Reviewer's report
Title:Protective effects of hydrogen enriched saline on liver ischemia reperfusion
injury by reducing oxidative stress and HMGB1 release
Version:2Date:25 October 2013
Reviewer: Keliang Xie
Reviewer's report:
The authors have made significant revisions. It is great. However, the
mechanism in this study is still unclear.
Major Compulsory Revisions
The authors should do more experiments, for example, detection of arterial and
venous hydrogen level, measurement of reactive oxygen species (ROS) in liver
tissue, why and how does hydrogen decrease HMGB1 release.
best regards
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests.
Reviewer's report
Title:Protective effects of hydrogen enriched saline on liver ischemia reperfusion
injury by reducing oxidative stress and HMGB1 release
Version:2Date:25 October 2013
Reviewer: Keliang Xie
Reviewer's report:
The authors have made significant revisions. It is great. However, the
mechanism in this study is still unclear.
Major Compulsory Revisions
The authors should do more experiments, for example, detection of arterial and
venous hydrogen level, measurement of reactive oxygen species (ROS) in liver
tissue, why and how does hydrogen decrease HMGB1 release.
best regards
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Protective effects of hydrogen enriched saline on liver ischemia reperfusion
injury by reducing oxidative stress and HMGB1 release
Version:2Date:25 October 2013
Reviewer: Keliang Xie
Reviewer's report:
The authors have made significant revisions. It is great. However, the
mechanism in this study is still unclear.
Major Compulsory Revisions
The authors should do more experiments, for example, detection of arterial and
venous hydrogen level, measurement of reactive oxygen species (ROS) in liver
tissue, why and how does hydrogen decrease HMGB1 release.
best regards
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests.
assistant