Title: Identification of differentially methylated regions associated with both liver fibrosis and
hepatocellular carcinoma
Version: 0 Date: 04 Sep 2023
Reviewer:  Maarit Tiirikainen
Reviewer's report:
The authors provide a nice article on DMR analysis of GEO data sets produced from samples
with  liver cirrhosis and HCC of either viral or alcohol etiology.
This paper is continuation of the  same group's analysis of  DMRs in NAFLD and especially
fibrotic liver. The paper is of interest to the field and in general well-written. The only concern is
that when describing the results from the first GEO dataset, it is sometimes hard to follow which
etiology is in question for the cirrhosis and  HCC. I would sugget using a prefix to separate the
two etiologies, such as a-cirrhosis and v-cirrhosis.
Title: Identification of differentially methylated regions associated with both liver fibrosis and
hepatocellular carcinoma
Version: 0 Date: 04 Sep 2023
Reviewer:  Maarit Tiirikainen
Reviewer's report:
The authors provide a nice article on DMR analysis of GEO data sets produced from samples
with  liver cirrhosis and HCC of either viral or alcohol etiology.
This paper is continuation of the  same group's analysis of  DMRs in NAFLD and especially
fibrotic liver. The paper is of interest to the field and in general well-written. The only concern is
that when describing the results from the first GEO dataset, it is sometimes hard to follow which
etiology is in question for the cirrhosis and  HCC. I would sugget using a prefix to separate the
two etiologies, such as a-cirrhosis and v-cirrhosis.
Please review this paper.
user
Title: Identification of differentially methylated regions associated with both liver fibrosis and
hepatocellular carcinoma
Version: 0 Date: 04 Sep 2023
Reviewer:  Maarit Tiirikainen
Reviewer's report:
The authors provide a nice article on DMR analysis of GEO data sets produced from samples
with  liver cirrhosis and HCC of either viral or alcohol etiology.
This paper is continuation of the  same group's analysis of  DMRs in NAFLD and especially
fibrotic liver. The paper is of interest to the field and in general well-written. The only concern is
that when describing the results from the first GEO dataset, it is sometimes hard to follow which
etiology is in question for the cirrhosis and  HCC. I would sugget using a prefix to separate the
two etiologies, such as a-cirrhosis and v-cirrhosis.
assistant