Reviewer's report
Title:HBV DNA level, not liver stiffness value, could predict significant liver
fibrosis in HBeAg negative chronic hepatitis B patients with liver biopsy indication
as AASLD and APASL guidelines
Version:2Date:18 October 2014
Reviewer: Vincent Wong
Reviewer's report:
This is a well-written article on a clinically relevant topic. Current guidelines
suggest liver biopsy in different patient groups. However, due to the large
number of patients in endemic areas, this is often unrealistic. Although the
sample size of this study is small, this point has been adequately addressed in
the discussion.
Specific points:
1. How many pathologists were involved in the interpretation of liver histology?
2. Please quality indicators of the liver biopsy samples such as the length of liver
samples and the number of portal tracts.
3. Please report the quality of liver stiffness measurements.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have served as a speaker for Echosens.
Reviewer's report
Title:HBV DNA level, not liver stiffness value, could predict significant liver
fibrosis in HBeAg negative chronic hepatitis B patients with liver biopsy indication
as AASLD and APASL guidelines
Version:2Date:18 October 2014
Reviewer: Vincent Wong
Reviewer's report:
This is a well-written article on a clinically relevant topic. Current guidelines
suggest liver biopsy in different patient groups. However, due to the large
number of patients in endemic areas, this is often unrealistic. Although the
sample size of this study is small, this point has been adequately addressed in
the discussion.
Specific points:
1. How many pathologists were involved in the interpretation of liver histology?
2. Please quality indicators of the liver biopsy samples such as the length of liver
samples and the number of portal tracts.
3. Please report the quality of liver stiffness measurements.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have served as a speaker for Echosens.
Please review this paper.
user
Reviewer's report
Title:HBV DNA level, not liver stiffness value, could predict significant liver
fibrosis in HBeAg negative chronic hepatitis B patients with liver biopsy indication
as AASLD and APASL guidelines
Version:2Date:18 October 2014
Reviewer: Vincent Wong
Reviewer's report:
This is a well-written article on a clinically relevant topic. Current guidelines
suggest liver biopsy in different patient groups. However, due to the large
number of patients in endemic areas, this is often unrealistic. Although the
sample size of this study is small, this point has been adequately addressed in
the discussion.
Specific points:
1. How many pathologists were involved in the interpretation of liver histology?
2. Please quality indicators of the liver biopsy samples such as the length of liver
samples and the number of portal tracts.
3. Please report the quality of liver stiffness measurements.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have served as a speaker for Echosens.
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