Reviewer's report
Title:Complicated coeliac disease: two different patterns of natural history, two
different prognoses. A multicentre case control study
Version:2Date:25 April 2014
Reviewer: Christophe Cellier
Reviewer's report:
This study describes, in a multicentre retrospective study, the various forms of
complicated celiac disease, as well their prognosis and show that complicated
celiac disease may be a serious condition..
The major weakness of the study is that data regarding the diagnosis of these
complicated CCD in term of endoscopic, radiological, histological (and
phenotypic) features are missing. Furthermore neither the adherence to the
gluten free diet, nor the treatment used for these patients are described. Thus it
remains difficult to draw any clear conclusions from such study.
If available such data should be provided in the manuscript.
For example, ulcerative jejunitis may be frequently associated with RCD type 2 or
EATL, but its is not clearly assessed in this paper, regarding the initial diagnostic
work-up.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interest
Reviewer's report
Title:Complicated coeliac disease: two different patterns of natural history, two
different prognoses. A multicentre case control study
Version:2Date:25 April 2014
Reviewer: Christophe Cellier
Reviewer's report:
This study describes, in a multicentre retrospective study, the various forms of
complicated celiac disease, as well their prognosis and show that complicated
celiac disease may be a serious condition..
The major weakness of the study is that data regarding the diagnosis of these
complicated CCD in term of endoscopic, radiological, histological (and
phenotypic) features are missing. Furthermore neither the adherence to the
gluten free diet, nor the treatment used for these patients are described. Thus it
remains difficult to draw any clear conclusions from such study.
If available such data should be provided in the manuscript.
For example, ulcerative jejunitis may be frequently associated with RCD type 2 or
EATL, but its is not clearly assessed in this paper, regarding the initial diagnostic
work-up.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interest
Please review this paper.
user
Reviewer's report
Title:Complicated coeliac disease: two different patterns of natural history, two
different prognoses. A multicentre case control study
Version:2Date:25 April 2014
Reviewer: Christophe Cellier
Reviewer's report:
This study describes, in a multicentre retrospective study, the various forms of
complicated celiac disease, as well their prognosis and show that complicated
celiac disease may be a serious condition..
The major weakness of the study is that data regarding the diagnosis of these
complicated CCD in term of endoscopic, radiological, histological (and
phenotypic) features are missing. Furthermore neither the adherence to the
gluten free diet, nor the treatment used for these patients are described. Thus it
remains difficult to draw any clear conclusions from such study.
If available such data should be provided in the manuscript.
For example, ulcerative jejunitis may be frequently associated with RCD type 2 or
EATL, but its is not clearly assessed in this paper, regarding the initial diagnostic
work-up.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interest
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