Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactose
intolerance is not related to symptomatology
Version: 1Date:31 August 2009
Reviewer: Faiqa Imtiaz
Reviewer's report:
This paper is written clearly and objectively.
Although the authors are addressing and reporting on experimental analysis on a
number of known SNPs in a single hormone, I believe that the results and
implications are of importance to those in the same field.
In addition, the authors found significant differences in genotype frequencies of a
SNP in the promoter region in patients with lactose intolerance whose role is still
unclear, suggests that in the future, further investigation may be warranted of this
gene and it's function.
Major Essential Revisions:
None
Minor Essential Revisisions
1. Introduction- please correct the word 'previosuly' to previously.
2. Please italicize OXTR throughout the manuscript.
Discretionary Revisions
1. Perhaps as a next step, the authors may sequence the entire OXT promoter
region and OXTR gene in a number of patients with lactose intolerance as to
possibly identify novel SNPs?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactose
intolerance is not related to symptomatology
Version: 1Date:31 August 2009
Reviewer: Faiqa Imtiaz
Reviewer's report:
This paper is written clearly and objectively.
Although the authors are addressing and reporting on experimental analysis on a
number of known SNPs in a single hormone, I believe that the results and
implications are of importance to those in the same field.
In addition, the authors found significant differences in genotype frequencies of a
SNP in the promoter region in patients with lactose intolerance whose role is still
unclear, suggests that in the future, further investigation may be warranted of this
gene and it's function.
Major Essential Revisions:
None
Minor Essential Revisisions
1. Introduction- please correct the word 'previosuly' to previously.
2. Please italicize OXTR throughout the manuscript.
Discretionary Revisions
1. Perhaps as a next step, the authors may sequence the entire OXT promoter
region and OXTR gene in a number of patients with lactose intolerance as to
possibly identify novel SNPs?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactose
intolerance is not related to symptomatology
Version: 1Date:31 August 2009
Reviewer: Faiqa Imtiaz
Reviewer's report:
This paper is written clearly and objectively.
Although the authors are addressing and reporting on experimental analysis on a
number of known SNPs in a single hormone, I believe that the results and
implications are of importance to those in the same field.
In addition, the authors found significant differences in genotype frequencies of a
SNP in the promoter region in patients with lactose intolerance whose role is still
unclear, suggests that in the future, further investigation may be warranted of this
gene and it's function.
Major Essential Revisions:
None
Minor Essential Revisisions
1. Introduction- please correct the word 'previosuly' to previously.
2. Please italicize OXTR throughout the manuscript.
Discretionary Revisions
1. Perhaps as a next step, the authors may sequence the entire OXT promoter
region and OXTR gene in a number of patients with lactose intolerance as to
possibly identify novel SNPs?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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