Reviewer's report
Title:Dumping syndrome following Nissen fundoplication in an adult patient
diagnosed By BreathID continuous online 13C-octanoide acid breath test a case
report.
Version: 1Date:8 March 2010
Reviewer: Masaki Sanaka
Reviewer's report:
The 13C-octanoic acid breath test is currently in widespread use for
non-invasively evaluating gastric emptying of solid meals, although its utility in
clinical practices remains controversial. The present case report is valuable in
that it shows the clinical utility of the breath test. However, this article needs
extensive revision.
Major:
1. The Discussion section, in general, looks like a mini-review of the dumping
syndrome, and is therefore inappropriate. You should discuss how the breath test
is useful in diagnosis of the dumping syndrome. Do you think that the dumping
syndrome can be confirmed by the 13C breath test in patients with typical
symptoms even if an oral glucose challenge test is omitted?
2. You should describe the type of the test meal used and its caloric value,
because they highly affect the results of gastric emptying breath tests.
3. You should describe more in detail how you made a diagnosis of dumping
syndrome by the breath test. If you made the diagnosis based on the
conventional parameters (Tlag, T1/2, and GEC), you should present the
reference values of the parameters in your own institute. If you did based on the
shape of the breath PDR curve depicted in the Figure, you should clearly state
that the steep up-slope of the curve in the early postprandial phase represents
the initial rapid delivery of nutrients to the small intestine that would cause
dumping symptoms.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Dumping syndrome following Nissen fundoplication in an adult patient
diagnosed By BreathID continuous online 13C-octanoide acid breath test a case
report.
Version: 1Date:8 March 2010
Reviewer: Masaki Sanaka
Reviewer's report:
The 13C-octanoic acid breath test is currently in widespread use for
non-invasively evaluating gastric emptying of solid meals, although its utility in
clinical practices remains controversial. The present case report is valuable in
that it shows the clinical utility of the breath test. However, this article needs
extensive revision.
Major:
1. The Discussion section, in general, looks like a mini-review of the dumping
syndrome, and is therefore inappropriate. You should discuss how the breath test
is useful in diagnosis of the dumping syndrome. Do you think that the dumping
syndrome can be confirmed by the 13C breath test in patients with typical
symptoms even if an oral glucose challenge test is omitted?
2. You should describe the type of the test meal used and its caloric value,
because they highly affect the results of gastric emptying breath tests.
3. You should describe more in detail how you made a diagnosis of dumping
syndrome by the breath test. If you made the diagnosis based on the
conventional parameters (Tlag, T1/2, and GEC), you should present the
reference values of the parameters in your own institute. If you did based on the
shape of the breath PDR curve depicted in the Figure, you should clearly state
that the steep up-slope of the curve in the early postprandial phase represents
the initial rapid delivery of nutrients to the small intestine that would cause
dumping symptoms.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Dumping syndrome following Nissen fundoplication in an adult patient
diagnosed By BreathID continuous online 13C-octanoide acid breath test a case
report.
Version: 1Date:8 March 2010
Reviewer: Masaki Sanaka
Reviewer's report:
The 13C-octanoic acid breath test is currently in widespread use for
non-invasively evaluating gastric emptying of solid meals, although its utility in
clinical practices remains controversial. The present case report is valuable in
that it shows the clinical utility of the breath test. However, this article needs
extensive revision.
Major:
1. The Discussion section, in general, looks like a mini-review of the dumping
syndrome, and is therefore inappropriate. You should discuss how the breath test
is useful in diagnosis of the dumping syndrome. Do you think that the dumping
syndrome can be confirmed by the 13C breath test in patients with typical
symptoms even if an oral glucose challenge test is omitted?
2. You should describe the type of the test meal used and its caloric value,
because they highly affect the results of gastric emptying breath tests.
3. You should describe more in detail how you made a diagnosis of dumping
syndrome by the breath test. If you made the diagnosis based on the
conventional parameters (Tlag, T1/2, and GEC), you should present the
reference values of the parameters in your own institute. If you did based on the
shape of the breath PDR curve depicted in the Figure, you should clearly state
that the steep up-slope of the curve in the early postprandial phase represents
the initial rapid delivery of nutrients to the small intestine that would cause
dumping symptoms.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant