Reviewer's report
Title:Prognostic impact of Immunohistochemical expression of CK7 and CK20 in
curatively resected ampulla of Vater cancer
Version:4Date:8 October 2015
Reviewer: Jae-Hoon Lee
Reviewer's report:
• Major Compulsory Revisions
• Minor Essential Revisions
1. In univariate analysis (Table-2), p-values are different from those were in
original manuscript while the number of cases, OS and DFS rates are identical.
Change was so substantial that statistical significance of variables have changed
quite much. In addition, I recommended minimizing the number of variables
included in the multivariate analysis and I believe that authors performed
multivariate analysis accordingly. However, all the values – number, hazard ratio,
and p-value - are definitely same as original analysis. It looks like that the row of
variable ‘subtype’ has been simply removed from the table in this revision. I am
not a statistical expert, but those statistical results should be verified again.
2. Result of CDX2 has been added in this revision. Relevant information needs to
be added in materials and methods section.
3. Background, line 14
“…CK7 positivity was considered as a common feature of intestinal type…” .
Pancreatobiliary type instead of intestinal?
4. Authors could consider including result of bilirubin level again in the
manuscript regardless of their statistical significance in the present study.
Bilirubin level is one of the important clinical factors in diseases of
pancreato-biliary tract.
• Discretionary Revisions
5. Minor comments:
- ‘Poorly differentiation’, ‘mod’ could be changed to ‘poor differentiation’
‘moderate (differentiation)’, or authors may use four-tier grading scale (G1-G4)
- Methods section, under heading of statistical analysis
Use full name instead of OS. Authors did not use abbreviations for survival
outcomes in the rest of manuscript.
- Tables: ‘AJCC’ stage instead of ‘overall’ stage as previously described in the
methods section.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Prognostic impact of Immunohistochemical expression of CK7 and CK20 in
curatively resected ampulla of Vater cancer
Version:4Date:8 October 2015
Reviewer: Jae-Hoon Lee
Reviewer's report:
• Major Compulsory Revisions
• Minor Essential Revisions
1. In univariate analysis (Table-2), p-values are different from those were in
original manuscript while the number of cases, OS and DFS rates are identical.
Change was so substantial that statistical significance of variables have changed
quite much. In addition, I recommended minimizing the number of variables
included in the multivariate analysis and I believe that authors performed
multivariate analysis accordingly. However, all the values – number, hazard ratio,
and p-value - are definitely same as original analysis. It looks like that the row of
variable ‘subtype’ has been simply removed from the table in this revision. I am
not a statistical expert, but those statistical results should be verified again.
2. Result of CDX2 has been added in this revision. Relevant information needs to
be added in materials and methods section.
3. Background, line 14
“…CK7 positivity was considered as a common feature of intestinal type…” .
Pancreatobiliary type instead of intestinal?
4. Authors could consider including result of bilirubin level again in the
manuscript regardless of their statistical significance in the present study.
Bilirubin level is one of the important clinical factors in diseases of
pancreato-biliary tract.
• Discretionary Revisions
5. Minor comments:
- ‘Poorly differentiation’, ‘mod’ could be changed to ‘poor differentiation’
‘moderate (differentiation)’, or authors may use four-tier grading scale (G1-G4)
- Methods section, under heading of statistical analysis
Use full name instead of OS. Authors did not use abbreviations for survival
outcomes in the rest of manuscript.
- Tables: ‘AJCC’ stage instead of ‘overall’ stage as previously described in the
methods section.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Prognostic impact of Immunohistochemical expression of CK7 and CK20 in
curatively resected ampulla of Vater cancer
Version:4Date:8 October 2015
Reviewer: Jae-Hoon Lee
Reviewer's report:
• Major Compulsory Revisions
• Minor Essential Revisions
1. In univariate analysis (Table-2), p-values are different from those were in
original manuscript while the number of cases, OS and DFS rates are identical.
Change was so substantial that statistical significance of variables have changed
quite much. In addition, I recommended minimizing the number of variables
included in the multivariate analysis and I believe that authors performed
multivariate analysis accordingly. However, all the values – number, hazard ratio,
and p-value - are definitely same as original analysis. It looks like that the row of
variable ‘subtype’ has been simply removed from the table in this revision. I am
not a statistical expert, but those statistical results should be verified again.
2. Result of CDX2 has been added in this revision. Relevant information needs to
be added in materials and methods section.
3. Background, line 14
“…CK7 positivity was considered as a common feature of intestinal type…” .
Pancreatobiliary type instead of intestinal?
4. Authors could consider including result of bilirubin level again in the
manuscript regardless of their statistical significance in the present study.
Bilirubin level is one of the important clinical factors in diseases of
pancreato-biliary tract.
• Discretionary Revisions
5. Minor comments:
- ‘Poorly differentiation’, ‘mod’ could be changed to ‘poor differentiation’
‘moderate (differentiation)’, or authors may use four-tier grading scale (G1-G4)
- Methods section, under heading of statistical analysis
Use full name instead of OS. Authors did not use abbreviations for survival
outcomes in the rest of manuscript.
- Tables: ‘AJCC’ stage instead of ‘overall’ stage as previously described in the
methods section.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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