Title: Identification of Inadequate Responders to Advanced Therapy Among Commercially-
Insured Adult Patients with Crohn’s Disease and Ulcerative Colitis in the United States
Version: 1 Date: 16 May 2022
Reviewer's report:
In this manuscript, the authors investigated their modified claims-based algorithm in the IBD
patients to assess inadequate response to the advanced therapy within 1 year and reported more
than 60% of patients had an inadequate response with low adherence as the most common reason,
which was compatible with the previous investigation in other chronic inflammatory condition
such as RA. They also identified several factors to be associated with the inadequate response by
a multivariable logistic regression model. However, some factors such as baseline use of TNFi
(vs non-TNFi) in UC and gender, historical use of TNFi, health plan, and region in CD cannot
be reasonably explained only by biology. The authors should carefully discuss them.
Title: Identification of Inadequate Responders to Advanced Therapy Among Commercially-
Insured Adult Patients with Crohn’s Disease and Ulcerative Colitis in the United States
Version: 1 Date: 16 May 2022
Reviewer's report:
In this manuscript, the authors investigated their modified claims-based algorithm in the IBD
patients to assess inadequate response to the advanced therapy within 1 year and reported more
than 60% of patients had an inadequate response with low adherence as the most common reason,
which was compatible with the previous investigation in other chronic inflammatory condition
such as RA. They also identified several factors to be associated with the inadequate response by
a multivariable logistic regression model. However, some factors such as baseline use of TNFi
(vs non-TNFi) in UC and gender, historical use of TNFi, health plan, and region in CD cannot
be reasonably explained only by biology. The authors should carefully discuss them.
Please review this paper.
user
Title: Identification of Inadequate Responders to Advanced Therapy Among Commercially-
Insured Adult Patients with Crohn’s Disease and Ulcerative Colitis in the United States
Version: 1 Date: 16 May 2022
Reviewer's report:
In this manuscript, the authors investigated their modified claims-based algorithm in the IBD
patients to assess inadequate response to the advanced therapy within 1 year and reported more
than 60% of patients had an inadequate response with low adherence as the most common reason,
which was compatible with the previous investigation in other chronic inflammatory condition
such as RA. They also identified several factors to be associated with the inadequate response by
a multivariable logistic regression model. However, some factors such as baseline use of TNFi
(vs non-TNFi) in UC and gender, historical use of TNFi, health plan, and region in CD cannot
be reasonably explained only by biology. The authors should carefully discuss them.
assistant