Title: The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis
and related mortality: Results from an umbrella meta-analysis on meta-analyses of randomized
controlled trials
Version: 0 Date: 09 Dec 2024
Reviewer:  Gaohong Wu
Reviewer's report:
The effectiveness of treatment with probiotics in preventing necrotizing Enterocolitis and related
mortality: Results from an umbrella meta-analysis on meta-analyses of randomized controlled
trials
The authors aim to assess the effects of different types of probiotics on NEC and related
mortality.
Good things about the paper
1 The topic of this paper has a strong application value, the collection of literature materials
is detailed, the comprehensive use of the knowledge to solve the problem, there are innovative
insights. In addition, the paper format is correct, the writing is standardized, clear and fluent.
2 In this paper, the literature on all relevant studies were synthesized, which provided a new
basis. The author's thinking is clear, the process of discussion is rigorous, and the analysis is
reasonable. The writing of the paper is standardized and the sentences are smooth.
Major comments
Although this paper has many advantages, there are still some shortcomings.
1 The risk of bias should be evaluated from six perspectives: measurement bias, attrition bias,
reporting bias, choice bias, performance bias, and other biases. I hope the author can make a
clear analysis from these aspects.
2 In “Literature quality assessment”, what software did you use for the evaluation, and what
were the results of the evaluation? It would be better to provide a corresponding summary chart
or table.
The above are my opinions. I hope the author can explain and modify them. If there are any
shortcomings, I hope the author can criticize and correct me.
Title: The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis
and related mortality: Results from an umbrella meta-analysis on meta-analyses of randomized
controlled trials
Version: 0 Date: 09 Dec 2024
Reviewer:  Gaohong Wu
Reviewer's report:
The effectiveness of treatment with probiotics in preventing necrotizing Enterocolitis and related
mortality: Results from an umbrella meta-analysis on meta-analyses of randomized controlled
trials
The authors aim to assess the effects of different types of probiotics on NEC and related
mortality.
Good things about the paper
1 The topic of this paper has a strong application value, the collection of literature materials
is detailed, the comprehensive use of the knowledge to solve the problem, there are innovative
insights. In addition, the paper format is correct, the writing is standardized, clear and fluent.
2 In this paper, the literature on all relevant studies were synthesized, which provided a new
basis. The author's thinking is clear, the process of discussion is rigorous, and the analysis is
reasonable. The writing of the paper is standardized and the sentences are smooth.
Major comments
Although this paper has many advantages, there are still some shortcomings.
1 The risk of bias should be evaluated from six perspectives: measurement bias, attrition bias,
reporting bias, choice bias, performance bias, and other biases. I hope the author can make a
clear analysis from these aspects.
2 In “Literature quality assessment”, what software did you use for the evaluation, and what
were the results of the evaluation? It would be better to provide a corresponding summary chart
or table.
The above are my opinions. I hope the author can explain and modify them. If there are any
shortcomings, I hope the author can criticize and correct me.
Please review this paper.
user
Title: The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis
and related mortality: Results from an umbrella meta-analysis on meta-analyses of randomized
controlled trials
Version: 0 Date: 09 Dec 2024
Reviewer:  Gaohong Wu
Reviewer's report:
The effectiveness of treatment with probiotics in preventing necrotizing Enterocolitis and related
mortality: Results from an umbrella meta-analysis on meta-analyses of randomized controlled
trials
The authors aim to assess the effects of different types of probiotics on NEC and related
mortality.
Good things about the paper
1 The topic of this paper has a strong application value, the collection of literature materials
is detailed, the comprehensive use of the knowledge to solve the problem, there are innovative
insights. In addition, the paper format is correct, the writing is standardized, clear and fluent.
2 In this paper, the literature on all relevant studies were synthesized, which provided a new
basis. The author's thinking is clear, the process of discussion is rigorous, and the analysis is
reasonable. The writing of the paper is standardized and the sentences are smooth.
Major comments
Although this paper has many advantages, there are still some shortcomings.
1 The risk of bias should be evaluated from six perspectives: measurement bias, attrition bias,
reporting bias, choice bias, performance bias, and other biases. I hope the author can make a
clear analysis from these aspects.
2 In “Literature quality assessment”, what software did you use for the evaluation, and what
were the results of the evaluation? It would be better to provide a corresponding summary chart
or table.
The above are my opinions. I hope the author can explain and modify them. If there are any
shortcomings, I hope the author can criticize and correct me.
assistant