Title: ZBTB10 as a potential prognosis biomarker and correlates with tumor immune
microenvironment in stomach adenocarcinoma
Version: 2 Date: 06 Mar 2025
Reviewer's report:
Most of the concerns were addressed.
Overall, this study provides valuable insights into the role of ZBTB10 in STAD, and addressing
a few minor errors will further enhance the clarity and readability of the manuscript:
1. The study suggests that ZBTB10 is involved in tumor progression through the PI3K-Akt and
MAPK signaling pathways. However, no mechanistic validation (e.g., Western blot or functional
rescue experiments) is provided. The authors should either include additional experimental
evidence to confirm whether ZBTB10 directly regulates these pathways or acknowledge this
limitation in the discussion.
2. The authors should also discuss the importance of overexpressed ZBTB10 in gastric cancer
(GC) tissues compared to normal tissues and why ZBTB10 is overexpressed in cancerous tissues
should also be discussed.
3. The manuscript requires language polishing, as multiple typographical and grammatical errors
are present. Some examples include:
Line 34: Duplicate use of "in" in a single sentence.
Line 40: "appeared to negatively associated with" # "appeared to be negatively associated with."
Line 64: "ZBTB proteins family" # "ZBTB protein family"
Line 72: "the functions of ZBTB10 in STAD remains poorly studied" # "the functions of
ZBTB10 in STAD remain poorly studied"
Line 135: "biologic process" # "biological process."
Line 275: "a potential a risk factor" # "a potential risk factor."
Line 355: "identified the following several correlative pathways" # "identified several correlated
pathways"
Line 373: "was subjected to validated by" # "was validated by"
some simple tools such as "Grammarly" or other AI apps can help to improve the writing errors.
Title: ZBTB10 as a potential prognosis biomarker and correlates with tumor immune
microenvironment in stomach adenocarcinoma
Version: 2 Date: 06 Mar 2025
Reviewer's report:
Most of the concerns were addressed.
Overall, this study provides valuable insights into the role of ZBTB10 in STAD, and addressing
a few minor errors will further enhance the clarity and readability of the manuscript:
1. The study suggests that ZBTB10 is involved in tumor progression through the PI3K-Akt and
MAPK signaling pathways. However, no mechanistic validation (e.g., Western blot or functional
rescue experiments) is provided. The authors should either include additional experimental
evidence to confirm whether ZBTB10 directly regulates these pathways or acknowledge this
limitation in the discussion.
2. The authors should also discuss the importance of overexpressed ZBTB10 in gastric cancer
(GC) tissues compared to normal tissues and why ZBTB10 is overexpressed in cancerous tissues
should also be discussed.
3. The manuscript requires language polishing, as multiple typographical and grammatical errors
are present. Some examples include:
Line 34: Duplicate use of "in" in a single sentence.
Line 40: "appeared to negatively associated with" # "appeared to be negatively associated with."
Line 64: "ZBTB proteins family" # "ZBTB protein family"
Line 72: "the functions of ZBTB10 in STAD remains poorly studied" # "the functions of
ZBTB10 in STAD remain poorly studied"
Line 135: "biologic process" # "biological process."
Line 275: "a potential a risk factor" # "a potential risk factor."
Line 355: "identified the following several correlative pathways" # "identified several correlated
pathways"
Line 373: "was subjected to validated by" # "was validated by"
some simple tools such as "Grammarly" or other AI apps can help to improve the writing errors.
Please review this paper.
user
Title: ZBTB10 as a potential prognosis biomarker and correlates with tumor immune
microenvironment in stomach adenocarcinoma
Version: 2 Date: 06 Mar 2025
Reviewer's report:
Most of the concerns were addressed.
Overall, this study provides valuable insights into the role of ZBTB10 in STAD, and addressing
a few minor errors will further enhance the clarity and readability of the manuscript:
1. The study suggests that ZBTB10 is involved in tumor progression through the PI3K-Akt and
MAPK signaling pathways. However, no mechanistic validation (e.g., Western blot or functional
rescue experiments) is provided. The authors should either include additional experimental
evidence to confirm whether ZBTB10 directly regulates these pathways or acknowledge this
limitation in the discussion.
2. The authors should also discuss the importance of overexpressed ZBTB10 in gastric cancer
(GC) tissues compared to normal tissues and why ZBTB10 is overexpressed in cancerous tissues
should also be discussed.
3. The manuscript requires language polishing, as multiple typographical and grammatical errors
are present. Some examples include:
Line 34: Duplicate use of "in" in a single sentence.
Line 40: "appeared to negatively associated with" # "appeared to be negatively associated with."
Line 64: "ZBTB proteins family" # "ZBTB protein family"
Line 72: "the functions of ZBTB10 in STAD remains poorly studied" # "the functions of
ZBTB10 in STAD remain poorly studied"
Line 135: "biologic process" # "biological process."
Line 275: "a potential a risk factor" # "a potential risk factor."
Line 355: "identified the following several correlative pathways" # "identified several correlated
pathways"
Line 373: "was subjected to validated by" # "was validated by"
some simple tools such as "Grammarly" or other AI apps can help to improve the writing errors.
assistant