Title: Advances in the management of gallbladder polyps: Establishment of predictive models
and the rise of gallbladder-preserving polypectomy procedures
Version: 0 Date: 18 Jul 2023
Reviewer's report:
Authors have summarized the current literature and clinical practices involving the management
of gallbladder polyps and have highlighted the pitfalls in this strategy.
The manuscript is well written.
English is appropriate.
Review of literature is adequate.
Gallbladder preserving surgery for GB polyps are well explained, although I do recommend
adding pictorial diagrams to make it easier for audience to comprehend it. Also, the risk with
these interventions and the financial burden that comes with multi-step interventions needs to
be taken into consideration.
Tests to assess GB function (before or after intervention) have inherent pitfalls and sometimes
do not correlate clinically. Hence, there is need to also improvise or develop new tests to help
assess GB function more precisely which can also correlate with clinical symptoms.
Although cholecystectomy is linked with some future medical problems, none has yet
established a causal relationship.  Also the complications associated with cholecystectomy
have continued to down-trend with increasing expertise. As a result, cholecystectomy is still
considered the best practice in such scenarios. There is need of prospective long term studies to
truly assess the risk of cholecystectomy. Recommend authors to consider expanding on these
aspects in their discussion section.
Discussion on predictive models is suggestive of widespread heterogeneity across the different
models and this emphasizes on the need to design the new models which can overcome existing
pitfalls.
Overall I recommend publishing this article, once authors edit the manuscript as above. This
will incite the readers to understand the current deficiencies and hopefully will encourage new
research in this field.
Title: Advances in the management of gallbladder polyps: Establishment of predictive models
and the rise of gallbladder-preserving polypectomy procedures
Version: 0 Date: 18 Jul 2023
Reviewer's report:
Authors have summarized the current literature and clinical practices involving the management
of gallbladder polyps and have highlighted the pitfalls in this strategy.
The manuscript is well written.
English is appropriate.
Review of literature is adequate.
Gallbladder preserving surgery for GB polyps are well explained, although I do recommend
adding pictorial diagrams to make it easier for audience to comprehend it. Also, the risk with
these interventions and the financial burden that comes with multi-step interventions needs to
be taken into consideration.
Tests to assess GB function (before or after intervention) have inherent pitfalls and sometimes
do not correlate clinically. Hence, there is need to also improvise or develop new tests to help
assess GB function more precisely which can also correlate with clinical symptoms.
Although cholecystectomy is linked with some future medical problems, none has yet
established a causal relationship.  Also the complications associated with cholecystectomy
have continued to down-trend with increasing expertise. As a result, cholecystectomy is still
considered the best practice in such scenarios. There is need of prospective long term studies to
truly assess the risk of cholecystectomy. Recommend authors to consider expanding on these
aspects in their discussion section.
Discussion on predictive models is suggestive of widespread heterogeneity across the different
models and this emphasizes on the need to design the new models which can overcome existing
pitfalls.
Overall I recommend publishing this article, once authors edit the manuscript as above. This
will incite the readers to understand the current deficiencies and hopefully will encourage new
research in this field.
Please review this paper.
user
Title: Advances in the management of gallbladder polyps: Establishment of predictive models
and the rise of gallbladder-preserving polypectomy procedures
Version: 0 Date: 18 Jul 2023
Reviewer's report:
Authors have summarized the current literature and clinical practices involving the management
of gallbladder polyps and have highlighted the pitfalls in this strategy.
The manuscript is well written.
English is appropriate.
Review of literature is adequate.
Gallbladder preserving surgery for GB polyps are well explained, although I do recommend
adding pictorial diagrams to make it easier for audience to comprehend it. Also, the risk with
these interventions and the financial burden that comes with multi-step interventions needs to
be taken into consideration.
Tests to assess GB function (before or after intervention) have inherent pitfalls and sometimes
do not correlate clinically. Hence, there is need to also improvise or develop new tests to help
assess GB function more precisely which can also correlate with clinical symptoms.
Although cholecystectomy is linked with some future medical problems, none has yet
established a causal relationship.  Also the complications associated with cholecystectomy
have continued to down-trend with increasing expertise. As a result, cholecystectomy is still
considered the best practice in such scenarios. There is need of prospective long term studies to
truly assess the risk of cholecystectomy. Recommend authors to consider expanding on these
aspects in their discussion section.
Discussion on predictive models is suggestive of widespread heterogeneity across the different
models and this emphasizes on the need to design the new models which can overcome existing
pitfalls.
Overall I recommend publishing this article, once authors edit the manuscript as above. This
will incite the readers to understand the current deficiencies and hopefully will encourage new
research in this field.
assistant