Reviewer's report
Title:Increased use of hypnotics in individuals with celiac disease: A nationwide
case-control study
Version:1Date:12 November 2014
Reviewer: Edward Bixler
Reviewer's report:
This study was based on a nationwide case-control sample from the Swedish
general population. The cases were defined as those with celiac disease based
on a biopsy showing villous atrophy compared to a matched sample of controls.
Insomnia was defined in both samples based on #2 prescriptions of hypnotics.
The authors conclude that patients with celiac disease have an increased risk for
insomnia and that insomnia may be a manifestation of celiac disease.
This study is addressing an interesting question. The sample and analysis
appear to be well defined and appropriate. They do not have a direct assessment
of insomnia, relying on hypnotic prescription as a surrogate. Thus labeling this
outcome as insomnia may be overstating the data. Perhaps a label of poor sleep
or sleep complaint might be more consistent with the data.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Increased use of hypnotics in individuals with celiac disease: A nationwide
case-control study
Version:1Date:12 November 2014
Reviewer: Edward Bixler
Reviewer's report:
This study was based on a nationwide case-control sample from the Swedish
general population. The cases were defined as those with celiac disease based
on a biopsy showing villous atrophy compared to a matched sample of controls.
Insomnia was defined in both samples based on #2 prescriptions of hypnotics.
The authors conclude that patients with celiac disease have an increased risk for
insomnia and that insomnia may be a manifestation of celiac disease.
This study is addressing an interesting question. The sample and analysis
appear to be well defined and appropriate. They do not have a direct assessment
of insomnia, relying on hypnotic prescription as a surrogate. Thus labeling this
outcome as insomnia may be overstating the data. Perhaps a label of poor sleep
or sleep complaint might be more consistent with the data.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Increased use of hypnotics in individuals with celiac disease: A nationwide
case-control study
Version:1Date:12 November 2014
Reviewer: Edward Bixler
Reviewer's report:
This study was based on a nationwide case-control sample from the Swedish
general population. The cases were defined as those with celiac disease based
on a biopsy showing villous atrophy compared to a matched sample of controls.
Insomnia was defined in both samples based on #2 prescriptions of hypnotics.
The authors conclude that patients with celiac disease have an increased risk for
insomnia and that insomnia may be a manifestation of celiac disease.
This study is addressing an interesting question. The sample and analysis
appear to be well defined and appropriate. They do not have a direct assessment
of insomnia, relying on hypnotic prescription as a surrogate. Thus labeling this
outcome as insomnia may be overstating the data. Perhaps a label of poor sleep
or sleep complaint might be more consistent with the data.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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