Title: Global burden, trends, and risk factors of early-onset and late-onset colorectal cancer from
1990 to 2021, with projections to 2040: A population-based study
Version: 0 Date: 28 Mar 2025
Reviewer:  Zelalem Asefa
Reviewer's report:
Global burden, trends, and risk factors of early-onset and late-onset colorectal cancer from 1990
to 2021, with projections to 2040: A population-based study
Comments:
1. General comment: The study was conducted to compare the global burden of early onset
colorectal cancer (EOCRC) with late onset colorectal cancer (LOCRC). The authors also tried
to assess the association of national development status, risk factors and the future burden of
EOCRC and LOCRC. The study seems the first of its kind to answer research questions with
those respects.
- The results were accurately reported except for minor corrections as suggested below in the
specific comments.
-The authors documented the limitations of their study and the conclusions and the
recommendations suggested are according to their study results.
2. Specific comments on the manuscript: The specific comments were given referring to the
topic in the text and mentioning the line at which correction has to be considered.
2. Methods
2.1 Data Resource
It is better to change Data Resource to Data Sources
2.2  Definition of EOCRC/LOCRC
-2.3 Definition of Sociodemographic Index
Line 2: SDI which was written after full stop is better written in extended form as The
Sociodemographic Index values range…
2.5 Statistical Analysis
- Line 4: AAPCs which was written after full stop is better written in extended form as Average
annual percentage changes…
3. Results
3.1 Global Burden of EOCRC and LOCRC
- Line 4: It is good to put Table 1 in parenthesis as (Table 1). The same suggestions for Table
S1, Table S2 and Table S3
- The headings of the tables are better placed at the top of the table
Sincerely Yours,
Dr Zelalem Asefa
General and Colorectal Surgeon
Addis Ababa University
College of Health Sciences
Title: Global burden, trends, and risk factors of early-onset and late-onset colorectal cancer from
1990 to 2021, with projections to 2040: A population-based study
Version: 0 Date: 28 Mar 2025
Reviewer:  Zelalem Asefa
Reviewer's report:
Global burden, trends, and risk factors of early-onset and late-onset colorectal cancer from 1990
to 2021, with projections to 2040: A population-based study
Comments:
1. General comment: The study was conducted to compare the global burden of early onset
colorectal cancer (EOCRC) with late onset colorectal cancer (LOCRC). The authors also tried
to assess the association of national development status, risk factors and the future burden of
EOCRC and LOCRC. The study seems the first of its kind to answer research questions with
those respects.
- The results were accurately reported except for minor corrections as suggested below in the
specific comments.
-The authors documented the limitations of their study and the conclusions and the
recommendations suggested are according to their study results.
2. Specific comments on the manuscript: The specific comments were given referring to the
topic in the text and mentioning the line at which correction has to be considered.
2. Methods
2.1 Data Resource
It is better to change Data Resource to Data Sources
2.2  Definition of EOCRC/LOCRC
-2.3 Definition of Sociodemographic Index
Line 2: SDI which was written after full stop is better written in extended form as The
Sociodemographic Index values range…
2.5 Statistical Analysis
- Line 4: AAPCs which was written after full stop is better written in extended form as Average
annual percentage changes…
3. Results
3.1 Global Burden of EOCRC and LOCRC
- Line 4: It is good to put Table 1 in parenthesis as (Table 1). The same suggestions for Table
S1, Table S2 and Table S3
- The headings of the tables are better placed at the top of the table
Sincerely Yours,
Dr Zelalem Asefa
General and Colorectal Surgeon
Addis Ababa University
College of Health Sciences
Please review this paper.
user
Title: Global burden, trends, and risk factors of early-onset and late-onset colorectal cancer from
1990 to 2021, with projections to 2040: A population-based study
Version: 0 Date: 28 Mar 2025
Reviewer:  Zelalem Asefa
Reviewer's report:
Global burden, trends, and risk factors of early-onset and late-onset colorectal cancer from 1990
to 2021, with projections to 2040: A population-based study
Comments:
1. General comment: The study was conducted to compare the global burden of early onset
colorectal cancer (EOCRC) with late onset colorectal cancer (LOCRC). The authors also tried
to assess the association of national development status, risk factors and the future burden of
EOCRC and LOCRC. The study seems the first of its kind to answer research questions with
those respects.
- The results were accurately reported except for minor corrections as suggested below in the
specific comments.
-The authors documented the limitations of their study and the conclusions and the
recommendations suggested are according to their study results.
2. Specific comments on the manuscript: The specific comments were given referring to the
topic in the text and mentioning the line at which correction has to be considered.
2. Methods
2.1 Data Resource
It is better to change Data Resource to Data Sources
2.2  Definition of EOCRC/LOCRC
-2.3 Definition of Sociodemographic Index
Line 2: SDI which was written after full stop is better written in extended form as The
Sociodemographic Index values range…
2.5 Statistical Analysis
- Line 4: AAPCs which was written after full stop is better written in extended form as Average
annual percentage changes…
3. Results
3.1 Global Burden of EOCRC and LOCRC
- Line 4: It is good to put Table 1 in parenthesis as (Table 1). The same suggestions for Table
S1, Table S2 and Table S3
- The headings of the tables are better placed at the top of the table
Sincerely Yours,
Dr Zelalem Asefa
General and Colorectal Surgeon
Addis Ababa University
College of Health Sciences
assistant