Title: Cholesterol-modified prognostic nutritional index as an independent prognostic
biomarker in primary biliary cholangitis patients
Version: 3 Date: 13 Apr 2025
Reviewer:  Martin Janicko
Reviewer's report:
The authors did not improve the manuscript according to my suggestions.
I consider not incorpotating baseline fibrosis and treatment response into the mutivariate
regression a major problem that invalidates the conclusions.
Although the authors have included FIB-4 score it is striking that it was not asociated with
mortality even as an univariate predictor.
Also authors have not included the information on treatment response, which is again, major
determinant of poor prognosis.
Authors have not added number at risk under KM curves.
Authors say that they dont have enough data to calculate other prognostic scores GLOBE
prognostic score, but UK PBC score can be calculated notheless.
Title: Cholesterol-modified prognostic nutritional index as an independent prognostic
biomarker in primary biliary cholangitis patients
Version: 3 Date: 13 Apr 2025
Reviewer:  Martin Janicko
Reviewer's report:
The authors did not improve the manuscript according to my suggestions.
I consider not incorpotating baseline fibrosis and treatment response into the mutivariate
regression a major problem that invalidates the conclusions.
Although the authors have included FIB-4 score it is striking that it was not asociated with
mortality even as an univariate predictor.
Also authors have not included the information on treatment response, which is again, major
determinant of poor prognosis.
Authors have not added number at risk under KM curves.
Authors say that they dont have enough data to calculate other prognostic scores GLOBE
prognostic score, but UK PBC score can be calculated notheless.
Please review this paper.
user
Title: Cholesterol-modified prognostic nutritional index as an independent prognostic
biomarker in primary biliary cholangitis patients
Version: 3 Date: 13 Apr 2025
Reviewer:  Martin Janicko
Reviewer's report:
The authors did not improve the manuscript according to my suggestions.
I consider not incorpotating baseline fibrosis and treatment response into the mutivariate
regression a major problem that invalidates the conclusions.
Although the authors have included FIB-4 score it is striking that it was not asociated with
mortality even as an univariate predictor.
Also authors have not included the information on treatment response, which is again, major
determinant of poor prognosis.
Authors have not added number at risk under KM curves.
Authors say that they dont have enough data to calculate other prognostic scores GLOBE
prognostic score, but UK PBC score can be calculated notheless.
assistant