Reviewer's report
Title:Gastroesophageal reflux leads to esophageal cancer in a surgical model
with mice
Version: 1Date:7 August 2008
Reviewer: Takanori Hattori
Reviewer's report:
The authors deal with a mouse model of Barrett’s esophagus (BE) and
esophageal adenocarcinoma (EAC). They tried to establish this mouse model by
surgical procedure with esophago-gastroduodenal anastomosis (EGDA) on
wild-type, p53A135V transgenic, and INK4a/Arf+/- mice of A/J strain. However,
EGDA induced only esophageal squamous cell carcinoma (ESCC), but not BE
and EAC, in these mice.
The results are unexpectedly negative data. However, the study is well designed,
and the manuscript is well written. Moreover, the manuscript has some interests
about association between duodenal contents reflux and development of ESCC.
So, the manuscript should be accepted without any revisions.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Gastroesophageal reflux leads to esophageal cancer in a surgical model
with mice
Version: 1Date:7 August 2008
Reviewer: Takanori Hattori
Reviewer's report:
The authors deal with a mouse model of Barrett’s esophagus (BE) and
esophageal adenocarcinoma (EAC). They tried to establish this mouse model by
surgical procedure with esophago-gastroduodenal anastomosis (EGDA) on
wild-type, p53A135V transgenic, and INK4a/Arf+/- mice of A/J strain. However,
EGDA induced only esophageal squamous cell carcinoma (ESCC), but not BE
and EAC, in these mice.
The results are unexpectedly negative data. However, the study is well designed,
and the manuscript is well written. Moreover, the manuscript has some interests
about association between duodenal contents reflux and development of ESCC.
So, the manuscript should be accepted without any revisions.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Gastroesophageal reflux leads to esophageal cancer in a surgical model
with mice
Version: 1Date:7 August 2008
Reviewer: Takanori Hattori
Reviewer's report:
The authors deal with a mouse model of Barrett’s esophagus (BE) and
esophageal adenocarcinoma (EAC). They tried to establish this mouse model by
surgical procedure with esophago-gastroduodenal anastomosis (EGDA) on
wild-type, p53A135V transgenic, and INK4a/Arf+/- mice of A/J strain. However,
EGDA induced only esophageal squamous cell carcinoma (ESCC), but not BE
and EAC, in these mice.
The results are unexpectedly negative data. However, the study is well designed,
and the manuscript is well written. Moreover, the manuscript has some interests
about association between duodenal contents reflux and development of ESCC.
So, the manuscript should be accepted without any revisions.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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