Title: Proton beam therapy for hepatocellular carcinoma with bile duct invasion
Version: 1 Date: 21 May 2023
Reviewer:  L.H. Wu
Reviewer's report:
Comments:
1.How did the authors discriminate bile duct invasion with other situations (i.e., oppression of
bile duct by tumor). Clinically, it is not surprising that bile duct invasion was found to be only
oppression of bile duct during resection in potentially resectable HCC.
2.How did the authors define central type BDI.
3.Please discuss about the influence of obstructive jaundice on the following therapies.
4.what about the combination usage of targeted therapies or immunotherapies among these
patients since the standard care of advanced HCC was not radiotherapy during the research
period.
5.it did not show typical imaging of HCC (i.e., wash-in and wash-out) in figure 4 and figure 5,
how did the authors establish the diagnosis in the absence of biopsy?
6. Several typo errors need to be corrected. (i.e., Table 2 classificaton)
7. in Table 2, it may be not appropriate to use "recurrence" since radiotherapy is not usually
deemed as radical therapy in HCC.
Title: Proton beam therapy for hepatocellular carcinoma with bile duct invasion
Version: 1 Date: 21 May 2023
Reviewer:  L.H. Wu
Reviewer's report:
Comments:
1.How did the authors discriminate bile duct invasion with other situations (i.e., oppression of
bile duct by tumor). Clinically, it is not surprising that bile duct invasion was found to be only
oppression of bile duct during resection in potentially resectable HCC.
2.How did the authors define central type BDI.
3.Please discuss about the influence of obstructive jaundice on the following therapies.
4.what about the combination usage of targeted therapies or immunotherapies among these
patients since the standard care of advanced HCC was not radiotherapy during the research
period.
5.it did not show typical imaging of HCC (i.e., wash-in and wash-out) in figure 4 and figure 5,
how did the authors establish the diagnosis in the absence of biopsy?
6. Several typo errors need to be corrected. (i.e., Table 2 classificaton)
7. in Table 2, it may be not appropriate to use "recurrence" since radiotherapy is not usually
deemed as radical therapy in HCC.
Please review this paper.
user
Title: Proton beam therapy for hepatocellular carcinoma with bile duct invasion
Version: 1 Date: 21 May 2023
Reviewer:  L.H. Wu
Reviewer's report:
Comments:
1.How did the authors discriminate bile duct invasion with other situations (i.e., oppression of
bile duct by tumor). Clinically, it is not surprising that bile duct invasion was found to be only
oppression of bile duct during resection in potentially resectable HCC.
2.How did the authors define central type BDI.
3.Please discuss about the influence of obstructive jaundice on the following therapies.
4.what about the combination usage of targeted therapies or immunotherapies among these
patients since the standard care of advanced HCC was not radiotherapy during the research
period.
5.it did not show typical imaging of HCC (i.e., wash-in and wash-out) in figure 4 and figure 5,
how did the authors establish the diagnosis in the absence of biopsy?
6. Several typo errors need to be corrected. (i.e., Table 2 classificaton)
7. in Table 2, it may be not appropriate to use "recurrence" since radiotherapy is not usually
deemed as radical therapy in HCC.
assistant