Title: Effectiveness and Safety of Tofacitinib in the Management of Ulcerative Colitis: A
Brazilian Observational Multicentric Study.
Version: 4 Date: 17 Jan 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
The manuscript is a well-designed and valuable observational study evaluating the long-term
effectiveness and safety of tofacitinib in managing moderate-to-severe ulcerative colitis in a
Brazilian cohort. The multicenter design, inclusion of 127 patients, and extensive follow-up
of 30 months provide robust and clinically relevant real-world data. The clear stratification of
biologic-naïve and biologic-exposed groups, alongside rigorous statistical methods, strengthens
the reliability of the findings, while the safety outcomes align well with international reports.
This study successfully addresses a significant gap in real-world evidence from Latin America,
offering insights that bridge the gap between clinical trials and practical applications. We thank
the authors for their important contribution to advancing the understanding and management of
ulcerative colitis.
Title: Effectiveness and Safety of Tofacitinib in the Management of Ulcerative Colitis: A
Brazilian Observational Multicentric Study.
Version: 4 Date: 17 Jan 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
The manuscript is a well-designed and valuable observational study evaluating the long-term
effectiveness and safety of tofacitinib in managing moderate-to-severe ulcerative colitis in a
Brazilian cohort. The multicenter design, inclusion of 127 patients, and extensive follow-up
of 30 months provide robust and clinically relevant real-world data. The clear stratification of
biologic-naïve and biologic-exposed groups, alongside rigorous statistical methods, strengthens
the reliability of the findings, while the safety outcomes align well with international reports.
This study successfully addresses a significant gap in real-world evidence from Latin America,
offering insights that bridge the gap between clinical trials and practical applications. We thank
the authors for their important contribution to advancing the understanding and management of
ulcerative colitis.
Please review this paper.
user
Title: Effectiveness and Safety of Tofacitinib in the Management of Ulcerative Colitis: A
Brazilian Observational Multicentric Study.
Version: 4 Date: 17 Jan 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
The manuscript is a well-designed and valuable observational study evaluating the long-term
effectiveness and safety of tofacitinib in managing moderate-to-severe ulcerative colitis in a
Brazilian cohort. The multicenter design, inclusion of 127 patients, and extensive follow-up
of 30 months provide robust and clinically relevant real-world data. The clear stratification of
biologic-naïve and biologic-exposed groups, alongside rigorous statistical methods, strengthens
the reliability of the findings, while the safety outcomes align well with international reports.
This study successfully addresses a significant gap in real-world evidence from Latin America,
offering insights that bridge the gap between clinical trials and practical applications. We thank
the authors for their important contribution to advancing the understanding and management of
ulcerative colitis.
assistant