Reviewer ’s report  
 
Title: A rare case of Epstein –Barr virus -positive mucocutaneo us ulcer that developed into an 
intestinal obstruction  
 
Version: 0 Date: 19 May 2019  
 
Reviewer: Hongbo Wei  
 
Reviewer's report:  
 
1.The authors reported a rare case of EBV -MCU manifested as a big mass in the transverse colon 
that finally developed into intestinal obstruction. This case added novel informatio n to the field 
that EBV -EBU can cause ileus even in its period of regression, and needed to be surgically 
resected.  
 
2.I doubt the decision not to perform a laparotomy when first -time CT scan and colonoscopy 
discovered a tumorous lesion in the transverse co lon which had already caused luminal stenosis. 
I think the authors should discuss this in the paper.  
 
3.The manuscript requires a thorough revision of the grammar and structure by a native English 
speaker.  
 
4.Laboratory finding did not need to be repeated in  the text and in the table.  
 
5.I suggest the authors to combine all the three CT images into a big figure arranged in 
chronological order.  
 
6.Overall, I would like to afford the authors a chance for a major revision.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are requir ed in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommen d an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the q uality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: A rare case of Epstein –Barr virus -positive mucocutaneo us ulcer that developed into an 
intestinal obstruction  
 
Version: 0 Date: 19 May 2019  
 
Reviewer: Hongbo Wei  
 
Reviewer's report:  
 
1.The authors reported a rare case of EBV -MCU manifested as a big mass in the transverse colon 
that finally developed into intestinal obstruction. This case added novel informatio n to the field 
that EBV -EBU can cause ileus even in its period of regression, and needed to be surgically 
resected.  
 
2.I doubt the decision not to perform a laparotomy when first -time CT scan and colonoscopy 
discovered a tumorous lesion in the transverse co lon which had already caused luminal stenosis. 
I think the authors should discuss this in the paper.  
 
3.The manuscript requires a thorough revision of the grammar and structure by a native English 
speaker.  
 
4.Laboratory finding did not need to be repeated in  the text and in the table.  
 
5.I suggest the authors to combine all the three CT images into a big figure arranged in 
chronological order.  
 
6.Overall, I would like to afford the authors a chance for a major revision.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are requir ed in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommen d an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the q uality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: A rare case of Epstein –Barr virus -positive mucocutaneo us ulcer that developed into an 
intestinal obstruction  
 
Version: 0 Date: 19 May 2019  
 
Reviewer: Hongbo Wei  
 
Reviewer's report:  
 
1.The authors reported a rare case of EBV -MCU manifested as a big mass in the transverse colon 
that finally developed into intestinal obstruction. This case added novel informatio n to the field 
that EBV -EBU can cause ileus even in its period of regression, and needed to be surgically 
resected.  
 
2.I doubt the decision not to perform a laparotomy when first -time CT scan and colonoscopy 
discovered a tumorous lesion in the transverse co lon which had already caused luminal stenosis. 
I think the authors should discuss this in the paper.  
 
3.The manuscript requires a thorough revision of the grammar and structure by a native English 
speaker.  
 
4.Laboratory finding did not need to be repeated in  the text and in the table.  
 
5.I suggest the authors to combine all the three CT images into a big figure arranged in 
chronological order.  
 
6.Overall, I would like to afford the authors a chance for a major revision.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are requir ed in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommen d an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the q uality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant