Title: Nonlinear Association between AST/ALT Ratio and 28-Day All-Cause Mortality
Following ICU Admission in Critically Ill Cirrhotic Patients: A Retrospective Cohort Study
Version: 1 Date: 31 Mar 2025
Reviewer's report:
The authors should include either a supplemental page describing the ICD codes used to identify
the "cirrhotic" patient population or describe a significant limitation of the study in using ICD
codes to accurately identify the population of interest.
It would be helpful to describe other biomarkers which could suggest AST elevation not due
to  liver injury for example CK or troponin as this would have significant implications for the
interpretation of this data.
Title: Nonlinear Association between AST/ALT Ratio and 28-Day All-Cause Mortality
Following ICU Admission in Critically Ill Cirrhotic Patients: A Retrospective Cohort Study
Version: 1 Date: 31 Mar 2025
Reviewer's report:
The authors should include either a supplemental page describing the ICD codes used to identify
the "cirrhotic" patient population or describe a significant limitation of the study in using ICD
codes to accurately identify the population of interest.
It would be helpful to describe other biomarkers which could suggest AST elevation not due
to  liver injury for example CK or troponin as this would have significant implications for the
interpretation of this data.
Please review this paper.
user
Title: Nonlinear Association between AST/ALT Ratio and 28-Day All-Cause Mortality
Following ICU Admission in Critically Ill Cirrhotic Patients: A Retrospective Cohort Study
Version: 1 Date: 31 Mar 2025
Reviewer's report:
The authors should include either a supplemental page describing the ICD codes used to identify
the "cirrhotic" patient population or describe a significant limitation of the study in using ICD
codes to accurately identify the population of interest.
It would be helpful to describe other biomarkers which could suggest AST elevation not due
to  liver injury for example CK or troponin as this would have significant implications for the
interpretation of this data.
assistant