Title: Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients
Version: 3 Date: 04 Jan 2025
Reviewer:  Masahiro Hatori
Reviewer's report:
The main objective of this study was to reveal that determining whether the FIB-4 index, ALBI
score, APRI, and GPR were significant as the prognostic factors in colorectal cancer (CRC)
patients with liver metastasis who had not previously received any systemic chemotherapy or
local ablative therapy or who had undergone surgery.
In the clinical practice, physicians need the noninvasive parameter/biomarker when they had
to evaluate simply the prognosis in patients with CRC. The suggested prognostic factors were
simple, and no need to add blood test. I have regarded this manuscript important one because
there was no report which various factors were analyzed all at once in CRC patients.
I would like to make some comments on the study to develop one:
-Major points,
(1) How many cutoffs of parameter did you analyze? It is very important to consider
reproducibility to conduct other study.
(2) Please clarify how alive or dead of patients are divided into two groups and demonstrate the
follow up time to verify alive or dead.
(3) Please clarify whether the multicollinearity of parameters was or not when you conducted
multivariate analysis. If there was the multicollinearity, you could not conduct multivariate
analysis.
(4) Why did not you add the other prognostic independent variable but these parameters? When
you did not add the previous reported prognosis factors (e.g., performance status, LDH, and
BMI), the impact level of these parameters was possibly unclear.
(5) It is very important to examine content of chemotherapy or surgery when you analyzed
overall survival. Please demonstrate the content of chemotherapy and surgery performed from
recruitment and add them as the independent variable.
Title: Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients
Version: 3 Date: 04 Jan 2025
Reviewer:  Masahiro Hatori
Reviewer's report:
The main objective of this study was to reveal that determining whether the FIB-4 index, ALBI
score, APRI, and GPR were significant as the prognostic factors in colorectal cancer (CRC)
patients with liver metastasis who had not previously received any systemic chemotherapy or
local ablative therapy or who had undergone surgery.
In the clinical practice, physicians need the noninvasive parameter/biomarker when they had
to evaluate simply the prognosis in patients with CRC. The suggested prognostic factors were
simple, and no need to add blood test. I have regarded this manuscript important one because
there was no report which various factors were analyzed all at once in CRC patients.
I would like to make some comments on the study to develop one:
-Major points,
(1) How many cutoffs of parameter did you analyze? It is very important to consider
reproducibility to conduct other study.
(2) Please clarify how alive or dead of patients are divided into two groups and demonstrate the
follow up time to verify alive or dead.
(3) Please clarify whether the multicollinearity of parameters was or not when you conducted
multivariate analysis. If there was the multicollinearity, you could not conduct multivariate
analysis.
(4) Why did not you add the other prognostic independent variable but these parameters? When
you did not add the previous reported prognosis factors (e.g., performance status, LDH, and
BMI), the impact level of these parameters was possibly unclear.
(5) It is very important to examine content of chemotherapy or surgery when you analyzed
overall survival. Please demonstrate the content of chemotherapy and surgery performed from
recruitment and add them as the independent variable.
Please review this paper.
user
Title: Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients
Version: 3 Date: 04 Jan 2025
Reviewer:  Masahiro Hatori
Reviewer's report:
The main objective of this study was to reveal that determining whether the FIB-4 index, ALBI
score, APRI, and GPR were significant as the prognostic factors in colorectal cancer (CRC)
patients with liver metastasis who had not previously received any systemic chemotherapy or
local ablative therapy or who had undergone surgery.
In the clinical practice, physicians need the noninvasive parameter/biomarker when they had
to evaluate simply the prognosis in patients with CRC. The suggested prognostic factors were
simple, and no need to add blood test. I have regarded this manuscript important one because
there was no report which various factors were analyzed all at once in CRC patients.
I would like to make some comments on the study to develop one:
-Major points,
(1) How many cutoffs of parameter did you analyze? It is very important to consider
reproducibility to conduct other study.
(2) Please clarify how alive or dead of patients are divided into two groups and demonstrate the
follow up time to verify alive or dead.
(3) Please clarify whether the multicollinearity of parameters was or not when you conducted
multivariate analysis. If there was the multicollinearity, you could not conduct multivariate
analysis.
(4) Why did not you add the other prognostic independent variable but these parameters? When
you did not add the previous reported prognosis factors (e.g., performance status, LDH, and
BMI), the impact level of these parameters was possibly unclear.
(5) It is very important to examine content of chemotherapy or surgery when you analyzed
overall survival. Please demonstrate the content of chemotherapy and surgery performed from
recruitment and add them as the independent variable.
assistant