Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactose
intolerance is not related to symptomatology
Version: 1Date:22 August 2009
Reviewer: Michele Di Stefano
Reviewer's report:
This paper evaluates a putative effect on lactose intolerance symptoms of the
polymorphism in the oxitocin promoter region. The Authors conclude that the
polymorphism does not play a pathophysiological role in this condition. The
paper is an interesting one, as the link between oxitocin and GI motility was
reported. Accordingly, the results of this paper may add something to our
understanding of the pathophysiology of functional GI symptoms.
Major compulsory revisions
1. The Authors should explain why they chose to study patients with lactose
malabsorption.
2. Moreover, they should indicate the final diagnosis of lactose tolerant patients
and, in the portion of this group suffering from functional GI disorders, they
should indicate whether the prevalence of the SNPs showed any differences.
3. Given the relationship between estrogen and oxitocin, female results should
be presented according to age and differences between males and females
should also be searched for.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactose
intolerance is not related to symptomatology
Version: 1Date:22 August 2009
Reviewer: Michele Di Stefano
Reviewer's report:
This paper evaluates a putative effect on lactose intolerance symptoms of the
polymorphism in the oxitocin promoter region. The Authors conclude that the
polymorphism does not play a pathophysiological role in this condition. The
paper is an interesting one, as the link between oxitocin and GI motility was
reported. Accordingly, the results of this paper may add something to our
understanding of the pathophysiology of functional GI symptoms.
Major compulsory revisions
1. The Authors should explain why they chose to study patients with lactose
malabsorption.
2. Moreover, they should indicate the final diagnosis of lactose tolerant patients
and, in the portion of this group suffering from functional GI disorders, they
should indicate whether the prevalence of the SNPs showed any differences.
3. Given the relationship between estrogen and oxitocin, female results should
be presented according to age and differences between males and females
should also be searched for.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Polymorphism in the oxytocin promoter region in patients with lactose
intolerance is not related to symptomatology
Version: 1Date:22 August 2009
Reviewer: Michele Di Stefano
Reviewer's report:
This paper evaluates a putative effect on lactose intolerance symptoms of the
polymorphism in the oxitocin promoter region. The Authors conclude that the
polymorphism does not play a pathophysiological role in this condition. The
paper is an interesting one, as the link between oxitocin and GI motility was
reported. Accordingly, the results of this paper may add something to our
understanding of the pathophysiology of functional GI symptoms.
Major compulsory revisions
1. The Authors should explain why they chose to study patients with lactose
malabsorption.
2. Moreover, they should indicate the final diagnosis of lactose tolerant patients
and, in the portion of this group suffering from functional GI disorders, they
should indicate whether the prevalence of the SNPs showed any differences.
3. Given the relationship between estrogen and oxitocin, female results should
be presented according to age and differences between males and females
should also be searched for.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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