Reviewer's report
Title:Antibodies against gonadotropin-releasing hormone (GnRH) and
destruction of enteric neurons in 3 patients suffering from gastrointestinal
dysfunction
Version: 1Date:5 June 2009
Reviewer: Jackie Wood
Reviewer's report:
This is a rather abbrevated report of three cases with functional gastrointestinal
disorders associated with enteric autoimmune degenerative neuropathy related
to circulating anti-enteric antibodies. It is groundbreaking and interesting for
interests in enteric neurophysiology, because mostly as yet unpublished
observations that high titers of anti-enteric antibodies are present in the serum of
an astonishly high proportion of patients with a Rome II/III symptom based
diagnosis of IBS. The data from the three patients was obtained with appropriate
and valid analytical methodologies and convincingly support the conclusion that
the patients' symptoms reflect degenerative loss of the enteric nervous system
(i.e., the brain-in-the-gut. The authors are congratulated for a well prepared
manuscript written in clear understandable English, with valid data that support
interpretations and conclusions.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Antibodies against gonadotropin-releasing hormone (GnRH) and
destruction of enteric neurons in 3 patients suffering from gastrointestinal
dysfunction
Version: 1Date:5 June 2009
Reviewer: Jackie Wood
Reviewer's report:
This is a rather abbrevated report of three cases with functional gastrointestinal
disorders associated with enteric autoimmune degenerative neuropathy related
to circulating anti-enteric antibodies. It is groundbreaking and interesting for
interests in enteric neurophysiology, because mostly as yet unpublished
observations that high titers of anti-enteric antibodies are present in the serum of
an astonishly high proportion of patients with a Rome II/III symptom based
diagnosis of IBS. The data from the three patients was obtained with appropriate
and valid analytical methodologies and convincingly support the conclusion that
the patients' symptoms reflect degenerative loss of the enteric nervous system
(i.e., the brain-in-the-gut. The authors are congratulated for a well prepared
manuscript written in clear understandable English, with valid data that support
interpretations and conclusions.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Antibodies against gonadotropin-releasing hormone (GnRH) and
destruction of enteric neurons in 3 patients suffering from gastrointestinal
dysfunction
Version: 1Date:5 June 2009
Reviewer: Jackie Wood
Reviewer's report:
This is a rather abbrevated report of three cases with functional gastrointestinal
disorders associated with enteric autoimmune degenerative neuropathy related
to circulating anti-enteric antibodies. It is groundbreaking and interesting for
interests in enteric neurophysiology, because mostly as yet unpublished
observations that high titers of anti-enteric antibodies are present in the serum of
an astonishly high proportion of patients with a Rome II/III symptom based
diagnosis of IBS. The data from the three patients was obtained with appropriate
and valid analytical methodologies and convincingly support the conclusion that
the patients' symptoms reflect degenerative loss of the enteric nervous system
(i.e., the brain-in-the-gut. The authors are congratulated for a well prepared
manuscript written in clear understandable English, with valid data that support
interpretations and conclusions.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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