Reviewer's report
Title:Loss of PTEN expression is associated with colorectal cancer liver
metastasis and poor patient survival
Version: 3Date:29 July 2008
Reviewer: John Mariadason
Reviewer's report:
The author’s continue to conclude that PTEN is downregulated in liver
metastases, however PTEN staining in only a single liver met is shown in Figure
1. It is not clear how many paired samples were examined and how the authors
arrived at this conclusion. Statistical analyses to support this conclusion are not
provided.
In response to the previous comment the authors state that strong cytoplasmic
PTEN expression and weak nuclear expression was observed. However, as
pointed out in the original critique, the image shown in Figure 1 shows exactly the
opposite.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Loss of PTEN expression is associated with colorectal cancer liver
metastasis and poor patient survival
Version: 3Date:29 July 2008
Reviewer: John Mariadason
Reviewer's report:
The author’s continue to conclude that PTEN is downregulated in liver
metastases, however PTEN staining in only a single liver met is shown in Figure
1. It is not clear how many paired samples were examined and how the authors
arrived at this conclusion. Statistical analyses to support this conclusion are not
provided.
In response to the previous comment the authors state that strong cytoplasmic
PTEN expression and weak nuclear expression was observed. However, as
pointed out in the original critique, the image shown in Figure 1 shows exactly the
opposite.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Loss of PTEN expression is associated with colorectal cancer liver
metastasis and poor patient survival
Version: 3Date:29 July 2008
Reviewer: John Mariadason
Reviewer's report:
The author’s continue to conclude that PTEN is downregulated in liver
metastases, however PTEN staining in only a single liver met is shown in Figure
1. It is not clear how many paired samples were examined and how the authors
arrived at this conclusion. Statistical analyses to support this conclusion are not
provided.
In response to the previous comment the authors state that strong cytoplasmic
PTEN expression and weak nuclear expression was observed. However, as
pointed out in the original critique, the image shown in Figure 1 shows exactly the
opposite.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant