Title: Age is the only predictor for upper gastrointestinal malignancy in Chinese patients with
uncomplicated dyspepsia: a prospective investigation of endoscopic findings
Version: 0 Date: 29 Aug 2021
Reviewer's report:
Dear Authors
Manuscript: Age the only predictor for upper gastrointestinal malignancy in Chinese patients
with uncomplicated dyspepsia: a prospective investigation of endoscopic findings.
This is a nice study done in China, Renji Hospital, Shanghai which is a single center prospective
observational study with a huge number of upper gastrointestinal symptoms patients underwent
esophagogastroduodenoscopy (EGD) with the aim to find the risk factors of major pathological
endoscopic findings in this group of patients.  The aim of this study is quite useful for the reader
in terms of selection appropriate patient to undergo EGD which is common problem in clinical
practice.
Major issues
In abstract at the conclusion, the “indication” should be used for the investigation rather than
for the diagnosis.  So, this should be revised.
In study design for the factor associated with the major lesions: The authors found esophageal
cancer 0.3% (15 cases) which one factor commonly associated with esophageal cancer is head
and neck cancer (5-30%), did the authors have this data which should be analyzed and included
in this study.
In Discussion and conclusion, Main discussion is focusing in upper GI malignancy but not the
peptic ulcer disease which was found more commonly than malignancy.  So, I would suggest to
add the predictors for peptic ulcer disease in discussion and conclusion as well.
Minor issues
The topic of this manuscript as “Age the only predictor”, I suggest to add is after age.  Thus,
it will be: Age is the only…………
Page 4 Line 3, because of dyspepsia should be “because of upper gastrointestinal symptoms”
Page 4 Line 11, with dyspepsia should be “with upper gastrointestinal symptoms”
I recommend language editing
Title: Age is the only predictor for upper gastrointestinal malignancy in Chinese patients with
uncomplicated dyspepsia: a prospective investigation of endoscopic findings
Version: 0 Date: 29 Aug 2021
Reviewer's report:
Dear Authors
Manuscript: Age the only predictor for upper gastrointestinal malignancy in Chinese patients
with uncomplicated dyspepsia: a prospective investigation of endoscopic findings.
This is a nice study done in China, Renji Hospital, Shanghai which is a single center prospective
observational study with a huge number of upper gastrointestinal symptoms patients underwent
esophagogastroduodenoscopy (EGD) with the aim to find the risk factors of major pathological
endoscopic findings in this group of patients.  The aim of this study is quite useful for the reader
in terms of selection appropriate patient to undergo EGD which is common problem in clinical
practice.
Major issues
In abstract at the conclusion, the “indication” should be used for the investigation rather than
for the diagnosis.  So, this should be revised.
In study design for the factor associated with the major lesions: The authors found esophageal
cancer 0.3% (15 cases) which one factor commonly associated with esophageal cancer is head
and neck cancer (5-30%), did the authors have this data which should be analyzed and included
in this study.
In Discussion and conclusion, Main discussion is focusing in upper GI malignancy but not the
peptic ulcer disease which was found more commonly than malignancy.  So, I would suggest to
add the predictors for peptic ulcer disease in discussion and conclusion as well.
Minor issues
The topic of this manuscript as “Age the only predictor”, I suggest to add is after age.  Thus,
it will be: Age is the only…………
Page 4 Line 3, because of dyspepsia should be “because of upper gastrointestinal symptoms”
Page 4 Line 11, with dyspepsia should be “with upper gastrointestinal symptoms”
I recommend language editing
Please review this paper.
user
Title: Age is the only predictor for upper gastrointestinal malignancy in Chinese patients with
uncomplicated dyspepsia: a prospective investigation of endoscopic findings
Version: 0 Date: 29 Aug 2021
Reviewer's report:
Dear Authors
Manuscript: Age the only predictor for upper gastrointestinal malignancy in Chinese patients
with uncomplicated dyspepsia: a prospective investigation of endoscopic findings.
This is a nice study done in China, Renji Hospital, Shanghai which is a single center prospective
observational study with a huge number of upper gastrointestinal symptoms patients underwent
esophagogastroduodenoscopy (EGD) with the aim to find the risk factors of major pathological
endoscopic findings in this group of patients.  The aim of this study is quite useful for the reader
in terms of selection appropriate patient to undergo EGD which is common problem in clinical
practice.
Major issues
In abstract at the conclusion, the “indication” should be used for the investigation rather than
for the diagnosis.  So, this should be revised.
In study design for the factor associated with the major lesions: The authors found esophageal
cancer 0.3% (15 cases) which one factor commonly associated with esophageal cancer is head
and neck cancer (5-30%), did the authors have this data which should be analyzed and included
in this study.
In Discussion and conclusion, Main discussion is focusing in upper GI malignancy but not the
peptic ulcer disease which was found more commonly than malignancy.  So, I would suggest to
add the predictors for peptic ulcer disease in discussion and conclusion as well.
Minor issues
The topic of this manuscript as “Age the only predictor”, I suggest to add is after age.  Thus,
it will be: Age is the only…………
Page 4 Line 3, because of dyspepsia should be “because of upper gastrointestinal symptoms”
Page 4 Line 11, with dyspepsia should be “with upper gastrointestinal symptoms”
I recommend language editing
assistant