Title: Risk factors for portal hypertensive gastropathy
Version: 3 Date: 11 Jun 2022
Reviewer:  Hidehiro Kamezaki
Reviewer's report:
Authors evaluated the incidence of PHG and explore the relationship between PHG and gender,
laboratory parameters, liver function and varicose veins. They concluded that albumin, the
degree of EV and GV are independent risk factors for the occurrence of PHG, and that improving
hypoalbuminemia and relieving the degree of varices may reduce the occurrence of PHG
and reduce the severity of PHG. However, these conclusions are too much leap and hard to
agree with. Also, it seems that the automatic translation of Chinese into English was used in
the production of the dissertation, and that English proofreading was not performed. Careless
mistakes are scattered.
#1: Page 1, line 1: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
#2: Page 2, line 2: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
#3: Page 3, line 10: the correct one is ‘‘20% to 98% of patients with cirrhosis’’, not ‘‘20% to
98%’’.
#4: Page 3, line 11: the correct one is ‘‘bleeding in patients with cirrhosis’’, not ‘‘bleeding’’.
#5: Page 3, line 18: the correct one is ‘‘etiology of cirrhosis, gender’’, not ‘‘etiology, gender
of cirrhosis’’.
#6: Page 4, line 4: the correct one is ‘‘hepatic venous pressure gradient (HVPG)’’, not ‘‘HVPG’’.
#7: Page 4, line 5: the correct one is ‘‘significant’’, not ‘‘signifificant’’.
#8: Page 4, line 6: the correct one is ‘‘esophageal varices (EV)’’, not ‘‘esophageal varices’’.
#8: Page 4, line 8: the correct one is ‘‘EV’’, not ‘‘oesophageal varices’’.
#9: Page 4, line 12: the correct one is ‘‘difference’’, not ‘‘difffference’’.
#10: Page 4, line 18: the correct one is ‘‘analysis of patients’’, not ‘‘analysis patients’’.
#11: Page 4, line 19: the correct one is ‘‘who underwent esophagogastroduodenoscopy’’, not
‘‘hospitalized’’.
#12: Page 5, line 3: dose the use of antibacterial affect PHG? Wouldn’t the use of antithrombotic
drugs affect PHG more?
#13: Page 5, line 4: the correct one is ‘‘in the past month’’, not ‘‘in recent January’’.
#14: Page 5, line 6: I’m not sure how to choose the exclusion criteria. Also, although it is a
retrospective study, it is stated that ‘‘Patient unwilling to give consent’’
#15: Page 5, line 19: the correct one is ‘‘the European Association for the Study of the Liver’’,
not ‘‘European Society for Liver Studies’’.
#16: Page 5, line 22: the correct one is ‘‘the American Association for the Study of Liver
Diseases’’, not ‘‘the American Association for the study of liver diseases’’.
#17: Page 6, a statement regarding ethical review is required.
#18: Page 7, line 4: the correct one is ‘‘significant differences’’, not ‘‘signifificant
difffferences’’.
#19: Page 7, line 5: the correct one is ‘‘leukocyte’’, not ‘‘Leukocyte’’.
#20: Page 7, line 8: the correct one is ‘‘in the no PHG group’’, not ‘‘in the PHG group’’.
#21: Page 7, line 10: the correct one is ‘‘than that in the no PHG group’’, not ‘‘than that in the
PHG group’’.
#22: Page 8, line 3: the correct one is ‘‘Child-Pugh B’’, not ‘‘child-Pugh B’’.
#23: Page 10, Table 3: the correct one is ‘‘Child-Pugh’’, not ‘‘Child-pugh’’.
#24: Page 10, Table 4: the correct one is ‘‘Child-Pugh’’, not ‘‘Child-pugh’’.
#25: Page 13, line 20: the correct one is ‘‘Child-Pugh C’’, not ‘‘Child-pugh C’’.
#26: Page 13, line 20: the correct one is ‘‘Child-Pugh B’’, not ‘‘Child-pugh B’’.
#27: Page 13, line 21: the correct one is ‘‘Child-Pugh C’’, not ‘‘child-pugh C’’.
#28: Page 13, line 22: the correct one is ‘‘Child-Pugh’’, not ‘‘child-pugh’’.
#29: Page 14, line 2: the correct one is ‘‘Child-Pugh B’’, not ‘‘Child-pugh B’’.
#30: Page 14, line 3: the correct one is ‘‘Child-Pugh A’’, not ‘‘Child-pugh A’’.
#31: Page 14, line 9: the correct one is ‘‘Child-Pugh’’, not ‘‘child-Pugh’’.
#32: Page 14, line 16: what does ‘‘kinyptide’’ mean?
#33: Page 15, line 5: the correct one is ‘‘EV’’, not ‘‘esophageal varices’’.
#34: Page 15, line 9: the correct one is ‘‘EV and GV’’, not ‘‘esophageal varices and gastric
varices’’.
#35: Page 16, line 11: the correct one is ‘‘Child-Pugh’’, not ‘‘child-pugh’’.
#36: Page 16, line 21: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
Title: Risk factors for portal hypertensive gastropathy
Version: 3 Date: 11 Jun 2022
Reviewer:  Hidehiro Kamezaki
Reviewer's report:
Authors evaluated the incidence of PHG and explore the relationship between PHG and gender,
laboratory parameters, liver function and varicose veins. They concluded that albumin, the
degree of EV and GV are independent risk factors for the occurrence of PHG, and that improving
hypoalbuminemia and relieving the degree of varices may reduce the occurrence of PHG
and reduce the severity of PHG. However, these conclusions are too much leap and hard to
agree with. Also, it seems that the automatic translation of Chinese into English was used in
the production of the dissertation, and that English proofreading was not performed. Careless
mistakes are scattered.
#1: Page 1, line 1: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
#2: Page 2, line 2: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
#3: Page 3, line 10: the correct one is ‘‘20% to 98% of patients with cirrhosis’’, not ‘‘20% to
98%’’.
#4: Page 3, line 11: the correct one is ‘‘bleeding in patients with cirrhosis’’, not ‘‘bleeding’’.
#5: Page 3, line 18: the correct one is ‘‘etiology of cirrhosis, gender’’, not ‘‘etiology, gender
of cirrhosis’’.
#6: Page 4, line 4: the correct one is ‘‘hepatic venous pressure gradient (HVPG)’’, not ‘‘HVPG’’.
#7: Page 4, line 5: the correct one is ‘‘significant’’, not ‘‘signifificant’’.
#8: Page 4, line 6: the correct one is ‘‘esophageal varices (EV)’’, not ‘‘esophageal varices’’.
#8: Page 4, line 8: the correct one is ‘‘EV’’, not ‘‘oesophageal varices’’.
#9: Page 4, line 12: the correct one is ‘‘difference’’, not ‘‘difffference’’.
#10: Page 4, line 18: the correct one is ‘‘analysis of patients’’, not ‘‘analysis patients’’.
#11: Page 4, line 19: the correct one is ‘‘who underwent esophagogastroduodenoscopy’’, not
‘‘hospitalized’’.
#12: Page 5, line 3: dose the use of antibacterial affect PHG? Wouldn’t the use of antithrombotic
drugs affect PHG more?
#13: Page 5, line 4: the correct one is ‘‘in the past month’’, not ‘‘in recent January’’.
#14: Page 5, line 6: I’m not sure how to choose the exclusion criteria. Also, although it is a
retrospective study, it is stated that ‘‘Patient unwilling to give consent’’
#15: Page 5, line 19: the correct one is ‘‘the European Association for the Study of the Liver’’,
not ‘‘European Society for Liver Studies’’.
#16: Page 5, line 22: the correct one is ‘‘the American Association for the Study of Liver
Diseases’’, not ‘‘the American Association for the study of liver diseases’’.
#17: Page 6, a statement regarding ethical review is required.
#18: Page 7, line 4: the correct one is ‘‘significant differences’’, not ‘‘signifificant
difffferences’’.
#19: Page 7, line 5: the correct one is ‘‘leukocyte’’, not ‘‘Leukocyte’’.
#20: Page 7, line 8: the correct one is ‘‘in the no PHG group’’, not ‘‘in the PHG group’’.
#21: Page 7, line 10: the correct one is ‘‘than that in the no PHG group’’, not ‘‘than that in the
PHG group’’.
#22: Page 8, line 3: the correct one is ‘‘Child-Pugh B’’, not ‘‘child-Pugh B’’.
#23: Page 10, Table 3: the correct one is ‘‘Child-Pugh’’, not ‘‘Child-pugh’’.
#24: Page 10, Table 4: the correct one is ‘‘Child-Pugh’’, not ‘‘Child-pugh’’.
#25: Page 13, line 20: the correct one is ‘‘Child-Pugh C’’, not ‘‘Child-pugh C’’.
#26: Page 13, line 20: the correct one is ‘‘Child-Pugh B’’, not ‘‘Child-pugh B’’.
#27: Page 13, line 21: the correct one is ‘‘Child-Pugh C’’, not ‘‘child-pugh C’’.
#28: Page 13, line 22: the correct one is ‘‘Child-Pugh’’, not ‘‘child-pugh’’.
#29: Page 14, line 2: the correct one is ‘‘Child-Pugh B’’, not ‘‘Child-pugh B’’.
#30: Page 14, line 3: the correct one is ‘‘Child-Pugh A’’, not ‘‘Child-pugh A’’.
#31: Page 14, line 9: the correct one is ‘‘Child-Pugh’’, not ‘‘child-Pugh’’.
#32: Page 14, line 16: what does ‘‘kinyptide’’ mean?
#33: Page 15, line 5: the correct one is ‘‘EV’’, not ‘‘esophageal varices’’.
#34: Page 15, line 9: the correct one is ‘‘EV and GV’’, not ‘‘esophageal varices and gastric
varices’’.
#35: Page 16, line 11: the correct one is ‘‘Child-Pugh’’, not ‘‘child-pugh’’.
#36: Page 16, line 21: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
Please review this paper.
user
Title: Risk factors for portal hypertensive gastropathy
Version: 3 Date: 11 Jun 2022
Reviewer:  Hidehiro Kamezaki
Reviewer's report:
Authors evaluated the incidence of PHG and explore the relationship between PHG and gender,
laboratory parameters, liver function and varicose veins. They concluded that albumin, the
degree of EV and GV are independent risk factors for the occurrence of PHG, and that improving
hypoalbuminemia and relieving the degree of varices may reduce the occurrence of PHG
and reduce the severity of PHG. However, these conclusions are too much leap and hard to
agree with. Also, it seems that the automatic translation of Chinese into English was used in
the production of the dissertation, and that English proofreading was not performed. Careless
mistakes are scattered.
#1: Page 1, line 1: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
#2: Page 2, line 2: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
#3: Page 3, line 10: the correct one is ‘‘20% to 98% of patients with cirrhosis’’, not ‘‘20% to
98%’’.
#4: Page 3, line 11: the correct one is ‘‘bleeding in patients with cirrhosis’’, not ‘‘bleeding’’.
#5: Page 3, line 18: the correct one is ‘‘etiology of cirrhosis, gender’’, not ‘‘etiology, gender
of cirrhosis’’.
#6: Page 4, line 4: the correct one is ‘‘hepatic venous pressure gradient (HVPG)’’, not ‘‘HVPG’’.
#7: Page 4, line 5: the correct one is ‘‘significant’’, not ‘‘signifificant’’.
#8: Page 4, line 6: the correct one is ‘‘esophageal varices (EV)’’, not ‘‘esophageal varices’’.
#8: Page 4, line 8: the correct one is ‘‘EV’’, not ‘‘oesophageal varices’’.
#9: Page 4, line 12: the correct one is ‘‘difference’’, not ‘‘difffference’’.
#10: Page 4, line 18: the correct one is ‘‘analysis of patients’’, not ‘‘analysis patients’’.
#11: Page 4, line 19: the correct one is ‘‘who underwent esophagogastroduodenoscopy’’, not
‘‘hospitalized’’.
#12: Page 5, line 3: dose the use of antibacterial affect PHG? Wouldn’t the use of antithrombotic
drugs affect PHG more?
#13: Page 5, line 4: the correct one is ‘‘in the past month’’, not ‘‘in recent January’’.
#14: Page 5, line 6: I’m not sure how to choose the exclusion criteria. Also, although it is a
retrospective study, it is stated that ‘‘Patient unwilling to give consent’’
#15: Page 5, line 19: the correct one is ‘‘the European Association for the Study of the Liver’’,
not ‘‘European Society for Liver Studies’’.
#16: Page 5, line 22: the correct one is ‘‘the American Association for the Study of Liver
Diseases’’, not ‘‘the American Association for the study of liver diseases’’.
#17: Page 6, a statement regarding ethical review is required.
#18: Page 7, line 4: the correct one is ‘‘significant differences’’, not ‘‘signifificant
difffferences’’.
#19: Page 7, line 5: the correct one is ‘‘leukocyte’’, not ‘‘Leukocyte’’.
#20: Page 7, line 8: the correct one is ‘‘in the no PHG group’’, not ‘‘in the PHG group’’.
#21: Page 7, line 10: the correct one is ‘‘than that in the no PHG group’’, not ‘‘than that in the
PHG group’’.
#22: Page 8, line 3: the correct one is ‘‘Child-Pugh B’’, not ‘‘child-Pugh B’’.
#23: Page 10, Table 3: the correct one is ‘‘Child-Pugh’’, not ‘‘Child-pugh’’.
#24: Page 10, Table 4: the correct one is ‘‘Child-Pugh’’, not ‘‘Child-pugh’’.
#25: Page 13, line 20: the correct one is ‘‘Child-Pugh C’’, not ‘‘Child-pugh C’’.
#26: Page 13, line 20: the correct one is ‘‘Child-Pugh B’’, not ‘‘Child-pugh B’’.
#27: Page 13, line 21: the correct one is ‘‘Child-Pugh C’’, not ‘‘child-pugh C’’.
#28: Page 13, line 22: the correct one is ‘‘Child-Pugh’’, not ‘‘child-pugh’’.
#29: Page 14, line 2: the correct one is ‘‘Child-Pugh B’’, not ‘‘Child-pugh B’’.
#30: Page 14, line 3: the correct one is ‘‘Child-Pugh A’’, not ‘‘Child-pugh A’’.
#31: Page 14, line 9: the correct one is ‘‘Child-Pugh’’, not ‘‘child-Pugh’’.
#32: Page 14, line 16: what does ‘‘kinyptide’’ mean?
#33: Page 15, line 5: the correct one is ‘‘EV’’, not ‘‘esophageal varices’’.
#34: Page 15, line 9: the correct one is ‘‘EV and GV’’, not ‘‘esophageal varices and gastric
varices’’.
#35: Page 16, line 11: the correct one is ‘‘Child-Pugh’’, not ‘‘child-pugh’’.
#36: Page 16, line 21: the correct one is ‘‘hypertensive’’, not ‘‘hypertension’’.
assistant