Reviewer ’s report  
 
Title: Rate and determinants of non -adherence to a gluten -free diet and nutritional status 
asses sment in children and adolescents with celiac disease in a tertiary Brazilian referral center: a 
cross -sectional and retrospective study.  
 
Version: 1 Date: 10 Nov 2017  
 
Reviewer: Giuseppe Chiarioni  
 
Reviewer's report:  
 
I read with interest the MS "Rate and determinants of non -adherence to a gluten -free diet and 
nutritional status assess ment in children and adolescents with celiac disease in a tertiary 
Brazilian referral center: a cross -sectional and retrospective study" by Maraci Rodrigues et al. It 
is a well designed study dealing with a relevant issue in Celiac Disease (CD) Management.  I 
have few concerns, namely: the Authors seem to underscore the relevance of parental training in 
Pediatric: my personal suggestion would be to look for potential difference in diet adherence 
when questionnaires were filled in by parents plus entertaining  the issue of programs to improve 
parental approach to pediatric CD, b) I would like to see the full questionnaire included as 
supplementary material. No additional suggestions on this side.   
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing in terests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in t he future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to th e content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do y ou have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interest  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Rate and determinants of non -adherence to a gluten -free diet and nutritional status 
asses sment in children and adolescents with celiac disease in a tertiary Brazilian referral center: a 
cross -sectional and retrospective study.  
 
Version: 1 Date: 10 Nov 2017  
 
Reviewer: Giuseppe Chiarioni  
 
Reviewer's report:  
 
I read with interest the MS "Rate and determinants of non -adherence to a gluten -free diet and 
nutritional status assess ment in children and adolescents with celiac disease in a tertiary 
Brazilian referral center: a cross -sectional and retrospective study" by Maraci Rodrigues et al. It 
is a well designed study dealing with a relevant issue in Celiac Disease (CD) Management.  I 
have few concerns, namely: the Authors seem to underscore the relevance of parental training in 
Pediatric: my personal suggestion would be to look for potential difference in diet adherence 
when questionnaires were filled in by parents plus entertaining  the issue of programs to improve 
parental approach to pediatric CD, b) I would like to see the full questionnaire included as 
supplementary material. No additional suggestions on this side.   
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing in terests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in t he future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to th e content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do y ou have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interest  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Rate and determinants of non -adherence to a gluten -free diet and nutritional status 
asses sment in children and adolescents with celiac disease in a tertiary Brazilian referral center: a 
cross -sectional and retrospective study.  
 
Version: 1 Date: 10 Nov 2017  
 
Reviewer: Giuseppe Chiarioni  
 
Reviewer's report:  
 
I read with interest the MS "Rate and determinants of non -adherence to a gluten -free diet and 
nutritional status assess ment in children and adolescents with celiac disease in a tertiary 
Brazilian referral center: a cross -sectional and retrospective study" by Maraci Rodrigues et al. It 
is a well designed study dealing with a relevant issue in Celiac Disease (CD) Management.  I 
have few concerns, namely: the Authors seem to underscore the relevance of parental training in 
Pediatric: my personal suggestion would be to look for potential difference in diet adherence 
when questionnaires were filled in by parents plus entertaining  the issue of programs to improve 
parental approach to pediatric CD, b) I would like to see the full questionnaire included as 
supplementary material. No additional suggestions on this side.   
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing in terests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in t he future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to th e content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do y ou have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interest  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant