Title: Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing Enterocolitis:
A Retrospective Case-control Study
Version: 2 Date: 16 Mar 2022
Reviewer's report:
Necrotizing enterocolitis (NEC) is the most common and potentially devastating multifactorial
life-threatening condition affecting the gastrointestinal tract (GIT) in premature infants and is a
leading cause of morbidity and mortality in infants born between 23 and 28 weeks of gestation.
Author found that  the NLR  predict preterm NEC along with other biomarkers. Timely NEC
prediction would not only allow for high-risk neonates to receive preventive treatments such as
early exposure to the mother’s colostrum, careful nutritional consideration, use of probiotics,
and increased skin-to-skin care, but also decrease unnecessary antibiotic therapy or even surgical
interventions. There are many factors that can affect the parameter and these have not been
sufficiently addressed.There are many studies in the literature on the subject and there is no
additional contribution.
Title: Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing Enterocolitis:
A Retrospective Case-control Study
Version: 2 Date: 16 Mar 2022
Reviewer's report:
Necrotizing enterocolitis (NEC) is the most common and potentially devastating multifactorial
life-threatening condition affecting the gastrointestinal tract (GIT) in premature infants and is a
leading cause of morbidity and mortality in infants born between 23 and 28 weeks of gestation.
Author found that  the NLR  predict preterm NEC along with other biomarkers. Timely NEC
prediction would not only allow for high-risk neonates to receive preventive treatments such as
early exposure to the mother’s colostrum, careful nutritional consideration, use of probiotics,
and increased skin-to-skin care, but also decrease unnecessary antibiotic therapy or even surgical
interventions. There are many factors that can affect the parameter and these have not been
sufficiently addressed.There are many studies in the literature on the subject and there is no
additional contribution.
Please review this paper.
user
Title: Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing Enterocolitis:
A Retrospective Case-control Study
Version: 2 Date: 16 Mar 2022
Reviewer's report:
Necrotizing enterocolitis (NEC) is the most common and potentially devastating multifactorial
life-threatening condition affecting the gastrointestinal tract (GIT) in premature infants and is a
leading cause of morbidity and mortality in infants born between 23 and 28 weeks of gestation.
Author found that  the NLR  predict preterm NEC along with other biomarkers. Timely NEC
prediction would not only allow for high-risk neonates to receive preventive treatments such as
early exposure to the mother’s colostrum, careful nutritional consideration, use of probiotics,
and increased skin-to-skin care, but also decrease unnecessary antibiotic therapy or even surgical
interventions. There are many factors that can affect the parameter and these have not been
sufficiently addressed.There are many studies in the literature on the subject and there is no
additional contribution.
assistant