Reviewer's report
Title:Fully Covered Self-Expanding Metal Stents Placed Temporarily in the Bile
Duct: Safety Profile and Histologic Classification in a Porcine Model.
Version: 1Date:18 January 2011
Reviewer: Do Hyun Park
Reviewer's report:
As far as this reviewer is aware, this manuscript is the first study regarding
feasibility and histologic analysis of FCSEMS in animal model.
Although this study had a small sample size and frequent distal migration,
therefore, this study seemed to be deserved to publication. This reviewer has a
few of minor comments.
First, numbering of animal (#384, #339...) was appeared to be confusing. Please
provide simple number as #1, and #2.
Second, regarding distal migration, this group may be considered as control or
another group because this distal migration was earlier made (by 41-57 days
after stent deployment).
Third, flared end of stent may have related to more inflammation of bile duct
rather than other part because recent report regarding FCSEMS on pancreatic
duct showed a stent-induced stricture on flared end of FCSEMS (Moon et al.
Gastrointestinal Endoscopy 2010 Jul;72(1):86-91). Thus, separate histologic
analysis according to location of stent would be of interest.
Forth, due to anatomical difference, post-stenting pancreatitis after placement of
FCSEMS could not evaluate this study. Because post-stenting pancreatitis after
placement of FCSEMS may be an important issue on patients with benign biliary
strictures, limitation of this study on this topic may be added in the section of
discussion.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Fully Covered Self-Expanding Metal Stents Placed Temporarily in the Bile
Duct: Safety Profile and Histologic Classification in a Porcine Model.
Version: 1Date:18 January 2011
Reviewer: Do Hyun Park
Reviewer's report:
As far as this reviewer is aware, this manuscript is the first study regarding
feasibility and histologic analysis of FCSEMS in animal model.
Although this study had a small sample size and frequent distal migration,
therefore, this study seemed to be deserved to publication. This reviewer has a
few of minor comments.
First, numbering of animal (#384, #339...) was appeared to be confusing. Please
provide simple number as #1, and #2.
Second, regarding distal migration, this group may be considered as control or
another group because this distal migration was earlier made (by 41-57 days
after stent deployment).
Third, flared end of stent may have related to more inflammation of bile duct
rather than other part because recent report regarding FCSEMS on pancreatic
duct showed a stent-induced stricture on flared end of FCSEMS (Moon et al.
Gastrointestinal Endoscopy 2010 Jul;72(1):86-91). Thus, separate histologic
analysis according to location of stent would be of interest.
Forth, due to anatomical difference, post-stenting pancreatitis after placement of
FCSEMS could not evaluate this study. Because post-stenting pancreatitis after
placement of FCSEMS may be an important issue on patients with benign biliary
strictures, limitation of this study on this topic may be added in the section of
discussion.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Fully Covered Self-Expanding Metal Stents Placed Temporarily in the Bile
Duct: Safety Profile and Histologic Classification in a Porcine Model.
Version: 1Date:18 January 2011
Reviewer: Do Hyun Park
Reviewer's report:
As far as this reviewer is aware, this manuscript is the first study regarding
feasibility and histologic analysis of FCSEMS in animal model.
Although this study had a small sample size and frequent distal migration,
therefore, this study seemed to be deserved to publication. This reviewer has a
few of minor comments.
First, numbering of animal (#384, #339...) was appeared to be confusing. Please
provide simple number as #1, and #2.
Second, regarding distal migration, this group may be considered as control or
another group because this distal migration was earlier made (by 41-57 days
after stent deployment).
Third, flared end of stent may have related to more inflammation of bile duct
rather than other part because recent report regarding FCSEMS on pancreatic
duct showed a stent-induced stricture on flared end of FCSEMS (Moon et al.
Gastrointestinal Endoscopy 2010 Jul;72(1):86-91). Thus, separate histologic
analysis according to location of stent would be of interest.
Forth, due to anatomical difference, post-stenting pancreatitis after placement of
FCSEMS could not evaluate this study. Because post-stenting pancreatitis after
placement of FCSEMS may be an important issue on patients with benign biliary
strictures, limitation of this study on this topic may be added in the section of
discussion.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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