Reviewer's report
Title:Fibroblast growth factor 23 contributes to diminished bone mineral density
in childhood inflammatory bowel disease
Version: 1Date:15 March 2012
Reviewer: Federica Nuti
Reviewer's report:
Major Compulsory Revisions
In the DISCUSSION:
could you please explain more exstensively the importance of unraveling the
defects in bone metabolism in IBD patients, especially children,
and are you then able to hypothize a clinical implication deriving from your
findings?
Another important variable when assessing improvements in bone metabolism is
evaluation of physical activity, do you have the chance to evaluate this variable
when assessing the BMD improvements in your children?
In the discussion there is a sentence that, to me, appears not to clear as its
reference number 39 doesn't appear correlated to the sentence, could you
please check and explain?
Did you note any difference in the flare values of BMD, FGF 23 and the other
biochemical markers, in patients with a new diagnosis compared to patients with
a previous diagnosis (and so with a past history of therapy!)?
Minor essential revisions
In the PTH paragraph, in the first sentence "high" should be changed in "higher".
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Fibroblast growth factor 23 contributes to diminished bone mineral density
in childhood inflammatory bowel disease
Version: 1Date:15 March 2012
Reviewer: Federica Nuti
Reviewer's report:
Major Compulsory Revisions
In the DISCUSSION:
could you please explain more exstensively the importance of unraveling the
defects in bone metabolism in IBD patients, especially children,
and are you then able to hypothize a clinical implication deriving from your
findings?
Another important variable when assessing improvements in bone metabolism is
evaluation of physical activity, do you have the chance to evaluate this variable
when assessing the BMD improvements in your children?
In the discussion there is a sentence that, to me, appears not to clear as its
reference number 39 doesn't appear correlated to the sentence, could you
please check and explain?
Did you note any difference in the flare values of BMD, FGF 23 and the other
biochemical markers, in patients with a new diagnosis compared to patients with
a previous diagnosis (and so with a past history of therapy!)?
Minor essential revisions
In the PTH paragraph, in the first sentence "high" should be changed in "higher".
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Fibroblast growth factor 23 contributes to diminished bone mineral density
in childhood inflammatory bowel disease
Version: 1Date:15 March 2012
Reviewer: Federica Nuti
Reviewer's report:
Major Compulsory Revisions
In the DISCUSSION:
could you please explain more exstensively the importance of unraveling the
defects in bone metabolism in IBD patients, especially children,
and are you then able to hypothize a clinical implication deriving from your
findings?
Another important variable when assessing improvements in bone metabolism is
evaluation of physical activity, do you have the chance to evaluate this variable
when assessing the BMD improvements in your children?
In the discussion there is a sentence that, to me, appears not to clear as its
reference number 39 doesn't appear correlated to the sentence, could you
please check and explain?
Did you note any difference in the flare values of BMD, FGF 23 and the other
biochemical markers, in patients with a new diagnosis compared to patients with
a previous diagnosis (and so with a past history of therapy!)?
Minor essential revisions
In the PTH paragraph, in the first sentence "high" should be changed in "higher".
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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