Title: Steroid-mediated liver steatosis is CD1d-dependent while steroid-induced liver necrosis,
inflammation, and metabolic changes are CD1d-independent
Version: 2 Date: 05 Feb 2022
Reviewer's report:
1,  the label of the graphs should be consistent if  they are the  mesurements for the same
motabolic parameters;
2, Page 5,  in significance statement, the spelling of the 2nd "Steroid" missed a "t".
3, in the text , it saids group A,B, C and group D,E,F are the same, but in the table  shows  8
weeks and 12 weeks  respectively;
4, Figure 3B , the Y-axies label  0-600, maybe better 0-500, same as Figure 2B and Figure 1B,
these three graphs should be plotted more consistent.
5,  Figure 2G, there is huge error bar ,  is this really reliable to say GC function from this? maybe
show the hepatic TG content bar data of group A,B,C also?
6, Also Figure 3F  show the GC 's function  on reducing the steroid -mediated steatosis, but the
orally administered steroids  not increased the hepatic TG content in  both wild type and the
CD-/- mice.  not sure if this is enough to get the conclusion.
Title: Steroid-mediated liver steatosis is CD1d-dependent while steroid-induced liver necrosis,
inflammation, and metabolic changes are CD1d-independent
Version: 2 Date: 05 Feb 2022
Reviewer's report:
1,  the label of the graphs should be consistent if  they are the  mesurements for the same
motabolic parameters;
2, Page 5,  in significance statement, the spelling of the 2nd "Steroid" missed a "t".
3, in the text , it saids group A,B, C and group D,E,F are the same, but in the table  shows  8
weeks and 12 weeks  respectively;
4, Figure 3B , the Y-axies label  0-600, maybe better 0-500, same as Figure 2B and Figure 1B,
these three graphs should be plotted more consistent.
5,  Figure 2G, there is huge error bar ,  is this really reliable to say GC function from this? maybe
show the hepatic TG content bar data of group A,B,C also?
6, Also Figure 3F  show the GC 's function  on reducing the steroid -mediated steatosis, but the
orally administered steroids  not increased the hepatic TG content in  both wild type and the
CD-/- mice.  not sure if this is enough to get the conclusion.
Please review this paper.
user
Title: Steroid-mediated liver steatosis is CD1d-dependent while steroid-induced liver necrosis,
inflammation, and metabolic changes are CD1d-independent
Version: 2 Date: 05 Feb 2022
Reviewer's report:
1,  the label of the graphs should be consistent if  they are the  mesurements for the same
motabolic parameters;
2, Page 5,  in significance statement, the spelling of the 2nd "Steroid" missed a "t".
3, in the text , it saids group A,B, C and group D,E,F are the same, but in the table  shows  8
weeks and 12 weeks  respectively;
4, Figure 3B , the Y-axies label  0-600, maybe better 0-500, same as Figure 2B and Figure 1B,
these three graphs should be plotted more consistent.
5,  Figure 2G, there is huge error bar ,  is this really reliable to say GC function from this? maybe
show the hepatic TG content bar data of group A,B,C also?
6, Also Figure 3F  show the GC 's function  on reducing the steroid -mediated steatosis, but the
orally administered steroids  not increased the hepatic TG content in  both wild type and the
CD-/- mice.  not sure if this is enough to get the conclusion.
assistant