Title: The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in
chronic hepatitis B: A novel Diagnostic and prognostic indicator
Version: 5 Date: 14 May 2025
Reviewer:  Yoshihiko Yano
Reviewer's report:
The content is interesting, but due to the small number of cases, we believe that a more detailed
study is needed.
1. In chronic hepatitis, it may be necessary to divide the units according to the stage (clinical
phase) of the disease. Is everything a phase of active hepatitis? Are there any asymptomatic
carriers or inactive carrier status? At least for METTL3 and METTL14, it seems necessary to
divide the disease into stages.
2. The units should be listed in each table.
3. The units should also be included in the Table.
Title: The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in
chronic hepatitis B: A novel Diagnostic and prognostic indicator
Version: 5 Date: 14 May 2025
Reviewer:  Yoshihiko Yano
Reviewer's report:
The content is interesting, but due to the small number of cases, we believe that a more detailed
study is needed.
1. In chronic hepatitis, it may be necessary to divide the units according to the stage (clinical
phase) of the disease. Is everything a phase of active hepatitis? Are there any asymptomatic
carriers or inactive carrier status? At least for METTL3 and METTL14, it seems necessary to
divide the disease into stages.
2. The units should be listed in each table.
3. The units should also be included in the Table.
Please review this paper.
user
Title: The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in
chronic hepatitis B: A novel Diagnostic and prognostic indicator
Version: 5 Date: 14 May 2025
Reviewer:  Yoshihiko Yano
Reviewer's report:
The content is interesting, but due to the small number of cases, we believe that a more detailed
study is needed.
1. In chronic hepatitis, it may be necessary to divide the units according to the stage (clinical
phase) of the disease. Is everything a phase of active hepatitis? Are there any asymptomatic
carriers or inactive carrier status? At least for METTL3 and METTL14, it seems necessary to
divide the disease into stages.
2. The units should be listed in each table.
3. The units should also be included in the Table.
assistant