Title: Comparison of clinical and pathological features between early-stage gastric-type and
intestinal-type differentiated adenocarcinoma: a retrospective study
Version: 1 Date: 11 Dec 2022
Reviewer's report:
This single-center retrospective study aimed to investigate the relationship between histological
phenotype and clinicopathological features in patients with early gastric cancer undergoing ESD.
The authors concluded that gastric phenotype is associated with deep submucosal invasion and
durability of ESD. Although the large sample size is appreciated, the following comments should
be addressed.
1. The main weakness of this study is the lack of novelty. Several studies already reported the
relationship between gastric phenotype and low creative ESD resection rate.
2. The Second issue is the substantial selection biases. This study should have included mixed-
type and unclassified phenotypes to eliminate the biases as much as possible.
3. Comment on IRB approval and patient consent.
4. Clarify the use of immunostaining to evaluate lymphovascular invasion.
5. The authors should discuss how researchers apply the data of this study in clinical practice.
Title: Comparison of clinical and pathological features between early-stage gastric-type and
intestinal-type differentiated adenocarcinoma: a retrospective study
Version: 1 Date: 11 Dec 2022
Reviewer's report:
This single-center retrospective study aimed to investigate the relationship between histological
phenotype and clinicopathological features in patients with early gastric cancer undergoing ESD.
The authors concluded that gastric phenotype is associated with deep submucosal invasion and
durability of ESD. Although the large sample size is appreciated, the following comments should
be addressed.
1. The main weakness of this study is the lack of novelty. Several studies already reported the
relationship between gastric phenotype and low creative ESD resection rate.
2. The Second issue is the substantial selection biases. This study should have included mixed-
type and unclassified phenotypes to eliminate the biases as much as possible.
3. Comment on IRB approval and patient consent.
4. Clarify the use of immunostaining to evaluate lymphovascular invasion.
5. The authors should discuss how researchers apply the data of this study in clinical practice.
Please review this paper.
user
Title: Comparison of clinical and pathological features between early-stage gastric-type and
intestinal-type differentiated adenocarcinoma: a retrospective study
Version: 1 Date: 11 Dec 2022
Reviewer's report:
This single-center retrospective study aimed to investigate the relationship between histological
phenotype and clinicopathological features in patients with early gastric cancer undergoing ESD.
The authors concluded that gastric phenotype is associated with deep submucosal invasion and
durability of ESD. Although the large sample size is appreciated, the following comments should
be addressed.
1. The main weakness of this study is the lack of novelty. Several studies already reported the
relationship between gastric phenotype and low creative ESD resection rate.
2. The Second issue is the substantial selection biases. This study should have included mixed-
type and unclassified phenotypes to eliminate the biases as much as possible.
3. Comment on IRB approval and patient consent.
4. Clarify the use of immunostaining to evaluate lymphovascular invasion.
5. The authors should discuss how researchers apply the data of this study in clinical practice.
assistant