Title: HCV and HBV Genotypes: Vital in the Progression of HCV/ HBV Co-Infection
Version: 3 Date: 01 Oct 2024
Reviewer's report:
The study is designed to assess the impact of  the prevalence of HBV & HCV co infection and
the impact of the co infection amongst HCV impacted patients in Pakistan > it showed that 12%
of patients were coinfected with HBV. the co infection was more common in females than in
males  and females were at a higher risk of developing infection. The HCV infected patients
frequently developed co infection with HBV genotype D . The viral load comparison indicated
significant replicative dominance of HBV genotype D over HCV  1a , 2a and 3a genotypes  in
HBV-HCV coinfected patients . while the dominance of HCV genotype 3a on HBV genotype B.
The information generated highlights the importance of determining the genotypes in HCV and
HBV coinfection cases .
The authors need to highlight the importance of  the association of HBV genotype D with HCV
infection and they should point out whether HCC patients in Pakistan have a higher association
wit genotype D  as seen in India .
Title: HCV and HBV Genotypes: Vital in the Progression of HCV/ HBV Co-Infection
Version: 3 Date: 01 Oct 2024
Reviewer's report:
The study is designed to assess the impact of  the prevalence of HBV & HCV co infection and
the impact of the co infection amongst HCV impacted patients in Pakistan > it showed that 12%
of patients were coinfected with HBV. the co infection was more common in females than in
males  and females were at a higher risk of developing infection. The HCV infected patients
frequently developed co infection with HBV genotype D . The viral load comparison indicated
significant replicative dominance of HBV genotype D over HCV  1a , 2a and 3a genotypes  in
HBV-HCV coinfected patients . while the dominance of HCV genotype 3a on HBV genotype B.
The information generated highlights the importance of determining the genotypes in HCV and
HBV coinfection cases .
The authors need to highlight the importance of  the association of HBV genotype D with HCV
infection and they should point out whether HCC patients in Pakistan have a higher association
wit genotype D  as seen in India .
Please review this paper.
user
Title: HCV and HBV Genotypes: Vital in the Progression of HCV/ HBV Co-Infection
Version: 3 Date: 01 Oct 2024
Reviewer's report:
The study is designed to assess the impact of  the prevalence of HBV & HCV co infection and
the impact of the co infection amongst HCV impacted patients in Pakistan > it showed that 12%
of patients were coinfected with HBV. the co infection was more common in females than in
males  and females were at a higher risk of developing infection. The HCV infected patients
frequently developed co infection with HBV genotype D . The viral load comparison indicated
significant replicative dominance of HBV genotype D over HCV  1a , 2a and 3a genotypes  in
HBV-HCV coinfected patients . while the dominance of HCV genotype 3a on HBV genotype B.
The information generated highlights the importance of determining the genotypes in HCV and
HBV coinfection cases .
The authors need to highlight the importance of  the association of HBV genotype D with HCV
infection and they should point out whether HCC patients in Pakistan have a higher association
wit genotype D  as seen in India .
assistant