Title: Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis
Version: 4 Date: 08 May 2024
Reviewer's report:
The authors studied the pathogenesis of ferroptosis in SAP. This article suggested that ferroptosis
was a novel pathogenesis of SAP and is dependent on autophagy. However, autophagy
mediated ferroptosis has been reported (doi: 10.1080/15548627.2022.2152209). Ferroptosis
inhibitor has already known to protect SAP (doi: 10.1038/s41419-023-06216-x, 10.1016/
j.intimp.2024.111495). Therefore, the aim of this study is not clear. Moreover, many of the
images were not qualified for publication including IF pictures and WB blots.
Title: Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis
Version: 4 Date: 08 May 2024
Reviewer's report:
The authors studied the pathogenesis of ferroptosis in SAP. This article suggested that ferroptosis
was a novel pathogenesis of SAP and is dependent on autophagy. However, autophagy
mediated ferroptosis has been reported (doi: 10.1080/15548627.2022.2152209). Ferroptosis
inhibitor has already known to protect SAP (doi: 10.1038/s41419-023-06216-x, 10.1016/
j.intimp.2024.111495). Therefore, the aim of this study is not clear. Moreover, many of the
images were not qualified for publication including IF pictures and WB blots.
Please review this paper.
user
Title: Autophagy-mediated ferroptosis is involved in development of severe acute pancreatitis
Version: 4 Date: 08 May 2024
Reviewer's report:
The authors studied the pathogenesis of ferroptosis in SAP. This article suggested that ferroptosis
was a novel pathogenesis of SAP and is dependent on autophagy. However, autophagy
mediated ferroptosis has been reported (doi: 10.1080/15548627.2022.2152209). Ferroptosis
inhibitor has already known to protect SAP (doi: 10.1038/s41419-023-06216-x, 10.1016/
j.intimp.2024.111495). Therefore, the aim of this study is not clear. Moreover, many of the
images were not qualified for publication including IF pictures and WB blots.
assistant