Title: Preoperative Platelet-Lymphocyte Ratio (PLR) as a Prognostic Inflammation Biomarker
in Asian HIV-Infected Patients with Gastric Cancer: A Single-Center Study
Version: 3 Date: 01 Apr 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Not sure - I am not able to assess the statistics in this study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors present a retrospective study to evaluate the prognostic
value of preoperative systemic inflammation biomarkers in Asian HIV-infected patients with
gastric cancer (GC). The study included 41 HIV-infected GC patients who underwent surgery
at the Shanghai Public Health Clinical Center, and 127 GC patients without HIV infection. The
preoperative platelet to lymphocyte ratio (PLR) was measured and patients were divided into two
groups based on the optimal cut-off value. The study found that HIV-infected GC patients had
worse clinical outcomes than the normal GC population. Multivariate Cox regression analysis
revealed that a low PLR was an independent predictor of better overall survival (OS) and
progression-free survival (PFS).
This is a single institute study, and the patient numbers are limited to draw any conclusion.
Also, reviewer 2 pointed out that the authors mentioned CRC (colorectal cancer ) instead of
GC. Although the authors have made the changes in the revised text, there is a question about
the authenticity of the study and the data presented. The authors have responded to the review
comments but did not validate their findings in an independent cohort.
REQUESTED REVISIONS:
The claims in the study are based on single institution and small patient numbers. The results
need to be validated in an independent cohort of GC patients."
Title: Preoperative Platelet-Lymphocyte Ratio (PLR) as a Prognostic Inflammation Biomarker
in Asian HIV-Infected Patients with Gastric Cancer: A Single-Center Study
Version: 3 Date: 01 Apr 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Not sure - I am not able to assess the statistics in this study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors present a retrospective study to evaluate the prognostic
value of preoperative systemic inflammation biomarkers in Asian HIV-infected patients with
gastric cancer (GC). The study included 41 HIV-infected GC patients who underwent surgery
at the Shanghai Public Health Clinical Center, and 127 GC patients without HIV infection. The
preoperative platelet to lymphocyte ratio (PLR) was measured and patients were divided into two
groups based on the optimal cut-off value. The study found that HIV-infected GC patients had
worse clinical outcomes than the normal GC population. Multivariate Cox regression analysis
revealed that a low PLR was an independent predictor of better overall survival (OS) and
progression-free survival (PFS).
This is a single institute study, and the patient numbers are limited to draw any conclusion.
Also, reviewer 2 pointed out that the authors mentioned CRC (colorectal cancer ) instead of
GC. Although the authors have made the changes in the revised text, there is a question about
the authenticity of the study and the data presented. The authors have responded to the review
comments but did not validate their findings in an independent cohort.
REQUESTED REVISIONS:
The claims in the study are based on single institution and small patient numbers. The results
need to be validated in an independent cohort of GC patients."
Please review this paper.
user
Title: Preoperative Platelet-Lymphocyte Ratio (PLR) as a Prognostic Inflammation Biomarker
in Asian HIV-Infected Patients with Gastric Cancer: A Single-Center Study
Version: 3 Date: 01 Apr 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Not sure - I am not able to assess the statistics in this study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors present a retrospective study to evaluate the prognostic
value of preoperative systemic inflammation biomarkers in Asian HIV-infected patients with
gastric cancer (GC). The study included 41 HIV-infected GC patients who underwent surgery
at the Shanghai Public Health Clinical Center, and 127 GC patients without HIV infection. The
preoperative platelet to lymphocyte ratio (PLR) was measured and patients were divided into two
groups based on the optimal cut-off value. The study found that HIV-infected GC patients had
worse clinical outcomes than the normal GC population. Multivariate Cox regression analysis
revealed that a low PLR was an independent predictor of better overall survival (OS) and
progression-free survival (PFS).
This is a single institute study, and the patient numbers are limited to draw any conclusion.
Also, reviewer 2 pointed out that the authors mentioned CRC (colorectal cancer ) instead of
GC. Although the authors have made the changes in the revised text, there is a question about
the authenticity of the study and the data presented. The authors have responded to the review
comments but did not validate their findings in an independent cohort.
REQUESTED REVISIONS:
The claims in the study are based on single institution and small patient numbers. The results
need to be validated in an independent cohort of GC patients."
assistant