Title: Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal
hemodynamics and liver function
Version: 3 Date: 22 Jun 2022
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS:
This study is important in improving of using sclerotherapy in relation to health parameters and
therapy.
Author have done Application and technique of EIS, Xe-CT theory and imaging,  study design,
statistical analysis figure performance, endoscopy done during several times week, months
ADDITIONAL REQUESTS/SUGGESTIONS:
This study is important in improving of using sclerotherapy in relation to health parameters
and therapy. Author have done Application and technique of EIS, Xe-CT theory and imaging,
study design, statistical analysis figure performance, endoscopy done during several times week,
months.*The experimental design is valid. However some comment require answer:
*In methods section: Kits, method or references should be provided for biochemical laboratory
tests for albumin, Bilirubin, PT% and ammonia.
*Page 9, Application and technique of EIS Is valid including,  Child-Pugh classification of grade
A or B. however author should appreciate using the injection sclerotherapy procedure for the
secondary prophylatics of varical bleeding  not just writing the word “prevention “ which is a
vague vocab
*Table 3 Albumin IG, indicated that 6M after EIS p =0.2431 while  12M after EIS p=0.0009 in
comparison with before EIS, however the median nearly the same. Please revise this data.
Also, Child-Pugh score, during 6 M and 12 M the same median but significant in 12 M, not in
6 M, please revise it."
Title: Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal
hemodynamics and liver function
Version: 3 Date: 22 Jun 2022
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS:
This study is important in improving of using sclerotherapy in relation to health parameters and
therapy.
Author have done Application and technique of EIS, Xe-CT theory and imaging,  study design,
statistical analysis figure performance, endoscopy done during several times week, months
ADDITIONAL REQUESTS/SUGGESTIONS:
This study is important in improving of using sclerotherapy in relation to health parameters
and therapy. Author have done Application and technique of EIS, Xe-CT theory and imaging,
study design, statistical analysis figure performance, endoscopy done during several times week,
months.*The experimental design is valid. However some comment require answer:
*In methods section: Kits, method or references should be provided for biochemical laboratory
tests for albumin, Bilirubin, PT% and ammonia.
*Page 9, Application and technique of EIS Is valid including,  Child-Pugh classification of grade
A or B. however author should appreciate using the injection sclerotherapy procedure for the
secondary prophylatics of varical bleeding  not just writing the word “prevention “ which is a
vague vocab
*Table 3 Albumin IG, indicated that 6M after EIS p =0.2431 while  12M after EIS p=0.0009 in
comparison with before EIS, however the median nearly the same. Please revise this data.
Also, Child-Pugh score, during 6 M and 12 M the same median but significant in 12 M, not in
6 M, please revise it."
Please review this paper.
user
Title: Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal
hemodynamics and liver function
Version: 3 Date: 22 Jun 2022
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS:
This study is important in improving of using sclerotherapy in relation to health parameters and
therapy.
Author have done Application and technique of EIS, Xe-CT theory and imaging,  study design,
statistical analysis figure performance, endoscopy done during several times week, months
ADDITIONAL REQUESTS/SUGGESTIONS:
This study is important in improving of using sclerotherapy in relation to health parameters
and therapy. Author have done Application and technique of EIS, Xe-CT theory and imaging,
study design, statistical analysis figure performance, endoscopy done during several times week,
months.*The experimental design is valid. However some comment require answer:
*In methods section: Kits, method or references should be provided for biochemical laboratory
tests for albumin, Bilirubin, PT% and ammonia.
*Page 9, Application and technique of EIS Is valid including,  Child-Pugh classification of grade
A or B. however author should appreciate using the injection sclerotherapy procedure for the
secondary prophylatics of varical bleeding  not just writing the word “prevention “ which is a
vague vocab
*Table 3 Albumin IG, indicated that 6M after EIS p =0.2431 while  12M after EIS p=0.0009 in
comparison with before EIS, however the median nearly the same. Please revise this data.
Also, Child-Pugh score, during 6 M and 12 M the same median but significant in 12 M, not in
6 M, please revise it."
assistant