Title: Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of Immune
Checkpoint Inhibitors in Gastric Cancer
Version: 1 Date: 22 Mar 2023
Reviewer's report:
The paper named “Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of
Immune Checkpoint Inhibitors in Gastric Cancer” conducted by Xu et al. has been evaluated. I
think this study has certain innovation and clinical significance. In this study, the author found
that “ITGB1 may be a promising prognostic biomarker and effective predictor for anti-PD1
therapy in GC.”. However, some obvious limitations impair the overall quality. Before it is
suitable for publication, I suggest the author make substantive modifications.
1. I noticed that some of the figures have a low resolution which makes them hard to read. I
would suggest that the authors increase the resolution of these figures, which would make them
easier to read and understand. This would also make it easier for readers to fully understand the
results and make use of it. I believe that increasing the resolution of these figures would greatly
improve the manuscript.
2. Some previous studies have used similar bioinformatics or statistical methods. Although
it will lose some innovation, I think it will benefit the reader if the authors could include
the following references, which would provide readers with a more complete understanding
of the whole study: doi: 10.3389/fgene.2021.680369; doi: 10.1038/s41598-021-87540-0; doi:
10.1038/s41598-022-07070-1; doi: 10.3389/fgene.2021.627508 ....
3. Detailed description of all method sections is required.
4. State the * and statistic value in the method section or otherwise mention in every figure
legend. e.g., *p>0.05.
5. Check the reference style and abbreviation of journals.
6. Some typos are there; rectify those (Major).
7. In fact, ITGB1 has been explored in GC. The author should highlight the innovation of the
article
8. Please evaluated the single-cell expression pattern of ITGB1 in GC microenvironment based
on open-accessed projects like TISCH.
9. Can the author predict the impact of ITGB1 on immunotherapy for gastric cancer using TIDE
algorithm?
Title: Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of Immune
Checkpoint Inhibitors in Gastric Cancer
Version: 1 Date: 22 Mar 2023
Reviewer's report:
The paper named “Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of
Immune Checkpoint Inhibitors in Gastric Cancer” conducted by Xu et al. has been evaluated. I
think this study has certain innovation and clinical significance. In this study, the author found
that “ITGB1 may be a promising prognostic biomarker and effective predictor for anti-PD1
therapy in GC.”. However, some obvious limitations impair the overall quality. Before it is
suitable for publication, I suggest the author make substantive modifications.
1. I noticed that some of the figures have a low resolution which makes them hard to read. I
would suggest that the authors increase the resolution of these figures, which would make them
easier to read and understand. This would also make it easier for readers to fully understand the
results and make use of it. I believe that increasing the resolution of these figures would greatly
improve the manuscript.
2. Some previous studies have used similar bioinformatics or statistical methods. Although
it will lose some innovation, I think it will benefit the reader if the authors could include
the following references, which would provide readers with a more complete understanding
of the whole study: doi: 10.3389/fgene.2021.680369; doi: 10.1038/s41598-021-87540-0; doi:
10.1038/s41598-022-07070-1; doi: 10.3389/fgene.2021.627508 ....
3. Detailed description of all method sections is required.
4. State the * and statistic value in the method section or otherwise mention in every figure
legend. e.g., *p>0.05.
5. Check the reference style and abbreviation of journals.
6. Some typos are there; rectify those (Major).
7. In fact, ITGB1 has been explored in GC. The author should highlight the innovation of the
article
8. Please evaluated the single-cell expression pattern of ITGB1 in GC microenvironment based
on open-accessed projects like TISCH.
9. Can the author predict the impact of ITGB1 on immunotherapy for gastric cancer using TIDE
algorithm?
Please review this paper.
user
Title: Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of Immune
Checkpoint Inhibitors in Gastric Cancer
Version: 1 Date: 22 Mar 2023
Reviewer's report:
The paper named “Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of
Immune Checkpoint Inhibitors in Gastric Cancer” conducted by Xu et al. has been evaluated. I
think this study has certain innovation and clinical significance. In this study, the author found
that “ITGB1 may be a promising prognostic biomarker and effective predictor for anti-PD1
therapy in GC.”. However, some obvious limitations impair the overall quality. Before it is
suitable for publication, I suggest the author make substantive modifications.
1. I noticed that some of the figures have a low resolution which makes them hard to read. I
would suggest that the authors increase the resolution of these figures, which would make them
easier to read and understand. This would also make it easier for readers to fully understand the
results and make use of it. I believe that increasing the resolution of these figures would greatly
improve the manuscript.
2. Some previous studies have used similar bioinformatics or statistical methods. Although
it will lose some innovation, I think it will benefit the reader if the authors could include
the following references, which would provide readers with a more complete understanding
of the whole study: doi: 10.3389/fgene.2021.680369; doi: 10.1038/s41598-021-87540-0; doi:
10.1038/s41598-022-07070-1; doi: 10.3389/fgene.2021.627508 ....
3. Detailed description of all method sections is required.
4. State the * and statistic value in the method section or otherwise mention in every figure
legend. e.g., *p>0.05.
5. Check the reference style and abbreviation of journals.
6. Some typos are there; rectify those (Major).
7. In fact, ITGB1 has been explored in GC. The author should highlight the innovation of the
article
8. Please evaluated the single-cell expression pattern of ITGB1 in GC microenvironment based
on open-accessed projects like TISCH.
9. Can the author predict the impact of ITGB1 on immunotherapy for gastric cancer using TIDE
algorithm?
assistant