Title: Comorbid Psychiatric Disorders and Long-Term Survival after Liver Transplantation in
Transplant Facilities with a Psychiatric Consultation-Liaison Team: a Multicenter Retrospective
Study
Version: 1 Date: 07 Dec 2022
Reviewer's report:
The study evaluates the impact of psychiatric disorders on the outcome of liver transplantation in
the short and medium term in a retrospective study conducted in eight Liver Transplant Centers
with proven consultation-liaison psychiatry programs.
This study concludes that ad the multivariate analysis, the presence of psychiatric disorders did
not impact survival in the post-transplant.
The first observation was the relatively low rate of psychiatric disorders observed in the liver
transplant population studied. This result may be related to a very low prevalence of alcoholic
liver disease; in this population, HBV and HCV-related diseases were the prevalent cause of
liver disease.
The second reason could be the recruiting modality; during the pre-transplant period, the
psychiatric and psychologic team evaluated not all patients but only those with a previous
history of psychiatric disorders. In the post-transplant, psychiatrists evaluated patients only in
the presence of signs or symptoms of psychiatric disorders.
This approach could result in the loss of many psychiatric diagnoses in the control group and
make the study's conclusions debatable.
Title: Comorbid Psychiatric Disorders and Long-Term Survival after Liver Transplantation in
Transplant Facilities with a Psychiatric Consultation-Liaison Team: a Multicenter Retrospective
Study
Version: 1 Date: 07 Dec 2022
Reviewer's report:
The study evaluates the impact of psychiatric disorders on the outcome of liver transplantation in
the short and medium term in a retrospective study conducted in eight Liver Transplant Centers
with proven consultation-liaison psychiatry programs.
This study concludes that ad the multivariate analysis, the presence of psychiatric disorders did
not impact survival in the post-transplant.
The first observation was the relatively low rate of psychiatric disorders observed in the liver
transplant population studied. This result may be related to a very low prevalence of alcoholic
liver disease; in this population, HBV and HCV-related diseases were the prevalent cause of
liver disease.
The second reason could be the recruiting modality; during the pre-transplant period, the
psychiatric and psychologic team evaluated not all patients but only those with a previous
history of psychiatric disorders. In the post-transplant, psychiatrists evaluated patients only in
the presence of signs or symptoms of psychiatric disorders.
This approach could result in the loss of many psychiatric diagnoses in the control group and
make the study's conclusions debatable.
Please review this paper.
user
Title: Comorbid Psychiatric Disorders and Long-Term Survival after Liver Transplantation in
Transplant Facilities with a Psychiatric Consultation-Liaison Team: a Multicenter Retrospective
Study
Version: 1 Date: 07 Dec 2022
Reviewer's report:
The study evaluates the impact of psychiatric disorders on the outcome of liver transplantation in
the short and medium term in a retrospective study conducted in eight Liver Transplant Centers
with proven consultation-liaison psychiatry programs.
This study concludes that ad the multivariate analysis, the presence of psychiatric disorders did
not impact survival in the post-transplant.
The first observation was the relatively low rate of psychiatric disorders observed in the liver
transplant population studied. This result may be related to a very low prevalence of alcoholic
liver disease; in this population, HBV and HCV-related diseases were the prevalent cause of
liver disease.
The second reason could be the recruiting modality; during the pre-transplant period, the
psychiatric and psychologic team evaluated not all patients but only those with a previous
history of psychiatric disorders. In the post-transplant, psychiatrists evaluated patients only in
the presence of signs or symptoms of psychiatric disorders.
This approach could result in the loss of many psychiatric diagnoses in the control group and
make the study's conclusions debatable.
assistant