Title: Waistline to thigh circumference ratio as a predictor of MAFLD: A health care worker
study with 2-year follow-up
Version: 0 Date: 06 Nov 2023
Reviewer:  Giuseppe Guido Maria Scarlata
Reviewer's report:
The manuscript offers a detailed analysis of the waist-to-thigh ratio as a predictor of NAFLD.
Patients were properly stratified and the results are robust. Moreover, according to the authors,
this is the novelty of the study. However, the paper is lacking in content in the other sections.
I  have some suggestions for improving the manuscript:
Introduction:
1. Clinical features of NAFLD patients should be highlighted. I suggest citing these recent
papers:
- https://doi.org/10.3390/medicina59111935
- 10.3389/fendo.2023.1062341
- 10.1159/000530845
2. It should be explained how NAFLD is diagnosed. The authors used ultrasound, so the pros
and cons of this method should be highlighted.
3. "However, there are few reports on the relationship between waist-to-thigh ratio and NAFLD
in healthcare workers." What are they? They should be cited and addressed later in the
discussion.
Materials and methods:
1. The principle of the Cobas c 501 autoanalyzer method, Roche Diagnostics, Germany, should
be specified.
Results:
1. A workflow should be included to better explain how the 2790 patients were enrolled.
2. The caption of the tables should probably be moved above them.
3. A legend for the tables is needed to better explain the terms used.
Discussions and conclusions:
1. The few works on the topic, highlighted in the introduction, should be discussed in depth.
2. Is the incidence of NAFLD calculated by you in agreement or disagreement with the literature?
3. The conclusions should be expanded.
The manuscript should be proofread for english language and typos.
Title: Waistline to thigh circumference ratio as a predictor of MAFLD: A health care worker
study with 2-year follow-up
Version: 0 Date: 06 Nov 2023
Reviewer:  Giuseppe Guido Maria Scarlata
Reviewer's report:
The manuscript offers a detailed analysis of the waist-to-thigh ratio as a predictor of NAFLD.
Patients were properly stratified and the results are robust. Moreover, according to the authors,
this is the novelty of the study. However, the paper is lacking in content in the other sections.
I  have some suggestions for improving the manuscript:
Introduction:
1. Clinical features of NAFLD patients should be highlighted. I suggest citing these recent
papers:
- https://doi.org/10.3390/medicina59111935
- 10.3389/fendo.2023.1062341
- 10.1159/000530845
2. It should be explained how NAFLD is diagnosed. The authors used ultrasound, so the pros
and cons of this method should be highlighted.
3. "However, there are few reports on the relationship between waist-to-thigh ratio and NAFLD
in healthcare workers." What are they? They should be cited and addressed later in the
discussion.
Materials and methods:
1. The principle of the Cobas c 501 autoanalyzer method, Roche Diagnostics, Germany, should
be specified.
Results:
1. A workflow should be included to better explain how the 2790 patients were enrolled.
2. The caption of the tables should probably be moved above them.
3. A legend for the tables is needed to better explain the terms used.
Discussions and conclusions:
1. The few works on the topic, highlighted in the introduction, should be discussed in depth.
2. Is the incidence of NAFLD calculated by you in agreement or disagreement with the literature?
3. The conclusions should be expanded.
The manuscript should be proofread for english language and typos.
Please review this paper.
user
Title: Waistline to thigh circumference ratio as a predictor of MAFLD: A health care worker
study with 2-year follow-up
Version: 0 Date: 06 Nov 2023
Reviewer:  Giuseppe Guido Maria Scarlata
Reviewer's report:
The manuscript offers a detailed analysis of the waist-to-thigh ratio as a predictor of NAFLD.
Patients were properly stratified and the results are robust. Moreover, according to the authors,
this is the novelty of the study. However, the paper is lacking in content in the other sections.
I  have some suggestions for improving the manuscript:
Introduction:
1. Clinical features of NAFLD patients should be highlighted. I suggest citing these recent
papers:
- https://doi.org/10.3390/medicina59111935
- 10.3389/fendo.2023.1062341
- 10.1159/000530845
2. It should be explained how NAFLD is diagnosed. The authors used ultrasound, so the pros
and cons of this method should be highlighted.
3. "However, there are few reports on the relationship between waist-to-thigh ratio and NAFLD
in healthcare workers." What are they? They should be cited and addressed later in the
discussion.
Materials and methods:
1. The principle of the Cobas c 501 autoanalyzer method, Roche Diagnostics, Germany, should
be specified.
Results:
1. A workflow should be included to better explain how the 2790 patients were enrolled.
2. The caption of the tables should probably be moved above them.
3. A legend for the tables is needed to better explain the terms used.
Discussions and conclusions:
1. The few works on the topic, highlighted in the introduction, should be discussed in depth.
2. Is the incidence of NAFLD calculated by you in agreement or disagreement with the literature?
3. The conclusions should be expanded.
The manuscript should be proofread for english language and typos.
assistant