Title: Clinicopathological and molecular characteristics of colorectal adenosquamous
carcinoma in an Asian population
Version: 5 Date: 03 Sep 2023
Reviewer's report:
Thank you for your comments. I think the following points need to be corrected:
Major Comments
1. Generally, the right and left colons are divided by the splenic flexure. In addition, Yokoi et al.
In total, 56.4% (40/71) of tumors were located in the right-sided colon of the cecum, ascending
colon, and transverse colon. On the other hand, in this study, 7 cases (63.6%), including Multi,
were on the left side. Because some papers have different conclusions, it is necessary to discuss
this difference in the discussion.
2. In general, MSI-H/dMMR metastatic colorectal cancer is reported to predominantly occur
in the right-sided colon and is a poor prognostic factor (Gut 2012;61:847-854). In this study, 3
cases (27.7%) had dMMR, but it is not clear from Fig. 6 and Table 1 whether these 3 cases were
right-sided or left-sided colon. We asked you to change Fig. 6 to make it clearer, but it is still very
difficult to understand this figure, so we recommend that it be written as a table. Please include
age, sex, survival time, primary site, genetic mutations, and other information to make it easier
to understand. In this case, it would be better to put the table after (27.3%) on line 183 of p. 8.
Minor Comments
In Fig. 1, the median age was 53 years (50-59), but in Fig. 6, it was 22-73 years. Please check.
Title: Clinicopathological and molecular characteristics of colorectal adenosquamous
carcinoma in an Asian population
Version: 5 Date: 03 Sep 2023
Reviewer's report:
Thank you for your comments. I think the following points need to be corrected:
Major Comments
1. Generally, the right and left colons are divided by the splenic flexure. In addition, Yokoi et al.
In total, 56.4% (40/71) of tumors were located in the right-sided colon of the cecum, ascending
colon, and transverse colon. On the other hand, in this study, 7 cases (63.6%), including Multi,
were on the left side. Because some papers have different conclusions, it is necessary to discuss
this difference in the discussion.
2. In general, MSI-H/dMMR metastatic colorectal cancer is reported to predominantly occur
in the right-sided colon and is a poor prognostic factor (Gut 2012;61:847-854). In this study, 3
cases (27.7%) had dMMR, but it is not clear from Fig. 6 and Table 1 whether these 3 cases were
right-sided or left-sided colon. We asked you to change Fig. 6 to make it clearer, but it is still very
difficult to understand this figure, so we recommend that it be written as a table. Please include
age, sex, survival time, primary site, genetic mutations, and other information to make it easier
to understand. In this case, it would be better to put the table after (27.3%) on line 183 of p. 8.
Minor Comments
In Fig. 1, the median age was 53 years (50-59), but in Fig. 6, it was 22-73 years. Please check.
Please review this paper.
user
Title: Clinicopathological and molecular characteristics of colorectal adenosquamous
carcinoma in an Asian population
Version: 5 Date: 03 Sep 2023
Reviewer's report:
Thank you for your comments. I think the following points need to be corrected:
Major Comments
1. Generally, the right and left colons are divided by the splenic flexure. In addition, Yokoi et al.
In total, 56.4% (40/71) of tumors were located in the right-sided colon of the cecum, ascending
colon, and transverse colon. On the other hand, in this study, 7 cases (63.6%), including Multi,
were on the left side. Because some papers have different conclusions, it is necessary to discuss
this difference in the discussion.
2. In general, MSI-H/dMMR metastatic colorectal cancer is reported to predominantly occur
in the right-sided colon and is a poor prognostic factor (Gut 2012;61:847-854). In this study, 3
cases (27.7%) had dMMR, but it is not clear from Fig. 6 and Table 1 whether these 3 cases were
right-sided or left-sided colon. We asked you to change Fig. 6 to make it clearer, but it is still very
difficult to understand this figure, so we recommend that it be written as a table. Please include
age, sex, survival time, primary site, genetic mutations, and other information to make it easier
to understand. In this case, it would be better to put the table after (27.3%) on line 183 of p. 8.
Minor Comments
In Fig. 1, the median age was 53 years (50-59), but in Fig. 6, it was 22-73 years. Please check.
assistant