Reviewer's report
Title:Symptoms and signs in latent celiac disease - a validation study
Version: 1Date:5 May 2009
Reviewer: Vincenzo Villanacci
Reviewer's report:
The paper is well written with useful notices in the field of diagnosis and
treatment of coeliac disease. I suggest to accept the paper.
I ask to the authors only a specification about the number of intraepithelial
lymphocytes because at moment the normal value is 25-30 IEL for 100 epithelial
cells and in the classification of Marsh-Oberhuber was used the value 0f 40/100
epithelial cells. It is important in the text of the paper this specification.In the
bibliography I suggest to enclose two papers on the argument.
Hayat M, Cairns A, Dixon MF, O'Mahony S.
Quantitation of intraepithelial lymphocytes in human duodenum: what is normal?
J Clin Pathol. 2002 May;55(5):393-4.
Veress B, Franzen L, Bodin L, Borch K.
Duodenal Intraepithelial Lymphocyte Count Revisited
Scand J Gastroenterol 2004 Feb;39(2):138-44.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Symptoms and signs in latent celiac disease - a validation study
Version: 1Date:5 May 2009
Reviewer: Vincenzo Villanacci
Reviewer's report:
The paper is well written with useful notices in the field of diagnosis and
treatment of coeliac disease. I suggest to accept the paper.
I ask to the authors only a specification about the number of intraepithelial
lymphocytes because at moment the normal value is 25-30 IEL for 100 epithelial
cells and in the classification of Marsh-Oberhuber was used the value 0f 40/100
epithelial cells. It is important in the text of the paper this specification.In the
bibliography I suggest to enclose two papers on the argument.
Hayat M, Cairns A, Dixon MF, O'Mahony S.
Quantitation of intraepithelial lymphocytes in human duodenum: what is normal?
J Clin Pathol. 2002 May;55(5):393-4.
Veress B, Franzen L, Bodin L, Borch K.
Duodenal Intraepithelial Lymphocyte Count Revisited
Scand J Gastroenterol 2004 Feb;39(2):138-44.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Symptoms and signs in latent celiac disease - a validation study
Version: 1Date:5 May 2009
Reviewer: Vincenzo Villanacci
Reviewer's report:
The paper is well written with useful notices in the field of diagnosis and
treatment of coeliac disease. I suggest to accept the paper.
I ask to the authors only a specification about the number of intraepithelial
lymphocytes because at moment the normal value is 25-30 IEL for 100 epithelial
cells and in the classification of Marsh-Oberhuber was used the value 0f 40/100
epithelial cells. It is important in the text of the paper this specification.In the
bibliography I suggest to enclose two papers on the argument.
Hayat M, Cairns A, Dixon MF, O'Mahony S.
Quantitation of intraepithelial lymphocytes in human duodenum: what is normal?
J Clin Pathol. 2002 May;55(5):393-4.
Veress B, Franzen L, Bodin L, Borch K.
Duodenal Intraepithelial Lymphocyte Count Revisited
Scand J Gastroenterol 2004 Feb;39(2):138-44.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant