Title: Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing
endoscopic inflammatory bowel disease severity
Version: 3 Date: 30 Sep 2023
Reviewer's report:
The authors focused on the PLT/ALB ratio to search for new biomarkers in inflammatory
bowel disease and confirmed that the PLT/ALB ratio and PCT biomarker are useful among
inflammatory biomarkers for assessing endoscopic IBD activity in patients with UC and CD.
Although there are currently several studies on biomarkers to evaluate disease activity in
inflammatory bowel disease, the authors' report is very interesting because it is a simple method
that can be confirmed using ordinary blood test data.
Although the number of cases is large and the study is well done, a few points need to be
confirmed before publication.
1) How long before and after blood tests and endoscopy were clinical symptoms identified in
ulcerative colitis and Crohn's disease?
2) In the Conclusion section, the authors state that the PLT/ALB ratio is the most useful test
for assessing endoscopic activity compared to other tests, especially in CD, which seems to be
comparable to others. The authors should elaborate on the reasons for this conclusion.
Title: Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing
endoscopic inflammatory bowel disease severity
Version: 3 Date: 30 Sep 2023
Reviewer's report:
The authors focused on the PLT/ALB ratio to search for new biomarkers in inflammatory
bowel disease and confirmed that the PLT/ALB ratio and PCT biomarker are useful among
inflammatory biomarkers for assessing endoscopic IBD activity in patients with UC and CD.
Although there are currently several studies on biomarkers to evaluate disease activity in
inflammatory bowel disease, the authors' report is very interesting because it is a simple method
that can be confirmed using ordinary blood test data.
Although the number of cases is large and the study is well done, a few points need to be
confirmed before publication.
1) How long before and after blood tests and endoscopy were clinical symptoms identified in
ulcerative colitis and Crohn's disease?
2) In the Conclusion section, the authors state that the PLT/ALB ratio is the most useful test
for assessing endoscopic activity compared to other tests, especially in CD, which seems to be
comparable to others. The authors should elaborate on the reasons for this conclusion.
Please review this paper.
user
Title: Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing
endoscopic inflammatory bowel disease severity
Version: 3 Date: 30 Sep 2023
Reviewer's report:
The authors focused on the PLT/ALB ratio to search for new biomarkers in inflammatory
bowel disease and confirmed that the PLT/ALB ratio and PCT biomarker are useful among
inflammatory biomarkers for assessing endoscopic IBD activity in patients with UC and CD.
Although there are currently several studies on biomarkers to evaluate disease activity in
inflammatory bowel disease, the authors' report is very interesting because it is a simple method
that can be confirmed using ordinary blood test data.
Although the number of cases is large and the study is well done, a few points need to be
confirmed before publication.
1) How long before and after blood tests and endoscopy were clinical symptoms identified in
ulcerative colitis and Crohn's disease?
2) In the Conclusion section, the authors state that the PLT/ALB ratio is the most useful test
for assessing endoscopic activity compared to other tests, especially in CD, which seems to be
comparable to others. The authors should elaborate on the reasons for this conclusion.
assistant