Reviewer's report
Title:A non-interventional study of the genetic polymorphisms of NOD2
associated with increased mortality in non-alcoholic liver transplant patients
Version:1Date:10 November 2013
Reviewer: Siew Ng
Reviewer's report:
Potentially clinically relevant study to use NOD 2 SNPs for patient prognosis
Major compulsory revisions
There was no mention of why the authors chose to test in particularly the 13
SNPs in this study.
It is unclear how many subject in total had non alcoholic disease and the sample
size should be justified
Were confounding factors including age, severity etc adjusted for between the
groups?
Minor Essential revisions
The abstract conclusion of the use of pre-operative tracking of NOD 2 SNPs as a
tool for follow-up of patient appear premature as these SNPs need to be
validated I larger cohort
The discussion can be trimmed down and be more focused and targeted at the
results.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare I have no competing interests
Reviewer's report
Title:A non-interventional study of the genetic polymorphisms of NOD2
associated with increased mortality in non-alcoholic liver transplant patients
Version:1Date:10 November 2013
Reviewer: Siew Ng
Reviewer's report:
Potentially clinically relevant study to use NOD 2 SNPs for patient prognosis
Major compulsory revisions
There was no mention of why the authors chose to test in particularly the 13
SNPs in this study.
It is unclear how many subject in total had non alcoholic disease and the sample
size should be justified
Were confounding factors including age, severity etc adjusted for between the
groups?
Minor Essential revisions
The abstract conclusion of the use of pre-operative tracking of NOD 2 SNPs as a
tool for follow-up of patient appear premature as these SNPs need to be
validated I larger cohort
The discussion can be trimmed down and be more focused and targeted at the
results.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare I have no competing interests
Please review this paper.
user
Reviewer's report
Title:A non-interventional study of the genetic polymorphisms of NOD2
associated with increased mortality in non-alcoholic liver transplant patients
Version:1Date:10 November 2013
Reviewer: Siew Ng
Reviewer's report:
Potentially clinically relevant study to use NOD 2 SNPs for patient prognosis
Major compulsory revisions
There was no mention of why the authors chose to test in particularly the 13
SNPs in this study.
It is unclear how many subject in total had non alcoholic disease and the sample
size should be justified
Were confounding factors including age, severity etc adjusted for between the
groups?
Minor Essential revisions
The abstract conclusion of the use of pre-operative tracking of NOD 2 SNPs as a
tool for follow-up of patient appear premature as these SNPs need to be
validated I larger cohort
The discussion can be trimmed down and be more focused and targeted at the
results.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare I have no competing interests
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