Title: Big Data Analysis of Influenza Vaccination and Liver Cancer Risk in Hypertensive
Patients: Insights from a Nationwide Population-Based Cohort Study
Version: 1 Date: 22 Jul 2024
Reviewer's report:
This study analyzes data from the Taiwan National Health Insurance Research Database
from 2001 to 2012 and finds that influenza vaccination is linked to a decreased risk of liver
cancer in individuals with hypertension. The writing and statistical analysis in this article are
comprehensive. Still, some questions remain.
The analyzed data only covers the period from 2001 to 2012. Why has more recent data not
been utilized? If updated data is not accessible, the reasons should be clarified in the discussion
section under limitations.
As stated by the author in the abstract, "the protective effect of influenza vaccination against
primary liver cancer in individuals with hypertension remains unclear." Why did the author
choose to investigate the interplay between influenza vaccination, hypertensive patients, and
liver cancer risk, given the lack of strong biological connections?
The research team appears to study cancer risk in chronic disease patients following influenza
vaccination. Their research includes but is not limited to the following papers, all of which
use the same data source, similar statistical analysis methods, and even the same ethical
approval number (approval no. N201804043). I am curious why the author did not undertake a
comprehensive analysis encompassing all chronic diseases (e.g., hypertension, COPD, diabetes)
and all cancers (e.g., lung cancer, liver cancer), instead of dividing it into several smaller studies.
Ref 1. Zheng J Q, Lin C H, Chen C C, et al. Role of annual influenza vaccination against lung
cancer in type 2 diabetic patients from a population-based cohort study[J]. Journal of Clinical
Medicine, 2021, 10(15): 3434.
Ref 2. Chen C C, Wu C H, Lin C H, et al. Influenza vaccination and risk of lung cancer in
patients with chronic kidney disease: a nationwide, population-based cohort study[J]. Cancers,
2022, 14(12): 2926.
Ref 3. Hao W R, Yang T Y, Chen C C, et al. Influenza Vaccination Reduces the Risk of
Liver Cancer in Patients with Chronic Kidney Disease: A Nationwide Population-Based Cohort
Study[J]. Vaccines, 2022, 10(12): 2008.
Ref 4. Jong H C, Zheng J Q, Zheng C M, et al. Effect of Annual Influenza Vaccination on the
Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in
Taiwan[J]. International Journal of Public Health, 2023, 68: 1605370.
Title: Big Data Analysis of Influenza Vaccination and Liver Cancer Risk in Hypertensive
Patients: Insights from a Nationwide Population-Based Cohort Study
Version: 1 Date: 22 Jul 2024
Reviewer's report:
This study analyzes data from the Taiwan National Health Insurance Research Database
from 2001 to 2012 and finds that influenza vaccination is linked to a decreased risk of liver
cancer in individuals with hypertension. The writing and statistical analysis in this article are
comprehensive. Still, some questions remain.
The analyzed data only covers the period from 2001 to 2012. Why has more recent data not
been utilized? If updated data is not accessible, the reasons should be clarified in the discussion
section under limitations.
As stated by the author in the abstract, "the protective effect of influenza vaccination against
primary liver cancer in individuals with hypertension remains unclear." Why did the author
choose to investigate the interplay between influenza vaccination, hypertensive patients, and
liver cancer risk, given the lack of strong biological connections?
The research team appears to study cancer risk in chronic disease patients following influenza
vaccination. Their research includes but is not limited to the following papers, all of which
use the same data source, similar statistical analysis methods, and even the same ethical
approval number (approval no. N201804043). I am curious why the author did not undertake a
comprehensive analysis encompassing all chronic diseases (e.g., hypertension, COPD, diabetes)
and all cancers (e.g., lung cancer, liver cancer), instead of dividing it into several smaller studies.
Ref 1. Zheng J Q, Lin C H, Chen C C, et al. Role of annual influenza vaccination against lung
cancer in type 2 diabetic patients from a population-based cohort study[J]. Journal of Clinical
Medicine, 2021, 10(15): 3434.
Ref 2. Chen C C, Wu C H, Lin C H, et al. Influenza vaccination and risk of lung cancer in
patients with chronic kidney disease: a nationwide, population-based cohort study[J]. Cancers,
2022, 14(12): 2926.
Ref 3. Hao W R, Yang T Y, Chen C C, et al. Influenza Vaccination Reduces the Risk of
Liver Cancer in Patients with Chronic Kidney Disease: A Nationwide Population-Based Cohort
Study[J]. Vaccines, 2022, 10(12): 2008.
Ref 4. Jong H C, Zheng J Q, Zheng C M, et al. Effect of Annual Influenza Vaccination on the
Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in
Taiwan[J]. International Journal of Public Health, 2023, 68: 1605370.
Please review this paper.
user
Title: Big Data Analysis of Influenza Vaccination and Liver Cancer Risk in Hypertensive
Patients: Insights from a Nationwide Population-Based Cohort Study
Version: 1 Date: 22 Jul 2024
Reviewer's report:
This study analyzes data from the Taiwan National Health Insurance Research Database
from 2001 to 2012 and finds that influenza vaccination is linked to a decreased risk of liver
cancer in individuals with hypertension. The writing and statistical analysis in this article are
comprehensive. Still, some questions remain.
The analyzed data only covers the period from 2001 to 2012. Why has more recent data not
been utilized? If updated data is not accessible, the reasons should be clarified in the discussion
section under limitations.
As stated by the author in the abstract, "the protective effect of influenza vaccination against
primary liver cancer in individuals with hypertension remains unclear." Why did the author
choose to investigate the interplay between influenza vaccination, hypertensive patients, and
liver cancer risk, given the lack of strong biological connections?
The research team appears to study cancer risk in chronic disease patients following influenza
vaccination. Their research includes but is not limited to the following papers, all of which
use the same data source, similar statistical analysis methods, and even the same ethical
approval number (approval no. N201804043). I am curious why the author did not undertake a
comprehensive analysis encompassing all chronic diseases (e.g., hypertension, COPD, diabetes)
and all cancers (e.g., lung cancer, liver cancer), instead of dividing it into several smaller studies.
Ref 1. Zheng J Q, Lin C H, Chen C C, et al. Role of annual influenza vaccination against lung
cancer in type 2 diabetic patients from a population-based cohort study[J]. Journal of Clinical
Medicine, 2021, 10(15): 3434.
Ref 2. Chen C C, Wu C H, Lin C H, et al. Influenza vaccination and risk of lung cancer in
patients with chronic kidney disease: a nationwide, population-based cohort study[J]. Cancers,
2022, 14(12): 2926.
Ref 3. Hao W R, Yang T Y, Chen C C, et al. Influenza Vaccination Reduces the Risk of
Liver Cancer in Patients with Chronic Kidney Disease: A Nationwide Population-Based Cohort
Study[J]. Vaccines, 2022, 10(12): 2008.
Ref 4. Jong H C, Zheng J Q, Zheng C M, et al. Effect of Annual Influenza Vaccination on the
Risk of Lung Cancer Among Patients With Hypertension: A Population-Based Cohort Study in
Taiwan[J]. International Journal of Public Health, 2023, 68: 1605370.
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