Reviewer's report
Title:Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism
influences the susceptibility to gastric cancer in the Japanese population
Version: 3Date:17 December 2008
Reviewer: caspar grond-ginsbach
Reviewer's report:
Minor revisions:
1. The suggestion of the authors that the genetic variant of SEPS1 is related to
the risk for GC in the Japanese population requires the analysis of a control
group from the healthy population. The authors explained in their answer to this
comment that they analyzed a series of volunteers and their the findings in this
healthy control group suggested them that the comparison between the two
patients groups permitted the analysis of the association between SEPS1 and
the risk of GC. Perhaps the authors can mention the findings in their small control
group of volunteers (as data not shown) and discuss this point shortly in the text.
2. Methods section, page 8. Please change:
....Hospital in Japan. Enrolled subjects were undergone upper .....
into
....Hospital in Japan. Consecutively enrolled subjects underwent upper
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism
influences the susceptibility to gastric cancer in the Japanese population
Version: 3Date:17 December 2008
Reviewer: caspar grond-ginsbach
Reviewer's report:
Minor revisions:
1. The suggestion of the authors that the genetic variant of SEPS1 is related to
the risk for GC in the Japanese population requires the analysis of a control
group from the healthy population. The authors explained in their answer to this
comment that they analyzed a series of volunteers and their the findings in this
healthy control group suggested them that the comparison between the two
patients groups permitted the analysis of the association between SEPS1 and
the risk of GC. Perhaps the authors can mention the findings in their small control
group of volunteers (as data not shown) and discuss this point shortly in the text.
2. Methods section, page 8. Please change:
....Hospital in Japan. Enrolled subjects were undergone upper .....
into
....Hospital in Japan. Consecutively enrolled subjects underwent upper
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism
influences the susceptibility to gastric cancer in the Japanese population
Version: 3Date:17 December 2008
Reviewer: caspar grond-ginsbach
Reviewer's report:
Minor revisions:
1. The suggestion of the authors that the genetic variant of SEPS1 is related to
the risk for GC in the Japanese population requires the analysis of a control
group from the healthy population. The authors explained in their answer to this
comment that they analyzed a series of volunteers and their the findings in this
healthy control group suggested them that the comparison between the two
patients groups permitted the analysis of the association between SEPS1 and
the risk of GC. Perhaps the authors can mention the findings in their small control
group of volunteers (as data not shown) and discuss this point shortly in the text.
2. Methods section, page 8. Please change:
....Hospital in Japan. Enrolled subjects were undergone upper .....
into
....Hospital in Japan. Consecutively enrolled subjects underwent upper
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant