Reviewer's report
Title:Klebsiella pneumoniae bacteremia and renosplenic abscesses, without
intestinal symptoms, as the initial manifestations of non-steroidal
anti-inflammatory drug-induced colitis: a case report and literature review
Version: 5Date:25 June 2013
Reviewer: Giovanni Carini
Reviewer's report:
This is a case report of a disseminated infection by K.pneumoniae in a diabetic
patient with a supposed NSAID colitis.
- Major compulsory revisions: none.
- Minor essential revisions:
There is a typo error in the discussion (e.g. second paragraph: “The infection rate
increased…” instead of “increases”).
Some sentences in the discussion also need to be written in a better English (3rd
paragraph: “Intra-abdominal abscess…as in this case”; 6th paragraph
“Prostaglandins…immune system”).
-Discretionary revisions:
1) The authors could add some information about the clinical history of the
patient, such as the eventual concomitant use of other drugs than NSAIDs.
2) Have other forms of infectious colitis been ruled out, for instance by fecal
culture or colonic bioptic specimen culture/molecular biology exams? If yes,
authors could better clarify this point.
3) The lack of liver involvement is quite unusual given the hypothesis of bacterial
translocation from the colon as in this case. Have the authors considered the
possibility of other sources of infection (e.g. urinary tract) and, if not, what is their
opinion on the localization of the abscesses?
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Klebsiella pneumoniae bacteremia and renosplenic abscesses, without
intestinal symptoms, as the initial manifestations of non-steroidal
anti-inflammatory drug-induced colitis: a case report and literature review
Version: 5Date:25 June 2013
Reviewer: Giovanni Carini
Reviewer's report:
This is a case report of a disseminated infection by K.pneumoniae in a diabetic
patient with a supposed NSAID colitis.
- Major compulsory revisions: none.
- Minor essential revisions:
There is a typo error in the discussion (e.g. second paragraph: “The infection rate
increased…” instead of “increases”).
Some sentences in the discussion also need to be written in a better English (3rd
paragraph: “Intra-abdominal abscess…as in this case”; 6th paragraph
“Prostaglandins…immune system”).
-Discretionary revisions:
1) The authors could add some information about the clinical history of the
patient, such as the eventual concomitant use of other drugs than NSAIDs.
2) Have other forms of infectious colitis been ruled out, for instance by fecal
culture or colonic bioptic specimen culture/molecular biology exams? If yes,
authors could better clarify this point.
3) The lack of liver involvement is quite unusual given the hypothesis of bacterial
translocation from the colon as in this case. Have the authors considered the
possibility of other sources of infection (e.g. urinary tract) and, if not, what is their
opinion on the localization of the abscesses?
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Klebsiella pneumoniae bacteremia and renosplenic abscesses, without
intestinal symptoms, as the initial manifestations of non-steroidal
anti-inflammatory drug-induced colitis: a case report and literature review
Version: 5Date:25 June 2013
Reviewer: Giovanni Carini
Reviewer's report:
This is a case report of a disseminated infection by K.pneumoniae in a diabetic
patient with a supposed NSAID colitis.
- Major compulsory revisions: none.
- Minor essential revisions:
There is a typo error in the discussion (e.g. second paragraph: “The infection rate
increased…” instead of “increases”).
Some sentences in the discussion also need to be written in a better English (3rd
paragraph: “Intra-abdominal abscess…as in this case”; 6th paragraph
“Prostaglandins…immune system”).
-Discretionary revisions:
1) The authors could add some information about the clinical history of the
patient, such as the eventual concomitant use of other drugs than NSAIDs.
2) Have other forms of infectious colitis been ruled out, for instance by fecal
culture or colonic bioptic specimen culture/molecular biology exams? If yes,
authors could better clarify this point.
3) The lack of liver involvement is quite unusual given the hypothesis of bacterial
translocation from the colon as in this case. Have the authors considered the
possibility of other sources of infection (e.g. urinary tract) and, if not, what is their
opinion on the localization of the abscesses?
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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