Reviewer's report
Title:Design and rationale of the HCC BRIDGE study in China: a longitudinal,
multicenter cohort trial in hepatocellular carcinoma
Version: 1Date:22 February 2011
Reviewer: Markus Buchler
Reviewer's report:
Dear Sir,
The article entitled “Design and rationale of the HCC BRIDGE study in China: a
longitudinal, multicenter cohort trial in hepatocellular carcinoma” has been
reviewed. This is an interesting cohort trial topic. With appreciation to the authors’
efforts, the requested questions are answered below:
1. Will the study design adequately test the hypothesis?
Yes. It has been well designed and the idea had been good, especially due to the
increasing rate of HCC due to viral cirrhosis.
2. Are sufficient details provided to allow replication of the work or comparison
with related analyses: if not, what is missing?
Yes. Due to handling a large number of cases using a longitudinal multicentre
cohort, we suggest that the article should be also evaluated by a medical
statistician.
3. Does the manuscript adhere to the relevant standards for reporting and data
deposition: if not, in what ways?
Yes. The manuscript considers the relevant standards to report the data.
4. Is the writing acceptable?
Somehow, but despite having a good structure, the method of the writing was
sometimes not good due to using a lot of strange words and phrases as well as
incorrect use of prepositions, denoting and tenses. Moreover, some sentences
are really too long, which distract the readers. The manuscript will profit by
editing by a native speaker.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Design and rationale of the HCC BRIDGE study in China: a longitudinal,
multicenter cohort trial in hepatocellular carcinoma
Version: 1Date:22 February 2011
Reviewer: Markus Buchler
Reviewer's report:
Dear Sir,
The article entitled “Design and rationale of the HCC BRIDGE study in China: a
longitudinal, multicenter cohort trial in hepatocellular carcinoma” has been
reviewed. This is an interesting cohort trial topic. With appreciation to the authors’
efforts, the requested questions are answered below:
1. Will the study design adequately test the hypothesis?
Yes. It has been well designed and the idea had been good, especially due to the
increasing rate of HCC due to viral cirrhosis.
2. Are sufficient details provided to allow replication of the work or comparison
with related analyses: if not, what is missing?
Yes. Due to handling a large number of cases using a longitudinal multicentre
cohort, we suggest that the article should be also evaluated by a medical
statistician.
3. Does the manuscript adhere to the relevant standards for reporting and data
deposition: if not, in what ways?
Yes. The manuscript considers the relevant standards to report the data.
4. Is the writing acceptable?
Somehow, but despite having a good structure, the method of the writing was
sometimes not good due to using a lot of strange words and phrases as well as
incorrect use of prepositions, denoting and tenses. Moreover, some sentences
are really too long, which distract the readers. The manuscript will profit by
editing by a native speaker.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Design and rationale of the HCC BRIDGE study in China: a longitudinal,
multicenter cohort trial in hepatocellular carcinoma
Version: 1Date:22 February 2011
Reviewer: Markus Buchler
Reviewer's report:
Dear Sir,
The article entitled “Design and rationale of the HCC BRIDGE study in China: a
longitudinal, multicenter cohort trial in hepatocellular carcinoma” has been
reviewed. This is an interesting cohort trial topic. With appreciation to the authors’
efforts, the requested questions are answered below:
1. Will the study design adequately test the hypothesis?
Yes. It has been well designed and the idea had been good, especially due to the
increasing rate of HCC due to viral cirrhosis.
2. Are sufficient details provided to allow replication of the work or comparison
with related analyses: if not, what is missing?
Yes. Due to handling a large number of cases using a longitudinal multicentre
cohort, we suggest that the article should be also evaluated by a medical
statistician.
3. Does the manuscript adhere to the relevant standards for reporting and data
deposition: if not, in what ways?
Yes. The manuscript considers the relevant standards to report the data.
4. Is the writing acceptable?
Somehow, but despite having a good structure, the method of the writing was
sometimes not good due to using a lot of strange words and phrases as well as
incorrect use of prepositions, denoting and tenses. Moreover, some sentences
are really too long, which distract the readers. The manuscript will profit by
editing by a native speaker.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
assistant