Title: Frequency of Insulin Resistance among Non-Diabetic Patients with Non-Alcoholic Fatty
Liver Disease Using HOMA-IR: An Experience of a Tertiary Care Hospital in Karachi, Pakistan
Version: 3 Date: 23 Jan 2025
Reviewer:  Ronald Pratama Adiwinoto
Reviewer's report:
Dear Authors,
Firstly, I would like to commend you on an exemplary manuscript. Your study investigating
the "Frequency of Insulin Resistance among Non-Diabetic Patients with Non-Alcoholic Fatty
Liver Disease Using HOMA-IR" adds valuable insights to the field. Your methodology is robust,
and the results are presented with clarity and insight. The discussion contextualizes the findings
effectively within the existing literature. Here are a few suggestions before final submission:
1). Formatting and Editorial Adjustments: Please ensure the manuscript adheres to the BMC
Gastroenterology journal's guidelines regarding format, fonts, and reference style. This will
facilitate a seamless editorial review process.
2). Figures and Tables: Double-check that all figures and tables are clearly labeled and
referenced appropriately within the text.
3). Potential Explored Insights: While the study is comprehensive, consider briefly mentioning
the potential genetic or ethnic factors as future research directions, which could broaden the
study's impact.
A little suggestion for the ethical feasibility of the study, eventhough the authors stated that the
study was adhered to the Helsinki declaration, it would be more appropriate to add the statement
of adherence to the WHO-CIOMS  (The Council for International Organizations of Medical
Sciences) guideline for research involving human subjects. This is just a suggestion.
Your work is certainly a significant contribution to understanding NAFLD and insulin
resistance, and I highly recommend its acceptance after these minor adjustments.
Best regards,
Ronald Pratama Adiwinoto
(https://orcid.org/0000-0002-2112-610X)
Title: Frequency of Insulin Resistance among Non-Diabetic Patients with Non-Alcoholic Fatty
Liver Disease Using HOMA-IR: An Experience of a Tertiary Care Hospital in Karachi, Pakistan
Version: 3 Date: 23 Jan 2025
Reviewer:  Ronald Pratama Adiwinoto
Reviewer's report:
Dear Authors,
Firstly, I would like to commend you on an exemplary manuscript. Your study investigating
the "Frequency of Insulin Resistance among Non-Diabetic Patients with Non-Alcoholic Fatty
Liver Disease Using HOMA-IR" adds valuable insights to the field. Your methodology is robust,
and the results are presented with clarity and insight. The discussion contextualizes the findings
effectively within the existing literature. Here are a few suggestions before final submission:
1). Formatting and Editorial Adjustments: Please ensure the manuscript adheres to the BMC
Gastroenterology journal's guidelines regarding format, fonts, and reference style. This will
facilitate a seamless editorial review process.
2). Figures and Tables: Double-check that all figures and tables are clearly labeled and
referenced appropriately within the text.
3). Potential Explored Insights: While the study is comprehensive, consider briefly mentioning
the potential genetic or ethnic factors as future research directions, which could broaden the
study's impact.
A little suggestion for the ethical feasibility of the study, eventhough the authors stated that the
study was adhered to the Helsinki declaration, it would be more appropriate to add the statement
of adherence to the WHO-CIOMS  (The Council for International Organizations of Medical
Sciences) guideline for research involving human subjects. This is just a suggestion.
Your work is certainly a significant contribution to understanding NAFLD and insulin
resistance, and I highly recommend its acceptance after these minor adjustments.
Best regards,
Ronald Pratama Adiwinoto
(https://orcid.org/0000-0002-2112-610X)
Please review this paper.
user
Title: Frequency of Insulin Resistance among Non-Diabetic Patients with Non-Alcoholic Fatty
Liver Disease Using HOMA-IR: An Experience of a Tertiary Care Hospital in Karachi, Pakistan
Version: 3 Date: 23 Jan 2025
Reviewer:  Ronald Pratama Adiwinoto
Reviewer's report:
Dear Authors,
Firstly, I would like to commend you on an exemplary manuscript. Your study investigating
the "Frequency of Insulin Resistance among Non-Diabetic Patients with Non-Alcoholic Fatty
Liver Disease Using HOMA-IR" adds valuable insights to the field. Your methodology is robust,
and the results are presented with clarity and insight. The discussion contextualizes the findings
effectively within the existing literature. Here are a few suggestions before final submission:
1). Formatting and Editorial Adjustments: Please ensure the manuscript adheres to the BMC
Gastroenterology journal's guidelines regarding format, fonts, and reference style. This will
facilitate a seamless editorial review process.
2). Figures and Tables: Double-check that all figures and tables are clearly labeled and
referenced appropriately within the text.
3). Potential Explored Insights: While the study is comprehensive, consider briefly mentioning
the potential genetic or ethnic factors as future research directions, which could broaden the
study's impact.
A little suggestion for the ethical feasibility of the study, eventhough the authors stated that the
study was adhered to the Helsinki declaration, it would be more appropriate to add the statement
of adherence to the WHO-CIOMS  (The Council for International Organizations of Medical
Sciences) guideline for research involving human subjects. This is just a suggestion.
Your work is certainly a significant contribution to understanding NAFLD and insulin
resistance, and I highly recommend its acceptance after these minor adjustments.
Best regards,
Ronald Pratama Adiwinoto
(https://orcid.org/0000-0002-2112-610X)
assistant