Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 3 Date: 14 Apr 2021
Reviewer's report:
1.Although the diagnostic criteria and staging of ICA-AKI are very similar to the traditional
AKIN and KDIGO staging, I would favor the use of specific diagnoses and staging for specific
types of AKI, such as HRS.
In this paper, the definition of conventional AKI is simple. Can the authors use AKIN or KDIGO
definition to define conventional AKI and clarify the advantages of ICA?
For example, compare which diagnostic criteria has a higher incidence of AKI and which stage
is an influential factor in mortality.
If the results showed that both are similar, then why did the authors recommend the ICA
diagnostic criteria for patients with variceal bleeding.
2.“These findings suggested that the cut-off level of serum creatinine at 1.5 mg/dL has a
significant effect on the 6-week study.” This statement makes no sense because the authors have
previously shown that the mortality rate for all stages of ICA-AKI is higher than that for non-
AKI.
3."Patients with AKI stage 1b had higher 6-week mortality rate (46.7%; P = 0.080) than those
with initial AKI stage 2 (25.6%); However, this difference was not significant. " Confusing,
since it is not statistically significant, why is stage 1b higher than stage 2?
4.Although the article has been revised by an English editor, there are still some mistakes in
grammar or tense. “Effect of AKI on survival These findings suggest that the cut-off level of
serum creatinine...” It should be in the past tense.
Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 3 Date: 14 Apr 2021
Reviewer's report:
1.Although the diagnostic criteria and staging of ICA-AKI are very similar to the traditional
AKIN and KDIGO staging, I would favor the use of specific diagnoses and staging for specific
types of AKI, such as HRS.
In this paper, the definition of conventional AKI is simple. Can the authors use AKIN or KDIGO
definition to define conventional AKI and clarify the advantages of ICA?
For example, compare which diagnostic criteria has a higher incidence of AKI and which stage
is an influential factor in mortality.
If the results showed that both are similar, then why did the authors recommend the ICA
diagnostic criteria for patients with variceal bleeding.
2.“These findings suggested that the cut-off level of serum creatinine at 1.5 mg/dL has a
significant effect on the 6-week study.” This statement makes no sense because the authors have
previously shown that the mortality rate for all stages of ICA-AKI is higher than that for non-
AKI.
3."Patients with AKI stage 1b had higher 6-week mortality rate (46.7%; P = 0.080) than those
with initial AKI stage 2 (25.6%); However, this difference was not significant. " Confusing,
since it is not statistically significant, why is stage 1b higher than stage 2?
4.Although the article has been revised by an English editor, there are still some mistakes in
grammar or tense. “Effect of AKI on survival These findings suggest that the cut-off level of
serum creatinine...” It should be in the past tense.
Please review this paper.
user
Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 3 Date: 14 Apr 2021
Reviewer's report:
1.Although the diagnostic criteria and staging of ICA-AKI are very similar to the traditional
AKIN and KDIGO staging, I would favor the use of specific diagnoses and staging for specific
types of AKI, such as HRS.
In this paper, the definition of conventional AKI is simple. Can the authors use AKIN or KDIGO
definition to define conventional AKI and clarify the advantages of ICA?
For example, compare which diagnostic criteria has a higher incidence of AKI and which stage
is an influential factor in mortality.
If the results showed that both are similar, then why did the authors recommend the ICA
diagnostic criteria for patients with variceal bleeding.
2.“These findings suggested that the cut-off level of serum creatinine at 1.5 mg/dL has a
significant effect on the 6-week study.” This statement makes no sense because the authors have
previously shown that the mortality rate for all stages of ICA-AKI is higher than that for non-
AKI.
3."Patients with AKI stage 1b had higher 6-week mortality rate (46.7%; P = 0.080) than those
with initial AKI stage 2 (25.6%); However, this difference was not significant. " Confusing,
since it is not statistically significant, why is stage 1b higher than stage 2?
4.Although the article has been revised by an English editor, there are still some mistakes in
grammar or tense. “Effect of AKI on survival These findings suggest that the cut-off level of
serum creatinine...” It should be in the past tense.
assistant