Title: The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks
of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA
pathways
Version: 4 Date: 09 May 2022
Reviewer:  Alex Boye
Reviewer's report:
Dear Editor,
Authors have improved the manuscript but the following minor issues are outstanding:
1. Fig. 1E, check spelling of log rank
2. Fig. 2 – Is STAG3-OE the same as OE? Check to correct in all affected subfigures.
3. Chromosome is chromosome and meiosis is meiosis. Chromosome is the genetic material
in the nucleus which undergoes changes to reflect each of the stages of meiosis, which is a
type of cell division occurring in germ cells of sexually reproducing organisms. So the term
chromosomal meiosis needs to be clarified and contextualized.
4. Language needs to be improved further.
Title: The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks
of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA
pathways
Version: 4 Date: 09 May 2022
Reviewer:  Alex Boye
Reviewer's report:
Dear Editor,
Authors have improved the manuscript but the following minor issues are outstanding:
1. Fig. 1E, check spelling of log rank
2. Fig. 2 – Is STAG3-OE the same as OE? Check to correct in all affected subfigures.
3. Chromosome is chromosome and meiosis is meiosis. Chromosome is the genetic material
in the nucleus which undergoes changes to reflect each of the stages of meiosis, which is a
type of cell division occurring in germ cells of sexually reproducing organisms. So the term
chromosomal meiosis needs to be clarified and contextualized.
4. Language needs to be improved further.
Please review this paper.
user
Title: The upregulation of stromal antigen 3 expression suppresses the phenotypic hallmarks
of hepatocellular carcinoma through the Smad3-CDK4/CDK6-cyclin D1 and CXCR4/RhoA
pathways
Version: 4 Date: 09 May 2022
Reviewer:  Alex Boye
Reviewer's report:
Dear Editor,
Authors have improved the manuscript but the following minor issues are outstanding:
1. Fig. 1E, check spelling of log rank
2. Fig. 2 – Is STAG3-OE the same as OE? Check to correct in all affected subfigures.
3. Chromosome is chromosome and meiosis is meiosis. Chromosome is the genetic material
in the nucleus which undergoes changes to reflect each of the stages of meiosis, which is a
type of cell division occurring in germ cells of sexually reproducing organisms. So the term
chromosomal meiosis needs to be clarified and contextualized.
4. Language needs to be improved further.
assistant