Title: Investigating the Effect of Quadruple Therapy with Saccharomyces Boulardii or
Lactobacillus Reuteri Strain (DSMZ 17648) Supplements on Eradication of Helicobacter Pylori
and Treatments# Adverse effects: A Double-Blind Placebo-Controlled Randomized Clinical
Trial
Version: 5 Date: 24 Jan 2022
Reviewer's report:
After major revised of manuscripts, I still have some concerned
1. Positive of Helicobacter pylori (H.pylori)
Authors used pathology & for confirmation of H. pylori eradication & follow up, H. pylori stool
Ag.
(1) Suggested to add ‘pathology with Giemsa stain “in sentence.
I had concerned which part was taken biopsy (Antrum or body, or both).
H.pylori detection rate was poor in antrum of atrophy gastritis.
(2)Which stool kit of H. pylori stool Ag were used? Different kit has the different sensitivity,
specificity, diagnostic rate.
2.What kinds of proton pump inhibitors choice in this study#
esomeprazole. (Nexium®) # lansoprazole (Takepron®. OD) # pantoprazole (Pantoloc®) #
rabeprazole(pariet).
Author did not answer this question.
3. Methods, page 5, lines 102 - 109
May consider revise this part briefly because most parts are duplicated in the other parts of the
manuscript(result section).
4. Methods, page 6, line 131 and lines 122 - 124.
"Patients with the history of gastric surgery" and "patients with the history ... stomach or ..."
are duplicated.
Authors did not revise these parts.
5. Limitations, page 12, line 283
"The main limitation of this study was poor cooperation" Some patients refused to come for H.
pylori stool Ag testing. But no study dropped out?
Title: Investigating the Effect of Quadruple Therapy with Saccharomyces Boulardii or
Lactobacillus Reuteri Strain (DSMZ 17648) Supplements on Eradication of Helicobacter Pylori
and Treatments# Adverse effects: A Double-Blind Placebo-Controlled Randomized Clinical
Trial
Version: 5 Date: 24 Jan 2022
Reviewer's report:
After major revised of manuscripts, I still have some concerned
1. Positive of Helicobacter pylori (H.pylori)
Authors used pathology & for confirmation of H. pylori eradication & follow up, H. pylori stool
Ag.
(1) Suggested to add ‘pathology with Giemsa stain “in sentence.
I had concerned which part was taken biopsy (Antrum or body, or both).
H.pylori detection rate was poor in antrum of atrophy gastritis.
(2)Which stool kit of H. pylori stool Ag were used? Different kit has the different sensitivity,
specificity, diagnostic rate.
2.What kinds of proton pump inhibitors choice in this study#
esomeprazole. (Nexium®) # lansoprazole (Takepron®. OD) # pantoprazole (Pantoloc®) #
rabeprazole(pariet).
Author did not answer this question.
3. Methods, page 5, lines 102 - 109
May consider revise this part briefly because most parts are duplicated in the other parts of the
manuscript(result section).
4. Methods, page 6, line 131 and lines 122 - 124.
"Patients with the history of gastric surgery" and "patients with the history ... stomach or ..."
are duplicated.
Authors did not revise these parts.
5. Limitations, page 12, line 283
"The main limitation of this study was poor cooperation" Some patients refused to come for H.
pylori stool Ag testing. But no study dropped out?
Please review this paper.
user
Title: Investigating the Effect of Quadruple Therapy with Saccharomyces Boulardii or
Lactobacillus Reuteri Strain (DSMZ 17648) Supplements on Eradication of Helicobacter Pylori
and Treatments# Adverse effects: A Double-Blind Placebo-Controlled Randomized Clinical
Trial
Version: 5 Date: 24 Jan 2022
Reviewer's report:
After major revised of manuscripts, I still have some concerned
1. Positive of Helicobacter pylori (H.pylori)
Authors used pathology & for confirmation of H. pylori eradication & follow up, H. pylori stool
Ag.
(1) Suggested to add ‘pathology with Giemsa stain “in sentence.
I had concerned which part was taken biopsy (Antrum or body, or both).
H.pylori detection rate was poor in antrum of atrophy gastritis.
(2)Which stool kit of H. pylori stool Ag were used? Different kit has the different sensitivity,
specificity, diagnostic rate.
2.What kinds of proton pump inhibitors choice in this study#
esomeprazole. (Nexium®) # lansoprazole (Takepron®. OD) # pantoprazole (Pantoloc®) #
rabeprazole(pariet).
Author did not answer this question.
3. Methods, page 5, lines 102 - 109
May consider revise this part briefly because most parts are duplicated in the other parts of the
manuscript(result section).
4. Methods, page 6, line 131 and lines 122 - 124.
"Patients with the history of gastric surgery" and "patients with the history ... stomach or ..."
are duplicated.
Authors did not revise these parts.
5. Limitations, page 12, line 283
"The main limitation of this study was poor cooperation" Some patients refused to come for H.
pylori stool Ag testing. But no study dropped out?
assistant