Reviewer's report
Title:Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
Version: 1Date:15 December 2009
Reviewer: Jude Oben
Reviewer's report:
Given the importance of obesity induced liver disease as a major public health
threat in affluent nations, understanding the immunobiology of NAFLD/NASH is
clearly of importance as a prerequisite to devising preventative or curative
strategies. This mechanistic study by Rivera et al, is a welcomed addition in this
quest. The study concept is interesting, and the study designed and findings
interesting. That TLR 2 may confer some protection against NAFLD is novel and
should be on interest to your readers.
My comments are minor: the introduction has the potential to confuse:
the first paragraph refers to this type of liver disease being cryptogenic. Given
that many patients with NAFLD were previously classified as cryptogenic, the
sense of this pg should be altered to better reflect the fact that it is the
mechanism of NAFLD that is not fully elucidated, I would simply avoid
cryptogenic.
In the results section, Figure 1 is a little odd. There are no error bars for the
steatosis and necrosis. Was this an oversight or was the variability near minimal?
If these minor alterations could be made, I would be happier to recommend its
acceptance for publication
Reviewer's report
Title:Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
Version: 1Date:15 December 2009
Reviewer: Jude Oben
Reviewer's report:
Given the importance of obesity induced liver disease as a major public health
threat in affluent nations, understanding the immunobiology of NAFLD/NASH is
clearly of importance as a prerequisite to devising preventative or curative
strategies. This mechanistic study by Rivera et al, is a welcomed addition in this
quest. The study concept is interesting, and the study designed and findings
interesting. That TLR 2 may confer some protection against NAFLD is novel and
should be on interest to your readers.
My comments are minor: the introduction has the potential to confuse:
the first paragraph refers to this type of liver disease being cryptogenic. Given
that many patients with NAFLD were previously classified as cryptogenic, the
sense of this pg should be altered to better reflect the fact that it is the
mechanism of NAFLD that is not fully elucidated, I would simply avoid
cryptogenic.
In the results section, Figure 1 is a little odd. There are no error bars for the
steatosis and necrosis. Was this an oversight or was the variability near minimal?
If these minor alterations could be made, I would be happier to recommend its
acceptance for publication
Please review this paper.
user
Reviewer's report
Title:Toll-like receptor-2 deficiency enhances non-alcoholic steatohepatitis
Version: 1Date:15 December 2009
Reviewer: Jude Oben
Reviewer's report:
Given the importance of obesity induced liver disease as a major public health
threat in affluent nations, understanding the immunobiology of NAFLD/NASH is
clearly of importance as a prerequisite to devising preventative or curative
strategies. This mechanistic study by Rivera et al, is a welcomed addition in this
quest. The study concept is interesting, and the study designed and findings
interesting. That TLR 2 may confer some protection against NAFLD is novel and
should be on interest to your readers.
My comments are minor: the introduction has the potential to confuse:
the first paragraph refers to this type of liver disease being cryptogenic. Given
that many patients with NAFLD were previously classified as cryptogenic, the
sense of this pg should be altered to better reflect the fact that it is the
mechanism of NAFLD that is not fully elucidated, I would simply avoid
cryptogenic.
In the results section, Figure 1 is a little odd. There are no error bars for the
steatosis and necrosis. Was this an oversight or was the variability near minimal?
If these minor alterations could be made, I would be happier to recommend its
acceptance for publication
assistant