Title: Impact and usefulness of the transition to the new MAFLD classification for non-B, non-
C HCC: A retrospective cohort study
Version: 0 Date: 11 Apr 2023
Reviewer:  Ludovico Abenavoli
Reviewer's report:
The aim of the article is to evaluate the clinical characteristics of patients with MAFLD and
HCC)in comparison with those with NAFLD and considered the validity and challenges of the
new criteria. The article is interesting and updated. I found the following suggestions for the
Author:
- Introduction section: HCC is a typical example of a virus-related cancer, it is also well known
to be strongly related to life style. Chronic alcoholism is a classic risk factor. However, more
recently, obesity has been recognized to strongly affect HCC development in males, versus
various other tumors. There is also growing evidences suggesting that type 2 diabetes increases
the incidence of HCC. Due to the globally increasing proportion of the obese people, obesity-
related HCC will likely continue to increased (PMID: 32582865)
- Methods section: is important to underline in thi section the alcohol consumption definition
degree of the included patients.  Alcohol intake play a pitola role in the onset and development
of HCC
- Discussion section: i suggests to report the pivotal role played by metabolic features in
development of HCC in MAFLD patients
Title: Impact and usefulness of the transition to the new MAFLD classification for non-B, non-
C HCC: A retrospective cohort study
Version: 0 Date: 11 Apr 2023
Reviewer:  Ludovico Abenavoli
Reviewer's report:
The aim of the article is to evaluate the clinical characteristics of patients with MAFLD and
HCC)in comparison with those with NAFLD and considered the validity and challenges of the
new criteria. The article is interesting and updated. I found the following suggestions for the
Author:
- Introduction section: HCC is a typical example of a virus-related cancer, it is also well known
to be strongly related to life style. Chronic alcoholism is a classic risk factor. However, more
recently, obesity has been recognized to strongly affect HCC development in males, versus
various other tumors. There is also growing evidences suggesting that type 2 diabetes increases
the incidence of HCC. Due to the globally increasing proportion of the obese people, obesity-
related HCC will likely continue to increased (PMID: 32582865)
- Methods section: is important to underline in thi section the alcohol consumption definition
degree of the included patients.  Alcohol intake play a pitola role in the onset and development
of HCC
- Discussion section: i suggests to report the pivotal role played by metabolic features in
development of HCC in MAFLD patients
Please review this paper.
user
Title: Impact and usefulness of the transition to the new MAFLD classification for non-B, non-
C HCC: A retrospective cohort study
Version: 0 Date: 11 Apr 2023
Reviewer:  Ludovico Abenavoli
Reviewer's report:
The aim of the article is to evaluate the clinical characteristics of patients with MAFLD and
HCC)in comparison with those with NAFLD and considered the validity and challenges of the
new criteria. The article is interesting and updated. I found the following suggestions for the
Author:
- Introduction section: HCC is a typical example of a virus-related cancer, it is also well known
to be strongly related to life style. Chronic alcoholism is a classic risk factor. However, more
recently, obesity has been recognized to strongly affect HCC development in males, versus
various other tumors. There is also growing evidences suggesting that type 2 diabetes increases
the incidence of HCC. Due to the globally increasing proportion of the obese people, obesity-
related HCC will likely continue to increased (PMID: 32582865)
- Methods section: is important to underline in thi section the alcohol consumption definition
degree of the included patients.  Alcohol intake play a pitola role in the onset and development
of HCC
- Discussion section: i suggests to report the pivotal role played by metabolic features in
development of HCC in MAFLD patients
assistant