Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 10 Jul 2024
Reviewer's report:
Major comments
1. [Introduction] I suggest an additional explanation of previous epidemiological studies on
associations between metabolites and cancer or gastric diseases. I noticed that the author
described the previous studies in the Discussion section, and I suggest that the author move the
part of the contents to the Introduction section.
2. [Introduction] It would be better if the author stated the specific SNPs or genes linked with
serum metabolites identified by previously published studies.
3. [Results: Replication and Meta-analysis] According to TableA5, only three (not seven)
metabolites seem to show concordant direction in discovery and replication.
4. [Discussion] I suggest describing the biological functions and clinical implications of the
three metabolites identified.
Minor comments
1. [Abstract] In the conclusion section, I suggest to mention specific metabolites (e.g., 3-
methyl-2-oxovalerate, piperine, phenylalanylphenylalanine).
2. [Introduction] There are some unnecessary spaces between paragraphs.
3. [Materials and Methods: GWAS Data for Human Blood Metabolites] The Shin’s study needs
citation.
4. [Results: Strength of the IVs] The way to mention the supplementary table differs between
the manuscript and the additional table file (e.g., Manuscript: Table A2, Supplementary table
file: Table S2).
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 10 Jul 2024
Reviewer's report:
Major comments
1. [Introduction] I suggest an additional explanation of previous epidemiological studies on
associations between metabolites and cancer or gastric diseases. I noticed that the author
described the previous studies in the Discussion section, and I suggest that the author move the
part of the contents to the Introduction section.
2. [Introduction] It would be better if the author stated the specific SNPs or genes linked with
serum metabolites identified by previously published studies.
3. [Results: Replication and Meta-analysis] According to TableA5, only three (not seven)
metabolites seem to show concordant direction in discovery and replication.
4. [Discussion] I suggest describing the biological functions and clinical implications of the
three metabolites identified.
Minor comments
1. [Abstract] In the conclusion section, I suggest to mention specific metabolites (e.g., 3-
methyl-2-oxovalerate, piperine, phenylalanylphenylalanine).
2. [Introduction] There are some unnecessary spaces between paragraphs.
3. [Materials and Methods: GWAS Data for Human Blood Metabolites] The Shin’s study needs
citation.
4. [Results: Strength of the IVs] The way to mention the supplementary table differs between
the manuscript and the additional table file (e.g., Manuscript: Table A2, Supplementary table
file: Table S2).
Please review this paper.
user
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 10 Jul 2024
Reviewer's report:
Major comments
1. [Introduction] I suggest an additional explanation of previous epidemiological studies on
associations between metabolites and cancer or gastric diseases. I noticed that the author
described the previous studies in the Discussion section, and I suggest that the author move the
part of the contents to the Introduction section.
2. [Introduction] It would be better if the author stated the specific SNPs or genes linked with
serum metabolites identified by previously published studies.
3. [Results: Replication and Meta-analysis] According to TableA5, only three (not seven)
metabolites seem to show concordant direction in discovery and replication.
4. [Discussion] I suggest describing the biological functions and clinical implications of the
three metabolites identified.
Minor comments
1. [Abstract] In the conclusion section, I suggest to mention specific metabolites (e.g., 3-
methyl-2-oxovalerate, piperine, phenylalanylphenylalanine).
2. [Introduction] There are some unnecessary spaces between paragraphs.
3. [Materials and Methods: GWAS Data for Human Blood Metabolites] The Shin’s study needs
citation.
4. [Results: Strength of the IVs] The way to mention the supplementary table differs between
the manuscript and the additional table file (e.g., Manuscript: Table A2, Supplementary table
file: Table S2).
assistant