Title: Combination of tumor markers predicts progression and pathological response in patients
with locally advanced gastric cancer after neoadjuvant chemotherapy treatment
Version: 5 Date: 10 Mar 2021
Reviewer's report:
This paper described that tumor marker between neoadjuvant chemotherapy and operation could
predict progression free survival and pathological response in patients with locally advanced
gastric cancer. This study is very attractive to clinician and well written. But it does not reach
the accept level to this journal.
[Major points]
1. The meaning to investigate the prediction survival in preoperatively after chemotherapy is
still unclear. It is better that authors mention about residual tumor burden more.
2. Discussion is not sufficient. Biological mechanism for correlation between tumor marker and
long-term outcomes should be described.
Title: Combination of tumor markers predicts progression and pathological response in patients
with locally advanced gastric cancer after neoadjuvant chemotherapy treatment
Version: 5 Date: 10 Mar 2021
Reviewer's report:
This paper described that tumor marker between neoadjuvant chemotherapy and operation could
predict progression free survival and pathological response in patients with locally advanced
gastric cancer. This study is very attractive to clinician and well written. But it does not reach
the accept level to this journal.
[Major points]
1. The meaning to investigate the prediction survival in preoperatively after chemotherapy is
still unclear. It is better that authors mention about residual tumor burden more.
2. Discussion is not sufficient. Biological mechanism for correlation between tumor marker and
long-term outcomes should be described.
Please review this paper.
user
Title: Combination of tumor markers predicts progression and pathological response in patients
with locally advanced gastric cancer after neoadjuvant chemotherapy treatment
Version: 5 Date: 10 Mar 2021
Reviewer's report:
This paper described that tumor marker between neoadjuvant chemotherapy and operation could
predict progression free survival and pathological response in patients with locally advanced
gastric cancer. This study is very attractive to clinician and well written. But it does not reach
the accept level to this journal.
[Major points]
1. The meaning to investigate the prediction survival in preoperatively after chemotherapy is
still unclear. It is better that authors mention about residual tumor burden more.
2. Discussion is not sufficient. Biological mechanism for correlation between tumor marker and
long-term outcomes should be described.
assistant