Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactase
non-persistence is not related to symptoms
Version: 2Date:11 November 2009
Reviewer: Irma Jarvela
Reviewer's report:
The article has been improved a lot.
I have some minor comments:
1. The paper by Bernardes-Silva CF, Pereira AC, de Fátima Alves da Mota G,
Krieger JE, Laudanna AA.Lactase persistence/non-persistence variants,
C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS
patients. Clin Chim Acta. 2007 Nov-Dec;386(1-2):7-11 is closely related to this
work but not mentioned in the manuscript. I recommend the authors to refer to
this paper.
2. Ref #22 is old. Recently, more variants have been found to be candidates of
lactase persistence/non-persistence. See publications:
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell
K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo
TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Convergent
adaptation of human lactase persistence in Africa and Europe. Nat Genet 2007;
39: 31-40.
Ingram CJE, Elamin FF, Mulcare CA, Weale ME, Tarekegn A, Raga TO, Bekele
E, Elamin FM, Thomas MG, Bradman N, Swallow DM. A novel polymorphism
associated with lactose tolerance in Africa: multiple causes for lactase
persistence? Hum Genet 2007; 120: 779-88.
Jarvela I, Torniainen S, Kolho KL. Molecular genetics of human lactase
deficiencies. Ann Med. 2009 Jul 28:1-8. [Epub ahead of print]
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactase
non-persistence is not related to symptoms
Version: 2Date:11 November 2009
Reviewer: Irma Jarvela
Reviewer's report:
The article has been improved a lot.
I have some minor comments:
1. The paper by Bernardes-Silva CF, Pereira AC, de Fátima Alves da Mota G,
Krieger JE, Laudanna AA.Lactase persistence/non-persistence variants,
C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS
patients. Clin Chim Acta. 2007 Nov-Dec;386(1-2):7-11 is closely related to this
work but not mentioned in the manuscript. I recommend the authors to refer to
this paper.
2. Ref #22 is old. Recently, more variants have been found to be candidates of
lactase persistence/non-persistence. See publications:
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell
K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo
TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Convergent
adaptation of human lactase persistence in Africa and Europe. Nat Genet 2007;
39: 31-40.
Ingram CJE, Elamin FF, Mulcare CA, Weale ME, Tarekegn A, Raga TO, Bekele
E, Elamin FM, Thomas MG, Bradman N, Swallow DM. A novel polymorphism
associated with lactose tolerance in Africa: multiple causes for lactase
persistence? Hum Genet 2007; 120: 779-88.
Jarvela I, Torniainen S, Kolho KL. Molecular genetics of human lactase
deficiencies. Ann Med. 2009 Jul 28:1-8. [Epub ahead of print]
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactase
non-persistence is not related to symptoms
Version: 2Date:11 November 2009
Reviewer: Irma Jarvela
Reviewer's report:
The article has been improved a lot.
I have some minor comments:
1. The paper by Bernardes-Silva CF, Pereira AC, de Fátima Alves da Mota G,
Krieger JE, Laudanna AA.Lactase persistence/non-persistence variants,
C/T_13910 and G/A_22018, as a diagnostic tool for lactose intolerance in IBS
patients. Clin Chim Acta. 2007 Nov-Dec;386(1-2):7-11 is closely related to this
work but not mentioned in the manuscript. I recommend the authors to refer to
this paper.
2. Ref #22 is old. Recently, more variants have been found to be candidates of
lactase persistence/non-persistence. See publications:
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, Powell
K, Mortensen HM, Hirbo JB, Osman M, Ibrahim M, Omar SA, Lema G, Nyambo
TB, Ghori J, Bumpstead S, Pritchard JK, Wray GA, Deloukas P. Convergent
adaptation of human lactase persistence in Africa and Europe. Nat Genet 2007;
39: 31-40.
Ingram CJE, Elamin FF, Mulcare CA, Weale ME, Tarekegn A, Raga TO, Bekele
E, Elamin FM, Thomas MG, Bradman N, Swallow DM. A novel polymorphism
associated with lactose tolerance in Africa: multiple causes for lactase
persistence? Hum Genet 2007; 120: 779-88.
Jarvela I, Torniainen S, Kolho KL. Molecular genetics of human lactase
deficiencies. Ann Med. 2009 Jul 28:1-8. [Epub ahead of print]
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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