Title: Liver histology pattern of young patients with inactive chronic hepatitis B virus infection
from a Hospital in South West Nigeria
Version: 4 Date: 23 Aug 2024
Reviewer's report:
This study offers valuable insights into the histological assessment of liver disease in young
patients with inactive chronic hepatitis B (CHB) in sub-Saharan Africa, particularly in Nigeria.
The research addresses a critical gap in understanding liver disease progression in this
demographic that existing guidelines have often overlooked.
The study is well-designed, but relying on a single ALT measurement may not fully capture
the dynamic nature of liver inflammation in CHB patients. Serial measurements could provide
a more comprehensive assessment.
The findings from this study suggest that significant liver disease can occur in young patients
with CHB, even when ALT levels and HBV DNA are low. This has important implications
for clinical practice, particularly in regions with high HBV prevalence. The study highlights
the need to reconsider current guidelines and suggests that liver biopsy may be warranted in a
broader range of patients than recommended.
Title: Liver histology pattern of young patients with inactive chronic hepatitis B virus infection
from a Hospital in South West Nigeria
Version: 4 Date: 23 Aug 2024
Reviewer's report:
This study offers valuable insights into the histological assessment of liver disease in young
patients with inactive chronic hepatitis B (CHB) in sub-Saharan Africa, particularly in Nigeria.
The research addresses a critical gap in understanding liver disease progression in this
demographic that existing guidelines have often overlooked.
The study is well-designed, but relying on a single ALT measurement may not fully capture
the dynamic nature of liver inflammation in CHB patients. Serial measurements could provide
a more comprehensive assessment.
The findings from this study suggest that significant liver disease can occur in young patients
with CHB, even when ALT levels and HBV DNA are low. This has important implications
for clinical practice, particularly in regions with high HBV prevalence. The study highlights
the need to reconsider current guidelines and suggests that liver biopsy may be warranted in a
broader range of patients than recommended.
Please review this paper.
user
Title: Liver histology pattern of young patients with inactive chronic hepatitis B virus infection
from a Hospital in South West Nigeria
Version: 4 Date: 23 Aug 2024
Reviewer's report:
This study offers valuable insights into the histological assessment of liver disease in young
patients with inactive chronic hepatitis B (CHB) in sub-Saharan Africa, particularly in Nigeria.
The research addresses a critical gap in understanding liver disease progression in this
demographic that existing guidelines have often overlooked.
The study is well-designed, but relying on a single ALT measurement may not fully capture
the dynamic nature of liver inflammation in CHB patients. Serial measurements could provide
a more comprehensive assessment.
The findings from this study suggest that significant liver disease can occur in young patients
with CHB, even when ALT levels and HBV DNA are low. This has important implications
for clinical practice, particularly in regions with high HBV prevalence. The study highlights
the need to reconsider current guidelines and suggests that liver biopsy may be warranted in a
broader range of patients than recommended.
assistant