Reviewer's report
Title:Effects of acotiamide on esophageal motor function and gastroesophageal
reflux in healthy volunteers
Version:2Date:31 May 2015
Reviewer: Kenji Nagahama
Reviewer's report:
This is a nicely written paper summarizing the results of studies assessing the
effects of acotiamide on esophageal motor functions and gastroesophageal
reflux.
However, several issues discussed below need clarification.
Discretionary Revisions:
1) (There are no comments.)
Minor Essential Revisions:
1) Throughout the manuscript. “empting” is misspelled.
2) Abstract-Background (p 3, line 8). Indication of acotiamide (i.e., for the
treatment of functional dyspepsia (FD)) is unclear.
3) Abstract-Conclusions (p 4, line 3). Drug classification of acotiamide may be
better understood as a novel gastrointestinal motility modulator (not gastric)
based on pharmacological feature.
4) Background (p 5, line 4). Please add space between “5-10%” and “in”.
5) Background (p 6, line 2). Enrolled subjects in the present study (i.e., healthy
adults) are unclear.
6) Method-Study Protocol (p 7, line 19). Detailed information of acotiamide is
insufficient. Please add product information (e.g., product name, manufacturer).
7) Discussion (p 15, line 4 and 6). Please reconfirm the use of a term “GERD”.
8) Discussion (p 18, line 11)- larger studies of FD patients with GERD symptoms.
It is known that there is considerable overlap of symptoms among patients with
FD and GERD. Please refer to this point within the manuscript.
Major Compulsory Revisions:
1) (There are no comments.)
I hope these comments will be helpful.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Effects of acotiamide on esophageal motor function and gastroesophageal
reflux in healthy volunteers
Version:2Date:31 May 2015
Reviewer: Kenji Nagahama
Reviewer's report:
This is a nicely written paper summarizing the results of studies assessing the
effects of acotiamide on esophageal motor functions and gastroesophageal
reflux.
However, several issues discussed below need clarification.
Discretionary Revisions:
1) (There are no comments.)
Minor Essential Revisions:
1) Throughout the manuscript. “empting” is misspelled.
2) Abstract-Background (p 3, line 8). Indication of acotiamide (i.e., for the
treatment of functional dyspepsia (FD)) is unclear.
3) Abstract-Conclusions (p 4, line 3). Drug classification of acotiamide may be
better understood as a novel gastrointestinal motility modulator (not gastric)
based on pharmacological feature.
4) Background (p 5, line 4). Please add space between “5-10%” and “in”.
5) Background (p 6, line 2). Enrolled subjects in the present study (i.e., healthy
adults) are unclear.
6) Method-Study Protocol (p 7, line 19). Detailed information of acotiamide is
insufficient. Please add product information (e.g., product name, manufacturer).
7) Discussion (p 15, line 4 and 6). Please reconfirm the use of a term “GERD”.
8) Discussion (p 18, line 11)- larger studies of FD patients with GERD symptoms.
It is known that there is considerable overlap of symptoms among patients with
FD and GERD. Please refer to this point within the manuscript.
Major Compulsory Revisions:
1) (There are no comments.)
I hope these comments will be helpful.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Effects of acotiamide on esophageal motor function and gastroesophageal
reflux in healthy volunteers
Version:2Date:31 May 2015
Reviewer: Kenji Nagahama
Reviewer's report:
This is a nicely written paper summarizing the results of studies assessing the
effects of acotiamide on esophageal motor functions and gastroesophageal
reflux.
However, several issues discussed below need clarification.
Discretionary Revisions:
1) (There are no comments.)
Minor Essential Revisions:
1) Throughout the manuscript. “empting” is misspelled.
2) Abstract-Background (p 3, line 8). Indication of acotiamide (i.e., for the
treatment of functional dyspepsia (FD)) is unclear.
3) Abstract-Conclusions (p 4, line 3). Drug classification of acotiamide may be
better understood as a novel gastrointestinal motility modulator (not gastric)
based on pharmacological feature.
4) Background (p 5, line 4). Please add space between “5-10%” and “in”.
5) Background (p 6, line 2). Enrolled subjects in the present study (i.e., healthy
adults) are unclear.
6) Method-Study Protocol (p 7, line 19). Detailed information of acotiamide is
insufficient. Please add product information (e.g., product name, manufacturer).
7) Discussion (p 15, line 4 and 6). Please reconfirm the use of a term “GERD”.
8) Discussion (p 18, line 11)- larger studies of FD patients with GERD symptoms.
It is known that there is considerable overlap of symptoms among patients with
FD and GERD. Please refer to this point within the manuscript.
Major Compulsory Revisions:
1) (There are no comments.)
I hope these comments will be helpful.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
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