Title: Long-term outcomes of endoscopic submucosal dissection for superficial esophageal
squamous cell carcinoma in Taiwan
Version: 3 Date: 03 May 2021
Reviewer's report:
This is a retrospective study to assess the long-term outcomes of endoscopic submucosal
dissection (ESD) for esophageal squamous cell carcinoma (SCC) in Taiwan. The clinical
question is important. However, this study has some limitations. My main issues are as follows.
Please show not only disease specific survival but also overall survival of patients, because other
organ cancer is very important for patients with esophageal SCC.
In this study, 17.4% of cancers were invading into the submucosa. Please show additional
treatments for patients with non-curative resection.
Please summarize breakdown of metastatic recurrence.
Please also summarize stage of metachronous esophageal SCC and their treatment.
In this study, approximately 60% of patients had head and neck cancers. What are the risk factors
for head and neck cancers in this study (drinking, multiple LVLs, or betel nuts)?
Minor point.
In the result, there is a description as follows “The mean tumor size was 32.8 ± 16.9 cm”.
However, it should be “The mean tumor size was 32.8 ± 16.9 mm”.
Title: Long-term outcomes of endoscopic submucosal dissection for superficial esophageal
squamous cell carcinoma in Taiwan
Version: 3 Date: 03 May 2021
Reviewer's report:
This is a retrospective study to assess the long-term outcomes of endoscopic submucosal
dissection (ESD) for esophageal squamous cell carcinoma (SCC) in Taiwan. The clinical
question is important. However, this study has some limitations. My main issues are as follows.
Please show not only disease specific survival but also overall survival of patients, because other
organ cancer is very important for patients with esophageal SCC.
In this study, 17.4% of cancers were invading into the submucosa. Please show additional
treatments for patients with non-curative resection.
Please summarize breakdown of metastatic recurrence.
Please also summarize stage of metachronous esophageal SCC and their treatment.
In this study, approximately 60% of patients had head and neck cancers. What are the risk factors
for head and neck cancers in this study (drinking, multiple LVLs, or betel nuts)?
Minor point.
In the result, there is a description as follows “The mean tumor size was 32.8 ± 16.9 cm”.
However, it should be “The mean tumor size was 32.8 ± 16.9 mm”.
Please review this paper.
user
Title: Long-term outcomes of endoscopic submucosal dissection for superficial esophageal
squamous cell carcinoma in Taiwan
Version: 3 Date: 03 May 2021
Reviewer's report:
This is a retrospective study to assess the long-term outcomes of endoscopic submucosal
dissection (ESD) for esophageal squamous cell carcinoma (SCC) in Taiwan. The clinical
question is important. However, this study has some limitations. My main issues are as follows.
Please show not only disease specific survival but also overall survival of patients, because other
organ cancer is very important for patients with esophageal SCC.
In this study, 17.4% of cancers were invading into the submucosa. Please show additional
treatments for patients with non-curative resection.
Please summarize breakdown of metastatic recurrence.
Please also summarize stage of metachronous esophageal SCC and their treatment.
In this study, approximately 60% of patients had head and neck cancers. What are the risk factors
for head and neck cancers in this study (drinking, multiple LVLs, or betel nuts)?
Minor point.
In the result, there is a description as follows “The mean tumor size was 32.8 ± 16.9 cm”.
However, it should be “The mean tumor size was 32.8 ± 16.9 mm”.
assistant