Title: The care cascade for hepatitis C virus and prognosis of chronic hepatitis C patients treated
with antiviral agents in a tertiary hospital
Version: 6 Date: 28 Mar 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Yes, the authors have responded appropriately and adequately to key
queries raised in peer review, and have made corresponding changes to clarify methodology,
interpretatin/discussion, and conclusions.  Overall, the manuscript remains limited due to
intrinsic characteristics as a single-center retrospective cohort study with missing data in several
variables of interest, but otherwise the findings are valid and novel for the specific geography
and study population and does contribute meaningful new data which may help inform public
health and clinical recommendations for this region and is worthy of publication.
REQUESTED REVISIONS:
Overall the objectives, study design, study execution, statistical analysis, and data interpretation
are acceptable.  As requested, the authors have cited important limitations in their dataset and
have clarified specific questions regarding definitions and available/unavailable data in their
cohort.
ADDITIONAL REQUESTS/SUGGESTIONS:
There are still intrinsic non-modifiable limitations and weaknesses in their manuscript due
to retrospective cohort study design and available data, but in this context, the authors
have reasonably reported key findings with clear statement regarding these limitations, and
appropriate conclusions to inform future research studies and clinical practice."
Title: The care cascade for hepatitis C virus and prognosis of chronic hepatitis C patients treated
with antiviral agents in a tertiary hospital
Version: 6 Date: 28 Mar 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Yes, the authors have responded appropriately and adequately to key
queries raised in peer review, and have made corresponding changes to clarify methodology,
interpretatin/discussion, and conclusions.  Overall, the manuscript remains limited due to
intrinsic characteristics as a single-center retrospective cohort study with missing data in several
variables of interest, but otherwise the findings are valid and novel for the specific geography
and study population and does contribute meaningful new data which may help inform public
health and clinical recommendations for this region and is worthy of publication.
REQUESTED REVISIONS:
Overall the objectives, study design, study execution, statistical analysis, and data interpretation
are acceptable.  As requested, the authors have cited important limitations in their dataset and
have clarified specific questions regarding definitions and available/unavailable data in their
cohort.
ADDITIONAL REQUESTS/SUGGESTIONS:
There are still intrinsic non-modifiable limitations and weaknesses in their manuscript due
to retrospective cohort study design and available data, but in this context, the authors
have reasonably reported key findings with clear statement regarding these limitations, and
appropriate conclusions to inform future research studies and clinical practice."
Please review this paper.
user
Title: The care cascade for hepatitis C virus and prognosis of chronic hepatitis C patients treated
with antiviral agents in a tertiary hospital
Version: 6 Date: 28 Mar 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: Yes, the authors have responded appropriately and adequately to key
queries raised in peer review, and have made corresponding changes to clarify methodology,
interpretatin/discussion, and conclusions.  Overall, the manuscript remains limited due to
intrinsic characteristics as a single-center retrospective cohort study with missing data in several
variables of interest, but otherwise the findings are valid and novel for the specific geography
and study population and does contribute meaningful new data which may help inform public
health and clinical recommendations for this region and is worthy of publication.
REQUESTED REVISIONS:
Overall the objectives, study design, study execution, statistical analysis, and data interpretation
are acceptable.  As requested, the authors have cited important limitations in their dataset and
have clarified specific questions regarding definitions and available/unavailable data in their
cohort.
ADDITIONAL REQUESTS/SUGGESTIONS:
There are still intrinsic non-modifiable limitations and weaknesses in their manuscript due
to retrospective cohort study design and available data, but in this context, the authors
have reasonably reported key findings with clear statement regarding these limitations, and
appropriate conclusions to inform future research studies and clinical practice."
assistant