Reviewer ’s report  
 
Title: The impact of diagnosis on health -related quality of life in people with coeliac disease: a 
UK popu lation -based longitudinal perspective  
 
Version: 0 Date: 30 Sep 2018  
 
Reviewer: Fabiana Zingone  
 
Reviewer's report:  
 
In the paper entitled "Quality of life in people with coeliac disease before and after diagnosis: a 
UK population -based longitudinal perspective", the authors reported and compared two surveys 
on the impact of celiac diagnosis on patients'life conducted in  2006 and 2015. It is an interesting 
topic and a well written paper, however, the reviewer believes that the work needs minor 
essential revisions which are reported below:  
- The title and most of the paper are only focused on quality of life, however the s urvey 
analysed several aspects of the patients 'life. So, the reviewer believes that the title and part 
of the text should be more related to all study's aims: symptoms, costs, limitations, dietary 
compliance etc. Possible title could be "the impact of coe liac diagnosis on patients'life" for 
example.  
 
- In the methods, the authors should add two separated paragraphs reporting the information 
of Table 1 with more details on both surveys and both study populations. At this time, data 
on 2006 survey are not cl ear.  Are the study population the same?  
 
- The multiple comparisons between survey 2006 and survey 2015 made reading difficult. 
Please try to simplify all the information in the text.  
 
- Are data regarding 2006 survey published anywhere?     
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
  
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are yo u able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able  to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have  you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content o f the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any  non-financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included i n my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: The impact of diagnosis on health -related quality of life in people with coeliac disease: a 
UK popu lation -based longitudinal perspective  
 
Version: 0 Date: 30 Sep 2018  
 
Reviewer: Fabiana Zingone  
 
Reviewer's report:  
 
In the paper entitled "Quality of life in people with coeliac disease before and after diagnosis: a 
UK population -based longitudinal perspective", the authors reported and compared two surveys 
on the impact of celiac diagnosis on patients'life conducted in  2006 and 2015. It is an interesting 
topic and a well written paper, however, the reviewer believes that the work needs minor 
essential revisions which are reported below:  
- The title and most of the paper are only focused on quality of life, however the s urvey 
analysed several aspects of the patients 'life. So, the reviewer believes that the title and part 
of the text should be more related to all study's aims: symptoms, costs, limitations, dietary 
compliance etc. Possible title could be "the impact of coe liac diagnosis on patients'life" for 
example.  
 
- In the methods, the authors should add two separated paragraphs reporting the information 
of Table 1 with more details on both surveys and both study populations. At this time, data 
on 2006 survey are not cl ear.  Are the study population the same?  
 
- The multiple comparisons between survey 2006 and survey 2015 made reading difficult. 
Please try to simplify all the information in the text.  
 
- Are data regarding 2006 survey published anywhere?     
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
  
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are yo u able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able  to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have  you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content o f the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any  non-financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included i n my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: The impact of diagnosis on health -related quality of life in people with coeliac disease: a 
UK popu lation -based longitudinal perspective  
 
Version: 0 Date: 30 Sep 2018  
 
Reviewer: Fabiana Zingone  
 
Reviewer's report:  
 
In the paper entitled "Quality of life in people with coeliac disease before and after diagnosis: a 
UK population -based longitudinal perspective", the authors reported and compared two surveys 
on the impact of celiac diagnosis on patients'life conducted in  2006 and 2015. It is an interesting 
topic and a well written paper, however, the reviewer believes that the work needs minor 
essential revisions which are reported below:  
- The title and most of the paper are only focused on quality of life, however the s urvey 
analysed several aspects of the patients 'life. So, the reviewer believes that the title and part 
of the text should be more related to all study's aims: symptoms, costs, limitations, dietary 
compliance etc. Possible title could be "the impact of coe liac diagnosis on patients'life" for 
example.  
 
- In the methods, the authors should add two separated paragraphs reporting the information 
of Table 1 with more details on both surveys and both study populations. At this time, data 
on 2006 survey are not cl ear.  Are the study population the same?  
 
- The multiple comparisons between survey 2006 and survey 2015 made reading difficult. 
Please try to simplify all the information in the text.  
 
- Are data regarding 2006 survey published anywhere?     
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
  
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are yo u able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able  to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have  you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content o f the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any  non-financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included i n my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant