Title: Impact of perioperative immunonutrition on postoperative outcomes in
pancreaticoduodenectomy: a systematic review and meta-analysis of randomized controlled
trials.
Version: 0 Date: 11 Sep 2024
Reviewer:  Giuseppe Esposito
Reviewer's report:
I am grateful for the opportunity to review the manuscript.
I recommend that BMC Gastroenterology accept for publication this meta-analysis on
the effect of immunonutrition on the postoperative outcome of patients who underwent
pancreaticoduodenectomy.
The Materials and Methods section is comprehensive and meticulous, particularly with regard to
the precise evaluation of the risk of bias and the assessment of the included studies. Furthermore,
the results of the meta-analysis are robust, reflecting the high quality of the included studies, all
of which were randomised controlled trials.
In the case of continuous data provided as median and range (LOS in Fig. 6 for Gade et al. 2016
and for Joe et al. 2006), the method employed by the author to estimate the mean and standard
deviation, which the author included in the meta-analysis (Fig. 6), should be reported in the
statistical analysis section.
Therefore, if the method described by Hozo et al. (*) is employed to estimate the mean and
standard deviation in Fig. 6:
- the estimated mean of the Intervention Group of Gade et al. 2016 should be 14.5
- the estimated mean of the Control Group of Gade et al. 2016 should be 17.5
- the SD of the Control Group in Jo et al. 2006 should be 9.25 or 9.3
*https://doi.org/10.1186/1471-2288-5-13
Hozo, S. P., Djulbegovic, B. & Hozo, I. Estimating the mean and variance from the median,
range, and the size of a sample. BMC Medical Research Methodology 5, 13 (2005).
Furthermore, in the case of continuous data presented as a median and interquartile range (IQR),
the mean and standard deviation should be estimated using the methodologies outlined by Luo
et al. and Wan et al.
- Luo D, Wan X, Liu J, Tong T (2018) Optimally estimating the sample mean from the sample
size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res 27(6):1785–805
- Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation
from the sample size, median, range and/or interquartile range. BMC Med Res Methodol
14(1):135
Finally, the total number of patient included in the Control Group of Gianotti et al. 2000 should
be modified in 73 (not 70) , in accordance with the original paper.
The manuscript is well-written and merits publication in BMC Gastroenterology.
Title: Impact of perioperative immunonutrition on postoperative outcomes in
pancreaticoduodenectomy: a systematic review and meta-analysis of randomized controlled
trials.
Version: 0 Date: 11 Sep 2024
Reviewer:  Giuseppe Esposito
Reviewer's report:
I am grateful for the opportunity to review the manuscript.
I recommend that BMC Gastroenterology accept for publication this meta-analysis on
the effect of immunonutrition on the postoperative outcome of patients who underwent
pancreaticoduodenectomy.
The Materials and Methods section is comprehensive and meticulous, particularly with regard to
the precise evaluation of the risk of bias and the assessment of the included studies. Furthermore,
the results of the meta-analysis are robust, reflecting the high quality of the included studies, all
of which were randomised controlled trials.
In the case of continuous data provided as median and range (LOS in Fig. 6 for Gade et al. 2016
and for Joe et al. 2006), the method employed by the author to estimate the mean and standard
deviation, which the author included in the meta-analysis (Fig. 6), should be reported in the
statistical analysis section.
Therefore, if the method described by Hozo et al. (*) is employed to estimate the mean and
standard deviation in Fig. 6:
- the estimated mean of the Intervention Group of Gade et al. 2016 should be 14.5
- the estimated mean of the Control Group of Gade et al. 2016 should be 17.5
- the SD of the Control Group in Jo et al. 2006 should be 9.25 or 9.3
*https://doi.org/10.1186/1471-2288-5-13
Hozo, S. P., Djulbegovic, B. & Hozo, I. Estimating the mean and variance from the median,
range, and the size of a sample. BMC Medical Research Methodology 5, 13 (2005).
Furthermore, in the case of continuous data presented as a median and interquartile range (IQR),
the mean and standard deviation should be estimated using the methodologies outlined by Luo
et al. and Wan et al.
- Luo D, Wan X, Liu J, Tong T (2018) Optimally estimating the sample mean from the sample
size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res 27(6):1785–805
- Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation
from the sample size, median, range and/or interquartile range. BMC Med Res Methodol
14(1):135
Finally, the total number of patient included in the Control Group of Gianotti et al. 2000 should
be modified in 73 (not 70) , in accordance with the original paper.
The manuscript is well-written and merits publication in BMC Gastroenterology.
Please review this paper.
user
Title: Impact of perioperative immunonutrition on postoperative outcomes in
pancreaticoduodenectomy: a systematic review and meta-analysis of randomized controlled
trials.
Version: 0 Date: 11 Sep 2024
Reviewer:  Giuseppe Esposito
Reviewer's report:
I am grateful for the opportunity to review the manuscript.
I recommend that BMC Gastroenterology accept for publication this meta-analysis on
the effect of immunonutrition on the postoperative outcome of patients who underwent
pancreaticoduodenectomy.
The Materials and Methods section is comprehensive and meticulous, particularly with regard to
the precise evaluation of the risk of bias and the assessment of the included studies. Furthermore,
the results of the meta-analysis are robust, reflecting the high quality of the included studies, all
of which were randomised controlled trials.
In the case of continuous data provided as median and range (LOS in Fig. 6 for Gade et al. 2016
and for Joe et al. 2006), the method employed by the author to estimate the mean and standard
deviation, which the author included in the meta-analysis (Fig. 6), should be reported in the
statistical analysis section.
Therefore, if the method described by Hozo et al. (*) is employed to estimate the mean and
standard deviation in Fig. 6:
- the estimated mean of the Intervention Group of Gade et al. 2016 should be 14.5
- the estimated mean of the Control Group of Gade et al. 2016 should be 17.5
- the SD of the Control Group in Jo et al. 2006 should be 9.25 or 9.3
*https://doi.org/10.1186/1471-2288-5-13
Hozo, S. P., Djulbegovic, B. & Hozo, I. Estimating the mean and variance from the median,
range, and the size of a sample. BMC Medical Research Methodology 5, 13 (2005).
Furthermore, in the case of continuous data presented as a median and interquartile range (IQR),
the mean and standard deviation should be estimated using the methodologies outlined by Luo
et al. and Wan et al.
- Luo D, Wan X, Liu J, Tong T (2018) Optimally estimating the sample mean from the sample
size, median, mid-range, and/or mid-quartile range. Stat Methods Med Res 27(6):1785–805
- Wan X, Wang W, Liu J, Tong T (2014) Estimating the sample mean and standard deviation
from the sample size, median, range and/or interquartile range. BMC Med Res Methodol
14(1):135
Finally, the total number of patient included in the Control Group of Gianotti et al. 2000 should
be modified in 73 (not 70) , in accordance with the original paper.
The manuscript is well-written and merits publication in BMC Gastroenterology.
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