Reviewer ’s report  
 
Title: Surgical Treatment and Prognosis of Gastric Neuroendocrine Neoplasms: A Single -center 
Experience  
 
 
Version: 0 Date: 25 Apr 2016  
 
 
Reviewer: Maria  Russell  
 
 
Reviewer's report:  
 
Thank you for the opportunity to review the manuscript, "Surgical Treatment and Prognosis of 
Gastric Neuroendocrine Neoplasms: A Singlecenter  
Experience".  Please see below for comments and questions:  
 
1.  Please make sure to su bmit your manuscript for English review.  There are several phrases 
and wordings throughout the paper which are not quite right.  
(ex.  Line 187 - "statistically significant significances").  
2.  Is there literature to support at D2 resection for gastric ne uroendocrine tumors?  
3.  It is not usually considered standard of care to operate on G3 lesions consistent with small 
cell NET.  Can you please provide the rationale for operating on the highly aggressive cohort?  
4.  What is the role for palliative resecti on in NET?  
5.  Lines 234 -237 - spell out abbreviations.  
6.  After controlling for tumor factors, was endoscopic resection still significant for overall 
survival?  
7.  In your discussion, there is a lot of talk about other NEN - small bowel, rectum, pancreas.  
Please confirm that the study is specific for "Gastric"?  
8.  Delete "and so on" line 326 -327. 
9.  Have you considered looking at the effect of chemo only in th e more advanced stage disease 
patients?  
10.  Please include a limitations paragraph.  
11.  What will be the next step in the research?  
12.  Stages I and II cross on the KM curve at 5 years.  Please comment.  
 
Thank you for allowing me to review this manuscri pt. 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to th e authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistic al review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the  manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from 
an organisation that may in any way ga in or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the f uture?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my  report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access C reative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Surgical Treatment and Prognosis of Gastric Neuroendocrine Neoplasms: A Single -center 
Experience  
 
 
Version: 0 Date: 25 Apr 2016  
 
 
Reviewer: Maria  Russell  
 
 
Reviewer's report:  
 
Thank you for the opportunity to review the manuscript, "Surgical Treatment and Prognosis of 
Gastric Neuroendocrine Neoplasms: A Singlecenter  
Experience".  Please see below for comments and questions:  
 
1.  Please make sure to su bmit your manuscript for English review.  There are several phrases 
and wordings throughout the paper which are not quite right.  
(ex.  Line 187 - "statistically significant significances").  
2.  Is there literature to support at D2 resection for gastric ne uroendocrine tumors?  
3.  It is not usually considered standard of care to operate on G3 lesions consistent with small 
cell NET.  Can you please provide the rationale for operating on the highly aggressive cohort?  
4.  What is the role for palliative resecti on in NET?  
5.  Lines 234 -237 - spell out abbreviations.  
6.  After controlling for tumor factors, was endoscopic resection still significant for overall 
survival?  
7.  In your discussion, there is a lot of talk about other NEN - small bowel, rectum, pancreas.  
Please confirm that the study is specific for "Gastric"?  
8.  Delete "and so on" line 326 -327. 
9.  Have you considered looking at the effect of chemo only in th e more advanced stage disease 
patients?  
10.  Please include a limitations paragraph.  
11.  What will be the next step in the research?  
12.  Stages I and II cross on the KM curve at 5 years.  Please comment.  
 
Thank you for allowing me to review this manuscri pt. 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to th e authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistic al review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the  manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from 
an organisation that may in any way ga in or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the f uture?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my  report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access C reative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Surgical Treatment and Prognosis of Gastric Neuroendocrine Neoplasms: A Single -center 
Experience  
 
 
Version: 0 Date: 25 Apr 2016  
 
 
Reviewer: Maria  Russell  
 
 
Reviewer's report:  
 
Thank you for the opportunity to review the manuscript, "Surgical Treatment and Prognosis of 
Gastric Neuroendocrine Neoplasms: A Singlecenter  
Experience".  Please see below for comments and questions:  
 
1.  Please make sure to su bmit your manuscript for English review.  There are several phrases 
and wordings throughout the paper which are not quite right.  
(ex.  Line 187 - "statistically significant significances").  
2.  Is there literature to support at D2 resection for gastric ne uroendocrine tumors?  
3.  It is not usually considered standard of care to operate on G3 lesions consistent with small 
cell NET.  Can you please provide the rationale for operating on the highly aggressive cohort?  
4.  What is the role for palliative resecti on in NET?  
5.  Lines 234 -237 - spell out abbreviations.  
6.  After controlling for tumor factors, was endoscopic resection still significant for overall 
survival?  
7.  In your discussion, there is a lot of talk about other NEN - small bowel, rectum, pancreas.  
Please confirm that the study is specific for "Gastric"?  
8.  Delete "and so on" line 326 -327. 
9.  Have you considered looking at the effect of chemo only in th e more advanced stage disease 
patients?  
10.  Please include a limitations paragraph.  
11.  What will be the next step in the research?  
12.  Stages I and II cross on the KM curve at 5 years.  Please comment.  
 
Thank you for allowing me to review this manuscri pt. 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to th e authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistic al review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the  manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from 
an organisation that may in any way ga in or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the f uture?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my  report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access C reative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant