Title: Clinico-pathological study of esophageal mucoepidermoid carcinoma: a 10-year survival
from a single center
Version: 1 Date: 08 Sep 2023
Reviewer:  Junya Oguma
Reviewer's report:
I am grateful for the opportunity to review your interesting manuscript entitled: "Clinico-
pathological study of esophageal mucoepidermoid carcinoma: a 10-year survival from a single
center". This report is interesting because it focused on the clinicopathological features of MEC
of the esophagus which is one of the rare histological type of esophageal cancer. However, your
manuscript has several major problems as following.
1. MEC is one of rare malignancy in the esophagus, but I cannot find any novel information
in your manuscript compared to previous reports. We want to know the difference of
clinical characteristics between MEC and SCC. You had better compare clinical features and
postoperative outcomes between these two histological types using propensity score matched
analysis.
2. The average number of resected LN was 11.2, and it was not enough for thoracic esophageal
cancer. I think that sweet approach, which was performed for 42 patients, is not suitable for upper
and middle thoracic esophageal cancer, because sufficient upper mediastinal LN dissection
cannot be undergone during sweet procedure.
3. In your cohort, neoadjuvant chemotherapy was performed for 3 cases and adjuvant
chemotherapy was performed for 17 cases. You should clear the indication of these adjuvant
therapy.
4. You mentioned that 17 patients had LN metastasis. Was histological type of metastatic lesions
MEC or another type?
Title: Clinico-pathological study of esophageal mucoepidermoid carcinoma: a 10-year survival
from a single center
Version: 1 Date: 08 Sep 2023
Reviewer:  Junya Oguma
Reviewer's report:
I am grateful for the opportunity to review your interesting manuscript entitled: "Clinico-
pathological study of esophageal mucoepidermoid carcinoma: a 10-year survival from a single
center". This report is interesting because it focused on the clinicopathological features of MEC
of the esophagus which is one of the rare histological type of esophageal cancer. However, your
manuscript has several major problems as following.
1. MEC is one of rare malignancy in the esophagus, but I cannot find any novel information
in your manuscript compared to previous reports. We want to know the difference of
clinical characteristics between MEC and SCC. You had better compare clinical features and
postoperative outcomes between these two histological types using propensity score matched
analysis.
2. The average number of resected LN was 11.2, and it was not enough for thoracic esophageal
cancer. I think that sweet approach, which was performed for 42 patients, is not suitable for upper
and middle thoracic esophageal cancer, because sufficient upper mediastinal LN dissection
cannot be undergone during sweet procedure.
3. In your cohort, neoadjuvant chemotherapy was performed for 3 cases and adjuvant
chemotherapy was performed for 17 cases. You should clear the indication of these adjuvant
therapy.
4. You mentioned that 17 patients had LN metastasis. Was histological type of metastatic lesions
MEC or another type?
Please review this paper.
user
Title: Clinico-pathological study of esophageal mucoepidermoid carcinoma: a 10-year survival
from a single center
Version: 1 Date: 08 Sep 2023
Reviewer:  Junya Oguma
Reviewer's report:
I am grateful for the opportunity to review your interesting manuscript entitled: "Clinico-
pathological study of esophageal mucoepidermoid carcinoma: a 10-year survival from a single
center". This report is interesting because it focused on the clinicopathological features of MEC
of the esophagus which is one of the rare histological type of esophageal cancer. However, your
manuscript has several major problems as following.
1. MEC is one of rare malignancy in the esophagus, but I cannot find any novel information
in your manuscript compared to previous reports. We want to know the difference of
clinical characteristics between MEC and SCC. You had better compare clinical features and
postoperative outcomes between these two histological types using propensity score matched
analysis.
2. The average number of resected LN was 11.2, and it was not enough for thoracic esophageal
cancer. I think that sweet approach, which was performed for 42 patients, is not suitable for upper
and middle thoracic esophageal cancer, because sufficient upper mediastinal LN dissection
cannot be undergone during sweet procedure.
3. In your cohort, neoadjuvant chemotherapy was performed for 3 cases and adjuvant
chemotherapy was performed for 17 cases. You should clear the indication of these adjuvant
therapy.
4. You mentioned that 17 patients had LN metastasis. Was histological type of metastatic lesions
MEC or another type?
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