Title: Combination of Neutrophil/Lymphocyte Ratio and Albumin/Bilirubin Grade as a
Prognostic Predictor for Hepatocellular Carcinoma Patients Undergoing Curative Hepatectomy
Version: 2 Date: 02 Mar 2023
Reviewer:  Takayuki Shimizu
Reviewer's report:
The authors developed new prognostic score for patients with HCC. This prognostic score
combined tumor behavior with liver functional assessment. This score clearly stratified survival
curve in patients with HCC. Multivariate Cox regression analysis revealed this score was
independent prognostic variable. However, the result section had unnecessary sentences and
Tables, and the discussion section should be revised because your consideration and discussion
is not enough.
In method section, Graphpad software is not the production from IBM.
In result section, Table1, Table2 and Table3 is not necessary because I think the authors show
only the association of NLR-ALBI score with clinicopathological features in HCC patients.
The authors should delete the sentences of “The association of the per-operative NLR with the
clinicopathological features of HCC.” and “The association of the per-operative ALBI with the
clinicopathological features of HCC.”, Table 1, Table 2 and Table 3.
In first paragraph of discussion section, I have no idea why the authors mentioned about
diagnosis and economic burden of HCC. These contents should be written in Introduction
section. Is there any association of HCC diagnosis and economic burden with NLR-ALBI score?
Anyway, the authors delete this first paragraph. The authors should mention the brief summary
of result in first paragraph of discussion section.
In third paragraph of discussion section, the author should refer to the reference as following
sentence; In a systemic review that included 20 studies with 11365 patients, Geng and his
colleagues concluded that higher ALBI was associated with poorer OS.
In forth paragraph of discussion section, the authors revise the following term from “per-
operative” to “pre-operative”.
Do you think how does your new prognostic NLR-ALBI score apply to clinical practice? Is this
new score useful for early intervention of adjuvant therapy or nutritional therapy, evacuation of
invasive surgery? You should consider how does NLR-ALBI score apply to clinical practice in
order to improve patients outcome, and mention your consideration in discussion section.
Title: Combination of Neutrophil/Lymphocyte Ratio and Albumin/Bilirubin Grade as a
Prognostic Predictor for Hepatocellular Carcinoma Patients Undergoing Curative Hepatectomy
Version: 2 Date: 02 Mar 2023
Reviewer:  Takayuki Shimizu
Reviewer's report:
The authors developed new prognostic score for patients with HCC. This prognostic score
combined tumor behavior with liver functional assessment. This score clearly stratified survival
curve in patients with HCC. Multivariate Cox regression analysis revealed this score was
independent prognostic variable. However, the result section had unnecessary sentences and
Tables, and the discussion section should be revised because your consideration and discussion
is not enough.
In method section, Graphpad software is not the production from IBM.
In result section, Table1, Table2 and Table3 is not necessary because I think the authors show
only the association of NLR-ALBI score with clinicopathological features in HCC patients.
The authors should delete the sentences of “The association of the per-operative NLR with the
clinicopathological features of HCC.” and “The association of the per-operative ALBI with the
clinicopathological features of HCC.”, Table 1, Table 2 and Table 3.
In first paragraph of discussion section, I have no idea why the authors mentioned about
diagnosis and economic burden of HCC. These contents should be written in Introduction
section. Is there any association of HCC diagnosis and economic burden with NLR-ALBI score?
Anyway, the authors delete this first paragraph. The authors should mention the brief summary
of result in first paragraph of discussion section.
In third paragraph of discussion section, the author should refer to the reference as following
sentence; In a systemic review that included 20 studies with 11365 patients, Geng and his
colleagues concluded that higher ALBI was associated with poorer OS.
In forth paragraph of discussion section, the authors revise the following term from “per-
operative” to “pre-operative”.
Do you think how does your new prognostic NLR-ALBI score apply to clinical practice? Is this
new score useful for early intervention of adjuvant therapy or nutritional therapy, evacuation of
invasive surgery? You should consider how does NLR-ALBI score apply to clinical practice in
order to improve patients outcome, and mention your consideration in discussion section.
Please review this paper.
user
Title: Combination of Neutrophil/Lymphocyte Ratio and Albumin/Bilirubin Grade as a
Prognostic Predictor for Hepatocellular Carcinoma Patients Undergoing Curative Hepatectomy
Version: 2 Date: 02 Mar 2023
Reviewer:  Takayuki Shimizu
Reviewer's report:
The authors developed new prognostic score for patients with HCC. This prognostic score
combined tumor behavior with liver functional assessment. This score clearly stratified survival
curve in patients with HCC. Multivariate Cox regression analysis revealed this score was
independent prognostic variable. However, the result section had unnecessary sentences and
Tables, and the discussion section should be revised because your consideration and discussion
is not enough.
In method section, Graphpad software is not the production from IBM.
In result section, Table1, Table2 and Table3 is not necessary because I think the authors show
only the association of NLR-ALBI score with clinicopathological features in HCC patients.
The authors should delete the sentences of “The association of the per-operative NLR with the
clinicopathological features of HCC.” and “The association of the per-operative ALBI with the
clinicopathological features of HCC.”, Table 1, Table 2 and Table 3.
In first paragraph of discussion section, I have no idea why the authors mentioned about
diagnosis and economic burden of HCC. These contents should be written in Introduction
section. Is there any association of HCC diagnosis and economic burden with NLR-ALBI score?
Anyway, the authors delete this first paragraph. The authors should mention the brief summary
of result in first paragraph of discussion section.
In third paragraph of discussion section, the author should refer to the reference as following
sentence; In a systemic review that included 20 studies with 11365 patients, Geng and his
colleagues concluded that higher ALBI was associated with poorer OS.
In forth paragraph of discussion section, the authors revise the following term from “per-
operative” to “pre-operative”.
Do you think how does your new prognostic NLR-ALBI score apply to clinical practice? Is this
new score useful for early intervention of adjuvant therapy or nutritional therapy, evacuation of
invasive surgery? You should consider how does NLR-ALBI score apply to clinical practice in
order to improve patients outcome, and mention your consideration in discussion section.
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