Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 1 Date: 04 Aug 2024
Reviewer's report:
Application of LE8 measures would improve cardiovascular outcomes regardless of the
underlying condition you are evaluating. This study did not compare outcomes of LE8
application measures in patients with and without ALD, Also, LE8 scores in your study were
not evaluated as a direct treatment option for ALD, hence it would be a stretch to suggest that
the LE8 score be applied as an effective treatment for ALD.  You could suggest the LE8 scores
be included in the overall management of patients with ALD, especially as many of them have
both ALD and metabolic associated steatotic liver disease.
Also see attached manuscript for other review comments.
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 1 Date: 04 Aug 2024
Reviewer's report:
Application of LE8 measures would improve cardiovascular outcomes regardless of the
underlying condition you are evaluating. This study did not compare outcomes of LE8
application measures in patients with and without ALD, Also, LE8 scores in your study were
not evaluated as a direct treatment option for ALD, hence it would be a stretch to suggest that
the LE8 score be applied as an effective treatment for ALD.  You could suggest the LE8 scores
be included in the overall management of patients with ALD, especially as many of them have
both ALD and metabolic associated steatotic liver disease.
Also see attached manuscript for other review comments.
Please review this paper.
user
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 1 Date: 04 Aug 2024
Reviewer's report:
Application of LE8 measures would improve cardiovascular outcomes regardless of the
underlying condition you are evaluating. This study did not compare outcomes of LE8
application measures in patients with and without ALD, Also, LE8 scores in your study were
not evaluated as a direct treatment option for ALD, hence it would be a stretch to suggest that
the LE8 score be applied as an effective treatment for ALD.  You could suggest the LE8 scores
be included in the overall management of patients with ALD, especially as many of them have
both ALD and metabolic associated steatotic liver disease.
Also see attached manuscript for other review comments.
assistant