Reviewer's report
Title:Follow-up of pediatric celiac disease: Value of antibodies in predicting
mucosal healing, a prospective cohort study.
Version:1Date:9 January 2014
Reviewer: Antonio Picarelli
Reviewer's report:
The work, well done and methodologically correct, presents data that are already
known in the literature, but re-evaluated through the use of ROC analysis.
Minor clarifications are required:
METHODS:
1. which were the clinical reasons that led to the performance of endoscopic
duodenal biopsy?
2. Why are they used different commercial tests? Are there differences between
them in their diagnostic capability?
RESULTS: page 9 and ten, it is claimed that Ema were detected in 18 children
from group B. Twelve of these EMA-positive children showed mucosal healing.
To explain about what that statement was based.
3. Children still had positive EMA ranging from 1:5 to 1:80 despite Marsh of class
0. clarify the correlation, your data, among EMA, TG2-and DGP with the different
degree of the Marsh lesion. Recent literature has shown a different interpretation
of these cases by the use of duodenal mucosa cultures.
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no competing interests in relation to this paper.
Reviewer's report
Title:Follow-up of pediatric celiac disease: Value of antibodies in predicting
mucosal healing, a prospective cohort study.
Version:1Date:9 January 2014
Reviewer: Antonio Picarelli
Reviewer's report:
The work, well done and methodologically correct, presents data that are already
known in the literature, but re-evaluated through the use of ROC analysis.
Minor clarifications are required:
METHODS:
1. which were the clinical reasons that led to the performance of endoscopic
duodenal biopsy?
2. Why are they used different commercial tests? Are there differences between
them in their diagnostic capability?
RESULTS: page 9 and ten, it is claimed that Ema were detected in 18 children
from group B. Twelve of these EMA-positive children showed mucosal healing.
To explain about what that statement was based.
3. Children still had positive EMA ranging from 1:5 to 1:80 despite Marsh of class
0. clarify the correlation, your data, among EMA, TG2-and DGP with the different
degree of the Marsh lesion. Recent literature has shown a different interpretation
of these cases by the use of duodenal mucosa cultures.
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no competing interests in relation to this paper.
Please review this paper.
user
Reviewer's report
Title:Follow-up of pediatric celiac disease: Value of antibodies in predicting
mucosal healing, a prospective cohort study.
Version:1Date:9 January 2014
Reviewer: Antonio Picarelli
Reviewer's report:
The work, well done and methodologically correct, presents data that are already
known in the literature, but re-evaluated through the use of ROC analysis.
Minor clarifications are required:
METHODS:
1. which were the clinical reasons that led to the performance of endoscopic
duodenal biopsy?
2. Why are they used different commercial tests? Are there differences between
them in their diagnostic capability?
RESULTS: page 9 and ten, it is claimed that Ema were detected in 18 children
from group B. Twelve of these EMA-positive children showed mucosal healing.
To explain about what that statement was based.
3. Children still had positive EMA ranging from 1:5 to 1:80 despite Marsh of class
0. clarify the correlation, your data, among EMA, TG2-and DGP with the different
degree of the Marsh lesion. Recent literature has shown a different interpretation
of these cases by the use of duodenal mucosa cultures.
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no competing interests in relation to this paper.
assistant