Reviewer’s report
Title: 
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a
tricky diagnosis of a gastric case
Version: 
1 
Date: 
15 Sep 2020
Reviewer's report:
The authors illustrate and interesting case of ITLPD of the GI tract occurring in
the stomach of a young woman. The report is brief and overall well written and
illustrated. I have a few minor suggestions. 1) The language could be improved a
bit. Review by a native English speaker could 
help, 2) I am not aware of word
count constraints, but the the method used for TCR-g gene rearrangement should
be mentioned. You could state PCR analysis for TCR-g gene rearrangement was
performed according to the method of XYZ et al and provide the reference, 3)
This case occurred in a young woman and involved the stomach and bone
marrow. These points should be emphasized in the abstract and discussion, since
ITLPD generally is a disease of older adults, occurring in the intestines, and
dissemination to other organs has not been emphasized enough, 4) How s disease
excluded in other parts of the GI tract? Clearly imaging and scans are
insufficient. Should mention if other biopsies were reviewed and
immunohistochemistry and molecular analysis were performed , with the results.
This is important as disease infiltration can be subtle in other GI organs. If these
studies were not performed, at least TCR-g gene rearrangement analysis should
be performed on biopsies from other sites to rule out the possibility of wider
dissemination, 5) Lastly, there have been recent advances in understanding the
molecular abnormalities in ITLPDs, the authors could mention recurrent genetic
alterations briefly (one or two sentences) with the appropriate references.
Publons Reviewer Recognition
. Springer Nature can send verification of this
review directly to Publons (a subsidiary of Clarivate Analytics). If you would
like to take advantage of this service, please click on the “Yes” option below.
Your name, email address, title of the reviewed manuscript, name of the journal,
and date of your review submission (the “Review Data”) will then be transmitted
to Publons upon publication of the manuscript. If you have already registered at
Publons, they will notify you of the receipt of this review and update your profile
as per your settings and their policy. If you are not registered with Publons, you
will receive an email from them asking you to register in order for them to be
able to recognize your review on your new profile page. Publons may use the
Review Data to generate derivative metadata for the benefit of Publons and you
as a reviewer, carefully considering the sensitivity of such information. For
example, Publons may verify your record as a reviewer by updating your profile
published on its webservice if you have registered for such service or help
editors to identify candidate reviewers. Please find the details of processing in
Publons’ privacy policy 
https://publons.com/about/terms
No
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name
with my report. (default)
Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
Reviewer’s report
Title: 
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a
tricky diagnosis of a gastric case
Version: 
1 
Date: 
15 Sep 2020
Reviewer's report:
The authors illustrate and interesting case of ITLPD of the GI tract occurring in
the stomach of a young woman. The report is brief and overall well written and
illustrated. I have a few minor suggestions. 1) The language could be improved a
bit. Review by a native English speaker could 
help, 2) I am not aware of word
count constraints, but the the method used for TCR-g gene rearrangement should
be mentioned. You could state PCR analysis for TCR-g gene rearrangement was
performed according to the method of XYZ et al and provide the reference, 3)
This case occurred in a young woman and involved the stomach and bone
marrow. These points should be emphasized in the abstract and discussion, since
ITLPD generally is a disease of older adults, occurring in the intestines, and
dissemination to other organs has not been emphasized enough, 4) How s disease
excluded in other parts of the GI tract? Clearly imaging and scans are
insufficient. Should mention if other biopsies were reviewed and
immunohistochemistry and molecular analysis were performed , with the results.
This is important as disease infiltration can be subtle in other GI organs. If these
studies were not performed, at least TCR-g gene rearrangement analysis should
be performed on biopsies from other sites to rule out the possibility of wider
dissemination, 5) Lastly, there have been recent advances in understanding the
molecular abnormalities in ITLPDs, the authors could mention recurrent genetic
alterations briefly (one or two sentences) with the appropriate references.
Publons Reviewer Recognition
. Springer Nature can send verification of this
review directly to Publons (a subsidiary of Clarivate Analytics). If you would
like to take advantage of this service, please click on the “Yes” option below.
Your name, email address, title of the reviewed manuscript, name of the journal,
and date of your review submission (the “Review Data”) will then be transmitted
to Publons upon publication of the manuscript. If you have already registered at
Publons, they will notify you of the receipt of this review and update your profile
as per your settings and their policy. If you are not registered with Publons, you
will receive an email from them asking you to register in order for them to be
able to recognize your review on your new profile page. Publons may use the
Review Data to generate derivative metadata for the benefit of Publons and you
as a reviewer, carefully considering the sensitivity of such information. For
example, Publons may verify your record as a reviewer by updating your profile
published on its webservice if you have registered for such service or help
editors to identify candidate reviewers. Please find the details of processing in
Publons’ privacy policy 
https://publons.com/about/terms
No
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name
with my report. (default)
Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
Please review this paper.
user
Reviewer’s report
Title: 
Indolent T-cell lymphoproliferative disorder of the gastrointestinal tract: a
tricky diagnosis of a gastric case
Version: 
1 
Date: 
15 Sep 2020
Reviewer's report:
The authors illustrate and interesting case of ITLPD of the GI tract occurring in
the stomach of a young woman. The report is brief and overall well written and
illustrated. I have a few minor suggestions. 1) The language could be improved a
bit. Review by a native English speaker could 
help, 2) I am not aware of word
count constraints, but the the method used for TCR-g gene rearrangement should
be mentioned. You could state PCR analysis for TCR-g gene rearrangement was
performed according to the method of XYZ et al and provide the reference, 3)
This case occurred in a young woman and involved the stomach and bone
marrow. These points should be emphasized in the abstract and discussion, since
ITLPD generally is a disease of older adults, occurring in the intestines, and
dissemination to other organs has not been emphasized enough, 4) How s disease
excluded in other parts of the GI tract? Clearly imaging and scans are
insufficient. Should mention if other biopsies were reviewed and
immunohistochemistry and molecular analysis were performed , with the results.
This is important as disease infiltration can be subtle in other GI organs. If these
studies were not performed, at least TCR-g gene rearrangement analysis should
be performed on biopsies from other sites to rule out the possibility of wider
dissemination, 5) Lastly, there have been recent advances in understanding the
molecular abnormalities in ITLPDs, the authors could mention recurrent genetic
alterations briefly (one or two sentences) with the appropriate references.
Publons Reviewer Recognition
. Springer Nature can send verification of this
review directly to Publons (a subsidiary of Clarivate Analytics). If you would
like to take advantage of this service, please click on the “Yes” option below.
Your name, email address, title of the reviewed manuscript, name of the journal,
and date of your review submission (the “Review Data”) will then be transmitted
to Publons upon publication of the manuscript. If you have already registered at
Publons, they will notify you of the receipt of this review and update your profile
as per your settings and their policy. If you are not registered with Publons, you
will receive an email from them asking you to register in order for them to be
able to recognize your review on your new profile page. Publons may use the
Review Data to generate derivative metadata for the benefit of Publons and you
as a reviewer, carefully considering the sensitivity of such information. For
example, Publons may verify your record as a reviewer by updating your profile
published on its webservice if you have registered for such service or help
editors to identify candidate reviewers. Please find the details of processing in
Publons’ privacy policy 
https://publons.com/about/terms
No
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name
with my report. (default)
Is the study design appropriate to answer the research question (including the use
of appropriate controls), and are the conclusions supported by the evidence
presented?
Yes
Are the methods sufficiently described to allow the study to be repeated?
No
Is the use of statistics and treatment of uncertainties appropriate?
Yes
Is the presentation of the work clear?
Yes
Are the images in this manuscript (including electrophoretic gels and blots) free
from apparent manipulation?
Yes
assistant