Title: Eradication therapy may decrease the risk of immune thrombocytopenia after
Helicobacter pylori infection: A retrospective cohort study in Taiwan
Version: 0 Date: 11 Dec 2022
Reviewer's report:
In this study the authors retrospectively analyzed the medical records of 1995 adult HP patients
over a 3-year period. After adjusting for other risk factors, the risk of ITP was compared between
patients with HPE and those without HPE. This study showed that adult patients with HP
infection not receiving HPE had a higher risk of developing ITP. There are some additional
points that should be covered prior to publication.
Specific Points
1. More information on which method the authors have used to treat HP and diagnosis of ITP
should be included in the manuscript (specific guidelines, consensus, etc.)
2. Are there any test results for HP in patients after HPE? If HP does not turn negative after
treatment, how to explain the findings of this study?
3. H pylori is recognized as a secondary cause of ITP and the infection may be directly involved
in the pathogenic process. The mechanism may relate to cross-reactive antibodies against platelet
antigens by molecular mimicry. If possible, IgG data from patients with/without HPE who
diagnosed with ITP should be added and analyzed.
4. Please explain the significance of the CCI index analyzed in the results.
Title: Eradication therapy may decrease the risk of immune thrombocytopenia after
Helicobacter pylori infection: A retrospective cohort study in Taiwan
Version: 0 Date: 11 Dec 2022
Reviewer's report:
In this study the authors retrospectively analyzed the medical records of 1995 adult HP patients
over a 3-year period. After adjusting for other risk factors, the risk of ITP was compared between
patients with HPE and those without HPE. This study showed that adult patients with HP
infection not receiving HPE had a higher risk of developing ITP. There are some additional
points that should be covered prior to publication.
Specific Points
1. More information on which method the authors have used to treat HP and diagnosis of ITP
should be included in the manuscript (specific guidelines, consensus, etc.)
2. Are there any test results for HP in patients after HPE? If HP does not turn negative after
treatment, how to explain the findings of this study?
3. H pylori is recognized as a secondary cause of ITP and the infection may be directly involved
in the pathogenic process. The mechanism may relate to cross-reactive antibodies against platelet
antigens by molecular mimicry. If possible, IgG data from patients with/without HPE who
diagnosed with ITP should be added and analyzed.
4. Please explain the significance of the CCI index analyzed in the results.
Please review this paper.
user
Title: Eradication therapy may decrease the risk of immune thrombocytopenia after
Helicobacter pylori infection: A retrospective cohort study in Taiwan
Version: 0 Date: 11 Dec 2022
Reviewer's report:
In this study the authors retrospectively analyzed the medical records of 1995 adult HP patients
over a 3-year period. After adjusting for other risk factors, the risk of ITP was compared between
patients with HPE and those without HPE. This study showed that adult patients with HP
infection not receiving HPE had a higher risk of developing ITP. There are some additional
points that should be covered prior to publication.
Specific Points
1. More information on which method the authors have used to treat HP and diagnosis of ITP
should be included in the manuscript (specific guidelines, consensus, etc.)
2. Are there any test results for HP in patients after HPE? If HP does not turn negative after
treatment, how to explain the findings of this study?
3. H pylori is recognized as a secondary cause of ITP and the infection may be directly involved
in the pathogenic process. The mechanism may relate to cross-reactive antibodies against platelet
antigens by molecular mimicry. If possible, IgG data from patients with/without HPE who
diagnosed with ITP should be added and analyzed.
4. Please explain the significance of the CCI index analyzed in the results.
assistant