Title: Burden of Gastrointestinal Cancers in Asia, 1990–2019
Version: 0 Date: 09 Feb 2025
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the GBD methodology (CODEm, ST-GPR, DisMod-MR) is mentioned, it might be
helpful to briefly elaborate on these tools for readers who are unfamiliar with them. A sentence
or two explaining how these methods work or why they were chosen could help non-expert
readers appreciate the robustness of the data modeling.
-The use of "EAPC" and "APC" is clearly explained, but further elaboration on interpreting these
values and their clinical or public health implications would add more depth. For example, what
does an increase or decrease in EAPC specifically mean for the future burden of GI cancers in
Asia? This can be discussed briefly for more context.
-While the study mentions using the Population Attributable Fraction (PAF) of risk factors
for GI cancers from the GBD database, the meaning of PAF could be explained more clearly,
particularly for readers who may not be familiar with the concept. A brief sentence on how
PAF helps to quantify the contribution of specific risk factors (like smoking, diet, etc.) would
be useful.
-The mention of R version 4.2.3 for data analysis is appropriate, but more details on the specific
statistical tests or packages used within R could provide added transparency. For example, which
functions or specific libraries were used for the analysis of trends? This is important for readers
interested in replicating or understanding the study's statistical methods in more detail.
-The discussion mentions a "fluctuating" decline in the incidence and mortality of esophageal
and stomach cancers. While this is acknowledged, the reasons for this fluctuation could be
further explored. Are there specific public health efforts or changes in risk factors (e.g., diet,
smoking) that might explain the fluctuations? Providing more context around the trends could
offer more actionable insights for future research and interventions.
-While East Asia and Mongolia are highlighted as having the highest burden of GI cancers,
more detailed insights into specific countries (e.g., China, Japan, and South Korea) would add
value. The differences in healthcare infrastructure, screening programs, and lifestyle factors
across countries in East Asia could help contextualize why some areas have seen more success
in controlling GI cancer burden than others.
Title: Burden of Gastrointestinal Cancers in Asia, 1990–2019
Version: 0 Date: 09 Feb 2025
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the GBD methodology (CODEm, ST-GPR, DisMod-MR) is mentioned, it might be
helpful to briefly elaborate on these tools for readers who are unfamiliar with them. A sentence
or two explaining how these methods work or why they were chosen could help non-expert
readers appreciate the robustness of the data modeling.
-The use of "EAPC" and "APC" is clearly explained, but further elaboration on interpreting these
values and their clinical or public health implications would add more depth. For example, what
does an increase or decrease in EAPC specifically mean for the future burden of GI cancers in
Asia? This can be discussed briefly for more context.
-While the study mentions using the Population Attributable Fraction (PAF) of risk factors
for GI cancers from the GBD database, the meaning of PAF could be explained more clearly,
particularly for readers who may not be familiar with the concept. A brief sentence on how
PAF helps to quantify the contribution of specific risk factors (like smoking, diet, etc.) would
be useful.
-The mention of R version 4.2.3 for data analysis is appropriate, but more details on the specific
statistical tests or packages used within R could provide added transparency. For example, which
functions or specific libraries were used for the analysis of trends? This is important for readers
interested in replicating or understanding the study's statistical methods in more detail.
-The discussion mentions a "fluctuating" decline in the incidence and mortality of esophageal
and stomach cancers. While this is acknowledged, the reasons for this fluctuation could be
further explored. Are there specific public health efforts or changes in risk factors (e.g., diet,
smoking) that might explain the fluctuations? Providing more context around the trends could
offer more actionable insights for future research and interventions.
-While East Asia and Mongolia are highlighted as having the highest burden of GI cancers,
more detailed insights into specific countries (e.g., China, Japan, and South Korea) would add
value. The differences in healthcare infrastructure, screening programs, and lifestyle factors
across countries in East Asia could help contextualize why some areas have seen more success
in controlling GI cancer burden than others.
Please review this paper.
user
Title: Burden of Gastrointestinal Cancers in Asia, 1990–2019
Version: 0 Date: 09 Feb 2025
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the GBD methodology (CODEm, ST-GPR, DisMod-MR) is mentioned, it might be
helpful to briefly elaborate on these tools for readers who are unfamiliar with them. A sentence
or two explaining how these methods work or why they were chosen could help non-expert
readers appreciate the robustness of the data modeling.
-The use of "EAPC" and "APC" is clearly explained, but further elaboration on interpreting these
values and their clinical or public health implications would add more depth. For example, what
does an increase or decrease in EAPC specifically mean for the future burden of GI cancers in
Asia? This can be discussed briefly for more context.
-While the study mentions using the Population Attributable Fraction (PAF) of risk factors
for GI cancers from the GBD database, the meaning of PAF could be explained more clearly,
particularly for readers who may not be familiar with the concept. A brief sentence on how
PAF helps to quantify the contribution of specific risk factors (like smoking, diet, etc.) would
be useful.
-The mention of R version 4.2.3 for data analysis is appropriate, but more details on the specific
statistical tests or packages used within R could provide added transparency. For example, which
functions or specific libraries were used for the analysis of trends? This is important for readers
interested in replicating or understanding the study's statistical methods in more detail.
-The discussion mentions a "fluctuating" decline in the incidence and mortality of esophageal
and stomach cancers. While this is acknowledged, the reasons for this fluctuation could be
further explored. Are there specific public health efforts or changes in risk factors (e.g., diet,
smoking) that might explain the fluctuations? Providing more context around the trends could
offer more actionable insights for future research and interventions.
-While East Asia and Mongolia are highlighted as having the highest burden of GI cancers,
more detailed insights into specific countries (e.g., China, Japan, and South Korea) would add
value. The differences in healthcare infrastructure, screening programs, and lifestyle factors
across countries in East Asia could help contextualize why some areas have seen more success
in controlling GI cancer burden than others.
assistant