Title: Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with
prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis
Version: 0 Date: 11 Apr 2025
Reviewer:  Ali Ogul
Reviewer's report:
Evaluation
This study titled “Relationship between neutrophil/lymphocyte and platelet/lymphocyte ratios
and prognosis in patients with gastric cancer who received neoadjuvant chemotherapy: a meta-
analysis” is a meta-analysis evaluating the role of systemic inflammation markers in prognosis.
The fact that MOOSE and PRISMA criteria were followed and the data were understandable
constitutes the strengths of the study. Exclusion and inclusion criteria were clearly stated in
the study. It was seen that 16 studies were included with a comprehensive literature review. In
addition, the fact that tests were conducted in terms of publication bias and sensitivity tests were
performed are other strengths of the study.
On the other hand, the study has a limitation due to its retrospective nature. Another limitation
is that DFS and RFS data are missing in most of the publications included in the study.
In addition, the fact that NAC regimens are applied differently in different countries makes the
study heterogeneous.
Another shortcoming of the study is that the included studies have different cut-off values.
For these reasons, I believe that the study will make a scientific contribution to the literature.
However, the above-mentioned limitations should be discussed in more detail in the study. As
a result, it is recommended that it be accepted with major revision.
Title: Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with
prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis
Version: 0 Date: 11 Apr 2025
Reviewer:  Ali Ogul
Reviewer's report:
Evaluation
This study titled “Relationship between neutrophil/lymphocyte and platelet/lymphocyte ratios
and prognosis in patients with gastric cancer who received neoadjuvant chemotherapy: a meta-
analysis” is a meta-analysis evaluating the role of systemic inflammation markers in prognosis.
The fact that MOOSE and PRISMA criteria were followed and the data were understandable
constitutes the strengths of the study. Exclusion and inclusion criteria were clearly stated in
the study. It was seen that 16 studies were included with a comprehensive literature review. In
addition, the fact that tests were conducted in terms of publication bias and sensitivity tests were
performed are other strengths of the study.
On the other hand, the study has a limitation due to its retrospective nature. Another limitation
is that DFS and RFS data are missing in most of the publications included in the study.
In addition, the fact that NAC regimens are applied differently in different countries makes the
study heterogeneous.
Another shortcoming of the study is that the included studies have different cut-off values.
For these reasons, I believe that the study will make a scientific contribution to the literature.
However, the above-mentioned limitations should be discussed in more detail in the study. As
a result, it is recommended that it be accepted with major revision.
Please review this paper.
user
Title: Correlation between neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio with
prognosis in gastric cancer patients undergoing neoadjuvant chemotherapy: a meta-analysis
Version: 0 Date: 11 Apr 2025
Reviewer:  Ali Ogul
Reviewer's report:
Evaluation
This study titled “Relationship between neutrophil/lymphocyte and platelet/lymphocyte ratios
and prognosis in patients with gastric cancer who received neoadjuvant chemotherapy: a meta-
analysis” is a meta-analysis evaluating the role of systemic inflammation markers in prognosis.
The fact that MOOSE and PRISMA criteria were followed and the data were understandable
constitutes the strengths of the study. Exclusion and inclusion criteria were clearly stated in
the study. It was seen that 16 studies were included with a comprehensive literature review. In
addition, the fact that tests were conducted in terms of publication bias and sensitivity tests were
performed are other strengths of the study.
On the other hand, the study has a limitation due to its retrospective nature. Another limitation
is that DFS and RFS data are missing in most of the publications included in the study.
In addition, the fact that NAC regimens are applied differently in different countries makes the
study heterogeneous.
Another shortcoming of the study is that the included studies have different cut-off values.
For these reasons, I believe that the study will make a scientific contribution to the literature.
However, the above-mentioned limitations should be discussed in more detail in the study. As
a result, it is recommended that it be accepted with major revision.
assistant