Title: The nomograph predicting the recurrence of Solid Pseudopapillary Neoplasm of the
Pancreas: a study of the SEER database and a Chinese cohort
Version: 1 Date: 24 Jan 2025
Reviewer:  Yukiyasu Okamura
Reviewer's report:
Thank you for the opportunity to review a manuscript entitled "The nomograph predicting the
recurrence of Solid Pseudopapillary Neoplasm of the Pancreas: a study of the SEER database
and a Chinese cohort” for BMC Gastroenterology.
The manuscript was well written, but I think that the nomogram contains inappropriate factors
for predicting recurrence rate. This is a critical point of this manuscript.
There were several points which should be addressed by authors.
Major comments
1. The nomogram includes the factors for “surgery” and “Chemoradiotherapy”. If surgery is not
performed, the tumor remains in the first place, so isn't the recurrence rate 100%?
Does the factor of “Chemoradiotherapy” mean whether or not chemoradiotherapy was
performed perioperatively?
2. SPN is a low-grade malignant tumor with a relatively low recurrence rate. The authors should
mention how this nomogram can be used in clinical practice in the Discussion section.
3. Synchronous metastasis seems to be a risk factor for recurrence. Why is it listed as NA in
Table 2?
4. The text showed Fig. 5A, but isn't there only one Fig. 5? What are Figure A and Figure B
in the legends in Figure 5?
Minor comments
1. In page 8 line 14, Lymphadenectomy should be shown lymphadenectomy.
Title: The nomograph predicting the recurrence of Solid Pseudopapillary Neoplasm of the
Pancreas: a study of the SEER database and a Chinese cohort
Version: 1 Date: 24 Jan 2025
Reviewer:  Yukiyasu Okamura
Reviewer's report:
Thank you for the opportunity to review a manuscript entitled "The nomograph predicting the
recurrence of Solid Pseudopapillary Neoplasm of the Pancreas: a study of the SEER database
and a Chinese cohort” for BMC Gastroenterology.
The manuscript was well written, but I think that the nomogram contains inappropriate factors
for predicting recurrence rate. This is a critical point of this manuscript.
There were several points which should be addressed by authors.
Major comments
1. The nomogram includes the factors for “surgery” and “Chemoradiotherapy”. If surgery is not
performed, the tumor remains in the first place, so isn't the recurrence rate 100%?
Does the factor of “Chemoradiotherapy” mean whether or not chemoradiotherapy was
performed perioperatively?
2. SPN is a low-grade malignant tumor with a relatively low recurrence rate. The authors should
mention how this nomogram can be used in clinical practice in the Discussion section.
3. Synchronous metastasis seems to be a risk factor for recurrence. Why is it listed as NA in
Table 2?
4. The text showed Fig. 5A, but isn't there only one Fig. 5? What are Figure A and Figure B
in the legends in Figure 5?
Minor comments
1. In page 8 line 14, Lymphadenectomy should be shown lymphadenectomy.
Please review this paper.
user
Title: The nomograph predicting the recurrence of Solid Pseudopapillary Neoplasm of the
Pancreas: a study of the SEER database and a Chinese cohort
Version: 1 Date: 24 Jan 2025
Reviewer:  Yukiyasu Okamura
Reviewer's report:
Thank you for the opportunity to review a manuscript entitled "The nomograph predicting the
recurrence of Solid Pseudopapillary Neoplasm of the Pancreas: a study of the SEER database
and a Chinese cohort” for BMC Gastroenterology.
The manuscript was well written, but I think that the nomogram contains inappropriate factors
for predicting recurrence rate. This is a critical point of this manuscript.
There were several points which should be addressed by authors.
Major comments
1. The nomogram includes the factors for “surgery” and “Chemoradiotherapy”. If surgery is not
performed, the tumor remains in the first place, so isn't the recurrence rate 100%?
Does the factor of “Chemoradiotherapy” mean whether or not chemoradiotherapy was
performed perioperatively?
2. SPN is a low-grade malignant tumor with a relatively low recurrence rate. The authors should
mention how this nomogram can be used in clinical practice in the Discussion section.
3. Synchronous metastasis seems to be a risk factor for recurrence. Why is it listed as NA in
Table 2?
4. The text showed Fig. 5A, but isn't there only one Fig. 5? What are Figure A and Figure B
in the legends in Figure 5?
Minor comments
1. In page 8 line 14, Lymphadenectomy should be shown lymphadenectomy.
assistant