Title: Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R -/- mice
Version: 6 Date: 11 Jul 2023
Reviewer's report:
Firstly, thanks for your response.
1- My suggestion is to add words about methodology in key words section that is attractive to
readers.
2- I suggest continuing the idea of this research on normal animals.
3- In the materials and methods section, you added a part about Hematoxylin and eosin staining,
please revise this part because the anesthetic substance name is different as well as remove the
heart word.
4- In the result section: why did you show the histological figures in a small size, for that the
changes are unclear, especially in HD group.  Also, you added arrows but did not demonstrate
the type of changes. You can put arrows with different colors or put small letters on the changes
then write about that below the figures.
5- What is the method or program that you applied to obtain the percentage of CD68+.
Title: Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R -/- mice
Version: 6 Date: 11 Jul 2023
Reviewer's report:
Firstly, thanks for your response.
1- My suggestion is to add words about methodology in key words section that is attractive to
readers.
2- I suggest continuing the idea of this research on normal animals.
3- In the materials and methods section, you added a part about Hematoxylin and eosin staining,
please revise this part because the anesthetic substance name is different as well as remove the
heart word.
4- In the result section: why did you show the histological figures in a small size, for that the
changes are unclear, especially in HD group.  Also, you added arrows but did not demonstrate
the type of changes. You can put arrows with different colors or put small letters on the changes
then write about that below the figures.
5- What is the method or program that you applied to obtain the percentage of CD68+.
Please review this paper.
user
Title: Protective role of thymoquinone in hyperlipidemia-induced liver injury in LDL-R -/- mice
Version: 6 Date: 11 Jul 2023
Reviewer's report:
Firstly, thanks for your response.
1- My suggestion is to add words about methodology in key words section that is attractive to
readers.
2- I suggest continuing the idea of this research on normal animals.
3- In the materials and methods section, you added a part about Hematoxylin and eosin staining,
please revise this part because the anesthetic substance name is different as well as remove the
heart word.
4- In the result section: why did you show the histological figures in a small size, for that the
changes are unclear, especially in HD group.  Also, you added arrows but did not demonstrate
the type of changes. You can put arrows with different colors or put small letters on the changes
then write about that below the figures.
5- What is the method or program that you applied to obtain the percentage of CD68+.
assistant