Title: Efficacy and safety of anti-PD-1/PD-L1 therapy in the treatment of advanced colorectal
cancer: A meta-analysis
Version: 1 Date: 09 Jul 2022
Reviewer:  Giulia Poli
Reviewer's report:
In mixed studies we suggest ROBINS-I and RoB 2 tools.The QUADAS-2 is to prefer in the
acuracy diagnostic methanalysis, instead of intervention metanalisys or proportion metanalisys.
In mixed studies we suggest ROBINS-I and RoB 2 tools.The QUADAS-2 is to prefer in the
acuracy diagnostic methanalysis, instead of intervention metanalisys or proportion metanalisys.
Statistical analisys: evaluation of  primary end points:
objective response rate
disease control rate
progress free survival rate
overall survival rate
Specifical outcome tools  are nedeed in a proportion metanalisys, because this is not an acuracy
diagnostic methanalysis. Those are not clearly specified in the statistical analisys report. The
between study heterogeneity is correctly described. A < or >50% I2 index is specified in the
fixed effet or a random effect model.
Forest plots: negative mesurementes are not allowed in a proportion metanalisys. Fig. 4a
presents negative mesurements; in Fig 6a some studies have a negative confidence interval.
We suggest to specifie how to measure your primary and also secondary end points.
We suggest to present in this study your Influence Analisys. (this is not important to specifie an
influence analisys on the secondary end points)
Title: Efficacy and safety of anti-PD-1/PD-L1 therapy in the treatment of advanced colorectal
cancer: A meta-analysis
Version: 1 Date: 09 Jul 2022
Reviewer:  Giulia Poli
Reviewer's report:
In mixed studies we suggest ROBINS-I and RoB 2 tools.The QUADAS-2 is to prefer in the
acuracy diagnostic methanalysis, instead of intervention metanalisys or proportion metanalisys.
In mixed studies we suggest ROBINS-I and RoB 2 tools.The QUADAS-2 is to prefer in the
acuracy diagnostic methanalysis, instead of intervention metanalisys or proportion metanalisys.
Statistical analisys: evaluation of  primary end points:
objective response rate
disease control rate
progress free survival rate
overall survival rate
Specifical outcome tools  are nedeed in a proportion metanalisys, because this is not an acuracy
diagnostic methanalysis. Those are not clearly specified in the statistical analisys report. The
between study heterogeneity is correctly described. A < or >50% I2 index is specified in the
fixed effet or a random effect model.
Forest plots: negative mesurementes are not allowed in a proportion metanalisys. Fig. 4a
presents negative mesurements; in Fig 6a some studies have a negative confidence interval.
We suggest to specifie how to measure your primary and also secondary end points.
We suggest to present in this study your Influence Analisys. (this is not important to specifie an
influence analisys on the secondary end points)
Please review this paper.
user
Title: Efficacy and safety of anti-PD-1/PD-L1 therapy in the treatment of advanced colorectal
cancer: A meta-analysis
Version: 1 Date: 09 Jul 2022
Reviewer:  Giulia Poli
Reviewer's report:
In mixed studies we suggest ROBINS-I and RoB 2 tools.The QUADAS-2 is to prefer in the
acuracy diagnostic methanalysis, instead of intervention metanalisys or proportion metanalisys.
In mixed studies we suggest ROBINS-I and RoB 2 tools.The QUADAS-2 is to prefer in the
acuracy diagnostic methanalysis, instead of intervention metanalisys or proportion metanalisys.
Statistical analisys: evaluation of  primary end points:
objective response rate
disease control rate
progress free survival rate
overall survival rate
Specifical outcome tools  are nedeed in a proportion metanalisys, because this is not an acuracy
diagnostic methanalysis. Those are not clearly specified in the statistical analisys report. The
between study heterogeneity is correctly described. A < or >50% I2 index is specified in the
fixed effet or a random effect model.
Forest plots: negative mesurementes are not allowed in a proportion metanalisys. Fig. 4a
presents negative mesurements; in Fig 6a some studies have a negative confidence interval.
We suggest to specifie how to measure your primary and also secondary end points.
We suggest to present in this study your Influence Analisys. (this is not important to specifie an
influence analisys on the secondary end points)
assistant