Title: Fructose malabsorption and fructan malabsorption are associated in patients with irritable
bowel syndrome
Version: 4 Date: 29 Mar 2024
Reviewer:  Danilo Consalvo
Reviewer's report:
the topic is really interesting!
I would suggest an introduction more in line with the title: it should start from the main pathology
IBS and then move on to the description of FODMAPs and finally fructose and fructan and their
intolerance.
The exclusion of SIBO should be better commented on in the methods, as this reduces the
percentage of patients suffering from IBS. The overlap between IBS and SIBO is known.
Otherwise it can be added in the title that it is IBS with the exclusion of patients suffering from
SIBO.
Figure 2 is confusing, it should be simplified by illustrating two pie charts, one of which concerns
positive fructan tests and one with negative fructan tests.
Title: Fructose malabsorption and fructan malabsorption are associated in patients with irritable
bowel syndrome
Version: 4 Date: 29 Mar 2024
Reviewer:  Danilo Consalvo
Reviewer's report:
the topic is really interesting!
I would suggest an introduction more in line with the title: it should start from the main pathology
IBS and then move on to the description of FODMAPs and finally fructose and fructan and their
intolerance.
The exclusion of SIBO should be better commented on in the methods, as this reduces the
percentage of patients suffering from IBS. The overlap between IBS and SIBO is known.
Otherwise it can be added in the title that it is IBS with the exclusion of patients suffering from
SIBO.
Figure 2 is confusing, it should be simplified by illustrating two pie charts, one of which concerns
positive fructan tests and one with negative fructan tests.
Please review this paper.
user
Title: Fructose malabsorption and fructan malabsorption are associated in patients with irritable
bowel syndrome
Version: 4 Date: 29 Mar 2024
Reviewer:  Danilo Consalvo
Reviewer's report:
the topic is really interesting!
I would suggest an introduction more in line with the title: it should start from the main pathology
IBS and then move on to the description of FODMAPs and finally fructose and fructan and their
intolerance.
The exclusion of SIBO should be better commented on in the methods, as this reduces the
percentage of patients suffering from IBS. The overlap between IBS and SIBO is known.
Otherwise it can be added in the title that it is IBS with the exclusion of patients suffering from
SIBO.
Figure 2 is confusing, it should be simplified by illustrating two pie charts, one of which concerns
positive fructan tests and one with negative fructan tests.
assistant