Reviewer's report
Title:Early effect of oral administration of omeprazole with mosapride as
compared with those of omeprazole alone on the intragastric pH
Version: 1Date:19 December 2011
Reviewer: Yoshihisa URITA
Reviewer's report:
Dear Dr. Hiroshi Iida,
Your manuscript entitled “Early effect of oral administration of omeprazole with
mosapride as compared with those of omeprazole alone on the intragastric pH.”
has been reviewed. The authors conclude that an oral dose of omeprazole 20 mg
plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole
20 mg alone. This manuscript is of enough interest and describes original work
that merits its publication in the journal of BMC Gastroenterol. Although the work
was of good quality, the manuscript required some revisions as below;
1. I cannot understand the mechanism by which administration of mosapride
enhances inhibitory effects of gastric acid secretion. Although the authors
described that mosapride accelerates the absorption of omeprazole, is this a true
theory? Furthermore, if enhanced gastric emptying is associated with enhanced
absorption from the small intestine, should administration of omeprazole plus
mosapride provide higher pH during earlier time? Contrary to this hypothesis, the
gastric pH was not higher during 0-1, 1-2, or 2-3-hour period, but significantly
higher during 3-5-hour study period in the present study. These results did not
accord with your description. The author should describe the mechanism of
inhibitory effect of gastric acid during ingestion of PPI plus mosapride.
2. In Figure 2, intragastric pH during 3-4-hour study period was fallen from 4.0 to
3.3. Why this transient decrease of intragastric pH observed in this study? Did
this reflect reduced blood concentration of omeprazole? If this speculation was
correct, why was the intragastric pH during 4-5-hour syudy period increased
again?
3. The big problem of the study was the absence of discussion on relationship
between enhanced absorption of omeprazole and unchanged pH in the early
time. Ordinary, enhanced absorption results in enhanced excretion, suggesting
that the effect of acid secretion should not be last for a long time. Why did
additional ingestion of mosapride avoid fall in intragastric pH during 3-4-hour
study period?
4. The authors should describe the kind of EIA kit used for H.pylori infection.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
declare that I have no competing interests
Reviewer's report
Title:Early effect of oral administration of omeprazole with mosapride as
compared with those of omeprazole alone on the intragastric pH
Version: 1Date:19 December 2011
Reviewer: Yoshihisa URITA
Reviewer's report:
Dear Dr. Hiroshi Iida,
Your manuscript entitled “Early effect of oral administration of omeprazole with
mosapride as compared with those of omeprazole alone on the intragastric pH.”
has been reviewed. The authors conclude that an oral dose of omeprazole 20 mg
plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole
20 mg alone. This manuscript is of enough interest and describes original work
that merits its publication in the journal of BMC Gastroenterol. Although the work
was of good quality, the manuscript required some revisions as below;
1. I cannot understand the mechanism by which administration of mosapride
enhances inhibitory effects of gastric acid secretion. Although the authors
described that mosapride accelerates the absorption of omeprazole, is this a true
theory? Furthermore, if enhanced gastric emptying is associated with enhanced
absorption from the small intestine, should administration of omeprazole plus
mosapride provide higher pH during earlier time? Contrary to this hypothesis, the
gastric pH was not higher during 0-1, 1-2, or 2-3-hour period, but significantly
higher during 3-5-hour study period in the present study. These results did not
accord with your description. The author should describe the mechanism of
inhibitory effect of gastric acid during ingestion of PPI plus mosapride.
2. In Figure 2, intragastric pH during 3-4-hour study period was fallen from 4.0 to
3.3. Why this transient decrease of intragastric pH observed in this study? Did
this reflect reduced blood concentration of omeprazole? If this speculation was
correct, why was the intragastric pH during 4-5-hour syudy period increased
again?
3. The big problem of the study was the absence of discussion on relationship
between enhanced absorption of omeprazole and unchanged pH in the early
time. Ordinary, enhanced absorption results in enhanced excretion, suggesting
that the effect of acid secretion should not be last for a long time. Why did
additional ingestion of mosapride avoid fall in intragastric pH during 3-4-hour
study period?
4. The authors should describe the kind of EIA kit used for H.pylori infection.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Early effect of oral administration of omeprazole with mosapride as
compared with those of omeprazole alone on the intragastric pH
Version: 1Date:19 December 2011
Reviewer: Yoshihisa URITA
Reviewer's report:
Dear Dr. Hiroshi Iida,
Your manuscript entitled “Early effect of oral administration of omeprazole with
mosapride as compared with those of omeprazole alone on the intragastric pH.”
has been reviewed. The authors conclude that an oral dose of omeprazole 20 mg
plus mosapride 5 mg increased the intragastric pH more rapidly than omeprazole
20 mg alone. This manuscript is of enough interest and describes original work
that merits its publication in the journal of BMC Gastroenterol. Although the work
was of good quality, the manuscript required some revisions as below;
1. I cannot understand the mechanism by which administration of mosapride
enhances inhibitory effects of gastric acid secretion. Although the authors
described that mosapride accelerates the absorption of omeprazole, is this a true
theory? Furthermore, if enhanced gastric emptying is associated with enhanced
absorption from the small intestine, should administration of omeprazole plus
mosapride provide higher pH during earlier time? Contrary to this hypothesis, the
gastric pH was not higher during 0-1, 1-2, or 2-3-hour period, but significantly
higher during 3-5-hour study period in the present study. These results did not
accord with your description. The author should describe the mechanism of
inhibitory effect of gastric acid during ingestion of PPI plus mosapride.
2. In Figure 2, intragastric pH during 3-4-hour study period was fallen from 4.0 to
3.3. Why this transient decrease of intragastric pH observed in this study? Did
this reflect reduced blood concentration of omeprazole? If this speculation was
correct, why was the intragastric pH during 4-5-hour syudy period increased
again?
3. The big problem of the study was the absence of discussion on relationship
between enhanced absorption of omeprazole and unchanged pH in the early
time. Ordinary, enhanced absorption results in enhanced excretion, suggesting
that the effect of acid secretion should not be last for a long time. Why did
additional ingestion of mosapride avoid fall in intragastric pH during 3-4-hour
study period?
4. The authors should describe the kind of EIA kit used for H.pylori infection.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
declare that I have no competing interests
assistant