Title: Deep muscularis propria tumor invasion without lymph node metastasis as a unique
subclassification of stage IB gastric cancer: a retrospective study
Version: 3 Date: 16 Oct 2021
Reviewer's report:
Major points
The main purpose of this study should be described in the Abstract section.
In the Discussion section, it is described that the dMPN0 patients should receive appropriate
adjuvant chemotherapy. However, it is described in the Methods section "The decision as to
whether patients received postoperative adjuvant chemotherapy depended on the integrated
evaluation of pathological examination, therapy guideline and patient intention." Is there any
possibility that patients who did not receive adjuvant chemotherapy tended to have severe
morbidity and were unable to receive adjuvant chemotherapy as compared to those who did
receive adjuvant chemotherapy?
In the Discussion section, it is described that dMPN0 patients (stage IB) with positive expression
of p53 should accept suitable adjuvant chemotherapy like patients in stage II. However, no data
was presented regarding the prognosis of patients with p53+ dMPN0 who did or did not receive
adjuvant chemotherapy.
Minor points
Please provide example pictures of sMP and dMP.
Please provide representative pictures of immunohistochemical staining interpreted as positive
and negative for all the molecular markers investigated.
Please provide in the Methods section how to decide the factors to be used in multivariate
analysis for OS
Please provide the Kaplan-Meyer curves for sMPN1-2 group according to the status of adjuvant
chemotherapy.
Please provide the number of patients analyzed at each month below all the graphs with Kaplan-
Meir curves.
Please delete the first paragraph in the Discussion section because of the duplication with the
Introduction section.
Please cite relevant articles after the sentence " patients with stage II, rather than with stage IB,
should receive the adjuvant chemotherapy depending on therapy guideline" in the Discussion
section.
Title: Deep muscularis propria tumor invasion without lymph node metastasis as a unique
subclassification of stage IB gastric cancer: a retrospective study
Version: 3 Date: 16 Oct 2021
Reviewer's report:
Major points
The main purpose of this study should be described in the Abstract section.
In the Discussion section, it is described that the dMPN0 patients should receive appropriate
adjuvant chemotherapy. However, it is described in the Methods section "The decision as to
whether patients received postoperative adjuvant chemotherapy depended on the integrated
evaluation of pathological examination, therapy guideline and patient intention." Is there any
possibility that patients who did not receive adjuvant chemotherapy tended to have severe
morbidity and were unable to receive adjuvant chemotherapy as compared to those who did
receive adjuvant chemotherapy?
In the Discussion section, it is described that dMPN0 patients (stage IB) with positive expression
of p53 should accept suitable adjuvant chemotherapy like patients in stage II. However, no data
was presented regarding the prognosis of patients with p53+ dMPN0 who did or did not receive
adjuvant chemotherapy.
Minor points
Please provide example pictures of sMP and dMP.
Please provide representative pictures of immunohistochemical staining interpreted as positive
and negative for all the molecular markers investigated.
Please provide in the Methods section how to decide the factors to be used in multivariate
analysis for OS
Please provide the Kaplan-Meyer curves for sMPN1-2 group according to the status of adjuvant
chemotherapy.
Please provide the number of patients analyzed at each month below all the graphs with Kaplan-
Meir curves.
Please delete the first paragraph in the Discussion section because of the duplication with the
Introduction section.
Please cite relevant articles after the sentence " patients with stage II, rather than with stage IB,
should receive the adjuvant chemotherapy depending on therapy guideline" in the Discussion
section.
Please review this paper.
user
Title: Deep muscularis propria tumor invasion without lymph node metastasis as a unique
subclassification of stage IB gastric cancer: a retrospective study
Version: 3 Date: 16 Oct 2021
Reviewer's report:
Major points
The main purpose of this study should be described in the Abstract section.
In the Discussion section, it is described that the dMPN0 patients should receive appropriate
adjuvant chemotherapy. However, it is described in the Methods section "The decision as to
whether patients received postoperative adjuvant chemotherapy depended on the integrated
evaluation of pathological examination, therapy guideline and patient intention." Is there any
possibility that patients who did not receive adjuvant chemotherapy tended to have severe
morbidity and were unable to receive adjuvant chemotherapy as compared to those who did
receive adjuvant chemotherapy?
In the Discussion section, it is described that dMPN0 patients (stage IB) with positive expression
of p53 should accept suitable adjuvant chemotherapy like patients in stage II. However, no data
was presented regarding the prognosis of patients with p53+ dMPN0 who did or did not receive
adjuvant chemotherapy.
Minor points
Please provide example pictures of sMP and dMP.
Please provide representative pictures of immunohistochemical staining interpreted as positive
and negative for all the molecular markers investigated.
Please provide in the Methods section how to decide the factors to be used in multivariate
analysis for OS
Please provide the Kaplan-Meyer curves for sMPN1-2 group according to the status of adjuvant
chemotherapy.
Please provide the number of patients analyzed at each month below all the graphs with Kaplan-
Meir curves.
Please delete the first paragraph in the Discussion section because of the duplication with the
Introduction section.
Please cite relevant articles after the sentence " patients with stage II, rather than with stage IB,
should receive the adjuvant chemotherapy depending on therapy guideline" in the Discussion
section.
assistant