Reviewer's report
Title:Combination therapy of infliximab and thalidomide for refractory
entero-Behcet's disease: a case report
Version: 3Date:6 October 2013
Reviewer: Harry Xia Xia
Reviewer's report:
This case report presents a case with refractory entero-Behcet’s disease which
was successfully treated with combination of infliximab and thalidomide. The
report adds new knowledge or experience in the management of the disease.
The manuscript is generally fairly written; some minor modifications are needed.
Minor Essential comments:
1. Abstract: Case presentation needs to be more detailed. For example, the
demographic and clinical information should be described. The term
“gastrointestinal Behcet’s disease” needs to be mentioned in the main text, and
may be removed in the Abstract, even if defined in the main text.
2. Introduction: Specific data and supporting references should be provided for
“along the ancient Silk Route”, and “with severe morbidity and considerable
mortality”. Suggest moving and incorporating the data and references described
in the Discussion to the Introduction.
3. Case presentation”: You mentioned in one place that “PET/CT found multiple
and flake concentration around the jejunum and ileum”, but later that “PET/CT
did not reveal abnormal concentrations nor increased metabolism, ….”. This is
unclear to me. Please clarify.
4. Table 1 actually is a figure.
5. Discussion should focus on the diagnosis and treatment of the disease, based
on your successful case, such as lesions to be learnt, experience to be shared
and recommendation.
6. Use abbreviations correctly. No abbreviations are needed for those terms that
are not to be used later in the main text.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Combination therapy of infliximab and thalidomide for refractory
entero-Behcet's disease: a case report
Version: 3Date:6 October 2013
Reviewer: Harry Xia Xia
Reviewer's report:
This case report presents a case with refractory entero-Behcet’s disease which
was successfully treated with combination of infliximab and thalidomide. The
report adds new knowledge or experience in the management of the disease.
The manuscript is generally fairly written; some minor modifications are needed.
Minor Essential comments:
1. Abstract: Case presentation needs to be more detailed. For example, the
demographic and clinical information should be described. The term
“gastrointestinal Behcet’s disease” needs to be mentioned in the main text, and
may be removed in the Abstract, even if defined in the main text.
2. Introduction: Specific data and supporting references should be provided for
“along the ancient Silk Route”, and “with severe morbidity and considerable
mortality”. Suggest moving and incorporating the data and references described
in the Discussion to the Introduction.
3. Case presentation”: You mentioned in one place that “PET/CT found multiple
and flake concentration around the jejunum and ileum”, but later that “PET/CT
did not reveal abnormal concentrations nor increased metabolism, ….”. This is
unclear to me. Please clarify.
4. Table 1 actually is a figure.
5. Discussion should focus on the diagnosis and treatment of the disease, based
on your successful case, such as lesions to be learnt, experience to be shared
and recommendation.
6. Use abbreviations correctly. No abbreviations are needed for those terms that
are not to be used later in the main text.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Combination therapy of infliximab and thalidomide for refractory
entero-Behcet's disease: a case report
Version: 3Date:6 October 2013
Reviewer: Harry Xia Xia
Reviewer's report:
This case report presents a case with refractory entero-Behcet’s disease which
was successfully treated with combination of infliximab and thalidomide. The
report adds new knowledge or experience in the management of the disease.
The manuscript is generally fairly written; some minor modifications are needed.
Minor Essential comments:
1. Abstract: Case presentation needs to be more detailed. For example, the
demographic and clinical information should be described. The term
“gastrointestinal Behcet’s disease” needs to be mentioned in the main text, and
may be removed in the Abstract, even if defined in the main text.
2. Introduction: Specific data and supporting references should be provided for
“along the ancient Silk Route”, and “with severe morbidity and considerable
mortality”. Suggest moving and incorporating the data and references described
in the Discussion to the Introduction.
3. Case presentation”: You mentioned in one place that “PET/CT found multiple
and flake concentration around the jejunum and ileum”, but later that “PET/CT
did not reveal abnormal concentrations nor increased metabolism, ….”. This is
unclear to me. Please clarify.
4. Table 1 actually is a figure.
5. Discussion should focus on the diagnosis and treatment of the disease, based
on your successful case, such as lesions to be learnt, experience to be shared
and recommendation.
6. Use abbreviations correctly. No abbreviations are needed for those terms that
are not to be used later in the main text.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant