Title: Steroid-mediated liver steatosis is CD1d-dependent while steroid-induced liver necrosis,
inflammation, and metabolic changes are CD1d-independent
Version: 2 Date: 28 Feb 2022
Reviewer:  Nazmul Huda
Reviewer's report:
Adar et al. have tried to develop a steroid-mediated mouse model  of NAFLD.  Using this model,
they claimed that steroid-mediated  steatosis was CD1d-dependent and the liver inflammation
and necrosis was  CD1d-independent .  This work has some merits for this particular field  of
research. However, the manuscript is not carefully produced. It  has many spelling/grammatical
mistakes. The statistical analysis was not correctly done ( instead of using ANOVA test, they
had used student's t-test for multiple comparison). The figures are not presented professionally.
Some figures do not have error bars. The data look very raw. They have to reproduce all of
the figures.
Title: Steroid-mediated liver steatosis is CD1d-dependent while steroid-induced liver necrosis,
inflammation, and metabolic changes are CD1d-independent
Version: 2 Date: 28 Feb 2022
Reviewer:  Nazmul Huda
Reviewer's report:
Adar et al. have tried to develop a steroid-mediated mouse model  of NAFLD.  Using this model,
they claimed that steroid-mediated  steatosis was CD1d-dependent and the liver inflammation
and necrosis was  CD1d-independent .  This work has some merits for this particular field  of
research. However, the manuscript is not carefully produced. It  has many spelling/grammatical
mistakes. The statistical analysis was not correctly done ( instead of using ANOVA test, they
had used student's t-test for multiple comparison). The figures are not presented professionally.
Some figures do not have error bars. The data look very raw. They have to reproduce all of
the figures.
Please review this paper.
user
Title: Steroid-mediated liver steatosis is CD1d-dependent while steroid-induced liver necrosis,
inflammation, and metabolic changes are CD1d-independent
Version: 2 Date: 28 Feb 2022
Reviewer:  Nazmul Huda
Reviewer's report:
Adar et al. have tried to develop a steroid-mediated mouse model  of NAFLD.  Using this model,
they claimed that steroid-mediated  steatosis was CD1d-dependent and the liver inflammation
and necrosis was  CD1d-independent .  This work has some merits for this particular field  of
research. However, the manuscript is not carefully produced. It  has many spelling/grammatical
mistakes. The statistical analysis was not correctly done ( instead of using ANOVA test, they
had used student's t-test for multiple comparison). The figures are not presented professionally.
Some figures do not have error bars. The data look very raw. They have to reproduce all of
the figures.
assistant