Reviewer's report 
 Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic Title: 
syndrome? 
 1  31 July 2005 Version: Date: 
 Yao-Yuan S Hsieh Reviewer: 
Reviewer's report: 
1.In general, this manuscript is a rare and interesting report. However, the major defect for this 
manuscript is that authors only demonstrated the family pedigree for LPD. The related molecular 
survey is scanty, which decrease its acceptation scale. Therefore, I strongly suggest that the authors 
should cooperate with molecular biologist and perform some related surveys, including the genetic 
survey and biochemical examination, which will definitely increase its publishing values. 
2.The correlation between LPD and uterine leiomyoma should be addressed. 
3.The mechanism about the association of LPD with Raynaud´s syndrome and Prurigo nodularis 
should be clarified. 
4.The correlation between LPD and estrogen level or estrogen-related gene is obscure, which 
require further survey. 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Reviewer's report 
 Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic Title: 
syndrome? 
 1  31 July 2005 Version: Date: 
 Yao-Yuan S Hsieh Reviewer: 
Reviewer's report: 
1.In general, this manuscript is a rare and interesting report. However, the major defect for this 
manuscript is that authors only demonstrated the family pedigree for LPD. The related molecular 
survey is scanty, which decrease its acceptation scale. Therefore, I strongly suggest that the authors 
should cooperate with molecular biologist and perform some related surveys, including the genetic 
survey and biochemical examination, which will definitely increase its publishing values. 
2.The correlation between LPD and uterine leiomyoma should be addressed. 
3.The mechanism about the association of LPD with Raynaud´s syndrome and Prurigo nodularis 
should be clarified. 
4.The correlation between LPD and estrogen level or estrogen-related gene is obscure, which 
require further survey. 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Please review this paper.
user
Reviewer's report 
 Familial clustering of Leiomyomatosis peritonealis disseminata: an unknown genetic Title: 
syndrome? 
 1  31 July 2005 Version: Date: 
 Yao-Yuan S Hsieh Reviewer: 
Reviewer's report: 
1.In general, this manuscript is a rare and interesting report. However, the major defect for this 
manuscript is that authors only demonstrated the family pedigree for LPD. The related molecular 
survey is scanty, which decrease its acceptation scale. Therefore, I strongly suggest that the authors 
should cooperate with molecular biologist and perform some related surveys, including the genetic 
survey and biochemical examination, which will definitely increase its publishing values. 
2.The correlation between LPD and uterine leiomyoma should be addressed. 
3.The mechanism about the association of LPD with Raynaud´s syndrome and Prurigo nodularis 
should be clarified. 
4.The correlation between LPD and estrogen level or estrogen-related gene is obscure, which 
require further survey. 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
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