Reviewer's report
Title:Gastroesophageal reflux leads to esophageal cancer in a surgical model
with mice
Version: 2Date:12 December 2008
Reviewer: Glyn Jamieson
Reviewer's report:
I am afraid that in a scientific study to be told that" the numbers in each group
were not in any fixed pattern "is to state that the design of the study was
flawed.This lays the authors open to the criticism that numbers were used until
the investigators obtained the results that they wanted to see.
The numbers required should always be determined in advance (using statistical
power calculations) so that the minimum number of animals is used to answer
the hypothesis posed.This is the only ethical way we can justify using animals for
scientific research.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interests
Reviewer's report
Title:Gastroesophageal reflux leads to esophageal cancer in a surgical model
with mice
Version: 2Date:12 December 2008
Reviewer: Glyn Jamieson
Reviewer's report:
I am afraid that in a scientific study to be told that" the numbers in each group
were not in any fixed pattern "is to state that the design of the study was
flawed.This lays the authors open to the criticism that numbers were used until
the investigators obtained the results that they wanted to see.
The numbers required should always be determined in advance (using statistical
power calculations) so that the minimum number of animals is used to answer
the hypothesis posed.This is the only ethical way we can justify using animals for
scientific research.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interests
Please review this paper.
user
Reviewer's report
Title:Gastroesophageal reflux leads to esophageal cancer in a surgical model
with mice
Version: 2Date:12 December 2008
Reviewer: Glyn Jamieson
Reviewer's report:
I am afraid that in a scientific study to be told that" the numbers in each group
were not in any fixed pattern "is to state that the design of the study was
flawed.This lays the authors open to the criticism that numbers were used until
the investigators obtained the results that they wanted to see.
The numbers required should always be determined in advance (using statistical
power calculations) so that the minimum number of animals is used to answer
the hypothesis posed.This is the only ethical way we can justify using animals for
scientific research.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interests
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