Title: Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis
Version: 1 Date: 16 Oct 2024
Reviewer's report:
An interesting study evaluating the usefulness of fecal-calprotectin (FC) in UC patients with
inflammatory changes due to irreversible fibrosis is available at. Although the usefulness of F
C has already been established in UC patients, we report that FC is not predictive of recurrence
in all patients with mucosal healing.
However, I believe that this paper should be rejected for the following reasons.
1. As a single-center study, we believe that a multi-center, multifaceted evaluation is necessary
to assess the results fairly.
2. The definition of PEU is ambiguous. When accompanied by fibrilization, the assessment of
activity may be inconsistent.
3. I believe that the analysis should be compared with other inflammatory biomarker s such as
LRG and PG-MUM, which are commonly used in daily practice.
4. PEU itself is difficult to assess for activity, and furthermore, the result that even FC cannot
predict recurrence gives the impression that it is not clinically useful. In general, it would be
desirable to have a biomarker that can evaluate recurrence even in PEU.
Title: Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis
Version: 1 Date: 16 Oct 2024
Reviewer's report:
An interesting study evaluating the usefulness of fecal-calprotectin (FC) in UC patients with
inflammatory changes due to irreversible fibrosis is available at. Although the usefulness of F
C has already been established in UC patients, we report that FC is not predictive of recurrence
in all patients with mucosal healing.
However, I believe that this paper should be rejected for the following reasons.
1. As a single-center study, we believe that a multi-center, multifaceted evaluation is necessary
to assess the results fairly.
2. The definition of PEU is ambiguous. When accompanied by fibrilization, the assessment of
activity may be inconsistent.
3. I believe that the analysis should be compared with other inflammatory biomarker s such as
LRG and PG-MUM, which are commonly used in daily practice.
4. PEU itself is difficult to assess for activity, and furthermore, the result that even FC cannot
predict recurrence gives the impression that it is not clinically useful. In general, it would be
desirable to have a biomarker that can evaluate recurrence even in PEU.
Please review this paper.
user
Title: Effect of past extensive ulcers on fecal calprotectin in ulcerative colitis
Version: 1 Date: 16 Oct 2024
Reviewer's report:
An interesting study evaluating the usefulness of fecal-calprotectin (FC) in UC patients with
inflammatory changes due to irreversible fibrosis is available at. Although the usefulness of F
C has already been established in UC patients, we report that FC is not predictive of recurrence
in all patients with mucosal healing.
However, I believe that this paper should be rejected for the following reasons.
1. As a single-center study, we believe that a multi-center, multifaceted evaluation is necessary
to assess the results fairly.
2. The definition of PEU is ambiguous. When accompanied by fibrilization, the assessment of
activity may be inconsistent.
3. I believe that the analysis should be compared with other inflammatory biomarker s such as
LRG and PG-MUM, which are commonly used in daily practice.
4. PEU itself is difficult to assess for activity, and furthermore, the result that even FC cannot
predict recurrence gives the impression that it is not clinically useful. In general, it would be
desirable to have a biomarker that can evaluate recurrence even in PEU.
assistant