Reviewer's report
Title:Polymyositis complicating pancreatic adenocarcinoma treated with
corticosteroids along with cancer specific treatment: case report
Version: 1Date:23 December 2010
Reviewer: Kiet Phong Tiev
Reviewer's report:
I have a major comment on this observation:
The authors used Peter and Bohan criteria to define the polymyositis. these
criteria overestimated the diagnosis of polymyositis. Recent knowledge on the
pathogenesis of inflammatory myopathies provided some immunochemistry
markers, that may help to differentiate polymyositis from dermatomyositis. It is
better to define polymyositis according to European Neuro Muscular Center
criteria (2004). Therefore, the authors must provide immunochemistry findings of
muscle biopsy (CD8, MHCI, and membrane attack complex).
As this present observation looks like that reported by Ardavanis et al. in
Anticancer
Res 2005, 25(1B):523-525. The authors need to show the immunological
features of the myositis, that will differentiate this present observation from the
previous one.
Reviewer's report
Title:Polymyositis complicating pancreatic adenocarcinoma treated with
corticosteroids along with cancer specific treatment: case report
Version: 1Date:23 December 2010
Reviewer: Kiet Phong Tiev
Reviewer's report:
I have a major comment on this observation:
The authors used Peter and Bohan criteria to define the polymyositis. these
criteria overestimated the diagnosis of polymyositis. Recent knowledge on the
pathogenesis of inflammatory myopathies provided some immunochemistry
markers, that may help to differentiate polymyositis from dermatomyositis. It is
better to define polymyositis according to European Neuro Muscular Center
criteria (2004). Therefore, the authors must provide immunochemistry findings of
muscle biopsy (CD8, MHCI, and membrane attack complex).
As this present observation looks like that reported by Ardavanis et al. in
Anticancer
Res 2005, 25(1B):523-525. The authors need to show the immunological
features of the myositis, that will differentiate this present observation from the
previous one.
Please review this paper.
user
Reviewer's report
Title:Polymyositis complicating pancreatic adenocarcinoma treated with
corticosteroids along with cancer specific treatment: case report
Version: 1Date:23 December 2010
Reviewer: Kiet Phong Tiev
Reviewer's report:
I have a major comment on this observation:
The authors used Peter and Bohan criteria to define the polymyositis. these
criteria overestimated the diagnosis of polymyositis. Recent knowledge on the
pathogenesis of inflammatory myopathies provided some immunochemistry
markers, that may help to differentiate polymyositis from dermatomyositis. It is
better to define polymyositis according to European Neuro Muscular Center
criteria (2004). Therefore, the authors must provide immunochemistry findings of
muscle biopsy (CD8, MHCI, and membrane attack complex).
As this present observation looks like that reported by Ardavanis et al. in
Anticancer
Res 2005, 25(1B):523-525. The authors need to show the immunological
features of the myositis, that will differentiate this present observation from the
previous one.
assistant