Title: Helicobacter pylori infection is associated with reduced risk of Barrett’s esophagus: A
meta-analysis and systematic review
Version: 0 Date: 11 Sep 2021
Reviewer's report:
This study is a meta-analysis and systematic review about the BE and HP infection. The authors
included the published papers and then they performed meta-analysis, including sub-group
analysis. They concluded that  Hp, especially the CagA-positive Hp strain, and BE are inversely
related with considerable heterogeneity. Of course, there have been several meta-analysis about
the similar subjects and they also suggested the similar conclusion. Nevertheless, this study has
strengths such as additional analysis about cagA positivity, length of BE, and HP eradication or
not. Therefore, this study will give a valuable information on understanding the association of
BE and HP infection to clinicians.
Title: Helicobacter pylori infection is associated with reduced risk of Barrett’s esophagus: A
meta-analysis and systematic review
Version: 0 Date: 11 Sep 2021
Reviewer's report:
This study is a meta-analysis and systematic review about the BE and HP infection. The authors
included the published papers and then they performed meta-analysis, including sub-group
analysis. They concluded that  Hp, especially the CagA-positive Hp strain, and BE are inversely
related with considerable heterogeneity. Of course, there have been several meta-analysis about
the similar subjects and they also suggested the similar conclusion. Nevertheless, this study has
strengths such as additional analysis about cagA positivity, length of BE, and HP eradication or
not. Therefore, this study will give a valuable information on understanding the association of
BE and HP infection to clinicians.
Please review this paper.
user
Title: Helicobacter pylori infection is associated with reduced risk of Barrett’s esophagus: A
meta-analysis and systematic review
Version: 0 Date: 11 Sep 2021
Reviewer's report:
This study is a meta-analysis and systematic review about the BE and HP infection. The authors
included the published papers and then they performed meta-analysis, including sub-group
analysis. They concluded that  Hp, especially the CagA-positive Hp strain, and BE are inversely
related with considerable heterogeneity. Of course, there have been several meta-analysis about
the similar subjects and they also suggested the similar conclusion. Nevertheless, this study has
strengths such as additional analysis about cagA positivity, length of BE, and HP eradication or
not. Therefore, this study will give a valuable information on understanding the association of
BE and HP infection to clinicians.
assistant