Reviewer's report
Title:Comparison of accuracy of fibrosis degree classifications by liver biopsy
and non invasive tests in chronic hepatitis C
Version: 1Date:27 January 2011
Reviewer: Ryota Masuzaki
Reviewer's report:
Boursier et al. examined diagnostic accuracy using several noninvasive tests. It
is well-written and properly reported in accordance with STARD statement.
The authors mentioned that Fibrometer surpassed local pathologists’ reading. It
is not big surprise because it is well known fact that pathological diagnosis is
prone to inter-intra observer variability and blood test is less prone to.
What is the meaning of making fibrosis classification by non-invasive tests?
METAIR score and other pathological fibrosis stages were diagnosed based on
histological morphology. If the authors want to make classifications, it should be
divided based on clinical endpoint.
True endpoints of chronic hepatitis should be decompensation,
hepatocarcinogenesis, and survival. Besides, continuous valuable and its wide
dynamic range are the big advantage of non-invasive test.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Comparison of accuracy of fibrosis degree classifications by liver biopsy
and non invasive tests in chronic hepatitis C
Version: 1Date:27 January 2011
Reviewer: Ryota Masuzaki
Reviewer's report:
Boursier et al. examined diagnostic accuracy using several noninvasive tests. It
is well-written and properly reported in accordance with STARD statement.
The authors mentioned that Fibrometer surpassed local pathologists’ reading. It
is not big surprise because it is well known fact that pathological diagnosis is
prone to inter-intra observer variability and blood test is less prone to.
What is the meaning of making fibrosis classification by non-invasive tests?
METAIR score and other pathological fibrosis stages were diagnosed based on
histological morphology. If the authors want to make classifications, it should be
divided based on clinical endpoint.
True endpoints of chronic hepatitis should be decompensation,
hepatocarcinogenesis, and survival. Besides, continuous valuable and its wide
dynamic range are the big advantage of non-invasive test.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Comparison of accuracy of fibrosis degree classifications by liver biopsy
and non invasive tests in chronic hepatitis C
Version: 1Date:27 January 2011
Reviewer: Ryota Masuzaki
Reviewer's report:
Boursier et al. examined diagnostic accuracy using several noninvasive tests. It
is well-written and properly reported in accordance with STARD statement.
The authors mentioned that Fibrometer surpassed local pathologists’ reading. It
is not big surprise because it is well known fact that pathological diagnosis is
prone to inter-intra observer variability and blood test is less prone to.
What is the meaning of making fibrosis classification by non-invasive tests?
METAIR score and other pathological fibrosis stages were diagnosed based on
histological morphology. If the authors want to make classifications, it should be
divided based on clinical endpoint.
True endpoints of chronic hepatitis should be decompensation,
hepatocarcinogenesis, and survival. Besides, continuous valuable and its wide
dynamic range are the big advantage of non-invasive test.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant