Title: Associations between changes in the gut microbiota and liver cirrhosis: a systematic
review and meta-analysis
Version: 0 Date: 16 Oct 2024
Reviewer:  Maged Tharwat Elghannam
Reviewer's report:
This manuscript, a meta-analysis study, discusses the changes in gut microbiota in patients
with liver cirrhosis of different etiologies. This information may be important in diagnosis and
therapy. It is not clear if these changes are the result or cause of the disease. A causal relationship
is needed.
Few comments:
-Non-alcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD)------------
> Metabolic-associated steatohepatitis (MASH) and metabolic-associated Fatty liver disease
(MASLD).
-Can you add a paragraph discussing how these results help prevent cirrhosis complications such
as HCC or hepatic encephalopathy?
-Is there any role for these gut microbiota changes in precipitating esophageal variceal bleeding?
Title: Associations between changes in the gut microbiota and liver cirrhosis: a systematic
review and meta-analysis
Version: 0 Date: 16 Oct 2024
Reviewer:  Maged Tharwat Elghannam
Reviewer's report:
This manuscript, a meta-analysis study, discusses the changes in gut microbiota in patients
with liver cirrhosis of different etiologies. This information may be important in diagnosis and
therapy. It is not clear if these changes are the result or cause of the disease. A causal relationship
is needed.
Few comments:
-Non-alcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD)------------
> Metabolic-associated steatohepatitis (MASH) and metabolic-associated Fatty liver disease
(MASLD).
-Can you add a paragraph discussing how these results help prevent cirrhosis complications such
as HCC or hepatic encephalopathy?
-Is there any role for these gut microbiota changes in precipitating esophageal variceal bleeding?
Please review this paper.
user
Title: Associations between changes in the gut microbiota and liver cirrhosis: a systematic
review and meta-analysis
Version: 0 Date: 16 Oct 2024
Reviewer:  Maged Tharwat Elghannam
Reviewer's report:
This manuscript, a meta-analysis study, discusses the changes in gut microbiota in patients
with liver cirrhosis of different etiologies. This information may be important in diagnosis and
therapy. It is not clear if these changes are the result or cause of the disease. A causal relationship
is needed.
Few comments:
-Non-alcoholic steatohepatitis (NASH), nonalcoholic fatty liver disease (NAFLD)------------
> Metabolic-associated steatohepatitis (MASH) and metabolic-associated Fatty liver disease
(MASLD).
-Can you add a paragraph discussing how these results help prevent cirrhosis complications such
as HCC or hepatic encephalopathy?
-Is there any role for these gut microbiota changes in precipitating esophageal variceal bleeding?
assistant