Title: Stereotactic body radiation therapy as an effective local treatment for advanced
hepatocellular carcinoma patients with inferior vena cava and right atrial tumor thrombus
Version: 2 Date: 08 Oct 2022
Reviewer's report:
The manuscript is improved and the authors have addresses most of the questions/issues raised.
1. There is a typo in the text of the article where the Child Pugh class distribution is described.
They probably meant that 4 patients had CP B class (rather than A as written)
2. The OAR constraints need to be explicitly provided (I suggest a table or a paragraph dedicated
to detailed description of the constraints
3.  The description of how the authors adjudicated AEs has to be detailed in a paragraph in
the text of the article. It is not sufficient to mention it in the letter of response. This should
include detailed explanation of how the bleeding episodes were ruled out as related to SBRT
and the mean radiation dose to the non involved liver (liver -GTV) in patients who suffered liver
decompensation and died of liver failure.
Title: Stereotactic body radiation therapy as an effective local treatment for advanced
hepatocellular carcinoma patients with inferior vena cava and right atrial tumor thrombus
Version: 2 Date: 08 Oct 2022
Reviewer's report:
The manuscript is improved and the authors have addresses most of the questions/issues raised.
1. There is a typo in the text of the article where the Child Pugh class distribution is described.
They probably meant that 4 patients had CP B class (rather than A as written)
2. The OAR constraints need to be explicitly provided (I suggest a table or a paragraph dedicated
to detailed description of the constraints
3.  The description of how the authors adjudicated AEs has to be detailed in a paragraph in
the text of the article. It is not sufficient to mention it in the letter of response. This should
include detailed explanation of how the bleeding episodes were ruled out as related to SBRT
and the mean radiation dose to the non involved liver (liver -GTV) in patients who suffered liver
decompensation and died of liver failure.
Please review this paper.
user
Title: Stereotactic body radiation therapy as an effective local treatment for advanced
hepatocellular carcinoma patients with inferior vena cava and right atrial tumor thrombus
Version: 2 Date: 08 Oct 2022
Reviewer's report:
The manuscript is improved and the authors have addresses most of the questions/issues raised.
1. There is a typo in the text of the article where the Child Pugh class distribution is described.
They probably meant that 4 patients had CP B class (rather than A as written)
2. The OAR constraints need to be explicitly provided (I suggest a table or a paragraph dedicated
to detailed description of the constraints
3.  The description of how the authors adjudicated AEs has to be detailed in a paragraph in
the text of the article. It is not sufficient to mention it in the letter of response. This should
include detailed explanation of how the bleeding episodes were ruled out as related to SBRT
and the mean radiation dose to the non involved liver (liver -GTV) in patients who suffered liver
decompensation and died of liver failure.
assistant