Reviewer's report
Title:Inflammatory bowel disease (IBD)-like disease in a case of a 33-year old
man with glycogenosis 1b
Version:2Date:13 February 2015
Reviewer: Shanthi Palaniappan
Reviewer's report:
Overall the case report is interesting and this is probably the oldest patient with
glycogenosis presenting with IBD like disease reported . On most parts it is well
written - some corrections as given below.
Minor Essential Revisions:
1. The Back ground and Case presentation should be clearly separated and not
merged together. Also, there should be a heading with discussion and a small
paragraph on conclusion ( now the whole discussion and conclusion is merged
together)
2. In the background the average age at presentation of IBD like disease should
be mentioned and therefore emphasis should be made that this case reports an
older patient
3. Case Presentation - history needs to be a bit more detailed particularly
mentioning the duration of symptoms, any family history of IBD , clinical
examination findings (any evidence of perioral disease / perianal disease etc and
general examination - growth retardation, hepatosplenomagly etc
4. what was the neutrophil count? ( only leukopenia mentioned). Inflammatory
markers on presentation - ESR / CRP?
5. Discussion - should emphasise the older age and possible causes why there
was a delayed presentation in age ( is it because this patients has been on
continuous GCSF and therefore neutrophil count has been maintained higher ? )
6. For Figures - Imaging and endoscopy mixed up
suggest 1A / 1B - CT, 1C - US bowel, 1D/ E - endoscopy, 1F - histology
7. Line 104-107 - grammar correction
Discretionary Revisions:
1. Discussion - other theories postulated on the causes of IBD like disease in
glycogenosis ( and not just chronic infection of gut due to neutropenia)
2. Line 45 - protein level - there is a ? in the brackets - pls check on this
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Inflammatory bowel disease (IBD)-like disease in a case of a 33-year old
man with glycogenosis 1b
Version:2Date:13 February 2015
Reviewer: Shanthi Palaniappan
Reviewer's report:
Overall the case report is interesting and this is probably the oldest patient with
glycogenosis presenting with IBD like disease reported . On most parts it is well
written - some corrections as given below.
Minor Essential Revisions:
1. The Back ground and Case presentation should be clearly separated and not
merged together. Also, there should be a heading with discussion and a small
paragraph on conclusion ( now the whole discussion and conclusion is merged
together)
2. In the background the average age at presentation of IBD like disease should
be mentioned and therefore emphasis should be made that this case reports an
older patient
3. Case Presentation - history needs to be a bit more detailed particularly
mentioning the duration of symptoms, any family history of IBD , clinical
examination findings (any evidence of perioral disease / perianal disease etc and
general examination - growth retardation, hepatosplenomagly etc
4. what was the neutrophil count? ( only leukopenia mentioned). Inflammatory
markers on presentation - ESR / CRP?
5. Discussion - should emphasise the older age and possible causes why there
was a delayed presentation in age ( is it because this patients has been on
continuous GCSF and therefore neutrophil count has been maintained higher ? )
6. For Figures - Imaging and endoscopy mixed up
suggest 1A / 1B - CT, 1C - US bowel, 1D/ E - endoscopy, 1F - histology
7. Line 104-107 - grammar correction
Discretionary Revisions:
1. Discussion - other theories postulated on the causes of IBD like disease in
glycogenosis ( and not just chronic infection of gut due to neutropenia)
2. Line 45 - protein level - there is a ? in the brackets - pls check on this
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Inflammatory bowel disease (IBD)-like disease in a case of a 33-year old
man with glycogenosis 1b
Version:2Date:13 February 2015
Reviewer: Shanthi Palaniappan
Reviewer's report:
Overall the case report is interesting and this is probably the oldest patient with
glycogenosis presenting with IBD like disease reported . On most parts it is well
written - some corrections as given below.
Minor Essential Revisions:
1. The Back ground and Case presentation should be clearly separated and not
merged together. Also, there should be a heading with discussion and a small
paragraph on conclusion ( now the whole discussion and conclusion is merged
together)
2. In the background the average age at presentation of IBD like disease should
be mentioned and therefore emphasis should be made that this case reports an
older patient
3. Case Presentation - history needs to be a bit more detailed particularly
mentioning the duration of symptoms, any family history of IBD , clinical
examination findings (any evidence of perioral disease / perianal disease etc and
general examination - growth retardation, hepatosplenomagly etc
4. what was the neutrophil count? ( only leukopenia mentioned). Inflammatory
markers on presentation - ESR / CRP?
5. Discussion - should emphasise the older age and possible causes why there
was a delayed presentation in age ( is it because this patients has been on
continuous GCSF and therefore neutrophil count has been maintained higher ? )
6. For Figures - Imaging and endoscopy mixed up
suggest 1A / 1B - CT, 1C - US bowel, 1D/ E - endoscopy, 1F - histology
7. Line 104-107 - grammar correction
Discretionary Revisions:
1. Discussion - other theories postulated on the causes of IBD like disease in
glycogenosis ( and not just chronic infection of gut due to neutropenia)
2. Line 45 - protein level - there is a ? in the brackets - pls check on this
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant