Title: Multicentre prospective study to evaluate effectiveness and safety of gel-forming
and hyaluronic-acid containing chewable tablets as add-on treatment in patients with
gastroesophageal reflux disease (GERD) symptoms and unsatisfying proton pump inhibitor
therapy.
Version: 2 Date: 18 Jul 2023
Reviewer's report:
Thank you the authors for their clarification. Although, this study is a non-interventional design,
they can set the inclusion criteria that compatible with refractory GERD in their protocol to
include only patients who met the standard criteria. As I mention earlier,  it is difficult to convey
the result of this study to clinical practice as the included patients were not standardized.
Title: Multicentre prospective study to evaluate effectiveness and safety of gel-forming
and hyaluronic-acid containing chewable tablets as add-on treatment in patients with
gastroesophageal reflux disease (GERD) symptoms and unsatisfying proton pump inhibitor
therapy.
Version: 2 Date: 18 Jul 2023
Reviewer's report:
Thank you the authors for their clarification. Although, this study is a non-interventional design,
they can set the inclusion criteria that compatible with refractory GERD in their protocol to
include only patients who met the standard criteria. As I mention earlier,  it is difficult to convey
the result of this study to clinical practice as the included patients were not standardized.
Please review this paper.
user
Title: Multicentre prospective study to evaluate effectiveness and safety of gel-forming
and hyaluronic-acid containing chewable tablets as add-on treatment in patients with
gastroesophageal reflux disease (GERD) symptoms and unsatisfying proton pump inhibitor
therapy.
Version: 2 Date: 18 Jul 2023
Reviewer's report:
Thank you the authors for their clarification. Although, this study is a non-interventional design,
they can set the inclusion criteria that compatible with refractory GERD in their protocol to
include only patients who met the standard criteria. As I mention earlier,  it is difficult to convey
the result of this study to clinical practice as the included patients were not standardized.
assistant