Title: The clinical characteristics of focal acute pancreatitis based on imaging diagnosis:
comparison with non-localized acute pancreatitis- a preliminary result
Version: 2 Date: 25 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors raised an interesting clinical question related to
importance of focal pancreatitis. The study is retrospective, with the corresponding general
limitations.
REQUESTED REVISIONS:
The following comments may help improve the manuscript:
1. The laboratory diagnostic criteria for acute pancreatitis often include serum amylase or lipase
being at least 3 times above the upper reference limits. Please specify how many patients in each
group met this criterion for each pancreatic enzyme.
2. Please provide data on blood cancer biomarkers (e.g., CA 19-9) in the two groups. What
measures were taken to rule out premalignant pancreatic lesions (e.g., IPMN)?
3. Did the authors rule out autoimmune pancreatitis in the two groups?
4. Please specify in the methods section how exactly bloating and other symptoms were
diagnosed? Were the definitions standardized?
5. How many patients were transferred from another hospital?
6. How many patients required ICU admission?
7. Please specify at what point during hospitalization, CT was done? If there was more than 1
scan available for a give patient, which one was used?
8. Do the authors believe the diagnostic criteria for focal pancreatitis should be different from
non-localized pancreatitis?
Title: The clinical characteristics of focal acute pancreatitis based on imaging diagnosis:
comparison with non-localized acute pancreatitis- a preliminary result
Version: 2 Date: 25 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors raised an interesting clinical question related to
importance of focal pancreatitis. The study is retrospective, with the corresponding general
limitations.
REQUESTED REVISIONS:
The following comments may help improve the manuscript:
1. The laboratory diagnostic criteria for acute pancreatitis often include serum amylase or lipase
being at least 3 times above the upper reference limits. Please specify how many patients in each
group met this criterion for each pancreatic enzyme.
2. Please provide data on blood cancer biomarkers (e.g., CA 19-9) in the two groups. What
measures were taken to rule out premalignant pancreatic lesions (e.g., IPMN)?
3. Did the authors rule out autoimmune pancreatitis in the two groups?
4. Please specify in the methods section how exactly bloating and other symptoms were
diagnosed? Were the definitions standardized?
5. How many patients were transferred from another hospital?
6. How many patients required ICU admission?
7. Please specify at what point during hospitalization, CT was done? If there was more than 1
scan available for a give patient, which one was used?
8. Do the authors believe the diagnostic criteria for focal pancreatitis should be different from
non-localized pancreatitis?
Please review this paper.
user
Title: The clinical characteristics of focal acute pancreatitis based on imaging diagnosis:
comparison with non-localized acute pancreatitis- a preliminary result
Version: 2 Date: 25 Sep 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are minor issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors raised an interesting clinical question related to
importance of focal pancreatitis. The study is retrospective, with the corresponding general
limitations.
REQUESTED REVISIONS:
The following comments may help improve the manuscript:
1. The laboratory diagnostic criteria for acute pancreatitis often include serum amylase or lipase
being at least 3 times above the upper reference limits. Please specify how many patients in each
group met this criterion for each pancreatic enzyme.
2. Please provide data on blood cancer biomarkers (e.g., CA 19-9) in the two groups. What
measures were taken to rule out premalignant pancreatic lesions (e.g., IPMN)?
3. Did the authors rule out autoimmune pancreatitis in the two groups?
4. Please specify in the methods section how exactly bloating and other symptoms were
diagnosed? Were the definitions standardized?
5. How many patients were transferred from another hospital?
6. How many patients required ICU admission?
7. Please specify at what point during hospitalization, CT was done? If there was more than 1
scan available for a give patient, which one was used?
8. Do the authors believe the diagnostic criteria for focal pancreatitis should be different from
non-localized pancreatitis?
assistant