Title: Mortality rates and risk factors in 1,412 Japanese patients with decompensated hepatitis
C virus-related cirrhosis: A retrospective long-term cohort study
Version: 5 Date: 21 Mar 2021
Reviewer's report:
Thanks for the responses, most of my comments have been well answered. But I still have a
few questions.
1. Although neither “sex” nor “AST” was extracted as a significant factor in the multivariate
analyses, the specific P-values should be list in the Table 2.
2. Authors have already added the description of symptomatic treatments in the Discussion
section (Page 10, lines 208-215), and it should be more reasonable if these words are moved
to Result section.
3. Authors have revised the words that “In our results, the eGFR and serum sodium level
were important factors as components of the MELD score. Platelets reflect the degree of liver
fibrosis. The AFP level reflects not only liver cancer, but also severe inflammation and fibrosis
progression.” (page 12, lines 255-258), and these words should be supported by some references
and further improved.
Title: Mortality rates and risk factors in 1,412 Japanese patients with decompensated hepatitis
C virus-related cirrhosis: A retrospective long-term cohort study
Version: 5 Date: 21 Mar 2021
Reviewer's report:
Thanks for the responses, most of my comments have been well answered. But I still have a
few questions.
1. Although neither “sex” nor “AST” was extracted as a significant factor in the multivariate
analyses, the specific P-values should be list in the Table 2.
2. Authors have already added the description of symptomatic treatments in the Discussion
section (Page 10, lines 208-215), and it should be more reasonable if these words are moved
to Result section.
3. Authors have revised the words that “In our results, the eGFR and serum sodium level
were important factors as components of the MELD score. Platelets reflect the degree of liver
fibrosis. The AFP level reflects not only liver cancer, but also severe inflammation and fibrosis
progression.” (page 12, lines 255-258), and these words should be supported by some references
and further improved.
Please review this paper.
user
Title: Mortality rates and risk factors in 1,412 Japanese patients with decompensated hepatitis
C virus-related cirrhosis: A retrospective long-term cohort study
Version: 5 Date: 21 Mar 2021
Reviewer's report:
Thanks for the responses, most of my comments have been well answered. But I still have a
few questions.
1. Although neither “sex” nor “AST” was extracted as a significant factor in the multivariate
analyses, the specific P-values should be list in the Table 2.
2. Authors have already added the description of symptomatic treatments in the Discussion
section (Page 10, lines 208-215), and it should be more reasonable if these words are moved
to Result section.
3. Authors have revised the words that “In our results, the eGFR and serum sodium level
were important factors as components of the MELD score. Platelets reflect the degree of liver
fibrosis. The AFP level reflects not only liver cancer, but also severe inflammation and fibrosis
progression.” (page 12, lines 255-258), and these words should be supported by some references
and further improved.
assistant