Reviewer's report
Title:Telomere shortening correlates to dysplasia but not to DNA aneuploidy in
longstanding ulcerative colitis
Version: 4Date:1 July 2013
Reviewer: Ferenc Sipos
Reviewer's report:
1. Major compulsory revisions
It is an interesting, well-designed and well-presented study about the association
of telomere-shortening, DNA aneuploidy and dysplasia/cancer development in
ulcerative colitis.
The authors have shown that both the increased amount of ultra-short telomeres,
and the shortening of mean telomere length are significantly associated with
dysplasia in longstanding disease, but no such associations were found between
telomere status and DNA aneuploidy.
Based on thier results it seems that the amount of ultra-short telomeres
may be a more sensitive marker of colitis-associated tumour progression than
mean telomere length.
Their results are new and may explain earlier observations about
telomerase-reverse transcriptase (TERT) expression in ulcerative colitis (Sipos F.
et al, Scand J Gastroenterol. 2008 Mar;43(3):289-98.).
2. Minor essential revisions
--
3. Discretionary revisions
A short (1-2 sentence) discussion about the a possible context between TERT
expression in UC and the found results would give a wider functional aspect of to
the discussion, and would enhance the strenght of the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Telomere shortening correlates to dysplasia but not to DNA aneuploidy in
longstanding ulcerative colitis
Version: 4Date:1 July 2013
Reviewer: Ferenc Sipos
Reviewer's report:
1. Major compulsory revisions
It is an interesting, well-designed and well-presented study about the association
of telomere-shortening, DNA aneuploidy and dysplasia/cancer development in
ulcerative colitis.
The authors have shown that both the increased amount of ultra-short telomeres,
and the shortening of mean telomere length are significantly associated with
dysplasia in longstanding disease, but no such associations were found between
telomere status and DNA aneuploidy.
Based on thier results it seems that the amount of ultra-short telomeres
may be a more sensitive marker of colitis-associated tumour progression than
mean telomere length.
Their results are new and may explain earlier observations about
telomerase-reverse transcriptase (TERT) expression in ulcerative colitis (Sipos F.
et al, Scand J Gastroenterol. 2008 Mar;43(3):289-98.).
2. Minor essential revisions
--
3. Discretionary revisions
A short (1-2 sentence) discussion about the a possible context between TERT
expression in UC and the found results would give a wider functional aspect of to
the discussion, and would enhance the strenght of the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Telomere shortening correlates to dysplasia but not to DNA aneuploidy in
longstanding ulcerative colitis
Version: 4Date:1 July 2013
Reviewer: Ferenc Sipos
Reviewer's report:
1. Major compulsory revisions
It is an interesting, well-designed and well-presented study about the association
of telomere-shortening, DNA aneuploidy and dysplasia/cancer development in
ulcerative colitis.
The authors have shown that both the increased amount of ultra-short telomeres,
and the shortening of mean telomere length are significantly associated with
dysplasia in longstanding disease, but no such associations were found between
telomere status and DNA aneuploidy.
Based on thier results it seems that the amount of ultra-short telomeres
may be a more sensitive marker of colitis-associated tumour progression than
mean telomere length.
Their results are new and may explain earlier observations about
telomerase-reverse transcriptase (TERT) expression in ulcerative colitis (Sipos F.
et al, Scand J Gastroenterol. 2008 Mar;43(3):289-98.).
2. Minor essential revisions
--
3. Discretionary revisions
A short (1-2 sentence) discussion about the a possible context between TERT
expression in UC and the found results would give a wider functional aspect of to
the discussion, and would enhance the strenght of the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant