Title: Serum pepsinogen levels in different regions of China and its influencing factors-a
multicenter cross-sectional study
Version: 1 Date: 27 Feb 2021
Reviewer's report:
TITLE
Serum pepsinogen levels in different regions of China and its influencing factors-a multicenter
cross-sectional study
Authors
Yuling Tong; Hongguang Wang; Yi Zhao; Xueqiang He; Hongwei Xu; Hong Li; Ping Shuai;
Lirong Gong; Hongbo Wu; Hongzhi Xu; Yinhu Luo; Dong Wang1; Shizhu Liu2; Zhenya Song
In their scientific manuscript, the Author further test the predictive value of gastric serology
(Pepsinogen-I-II, and Pepsinogens ratio) in predicting the gastric atrophy-associated cancer risk
The major interest of the achieved results is in the variability of the predicting value of serology
according to the risk factors as registered in different Chinese regions/populations.
This feature (not completely new) is fully supported by the results obtained in the different
populations, as recruited from different Chinese regions (overall study population: 1590
[including 254 individuals from South China, 574 from East China, 210 from Southwest China,
332 from Northeast China, and 220 from Central/Northern China]).
The authors conclude that the cut-off value for PgI/PgII ratio should be adjusted according to the
regional prevalence of H. pylori infection, the socioeconomic, dietary habits, and ethnic profile
of the addressed populations.
When this variability is taken into account, serology may be usefully applied as a subsidiary
method in the initial approach to gastric cancer secondary prevention ultimately increasing the
appropriateness of the endoscopy histology procedures.
The manuscript includes interesting data.
References are basically adequate
Some problems in English editing should be addressed.
While the correlation between histology (OLGA Staging)  and PgI/PgII ratio is expected not
highly informative (due to the “limited” protocol of biopsy sampling), it would have been
interesting to explore the correlation between PgI/PgII ratio and OLGA stages (Low-risk OLGA
0-I-II stages versus High-risk  OLGA III-IV stages; see potential references PMID: 30333540,
PMID: 29306868)
Title: Serum pepsinogen levels in different regions of China and its influencing factors-a
multicenter cross-sectional study
Version: 1 Date: 27 Feb 2021
Reviewer's report:
TITLE
Serum pepsinogen levels in different regions of China and its influencing factors-a multicenter
cross-sectional study
Authors
Yuling Tong; Hongguang Wang; Yi Zhao; Xueqiang He; Hongwei Xu; Hong Li; Ping Shuai;
Lirong Gong; Hongbo Wu; Hongzhi Xu; Yinhu Luo; Dong Wang1; Shizhu Liu2; Zhenya Song
In their scientific manuscript, the Author further test the predictive value of gastric serology
(Pepsinogen-I-II, and Pepsinogens ratio) in predicting the gastric atrophy-associated cancer risk
The major interest of the achieved results is in the variability of the predicting value of serology
according to the risk factors as registered in different Chinese regions/populations.
This feature (not completely new) is fully supported by the results obtained in the different
populations, as recruited from different Chinese regions (overall study population: 1590
[including 254 individuals from South China, 574 from East China, 210 from Southwest China,
332 from Northeast China, and 220 from Central/Northern China]).
The authors conclude that the cut-off value for PgI/PgII ratio should be adjusted according to the
regional prevalence of H. pylori infection, the socioeconomic, dietary habits, and ethnic profile
of the addressed populations.
When this variability is taken into account, serology may be usefully applied as a subsidiary
method in the initial approach to gastric cancer secondary prevention ultimately increasing the
appropriateness of the endoscopy histology procedures.
The manuscript includes interesting data.
References are basically adequate
Some problems in English editing should be addressed.
While the correlation between histology (OLGA Staging)  and PgI/PgII ratio is expected not
highly informative (due to the “limited” protocol of biopsy sampling), it would have been
interesting to explore the correlation between PgI/PgII ratio and OLGA stages (Low-risk OLGA
0-I-II stages versus High-risk  OLGA III-IV stages; see potential references PMID: 30333540,
PMID: 29306868)
Please review this paper.
user
Title: Serum pepsinogen levels in different regions of China and its influencing factors-a
multicenter cross-sectional study
Version: 1 Date: 27 Feb 2021
Reviewer's report:
TITLE
Serum pepsinogen levels in different regions of China and its influencing factors-a multicenter
cross-sectional study
Authors
Yuling Tong; Hongguang Wang; Yi Zhao; Xueqiang He; Hongwei Xu; Hong Li; Ping Shuai;
Lirong Gong; Hongbo Wu; Hongzhi Xu; Yinhu Luo; Dong Wang1; Shizhu Liu2; Zhenya Song
In their scientific manuscript, the Author further test the predictive value of gastric serology
(Pepsinogen-I-II, and Pepsinogens ratio) in predicting the gastric atrophy-associated cancer risk
The major interest of the achieved results is in the variability of the predicting value of serology
according to the risk factors as registered in different Chinese regions/populations.
This feature (not completely new) is fully supported by the results obtained in the different
populations, as recruited from different Chinese regions (overall study population: 1590
[including 254 individuals from South China, 574 from East China, 210 from Southwest China,
332 from Northeast China, and 220 from Central/Northern China]).
The authors conclude that the cut-off value for PgI/PgII ratio should be adjusted according to the
regional prevalence of H. pylori infection, the socioeconomic, dietary habits, and ethnic profile
of the addressed populations.
When this variability is taken into account, serology may be usefully applied as a subsidiary
method in the initial approach to gastric cancer secondary prevention ultimately increasing the
appropriateness of the endoscopy histology procedures.
The manuscript includes interesting data.
References are basically adequate
Some problems in English editing should be addressed.
While the correlation between histology (OLGA Staging)  and PgI/PgII ratio is expected not
highly informative (due to the “limited” protocol of biopsy sampling), it would have been
interesting to explore the correlation between PgI/PgII ratio and OLGA stages (Low-risk OLGA
0-I-II stages versus High-risk  OLGA III-IV stages; see potential references PMID: 30333540,
PMID: 29306868)
assistant