Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 1 Date: 04 Nov 2023
Reviewer's report:
Dear Authors,
Thanks for preparing these study. I read the manuscript , and I found some point that not
reasonable including:
1- Would you please inform me about a citation for definition of the patients under the stable
versus unstable CC treatment.
2-Majority of the patients were in the geriatric group with some comorbidity, did you considered
this confounding factors? Because the gut flora is so different in this age group.
3- Table of baseline clinical data-1  shows that 12 stable CC treatment patients received 3 or
more types of laxative. This is not matched with the definition?
4- At discussion; you concluded that usage of acid suppressing agents could preserve stability
in treatment. Which acid lowering agent? How long a patient has taken that? Would you please
explain about that, because we know that acid lowering agents should be prescribed short time
in the FD /GERD  relief.
5- Would you please updated the references.
Finally, I think the manuscript need major revision, if possible.
Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 1 Date: 04 Nov 2023
Reviewer's report:
Dear Authors,
Thanks for preparing these study. I read the manuscript , and I found some point that not
reasonable including:
1- Would you please inform me about a citation for definition of the patients under the stable
versus unstable CC treatment.
2-Majority of the patients were in the geriatric group with some comorbidity, did you considered
this confounding factors? Because the gut flora is so different in this age group.
3- Table of baseline clinical data-1  shows that 12 stable CC treatment patients received 3 or
more types of laxative. This is not matched with the definition?
4- At discussion; you concluded that usage of acid suppressing agents could preserve stability
in treatment. Which acid lowering agent? How long a patient has taken that? Would you please
explain about that, because we know that acid lowering agents should be prescribed short time
in the FD /GERD  relief.
5- Would you please updated the references.
Finally, I think the manuscript need major revision, if possible.
Please review this paper.
user
Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 1 Date: 04 Nov 2023
Reviewer's report:
Dear Authors,
Thanks for preparing these study. I read the manuscript , and I found some point that not
reasonable including:
1- Would you please inform me about a citation for definition of the patients under the stable
versus unstable CC treatment.
2-Majority of the patients were in the geriatric group with some comorbidity, did you considered
this confounding factors? Because the gut flora is so different in this age group.
3- Table of baseline clinical data-1  shows that 12 stable CC treatment patients received 3 or
more types of laxative. This is not matched with the definition?
4- At discussion; you concluded that usage of acid suppressing agents could preserve stability
in treatment. Which acid lowering agent? How long a patient has taken that? Would you please
explain about that, because we know that acid lowering agents should be prescribed short time
in the FD /GERD  relief.
5- Would you please updated the references.
Finally, I think the manuscript need major revision, if possible.
assistant