Title: Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021
Version: 1 Date: 25 Apr 2025
Reviewer's report:
The manuscript by Liu et. al. described the global burden of gallbladder and biliary tract cancers
in younger individuals (EOGBTC patients). The data are well presented, and their findings are
relevant for EOGBTC research. A few minor revisions could further strengthen the manuscript.
The discussion is very well written, and the limitations of the study are clearly presented, which
helps to contextualize the findings and makes the interpretation of the results much easier to
follow. It would be interesting to explore why ASIR and ASPR are increasing and ASMR and
ASDR showed downward trends in these patients. Adding some potential explanations (such as
changes in lifestyle, screening practices, or access to healthcare) could provide valuable context
for these trends.
The color scheme of figure 4 is difficult to interpret, as similar color tones are used for countries
within the same region, making it hard to distinguish between them, combining color with shape
or pattern could improve clarity. Also, the text within the plots of figures 4 and 5 are quite small
and difficult to read. Increasing the font size would really help improve the figure's readability.
Title: Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021
Version: 1 Date: 25 Apr 2025
Reviewer's report:
The manuscript by Liu et. al. described the global burden of gallbladder and biliary tract cancers
in younger individuals (EOGBTC patients). The data are well presented, and their findings are
relevant for EOGBTC research. A few minor revisions could further strengthen the manuscript.
The discussion is very well written, and the limitations of the study are clearly presented, which
helps to contextualize the findings and makes the interpretation of the results much easier to
follow. It would be interesting to explore why ASIR and ASPR are increasing and ASMR and
ASDR showed downward trends in these patients. Adding some potential explanations (such as
changes in lifestyle, screening practices, or access to healthcare) could provide valuable context
for these trends.
The color scheme of figure 4 is difficult to interpret, as similar color tones are used for countries
within the same region, making it hard to distinguish between them, combining color with shape
or pattern could improve clarity. Also, the text within the plots of figures 4 and 5 are quite small
and difficult to read. Increasing the font size would really help improve the figure's readability.
Please review this paper.
user
Title: Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021
Version: 1 Date: 25 Apr 2025
Reviewer's report:
The manuscript by Liu et. al. described the global burden of gallbladder and biliary tract cancers
in younger individuals (EOGBTC patients). The data are well presented, and their findings are
relevant for EOGBTC research. A few minor revisions could further strengthen the manuscript.
The discussion is very well written, and the limitations of the study are clearly presented, which
helps to contextualize the findings and makes the interpretation of the results much easier to
follow. It would be interesting to explore why ASIR and ASPR are increasing and ASMR and
ASDR showed downward trends in these patients. Adding some potential explanations (such as
changes in lifestyle, screening practices, or access to healthcare) could provide valuable context
for these trends.
The color scheme of figure 4 is difficult to interpret, as similar color tones are used for countries
within the same region, making it hard to distinguish between them, combining color with shape
or pattern could improve clarity. Also, the text within the plots of figures 4 and 5 are quite small
and difficult to read. Increasing the font size would really help improve the figure's readability.
assistant