Reviewer's report
Title:Evaluation the Hepa Wash(R) treatment in pigs with acute liver failure
Version: 2Date:4 March 2013
Reviewer: Faouzi Saliba
Reviewer's report:
Major Compulsory revision
1_ In abstracts. The data provided on MARS treatment in pigs are very limited
(n=2) and data collected after the MARS therapy and prior and time of animal
death are very difficult to interprete. In addition, they are discordant with the
animal studies reported in the litterature. Therefore, we recommend to delete the
last sentence in the abstract: Surprisingly, animals treated with MARS.....
2- Adding the results on ICP in the abstracts could be important for the readers.
This would highlight better the message of improved cerebral perfusion pressure
was related to improvement in systemic hemodynamics.
3- In Discussion, page 16. The authors should comment more on the animal
models used for MARS and Prometheus and what differ to their model in order to
have discordance on ICP pressure
4- In Results : Page 14. The results of the MARS procedure on survival could be
incorporated also in the survival section of all animals groups page 12.
5- Figure 6 should be deleted as do not bring additional information (see also
comment N°1.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have received speaker fees from Gambro.
Reviewer's report
Title:Evaluation the Hepa Wash(R) treatment in pigs with acute liver failure
Version: 2Date:4 March 2013
Reviewer: Faouzi Saliba
Reviewer's report:
Major Compulsory revision
1_ In abstracts. The data provided on MARS treatment in pigs are very limited
(n=2) and data collected after the MARS therapy and prior and time of animal
death are very difficult to interprete. In addition, they are discordant with the
animal studies reported in the litterature. Therefore, we recommend to delete the
last sentence in the abstract: Surprisingly, animals treated with MARS.....
2- Adding the results on ICP in the abstracts could be important for the readers.
This would highlight better the message of improved cerebral perfusion pressure
was related to improvement in systemic hemodynamics.
3- In Discussion, page 16. The authors should comment more on the animal
models used for MARS and Prometheus and what differ to their model in order to
have discordance on ICP pressure
4- In Results : Page 14. The results of the MARS procedure on survival could be
incorporated also in the survival section of all animals groups page 12.
5- Figure 6 should be deleted as do not bring additional information (see also
comment N°1.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have received speaker fees from Gambro.
Please review this paper.
user
Reviewer's report
Title:Evaluation the Hepa Wash(R) treatment in pigs with acute liver failure
Version: 2Date:4 March 2013
Reviewer: Faouzi Saliba
Reviewer's report:
Major Compulsory revision
1_ In abstracts. The data provided on MARS treatment in pigs are very limited
(n=2) and data collected after the MARS therapy and prior and time of animal
death are very difficult to interprete. In addition, they are discordant with the
animal studies reported in the litterature. Therefore, we recommend to delete the
last sentence in the abstract: Surprisingly, animals treated with MARS.....
2- Adding the results on ICP in the abstracts could be important for the readers.
This would highlight better the message of improved cerebral perfusion pressure
was related to improvement in systemic hemodynamics.
3- In Discussion, page 16. The authors should comment more on the animal
models used for MARS and Prometheus and what differ to their model in order to
have discordance on ICP pressure
4- In Results : Page 14. The results of the MARS procedure on survival could be
incorporated also in the survival section of all animals groups page 12.
5- Figure 6 should be deleted as do not bring additional information (see also
comment N°1.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have received speaker fees from Gambro.
assistant