Title: A Systematic Review of the Epidemiology and Risk Factors for Severity and Recurrence
of Hypertriglyceridemia-Induced Acute Pancreatitis
Version: 0 Date: 04 Jan 2025
Reviewer:  Serghei Covantsev
Reviewer's report:
Thank you for the possibility to review the manuscript titled: “A Systematic Review of the
Epidemiology and Risk Factors for Severity and Recurrence of Hypertriglyceridemia-Induced
Acute Pancreatitis”. The review is on a hot topic since acute pancreatitis is a complicated
condition and a major cause of morbidity and mortality. The systematic review is interesting,
however, requires several improvements:
-Please mention in the introduction section that acute pancreatitis is a potentially fatal condition
if it is severe. Also please mention that this is a risk factor for pancreatic malignancy. These
points are good arguments that make the condition even more important.
-Please comment why the study was limited to a systematic review without a meta-analysis.
This should be indicated in the material and methods section.
-There is no discussion of limitations at the end of the discussion section. One potential limitation
is that there is only one RCT included in the analysis, therefore there is some possibility of
unintentional bias. This is mentioned in the conclusion section. I would recommend transferring
this chapter.
-There is no discussion of risk factors for HTG-AP recurrence in the discussion section. I would
recommend expanding this section since comorbidities are a major risk factor in the development
and progression of the condition.
-The conclusions look more as discussion. The main conclusions of the analysis are indicated
in the abstract: “Smoking history, poor lipid control (TG > 3.1mmol/L), or recurrent
hypertriglyceridemia during follow-up were identified as potential predictors of HTG-AP
recurrence. Our findings indicate a stable global prevalence of HTG-AP within AP patients, but
a notable increase in China, possibly attributed to socio-economic and dietary factors.” I think
these are the main points that are important.
Overall this is an interesting and well-written study, please take into account the
recommendations in the spirit of improving the quality of the submission.
Title: A Systematic Review of the Epidemiology and Risk Factors for Severity and Recurrence
of Hypertriglyceridemia-Induced Acute Pancreatitis
Version: 0 Date: 04 Jan 2025
Reviewer:  Serghei Covantsev
Reviewer's report:
Thank you for the possibility to review the manuscript titled: “A Systematic Review of the
Epidemiology and Risk Factors for Severity and Recurrence of Hypertriglyceridemia-Induced
Acute Pancreatitis”. The review is on a hot topic since acute pancreatitis is a complicated
condition and a major cause of morbidity and mortality. The systematic review is interesting,
however, requires several improvements:
-Please mention in the introduction section that acute pancreatitis is a potentially fatal condition
if it is severe. Also please mention that this is a risk factor for pancreatic malignancy. These
points are good arguments that make the condition even more important.
-Please comment why the study was limited to a systematic review without a meta-analysis.
This should be indicated in the material and methods section.
-There is no discussion of limitations at the end of the discussion section. One potential limitation
is that there is only one RCT included in the analysis, therefore there is some possibility of
unintentional bias. This is mentioned in the conclusion section. I would recommend transferring
this chapter.
-There is no discussion of risk factors for HTG-AP recurrence in the discussion section. I would
recommend expanding this section since comorbidities are a major risk factor in the development
and progression of the condition.
-The conclusions look more as discussion. The main conclusions of the analysis are indicated
in the abstract: “Smoking history, poor lipid control (TG > 3.1mmol/L), or recurrent
hypertriglyceridemia during follow-up were identified as potential predictors of HTG-AP
recurrence. Our findings indicate a stable global prevalence of HTG-AP within AP patients, but
a notable increase in China, possibly attributed to socio-economic and dietary factors.” I think
these are the main points that are important.
Overall this is an interesting and well-written study, please take into account the
recommendations in the spirit of improving the quality of the submission.
Please review this paper.
user
Title: A Systematic Review of the Epidemiology and Risk Factors for Severity and Recurrence
of Hypertriglyceridemia-Induced Acute Pancreatitis
Version: 0 Date: 04 Jan 2025
Reviewer:  Serghei Covantsev
Reviewer's report:
Thank you for the possibility to review the manuscript titled: “A Systematic Review of the
Epidemiology and Risk Factors for Severity and Recurrence of Hypertriglyceridemia-Induced
Acute Pancreatitis”. The review is on a hot topic since acute pancreatitis is a complicated
condition and a major cause of morbidity and mortality. The systematic review is interesting,
however, requires several improvements:
-Please mention in the introduction section that acute pancreatitis is a potentially fatal condition
if it is severe. Also please mention that this is a risk factor for pancreatic malignancy. These
points are good arguments that make the condition even more important.
-Please comment why the study was limited to a systematic review without a meta-analysis.
This should be indicated in the material and methods section.
-There is no discussion of limitations at the end of the discussion section. One potential limitation
is that there is only one RCT included in the analysis, therefore there is some possibility of
unintentional bias. This is mentioned in the conclusion section. I would recommend transferring
this chapter.
-There is no discussion of risk factors for HTG-AP recurrence in the discussion section. I would
recommend expanding this section since comorbidities are a major risk factor in the development
and progression of the condition.
-The conclusions look more as discussion. The main conclusions of the analysis are indicated
in the abstract: “Smoking history, poor lipid control (TG > 3.1mmol/L), or recurrent
hypertriglyceridemia during follow-up were identified as potential predictors of HTG-AP
recurrence. Our findings indicate a stable global prevalence of HTG-AP within AP patients, but
a notable increase in China, possibly attributed to socio-economic and dietary factors.” I think
these are the main points that are important.
Overall this is an interesting and well-written study, please take into account the
recommendations in the spirit of improving the quality of the submission.
assistant