Reviewer's report
Title:Change of nitric oxide synthase neurons in ileal myenteric plexus of rat
severe acute pancreatitis
Version: 1Date:19 April 2011
Reviewer: Chuanyong Liu
Reviewer's report:
Major Compulsory Revisions
Lin et al fond that the intestinal transit decreased and the number of nNOS IR
neurons in ileal myenteric plex increased following acute pancreatitis (FAP)), so
the author concluded that increase of nNOS might be the one of the reasons of
the intestinal dysmotility after FAP. This work is interesting but additional
necessary experiments should be performed.
1. In order to certify that the intestinal dysmotility is, at least partly, contributed to
the increased nNOS expression, the effect of nNOS inhibitor pretreatment before
FAP should be investigated.
2. In order to convince the reader that the intestinal dysmotility of the intestinal
transit is caused by the overproduction of NO following FAP, the concentration of
NO in intestine should be measured.
Minor Essential Revisions
There are too many spelling and grammar errors in the manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests' below
Reviewer's report
Title:Change of nitric oxide synthase neurons in ileal myenteric plexus of rat
severe acute pancreatitis
Version: 1Date:19 April 2011
Reviewer: Chuanyong Liu
Reviewer's report:
Major Compulsory Revisions
Lin et al fond that the intestinal transit decreased and the number of nNOS IR
neurons in ileal myenteric plex increased following acute pancreatitis (FAP)), so
the author concluded that increase of nNOS might be the one of the reasons of
the intestinal dysmotility after FAP. This work is interesting but additional
necessary experiments should be performed.
1. In order to certify that the intestinal dysmotility is, at least partly, contributed to
the increased nNOS expression, the effect of nNOS inhibitor pretreatment before
FAP should be investigated.
2. In order to convince the reader that the intestinal dysmotility of the intestinal
transit is caused by the overproduction of NO following FAP, the concentration of
NO in intestine should be measured.
Minor Essential Revisions
There are too many spelling and grammar errors in the manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests' below
Please review this paper.
user
Reviewer's report
Title:Change of nitric oxide synthase neurons in ileal myenteric plexus of rat
severe acute pancreatitis
Version: 1Date:19 April 2011
Reviewer: Chuanyong Liu
Reviewer's report:
Major Compulsory Revisions
Lin et al fond that the intestinal transit decreased and the number of nNOS IR
neurons in ileal myenteric plex increased following acute pancreatitis (FAP)), so
the author concluded that increase of nNOS might be the one of the reasons of
the intestinal dysmotility after FAP. This work is interesting but additional
necessary experiments should be performed.
1. In order to certify that the intestinal dysmotility is, at least partly, contributed to
the increased nNOS expression, the effect of nNOS inhibitor pretreatment before
FAP should be investigated.
2. In order to convince the reader that the intestinal dysmotility of the intestinal
transit is caused by the overproduction of NO following FAP, the concentration of
NO in intestine should be measured.
Minor Essential Revisions
There are too many spelling and grammar errors in the manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests' below
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