Reviewer's report
Title:Changes of the T cells-related cytokines on post-infectious irritable bowel
syndrome mouse model
Version:2Date:24 August 2014
Reviewer: Cesare Cremon
Reviewer's report:
This is an interesting study assessing the role of immune mechanism in the
pathophysiology of post-infectious irritable bowel syndrome (PI-IBS). In mice
infected with Trichinella larvae, the authors assessed abdominal withdrawal
reflex (AWR) scores, intestinal histology, and the expression (at day 56
post-infection) of pro- and anti-inflammatory cytokines. The levels of IFN-# and
IL-17 were significantly increased in the duodenum and ileum, while those of
IL-10 were decreased in jejunum, ileum, and colon of PI-IBS vs. control group.
The study appears to be well designed and conducted, and the results are clearly
reported. The discussion is consistent with the results. However, English
language is sometimes poor and needs consistent revision. All the sections
should be thoroughly revised since some mistakes may have occurred.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Changes of the T cells-related cytokines on post-infectious irritable bowel
syndrome mouse model
Version:2Date:24 August 2014
Reviewer: Cesare Cremon
Reviewer's report:
This is an interesting study assessing the role of immune mechanism in the
pathophysiology of post-infectious irritable bowel syndrome (PI-IBS). In mice
infected with Trichinella larvae, the authors assessed abdominal withdrawal
reflex (AWR) scores, intestinal histology, and the expression (at day 56
post-infection) of pro- and anti-inflammatory cytokines. The levels of IFN-# and
IL-17 were significantly increased in the duodenum and ileum, while those of
IL-10 were decreased in jejunum, ileum, and colon of PI-IBS vs. control group.
The study appears to be well designed and conducted, and the results are clearly
reported. The discussion is consistent with the results. However, English
language is sometimes poor and needs consistent revision. All the sections
should be thoroughly revised since some mistakes may have occurred.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Changes of the T cells-related cytokines on post-infectious irritable bowel
syndrome mouse model
Version:2Date:24 August 2014
Reviewer: Cesare Cremon
Reviewer's report:
This is an interesting study assessing the role of immune mechanism in the
pathophysiology of post-infectious irritable bowel syndrome (PI-IBS). In mice
infected with Trichinella larvae, the authors assessed abdominal withdrawal
reflex (AWR) scores, intestinal histology, and the expression (at day 56
post-infection) of pro- and anti-inflammatory cytokines. The levels of IFN-# and
IL-17 were significantly increased in the duodenum and ileum, while those of
IL-10 were decreased in jejunum, ileum, and colon of PI-IBS vs. control group.
The study appears to be well designed and conducted, and the results are clearly
reported. The discussion is consistent with the results. However, English
language is sometimes poor and needs consistent revision. All the sections
should be thoroughly revised since some mistakes may have occurred.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
assistant