Title: B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation
Version: 2 Date: 05 May 2024
Reviewer's report:
I read the full text carefully. The author found the important role of B3GNT7 in the pathogenesis
of ulcerative colitis through bioinformation technology, and it was verified in ulcerative colitis
patients and DSS induced colitis models. At the same time, KEGG enrichment analysis and PPI
analysis found some potential targets, and the process was very smooth. But the puzzle is that
since the authors have carried out animal experiments, why did they not verify these targets?
Therefore, I think this article does not meet the requirements for journal publication. The author
may also submit the application again by means of supplementary experiments.
Title: B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation
Version: 2 Date: 05 May 2024
Reviewer's report:
I read the full text carefully. The author found the important role of B3GNT7 in the pathogenesis
of ulcerative colitis through bioinformation technology, and it was verified in ulcerative colitis
patients and DSS induced colitis models. At the same time, KEGG enrichment analysis and PPI
analysis found some potential targets, and the process was very smooth. But the puzzle is that
since the authors have carried out animal experiments, why did they not verify these targets?
Therefore, I think this article does not meet the requirements for journal publication. The author
may also submit the application again by means of supplementary experiments.
Please review this paper.
user
Title: B3GNT7 regulates mucin O-glycosylation to alleviate colonic inflammation
Version: 2 Date: 05 May 2024
Reviewer's report:
I read the full text carefully. The author found the important role of B3GNT7 in the pathogenesis
of ulcerative colitis through bioinformation technology, and it was verified in ulcerative colitis
patients and DSS induced colitis models. At the same time, KEGG enrichment analysis and PPI
analysis found some potential targets, and the process was very smooth. But the puzzle is that
since the authors have carried out animal experiments, why did they not verify these targets?
Therefore, I think this article does not meet the requirements for journal publication. The author
may also submit the application again by means of supplementary experiments.
assistant