Title: Emergency Pancreatoduodenectomy for Non-Traumatic Conditions: A Case Series
Analysis
Version: 3 Date: 06 Mar 2025
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-Although 12 patients underwent emergency surgery, the small sample size of non-traumatic
EPD (9 patients) is a limitation. A larger sample size would allow for more robust conclusions,
particularly when considering complications and mortality rates. The findings may not be
generalizable to a larger population due to this small cohort.
-The manuscript does not include a control group for comparison. A comparison between
patients undergoing non-traumatic EPD and those undergoing elective PD would provide deeper
insights into the effectiveness of emergency surgery compared to scheduled procedures.
-While the paper presents descriptive statistics (age, gender, mortality rates, etc.), more advanced
statistical analysis could strengthen the results. Comparative statistics on complications and
survival rates between non-traumatic and trauma-related EPD would offer more evidence of the
outcomes.
-There is no mention of the long-term follow-up of patients after surgery. Long-term survival
rates, quality of life post-EPD, and potential chronic issues after surgery should be included to
provide a more complete picture of outcomes.
-The paper does not discuss the experience or qualifications of the surgical team. As the
procedure is highly complex, patient outcomes may be influenced by the level of expertise, and
including this information would add context to the findings.
-Although the paper briefly discusses the importance of postoperative management, it could
delve deeper into preoperative resuscitation protocols, especially for patients in shock or with
severe hemorrhage. A better understanding of resuscitative measures before and after surgery
would help readers gauge the overall success of EPD.
-The study focuses on a single institution, which raises concerns about how applicable
the findings are to other medical centers with different resources, expertise, and patient
demographics.
Title: Emergency Pancreatoduodenectomy for Non-Traumatic Conditions: A Case Series
Analysis
Version: 3 Date: 06 Mar 2025
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-Although 12 patients underwent emergency surgery, the small sample size of non-traumatic
EPD (9 patients) is a limitation. A larger sample size would allow for more robust conclusions,
particularly when considering complications and mortality rates. The findings may not be
generalizable to a larger population due to this small cohort.
-The manuscript does not include a control group for comparison. A comparison between
patients undergoing non-traumatic EPD and those undergoing elective PD would provide deeper
insights into the effectiveness of emergency surgery compared to scheduled procedures.
-While the paper presents descriptive statistics (age, gender, mortality rates, etc.), more advanced
statistical analysis could strengthen the results. Comparative statistics on complications and
survival rates between non-traumatic and trauma-related EPD would offer more evidence of the
outcomes.
-There is no mention of the long-term follow-up of patients after surgery. Long-term survival
rates, quality of life post-EPD, and potential chronic issues after surgery should be included to
provide a more complete picture of outcomes.
-The paper does not discuss the experience or qualifications of the surgical team. As the
procedure is highly complex, patient outcomes may be influenced by the level of expertise, and
including this information would add context to the findings.
-Although the paper briefly discusses the importance of postoperative management, it could
delve deeper into preoperative resuscitation protocols, especially for patients in shock or with
severe hemorrhage. A better understanding of resuscitative measures before and after surgery
would help readers gauge the overall success of EPD.
-The study focuses on a single institution, which raises concerns about how applicable
the findings are to other medical centers with different resources, expertise, and patient
demographics.
Please review this paper.
user
Title: Emergency Pancreatoduodenectomy for Non-Traumatic Conditions: A Case Series
Analysis
Version: 3 Date: 06 Mar 2025
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-Although 12 patients underwent emergency surgery, the small sample size of non-traumatic
EPD (9 patients) is a limitation. A larger sample size would allow for more robust conclusions,
particularly when considering complications and mortality rates. The findings may not be
generalizable to a larger population due to this small cohort.
-The manuscript does not include a control group for comparison. A comparison between
patients undergoing non-traumatic EPD and those undergoing elective PD would provide deeper
insights into the effectiveness of emergency surgery compared to scheduled procedures.
-While the paper presents descriptive statistics (age, gender, mortality rates, etc.), more advanced
statistical analysis could strengthen the results. Comparative statistics on complications and
survival rates between non-traumatic and trauma-related EPD would offer more evidence of the
outcomes.
-There is no mention of the long-term follow-up of patients after surgery. Long-term survival
rates, quality of life post-EPD, and potential chronic issues after surgery should be included to
provide a more complete picture of outcomes.
-The paper does not discuss the experience or qualifications of the surgical team. As the
procedure is highly complex, patient outcomes may be influenced by the level of expertise, and
including this information would add context to the findings.
-Although the paper briefly discusses the importance of postoperative management, it could
delve deeper into preoperative resuscitation protocols, especially for patients in shock or with
severe hemorrhage. A better understanding of resuscitative measures before and after surgery
would help readers gauge the overall success of EPD.
-The study focuses on a single institution, which raises concerns about how applicable
the findings are to other medical centers with different resources, expertise, and patient
demographics.
assistant