Title: Genetically Predicted Gut Microbiota Mediate the Association Between Plasma
Lipidomics and Primary Sclerosing Cholangitis
Version: 0 Date: 14 Apr 2024
Reviewer's report:
The paper used plasma lipidome data from a study involving Finnish population and microbiota
data from a study based on Dutch population and used various statistical tools to try to establish
a relationship between plasma metabolites and gut bacteria in PSC.
The major concern I have is the data heterogeneity (lipid data from a study involving Finnish
population, SNPs from multiple studies and microbiota data from study from Dutch population).
PSC is suggested to have considerable heterogeneity in the geoepidemiology (see publications
listed below). Different diets shape gut microbiome, which would invalidate the approach to
try to establish a relationship between plasma lipids from one population and gut bacteria from
another. The lipid source data investigators used were from short gun lipidomics approach,
which are questionable to annotate lipid to the subspecies level, such as PC(o-16:1_18:1).
Therefore, the association of a nonconfirmed lipid, PC(o-16:1_18:1) levels in PSC and suggested
effect by Eubacterium rectale are not convincing. I regret to inform you of my decision to reject
this work to be published in BMC Gastroenterology.
Tej I. Mehta, et al. Global incidence, prevalence and features of primary sclerosing cholangitis:
A systematic review and meta-analysis. Liver International, 2021.
Palak J. Trivedi, et al. Epidemiology, Natural History, and Outcomes of Primary Sclerosing
Cholangitis: A Systematic Review of Population-based Studies. Clinical Gastroenterology and
Hepatology 2022.
Title: Genetically Predicted Gut Microbiota Mediate the Association Between Plasma
Lipidomics and Primary Sclerosing Cholangitis
Version: 0 Date: 14 Apr 2024
Reviewer's report:
The paper used plasma lipidome data from a study involving Finnish population and microbiota
data from a study based on Dutch population and used various statistical tools to try to establish
a relationship between plasma metabolites and gut bacteria in PSC.
The major concern I have is the data heterogeneity (lipid data from a study involving Finnish
population, SNPs from multiple studies and microbiota data from study from Dutch population).
PSC is suggested to have considerable heterogeneity in the geoepidemiology (see publications
listed below). Different diets shape gut microbiome, which would invalidate the approach to
try to establish a relationship between plasma lipids from one population and gut bacteria from
another. The lipid source data investigators used were from short gun lipidomics approach,
which are questionable to annotate lipid to the subspecies level, such as PC(o-16:1_18:1).
Therefore, the association of a nonconfirmed lipid, PC(o-16:1_18:1) levels in PSC and suggested
effect by Eubacterium rectale are not convincing. I regret to inform you of my decision to reject
this work to be published in BMC Gastroenterology.
Tej I. Mehta, et al. Global incidence, prevalence and features of primary sclerosing cholangitis:
A systematic review and meta-analysis. Liver International, 2021.
Palak J. Trivedi, et al. Epidemiology, Natural History, and Outcomes of Primary Sclerosing
Cholangitis: A Systematic Review of Population-based Studies. Clinical Gastroenterology and
Hepatology 2022.
Please review this paper.
user
Title: Genetically Predicted Gut Microbiota Mediate the Association Between Plasma
Lipidomics and Primary Sclerosing Cholangitis
Version: 0 Date: 14 Apr 2024
Reviewer's report:
The paper used plasma lipidome data from a study involving Finnish population and microbiota
data from a study based on Dutch population and used various statistical tools to try to establish
a relationship between plasma metabolites and gut bacteria in PSC.
The major concern I have is the data heterogeneity (lipid data from a study involving Finnish
population, SNPs from multiple studies and microbiota data from study from Dutch population).
PSC is suggested to have considerable heterogeneity in the geoepidemiology (see publications
listed below). Different diets shape gut microbiome, which would invalidate the approach to
try to establish a relationship between plasma lipids from one population and gut bacteria from
another. The lipid source data investigators used were from short gun lipidomics approach,
which are questionable to annotate lipid to the subspecies level, such as PC(o-16:1_18:1).
Therefore, the association of a nonconfirmed lipid, PC(o-16:1_18:1) levels in PSC and suggested
effect by Eubacterium rectale are not convincing. I regret to inform you of my decision to reject
this work to be published in BMC Gastroenterology.
Tej I. Mehta, et al. Global incidence, prevalence and features of primary sclerosing cholangitis:
A systematic review and meta-analysis. Liver International, 2021.
Palak J. Trivedi, et al. Epidemiology, Natural History, and Outcomes of Primary Sclerosing
Cholangitis: A Systematic Review of Population-based Studies. Clinical Gastroenterology and
Hepatology 2022.
assistant