Reviewer's report
Title:Analysis of cell cycle-related proteins in gastric intramucosal
differentiated-type cancers based on mucin phenotypes: a new concept of
molecular carcinogenesis for early differentiated-type gastric cancers
Version: 1Date:15 November 2009
Reviewer: Masashi Fukayama
Reviewer's report:
Major revisions
1. The authors should tone down the title, since their results are not decisive
enough to propose the new concept of molecular carcinogenesis.
2. As the authors themselves admitted, it is more meaningful to use an absolute
rate (i.e., the actual %), rather than this internal relative value.
3. The CDX2 immunohistochemistry is not necessary in this study. The results
were not helpful, or even confusing, for the understanding the mucin phenotypes,
which the authors proposed as the classification of intramucosal differentiated
gastric carcinoma.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Analysis of cell cycle-related proteins in gastric intramucosal
differentiated-type cancers based on mucin phenotypes: a new concept of
molecular carcinogenesis for early differentiated-type gastric cancers
Version: 1Date:15 November 2009
Reviewer: Masashi Fukayama
Reviewer's report:
Major revisions
1. The authors should tone down the title, since their results are not decisive
enough to propose the new concept of molecular carcinogenesis.
2. As the authors themselves admitted, it is more meaningful to use an absolute
rate (i.e., the actual %), rather than this internal relative value.
3. The CDX2 immunohistochemistry is not necessary in this study. The results
were not helpful, or even confusing, for the understanding the mucin phenotypes,
which the authors proposed as the classification of intramucosal differentiated
gastric carcinoma.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Analysis of cell cycle-related proteins in gastric intramucosal
differentiated-type cancers based on mucin phenotypes: a new concept of
molecular carcinogenesis for early differentiated-type gastric cancers
Version: 1Date:15 November 2009
Reviewer: Masashi Fukayama
Reviewer's report:
Major revisions
1. The authors should tone down the title, since their results are not decisive
enough to propose the new concept of molecular carcinogenesis.
2. As the authors themselves admitted, it is more meaningful to use an absolute
rate (i.e., the actual %), rather than this internal relative value.
3. The CDX2 immunohistochemistry is not necessary in this study. The results
were not helpful, or even confusing, for the understanding the mucin phenotypes,
which the authors proposed as the classification of intramucosal differentiated
gastric carcinoma.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant