Title: An inflammation-based model for identifying severe acute pancreatitis: A single-center
retrospective study
Version: 3 Date: 18 Oct 2023
Reviewer's report:
1) NLR is used to determine systemic inflammation, and the laboratory test for NLR is globally
available and favorable. Besides viral infections; infection, renal failure, diabetes mellitus,
valvular heart diseases, acute coronary syndromes, thyroid functional abnormalities, metabolic
syndrome, essential hypertension, and many inflammatory diseases may affect NLR.Thus
exclusion criteria should be written in a more detailed manner and related references that explain
the matter written above should be mentioned in the manuscript (Sample Reference: Tano#lu
A, Düzenli T. Neutrophil-to-lymphocyte ratio alone may not be a true indicator of the severity
of acute pancreatitis. Turk J Gastroenterol. 2019;30(10):937 )
2) C-reactive protein-to-albumin ratio  (CAR) is a simple, rapid and easily calculated parameter
based on systemic inflammation. Relationship between NLR, CAR and other scores (for
example: Balthazar , Ranson etc) in predicting severity of acute pancreatitis is another
noteworthy issue. Thus this issue should be discussed in a detailed manner in the discussion
part and related references should be mentioned in the manuscript (Sample reference: Kiyak M,
Tanoglu A. Comparison of the Efficacy of Balthazar Score and C-Reactive Protein-Albumin
Ratio for Determination of Acute Pancreatitis Severity. Curr Health Sci J. 2022;48(1):81-87. )
Title: An inflammation-based model for identifying severe acute pancreatitis: A single-center
retrospective study
Version: 3 Date: 18 Oct 2023
Reviewer's report:
1) NLR is used to determine systemic inflammation, and the laboratory test for NLR is globally
available and favorable. Besides viral infections; infection, renal failure, diabetes mellitus,
valvular heart diseases, acute coronary syndromes, thyroid functional abnormalities, metabolic
syndrome, essential hypertension, and many inflammatory diseases may affect NLR.Thus
exclusion criteria should be written in a more detailed manner and related references that explain
the matter written above should be mentioned in the manuscript (Sample Reference: Tano#lu
A, Düzenli T. Neutrophil-to-lymphocyte ratio alone may not be a true indicator of the severity
of acute pancreatitis. Turk J Gastroenterol. 2019;30(10):937 )
2) C-reactive protein-to-albumin ratio  (CAR) is a simple, rapid and easily calculated parameter
based on systemic inflammation. Relationship between NLR, CAR and other scores (for
example: Balthazar , Ranson etc) in predicting severity of acute pancreatitis is another
noteworthy issue. Thus this issue should be discussed in a detailed manner in the discussion
part and related references should be mentioned in the manuscript (Sample reference: Kiyak M,
Tanoglu A. Comparison of the Efficacy of Balthazar Score and C-Reactive Protein-Albumin
Ratio for Determination of Acute Pancreatitis Severity. Curr Health Sci J. 2022;48(1):81-87. )
Please review this paper.
user
Title: An inflammation-based model for identifying severe acute pancreatitis: A single-center
retrospective study
Version: 3 Date: 18 Oct 2023
Reviewer's report:
1) NLR is used to determine systemic inflammation, and the laboratory test for NLR is globally
available and favorable. Besides viral infections; infection, renal failure, diabetes mellitus,
valvular heart diseases, acute coronary syndromes, thyroid functional abnormalities, metabolic
syndrome, essential hypertension, and many inflammatory diseases may affect NLR.Thus
exclusion criteria should be written in a more detailed manner and related references that explain
the matter written above should be mentioned in the manuscript (Sample Reference: Tano#lu
A, Düzenli T. Neutrophil-to-lymphocyte ratio alone may not be a true indicator of the severity
of acute pancreatitis. Turk J Gastroenterol. 2019;30(10):937 )
2) C-reactive protein-to-albumin ratio  (CAR) is a simple, rapid and easily calculated parameter
based on systemic inflammation. Relationship between NLR, CAR and other scores (for
example: Balthazar , Ranson etc) in predicting severity of acute pancreatitis is another
noteworthy issue. Thus this issue should be discussed in a detailed manner in the discussion
part and related references should be mentioned in the manuscript (Sample reference: Kiyak M,
Tanoglu A. Comparison of the Efficacy of Balthazar Score and C-Reactive Protein-Albumin
Ratio for Determination of Acute Pancreatitis Severity. Curr Health Sci J. 2022;48(1):81-87. )
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