Title: Can Visceral Adipose Tissue and Skeletal Muscle PredictRecurrence of Newly Diagnosed
Crohn’s Disease in Different Treatments
Version: 4 Date: 10 Jan 2022
Reviewer's report:
I have read the revised manuscript.
I have many questions on the aims and results of this study.
1. Is primary treatment and maintenance treatment the same including doses?
2. This study seems to compare the effectiveness of 5-ASA and steroid plus azathioprine because
biologics group did not show any predictive factors.
3. Authors are discussing the significance of adipose tissue around gut (VAT) and skeletal
muscle through this study but strong treatment by biologics did noy show the merit of measuring
these factors.
4.  At the first treatment how authors select treatments? Based on disease activity including
CDAI? We do not see the policy of these selection in this study
5. What is the most important message to clinician who are responsible on the treatment of CD
patients to select or change treatment as appropriate time point.
Title: Can Visceral Adipose Tissue and Skeletal Muscle PredictRecurrence of Newly Diagnosed
Crohn’s Disease in Different Treatments
Version: 4 Date: 10 Jan 2022
Reviewer's report:
I have read the revised manuscript.
I have many questions on the aims and results of this study.
1. Is primary treatment and maintenance treatment the same including doses?
2. This study seems to compare the effectiveness of 5-ASA and steroid plus azathioprine because
biologics group did not show any predictive factors.
3. Authors are discussing the significance of adipose tissue around gut (VAT) and skeletal
muscle through this study but strong treatment by biologics did noy show the merit of measuring
these factors.
4.  At the first treatment how authors select treatments? Based on disease activity including
CDAI? We do not see the policy of these selection in this study
5. What is the most important message to clinician who are responsible on the treatment of CD
patients to select or change treatment as appropriate time point.
Please review this paper.
user
Title: Can Visceral Adipose Tissue and Skeletal Muscle PredictRecurrence of Newly Diagnosed
Crohn’s Disease in Different Treatments
Version: 4 Date: 10 Jan 2022
Reviewer's report:
I have read the revised manuscript.
I have many questions on the aims and results of this study.
1. Is primary treatment and maintenance treatment the same including doses?
2. This study seems to compare the effectiveness of 5-ASA and steroid plus azathioprine because
biologics group did not show any predictive factors.
3. Authors are discussing the significance of adipose tissue around gut (VAT) and skeletal
muscle through this study but strong treatment by biologics did noy show the merit of measuring
these factors.
4.  At the first treatment how authors select treatments? Based on disease activity including
CDAI? We do not see the policy of these selection in this study
5. What is the most important message to clinician who are responsible on the treatment of CD
patients to select or change treatment as appropriate time point.
assistant