Title: Symptoms and biomarkers associated with undiagnosed celiac seropositivity
Version: 1 Date: 23 Nov 2020
Reviewer's report:
Thanks for studying the topic of asymptomatic CD.
1. Please, refer to the possibility of low iron, normal ferritin iron def. anemia
2. During 4 decades there were some substantial changes in the presenting symptoms, incidence,
serological performances, diagnostic criteria and epidemiology of CD. Please, refer to those
aspects.
3. Did in references 6, 16, 17 the authors measure CD cholesterol levels?
4. Frozen sera, for 4 decades,  could have lost sensitivity of antibodies titers. Did other markers
were included in order to check proteins titers reliability  during a so long period?
5. Is your population homogenous? Are there other Ethnicities (immigrants) that could have
impact the results?
Title: Symptoms and biomarkers associated with undiagnosed celiac seropositivity
Version: 1 Date: 23 Nov 2020
Reviewer's report:
Thanks for studying the topic of asymptomatic CD.
1. Please, refer to the possibility of low iron, normal ferritin iron def. anemia
2. During 4 decades there were some substantial changes in the presenting symptoms, incidence,
serological performances, diagnostic criteria and epidemiology of CD. Please, refer to those
aspects.
3. Did in references 6, 16, 17 the authors measure CD cholesterol levels?
4. Frozen sera, for 4 decades,  could have lost sensitivity of antibodies titers. Did other markers
were included in order to check proteins titers reliability  during a so long period?
5. Is your population homogenous? Are there other Ethnicities (immigrants) that could have
impact the results?
Please review this paper.
user
Title: Symptoms and biomarkers associated with undiagnosed celiac seropositivity
Version: 1 Date: 23 Nov 2020
Reviewer's report:
Thanks for studying the topic of asymptomatic CD.
1. Please, refer to the possibility of low iron, normal ferritin iron def. anemia
2. During 4 decades there were some substantial changes in the presenting symptoms, incidence,
serological performances, diagnostic criteria and epidemiology of CD. Please, refer to those
aspects.
3. Did in references 6, 16, 17 the authors measure CD cholesterol levels?
4. Frozen sera, for 4 decades,  could have lost sensitivity of antibodies titers. Did other markers
were included in order to check proteins titers reliability  during a so long period?
5. Is your population homogenous? Are there other Ethnicities (immigrants) that could have
impact the results?
assistant