Reviewer's report
Title:Endoscopic optical diagnosis provides high diagnostic accuracy of
esophageal squamous cell carcinoma
Version:1Date:10 June 2014
Reviewer: kenro kawada
Reviewer's report:
Endoscopic optical diagnosis provides high diagnostic accuracy of esophageal
squamous cell carcinoma#
Thank you for allowing me the opportunity to review this manuscript. In this
study, the authors compared the accuracy of endoscopic and biopsy diagnosis. It
is believed that the gold standard of diagnosis is biopsy, but sometimes, there is
sampling error. The authors mentioned the usefulness of magnifying endoscopy
with NBI system. It is very interesting and useful, although it has some problems
to be solved before acceptance in its present form.
Minor revise
Major point
# The illustration [Figure 3,4,5,6,] does not match Figure Legend (Figure 3, 4a
4b, 4c,4d). please correct the mistake.
# Figure2 + Figure 3= Figure2??
The difference the accuracy between NBI with biopsy ?? please correct it.
# It is divided into three categories( Cancer, Undetermined, No cancer) of the
NBI diagnosis, please show the typical images each.
Minor point
Line 3 on page 6: The author mentioned optical coherence tomography, confocal
endocroscopy. Please add the endocytoscopy (Dr.Kumagai et al.)
Line 20 on page 9
[The lesions diagnosed as cancer on NBI and the lesions diagnosed as HGIN or
cancer on biopsy were resected endoscopically or surgically]
= How many lesions were diagnosed as cancer on NBI?
How many lesions were diagnosed as undetermined on NBI, but cancer on
biopsy?
How many lesions were diagnosed cancer using iodine staining?
Please describe in detail.
Line 8 on page 13
The median size of tumor was 55mm?? Is it really? I think it too big. Please make
sure again.
# Line 7 on page 15 [Retrospective analysis of ten lesions misdiagnosed as no
cancer by endoscopic diagnosis was performed]
= Which categories does it belong to ‘undetermined’ or ‘no cancer’ on NBI.
# Line 4~6 on page 20
[Promising results~ multicenter study] : This is not a conclusion.
Please move the article to the discussion (limitation)
Reviewer's report
Title:Endoscopic optical diagnosis provides high diagnostic accuracy of
esophageal squamous cell carcinoma
Version:1Date:10 June 2014
Reviewer: kenro kawada
Reviewer's report:
Endoscopic optical diagnosis provides high diagnostic accuracy of esophageal
squamous cell carcinoma#
Thank you for allowing me the opportunity to review this manuscript. In this
study, the authors compared the accuracy of endoscopic and biopsy diagnosis. It
is believed that the gold standard of diagnosis is biopsy, but sometimes, there is
sampling error. The authors mentioned the usefulness of magnifying endoscopy
with NBI system. It is very interesting and useful, although it has some problems
to be solved before acceptance in its present form.
Minor revise
Major point
# The illustration [Figure 3,4,5,6,] does not match Figure Legend (Figure 3, 4a
4b, 4c,4d). please correct the mistake.
# Figure2 + Figure 3= Figure2??
The difference the accuracy between NBI with biopsy ?? please correct it.
# It is divided into three categories( Cancer, Undetermined, No cancer) of the
NBI diagnosis, please show the typical images each.
Minor point
Line 3 on page 6: The author mentioned optical coherence tomography, confocal
endocroscopy. Please add the endocytoscopy (Dr.Kumagai et al.)
Line 20 on page 9
[The lesions diagnosed as cancer on NBI and the lesions diagnosed as HGIN or
cancer on biopsy were resected endoscopically or surgically]
= How many lesions were diagnosed as cancer on NBI?
How many lesions were diagnosed as undetermined on NBI, but cancer on
biopsy?
How many lesions were diagnosed cancer using iodine staining?
Please describe in detail.
Line 8 on page 13
The median size of tumor was 55mm?? Is it really? I think it too big. Please make
sure again.
# Line 7 on page 15 [Retrospective analysis of ten lesions misdiagnosed as no
cancer by endoscopic diagnosis was performed]
= Which categories does it belong to ‘undetermined’ or ‘no cancer’ on NBI.
# Line 4~6 on page 20
[Promising results~ multicenter study] : This is not a conclusion.
Please move the article to the discussion (limitation)
Please review this paper.
user
Reviewer's report
Title:Endoscopic optical diagnosis provides high diagnostic accuracy of
esophageal squamous cell carcinoma
Version:1Date:10 June 2014
Reviewer: kenro kawada
Reviewer's report:
Endoscopic optical diagnosis provides high diagnostic accuracy of esophageal
squamous cell carcinoma#
Thank you for allowing me the opportunity to review this manuscript. In this
study, the authors compared the accuracy of endoscopic and biopsy diagnosis. It
is believed that the gold standard of diagnosis is biopsy, but sometimes, there is
sampling error. The authors mentioned the usefulness of magnifying endoscopy
with NBI system. It is very interesting and useful, although it has some problems
to be solved before acceptance in its present form.
Minor revise
Major point
# The illustration [Figure 3,4,5,6,] does not match Figure Legend (Figure 3, 4a
4b, 4c,4d). please correct the mistake.
# Figure2 + Figure 3= Figure2??
The difference the accuracy between NBI with biopsy ?? please correct it.
# It is divided into three categories( Cancer, Undetermined, No cancer) of the
NBI diagnosis, please show the typical images each.
Minor point
Line 3 on page 6: The author mentioned optical coherence tomography, confocal
endocroscopy. Please add the endocytoscopy (Dr.Kumagai et al.)
Line 20 on page 9
[The lesions diagnosed as cancer on NBI and the lesions diagnosed as HGIN or
cancer on biopsy were resected endoscopically or surgically]
= How many lesions were diagnosed as cancer on NBI?
How many lesions were diagnosed as undetermined on NBI, but cancer on
biopsy?
How many lesions were diagnosed cancer using iodine staining?
Please describe in detail.
Line 8 on page 13
The median size of tumor was 55mm?? Is it really? I think it too big. Please make
sure again.
# Line 7 on page 15 [Retrospective analysis of ten lesions misdiagnosed as no
cancer by endoscopic diagnosis was performed]
= Which categories does it belong to ‘undetermined’ or ‘no cancer’ on NBI.
# Line 4~6 on page 20
[Promising results~ multicenter study] : This is not a conclusion.
Please move the article to the discussion (limitation)
assistant