Title: Biochemical and histopathological evidence for beneficial effects of empagliflozin
pretreatment on acetic acid-induced colitis in rats
Version: 3 Date: 21 Mar 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors had responded to some of the comments, but not all
comments were satisfactorily addressed.
The manuscript needs revision.
ADDITIONAL REQUESTS/SUGGESTIONS:
The manuscript does not read well. I suggest that the authors have the manuscript sent for
professional services/editing.
There are still typo-graphical errors and inconsistencies in the format and symbols used.
Not all the comments given previously were addressed. The Discussion specifically. I strongly
suggest that it is put into different paragraph to improve the readability of the section.
It remains unclear as to how Empa, which acts on a receptor in the kidney, ameliorates oxidative
stress in the colon."
Title: Biochemical and histopathological evidence for beneficial effects of empagliflozin
pretreatment on acetic acid-induced colitis in rats
Version: 3 Date: 21 Mar 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors had responded to some of the comments, but not all
comments were satisfactorily addressed.
The manuscript needs revision.
ADDITIONAL REQUESTS/SUGGESTIONS:
The manuscript does not read well. I suggest that the authors have the manuscript sent for
professional services/editing.
There are still typo-graphical errors and inconsistencies in the format and symbols used.
Not all the comments given previously were addressed. The Discussion specifically. I strongly
suggest that it is put into different paragraph to improve the readability of the section.
It remains unclear as to how Empa, which acts on a receptor in the kidney, ameliorates oxidative
stress in the colon."
Please review this paper.
user
Title: Biochemical and histopathological evidence for beneficial effects of empagliflozin
pretreatment on acetic acid-induced colitis in rats
Version: 3 Date: 21 Mar 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors had responded to some of the comments, but not all
comments were satisfactorily addressed.
The manuscript needs revision.
ADDITIONAL REQUESTS/SUGGESTIONS:
The manuscript does not read well. I suggest that the authors have the manuscript sent for
professional services/editing.
There are still typo-graphical errors and inconsistencies in the format and symbols used.
Not all the comments given previously were addressed. The Discussion specifically. I strongly
suggest that it is put into different paragraph to improve the readability of the section.
It remains unclear as to how Empa, which acts on a receptor in the kidney, ameliorates oxidative
stress in the colon."
assistant