Reviewer's report 
 Measurement of the total antioxidant response using a novel automated method in subjects Title: 
with nonalcoholic steatohepatitis 
 7  29 August 2005 Version: Date: 
 Giulio Marchesini Reviewer: 
Reviewer's report: 
General 
The study has improved much. It remains purely confirmatory, but the new method may help define the role of oxidative stress in NASH as well as in other clinical conditions. Here are a few additional suggestions to improve the manuscript further. 
Minor Essential Revisions 
1. Both in the abstract and in the discussion any conclusion stating that oxidative stress plays a role 
in the pathogenesis of NASH should be omitted. In a cross-sectional analysis, the association between the variables does not predict which comes first, and no pathogenic clue can be derived. 
The authors are invited to comment on association, not on pathogenesis. 
2. Histological data should be transferred into the method section. 3. Figures should be redrawn omitting half points in the x-axis. In a categorical system, only units 
should be presented. R should be changed into rs. 
4. The whole manuscript needs some editing for the English language (avoid to repeat Zone 3 
perisinusoidal/pericellular fibrosis in histology; No …. neither …. nor in the result section; etc..). 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research Level of interest: 
interests 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests 
Reviewer's report 
 Measurement of the total antioxidant response using a novel automated method in subjects Title: 
with nonalcoholic steatohepatitis 
 7  29 August 2005 Version: Date: 
 Giulio Marchesini Reviewer: 
Reviewer's report: 
General 
The study has improved much. It remains purely confirmatory, but the new method may help define the role of oxidative stress in NASH as well as in other clinical conditions. Here are a few additional suggestions to improve the manuscript further. 
Minor Essential Revisions 
1. Both in the abstract and in the discussion any conclusion stating that oxidative stress plays a role 
in the pathogenesis of NASH should be omitted. In a cross-sectional analysis, the association between the variables does not predict which comes first, and no pathogenic clue can be derived. 
The authors are invited to comment on association, not on pathogenesis. 
2. Histological data should be transferred into the method section. 3. Figures should be redrawn omitting half points in the x-axis. In a categorical system, only units 
should be presented. R should be changed into rs. 
4. The whole manuscript needs some editing for the English language (avoid to repeat Zone 3 
perisinusoidal/pericellular fibrosis in histology; No …. neither …. nor in the result section; etc..). 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research Level of interest: 
interests 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests 
Please review this paper.
user
Reviewer's report 
 Measurement of the total antioxidant response using a novel automated method in subjects Title: 
with nonalcoholic steatohepatitis 
 7  29 August 2005 Version: Date: 
 Giulio Marchesini Reviewer: 
Reviewer's report: 
General 
The study has improved much. It remains purely confirmatory, but the new method may help define the role of oxidative stress in NASH as well as in other clinical conditions. Here are a few additional suggestions to improve the manuscript further. 
Minor Essential Revisions 
1. Both in the abstract and in the discussion any conclusion stating that oxidative stress plays a role 
in the pathogenesis of NASH should be omitted. In a cross-sectional analysis, the association between the variables does not predict which comes first, and no pathogenic clue can be derived. 
The authors are invited to comment on association, not on pathogenesis. 
2. Histological data should be transferred into the method section. 3. Figures should be redrawn omitting half points in the x-axis. In a categorical system, only units 
should be presented. R should be changed into rs. 
4. The whole manuscript needs some editing for the English language (avoid to repeat Zone 3 
perisinusoidal/pericellular fibrosis in histology; No …. neither …. nor in the result section; etc..). 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research Level of interest: 
interests 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests 
assistant