Title: Lower serum chloride concentrations are associated with increased risk of mortality in
critically ill cirrhotic patients: an analysis of the MIMIC-III database
Version: 1 Date: 17 Dec 2020
Reviewer's report:
The authors presented an interesting relation between serum chloride concentrations and in
hospital mortality among cirrrhotic patients.  Logistic regression analysis was used to assess this
relation. However, some modifications should be conducted.
Major Comments:
1.More variables should be addeded in Table 1, for example, hemoglobin#platelet#White blood
cells, albumin.
2.Some variables with clinical significance but without  statistical significance in univariate
analysis should also been added in multivariate Logistic regression analysis , like age sex.
3. ROC analysis should be conducted to evaluate the predictive performance of serum chloride;
4. As a study of electrolyte#I suggest  authors eliminate patients with chronic kidney disease(at
least stage 5).
Minor Comments:
Please revise again your grammar and spelling.
Title: Lower serum chloride concentrations are associated with increased risk of mortality in
critically ill cirrhotic patients: an analysis of the MIMIC-III database
Version: 1 Date: 17 Dec 2020
Reviewer's report:
The authors presented an interesting relation between serum chloride concentrations and in
hospital mortality among cirrrhotic patients.  Logistic regression analysis was used to assess this
relation. However, some modifications should be conducted.
Major Comments:
1.More variables should be addeded in Table 1, for example, hemoglobin#platelet#White blood
cells, albumin.
2.Some variables with clinical significance but without  statistical significance in univariate
analysis should also been added in multivariate Logistic regression analysis , like age sex.
3. ROC analysis should be conducted to evaluate the predictive performance of serum chloride;
4. As a study of electrolyte#I suggest  authors eliminate patients with chronic kidney disease(at
least stage 5).
Minor Comments:
Please revise again your grammar and spelling.
Please review this paper.
user
Title: Lower serum chloride concentrations are associated with increased risk of mortality in
critically ill cirrhotic patients: an analysis of the MIMIC-III database
Version: 1 Date: 17 Dec 2020
Reviewer's report:
The authors presented an interesting relation between serum chloride concentrations and in
hospital mortality among cirrrhotic patients.  Logistic regression analysis was used to assess this
relation. However, some modifications should be conducted.
Major Comments:
1.More variables should be addeded in Table 1, for example, hemoglobin#platelet#White blood
cells, albumin.
2.Some variables with clinical significance but without  statistical significance in univariate
analysis should also been added in multivariate Logistic regression analysis , like age sex.
3. ROC analysis should be conducted to evaluate the predictive performance of serum chloride;
4. As a study of electrolyte#I suggest  authors eliminate patients with chronic kidney disease(at
least stage 5).
Minor Comments:
Please revise again your grammar and spelling.
assistant