Title: Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally
advanced rectal adenocarcinoma
Version: 2 Date: 25 Apr 2024
Reviewer's report:
The authors have performed a systematic review evaluating the association of mucinous
histology with respons to neoadjuvant therapy for rectal cancer
The topic is not new but relevant to professionals treating rectal Cancer. However i do have
some comments;
The title should include the nature of the study ; a systematic review
It is not an offical meta- analysis
Second numerous small mistakes are present througout teh manuscript; rectal cancer is not the
third most common cancer but CRC is
It is not the effect of MAC on CRT response but is a potential association with a poor response
to CRT
The analysis should inlcude OS and DFS  and not only response to  therapy
How many cases have been progressing throughout CRT
Title: Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally
advanced rectal adenocarcinoma
Version: 2 Date: 25 Apr 2024
Reviewer's report:
The authors have performed a systematic review evaluating the association of mucinous
histology with respons to neoadjuvant therapy for rectal cancer
The topic is not new but relevant to professionals treating rectal Cancer. However i do have
some comments;
The title should include the nature of the study ; a systematic review
It is not an offical meta- analysis
Second numerous small mistakes are present througout teh manuscript; rectal cancer is not the
third most common cancer but CRC is
It is not the effect of MAC on CRT response but is a potential association with a poor response
to CRT
The analysis should inlcude OS and DFS  and not only response to  therapy
How many cases have been progressing throughout CRT
Please review this paper.
user
Title: Mucinous histology is a negative predictor of neoadjuvant chemoradiotherapy for locally
advanced rectal adenocarcinoma
Version: 2 Date: 25 Apr 2024
Reviewer's report:
The authors have performed a systematic review evaluating the association of mucinous
histology with respons to neoadjuvant therapy for rectal cancer
The topic is not new but relevant to professionals treating rectal Cancer. However i do have
some comments;
The title should include the nature of the study ; a systematic review
It is not an offical meta- analysis
Second numerous small mistakes are present througout teh manuscript; rectal cancer is not the
third most common cancer but CRC is
It is not the effect of MAC on CRT response but is a potential association with a poor response
to CRT
The analysis should inlcude OS and DFS  and not only response to  therapy
How many cases have been progressing throughout CRT
assistant