Title: RECENT ADVANCES IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS
Version: 3 Date: 19 Oct 2021
Reviewer:  Guofang Deng
Reviewer's report:
The review examined the advance in the field of diagnosis of intestinal tuberculosis. The subject
is interesting .The title and abstract cover the main aspect of work and the flow is quite clear.
But as a review about the diagnosis of ITB. The most difficult thing is to distinguish intestinal
tuberculosis (ITB) from Crohn's disease (CD). A positive interferon-# release assay could give
us a clue to look for TB evidence, especially in a low-Tb setting. I suppose that this part about
IGRAs should be included in the manuscript. Some important citations were missing in the
review. Like:
1. Limsrivilai J, Shreiner AB, Pongpaibul A, Laohapand C, Boonanuwat R, Pausawasdi
N, Pongprasobchai S, Manatsathit S, Higgins PD. Meta-Analytic Bayesian Model For
Differentiating Intestinal Tuberculosis from Crohn's Disease. Am J Gastroenterol. 2017
Mar;112(3):415-427. doi: 10.1038/ajg.2016.529. Epub 2017 Jan 3. PMID: 28045023; PMCID:
PMC5551982.
2. Ng SC, Hirai HW, Tsoi KK, Wong SH, Chan FK, Sung JJ, Wu JC. Systematic review
with meta-analysis: accuracy of interferon-gamma releasing assay and anti-Saccharomyces
cerevisiae antibody in differentiating intestinal tuberculosis from Crohn's disease in Asians. J
Gastroenterol Hepatol. 2014 Sep;29(9):1664-70. doi: 10.1111/jgh.12645. PMID: 24910240.
On the other hand, it had been demonstrated that GeneXpert Ultra is more sensitive than
GeneXpert MTB/RIF in detecting TB even in extrapulmonary specimens. Do authors have any
evidence to support it in the diagnosis of ITB?  Please search for more citations to enrich this
part.  And the sentence described that” where sensitivity can reach 100% by using specimens
such as sputum or bronchoalveolar lavage” is not right. The pooled sensitivity of Xpert should
be corrected according to the reference.
Title: RECENT ADVANCES IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS
Version: 3 Date: 19 Oct 2021
Reviewer:  Guofang Deng
Reviewer's report:
The review examined the advance in the field of diagnosis of intestinal tuberculosis. The subject
is interesting .The title and abstract cover the main aspect of work and the flow is quite clear.
But as a review about the diagnosis of ITB. The most difficult thing is to distinguish intestinal
tuberculosis (ITB) from Crohn's disease (CD). A positive interferon-# release assay could give
us a clue to look for TB evidence, especially in a low-Tb setting. I suppose that this part about
IGRAs should be included in the manuscript. Some important citations were missing in the
review. Like:
1. Limsrivilai J, Shreiner AB, Pongpaibul A, Laohapand C, Boonanuwat R, Pausawasdi
N, Pongprasobchai S, Manatsathit S, Higgins PD. Meta-Analytic Bayesian Model For
Differentiating Intestinal Tuberculosis from Crohn's Disease. Am J Gastroenterol. 2017
Mar;112(3):415-427. doi: 10.1038/ajg.2016.529. Epub 2017 Jan 3. PMID: 28045023; PMCID:
PMC5551982.
2. Ng SC, Hirai HW, Tsoi KK, Wong SH, Chan FK, Sung JJ, Wu JC. Systematic review
with meta-analysis: accuracy of interferon-gamma releasing assay and anti-Saccharomyces
cerevisiae antibody in differentiating intestinal tuberculosis from Crohn's disease in Asians. J
Gastroenterol Hepatol. 2014 Sep;29(9):1664-70. doi: 10.1111/jgh.12645. PMID: 24910240.
On the other hand, it had been demonstrated that GeneXpert Ultra is more sensitive than
GeneXpert MTB/RIF in detecting TB even in extrapulmonary specimens. Do authors have any
evidence to support it in the diagnosis of ITB?  Please search for more citations to enrich this
part.  And the sentence described that” where sensitivity can reach 100% by using specimens
such as sputum or bronchoalveolar lavage” is not right. The pooled sensitivity of Xpert should
be corrected according to the reference.
Please review this paper.
user
Title: RECENT ADVANCES IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS
Version: 3 Date: 19 Oct 2021
Reviewer:  Guofang Deng
Reviewer's report:
The review examined the advance in the field of diagnosis of intestinal tuberculosis. The subject
is interesting .The title and abstract cover the main aspect of work and the flow is quite clear.
But as a review about the diagnosis of ITB. The most difficult thing is to distinguish intestinal
tuberculosis (ITB) from Crohn's disease (CD). A positive interferon-# release assay could give
us a clue to look for TB evidence, especially in a low-Tb setting. I suppose that this part about
IGRAs should be included in the manuscript. Some important citations were missing in the
review. Like:
1. Limsrivilai J, Shreiner AB, Pongpaibul A, Laohapand C, Boonanuwat R, Pausawasdi
N, Pongprasobchai S, Manatsathit S, Higgins PD. Meta-Analytic Bayesian Model For
Differentiating Intestinal Tuberculosis from Crohn's Disease. Am J Gastroenterol. 2017
Mar;112(3):415-427. doi: 10.1038/ajg.2016.529. Epub 2017 Jan 3. PMID: 28045023; PMCID:
PMC5551982.
2. Ng SC, Hirai HW, Tsoi KK, Wong SH, Chan FK, Sung JJ, Wu JC. Systematic review
with meta-analysis: accuracy of interferon-gamma releasing assay and anti-Saccharomyces
cerevisiae antibody in differentiating intestinal tuberculosis from Crohn's disease in Asians. J
Gastroenterol Hepatol. 2014 Sep;29(9):1664-70. doi: 10.1111/jgh.12645. PMID: 24910240.
On the other hand, it had been demonstrated that GeneXpert Ultra is more sensitive than
GeneXpert MTB/RIF in detecting TB even in extrapulmonary specimens. Do authors have any
evidence to support it in the diagnosis of ITB?  Please search for more citations to enrich this
part.  And the sentence described that” where sensitivity can reach 100% by using specimens
such as sputum or bronchoalveolar lavage” is not right. The pooled sensitivity of Xpert should
be corrected according to the reference.
assistant