Title: Alcohol increases treatment failure for Helicobacter pylori eradication in Asian
populations
Version: 1 Date: 26 Sep 2023
Reviewer:  Kenta Watanabe
Reviewer's report:
This meta-analysis demonstrated an increased risk of H. pylori eradication failure due to alcohol
consumption in Asian populations. Appropriate subgroup and sensitivity analyses, interpretation
of results, and limitations are mentioned. The writing is convincing and professional. However,
there are some concerns.
1. In the Asian studies, there were seven studies that had data on alcohol intake. In the
case of non-Asian studies, was there any applicable study? If relevant studies exist, the
association between increased alcohol consumption and H. pylori eradication failure in non-
Asian populations should be investigated.
2. In the Asian populations, a >7 days treatment was associated with higher risk of eradication
failure. It seems a little strange that the risk of eradication failure is greater in long-term treatment
than in short. Is there any rationale you can provide regarding this fact?
Title: Alcohol increases treatment failure for Helicobacter pylori eradication in Asian
populations
Version: 1 Date: 26 Sep 2023
Reviewer:  Kenta Watanabe
Reviewer's report:
This meta-analysis demonstrated an increased risk of H. pylori eradication failure due to alcohol
consumption in Asian populations. Appropriate subgroup and sensitivity analyses, interpretation
of results, and limitations are mentioned. The writing is convincing and professional. However,
there are some concerns.
1. In the Asian studies, there were seven studies that had data on alcohol intake. In the
case of non-Asian studies, was there any applicable study? If relevant studies exist, the
association between increased alcohol consumption and H. pylori eradication failure in non-
Asian populations should be investigated.
2. In the Asian populations, a >7 days treatment was associated with higher risk of eradication
failure. It seems a little strange that the risk of eradication failure is greater in long-term treatment
than in short. Is there any rationale you can provide regarding this fact?
Please review this paper.
user
Title: Alcohol increases treatment failure for Helicobacter pylori eradication in Asian
populations
Version: 1 Date: 26 Sep 2023
Reviewer:  Kenta Watanabe
Reviewer's report:
This meta-analysis demonstrated an increased risk of H. pylori eradication failure due to alcohol
consumption in Asian populations. Appropriate subgroup and sensitivity analyses, interpretation
of results, and limitations are mentioned. The writing is convincing and professional. However,
there are some concerns.
1. In the Asian studies, there were seven studies that had data on alcohol intake. In the
case of non-Asian studies, was there any applicable study? If relevant studies exist, the
association between increased alcohol consumption and H. pylori eradication failure in non-
Asian populations should be investigated.
2. In the Asian populations, a >7 days treatment was associated with higher risk of eradication
failure. It seems a little strange that the risk of eradication failure is greater in long-term treatment
than in short. Is there any rationale you can provide regarding this fact?
assistant