Reviewer's report
Title:Association of an NFKB1 intron SNP (rs4648068) with gastric cancer
patients in the Han Chinese population
Version: 6Date:24 May 2012
Reviewer: Megan Hitchins
Reviewer's report:
The authors have adequately taken the Reviewer's recommendations into
consideration and included them in manuscript appropriately. I believe this has
improved the overall quality of the paper, so that it now provides a report of an
interesting SNP association with gastric cancer, as well as some ideas in terms
of its functionality, which will impact on future directions. The authors are to be
commended on the quality of their revised paper.
I have only one Minor Essential Revision that I think is required:
The following sentence in the Abstract has been written in such a way it is
factually incorrect:
"Furthermore, stratified by lymph node status and serosa invasion, the effect of
the rs4648068 GG genotype was larger in gastric cancer patients (AORs.....)."
This needs to be corrected, eg suggestion that might fit with word count:
"Furthermore, among the gastric cancer cases, the rs4648068 GG genotype was
associated with high clinical stage (AOR), lymph node involvement (AOR) and
serosa invasion (AOR).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Association of an NFKB1 intron SNP (rs4648068) with gastric cancer
patients in the Han Chinese population
Version: 6Date:24 May 2012
Reviewer: Megan Hitchins
Reviewer's report:
The authors have adequately taken the Reviewer's recommendations into
consideration and included them in manuscript appropriately. I believe this has
improved the overall quality of the paper, so that it now provides a report of an
interesting SNP association with gastric cancer, as well as some ideas in terms
of its functionality, which will impact on future directions. The authors are to be
commended on the quality of their revised paper.
I have only one Minor Essential Revision that I think is required:
The following sentence in the Abstract has been written in such a way it is
factually incorrect:
"Furthermore, stratified by lymph node status and serosa invasion, the effect of
the rs4648068 GG genotype was larger in gastric cancer patients (AORs.....)."
This needs to be corrected, eg suggestion that might fit with word count:
"Furthermore, among the gastric cancer cases, the rs4648068 GG genotype was
associated with high clinical stage (AOR), lymph node involvement (AOR) and
serosa invasion (AOR).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Association of an NFKB1 intron SNP (rs4648068) with gastric cancer
patients in the Han Chinese population
Version: 6Date:24 May 2012
Reviewer: Megan Hitchins
Reviewer's report:
The authors have adequately taken the Reviewer's recommendations into
consideration and included them in manuscript appropriately. I believe this has
improved the overall quality of the paper, so that it now provides a report of an
interesting SNP association with gastric cancer, as well as some ideas in terms
of its functionality, which will impact on future directions. The authors are to be
commended on the quality of their revised paper.
I have only one Minor Essential Revision that I think is required:
The following sentence in the Abstract has been written in such a way it is
factually incorrect:
"Furthermore, stratified by lymph node status and serosa invasion, the effect of
the rs4648068 GG genotype was larger in gastric cancer patients (AORs.....)."
This needs to be corrected, eg suggestion that might fit with word count:
"Furthermore, among the gastric cancer cases, the rs4648068 GG genotype was
associated with high clinical stage (AOR), lymph node involvement (AOR) and
serosa invasion (AOR).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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