Title: Nomogram for predicting the overall survival of underweight patients with colorectal
cancer: A clinical study
Version: 1 Date: 01 Jan 2023
Reviewer:  Zhenhui Li
Reviewer's report:
The author used data from the national registry to investigate the prognosis of underweight
patients and developed a nomogram to predict overall survival (OS) in underweight patients,
which is an interesting study. I have some comments.
1. patients were randomly allocated to the training and validation sets, respectively, at an 8:2
ratio, why?
2. The research should report the calibration of nomogram.
3. The delong test should be used to compare the C-index between the nomogram and TNM
stage system.
4. Underweigh patients have poor prognosis, which is known to all. Hence, the first part of result
is unnecessary.
5. Some mistakes were found in the manuscript, for example “The OS of the underweight group
was significantly worse than that of the non-underweight group (5-year OS, 78.1% vs. 62.9.0%
vs. 78.1%, P<0.001; Figure 1).”
Title: Nomogram for predicting the overall survival of underweight patients with colorectal
cancer: A clinical study
Version: 1 Date: 01 Jan 2023
Reviewer:  Zhenhui Li
Reviewer's report:
The author used data from the national registry to investigate the prognosis of underweight
patients and developed a nomogram to predict overall survival (OS) in underweight patients,
which is an interesting study. I have some comments.
1. patients were randomly allocated to the training and validation sets, respectively, at an 8:2
ratio, why?
2. The research should report the calibration of nomogram.
3. The delong test should be used to compare the C-index between the nomogram and TNM
stage system.
4. Underweigh patients have poor prognosis, which is known to all. Hence, the first part of result
is unnecessary.
5. Some mistakes were found in the manuscript, for example “The OS of the underweight group
was significantly worse than that of the non-underweight group (5-year OS, 78.1% vs. 62.9.0%
vs. 78.1%, P<0.001; Figure 1).”
Please review this paper.
user
Title: Nomogram for predicting the overall survival of underweight patients with colorectal
cancer: A clinical study
Version: 1 Date: 01 Jan 2023
Reviewer:  Zhenhui Li
Reviewer's report:
The author used data from the national registry to investigate the prognosis of underweight
patients and developed a nomogram to predict overall survival (OS) in underweight patients,
which is an interesting study. I have some comments.
1. patients were randomly allocated to the training and validation sets, respectively, at an 8:2
ratio, why?
2. The research should report the calibration of nomogram.
3. The delong test should be used to compare the C-index between the nomogram and TNM
stage system.
4. Underweigh patients have poor prognosis, which is known to all. Hence, the first part of result
is unnecessary.
5. Some mistakes were found in the manuscript, for example “The OS of the underweight group
was significantly worse than that of the non-underweight group (5-year OS, 78.1% vs. 62.9.0%
vs. 78.1%, P<0.001; Figure 1).”
assistant