Reviewer's report
Title:Intestinal permeability - a new target for disease prevention and therapy?
Version:3Date:5 May 2014
Reviewer: Alexandra Zhernakova
Reviewer's report:
Bischoff and co-authors present a complete and well-written review on intestinal
permeability. It provides a good overview of all permeability aspects as well as
mechanistic insight and future perspectives.
I only have minor comments:
1. CD and UC should be written in full when used the first time. Same for other
abbreviation.
2. “Paneth cells produce a range of antimicrobial factors to protect the crypt cells
from infection with microorganisms including alpha--#defensins, lysozyme and
Reg3 proteins corresponding to HIP/PAP in humans” – since the paper is about
human intestinal barrier, it is better to name human protein and then their mouse
homolog.
3. Gene names should be written in italic.
4. Mutagenomic (page 10) should be Metagenomic
5. It would be useful to add a few sentences on the link of gut bacterial richness
and diseases.
6. It is surprising not to see celiac disease among the list of diseases linked with
impaired intestinal permeability. There are several studies published on
permeability in celiac disease.
7. Table 4: why is biomarker mentioned in the “disadvantage” column?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Intestinal permeability - a new target for disease prevention and therapy?
Version:3Date:5 May 2014
Reviewer: Alexandra Zhernakova
Reviewer's report:
Bischoff and co-authors present a complete and well-written review on intestinal
permeability. It provides a good overview of all permeability aspects as well as
mechanistic insight and future perspectives.
I only have minor comments:
1. CD and UC should be written in full when used the first time. Same for other
abbreviation.
2. “Paneth cells produce a range of antimicrobial factors to protect the crypt cells
from infection with microorganisms including alpha--#defensins, lysozyme and
Reg3 proteins corresponding to HIP/PAP in humans” – since the paper is about
human intestinal barrier, it is better to name human protein and then their mouse
homolog.
3. Gene names should be written in italic.
4. Mutagenomic (page 10) should be Metagenomic
5. It would be useful to add a few sentences on the link of gut bacterial richness
and diseases.
6. It is surprising not to see celiac disease among the list of diseases linked with
impaired intestinal permeability. There are several studies published on
permeability in celiac disease.
7. Table 4: why is biomarker mentioned in the “disadvantage” column?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
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Reviewer's report
Title:Intestinal permeability - a new target for disease prevention and therapy?
Version:3Date:5 May 2014
Reviewer: Alexandra Zhernakova
Reviewer's report:
Bischoff and co-authors present a complete and well-written review on intestinal
permeability. It provides a good overview of all permeability aspects as well as
mechanistic insight and future perspectives.
I only have minor comments:
1. CD and UC should be written in full when used the first time. Same for other
abbreviation.
2. “Paneth cells produce a range of antimicrobial factors to protect the crypt cells
from infection with microorganisms including alpha--#defensins, lysozyme and
Reg3 proteins corresponding to HIP/PAP in humans” – since the paper is about
human intestinal barrier, it is better to name human protein and then their mouse
homolog.
3. Gene names should be written in italic.
4. Mutagenomic (page 10) should be Metagenomic
5. It would be useful to add a few sentences on the link of gut bacterial richness
and diseases.
6. It is surprising not to see celiac disease among the list of diseases linked with
impaired intestinal permeability. There are several studies published on
permeability in celiac disease.
7. Table 4: why is biomarker mentioned in the “disadvantage” column?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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