Reviewer's report
Title:Effects of omeprazole on symptoms and quality of life in Japanese patients
with reflux esophagitis: Final results of OMAREE, a large-scale clinical
experience investigation
Version: 2Date:24 December 2010
Reviewer: Mattijs E Numans
Reviewer's report:
This still is an interesting study in a large population and I agree with the authors
that its relevance is that it is closer to real practice than many RCTs can ever be.
My point of potential "bias by indication" (selection towards more serious
symptomatology, knowing that PPIs have a more longstanding and profound
effect than other antisecretory drugs especially in patients with erosive lesions)
has been taken by the authors in their cover letter, but not in the manuscript text.
However, I can live with it beint left as is. It might be overcome indeed by the
large number of participants and partly by the 4:1 strategy PPI:other drugs at
inclusion. So I would agree with publication of the revised version.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interests
Reviewer's report
Title:Effects of omeprazole on symptoms and quality of life in Japanese patients
with reflux esophagitis: Final results of OMAREE, a large-scale clinical
experience investigation
Version: 2Date:24 December 2010
Reviewer: Mattijs E Numans
Reviewer's report:
This still is an interesting study in a large population and I agree with the authors
that its relevance is that it is closer to real practice than many RCTs can ever be.
My point of potential "bias by indication" (selection towards more serious
symptomatology, knowing that PPIs have a more longstanding and profound
effect than other antisecretory drugs especially in patients with erosive lesions)
has been taken by the authors in their cover letter, but not in the manuscript text.
However, I can live with it beint left as is. It might be overcome indeed by the
large number of participants and partly by the 4:1 strategy PPI:other drugs at
inclusion. So I would agree with publication of the revised version.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Effects of omeprazole on symptoms and quality of life in Japanese patients
with reflux esophagitis: Final results of OMAREE, a large-scale clinical
experience investigation
Version: 2Date:24 December 2010
Reviewer: Mattijs E Numans
Reviewer's report:
This still is an interesting study in a large population and I agree with the authors
that its relevance is that it is closer to real practice than many RCTs can ever be.
My point of potential "bias by indication" (selection towards more serious
symptomatology, knowing that PPIs have a more longstanding and profound
effect than other antisecretory drugs especially in patients with erosive lesions)
has been taken by the authors in their cover letter, but not in the manuscript text.
However, I can live with it beint left as is. It might be overcome indeed by the
large number of participants and partly by the 4:1 strategy PPI:other drugs at
inclusion. So I would agree with publication of the revised version.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interests
assistant