Title: Development and validation of a nomogram for prediction of cervical lymph node
metastasis in middle and lower thoracic esophageal squamous cell carcinoma
Version: 1 Date: 03 Mar 2022
Reviewer's report:
Thank you for the opportunity to review this manuscript. The authors developed the nomogram
using four variables for prediction of cervical lymph node metastasis in patients with middle or
lower thoracic esophageal squamous cell carcinoma.
This manuscript is well-written and valuable. There are some points to be addressed before
publication.
1. The location of the mediastinal lymph node, paraesophageal lymph node, and cervical lymph
node are unclear. The authors should define the location of these lymph nodes clearly using
the image. Moreover, does the cervical lymph include supraclavicular lymph node other than
cervical paraesophageal lymph node?
2. The authors should describe the treatment strategy of esophageal squamous cell carcinoma.
3. Why did the authors exclude the patients who underwent preoperative chemotherapy or
radiation therapy?
4. There was no definition of CT-reported cervical lymph node status positive.
5. Does three-field lymphadenectomy include supraclavicular lymph node dissection?
Title: Development and validation of a nomogram for prediction of cervical lymph node
metastasis in middle and lower thoracic esophageal squamous cell carcinoma
Version: 1 Date: 03 Mar 2022
Reviewer's report:
Thank you for the opportunity to review this manuscript. The authors developed the nomogram
using four variables for prediction of cervical lymph node metastasis in patients with middle or
lower thoracic esophageal squamous cell carcinoma.
This manuscript is well-written and valuable. There are some points to be addressed before
publication.
1. The location of the mediastinal lymph node, paraesophageal lymph node, and cervical lymph
node are unclear. The authors should define the location of these lymph nodes clearly using
the image. Moreover, does the cervical lymph include supraclavicular lymph node other than
cervical paraesophageal lymph node?
2. The authors should describe the treatment strategy of esophageal squamous cell carcinoma.
3. Why did the authors exclude the patients who underwent preoperative chemotherapy or
radiation therapy?
4. There was no definition of CT-reported cervical lymph node status positive.
5. Does three-field lymphadenectomy include supraclavicular lymph node dissection?
Please review this paper.
user
Title: Development and validation of a nomogram for prediction of cervical lymph node
metastasis in middle and lower thoracic esophageal squamous cell carcinoma
Version: 1 Date: 03 Mar 2022
Reviewer's report:
Thank you for the opportunity to review this manuscript. The authors developed the nomogram
using four variables for prediction of cervical lymph node metastasis in patients with middle or
lower thoracic esophageal squamous cell carcinoma.
This manuscript is well-written and valuable. There are some points to be addressed before
publication.
1. The location of the mediastinal lymph node, paraesophageal lymph node, and cervical lymph
node are unclear. The authors should define the location of these lymph nodes clearly using
the image. Moreover, does the cervical lymph include supraclavicular lymph node other than
cervical paraesophageal lymph node?
2. The authors should describe the treatment strategy of esophageal squamous cell carcinoma.
3. Why did the authors exclude the patients who underwent preoperative chemotherapy or
radiation therapy?
4. There was no definition of CT-reported cervical lymph node status positive.
5. Does three-field lymphadenectomy include supraclavicular lymph node dissection?
assistant