Title: Prognostic clinical indexes for prediction of acute gangrenous cholecystitis and acute
purulent cholecystitis
Version: 7 Date: 05 Oct 2022
Reviewer:  Ahmed Nassar
Reviewer's report:
Thank you for re-submitting your manuscript. I have the following comments:
1- In your methods , you mentioned that all emergency cases had contraindication for drainage
and so, had emergency surgery. What was your hospital's policy in management of acute
cholecystitis (like trial with antibiotics first)? is drainage the first option for all cases? What are
the indication for intervention (either drainage or surgery) in your hospital . can you also refer
to Tokyo guidelines regarding this. Was there any attempted failed drainage and hence need for
surgery? Can you please clarify this?
2- Can you add duration of acute symptoms for 3 groups? this may affect US findings
3- Would you be able to specify at what time points routine blood examination (RBE) and US
were performed. were these done at similar intervals for all 3 groups?
Title: Prognostic clinical indexes for prediction of acute gangrenous cholecystitis and acute
purulent cholecystitis
Version: 7 Date: 05 Oct 2022
Reviewer:  Ahmed Nassar
Reviewer's report:
Thank you for re-submitting your manuscript. I have the following comments:
1- In your methods , you mentioned that all emergency cases had contraindication for drainage
and so, had emergency surgery. What was your hospital's policy in management of acute
cholecystitis (like trial with antibiotics first)? is drainage the first option for all cases? What are
the indication for intervention (either drainage or surgery) in your hospital . can you also refer
to Tokyo guidelines regarding this. Was there any attempted failed drainage and hence need for
surgery? Can you please clarify this?
2- Can you add duration of acute symptoms for 3 groups? this may affect US findings
3- Would you be able to specify at what time points routine blood examination (RBE) and US
were performed. were these done at similar intervals for all 3 groups?
Please review this paper.
user
Title: Prognostic clinical indexes for prediction of acute gangrenous cholecystitis and acute
purulent cholecystitis
Version: 7 Date: 05 Oct 2022
Reviewer:  Ahmed Nassar
Reviewer's report:
Thank you for re-submitting your manuscript. I have the following comments:
1- In your methods , you mentioned that all emergency cases had contraindication for drainage
and so, had emergency surgery. What was your hospital's policy in management of acute
cholecystitis (like trial with antibiotics first)? is drainage the first option for all cases? What are
the indication for intervention (either drainage or surgery) in your hospital . can you also refer
to Tokyo guidelines regarding this. Was there any attempted failed drainage and hence need for
surgery? Can you please clarify this?
2- Can you add duration of acute symptoms for 3 groups? this may affect US findings
3- Would you be able to specify at what time points routine blood examination (RBE) and US
were performed. were these done at similar intervals for all 3 groups?
assistant