, when judging that there was no Helicobacter pylori infection, the
patients who had been infected in the past should be excluded.
For those who are judged to have no Helicobacter pylori infection, whether to use any negative
test method to judge that they have no Helicobacter pylori infection, or to use some negative
test methods to judge that they have no Helicobacter pylori infection? For example, if the serum
antibody test and urea breath test are negative, it is judged that the patient has no Helicobacter
pylori infection. Please describe in detail in the article how to judge that the patient has no
Helicobacter pylori infection.
assistant