Reviewer's report
Title:Impact of a probiotic fermented milk in the gut ecosystem and in the
systemic immunity using a non-sever protein-energy-malnutrition model in mice
Version: 1Date:22 December 2010
Reviewer: HARIOM YADAV
Reviewer's report:
Galdeano and colleagues reported the immunomodulatory effects of probiotic
fermented milk in non-severe protein energy-malnourished mice model. Although
the study is interesting, but before final acception of this article, few
improvements must be made:
1. There are abundant typographical and grammatical errors all over the running
text, which must be corrected carefully
2. Although these findings are interesting in relation with malnutrition, but
probiotics and probiotic containing fermented milk products have shown
health-beneficial effects in high-energy fed animal models (i.e. Yadav et al
Nutrition. 2007 Jan;23(1):62-8, described this effect), and reviewer wonders how
does you explain your findings in reference of high energy induced obesity vs
malnourished animal models.
3. The gut flora has been closely correlated with obesity in recent era, I am
wondering while mice fed with probiotic-fermented milk gained fat mass in
comparison to control mice.
4. Recently Jain et al (J Med Food. 2009 Jun;12(3):576-83) also have reported
that probiotic containing fermented milk product improved immunological
parameters in normal mice, how does your findings are different than Jain et al
findings, please discuss.
Minor points:
1. Please replace ‘sever’ with ‘severe’ in title
2. Abstract: ln 17-21; please complete the sentence
3. Background: ln 34-37; complete/correct the sentence
4. ln 46; insert ‘known’ by replacing ‘know’
5. ln 56; define what is ‘PFM’, or Is that PEM and PFM is the same, if it is than
keep one consistent in whole text
6. Methods: ln 74, replace ‘experience’ with ‘experiments’ and other places too in
the text
7. ln 89; correct temperature
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Impact of a probiotic fermented milk in the gut ecosystem and in the
systemic immunity using a non-sever protein-energy-malnutrition model in mice
Version: 1Date:22 December 2010
Reviewer: HARIOM YADAV
Reviewer's report:
Galdeano and colleagues reported the immunomodulatory effects of probiotic
fermented milk in non-severe protein energy-malnourished mice model. Although
the study is interesting, but before final acception of this article, few
improvements must be made:
1. There are abundant typographical and grammatical errors all over the running
text, which must be corrected carefully
2. Although these findings are interesting in relation with malnutrition, but
probiotics and probiotic containing fermented milk products have shown
health-beneficial effects in high-energy fed animal models (i.e. Yadav et al
Nutrition. 2007 Jan;23(1):62-8, described this effect), and reviewer wonders how
does you explain your findings in reference of high energy induced obesity vs
malnourished animal models.
3. The gut flora has been closely correlated with obesity in recent era, I am
wondering while mice fed with probiotic-fermented milk gained fat mass in
comparison to control mice.
4. Recently Jain et al (J Med Food. 2009 Jun;12(3):576-83) also have reported
that probiotic containing fermented milk product improved immunological
parameters in normal mice, how does your findings are different than Jain et al
findings, please discuss.
Minor points:
1. Please replace ‘sever’ with ‘severe’ in title
2. Abstract: ln 17-21; please complete the sentence
3. Background: ln 34-37; complete/correct the sentence
4. ln 46; insert ‘known’ by replacing ‘know’
5. ln 56; define what is ‘PFM’, or Is that PEM and PFM is the same, if it is than
keep one consistent in whole text
6. Methods: ln 74, replace ‘experience’ with ‘experiments’ and other places too in
the text
7. ln 89; correct temperature
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Impact of a probiotic fermented milk in the gut ecosystem and in the
systemic immunity using a non-sever protein-energy-malnutrition model in mice
Version: 1Date:22 December 2010
Reviewer: HARIOM YADAV
Reviewer's report:
Galdeano and colleagues reported the immunomodulatory effects of probiotic
fermented milk in non-severe protein energy-malnourished mice model. Although
the study is interesting, but before final acception of this article, few
improvements must be made:
1. There are abundant typographical and grammatical errors all over the running
text, which must be corrected carefully
2. Although these findings are interesting in relation with malnutrition, but
probiotics and probiotic containing fermented milk products have shown
health-beneficial effects in high-energy fed animal models (i.e. Yadav et al
Nutrition. 2007 Jan;23(1):62-8, described this effect), and reviewer wonders how
does you explain your findings in reference of high energy induced obesity vs
malnourished animal models.
3. The gut flora has been closely correlated with obesity in recent era, I am
wondering while mice fed with probiotic-fermented milk gained fat mass in
comparison to control mice.
4. Recently Jain et al (J Med Food. 2009 Jun;12(3):576-83) also have reported
that probiotic containing fermented milk product improved immunological
parameters in normal mice, how does your findings are different than Jain et al
findings, please discuss.
Minor points:
1. Please replace ‘sever’ with ‘severe’ in title
2. Abstract: ln 17-21; please complete the sentence
3. Background: ln 34-37; complete/correct the sentence
4. ln 46; insert ‘known’ by replacing ‘know’
5. ln 56; define what is ‘PFM’, or Is that PEM and PFM is the same, if it is than
keep one consistent in whole text
6. Methods: ln 74, replace ‘experience’ with ‘experiments’ and other places too in
the text
7. ln 89; correct temperature
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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