Reviewer's report 
 Inhibition of the oxytocin receptors delays gastric emptying Title: 
 1  7 January 2006 Version: Date: 
 Henry P Parkman Reviewer: 
Reviewer's report: 
General 
This study looks at the effect of oxytocin on gastric emptying by studying the effect of oxytocin and 
an oxytocin antagonsit. 
Major Compulsory Revisions 
1. The ultrasonography methodology is confusing. It is not clear that the decrease in antral size 
represents a slowing of gastric emptying. I suggest plotting serial antral size over time similar to what 
was done with the satiety scores. 
2. The manuscript could be improved by reporting the changes in oxytocin levels with meals in this 
particular manuscript, rather than referring to unpublished observations. 
Minor Essential Revisions 
3. Measurement of oxytocin levels would be helpful. Were the oxytocin levels elevated during the 
infusion compared to saline? 
4. The specificity of the antagonist is unclear. 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests. 
Reviewer's report 
 Inhibition of the oxytocin receptors delays gastric emptying Title: 
 1  7 January 2006 Version: Date: 
 Henry P Parkman Reviewer: 
Reviewer's report: 
General 
This study looks at the effect of oxytocin on gastric emptying by studying the effect of oxytocin and 
an oxytocin antagonsit. 
Major Compulsory Revisions 
1. The ultrasonography methodology is confusing. It is not clear that the decrease in antral size 
represents a slowing of gastric emptying. I suggest plotting serial antral size over time similar to what 
was done with the satiety scores. 
2. The manuscript could be improved by reporting the changes in oxytocin levels with meals in this 
particular manuscript, rather than referring to unpublished observations. 
Minor Essential Revisions 
3. Measurement of oxytocin levels would be helpful. Were the oxytocin levels elevated during the 
infusion compared to saline? 
4. The specificity of the antagonist is unclear. 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests. 
Please review this paper.
user
Reviewer's report 
 Inhibition of the oxytocin receptors delays gastric emptying Title: 
 1  7 January 2006 Version: Date: 
 Henry P Parkman Reviewer: 
Reviewer's report: 
General 
This study looks at the effect of oxytocin on gastric emptying by studying the effect of oxytocin and 
an oxytocin antagonsit. 
Major Compulsory Revisions 
1. The ultrasonography methodology is confusing. It is not clear that the decrease in antral size 
represents a slowing of gastric emptying. I suggest plotting serial antral size over time similar to what 
was done with the satiety scores. 
2. The manuscript could be improved by reporting the changes in oxytocin levels with meals in this 
particular manuscript, rather than referring to unpublished observations. 
Minor Essential Revisions 
3. Measurement of oxytocin levels would be helpful. Were the oxytocin levels elevated during the 
infusion compared to saline? 
4. The specificity of the antagonist is unclear. 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests. 
assistant