Reviewer ’s report  
 
Title: Re-bleeding and its predictors after capsule end oscopy in patients with obscure 
gastrointestinal bleeding in long -term follow -up 
 
Version: 0 Date: 12 Jul 2019  
 
Reviewer: Renato Cannizzaro  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
 
Please over write this text when adding your comments to the authors.  
 
 
This is an interesting report on important clinical problem:  
 
 
If CE is useful in reducing rebleeding.  
 
 
This sentence must be shortned:  
 
Among 58 patients with positive findings on initial CE, 21 patients (36%) had a rebleeding 
event. The re -bleeding event occurred in 47% (8/17) of patients who had angiodysplasia, 
followed by 40% (4/10) of vascular lesions, 30% (6/20) of small bowel ulcer,  and 30% (3/10) of 
small bowel tumor. To identify the etiologies of recurrent bleeding, EGD, colonoscopy, device -
assisted endoscopy, computer tomography with angiography or repeat CE were performed after 
the re -bleeding events. In the group of positive find ings on the initial CE, re -bleeding occurred in 
21 patients  
 
 
How many patients were treated wuth Rebamipide?  
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your  comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please  explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisati on that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscrip t, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents  relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no co mpeting interests' 
below. If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Acc ess Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understa nd that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
 
 
Reviewer ’s report  
 
Title: Re-bleeding and its predictors after capsule end oscopy in patients with obscure 
gastrointestinal bleeding in long -term follow -up 
 
Version: 0 Date: 12 Jul 2019  
 
Reviewer: Renato Cannizzaro  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
 
Please over write this text when adding your comments to the authors.  
 
 
This is an interesting report on important clinical problem:  
 
 
If CE is useful in reducing rebleeding.  
 
 
This sentence must be shortned:  
 
Among 58 patients with positive findings on initial CE, 21 patients (36%) had a rebleeding 
event. The re -bleeding event occurred in 47% (8/17) of patients who had angiodysplasia, 
followed by 40% (4/10) of vascular lesions, 30% (6/20) of small bowel ulcer,  and 30% (3/10) of 
small bowel tumor. To identify the etiologies of recurrent bleeding, EGD, colonoscopy, device -
assisted endoscopy, computer tomography with angiography or repeat CE were performed after 
the re -bleeding events. In the group of positive find ings on the initial CE, re -bleeding occurred in 
21 patients  
 
 
How many patients were treated wuth Rebamipide?  
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your  comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please  explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisati on that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscrip t, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents  relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no co mpeting interests' 
below. If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Acc ess Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understa nd that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
 
 
Please review this paper.
user
Reviewer ’s report  
 
Title: Re-bleeding and its predictors after capsule end oscopy in patients with obscure 
gastrointestinal bleeding in long -term follow -up 
 
Version: 0 Date: 12 Jul 2019  
 
Reviewer: Renato Cannizzaro  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
 
Please over write this text when adding your comments to the authors.  
 
 
This is an interesting report on important clinical problem:  
 
 
If CE is useful in reducing rebleeding.  
 
 
This sentence must be shortned:  
 
Among 58 patients with positive findings on initial CE, 21 patients (36%) had a rebleeding 
event. The re -bleeding event occurred in 47% (8/17) of patients who had angiodysplasia, 
followed by 40% (4/10) of vascular lesions, 30% (6/20) of small bowel ulcer,  and 30% (3/10) of 
small bowel tumor. To identify the etiologies of recurrent bleeding, EGD, colonoscopy, device -
assisted endoscopy, computer tomography with angiography or repeat CE were performed after 
the re -bleeding events. In the group of positive find ings on the initial CE, re -bleeding occurred in 
21 patients  
 
 
How many patients were treated wuth Rebamipide?  
 
 
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your  comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please  explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisati on that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscrip t, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents  relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no co mpeting interests' 
below. If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Acc ess Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understa nd that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
 
 
assistant