Title: Non-alcoholic Fatty Liver Disease and Cognitive Function in Middle-aged Adults: The
CARDIA Study
Version: 1 Date: 14 Dec 2020
Reviewer:  Yasushi Honda
Reviewer's report:
Yariv Gerber et al. investigated the association between NAFLD and cognitive function by using
Coronary Artery Risk Development in Young Adults (CARDIA) participants. This manuscript
is very interesting because it had a large number of patients and detailed data. However, there
is one serious problem. Although the authors used CT to diagnose the severity of NAFLD, CT
has insufficient accuracy for mild-to-moderate hepatic steatosis. The authors should investigate
this association using not only CT but also serum biomarkers and biomarker panels.
Title: Non-alcoholic Fatty Liver Disease and Cognitive Function in Middle-aged Adults: The
CARDIA Study
Version: 1 Date: 14 Dec 2020
Reviewer:  Yasushi Honda
Reviewer's report:
Yariv Gerber et al. investigated the association between NAFLD and cognitive function by using
Coronary Artery Risk Development in Young Adults (CARDIA) participants. This manuscript
is very interesting because it had a large number of patients and detailed data. However, there
is one serious problem. Although the authors used CT to diagnose the severity of NAFLD, CT
has insufficient accuracy for mild-to-moderate hepatic steatosis. The authors should investigate
this association using not only CT but also serum biomarkers and biomarker panels.
Please review this paper.
user
Title: Non-alcoholic Fatty Liver Disease and Cognitive Function in Middle-aged Adults: The
CARDIA Study
Version: 1 Date: 14 Dec 2020
Reviewer:  Yasushi Honda
Reviewer's report:
Yariv Gerber et al. investigated the association between NAFLD and cognitive function by using
Coronary Artery Risk Development in Young Adults (CARDIA) participants. This manuscript
is very interesting because it had a large number of patients and detailed data. However, there
is one serious problem. Although the authors used CT to diagnose the severity of NAFLD, CT
has insufficient accuracy for mild-to-moderate hepatic steatosis. The authors should investigate
this association using not only CT but also serum biomarkers and biomarker panels.
assistant