Title: Effectiveness and safety evaluation of terlipressin in the treatment of intestinal paralysis
in end-stage liver disease
Version: 0 Date: 25 Feb 2025
Reviewer's report:
This is a non-controlled study on whether terlipressin is effective and safe in patients with
ESLD with intestinal non-mechanical bowel obstruction. The authors describe two parts: one
retrospective and the other prospective, but the methodology and treatment arm assignment are
difficult to disentangle. Main issues:
1. The article refers to dynamic intestinal obstruction. I strongly believe the authors actually
mean adynamic obstruction or intestinal paralysis which makes sense in the context. Dynamic
intestinal obstruction is mechanical and generally requires surgery.
2. If I understand correctly the methodology describes a prospective observational study in which
assignment to intervention (i.e. terlipressin) happened according to patient choice ("Patients
were assigned to either the terlipressin group or the conventional treatment group according to
their wishes."). This significantly reduces any validity for the findings
3. Inclusion/exclusion criteria and outcomes are unclear and pose significant risk of bias
Title: Effectiveness and safety evaluation of terlipressin in the treatment of intestinal paralysis
in end-stage liver disease
Version: 0 Date: 25 Feb 2025
Reviewer's report:
This is a non-controlled study on whether terlipressin is effective and safe in patients with
ESLD with intestinal non-mechanical bowel obstruction. The authors describe two parts: one
retrospective and the other prospective, but the methodology and treatment arm assignment are
difficult to disentangle. Main issues:
1. The article refers to dynamic intestinal obstruction. I strongly believe the authors actually
mean adynamic obstruction or intestinal paralysis which makes sense in the context. Dynamic
intestinal obstruction is mechanical and generally requires surgery.
2. If I understand correctly the methodology describes a prospective observational study in which
assignment to intervention (i.e. terlipressin) happened according to patient choice ("Patients
were assigned to either the terlipressin group or the conventional treatment group according to
their wishes."). This significantly reduces any validity for the findings
3. Inclusion/exclusion criteria and outcomes are unclear and pose significant risk of bias
Please review this paper.
user
Title: Effectiveness and safety evaluation of terlipressin in the treatment of intestinal paralysis
in end-stage liver disease
Version: 0 Date: 25 Feb 2025
Reviewer's report:
This is a non-controlled study on whether terlipressin is effective and safe in patients with
ESLD with intestinal non-mechanical bowel obstruction. The authors describe two parts: one
retrospective and the other prospective, but the methodology and treatment arm assignment are
difficult to disentangle. Main issues:
1. The article refers to dynamic intestinal obstruction. I strongly believe the authors actually
mean adynamic obstruction or intestinal paralysis which makes sense in the context. Dynamic
intestinal obstruction is mechanical and generally requires surgery.
2. If I understand correctly the methodology describes a prospective observational study in which
assignment to intervention (i.e. terlipressin) happened according to patient choice ("Patients
were assigned to either the terlipressin group or the conventional treatment group according to
their wishes."). This significantly reduces any validity for the findings
3. Inclusion/exclusion criteria and outcomes are unclear and pose significant risk of bias
assistant