Title: Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon
cancer
Version: 1 Date: 20 Jun 2023
Reviewer's report:
Thank you for allowing me to review the manuscript titled "Comprehensive analysis of CXCL14
uncovers its role during liver metastasis in colon cancer". In this study, Zhou and their colleagues
identified CXCL14 as an underlying therapeutic target for colon cancer. The study provides
valuable insights, yet there are a few areas that need to be addressed for a more robust
interpretation of the results.
Firstly, the results section would benefit from a more comprehensive statistical analysis. Specific
p-values and confidence intervals would bolster the significance of the findings. In the discussion
section, it is recommended to compare and contrast the results with previous related studies.
This would help to place the findings in the broader context of the field.
Secondly, according to the analysis results, the author seems to have many candidate genes, why
only choose CXCL14?
Thirdly, please provide a specific explanation of Figure 3. The existing description does not
allow me to understand it well.
Fourthly, are Figures 5a and 5b-g both gsea analyses? The display forms of the two seem
different
Fifthly, the author should specifically discuss the potential and potential application prospects
of CXCL14 as a clinical target for colon cancer in the discussion section,
Sixthly, I think the author needs to provide a more detailed methodology section to improve the
repeatability of the research.
Seventhly, The author should improve the general information of the included patients.
Title: Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon
cancer
Version: 1 Date: 20 Jun 2023
Reviewer's report:
Thank you for allowing me to review the manuscript titled "Comprehensive analysis of CXCL14
uncovers its role during liver metastasis in colon cancer". In this study, Zhou and their colleagues
identified CXCL14 as an underlying therapeutic target for colon cancer. The study provides
valuable insights, yet there are a few areas that need to be addressed for a more robust
interpretation of the results.
Firstly, the results section would benefit from a more comprehensive statistical analysis. Specific
p-values and confidence intervals would bolster the significance of the findings. In the discussion
section, it is recommended to compare and contrast the results with previous related studies.
This would help to place the findings in the broader context of the field.
Secondly, according to the analysis results, the author seems to have many candidate genes, why
only choose CXCL14?
Thirdly, please provide a specific explanation of Figure 3. The existing description does not
allow me to understand it well.
Fourthly, are Figures 5a and 5b-g both gsea analyses? The display forms of the two seem
different
Fifthly, the author should specifically discuss the potential and potential application prospects
of CXCL14 as a clinical target for colon cancer in the discussion section,
Sixthly, I think the author needs to provide a more detailed methodology section to improve the
repeatability of the research.
Seventhly, The author should improve the general information of the included patients.
Please review this paper.
user
Title: Comprehensive analysis of CXCL14 uncovers its role during liver metastasis in colon
cancer
Version: 1 Date: 20 Jun 2023
Reviewer's report:
Thank you for allowing me to review the manuscript titled "Comprehensive analysis of CXCL14
uncovers its role during liver metastasis in colon cancer". In this study, Zhou and their colleagues
identified CXCL14 as an underlying therapeutic target for colon cancer. The study provides
valuable insights, yet there are a few areas that need to be addressed for a more robust
interpretation of the results.
Firstly, the results section would benefit from a more comprehensive statistical analysis. Specific
p-values and confidence intervals would bolster the significance of the findings. In the discussion
section, it is recommended to compare and contrast the results with previous related studies.
This would help to place the findings in the broader context of the field.
Secondly, according to the analysis results, the author seems to have many candidate genes, why
only choose CXCL14?
Thirdly, please provide a specific explanation of Figure 3. The existing description does not
allow me to understand it well.
Fourthly, are Figures 5a and 5b-g both gsea analyses? The display forms of the two seem
different
Fifthly, the author should specifically discuss the potential and potential application prospects
of CXCL14 as a clinical target for colon cancer in the discussion section,
Sixthly, I think the author needs to provide a more detailed methodology section to improve the
repeatability of the research.
Seventhly, The author should improve the general information of the included patients.
assistant