Reviewer's report
Title:Activation of Liver FGF21 in Hepatocarcinogenesis and During Hepatic
Stress
Version: 2Date:1 February 2013
Reviewer: Katsutaka Oishi
Reviewer's report:
This paper is an interesting and clearly written survey-based study on the hepatic
FGF21 as a stress marker. Considerable evidences suggest that hepatic FGF21
is an indicator of liver function and stress. However, the authors should consider
several points before publication.
Minor comments
1. My concern is the species differences in the physiological function of hepatic
FGF21. Fasting and starvation remarkably induces the hepatic FGF21
expression in rodents, but not in humans.
2. PPARs are involved in the transcriptional regulation of FGF21 as mentioned in
the Discussion section. P53-dependent transactivation of FGF21 is an interesting
and important finding in this study. Please discuss the possibility about the
interaction between these mechanisms.
3. Blood sampling is not non-invasive but minimally-invasive method for patients.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Activation of Liver FGF21 in Hepatocarcinogenesis and During Hepatic
Stress
Version: 2Date:1 February 2013
Reviewer: Katsutaka Oishi
Reviewer's report:
This paper is an interesting and clearly written survey-based study on the hepatic
FGF21 as a stress marker. Considerable evidences suggest that hepatic FGF21
is an indicator of liver function and stress. However, the authors should consider
several points before publication.
Minor comments
1. My concern is the species differences in the physiological function of hepatic
FGF21. Fasting and starvation remarkably induces the hepatic FGF21
expression in rodents, but not in humans.
2. PPARs are involved in the transcriptional regulation of FGF21 as mentioned in
the Discussion section. P53-dependent transactivation of FGF21 is an interesting
and important finding in this study. Please discuss the possibility about the
interaction between these mechanisms.
3. Blood sampling is not non-invasive but minimally-invasive method for patients.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Activation of Liver FGF21 in Hepatocarcinogenesis and During Hepatic
Stress
Version: 2Date:1 February 2013
Reviewer: Katsutaka Oishi
Reviewer's report:
This paper is an interesting and clearly written survey-based study on the hepatic
FGF21 as a stress marker. Considerable evidences suggest that hepatic FGF21
is an indicator of liver function and stress. However, the authors should consider
several points before publication.
Minor comments
1. My concern is the species differences in the physiological function of hepatic
FGF21. Fasting and starvation remarkably induces the hepatic FGF21
expression in rodents, but not in humans.
2. PPARs are involved in the transcriptional regulation of FGF21 as mentioned in
the Discussion section. P53-dependent transactivation of FGF21 is an interesting
and important finding in this study. Please discuss the possibility about the
interaction between these mechanisms.
3. Blood sampling is not non-invasive but minimally-invasive method for patients.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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