Title: Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis
Version: 1 Date: 11 Nov 2022
Reviewer:  Endre Anderssen
Reviewer's report:
This is an interesting study of the possible role of cricular RNAs in the inflammatory process
involved in UC. The authors show downregulation of a selected circular RNA in active UC, and
follow this up with an in vitro study using LPS stimulation of CaCo cells as a model for the
inflammatory process.
The model results are consisten with the circular RNA having a possible anti inflammatory
regulatory effect, mediated by interactions with a microRNA. However the conclusion that the
circular RNA CCND1 represses UC processes seems a bridge to far based on only observatio
of differential expression and stimulation studies in a cancer cell line. The results are intriguing
but an effect on UC as opposed to a cell line model has not been shown.
Tho the sience appears sound the paper is very poorly written with many grammar problems and
poor choices of words and should be edited by an english speaker.
Title: Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis
Version: 1 Date: 11 Nov 2022
Reviewer:  Endre Anderssen
Reviewer's report:
This is an interesting study of the possible role of cricular RNAs in the inflammatory process
involved in UC. The authors show downregulation of a selected circular RNA in active UC, and
follow this up with an in vitro study using LPS stimulation of CaCo cells as a model for the
inflammatory process.
The model results are consisten with the circular RNA having a possible anti inflammatory
regulatory effect, mediated by interactions with a microRNA. However the conclusion that the
circular RNA CCND1 represses UC processes seems a bridge to far based on only observatio
of differential expression and stimulation studies in a cancer cell line. The results are intriguing
but an effect on UC as opposed to a cell line model has not been shown.
Tho the sience appears sound the paper is very poorly written with many grammar problems and
poor choices of words and should be edited by an english speaker.
Please review this paper.
user
Title: Protective role of circRNA CCND1 in ulcerative colitis via miR-142-5p/NCOA3 axis
Version: 1 Date: 11 Nov 2022
Reviewer:  Endre Anderssen
Reviewer's report:
This is an interesting study of the possible role of cricular RNAs in the inflammatory process
involved in UC. The authors show downregulation of a selected circular RNA in active UC, and
follow this up with an in vitro study using LPS stimulation of CaCo cells as a model for the
inflammatory process.
The model results are consisten with the circular RNA having a possible anti inflammatory
regulatory effect, mediated by interactions with a microRNA. However the conclusion that the
circular RNA CCND1 represses UC processes seems a bridge to far based on only observatio
of differential expression and stimulation studies in a cancer cell line. The results are intriguing
but an effect on UC as opposed to a cell line model has not been shown.
Tho the sience appears sound the paper is very poorly written with many grammar problems and
poor choices of words and should be edited by an english speaker.
assistant