Title: Multicenter analysis of the efficacy of early cholecystectomy and preoperative
cholecystostomy for severe acute cholecystitis: A retrospective study of data from the multi-
institutional database of the Hiroshima Surgical Study Group of Clinical Oncology
Version: 5 Date: 19 Aug 2024
Reviewer:  Samuele Vaccari
Reviewer's report:
Well-written and well-argued paper. The authors wanted to investigate the impact of pre-
operative percutaneous drainage in cases of grade III acute cholecystitis according to Tokyo18
Guidelines.
Despite the authors' limitations listed in the paper, we can get good information about this topic.
However, some points should be explored in depth for a better understanding of the study:
1. Were the patients undergoing percutaneous drainage operated on during the same
hospitalization? Specify the time between drainage placement and cholecystectomy.
2. Did the teams of surgeons use a common scheme, or did they decide based on their own
experience?
3. Please explain better when you performed the percutaneous drainage (characters of patients,
of disease, etcetera)
4. Perhaps it would be appropriate to specify the six mortality cases, highlighting the differences
or the things in common with the cases.
After these insights, we can consider the possibility of publishing the paper.
Title: Multicenter analysis of the efficacy of early cholecystectomy and preoperative
cholecystostomy for severe acute cholecystitis: A retrospective study of data from the multi-
institutional database of the Hiroshima Surgical Study Group of Clinical Oncology
Version: 5 Date: 19 Aug 2024
Reviewer:  Samuele Vaccari
Reviewer's report:
Well-written and well-argued paper. The authors wanted to investigate the impact of pre-
operative percutaneous drainage in cases of grade III acute cholecystitis according to Tokyo18
Guidelines.
Despite the authors' limitations listed in the paper, we can get good information about this topic.
However, some points should be explored in depth for a better understanding of the study:
1. Were the patients undergoing percutaneous drainage operated on during the same
hospitalization? Specify the time between drainage placement and cholecystectomy.
2. Did the teams of surgeons use a common scheme, or did they decide based on their own
experience?
3. Please explain better when you performed the percutaneous drainage (characters of patients,
of disease, etcetera)
4. Perhaps it would be appropriate to specify the six mortality cases, highlighting the differences
or the things in common with the cases.
After these insights, we can consider the possibility of publishing the paper.
Please review this paper.
user
Title: Multicenter analysis of the efficacy of early cholecystectomy and preoperative
cholecystostomy for severe acute cholecystitis: A retrospective study of data from the multi-
institutional database of the Hiroshima Surgical Study Group of Clinical Oncology
Version: 5 Date: 19 Aug 2024
Reviewer:  Samuele Vaccari
Reviewer's report:
Well-written and well-argued paper. The authors wanted to investigate the impact of pre-
operative percutaneous drainage in cases of grade III acute cholecystitis according to Tokyo18
Guidelines.
Despite the authors' limitations listed in the paper, we can get good information about this topic.
However, some points should be explored in depth for a better understanding of the study:
1. Were the patients undergoing percutaneous drainage operated on during the same
hospitalization? Specify the time between drainage placement and cholecystectomy.
2. Did the teams of surgeons use a common scheme, or did they decide based on their own
experience?
3. Please explain better when you performed the percutaneous drainage (characters of patients,
of disease, etcetera)
4. Perhaps it would be appropriate to specify the six mortality cases, highlighting the differences
or the things in common with the cases.
After these insights, we can consider the possibility of publishing the paper.
assistant