Title: Influence of low FODMAP-gluten free diet on gut microbiota alterations and symptom
severity in Iranian patients with irritable bowel syndrome
Version: 4 Date: 02 Apr 2021
Reviewer's report:
The study is well structured and well designed, however, minor revision i required.
1) Minor English grammar revision is required. There are several grammatical mistakes.
2) Figures 2, 3 and 4 are considered as repeated information. Please select 2 of them.
3) Low FODMAP diet is considered as a broader dietary restriction than gluten free diet. Usually
only low FODMAP diet is sufficient in decreasing IBS symptoms, so what is the benefit of
adding additional dietary restriction to IBS patients in form of Gluten free diet especially if the
combination showed only 73% response rate (which is the same as low FODMAP diet alone)?
Please elaborate.
4) Why did you use the word microbiome instead of microbiota?
5) Some of the references are old and should be updated. Too many references for an original
article, consider to reduce them.
6) Please use ''original'' articles instead of ''review'' articles for citation when referring to
microbiome changes, for example citation nr. 14.
7)Under discussion, the authors stated that Actinobacterium was non-significantly increased
contra to other studies where dietary changes lead to a reduction in these bacteria. Don't you
think that is it overstated to say that there were contradictions between the results of different
studies since yours showed a non-significant change?
8) Under discussion: The paragraph from lines 282-284 (Therefore, it is noteworthy to
administrate the diet or a combination of diets of choice for gut microbiota-associated disorders
such as IBS in order to normalize the dysbiotic communities of microbiota) should be moved
down to paragraph lines 304-308 (Our data...etc.).
Title: Influence of low FODMAP-gluten free diet on gut microbiota alterations and symptom
severity in Iranian patients with irritable bowel syndrome
Version: 4 Date: 02 Apr 2021
Reviewer's report:
The study is well structured and well designed, however, minor revision i required.
1) Minor English grammar revision is required. There are several grammatical mistakes.
2) Figures 2, 3 and 4 are considered as repeated information. Please select 2 of them.
3) Low FODMAP diet is considered as a broader dietary restriction than gluten free diet. Usually
only low FODMAP diet is sufficient in decreasing IBS symptoms, so what is the benefit of
adding additional dietary restriction to IBS patients in form of Gluten free diet especially if the
combination showed only 73% response rate (which is the same as low FODMAP diet alone)?
Please elaborate.
4) Why did you use the word microbiome instead of microbiota?
5) Some of the references are old and should be updated. Too many references for an original
article, consider to reduce them.
6) Please use ''original'' articles instead of ''review'' articles for citation when referring to
microbiome changes, for example citation nr. 14.
7)Under discussion, the authors stated that Actinobacterium was non-significantly increased
contra to other studies where dietary changes lead to a reduction in these bacteria. Don't you
think that is it overstated to say that there were contradictions between the results of different
studies since yours showed a non-significant change?
8) Under discussion: The paragraph from lines 282-284 (Therefore, it is noteworthy to
administrate the diet or a combination of diets of choice for gut microbiota-associated disorders
such as IBS in order to normalize the dysbiotic communities of microbiota) should be moved
down to paragraph lines 304-308 (Our data...etc.).
Please review this paper.
user
Title: Influence of low FODMAP-gluten free diet on gut microbiota alterations and symptom
severity in Iranian patients with irritable bowel syndrome
Version: 4 Date: 02 Apr 2021
Reviewer's report:
The study is well structured and well designed, however, minor revision i required.
1) Minor English grammar revision is required. There are several grammatical mistakes.
2) Figures 2, 3 and 4 are considered as repeated information. Please select 2 of them.
3) Low FODMAP diet is considered as a broader dietary restriction than gluten free diet. Usually
only low FODMAP diet is sufficient in decreasing IBS symptoms, so what is the benefit of
adding additional dietary restriction to IBS patients in form of Gluten free diet especially if the
combination showed only 73% response rate (which is the same as low FODMAP diet alone)?
Please elaborate.
4) Why did you use the word microbiome instead of microbiota?
5) Some of the references are old and should be updated. Too many references for an original
article, consider to reduce them.
6) Please use ''original'' articles instead of ''review'' articles for citation when referring to
microbiome changes, for example citation nr. 14.
7)Under discussion, the authors stated that Actinobacterium was non-significantly increased
contra to other studies where dietary changes lead to a reduction in these bacteria. Don't you
think that is it overstated to say that there were contradictions between the results of different
studies since yours showed a non-significant change?
8) Under discussion: The paragraph from lines 282-284 (Therefore, it is noteworthy to
administrate the diet or a combination of diets of choice for gut microbiota-associated disorders
such as IBS in order to normalize the dysbiotic communities of microbiota) should be moved
down to paragraph lines 304-308 (Our data...etc.).
assistant