Reviewer's report
Title:Extent of liver inflammation in predicting response to Interferon alpha &
Ribavirin in chronic hepatitis C patients: a cohort study
Version: 1Date:11 June 2011
Reviewer: Masayuki Kurosaki
Reviewer's report:
This study by Mirz et al described the associations between grade of liver
inflammation and response to interferon plus RBV therapy. They also found that
ALT correlated with severe inflammation on liver biopsy.
Majour comment
Liver fibrosis is usually a significant predictor of response to IFN plus RBV
therapy. The authors should show the association between fibrosis and treatment
response. Since inflammation was significantly associated with fibrosis, the
authors should also show that inflammation is an independent predictor of
response by multivariate analysis including fibrosis.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Extent of liver inflammation in predicting response to Interferon alpha &
Ribavirin in chronic hepatitis C patients: a cohort study
Version: 1Date:11 June 2011
Reviewer: Masayuki Kurosaki
Reviewer's report:
This study by Mirz et al described the associations between grade of liver
inflammation and response to interferon plus RBV therapy. They also found that
ALT correlated with severe inflammation on liver biopsy.
Majour comment
Liver fibrosis is usually a significant predictor of response to IFN plus RBV
therapy. The authors should show the association between fibrosis and treatment
response. Since inflammation was significantly associated with fibrosis, the
authors should also show that inflammation is an independent predictor of
response by multivariate analysis including fibrosis.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Extent of liver inflammation in predicting response to Interferon alpha &
Ribavirin in chronic hepatitis C patients: a cohort study
Version: 1Date:11 June 2011
Reviewer: Masayuki Kurosaki
Reviewer's report:
This study by Mirz et al described the associations between grade of liver
inflammation and response to interferon plus RBV therapy. They also found that
ALT correlated with severe inflammation on liver biopsy.
Majour comment
Liver fibrosis is usually a significant predictor of response to IFN plus RBV
therapy. The authors should show the association between fibrosis and treatment
response. Since inflammation was significantly associated with fibrosis, the
authors should also show that inflammation is an independent predictor of
response by multivariate analysis including fibrosis.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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