Reviewer's report
Title:Gender aspects suggestive of gastroparesis in patients with diabetes
mellitus: A cross-sectional survey
Version: 3Date:1 October 2013
Reviewer: PANDU GANGULA
Reviewer's report:
Overall, the findings from this manuscript is supporting the existing reports that
gastroparesis rate is higher in women than men in the onset of diabetes.
Furthermore, this study pointed (speculated most of the time based on other
reports) out that estrogen (again speculations) may not be the only factor that
draws the boundary between male and female for gastroparesis. This was based
upon the mean age that is elderly patients (above 60 yr old) in which estrogen
levels are supposed to be lower. However, again this study was unable to
document if these patients are taking HRT or not. Furthermore, authors
speculated that obese patients may have higher estrogen levels as opposed to
lower levels due to adipose tissue secretes more estrogen.
In my opinion, rather speculate the very interesting findings with other published
papers, it is recommended to analyze certain biomarkers namely estrogens and
others as published by other groups and correlate the observed findings in detail.
Furthermore, it is suggested to get HRT report for these patients and report in the
revision. However, authors needs to be careful while reporting HRTdata because
HRT could be either beneficial or detrimental depend on type of HRT used, dose,
timing and route of HRT taken by the each patient.
Authors have used 'suggestive' in many places starting from the title and abstract
(5 times in the abstract). I think this needs to be revised.
Also it is not clear from the report that if age has anything to do with the severity
of the gastroparesis observed in men vs. women. This needs to be clarified.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Gender aspects suggestive of gastroparesis in patients with diabetes
mellitus: A cross-sectional survey
Version: 3Date:1 October 2013
Reviewer: PANDU GANGULA
Reviewer's report:
Overall, the findings from this manuscript is supporting the existing reports that
gastroparesis rate is higher in women than men in the onset of diabetes.
Furthermore, this study pointed (speculated most of the time based on other
reports) out that estrogen (again speculations) may not be the only factor that
draws the boundary between male and female for gastroparesis. This was based
upon the mean age that is elderly patients (above 60 yr old) in which estrogen
levels are supposed to be lower. However, again this study was unable to
document if these patients are taking HRT or not. Furthermore, authors
speculated that obese patients may have higher estrogen levels as opposed to
lower levels due to adipose tissue secretes more estrogen.
In my opinion, rather speculate the very interesting findings with other published
papers, it is recommended to analyze certain biomarkers namely estrogens and
others as published by other groups and correlate the observed findings in detail.
Furthermore, it is suggested to get HRT report for these patients and report in the
revision. However, authors needs to be careful while reporting HRTdata because
HRT could be either beneficial or detrimental depend on type of HRT used, dose,
timing and route of HRT taken by the each patient.
Authors have used 'suggestive' in many places starting from the title and abstract
(5 times in the abstract). I think this needs to be revised.
Also it is not clear from the report that if age has anything to do with the severity
of the gastroparesis observed in men vs. women. This needs to be clarified.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Gender aspects suggestive of gastroparesis in patients with diabetes
mellitus: A cross-sectional survey
Version: 3Date:1 October 2013
Reviewer: PANDU GANGULA
Reviewer's report:
Overall, the findings from this manuscript is supporting the existing reports that
gastroparesis rate is higher in women than men in the onset of diabetes.
Furthermore, this study pointed (speculated most of the time based on other
reports) out that estrogen (again speculations) may not be the only factor that
draws the boundary between male and female for gastroparesis. This was based
upon the mean age that is elderly patients (above 60 yr old) in which estrogen
levels are supposed to be lower. However, again this study was unable to
document if these patients are taking HRT or not. Furthermore, authors
speculated that obese patients may have higher estrogen levels as opposed to
lower levels due to adipose tissue secretes more estrogen.
In my opinion, rather speculate the very interesting findings with other published
papers, it is recommended to analyze certain biomarkers namely estrogens and
others as published by other groups and correlate the observed findings in detail.
Furthermore, it is suggested to get HRT report for these patients and report in the
revision. However, authors needs to be careful while reporting HRTdata because
HRT could be either beneficial or detrimental depend on type of HRT used, dose,
timing and route of HRT taken by the each patient.
Authors have used 'suggestive' in many places starting from the title and abstract
(5 times in the abstract). I think this needs to be revised.
Also it is not clear from the report that if age has anything to do with the severity
of the gastroparesis observed in men vs. women. This needs to be clarified.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant