Title: Prognostic Role of Preoperative Inflammatory Markers in Postoperative Lung Metastasis
of Colorectal Cancer: A Retrospective Study
Version: 3 Date: 11 May 2025
Reviewer's report:
Thank you for the revised manuscript. I understand that your study aims to identify novel
prognostic factors that may help better stratify high-risk patients with pulmonary metastases.
If the purpose is to evaluate the predictive significance of inflammatory markers for lung-specific
metastasis, I believe it would be important to compare patients with pulmonary metastases to
those with other types of distant metastases. This would help clarify whether the identified
markers are specific to lung metastases or reflect a general metastatic tendency.
Additionally, could you clarify whether patients with pulmonary metastases who also had other
distant metastases were included or excluded from the analysis?
Including a detailed breakdown of metastatic patterns (e.g., lung only, liver only, peritoneum,
or multiple sites) in the table of baseline clinicopathological characteristics would also enhance
interpretability.
Title: Prognostic Role of Preoperative Inflammatory Markers in Postoperative Lung Metastasis
of Colorectal Cancer: A Retrospective Study
Version: 3 Date: 11 May 2025
Reviewer's report:
Thank you for the revised manuscript. I understand that your study aims to identify novel
prognostic factors that may help better stratify high-risk patients with pulmonary metastases.
If the purpose is to evaluate the predictive significance of inflammatory markers for lung-specific
metastasis, I believe it would be important to compare patients with pulmonary metastases to
those with other types of distant metastases. This would help clarify whether the identified
markers are specific to lung metastases or reflect a general metastatic tendency.
Additionally, could you clarify whether patients with pulmonary metastases who also had other
distant metastases were included or excluded from the analysis?
Including a detailed breakdown of metastatic patterns (e.g., lung only, liver only, peritoneum,
or multiple sites) in the table of baseline clinicopathological characteristics would also enhance
interpretability.
Please review this paper.
user
Title: Prognostic Role of Preoperative Inflammatory Markers in Postoperative Lung Metastasis
of Colorectal Cancer: A Retrospective Study
Version: 3 Date: 11 May 2025
Reviewer's report:
Thank you for the revised manuscript. I understand that your study aims to identify novel
prognostic factors that may help better stratify high-risk patients with pulmonary metastases.
If the purpose is to evaluate the predictive significance of inflammatory markers for lung-specific
metastasis, I believe it would be important to compare patients with pulmonary metastases to
those with other types of distant metastases. This would help clarify whether the identified
markers are specific to lung metastases or reflect a general metastatic tendency.
Additionally, could you clarify whether patients with pulmonary metastases who also had other
distant metastases were included or excluded from the analysis?
Including a detailed breakdown of metastatic patterns (e.g., lung only, liver only, peritoneum,
or multiple sites) in the table of baseline clinicopathological characteristics would also enhance
interpretability.
assistant