Title: Celiac Disease Symptom Profiles and their Relationship to Gluten-free Diet Adherence,
Mental Health, and Quality of Life
Version: 2 Date: 23 May 2023
Reviewer's report:
In the paper entitled “Celiac Disease Symptom Profiles and their Relationship to Gluten-free
Diet Adherence, Mental Health, and Quality of Life”, the authors performed a cross-sectional
analysis to elucidate patterns of persistent symptoms and the relationship between those patterns
and gluten-free diet adherence, psychiatric symptoms, and various aspects of quality of life
(QOL) in an online sample of adults with celiac disease.
It is an interesting topic. However, the reviewer believes that the work has several limitations.
The main limitations are:
- the introduction is too long and difficult to read. I would suggest making it shorter, focusing
on the paper's main aim.
- the authors listed 4 aims. I would suggest focusing on one primary aim and a maximum of
two secondary aims
- As the authors reported in the limitations session, the study selected participants who reported a
diagnosis of celiac disease by biopsy, serology, or genetic testing. To reduce the false diagnoses,
the reviewer would suggest performing an analysis limited to patients with biopsy-proven
diagnoses.   
- The self-reported comorbidities could be affected by a high percentage of false diagnoses.
The results show that only 37% of the CD population on  GFD has little to no symptoms and
excellent subjective health
-Almost half of the patients reported suffering from mental health conditions, which could
influence the perception of other diseases.
- I would suggest reporting the main characteristics of the 4 profiles in a table.
Title: Celiac Disease Symptom Profiles and their Relationship to Gluten-free Diet Adherence,
Mental Health, and Quality of Life
Version: 2 Date: 23 May 2023
Reviewer's report:
In the paper entitled “Celiac Disease Symptom Profiles and their Relationship to Gluten-free
Diet Adherence, Mental Health, and Quality of Life”, the authors performed a cross-sectional
analysis to elucidate patterns of persistent symptoms and the relationship between those patterns
and gluten-free diet adherence, psychiatric symptoms, and various aspects of quality of life
(QOL) in an online sample of adults with celiac disease.
It is an interesting topic. However, the reviewer believes that the work has several limitations.
The main limitations are:
- the introduction is too long and difficult to read. I would suggest making it shorter, focusing
on the paper's main aim.
- the authors listed 4 aims. I would suggest focusing on one primary aim and a maximum of
two secondary aims
- As the authors reported in the limitations session, the study selected participants who reported a
diagnosis of celiac disease by biopsy, serology, or genetic testing. To reduce the false diagnoses,
the reviewer would suggest performing an analysis limited to patients with biopsy-proven
diagnoses.   
- The self-reported comorbidities could be affected by a high percentage of false diagnoses.
The results show that only 37% of the CD population on  GFD has little to no symptoms and
excellent subjective health
-Almost half of the patients reported suffering from mental health conditions, which could
influence the perception of other diseases.
- I would suggest reporting the main characteristics of the 4 profiles in a table.
Please review this paper.
user
Title: Celiac Disease Symptom Profiles and their Relationship to Gluten-free Diet Adherence,
Mental Health, and Quality of Life
Version: 2 Date: 23 May 2023
Reviewer's report:
In the paper entitled “Celiac Disease Symptom Profiles and their Relationship to Gluten-free
Diet Adherence, Mental Health, and Quality of Life”, the authors performed a cross-sectional
analysis to elucidate patterns of persistent symptoms and the relationship between those patterns
and gluten-free diet adherence, psychiatric symptoms, and various aspects of quality of life
(QOL) in an online sample of adults with celiac disease.
It is an interesting topic. However, the reviewer believes that the work has several limitations.
The main limitations are:
- the introduction is too long and difficult to read. I would suggest making it shorter, focusing
on the paper's main aim.
- the authors listed 4 aims. I would suggest focusing on one primary aim and a maximum of
two secondary aims
- As the authors reported in the limitations session, the study selected participants who reported a
diagnosis of celiac disease by biopsy, serology, or genetic testing. To reduce the false diagnoses,
the reviewer would suggest performing an analysis limited to patients with biopsy-proven
diagnoses.   
- The self-reported comorbidities could be affected by a high percentage of false diagnoses.
The results show that only 37% of the CD population on  GFD has little to no symptoms and
excellent subjective health
-Almost half of the patients reported suffering from mental health conditions, which could
influence the perception of other diseases.
- I would suggest reporting the main characteristics of the 4 profiles in a table.
assistant