Reviewer's report
Title:Schwann cell hamartoma: Case report
Version: 2Date:14 April 2011
Reviewer: Naotaka Ogasawara
Reviewer's report:
Colorectal polyps containing S-100 positive neural proliferations in the lamina
propria that lack ganglion cells have been previously referred to as neuromas or
neurofibromas.
Recently, Gibson analyzed 26 cases of colorectal polyps comprising pure
Schwann cell proliferation, different from gastrointestinal schwannomas and with
no association with inherited syndrome. This entity was designed as mucosal
Schwann cell hamartoma. In this report, the authors investigated a case of
colonic polypoid lesion with features of this recently proposed new entity. The
mucosal Schwann cell hamartoma of gastrointestinal tracts is extremely rare and
informative for other clinicians. Therefore, the reviewer believes that this
manuscript is very interesting and worth being published in the journal. However,
there are the following shortcomings as follows:
Major Compulsory Revisions
1. Authors described that one small polyp which was 3 mm in diameter was
removed at 30 cm-distance from anal rim. Authors should investigate the method
of resection.
2. In this report, authors only showed the pathological findings. For information
and education to endoscopists and other clinicians, authors should indicate the
colonoscopic findings of the polyp features, and investigate the difference
between adenomatous polyp, hyperplastic polyp and mucosal Schwann cell
hamartoma.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Schwann cell hamartoma: Case report
Version: 2Date:14 April 2011
Reviewer: Naotaka Ogasawara
Reviewer's report:
Colorectal polyps containing S-100 positive neural proliferations in the lamina
propria that lack ganglion cells have been previously referred to as neuromas or
neurofibromas.
Recently, Gibson analyzed 26 cases of colorectal polyps comprising pure
Schwann cell proliferation, different from gastrointestinal schwannomas and with
no association with inherited syndrome. This entity was designed as mucosal
Schwann cell hamartoma. In this report, the authors investigated a case of
colonic polypoid lesion with features of this recently proposed new entity. The
mucosal Schwann cell hamartoma of gastrointestinal tracts is extremely rare and
informative for other clinicians. Therefore, the reviewer believes that this
manuscript is very interesting and worth being published in the journal. However,
there are the following shortcomings as follows:
Major Compulsory Revisions
1. Authors described that one small polyp which was 3 mm in diameter was
removed at 30 cm-distance from anal rim. Authors should investigate the method
of resection.
2. In this report, authors only showed the pathological findings. For information
and education to endoscopists and other clinicians, authors should indicate the
colonoscopic findings of the polyp features, and investigate the difference
between adenomatous polyp, hyperplastic polyp and mucosal Schwann cell
hamartoma.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Schwann cell hamartoma: Case report
Version: 2Date:14 April 2011
Reviewer: Naotaka Ogasawara
Reviewer's report:
Colorectal polyps containing S-100 positive neural proliferations in the lamina
propria that lack ganglion cells have been previously referred to as neuromas or
neurofibromas.
Recently, Gibson analyzed 26 cases of colorectal polyps comprising pure
Schwann cell proliferation, different from gastrointestinal schwannomas and with
no association with inherited syndrome. This entity was designed as mucosal
Schwann cell hamartoma. In this report, the authors investigated a case of
colonic polypoid lesion with features of this recently proposed new entity. The
mucosal Schwann cell hamartoma of gastrointestinal tracts is extremely rare and
informative for other clinicians. Therefore, the reviewer believes that this
manuscript is very interesting and worth being published in the journal. However,
there are the following shortcomings as follows:
Major Compulsory Revisions
1. Authors described that one small polyp which was 3 mm in diameter was
removed at 30 cm-distance from anal rim. Authors should investigate the method
of resection.
2. In this report, authors only showed the pathological findings. For information
and education to endoscopists and other clinicians, authors should indicate the
colonoscopic findings of the polyp features, and investigate the difference
between adenomatous polyp, hyperplastic polyp and mucosal Schwann cell
hamartoma.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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