Title: Predicting Severity of Inpatient Acute Cholangitis : Combined Neutrophil-to-
Lymphocyte Ratio and Prognostic Nutritional Index
Version: 6 Date: 09 Dec 2024
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Re: "Predicting Severity of Inpatient Acute Cholangitis: Combined Neutrophil-to-Lymphocyte
Ratio and Prognostic Nutritional Index"
Your manuscript offers an insightful and clinically valuable contribution to understanding and
predicting the severity of acute cholangitis. By integrating inflammatory markers like NLR and
SII with nutritional indices such as PNI and albumin, you propose a practical and effective
Prognostic Nutritional Score (PNS) for clinical stratification.
The revisions made to the manuscript address the feedback provided. The improvements in
the methodology section, particularly regarding the inclusion/exclusion criteria, strengthen the
study’s transparency. Additionally, the discussion contextualizes the findings, particularly the
clinical implications of PNS and its potential integration into routine care.
Strengths
The study introduces an easy-to-use scoring system that can enhance decision-making in acute
cholangitis management.
The methodology and statistical analysis are sound, ensuring robust results.
Clear and well-organized tables and figures effectively communicate the data.
Thank you for your comprehensive response to previous feedback and for this important
contribution to the field of hepatobiliary medicine.
Sincerely,
Title: Predicting Severity of Inpatient Acute Cholangitis : Combined Neutrophil-to-
Lymphocyte Ratio and Prognostic Nutritional Index
Version: 6 Date: 09 Dec 2024
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Re: "Predicting Severity of Inpatient Acute Cholangitis: Combined Neutrophil-to-Lymphocyte
Ratio and Prognostic Nutritional Index"
Your manuscript offers an insightful and clinically valuable contribution to understanding and
predicting the severity of acute cholangitis. By integrating inflammatory markers like NLR and
SII with nutritional indices such as PNI and albumin, you propose a practical and effective
Prognostic Nutritional Score (PNS) for clinical stratification.
The revisions made to the manuscript address the feedback provided. The improvements in
the methodology section, particularly regarding the inclusion/exclusion criteria, strengthen the
study’s transparency. Additionally, the discussion contextualizes the findings, particularly the
clinical implications of PNS and its potential integration into routine care.
Strengths
The study introduces an easy-to-use scoring system that can enhance decision-making in acute
cholangitis management.
The methodology and statistical analysis are sound, ensuring robust results.
Clear and well-organized tables and figures effectively communicate the data.
Thank you for your comprehensive response to previous feedback and for this important
contribution to the field of hepatobiliary medicine.
Sincerely,
Please review this paper.
user
Title: Predicting Severity of Inpatient Acute Cholangitis : Combined Neutrophil-to-
Lymphocyte Ratio and Prognostic Nutritional Index
Version: 6 Date: 09 Dec 2024
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Re: "Predicting Severity of Inpatient Acute Cholangitis: Combined Neutrophil-to-Lymphocyte
Ratio and Prognostic Nutritional Index"
Your manuscript offers an insightful and clinically valuable contribution to understanding and
predicting the severity of acute cholangitis. By integrating inflammatory markers like NLR and
SII with nutritional indices such as PNI and albumin, you propose a practical and effective
Prognostic Nutritional Score (PNS) for clinical stratification.
The revisions made to the manuscript address the feedback provided. The improvements in
the methodology section, particularly regarding the inclusion/exclusion criteria, strengthen the
study’s transparency. Additionally, the discussion contextualizes the findings, particularly the
clinical implications of PNS and its potential integration into routine care.
Strengths
The study introduces an easy-to-use scoring system that can enhance decision-making in acute
cholangitis management.
The methodology and statistical analysis are sound, ensuring robust results.
Clear and well-organized tables and figures effectively communicate the data.
Thank you for your comprehensive response to previous feedback and for this important
contribution to the field of hepatobiliary medicine.
Sincerely,
assistant