Title: Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic
agents on digestive system function, intestinal immunity and prognosis in patients with
metastatic colorectal carcinoma: a quasi-experimental study
Version: 1 Date: 10 Jan 2025
Reviewer's report:
Thank you for submitting the revised manuscript and for your detailed responses to the
reviewers' comments. The revisions have addressed the key concerns effectively, including
clarifying the study's prospective design, standardizing group labels, and improving statistical
clarity. The authors have also adequately acknowledged limitations, such as the single-center
cohort and the need for further mechanistic exploration through additional molecular analyses.
The discussion now more clearly reflects the study's results, aligning conclusions with the
presented data. Overall, the manuscript is substantially improved, and I recommend it for
acceptance in its current form.
Title: Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic
agents on digestive system function, intestinal immunity and prognosis in patients with
metastatic colorectal carcinoma: a quasi-experimental study
Version: 1 Date: 10 Jan 2025
Reviewer's report:
Thank you for submitting the revised manuscript and for your detailed responses to the
reviewers' comments. The revisions have addressed the key concerns effectively, including
clarifying the study's prospective design, standardizing group labels, and improving statistical
clarity. The authors have also adequately acknowledged limitations, such as the single-center
cohort and the need for further mechanistic exploration through additional molecular analyses.
The discussion now more clearly reflects the study's results, aligning conclusions with the
presented data. Overall, the manuscript is substantially improved, and I recommend it for
acceptance in its current form.
Please review this paper.
user
Title: Effect of probiotics combined with immune checkpoint suppressors and chemotherapeutic
agents on digestive system function, intestinal immunity and prognosis in patients with
metastatic colorectal carcinoma: a quasi-experimental study
Version: 1 Date: 10 Jan 2025
Reviewer's report:
Thank you for submitting the revised manuscript and for your detailed responses to the
reviewers' comments. The revisions have addressed the key concerns effectively, including
clarifying the study's prospective design, standardizing group labels, and improving statistical
clarity. The authors have also adequately acknowledged limitations, such as the single-center
cohort and the need for further mechanistic exploration through additional molecular analyses.
The discussion now more clearly reflects the study's results, aligning conclusions with the
presented data. Overall, the manuscript is substantially improved, and I recommend it for
acceptance in its current form.
assistant