Reviewer's report
Title:Assessment of Helicobacter pylori eradication in patients on NSAID
treatment
Version: 2Date:28 August 2012
Reviewer: Atsushi Takagi
Reviewer's report:
Authors reported a post-hoc analysis of a randomized, double blind, placebo
controlled H. pylori eradication trial in patients with NSAID usage, and concluded
that histological examination provided the best sensitivity and specificity for
evaluating success of H. pylori eradication and a percentage change of H .pylori
IgG-antibody titer had better sensitivity and specificity than an absolute titer
change.
This report includes important issues, but there are some problems to be
dissolved.
This clinical trial was studied between 2000 and 2002. Currently, the
determination of eradication by the urea breath test or H. pylori stool antigen test
are recommended (Gut 2012;61:646-664 ). As authors refer, the PPI usage may
result in false negative result. However, the comparison of histology with UBT
and the stool test is necessary, if authors conclude histology is superior methods
to diagnose eradication of H. pylori infection. Histology leads controversial results
(Gut 2012;61:646-664).
A percent change of H. pylori IgG-antibody titer seerm to be not sensitive or
specific. EIA may be recommended in patients treated with PPI.
minor point
This study is a post-hoc analysis, however, treatment regimens must be
described in Methods section.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Assessment of Helicobacter pylori eradication in patients on NSAID
treatment
Version: 2Date:28 August 2012
Reviewer: Atsushi Takagi
Reviewer's report:
Authors reported a post-hoc analysis of a randomized, double blind, placebo
controlled H. pylori eradication trial in patients with NSAID usage, and concluded
that histological examination provided the best sensitivity and specificity for
evaluating success of H. pylori eradication and a percentage change of H .pylori
IgG-antibody titer had better sensitivity and specificity than an absolute titer
change.
This report includes important issues, but there are some problems to be
dissolved.
This clinical trial was studied between 2000 and 2002. Currently, the
determination of eradication by the urea breath test or H. pylori stool antigen test
are recommended (Gut 2012;61:646-664 ). As authors refer, the PPI usage may
result in false negative result. However, the comparison of histology with UBT
and the stool test is necessary, if authors conclude histology is superior methods
to diagnose eradication of H. pylori infection. Histology leads controversial results
(Gut 2012;61:646-664).
A percent change of H. pylori IgG-antibody titer seerm to be not sensitive or
specific. EIA may be recommended in patients treated with PPI.
minor point
This study is a post-hoc analysis, however, treatment regimens must be
described in Methods section.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Assessment of Helicobacter pylori eradication in patients on NSAID
treatment
Version: 2Date:28 August 2012
Reviewer: Atsushi Takagi
Reviewer's report:
Authors reported a post-hoc analysis of a randomized, double blind, placebo
controlled H. pylori eradication trial in patients with NSAID usage, and concluded
that histological examination provided the best sensitivity and specificity for
evaluating success of H. pylori eradication and a percentage change of H .pylori
IgG-antibody titer had better sensitivity and specificity than an absolute titer
change.
This report includes important issues, but there are some problems to be
dissolved.
This clinical trial was studied between 2000 and 2002. Currently, the
determination of eradication by the urea breath test or H. pylori stool antigen test
are recommended (Gut 2012;61:646-664 ). As authors refer, the PPI usage may
result in false negative result. However, the comparison of histology with UBT
and the stool test is necessary, if authors conclude histology is superior methods
to diagnose eradication of H. pylori infection. Histology leads controversial results
(Gut 2012;61:646-664).
A percent change of H. pylori IgG-antibody titer seerm to be not sensitive or
specific. EIA may be recommended in patients treated with PPI.
minor point
This study is a post-hoc analysis, however, treatment regimens must be
described in Methods section.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
assistant