Title: Total polyp number may be more important than size and histology of polyps for
prediction of metachronous high-risk colorectal neoplasms
Version: 1 Date: 06 Nov 2021
Reviewer:  Yuusaku Sugihara
Reviewer's report:
The authors evaluated whether the risk of metachronous high-risk colorectal neoplasm (HR-
CRN) differs according to the indication for surveillance colonoscopy. And the result the risk
of metachronous HR-CRN did not differ according to the main indications for surveillance
colonoscopy. The presence of 5 or more polyps at index colonoscopy was the only risk factor
for metachronous HR-CRN.
 This report represents an effort to accomplish this, as these data will most likely prove to be
a unique resource well into the future. I think this paper should be published. But I have some
suggestions to add. The author states in the conclusion that follow CS should be implemented
within 3 years, but this paper does not emphasize the grounds for within 3 years.
Title: Total polyp number may be more important than size and histology of polyps for
prediction of metachronous high-risk colorectal neoplasms
Version: 1 Date: 06 Nov 2021
Reviewer:  Yuusaku Sugihara
Reviewer's report:
The authors evaluated whether the risk of metachronous high-risk colorectal neoplasm (HR-
CRN) differs according to the indication for surveillance colonoscopy. And the result the risk
of metachronous HR-CRN did not differ according to the main indications for surveillance
colonoscopy. The presence of 5 or more polyps at index colonoscopy was the only risk factor
for metachronous HR-CRN.
 This report represents an effort to accomplish this, as these data will most likely prove to be
a unique resource well into the future. I think this paper should be published. But I have some
suggestions to add. The author states in the conclusion that follow CS should be implemented
within 3 years, but this paper does not emphasize the grounds for within 3 years.
Please review this paper.
user
Title: Total polyp number may be more important than size and histology of polyps for
prediction of metachronous high-risk colorectal neoplasms
Version: 1 Date: 06 Nov 2021
Reviewer:  Yuusaku Sugihara
Reviewer's report:
The authors evaluated whether the risk of metachronous high-risk colorectal neoplasm (HR-
CRN) differs according to the indication for surveillance colonoscopy. And the result the risk
of metachronous HR-CRN did not differ according to the main indications for surveillance
colonoscopy. The presence of 5 or more polyps at index colonoscopy was the only risk factor
for metachronous HR-CRN.
 This report represents an effort to accomplish this, as these data will most likely prove to be
a unique resource well into the future. I think this paper should be published. But I have some
suggestions to add. The author states in the conclusion that follow CS should be implemented
within 3 years, but this paper does not emphasize the grounds for within 3 years.
assistant