Title: High output stoma after surgery for rectal cancer - A risk factor for Low Anterior
Resection Syndrome?
Version: 1 Date: 05 Dec 2024
Reviewer:  Kil-Yong Lee
Reviewer's report:
1. Major concern in this study is the ambiguous diagnosis of HOS.
1) When is the check time for high output stoma?
2) Please describe whether high output is continued and whether it is well controlled.
3) The authors mentioned that HOS might affect the sympathetic nervous system, but it only
applies to cases with continued high output stoma.
2. Another concern is the anastomosis level. The major cause of major LARS is the lower
level of anastomosis. Please describe the related factors, such as the location of rectal cancer or
anastomotic level from the anal verge.
Title: High output stoma after surgery for rectal cancer - A risk factor for Low Anterior
Resection Syndrome?
Version: 1 Date: 05 Dec 2024
Reviewer:  Kil-Yong Lee
Reviewer's report:
1. Major concern in this study is the ambiguous diagnosis of HOS.
1) When is the check time for high output stoma?
2) Please describe whether high output is continued and whether it is well controlled.
3) The authors mentioned that HOS might affect the sympathetic nervous system, but it only
applies to cases with continued high output stoma.
2. Another concern is the anastomosis level. The major cause of major LARS is the lower
level of anastomosis. Please describe the related factors, such as the location of rectal cancer or
anastomotic level from the anal verge.
Please review this paper.
user
Title: High output stoma after surgery for rectal cancer - A risk factor for Low Anterior
Resection Syndrome?
Version: 1 Date: 05 Dec 2024
Reviewer:  Kil-Yong Lee
Reviewer's report:
1. Major concern in this study is the ambiguous diagnosis of HOS.
1) When is the check time for high output stoma?
2) Please describe whether high output is continued and whether it is well controlled.
3) The authors mentioned that HOS might affect the sympathetic nervous system, but it only
applies to cases with continued high output stoma.
2. Another concern is the anastomosis level. The major cause of major LARS is the lower
level of anastomosis. Please describe the related factors, such as the location of rectal cancer or
anastomotic level from the anal verge.
assistant