Title: Comparison of conventional MRI analysis versus MRI-based radiomics to predict the
circumferential margin resection involvement of rectal cancer
Version: 1 Date: 21 Jan 2024
Reviewer:  Pablo Palma
Reviewer's report:
The abstract is well-structured and provides understanding of the research objective, methods,
and results.
The cohort of patients included raises a number of important questions: How can there be
such a high number of patients with circumferential margin involvement where no neoadjuvant
treatment has been applied?
The statistical metrics (AUC) are appropriately used to quantify the predictive performance of
each model.
Consider providing more context on the clinical implications and potential applications of the
study findings.
In this context, the implications of an affected circumferential margin, both before and after
surgery, are not well defined and explained, especially in the introduction and discussion of the
manuscript, and should be thoroughly reviewed.
It would be very interesting if the authors could comment on the value of this research in patients
after neoadjuvant treatment, as a re-staging of their rectal cancer.
Title: Comparison of conventional MRI analysis versus MRI-based radiomics to predict the
circumferential margin resection involvement of rectal cancer
Version: 1 Date: 21 Jan 2024
Reviewer:  Pablo Palma
Reviewer's report:
The abstract is well-structured and provides understanding of the research objective, methods,
and results.
The cohort of patients included raises a number of important questions: How can there be
such a high number of patients with circumferential margin involvement where no neoadjuvant
treatment has been applied?
The statistical metrics (AUC) are appropriately used to quantify the predictive performance of
each model.
Consider providing more context on the clinical implications and potential applications of the
study findings.
In this context, the implications of an affected circumferential margin, both before and after
surgery, are not well defined and explained, especially in the introduction and discussion of the
manuscript, and should be thoroughly reviewed.
It would be very interesting if the authors could comment on the value of this research in patients
after neoadjuvant treatment, as a re-staging of their rectal cancer.
Please review this paper.
user
Title: Comparison of conventional MRI analysis versus MRI-based radiomics to predict the
circumferential margin resection involvement of rectal cancer
Version: 1 Date: 21 Jan 2024
Reviewer:  Pablo Palma
Reviewer's report:
The abstract is well-structured and provides understanding of the research objective, methods,
and results.
The cohort of patients included raises a number of important questions: How can there be
such a high number of patients with circumferential margin involvement where no neoadjuvant
treatment has been applied?
The statistical metrics (AUC) are appropriately used to quantify the predictive performance of
each model.
Consider providing more context on the clinical implications and potential applications of the
study findings.
In this context, the implications of an affected circumferential margin, both before and after
surgery, are not well defined and explained, especially in the introduction and discussion of the
manuscript, and should be thoroughly reviewed.
It would be very interesting if the authors could comment on the value of this research in patients
after neoadjuvant treatment, as a re-staging of their rectal cancer.
assistant