Title: Dual energy CT-derived quantitative parameters and hematological characteristics predict
pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell
carcinoma patients
Version: 2 Date: 09 Jan 2025
Reviewer's report:
Comments for the Authors:
# Methods
1. “Two phases contrast enhanced DECT images were import into post-processing workstation
(ISP version 12, Philips).” Two phase appears for the first time, it is recommended to mark it
in detail.
2. “The images of all patients were independently delineated by two experienced radiologists.” It
is recommended to supplement the results of inter-observer consistency to ensure the reliability
of data.
# Results
3. “Table 1 displayed the baseline clinical characteristics of all enrolled patients in different
group.” Table 1 only shows the characteristics of all patients, and does not show the
characteristics in different groups.
4. It is recommended to supplement how to obtain AEF-NIC.
# Statistics
5. Sample size of population is very limited. What is the power of your statistical tests with
this sample size? The large number of statistical tests requires some type of multiple testing
correction. Please consider reporting corrected p-values to avoid this issue.
Title: Dual energy CT-derived quantitative parameters and hematological characteristics predict
pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell
carcinoma patients
Version: 2 Date: 09 Jan 2025
Reviewer's report:
Comments for the Authors:
# Methods
1. “Two phases contrast enhanced DECT images were import into post-processing workstation
(ISP version 12, Philips).” Two phase appears for the first time, it is recommended to mark it
in detail.
2. “The images of all patients were independently delineated by two experienced radiologists.” It
is recommended to supplement the results of inter-observer consistency to ensure the reliability
of data.
# Results
3. “Table 1 displayed the baseline clinical characteristics of all enrolled patients in different
group.” Table 1 only shows the characteristics of all patients, and does not show the
characteristics in different groups.
4. It is recommended to supplement how to obtain AEF-NIC.
# Statistics
5. Sample size of population is very limited. What is the power of your statistical tests with
this sample size? The large number of statistical tests requires some type of multiple testing
correction. Please consider reporting corrected p-values to avoid this issue.
Please review this paper.
user
Title: Dual energy CT-derived quantitative parameters and hematological characteristics predict
pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell
carcinoma patients
Version: 2 Date: 09 Jan 2025
Reviewer's report:
Comments for the Authors:
# Methods
1. “Two phases contrast enhanced DECT images were import into post-processing workstation
(ISP version 12, Philips).” Two phase appears for the first time, it is recommended to mark it
in detail.
2. “The images of all patients were independently delineated by two experienced radiologists.” It
is recommended to supplement the results of inter-observer consistency to ensure the reliability
of data.
# Results
3. “Table 1 displayed the baseline clinical characteristics of all enrolled patients in different
group.” Table 1 only shows the characteristics of all patients, and does not show the
characteristics in different groups.
4. It is recommended to supplement how to obtain AEF-NIC.
# Statistics
5. Sample size of population is very limited. What is the power of your statistical tests with
this sample size? The large number of statistical tests requires some type of multiple testing
correction. Please consider reporting corrected p-values to avoid this issue.
assistant