Title: Ultrasound imaging findings in primary biliary cholangitis
Version: 3 Date: 19 Nov 2023
Reviewer's report:
Very specific topic, but relevant for internal medicine and hepatology diagnostics.
Relatively large number of PBC patients.
Confirmed by histology and comparison with Hep B patients.
First assessment of fibrosis grade by US criteria in PBC patients.
Very positive: 2 very experienced investigators were blinded.
Included patients were evenly distributed in 4 histological stages
Introduction: Backround and aim of the study are clearly stated and understandable
Methods: Well understood
Results: factual comparison. Interobserver agreemant is also described
Discussion: Very extensive but understandable.
Topic Limitations: Is an application also recommended for less experienced ultrasonographers?
Probably not? Because the sonography method is very
special and requires a large routine, therefore a generalization is only possible with limitations.
Summary: A very nice, clearly conducted study with valid and for the first time so described
results.
Only in the limitation the above-mentioned addition would have to be made, with 2 or maximum
3 sentences to be inserte
Title: Ultrasound imaging findings in primary biliary cholangitis
Version: 3 Date: 19 Nov 2023
Reviewer's report:
Very specific topic, but relevant for internal medicine and hepatology diagnostics.
Relatively large number of PBC patients.
Confirmed by histology and comparison with Hep B patients.
First assessment of fibrosis grade by US criteria in PBC patients.
Very positive: 2 very experienced investigators were blinded.
Included patients were evenly distributed in 4 histological stages
Introduction: Backround and aim of the study are clearly stated and understandable
Methods: Well understood
Results: factual comparison. Interobserver agreemant is also described
Discussion: Very extensive but understandable.
Topic Limitations: Is an application also recommended for less experienced ultrasonographers?
Probably not? Because the sonography method is very
special and requires a large routine, therefore a generalization is only possible with limitations.
Summary: A very nice, clearly conducted study with valid and for the first time so described
results.
Only in the limitation the above-mentioned addition would have to be made, with 2 or maximum
3 sentences to be inserte
Please review this paper.
user
Title: Ultrasound imaging findings in primary biliary cholangitis
Version: 3 Date: 19 Nov 2023
Reviewer's report:
Very specific topic, but relevant for internal medicine and hepatology diagnostics.
Relatively large number of PBC patients.
Confirmed by histology and comparison with Hep B patients.
First assessment of fibrosis grade by US criteria in PBC patients.
Very positive: 2 very experienced investigators were blinded.
Included patients were evenly distributed in 4 histological stages
Introduction: Backround and aim of the study are clearly stated and understandable
Methods: Well understood
Results: factual comparison. Interobserver agreemant is also described
Discussion: Very extensive but understandable.
Topic Limitations: Is an application also recommended for less experienced ultrasonographers?
Probably not? Because the sonography method is very
special and requires a large routine, therefore a generalization is only possible with limitations.
Summary: A very nice, clearly conducted study with valid and for the first time so described
results.
Only in the limitation the above-mentioned addition would have to be made, with 2 or maximum
3 sentences to be inserte
assistant