Title: Nucleated red blood cell distribution in critically ill patients with acute pancreatitis: a
retrospective cohort study
Version: 1 Date: 06 Sep 2024
Reviewer's report:
I would like to thank the authors for their work in reviewing and responding to the points raised
by the reviewers, resulting in an article of higher quality.
I raise two points to be corrected in this article.
On the one hand, the penultimate sentence of the introduction should be deleted (lines 72 to 74).
It is a sentence that refers to the methodology, which is worked on later.
On the other hand, and more importantly, the idea of using cut-off points for the prognosis of
cases of acute pancreatitis admitted to intensive care has been developed. From a practical point
of view this is of great importance. With a cut-off point of 1.7, the best point according to the
ROC curves for 90-day mortality, the sensitivity obtained is 0.475, and the specificity 0.711.
With these values, its use as a predictor of severity is not very sensitive, and it has a medium-
low specificity. I believe that this point is very important, and should be added to the discussion.
We need better evolution predictors for patients with AP, and NRBC could complete this gap.
Title: Nucleated red blood cell distribution in critically ill patients with acute pancreatitis: a
retrospective cohort study
Version: 1 Date: 06 Sep 2024
Reviewer's report:
I would like to thank the authors for their work in reviewing and responding to the points raised
by the reviewers, resulting in an article of higher quality.
I raise two points to be corrected in this article.
On the one hand, the penultimate sentence of the introduction should be deleted (lines 72 to 74).
It is a sentence that refers to the methodology, which is worked on later.
On the other hand, and more importantly, the idea of using cut-off points for the prognosis of
cases of acute pancreatitis admitted to intensive care has been developed. From a practical point
of view this is of great importance. With a cut-off point of 1.7, the best point according to the
ROC curves for 90-day mortality, the sensitivity obtained is 0.475, and the specificity 0.711.
With these values, its use as a predictor of severity is not very sensitive, and it has a medium-
low specificity. I believe that this point is very important, and should be added to the discussion.
We need better evolution predictors for patients with AP, and NRBC could complete this gap.
Please review this paper.
user
Title: Nucleated red blood cell distribution in critically ill patients with acute pancreatitis: a
retrospective cohort study
Version: 1 Date: 06 Sep 2024
Reviewer's report:
I would like to thank the authors for their work in reviewing and responding to the points raised
by the reviewers, resulting in an article of higher quality.
I raise two points to be corrected in this article.
On the one hand, the penultimate sentence of the introduction should be deleted (lines 72 to 74).
It is a sentence that refers to the methodology, which is worked on later.
On the other hand, and more importantly, the idea of using cut-off points for the prognosis of
cases of acute pancreatitis admitted to intensive care has been developed. From a practical point
of view this is of great importance. With a cut-off point of 1.7, the best point according to the
ROC curves for 90-day mortality, the sensitivity obtained is 0.475, and the specificity 0.711.
With these values, its use as a predictor of severity is not very sensitive, and it has a medium-
low specificity. I believe that this point is very important, and should be added to the discussion.
We need better evolution predictors for patients with AP, and NRBC could complete this gap.
assistant