Reviewer's report
Title:Age-specific prevalence of serrated polyps and its subgroups by screening
colonoscopy
Version: 2Date:2 October 2013
Reviewer: Shuji Ogino
Reviewer's report:
Major compulsory revisions
This is an interesting study. Analysis methods and data are generally fine. I
request the authors to quote following references to further discuss important
points:
1. Rex D, et al. Am J Gastroenterol 2012 (expert recommendations on serrated
lesions. First, terminology – serrated polyps should not be used)
2. Yamauchi M, et al. Gut 2012 (This study showed a continuum of molecular
changes (CIMP, MSI, BRAF mutation) from rectum to ascending colon. This
study has big impact on gastroenterology, because of the prevalent dogma of
proximal vs. distal dichotomy, which is clearly oversimplification.)
3. Yamauchi M, et al. Gut 2012 (this is a review and presents discussion of the
colorectal continuum model)
4. Nishihara R, et al. N Engl J Med 2013 (recent study showed long-term effect of
colonoscopy in population-based cohort studies. This also showed that
CIMP-high cancer which arises from serrated lesions is more difficult to prevent,
than non-CIMP-high cancer.)
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'.
Reviewer's report
Title:Age-specific prevalence of serrated polyps and its subgroups by screening
colonoscopy
Version: 2Date:2 October 2013
Reviewer: Shuji Ogino
Reviewer's report:
Major compulsory revisions
This is an interesting study. Analysis methods and data are generally fine. I
request the authors to quote following references to further discuss important
points:
1. Rex D, et al. Am J Gastroenterol 2012 (expert recommendations on serrated
lesions. First, terminology – serrated polyps should not be used)
2. Yamauchi M, et al. Gut 2012 (This study showed a continuum of molecular
changes (CIMP, MSI, BRAF mutation) from rectum to ascending colon. This
study has big impact on gastroenterology, because of the prevalent dogma of
proximal vs. distal dichotomy, which is clearly oversimplification.)
3. Yamauchi M, et al. Gut 2012 (this is a review and presents discussion of the
colorectal continuum model)
4. Nishihara R, et al. N Engl J Med 2013 (recent study showed long-term effect of
colonoscopy in population-based cohort studies. This also showed that
CIMP-high cancer which arises from serrated lesions is more difficult to prevent,
than non-CIMP-high cancer.)
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'.
Please review this paper.
user
Reviewer's report
Title:Age-specific prevalence of serrated polyps and its subgroups by screening
colonoscopy
Version: 2Date:2 October 2013
Reviewer: Shuji Ogino
Reviewer's report:
Major compulsory revisions
This is an interesting study. Analysis methods and data are generally fine. I
request the authors to quote following references to further discuss important
points:
1. Rex D, et al. Am J Gastroenterol 2012 (expert recommendations on serrated
lesions. First, terminology – serrated polyps should not be used)
2. Yamauchi M, et al. Gut 2012 (This study showed a continuum of molecular
changes (CIMP, MSI, BRAF mutation) from rectum to ascending colon. This
study has big impact on gastroenterology, because of the prevalent dogma of
proximal vs. distal dichotomy, which is clearly oversimplification.)
3. Yamauchi M, et al. Gut 2012 (this is a review and presents discussion of the
colorectal continuum model)
4. Nishihara R, et al. N Engl J Med 2013 (recent study showed long-term effect of
colonoscopy in population-based cohort studies. This also showed that
CIMP-high cancer which arises from serrated lesions is more difficult to prevent,
than non-CIMP-high cancer.)
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'.
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