Title: Molecular Analyses of ADAMTS-1, -4, -5, and IL-17A Cytokine Relationship in Patients
with Ulcerative Colitis
Version: 2 Date: 21 Mar 2023
Reviewer's report:
The paper aimes to present the relationship between IL-17A and ADAMTS-1, -4, and -5 protein.
lt is a topic of interest to the researchers in the related areas but the manuscript quality does
not meet the requirements for publication and is recommended rejection. My detailed reasons
are as follows:
# Although it is mentioned that the paper aims to evaluate the relationship between IL-17A and
ADAMTS-1, -4, and -5 proteins in the Abstract and the Introduction , the results in Figure 4
only show the correlation between the expression of the above four proteins in serum and tissue,
respectively.
# The role of IL-17A and ADAMTS-1, -4, and -5 in the development of UC was not specifically
addressed. Obviously, merely assessing the genes exrepression in the disease state does not
reflect its role.
# The patient information provided in Table 1 is too poor.
# The findings presented in the Results are not consistent with Figure 1.
# The size of the line spacing of the manuscript should be consistent.
#6#In the background section, the introduction of the target genes to be studied is too shallow.
Title: Molecular Analyses of ADAMTS-1, -4, -5, and IL-17A Cytokine Relationship in Patients
with Ulcerative Colitis
Version: 2 Date: 21 Mar 2023
Reviewer's report:
The paper aimes to present the relationship between IL-17A and ADAMTS-1, -4, and -5 protein.
lt is a topic of interest to the researchers in the related areas but the manuscript quality does
not meet the requirements for publication and is recommended rejection. My detailed reasons
are as follows:
# Although it is mentioned that the paper aims to evaluate the relationship between IL-17A and
ADAMTS-1, -4, and -5 proteins in the Abstract and the Introduction , the results in Figure 4
only show the correlation between the expression of the above four proteins in serum and tissue,
respectively.
# The role of IL-17A and ADAMTS-1, -4, and -5 in the development of UC was not specifically
addressed. Obviously, merely assessing the genes exrepression in the disease state does not
reflect its role.
# The patient information provided in Table 1 is too poor.
# The findings presented in the Results are not consistent with Figure 1.
# The size of the line spacing of the manuscript should be consistent.
#6#In the background section, the introduction of the target genes to be studied is too shallow.
Please review this paper.
user
Title: Molecular Analyses of ADAMTS-1, -4, -5, and IL-17A Cytokine Relationship in Patients
with Ulcerative Colitis
Version: 2 Date: 21 Mar 2023
Reviewer's report:
The paper aimes to present the relationship between IL-17A and ADAMTS-1, -4, and -5 protein.
lt is a topic of interest to the researchers in the related areas but the manuscript quality does
not meet the requirements for publication and is recommended rejection. My detailed reasons
are as follows:
# Although it is mentioned that the paper aims to evaluate the relationship between IL-17A and
ADAMTS-1, -4, and -5 proteins in the Abstract and the Introduction , the results in Figure 4
only show the correlation between the expression of the above four proteins in serum and tissue,
respectively.
# The role of IL-17A and ADAMTS-1, -4, and -5 in the development of UC was not specifically
addressed. Obviously, merely assessing the genes exrepression in the disease state does not
reflect its role.
# The patient information provided in Table 1 is too poor.
# The findings presented in the Results are not consistent with Figure 1.
# The size of the line spacing of the manuscript should be consistent.
#6#In the background section, the introduction of the target genes to be studied is too shallow.
assistant