Title: A New Prediction Model of Hepatocellular Carcinoma Based on N7-methylguanosine
Modification
Version: 4 Date: 12 Feb 2023
Reviewer's report:
It is very honored to be invited the reviewing the manuscript entitled “A New Prediction Model
of Hepatocellular Carcinoma Based on N7-methylguanosine Modification”. The manuscript in
novel. Besides, they used many interesting methods. I think the manuscript is within the scope.
Some of the problems should be solved before acceptance.
Firstly, Although the methods are very novel, the author should make a more proper discussion
about the analysis. Besides, the shortness of the informatics analysis also should be involved.
Second, In whole manuscript, there are many errors, which should be checked. The English
writing level should be improved.
Third, in discussion part, I think the authors should focused more on the results.
Fourth, Although all the conclusions are sound, it should be noted that these assays, as such, can
only be viewed as a prioritization method for further analysis. Thus, in the discussion section, it
is necessary to explain all pros and cons of the used assays. For example, limitations of the data
mining approach are thoroughly explained in the following papers:
1. Ye S, Liu Q, Huang K, Jiang X, Zhang X. The comprehensive analysis based study
of perfluorinated compounds-Environmental explanation of bladder cancer progression.
Ecotoxicol Environ Saf. 2022 Jan 1;229:113059. doi: 10.1016/j.ecoenv.2021.113059. Epub
2021 Dec 8. PMID: 34894427.
2. Zhang X, Zhang T, Ren X, Chen X, Wang S, Qin C. Pyrethroids Toxicity to Male
Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies.
Front Endocrinol (Lausanne). 2021 May 27;12:656106. doi: 10.3389/fendo.2021.656106.
PMID: 34122335; PMCID: PMC8190395.
3. Zhang T, Wu J, Zhang X, Zhou X, Wang S, Wang Z. Pharmacophore based in silico study with
laboratory verification-environmental explanation of prostate cancer recurrence. Environ Sci
Pollut Res Int. 2021 Nov;28(43):61581-61591. doi: 10.1007/s11356-021-14970-8. Epub 2021
Jun 28. PMID: 34184217.
4. Ren X, Zhang T, Chen X, Wei X, Tian Y, Li G, Zhang X, Zhang W, You Z, Wang S, Qin
C. Early-life exposure to bisphenol A and reproductive-related outcomes in rodent models: a
systematic review and meta-analysis. Aging (Albany NY). 2020 Sep 30;12(18):18099-18126.
doi: 10.18632/aging.103620. Epub 2020 Sep 30. PMID: 32996894; PMCID: PMC7585097.
Title: A New Prediction Model of Hepatocellular Carcinoma Based on N7-methylguanosine
Modification
Version: 4 Date: 12 Feb 2023
Reviewer's report:
It is very honored to be invited the reviewing the manuscript entitled “A New Prediction Model
of Hepatocellular Carcinoma Based on N7-methylguanosine Modification”. The manuscript in
novel. Besides, they used many interesting methods. I think the manuscript is within the scope.
Some of the problems should be solved before acceptance.
Firstly, Although the methods are very novel, the author should make a more proper discussion
about the analysis. Besides, the shortness of the informatics analysis also should be involved.
Second, In whole manuscript, there are many errors, which should be checked. The English
writing level should be improved.
Third, in discussion part, I think the authors should focused more on the results.
Fourth, Although all the conclusions are sound, it should be noted that these assays, as such, can
only be viewed as a prioritization method for further analysis. Thus, in the discussion section, it
is necessary to explain all pros and cons of the used assays. For example, limitations of the data
mining approach are thoroughly explained in the following papers:
1. Ye S, Liu Q, Huang K, Jiang X, Zhang X. The comprehensive analysis based study
of perfluorinated compounds-Environmental explanation of bladder cancer progression.
Ecotoxicol Environ Saf. 2022 Jan 1;229:113059. doi: 10.1016/j.ecoenv.2021.113059. Epub
2021 Dec 8. PMID: 34894427.
2. Zhang X, Zhang T, Ren X, Chen X, Wang S, Qin C. Pyrethroids Toxicity to Male
Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies.
Front Endocrinol (Lausanne). 2021 May 27;12:656106. doi: 10.3389/fendo.2021.656106.
PMID: 34122335; PMCID: PMC8190395.
3. Zhang T, Wu J, Zhang X, Zhou X, Wang S, Wang Z. Pharmacophore based in silico study with
laboratory verification-environmental explanation of prostate cancer recurrence. Environ Sci
Pollut Res Int. 2021 Nov;28(43):61581-61591. doi: 10.1007/s11356-021-14970-8. Epub 2021
Jun 28. PMID: 34184217.
4. Ren X, Zhang T, Chen X, Wei X, Tian Y, Li G, Zhang X, Zhang W, You Z, Wang S, Qin
C. Early-life exposure to bisphenol A and reproductive-related outcomes in rodent models: a
systematic review and meta-analysis. Aging (Albany NY). 2020 Sep 30;12(18):18099-18126.
doi: 10.18632/aging.103620. Epub 2020 Sep 30. PMID: 32996894; PMCID: PMC7585097.
Please review this paper.
user
Title: A New Prediction Model of Hepatocellular Carcinoma Based on N7-methylguanosine
Modification
Version: 4 Date: 12 Feb 2023
Reviewer's report:
It is very honored to be invited the reviewing the manuscript entitled “A New Prediction Model
of Hepatocellular Carcinoma Based on N7-methylguanosine Modification”. The manuscript in
novel. Besides, they used many interesting methods. I think the manuscript is within the scope.
Some of the problems should be solved before acceptance.
Firstly, Although the methods are very novel, the author should make a more proper discussion
about the analysis. Besides, the shortness of the informatics analysis also should be involved.
Second, In whole manuscript, there are many errors, which should be checked. The English
writing level should be improved.
Third, in discussion part, I think the authors should focused more on the results.
Fourth, Although all the conclusions are sound, it should be noted that these assays, as such, can
only be viewed as a prioritization method for further analysis. Thus, in the discussion section, it
is necessary to explain all pros and cons of the used assays. For example, limitations of the data
mining approach are thoroughly explained in the following papers:
1. Ye S, Liu Q, Huang K, Jiang X, Zhang X. The comprehensive analysis based study
of perfluorinated compounds-Environmental explanation of bladder cancer progression.
Ecotoxicol Environ Saf. 2022 Jan 1;229:113059. doi: 10.1016/j.ecoenv.2021.113059. Epub
2021 Dec 8. PMID: 34894427.
2. Zhang X, Zhang T, Ren X, Chen X, Wang S, Qin C. Pyrethroids Toxicity to Male
Reproductive System and Offspring as a Function of Oxidative Stress Induction: Rodent Studies.
Front Endocrinol (Lausanne). 2021 May 27;12:656106. doi: 10.3389/fendo.2021.656106.
PMID: 34122335; PMCID: PMC8190395.
3. Zhang T, Wu J, Zhang X, Zhou X, Wang S, Wang Z. Pharmacophore based in silico study with
laboratory verification-environmental explanation of prostate cancer recurrence. Environ Sci
Pollut Res Int. 2021 Nov;28(43):61581-61591. doi: 10.1007/s11356-021-14970-8. Epub 2021
Jun 28. PMID: 34184217.
4. Ren X, Zhang T, Chen X, Wei X, Tian Y, Li G, Zhang X, Zhang W, You Z, Wang S, Qin
C. Early-life exposure to bisphenol A and reproductive-related outcomes in rodent models: a
systematic review and meta-analysis. Aging (Albany NY). 2020 Sep 30;12(18):18099-18126.
doi: 10.18632/aging.103620. Epub 2020 Sep 30. PMID: 32996894; PMCID: PMC7585097.
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