Title: Prognostic factors of pancreatic tumors in children and adolescents: A population study
based on the Surveillance, Epidemiology, and End Results Database
Version: 7 Date: 27 Jan 2024
Reviewer's report:
Significance and Originality: The manuscript provides valuable insights into the epidemiology
and prognosis of pediatric pancreatic tumors, a notably understudied area in oncology. By
leveraging a large, population-based database, the study addresses a critical gap in the literature.
However, it would be beneficial to further highlight the unique contributions of this research
in the context of existing literature. The discussion section could be enhanced by comparing
and contrasting these findings with previous studies, particularly those that may have reported
contrasting results or insights. This comparison would not only reinforce the significance of the
current study but also provide a more comprehensive understanding of the state of research in
this field.
Methodological Rigor: The methodology, including patient selection and statistical analysis,
appears well-structured and appropriate for the study objectives. Nonetheless, there are a
few areas that could be improved for greater clarity and robustness. Firstly, a more detailed
explanation of the criteria for patient inclusion and exclusion would strengthen the study's
validity. Secondly, while the use of the SEER database is a strength, acknowledging its
limitations more thoroughly in the discussion would enhance the manuscript's credibility. This
includes potential biases and the generalizability of the findings. Lastly, the authors might
consider discussing the rationale behind the choice of statistical tests and the implications of
these choices for their findings.
Clinical Implications and Future Directions: The study's findings have significant implications
for the clinical management of pediatric pancreatic tumors, particularly emphasizing the role
of surgical intervention. It would be beneficial for the authors to more explicitly discuss these
implications, perhaps offering specific recommendations for clinical practice or guidelines based
on their findings. Additionally, the study opens avenues for future research, such as investigating
the biological mechanisms underlying the observed differences in survival rates between genders
and tumor types. Addressing these aspects would not only enhance the applicability of the study
but also guide future research efforts in this field.
In summary, while the study provides important contributions to our understanding of pediatric
pancreatic tumors, enhancing the discussion around its context in the broader literature,
clarifying methodological details, and expanding on its clinical implications would further
strengthen the manuscript.
Title: Prognostic factors of pancreatic tumors in children and adolescents: A population study
based on the Surveillance, Epidemiology, and End Results Database
Version: 7 Date: 27 Jan 2024
Reviewer's report:
Significance and Originality: The manuscript provides valuable insights into the epidemiology
and prognosis of pediatric pancreatic tumors, a notably understudied area in oncology. By
leveraging a large, population-based database, the study addresses a critical gap in the literature.
However, it would be beneficial to further highlight the unique contributions of this research
in the context of existing literature. The discussion section could be enhanced by comparing
and contrasting these findings with previous studies, particularly those that may have reported
contrasting results or insights. This comparison would not only reinforce the significance of the
current study but also provide a more comprehensive understanding of the state of research in
this field.
Methodological Rigor: The methodology, including patient selection and statistical analysis,
appears well-structured and appropriate for the study objectives. Nonetheless, there are a
few areas that could be improved for greater clarity and robustness. Firstly, a more detailed
explanation of the criteria for patient inclusion and exclusion would strengthen the study's
validity. Secondly, while the use of the SEER database is a strength, acknowledging its
limitations more thoroughly in the discussion would enhance the manuscript's credibility. This
includes potential biases and the generalizability of the findings. Lastly, the authors might
consider discussing the rationale behind the choice of statistical tests and the implications of
these choices for their findings.
Clinical Implications and Future Directions: The study's findings have significant implications
for the clinical management of pediatric pancreatic tumors, particularly emphasizing the role
of surgical intervention. It would be beneficial for the authors to more explicitly discuss these
implications, perhaps offering specific recommendations for clinical practice or guidelines based
on their findings. Additionally, the study opens avenues for future research, such as investigating
the biological mechanisms underlying the observed differences in survival rates between genders
and tumor types. Addressing these aspects would not only enhance the applicability of the study
but also guide future research efforts in this field.
In summary, while the study provides important contributions to our understanding of pediatric
pancreatic tumors, enhancing the discussion around its context in the broader literature,
clarifying methodological details, and expanding on its clinical implications would further
strengthen the manuscript.
Please review this paper.
user
Title: Prognostic factors of pancreatic tumors in children and adolescents: A population study
based on the Surveillance, Epidemiology, and End Results Database
Version: 7 Date: 27 Jan 2024
Reviewer's report:
Significance and Originality: The manuscript provides valuable insights into the epidemiology
and prognosis of pediatric pancreatic tumors, a notably understudied area in oncology. By
leveraging a large, population-based database, the study addresses a critical gap in the literature.
However, it would be beneficial to further highlight the unique contributions of this research
in the context of existing literature. The discussion section could be enhanced by comparing
and contrasting these findings with previous studies, particularly those that may have reported
contrasting results or insights. This comparison would not only reinforce the significance of the
current study but also provide a more comprehensive understanding of the state of research in
this field.
Methodological Rigor: The methodology, including patient selection and statistical analysis,
appears well-structured and appropriate for the study objectives. Nonetheless, there are a
few areas that could be improved for greater clarity and robustness. Firstly, a more detailed
explanation of the criteria for patient inclusion and exclusion would strengthen the study's
validity. Secondly, while the use of the SEER database is a strength, acknowledging its
limitations more thoroughly in the discussion would enhance the manuscript's credibility. This
includes potential biases and the generalizability of the findings. Lastly, the authors might
consider discussing the rationale behind the choice of statistical tests and the implications of
these choices for their findings.
Clinical Implications and Future Directions: The study's findings have significant implications
for the clinical management of pediatric pancreatic tumors, particularly emphasizing the role
of surgical intervention. It would be beneficial for the authors to more explicitly discuss these
implications, perhaps offering specific recommendations for clinical practice or guidelines based
on their findings. Additionally, the study opens avenues for future research, such as investigating
the biological mechanisms underlying the observed differences in survival rates between genders
and tumor types. Addressing these aspects would not only enhance the applicability of the study
but also guide future research efforts in this field.
In summary, while the study provides important contributions to our understanding of pediatric
pancreatic tumors, enhancing the discussion around its context in the broader literature,
clarifying methodological details, and expanding on its clinical implications would further
strengthen the manuscript.
assistant