Title: Efficacy of Probiotic, Prebiotic, and Synbiotics Supplements in individuals with Anemia:
A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Version: 1 Date: 11 Nov 2024
Reviewer:  Roghayeh Molani-Gol
Reviewer's report:
Major Comments:
The Effects of Probiotic and Prebiotic Supplementation in anemia patients are interesting and
the study is well-designed, however, there are some points.
-Isn't there any study to assess the effects of probiotics or prebiotics on ferritin levels in patients
with anemia?
It is suggested to conduct a meta-analysis to combine these studies' results.
-Please correct the keywords. There is a duplicate keyword.
-Please add the number of studies obtained from the PubMed database to the table.
-The discussion section is brief. Please add more explanation about the possible mechanism of
the findings.
--There aren’t the funnel plots. Also, evaluate the publication bias by the funnel plot distribution.
Please add the funnel plots as supplementary figures. If there was an asymmetry in the funnel
plot, you could conduct a trim and fill test.
With best regards
Title: Efficacy of Probiotic, Prebiotic, and Synbiotics Supplements in individuals with Anemia:
A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Version: 1 Date: 11 Nov 2024
Reviewer:  Roghayeh Molani-Gol
Reviewer's report:
Major Comments:
The Effects of Probiotic and Prebiotic Supplementation in anemia patients are interesting and
the study is well-designed, however, there are some points.
-Isn't there any study to assess the effects of probiotics or prebiotics on ferritin levels in patients
with anemia?
It is suggested to conduct a meta-analysis to combine these studies' results.
-Please correct the keywords. There is a duplicate keyword.
-Please add the number of studies obtained from the PubMed database to the table.
-The discussion section is brief. Please add more explanation about the possible mechanism of
the findings.
--There aren’t the funnel plots. Also, evaluate the publication bias by the funnel plot distribution.
Please add the funnel plots as supplementary figures. If there was an asymmetry in the funnel
plot, you could conduct a trim and fill test.
With best regards
Please review this paper.
user
Title: Efficacy of Probiotic, Prebiotic, and Synbiotics Supplements in individuals with Anemia:
A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Version: 1 Date: 11 Nov 2024
Reviewer:  Roghayeh Molani-Gol
Reviewer's report:
Major Comments:
The Effects of Probiotic and Prebiotic Supplementation in anemia patients are interesting and
the study is well-designed, however, there are some points.
-Isn't there any study to assess the effects of probiotics or prebiotics on ferritin levels in patients
with anemia?
It is suggested to conduct a meta-analysis to combine these studies' results.
-Please correct the keywords. There is a duplicate keyword.
-Please add the number of studies obtained from the PubMed database to the table.
-The discussion section is brief. Please add more explanation about the possible mechanism of
the findings.
--There aren’t the funnel plots. Also, evaluate the publication bias by the funnel plot distribution.
Please add the funnel plots as supplementary figures. If there was an asymmetry in the funnel
plot, you could conduct a trim and fill test.
With best regards
assistant