Title: Association between serum uric acid-to-creatinine ratio and non-alcoholic fatty liver
disease: a cross-sectional study in Chinese non-obese people with a normal range of low-density
lipoprotein cholesterol
Version: 0 Date: 25 Jul 2022
Reviewer's report:
The authors tested the association between serum uric acid-to-creatinine (SUA/Scr) and
NAFLD. The study includes large sample size and data presentation is clear.  However, study
concept and aim of the study is unclear and unacceptable.
1. Manuscript is descriptive rather than hypothesis verification. The aim of the number of
statistical analyses remains unclear.
2. The authors mention about the possible use of SUA/Scr for diagnosis for NAFLD. However,
there are a number of tools such as FLI, ZJU index and HSI to predict NAFLD. ROC analysis is
missing in the present manuscript. Cut-off values of SUA/Scr was not provided and significance
of SUA/Scr in terms of the clinical implementation remains unclear.
Title: Association between serum uric acid-to-creatinine ratio and non-alcoholic fatty liver
disease: a cross-sectional study in Chinese non-obese people with a normal range of low-density
lipoprotein cholesterol
Version: 0 Date: 25 Jul 2022
Reviewer's report:
The authors tested the association between serum uric acid-to-creatinine (SUA/Scr) and
NAFLD. The study includes large sample size and data presentation is clear.  However, study
concept and aim of the study is unclear and unacceptable.
1. Manuscript is descriptive rather than hypothesis verification. The aim of the number of
statistical analyses remains unclear.
2. The authors mention about the possible use of SUA/Scr for diagnosis for NAFLD. However,
there are a number of tools such as FLI, ZJU index and HSI to predict NAFLD. ROC analysis is
missing in the present manuscript. Cut-off values of SUA/Scr was not provided and significance
of SUA/Scr in terms of the clinical implementation remains unclear.
Please review this paper.
user
Title: Association between serum uric acid-to-creatinine ratio and non-alcoholic fatty liver
disease: a cross-sectional study in Chinese non-obese people with a normal range of low-density
lipoprotein cholesterol
Version: 0 Date: 25 Jul 2022
Reviewer's report:
The authors tested the association between serum uric acid-to-creatinine (SUA/Scr) and
NAFLD. The study includes large sample size and data presentation is clear.  However, study
concept and aim of the study is unclear and unacceptable.
1. Manuscript is descriptive rather than hypothesis verification. The aim of the number of
statistical analyses remains unclear.
2. The authors mention about the possible use of SUA/Scr for diagnosis for NAFLD. However,
there are a number of tools such as FLI, ZJU index and HSI to predict NAFLD. ROC analysis is
missing in the present manuscript. Cut-off values of SUA/Scr was not provided and significance
of SUA/Scr in terms of the clinical implementation remains unclear.
assistant