Title: CT Features with Histopathological Correlation in Inflammatory Versus Benign &
Malignant Neoplastic Appendiceal Mucoceles: A Retrospective Cross-Sectional Study
Version: 1 Date: 31 Oct 2024
Reviewer's report:
Thank you for submitting this paper. Differentiation of benign vs malignant lesions is important
as it alters the operative approach. Some specific comments about your paper are:
1. you only used a single search phrase of "appendiceal mucocele". If you use other phrases,
you might find more cases.
2.in the introduction, the first sentence contradicts the second.
3.Introduction: do you have a better figure for incidence? % in excised lesions is largely
meaningless.
4. You talk about 3 groups; benign, low grade/hyperplasia and malignant.  I think that this
should be simplified based upon what operation you would ideally get. Who gets a simple
appendicectomy, vs caecectomy, versus hemicolectomy? This is the clinical question that needs
to be answered, so the paper should be set up that way.
5. Under CT findings you state "Soft-tissue thickening was seen in 15%"Soft-tissue thickening
was seen in 15%,". This represents 4.65 patients. How is that possible?
6. Table 4 is inflammatory vs benign. This needs to address malignant to be clinically relevant.
7. did you consider doing a multivariate analysis?
Title: CT Features with Histopathological Correlation in Inflammatory Versus Benign &
Malignant Neoplastic Appendiceal Mucoceles: A Retrospective Cross-Sectional Study
Version: 1 Date: 31 Oct 2024
Reviewer's report:
Thank you for submitting this paper. Differentiation of benign vs malignant lesions is important
as it alters the operative approach. Some specific comments about your paper are:
1. you only used a single search phrase of "appendiceal mucocele". If you use other phrases,
you might find more cases.
2.in the introduction, the first sentence contradicts the second.
3.Introduction: do you have a better figure for incidence? % in excised lesions is largely
meaningless.
4. You talk about 3 groups; benign, low grade/hyperplasia and malignant.  I think that this
should be simplified based upon what operation you would ideally get. Who gets a simple
appendicectomy, vs caecectomy, versus hemicolectomy? This is the clinical question that needs
to be answered, so the paper should be set up that way.
5. Under CT findings you state "Soft-tissue thickening was seen in 15%"Soft-tissue thickening
was seen in 15%,". This represents 4.65 patients. How is that possible?
6. Table 4 is inflammatory vs benign. This needs to address malignant to be clinically relevant.
7. did you consider doing a multivariate analysis?
Please review this paper.
user
Title: CT Features with Histopathological Correlation in Inflammatory Versus Benign &
Malignant Neoplastic Appendiceal Mucoceles: A Retrospective Cross-Sectional Study
Version: 1 Date: 31 Oct 2024
Reviewer's report:
Thank you for submitting this paper. Differentiation of benign vs malignant lesions is important
as it alters the operative approach. Some specific comments about your paper are:
1. you only used a single search phrase of "appendiceal mucocele". If you use other phrases,
you might find more cases.
2.in the introduction, the first sentence contradicts the second.
3.Introduction: do you have a better figure for incidence? % in excised lesions is largely
meaningless.
4. You talk about 3 groups; benign, low grade/hyperplasia and malignant.  I think that this
should be simplified based upon what operation you would ideally get. Who gets a simple
appendicectomy, vs caecectomy, versus hemicolectomy? This is the clinical question that needs
to be answered, so the paper should be set up that way.
5. Under CT findings you state "Soft-tissue thickening was seen in 15%"Soft-tissue thickening
was seen in 15%,". This represents 4.65 patients. How is that possible?
6. Table 4 is inflammatory vs benign. This needs to address malignant to be clinically relevant.
7. did you consider doing a multivariate analysis?
assistant