Reviewer's report
Title:White cell count and platelet count associate with histological alcoholic
hepatitis in jaundiced harmful drinkers
Version: 2Date:24 November 2012
Reviewer: Jochen Hampe
Reviewer's report:
Major compulsory revisions:
1. ASAT (GOT) values are not reported - thus is very unusual given alcoholic
liver disease is investigated.
2. A logistic regression model using ASAT as a convential activity marker as a
baseline model +/- platlet count and the appropriate backward selection models
should be used to formally look for the superiority of either (also WBC and
platelet count parameters)
3. only scarce information on the histological severity is available: one could for
instance do a direct pair-wise correllation analysis of histological inflammation
versus clinical predictors and look for groups based on histological inflammation
grade etc.
4. What about fibrosis: do patients with histological fibrosis also show this pattern
of laboratory abmormalities?
Minor: multiple small typos, missing spaces etc.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Reviewer's report
Title:White cell count and platelet count associate with histological alcoholic
hepatitis in jaundiced harmful drinkers
Version: 2Date:24 November 2012
Reviewer: Jochen Hampe
Reviewer's report:
Major compulsory revisions:
1. ASAT (GOT) values are not reported - thus is very unusual given alcoholic
liver disease is investigated.
2. A logistic regression model using ASAT as a convential activity marker as a
baseline model +/- platlet count and the appropriate backward selection models
should be used to formally look for the superiority of either (also WBC and
platelet count parameters)
3. only scarce information on the histological severity is available: one could for
instance do a direct pair-wise correllation analysis of histological inflammation
versus clinical predictors and look for groups based on histological inflammation
grade etc.
4. What about fibrosis: do patients with histological fibrosis also show this pattern
of laboratory abmormalities?
Minor: multiple small typos, missing spaces etc.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Please review this paper.
user
Reviewer's report
Title:White cell count and platelet count associate with histological alcoholic
hepatitis in jaundiced harmful drinkers
Version: 2Date:24 November 2012
Reviewer: Jochen Hampe
Reviewer's report:
Major compulsory revisions:
1. ASAT (GOT) values are not reported - thus is very unusual given alcoholic
liver disease is investigated.
2. A logistic regression model using ASAT as a convential activity marker as a
baseline model +/- platlet count and the appropriate backward selection models
should be used to formally look for the superiority of either (also WBC and
platelet count parameters)
3. only scarce information on the histological severity is available: one could for
instance do a direct pair-wise correllation analysis of histological inflammation
versus clinical predictors and look for groups based on histological inflammation
grade etc.
4. What about fibrosis: do patients with histological fibrosis also show this pattern
of laboratory abmormalities?
Minor: multiple small typos, missing spaces etc.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
assistant