Title: Long-term outcomes after enterostomy for very early-onset inflammatory bowel disease
with interleukin-10 signaling deficiency
Version: 2 Date: 29 Sep 2023
Reviewer's report:
This study seems to include the same patient population that has been published previously
Aliment Phaemacol Ther 20223;55:1411-122).  form the same hospital. Even with some
completely similar results as e.g., time from stem cell transplantation to stoma closure (19,6
months). This should have been specified in the Methos section. It is impossible to see what the
indication for stoma-closure was. This would have been an interesting result.
There are several other issues of concern. Why is there no information on stoma closure in
patients without stem cell transplantation? Why were 4 patients without a stoma closure in the
stem cell transplantation group excluded. What is meant by “normal stoma closure group” in
fig. 1.
What were the reasons for choosing 18 months to distinguish between early versus late stoma
closure?
The conclusion is unclear and not based on the results.
Title: Long-term outcomes after enterostomy for very early-onset inflammatory bowel disease
with interleukin-10 signaling deficiency
Version: 2 Date: 29 Sep 2023
Reviewer's report:
This study seems to include the same patient population that has been published previously
Aliment Phaemacol Ther 20223;55:1411-122).  form the same hospital. Even with some
completely similar results as e.g., time from stem cell transplantation to stoma closure (19,6
months). This should have been specified in the Methos section. It is impossible to see what the
indication for stoma-closure was. This would have been an interesting result.
There are several other issues of concern. Why is there no information on stoma closure in
patients without stem cell transplantation? Why were 4 patients without a stoma closure in the
stem cell transplantation group excluded. What is meant by “normal stoma closure group” in
fig. 1.
What were the reasons for choosing 18 months to distinguish between early versus late stoma
closure?
The conclusion is unclear and not based on the results.
Please review this paper.
user
Title: Long-term outcomes after enterostomy for very early-onset inflammatory bowel disease
with interleukin-10 signaling deficiency
Version: 2 Date: 29 Sep 2023
Reviewer's report:
This study seems to include the same patient population that has been published previously
Aliment Phaemacol Ther 20223;55:1411-122).  form the same hospital. Even with some
completely similar results as e.g., time from stem cell transplantation to stoma closure (19,6
months). This should have been specified in the Methos section. It is impossible to see what the
indication for stoma-closure was. This would have been an interesting result.
There are several other issues of concern. Why is there no information on stoma closure in
patients without stem cell transplantation? Why were 4 patients without a stoma closure in the
stem cell transplantation group excluded. What is meant by “normal stoma closure group” in
fig. 1.
What were the reasons for choosing 18 months to distinguish between early versus late stoma
closure?
The conclusion is unclear and not based on the results.
assistant