Title: Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal
flora
Version: 1 Date: 28 Nov 2024
Reviewer's report:
The paper by Dr. Shasha Cui describes Helicobacter pylori CagA+ strain infection induced
inflammation and histological disorganization as well as dysbiosis. This study might shed light
on investigation therapy of colorectal lesion but some of the methods need to be clarified.
1. It is general understanding Helicobacter pylori CagA+ strain induce inflammation and
colorectal cancer. Please clarify what significance is in figure 1 and 2.
2. Giemsa control staining histology looks different location compared with other staining.
3. It is unclear MHC2 positive cells.
4. Please add p value in figure 3 and 5.
5. It seems there are not difference between 2 cluster. (figure 4b)
Title: Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal
flora
Version: 1 Date: 28 Nov 2024
Reviewer's report:
The paper by Dr. Shasha Cui describes Helicobacter pylori CagA+ strain infection induced
inflammation and histological disorganization as well as dysbiosis. This study might shed light
on investigation therapy of colorectal lesion but some of the methods need to be clarified.
1. It is general understanding Helicobacter pylori CagA+ strain induce inflammation and
colorectal cancer. Please clarify what significance is in figure 1 and 2.
2. Giemsa control staining histology looks different location compared with other staining.
3. It is unclear MHC2 positive cells.
4. Please add p value in figure 3 and 5.
5. It seems there are not difference between 2 cluster. (figure 4b)
Please review this paper.
user
Title: Helicobacter pylori CagA+ strains modulate colorectal pathology by regulating intestinal
flora
Version: 1 Date: 28 Nov 2024
Reviewer's report:
The paper by Dr. Shasha Cui describes Helicobacter pylori CagA+ strain infection induced
inflammation and histological disorganization as well as dysbiosis. This study might shed light
on investigation therapy of colorectal lesion but some of the methods need to be clarified.
1. It is general understanding Helicobacter pylori CagA+ strain induce inflammation and
colorectal cancer. Please clarify what significance is in figure 1 and 2.
2. Giemsa control staining histology looks different location compared with other staining.
3. It is unclear MHC2 positive cells.
4. Please add p value in figure 3 and 5.
5. It seems there are not difference between 2 cluster. (figure 4b)
assistant