Title: Association of Red Blood Cell Distribution Width with Short- and Long-Term All-Cause
Mortality in Patients with Acute Pancreatitis and Sepsis
Version: 2 Date: 17 May 2025
Reviewer's report:
This study, through statistical analysis of patients with AP complicated by sepsis in the MIMIC-
IV database, revealed the potential value of RDW in the prognosis assessment of AP patients
with sepsis, providing a simple and low-cost predictive tool for clinical practice. It has significant
clinical value. I have several questions and hope to receive the author's answers:
1. For AP patients complicated by sepsis, is the source of infection secondary infection of
pancreatic necrotic tissue or infection of other organs outside the pancreas?
2. What is the statistical basis for grouping using the median RDW value?
3. It is well known that AP patients complicated by sepsis have already developed severe
complications such as IPN or organ failure. Can the proportion of patients with severe AP and
the number of surgical interventions in the two groups after grouping be described?
4. The author only used the first RDW test value after admission and did not analyze the
relationship between its dynamic changes and prognosis, such as the trend of RDW changes at
28 days, 90 days, and 365 days.
Title: Association of Red Blood Cell Distribution Width with Short- and Long-Term All-Cause
Mortality in Patients with Acute Pancreatitis and Sepsis
Version: 2 Date: 17 May 2025
Reviewer's report:
This study, through statistical analysis of patients with AP complicated by sepsis in the MIMIC-
IV database, revealed the potential value of RDW in the prognosis assessment of AP patients
with sepsis, providing a simple and low-cost predictive tool for clinical practice. It has significant
clinical value. I have several questions and hope to receive the author's answers:
1. For AP patients complicated by sepsis, is the source of infection secondary infection of
pancreatic necrotic tissue or infection of other organs outside the pancreas?
2. What is the statistical basis for grouping using the median RDW value?
3. It is well known that AP patients complicated by sepsis have already developed severe
complications such as IPN or organ failure. Can the proportion of patients with severe AP and
the number of surgical interventions in the two groups after grouping be described?
4. The author only used the first RDW test value after admission and did not analyze the
relationship between its dynamic changes and prognosis, such as the trend of RDW changes at
28 days, 90 days, and 365 days.
Please review this paper.
user
Title: Association of Red Blood Cell Distribution Width with Short- and Long-Term All-Cause
Mortality in Patients with Acute Pancreatitis and Sepsis
Version: 2 Date: 17 May 2025
Reviewer's report:
This study, through statistical analysis of patients with AP complicated by sepsis in the MIMIC-
IV database, revealed the potential value of RDW in the prognosis assessment of AP patients
with sepsis, providing a simple and low-cost predictive tool for clinical practice. It has significant
clinical value. I have several questions and hope to receive the author's answers:
1. For AP patients complicated by sepsis, is the source of infection secondary infection of
pancreatic necrotic tissue or infection of other organs outside the pancreas?
2. What is the statistical basis for grouping using the median RDW value?
3. It is well known that AP patients complicated by sepsis have already developed severe
complications such as IPN or organ failure. Can the proportion of patients with severe AP and
the number of surgical interventions in the two groups after grouping be described?
4. The author only used the first RDW test value after admission and did not analyze the
relationship between its dynamic changes and prognosis, such as the trend of RDW changes at
28 days, 90 days, and 365 days.
assistant