Title: Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem
cell transplantation
Version: 0 Date: 18 Jan 2024
Reviewer's report:
This manuscript explored the endoscopic characteristics of patients diagnosed with iTAM.
Among 14 iTAM patients, endoscopic manifestations included reddish mucosa (n = 14),
erosions (n = 13), ulcers (n = 9), mucosal edema (n = 9), granular mucosa (n = 9), and villous
atrophy (n = 4). Erosions and/or ulcers were primarily observed in the colon (10/14, 71.4%),
followed by the ileum (9/13, 69.2%), stomach (4/10, 40.0%), cecum (5/14, 35.7%), duodenum
(3/10, 30.0%), rectum (4/14, 28.6%), and esophagus (1/10, 10.0%). The results were quite
interesting. However, they need to answer the following questions.
1. They identified 14 patients (9 men and 5 women) diagnosed with iTAM between May 2015
and April 2023. If they know how often this occurs, please let us know.
2. It is difficult to understand the specific endoscopic features of iTAMs compared with
cytomegalovirus or GVHD. Can we diagnose the iTAM by the endoscopic observation?
3. They determined serological markers for diagnosing iTAM. What are the specific markers
or useful tools for the diagnosis.
4. Various endoscopic findings are shown, but is it possible to classify the severity? Also, is it
possible to show the relationship between its severity, blood markers, and even prognosis?
5. Please provide how to diagnose CMV infection.
Title: Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem
cell transplantation
Version: 0 Date: 18 Jan 2024
Reviewer's report:
This manuscript explored the endoscopic characteristics of patients diagnosed with iTAM.
Among 14 iTAM patients, endoscopic manifestations included reddish mucosa (n = 14),
erosions (n = 13), ulcers (n = 9), mucosal edema (n = 9), granular mucosa (n = 9), and villous
atrophy (n = 4). Erosions and/or ulcers were primarily observed in the colon (10/14, 71.4%),
followed by the ileum (9/13, 69.2%), stomach (4/10, 40.0%), cecum (5/14, 35.7%), duodenum
(3/10, 30.0%), rectum (4/14, 28.6%), and esophagus (1/10, 10.0%). The results were quite
interesting. However, they need to answer the following questions.
1. They identified 14 patients (9 men and 5 women) diagnosed with iTAM between May 2015
and April 2023. If they know how often this occurs, please let us know.
2. It is difficult to understand the specific endoscopic features of iTAMs compared with
cytomegalovirus or GVHD. Can we diagnose the iTAM by the endoscopic observation?
3. They determined serological markers for diagnosing iTAM. What are the specific markers
or useful tools for the diagnosis.
4. Various endoscopic findings are shown, but is it possible to classify the severity? Also, is it
possible to show the relationship between its severity, blood markers, and even prognosis?
5. Please provide how to diagnose CMV infection.
Please review this paper.
user
Title: Endoscopic manifestation of intestinal transplant-associated microangiopathy after stem
cell transplantation
Version: 0 Date: 18 Jan 2024
Reviewer's report:
This manuscript explored the endoscopic characteristics of patients diagnosed with iTAM.
Among 14 iTAM patients, endoscopic manifestations included reddish mucosa (n = 14),
erosions (n = 13), ulcers (n = 9), mucosal edema (n = 9), granular mucosa (n = 9), and villous
atrophy (n = 4). Erosions and/or ulcers were primarily observed in the colon (10/14, 71.4%),
followed by the ileum (9/13, 69.2%), stomach (4/10, 40.0%), cecum (5/14, 35.7%), duodenum
(3/10, 30.0%), rectum (4/14, 28.6%), and esophagus (1/10, 10.0%). The results were quite
interesting. However, they need to answer the following questions.
1. They identified 14 patients (9 men and 5 women) diagnosed with iTAM between May 2015
and April 2023. If they know how often this occurs, please let us know.
2. It is difficult to understand the specific endoscopic features of iTAMs compared with
cytomegalovirus or GVHD. Can we diagnose the iTAM by the endoscopic observation?
3. They determined serological markers for diagnosing iTAM. What are the specific markers
or useful tools for the diagnosis.
4. Various endoscopic findings are shown, but is it possible to classify the severity? Also, is it
possible to show the relationship between its severity, blood markers, and even prognosis?
5. Please provide how to diagnose CMV infection.
assistant