Reviewer's report
Title:The MLH1 2101C>A (Q701K) variation is related to risk of gastric cancer in
Chinese males
Version: 3Date:4 October 2011
Reviewer: Eugenia Flores
Reviewer's report:
The authors have incorporated the corrections to the original document and
properly justified when it was not possible to make changes. Although I have one
last observation, in the abstract document authors should be more careful when
making the following statement on the results: Compared with the MLH1 2101CC
genotype, the 2101CA genotype was associated with a significantly elevated risk
of gastric cancer (OR=8.42, 95% CI =1.04-68.06) in males. Although the
association is significant, is weak, and there is loss in statistical efficiency by a
decrease of n to gender stratification, and possibly will be a biased estimator. I
suggest removing the term significantly elevated.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:The MLH1 2101C>A (Q701K) variation is related to risk of gastric cancer in
Chinese males
Version: 3Date:4 October 2011
Reviewer: Eugenia Flores
Reviewer's report:
The authors have incorporated the corrections to the original document and
properly justified when it was not possible to make changes. Although I have one
last observation, in the abstract document authors should be more careful when
making the following statement on the results: Compared with the MLH1 2101CC
genotype, the 2101CA genotype was associated with a significantly elevated risk
of gastric cancer (OR=8.42, 95% CI =1.04-68.06) in males. Although the
association is significant, is weak, and there is loss in statistical efficiency by a
decrease of n to gender stratification, and possibly will be a biased estimator. I
suggest removing the term significantly elevated.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:The MLH1 2101C>A (Q701K) variation is related to risk of gastric cancer in
Chinese males
Version: 3Date:4 October 2011
Reviewer: Eugenia Flores
Reviewer's report:
The authors have incorporated the corrections to the original document and
properly justified when it was not possible to make changes. Although I have one
last observation, in the abstract document authors should be more careful when
making the following statement on the results: Compared with the MLH1 2101CC
genotype, the 2101CA genotype was associated with a significantly elevated risk
of gastric cancer (OR=8.42, 95% CI =1.04-68.06) in males. Although the
association is significant, is weak, and there is loss in statistical efficiency by a
decrease of n to gender stratification, and possibly will be a biased estimator. I
suggest removing the term significantly elevated.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant