Title: Comprehensive Evaluation of Immunological Attributes and Immunotherapy Responses
of Positive T Cell Function Regulators in Colorectal Cancer
Version: 3 Date: 28 Aug 2024
Reviewer's report:
This study examines the role of positive T-cell function regulators (PTFRs) in colorectal cancer
(CRC), identifying 33 top-ranked PTFRs that enhance the proliferation and activation of CD4+
and CD8+ T-cells. The authors utilized comprehensive bioinformatics analyses to demonstrate
these PTFRs' impact on immune cell function, including the secretion of cytokines and resistance
to T-cell exhaustion. The study suggests that overexpression of these genes could improve the
efficacy of CAR-T cell therapies by mitigating exhaustion and enhancing antitumor activity.
The study is commendable for its innovative approach and thorough bioinformatics analyses,
which provide valuable insights into the potential of PTFRs in enhancing immunotherapy
outcomes. However, the absence of an appropriate training and validation cohort raises concerns
about the robustness of the proposed prognostic implications. While the bioinformatics analysis
is strong, further experimental validation, such as RT-PCR, is needed to solidify the findings.
Overall, the research presents meaningful contributions to the understanding of PTFRs in CRC
and could be considered for publication in BMC Gastroenterology, where it would serve as a
valuable resource for researchers in the field.
Title: Comprehensive Evaluation of Immunological Attributes and Immunotherapy Responses
of Positive T Cell Function Regulators in Colorectal Cancer
Version: 3 Date: 28 Aug 2024
Reviewer's report:
This study examines the role of positive T-cell function regulators (PTFRs) in colorectal cancer
(CRC), identifying 33 top-ranked PTFRs that enhance the proliferation and activation of CD4+
and CD8+ T-cells. The authors utilized comprehensive bioinformatics analyses to demonstrate
these PTFRs' impact on immune cell function, including the secretion of cytokines and resistance
to T-cell exhaustion. The study suggests that overexpression of these genes could improve the
efficacy of CAR-T cell therapies by mitigating exhaustion and enhancing antitumor activity.
The study is commendable for its innovative approach and thorough bioinformatics analyses,
which provide valuable insights into the potential of PTFRs in enhancing immunotherapy
outcomes. However, the absence of an appropriate training and validation cohort raises concerns
about the robustness of the proposed prognostic implications. While the bioinformatics analysis
is strong, further experimental validation, such as RT-PCR, is needed to solidify the findings.
Overall, the research presents meaningful contributions to the understanding of PTFRs in CRC
and could be considered for publication in BMC Gastroenterology, where it would serve as a
valuable resource for researchers in the field.
Please review this paper.
user
Title: Comprehensive Evaluation of Immunological Attributes and Immunotherapy Responses
of Positive T Cell Function Regulators in Colorectal Cancer
Version: 3 Date: 28 Aug 2024
Reviewer's report:
This study examines the role of positive T-cell function regulators (PTFRs) in colorectal cancer
(CRC), identifying 33 top-ranked PTFRs that enhance the proliferation and activation of CD4+
and CD8+ T-cells. The authors utilized comprehensive bioinformatics analyses to demonstrate
these PTFRs' impact on immune cell function, including the secretion of cytokines and resistance
to T-cell exhaustion. The study suggests that overexpression of these genes could improve the
efficacy of CAR-T cell therapies by mitigating exhaustion and enhancing antitumor activity.
The study is commendable for its innovative approach and thorough bioinformatics analyses,
which provide valuable insights into the potential of PTFRs in enhancing immunotherapy
outcomes. However, the absence of an appropriate training and validation cohort raises concerns
about the robustness of the proposed prognostic implications. While the bioinformatics analysis
is strong, further experimental validation, such as RT-PCR, is needed to solidify the findings.
Overall, the research presents meaningful contributions to the understanding of PTFRs in CRC
and could be considered for publication in BMC Gastroenterology, where it would serve as a
valuable resource for researchers in the field.
assistant