Reviewer's report 
 Tracing Ancestry With Methylation Patterns: Most Crypts Appear Distantly Related in Normal Adult Title: 
Human Colon 
 2  31 March 2004 Version: Date: 
 Jean-Pierre Issa Reviewer: 
Reviewer's report: 
I think the manuscript is a useful contribution that is interesting and worth 
publication. The reviewer makes an excellent point that is one of my concerns as well, ie the power of the technique is difficult to discern 
without clear cut controls, though they do show a higher degree of 
intracrypt than intercrypt homogeneity (which is reassuring). Given your 
open review system, I would recommend publication, and readers will have access to the reviews and responses for further thinking/information. 
Reviewer's report 
 Tracing Ancestry With Methylation Patterns: Most Crypts Appear Distantly Related in Normal Adult Title: 
Human Colon 
 2  31 March 2004 Version: Date: 
 Jean-Pierre Issa Reviewer: 
Reviewer's report: 
I think the manuscript is a useful contribution that is interesting and worth 
publication. The reviewer makes an excellent point that is one of my concerns as well, ie the power of the technique is difficult to discern 
without clear cut controls, though they do show a higher degree of 
intracrypt than intercrypt homogeneity (which is reassuring). Given your 
open review system, I would recommend publication, and readers will have access to the reviews and responses for further thinking/information. 
Please review this paper.
user
Reviewer's report 
 Tracing Ancestry With Methylation Patterns: Most Crypts Appear Distantly Related in Normal Adult Title: 
Human Colon 
 2  31 March 2004 Version: Date: 
 Jean-Pierre Issa Reviewer: 
Reviewer's report: 
I think the manuscript is a useful contribution that is interesting and worth 
publication. The reviewer makes an excellent point that is one of my concerns as well, ie the power of the technique is difficult to discern 
without clear cut controls, though they do show a higher degree of 
intracrypt than intercrypt homogeneity (which is reassuring). Given your 
open review system, I would recommend publication, and readers will have access to the reviews and responses for further thinking/information. 
assistant