Reviewer's report
Title:Elevated circulating soluble interleukin-2 receptor in patients with chronic
liver diseases is associated with non-classical monocytes
Version: 1Date:20 March 2012
Reviewer: kang xiaonan
Reviewer's report:
Minor essentioal revision
It was long known that sIL-2R levels offer a rapid, reliable, and noninvasive
measure of disease activity, response to therapy, and, in some cases, prognosis
in a broad spectrum of conditions associated with T- or B-cell immune activation.
Elevated sIL-2R has been reported for distinct hepatic disorders but the clinical
significance of this finding remained vague. This work measured serum sIL-2R
levels in 71 patients with chronic liver diseases and analyzed the correlation
between sIL-2R serum concentration and various routine and experimental
laboratory parameters including liver function, heptatic fibrosis, inflammation and
renal function.sIL2-R levels correlated closely with circulating monocytes,
especially non-classical CD14+CD16+ monocytes. sIL-2R could be possibly a
useful marker in chronic liver diseases (CLD).
Here is a question that in Fig 1 ABCF, what does the symbol “ # ” represent ?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Elevated circulating soluble interleukin-2 receptor in patients with chronic
liver diseases is associated with non-classical monocytes
Version: 1Date:20 March 2012
Reviewer: kang xiaonan
Reviewer's report:
Minor essentioal revision
It was long known that sIL-2R levels offer a rapid, reliable, and noninvasive
measure of disease activity, response to therapy, and, in some cases, prognosis
in a broad spectrum of conditions associated with T- or B-cell immune activation.
Elevated sIL-2R has been reported for distinct hepatic disorders but the clinical
significance of this finding remained vague. This work measured serum sIL-2R
levels in 71 patients with chronic liver diseases and analyzed the correlation
between sIL-2R serum concentration and various routine and experimental
laboratory parameters including liver function, heptatic fibrosis, inflammation and
renal function.sIL2-R levels correlated closely with circulating monocytes,
especially non-classical CD14+CD16+ monocytes. sIL-2R could be possibly a
useful marker in chronic liver diseases (CLD).
Here is a question that in Fig 1 ABCF, what does the symbol “ # ” represent ?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Elevated circulating soluble interleukin-2 receptor in patients with chronic
liver diseases is associated with non-classical monocytes
Version: 1Date:20 March 2012
Reviewer: kang xiaonan
Reviewer's report:
Minor essentioal revision
It was long known that sIL-2R levels offer a rapid, reliable, and noninvasive
measure of disease activity, response to therapy, and, in some cases, prognosis
in a broad spectrum of conditions associated with T- or B-cell immune activation.
Elevated sIL-2R has been reported for distinct hepatic disorders but the clinical
significance of this finding remained vague. This work measured serum sIL-2R
levels in 71 patients with chronic liver diseases and analyzed the correlation
between sIL-2R serum concentration and various routine and experimental
laboratory parameters including liver function, heptatic fibrosis, inflammation and
renal function.sIL2-R levels correlated closely with circulating monocytes,
especially non-classical CD14+CD16+ monocytes. sIL-2R could be possibly a
useful marker in chronic liver diseases (CLD).
Here is a question that in Fig 1 ABCF, what does the symbol “ # ” represent ?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant