Title: Inflammatory bowel disease increases the risk of pancreatitis: A two-sample bidirectional
mendelian randomization analysis
Version: 1 Date: 06 Oct 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is the review of the manuscript titled "Inflammatory bowel
disease increases the risk of pancreatitis: A two-sample Mendelian randomization analysis".
in this paper authors used Mendelian Randomization (MR) to investigate causality of the
genetic connections between two diseases 1) IBD (Crohn' and Ulcerative colitis subtypes) and
pancreatitis (acute and chronic subtypes). This is interesting MS, which is not written as very
dry technical report. To improve this MS, the following is needed:
1) As in case of acute and chronic pancreatitis the pathophysiology is shared, when one clearly
predisposes to another and there is a mutuality of risk factors,  please expand "Introduction" to
explain this common pathophysiology.
2) in Discussion section, please start with explaining results of a previous MR in details, to tie
these results down to the findings of present study.
3) from statistics standpoint, this MS is executed correctly, but the strength of the findings is
relatively weak (one of three models showed significance). Authors should discuss why they are
sure that found true causal connections; why this model correct but not other.
4) Please compare findings with PMID: 39205942 and PMID: 38847662  and explain what is
different and what is new.
REQUESTED REVISIONS:
please see comments above, especially concerning the novelty (point 4).
ADDITIONAL REQUESTS/SUGGESTIONS:
this is good quality MS, but may be these findings are already reported (please see novelty
concern)
Title: Inflammatory bowel disease increases the risk of pancreatitis: A two-sample bidirectional
mendelian randomization analysis
Version: 1 Date: 06 Oct 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is the review of the manuscript titled "Inflammatory bowel
disease increases the risk of pancreatitis: A two-sample Mendelian randomization analysis".
in this paper authors used Mendelian Randomization (MR) to investigate causality of the
genetic connections between two diseases 1) IBD (Crohn' and Ulcerative colitis subtypes) and
pancreatitis (acute and chronic subtypes). This is interesting MS, which is not written as very
dry technical report. To improve this MS, the following is needed:
1) As in case of acute and chronic pancreatitis the pathophysiology is shared, when one clearly
predisposes to another and there is a mutuality of risk factors,  please expand "Introduction" to
explain this common pathophysiology.
2) in Discussion section, please start with explaining results of a previous MR in details, to tie
these results down to the findings of present study.
3) from statistics standpoint, this MS is executed correctly, but the strength of the findings is
relatively weak (one of three models showed significance). Authors should discuss why they are
sure that found true causal connections; why this model correct but not other.
4) Please compare findings with PMID: 39205942 and PMID: 38847662  and explain what is
different and what is new.
REQUESTED REVISIONS:
please see comments above, especially concerning the novelty (point 4).
ADDITIONAL REQUESTS/SUGGESTIONS:
this is good quality MS, but may be these findings are already reported (please see novelty
concern)
Please review this paper.
user
Title: Inflammatory bowel disease increases the risk of pancreatitis: A two-sample bidirectional
mendelian randomization analysis
Version: 1 Date: 06 Oct 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is the review of the manuscript titled "Inflammatory bowel
disease increases the risk of pancreatitis: A two-sample Mendelian randomization analysis".
in this paper authors used Mendelian Randomization (MR) to investigate causality of the
genetic connections between two diseases 1) IBD (Crohn' and Ulcerative colitis subtypes) and
pancreatitis (acute and chronic subtypes). This is interesting MS, which is not written as very
dry technical report. To improve this MS, the following is needed:
1) As in case of acute and chronic pancreatitis the pathophysiology is shared, when one clearly
predisposes to another and there is a mutuality of risk factors,  please expand "Introduction" to
explain this common pathophysiology.
2) in Discussion section, please start with explaining results of a previous MR in details, to tie
these results down to the findings of present study.
3) from statistics standpoint, this MS is executed correctly, but the strength of the findings is
relatively weak (one of three models showed significance). Authors should discuss why they are
sure that found true causal connections; why this model correct but not other.
4) Please compare findings with PMID: 39205942 and PMID: 38847662  and explain what is
different and what is new.
REQUESTED REVISIONS:
please see comments above, especially concerning the novelty (point 4).
ADDITIONAL REQUESTS/SUGGESTIONS:
this is good quality MS, but may be these findings are already reported (please see novelty
concern)
assistant