Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 4 Date: 05 Jul 2024
Reviewer:  angela spinola
Reviewer's report:
Dear authors, I appreciate your work on this study. Your study seems to be well done, and it
tackles a crucial health problem, Celiac disease, among children with type 1 diabetes in Nigeria.
It offers a clear contribution, such as a clear recommendation for screening and early diagnosis
of CD in children with T1DM, especially highlighting the need for more awareness among
healthcare providers. However, some areas could be improved to make the study more robust.
1-As you know, the confirmatory biopsies would increase the diagnostic precision, besides the
importance of the antibodies  2-I think a longitudinal study design would reveal the impact
of CD on the quality of life of T1DM patients. 3-Having a control group of children without
T1DM could help compare the prevalence of CD in the general population with those with
T1DM. 4-Detailed Symptom Analysis: A more detailed analysis of gastrointestinal and other
symptoms could help find specific clinical markers indicative of CD in T1DM patients. 5—
Diabetes control in the group of significantly affected patients is essential to provide a clinical
clue for the diagnosis. 6- I missed family history about other autoimmune diseases and CD. 7-
In the discussion, a better analysis of possible genetic differences between Nigeria populations
in the North is needed  8- Writing needs corrections
Your study needed these details to show a difference. Otherwise, you only reported the frequency
of CD in Nigeria, which is not new to research. Previous studies did the same thing, so you did
not find any new data. If you could compare the genetics of the populations or the environment,
you could offer new insights and contribute to this field.
Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 4 Date: 05 Jul 2024
Reviewer:  angela spinola
Reviewer's report:
Dear authors, I appreciate your work on this study. Your study seems to be well done, and it
tackles a crucial health problem, Celiac disease, among children with type 1 diabetes in Nigeria.
It offers a clear contribution, such as a clear recommendation for screening and early diagnosis
of CD in children with T1DM, especially highlighting the need for more awareness among
healthcare providers. However, some areas could be improved to make the study more robust.
1-As you know, the confirmatory biopsies would increase the diagnostic precision, besides the
importance of the antibodies  2-I think a longitudinal study design would reveal the impact
of CD on the quality of life of T1DM patients. 3-Having a control group of children without
T1DM could help compare the prevalence of CD in the general population with those with
T1DM. 4-Detailed Symptom Analysis: A more detailed analysis of gastrointestinal and other
symptoms could help find specific clinical markers indicative of CD in T1DM patients. 5—
Diabetes control in the group of significantly affected patients is essential to provide a clinical
clue for the diagnosis. 6- I missed family history about other autoimmune diseases and CD. 7-
In the discussion, a better analysis of possible genetic differences between Nigeria populations
in the North is needed  8- Writing needs corrections
Your study needed these details to show a difference. Otherwise, you only reported the frequency
of CD in Nigeria, which is not new to research. Previous studies did the same thing, so you did
not find any new data. If you could compare the genetics of the populations or the environment,
you could offer new insights and contribute to this field.
Please review this paper.
user
Title: Celiac disease autoimmunity among Nigerian children and adolescents with type 1
diabetes mellitus
Version: 4 Date: 05 Jul 2024
Reviewer:  angela spinola
Reviewer's report:
Dear authors, I appreciate your work on this study. Your study seems to be well done, and it
tackles a crucial health problem, Celiac disease, among children with type 1 diabetes in Nigeria.
It offers a clear contribution, such as a clear recommendation for screening and early diagnosis
of CD in children with T1DM, especially highlighting the need for more awareness among
healthcare providers. However, some areas could be improved to make the study more robust.
1-As you know, the confirmatory biopsies would increase the diagnostic precision, besides the
importance of the antibodies  2-I think a longitudinal study design would reveal the impact
of CD on the quality of life of T1DM patients. 3-Having a control group of children without
T1DM could help compare the prevalence of CD in the general population with those with
T1DM. 4-Detailed Symptom Analysis: A more detailed analysis of gastrointestinal and other
symptoms could help find specific clinical markers indicative of CD in T1DM patients. 5—
Diabetes control in the group of significantly affected patients is essential to provide a clinical
clue for the diagnosis. 6- I missed family history about other autoimmune diseases and CD. 7-
In the discussion, a better analysis of possible genetic differences between Nigeria populations
in the North is needed  8- Writing needs corrections
Your study needed these details to show a difference. Otherwise, you only reported the frequency
of CD in Nigeria, which is not new to research. Previous studies did the same thing, so you did
not find any new data. If you could compare the genetics of the populations or the environment,
you could offer new insights and contribute to this field.
assistant