Title: Efficacy of endoscopic submucosal resection with a ligation device for small rectal
neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial
(BANDIT trial)
Version: 1 Date: 29 Oct 2023
Reviewer:  Kenjiro Shigita
Reviewer's report:
I would like to express my gratitude for the opportunity to review the research protocol submitted
to BMC Gastroenterology. After carefully examining the research protocol, I am pleased to
report that I find the following four points to be acceptable:
The study design appears to be well-suited to test the hypothesis. The research is described as a
prospective, open-label, multicenter, non-inferiority, randomized controlled trial of two parallel
groups, and it seems to have been adequately validated.
The authors have provided sufficient details that enable the replication of the work or comparison
with related analyses. Notably, the methodology ensures that differences in physician skills
do not affect the comparison of treatment methods, and random assignment was designed to
minimize bias by randomizing both by facility and physician proficiency factor.
The planned statistical analysis is appropriate, and the sample size appears to be adequately
determined for the study.
The quality of writing in the research protocol is acceptable.
Overall, the research protocol demonstrates a strong foundation for further examination and
contribution to the field of gastroenterology. I would recommend this paper for publication, with
minor revisions and clarifications as needed.
Title: Efficacy of endoscopic submucosal resection with a ligation device for small rectal
neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial
(BANDIT trial)
Version: 1 Date: 29 Oct 2023
Reviewer:  Kenjiro Shigita
Reviewer's report:
I would like to express my gratitude for the opportunity to review the research protocol submitted
to BMC Gastroenterology. After carefully examining the research protocol, I am pleased to
report that I find the following four points to be acceptable:
The study design appears to be well-suited to test the hypothesis. The research is described as a
prospective, open-label, multicenter, non-inferiority, randomized controlled trial of two parallel
groups, and it seems to have been adequately validated.
The authors have provided sufficient details that enable the replication of the work or comparison
with related analyses. Notably, the methodology ensures that differences in physician skills
do not affect the comparison of treatment methods, and random assignment was designed to
minimize bias by randomizing both by facility and physician proficiency factor.
The planned statistical analysis is appropriate, and the sample size appears to be adequately
determined for the study.
The quality of writing in the research protocol is acceptable.
Overall, the research protocol demonstrates a strong foundation for further examination and
contribution to the field of gastroenterology. I would recommend this paper for publication, with
minor revisions and clarifications as needed.
Please review this paper.
user
Title: Efficacy of endoscopic submucosal resection with a ligation device for small rectal
neuroendocrine tumor: study protocol of a multicenter open-label randomized control trial
(BANDIT trial)
Version: 1 Date: 29 Oct 2023
Reviewer:  Kenjiro Shigita
Reviewer's report:
I would like to express my gratitude for the opportunity to review the research protocol submitted
to BMC Gastroenterology. After carefully examining the research protocol, I am pleased to
report that I find the following four points to be acceptable:
The study design appears to be well-suited to test the hypothesis. The research is described as a
prospective, open-label, multicenter, non-inferiority, randomized controlled trial of two parallel
groups, and it seems to have been adequately validated.
The authors have provided sufficient details that enable the replication of the work or comparison
with related analyses. Notably, the methodology ensures that differences in physician skills
do not affect the comparison of treatment methods, and random assignment was designed to
minimize bias by randomizing both by facility and physician proficiency factor.
The planned statistical analysis is appropriate, and the sample size appears to be adequately
determined for the study.
The quality of writing in the research protocol is acceptable.
Overall, the research protocol demonstrates a strong foundation for further examination and
contribution to the field of gastroenterology. I would recommend this paper for publication, with
minor revisions and clarifications as needed.
assistant