Reviewer's report
 Melatonin reduces cytokine induced expression of MAdCAM-1: Implications for IBD therapy. Title:
Authors:
Makotoh Sasaki MD (msasak@lsuhsc.edu )
Paul Jordan MD (pjorda1@lsuhsc.edu )
Takashi Joh MD (jalexa@lsuhsc.edu )
Makotoh Itoh MD (jalexa@lsuhsc.edu )
Michael Jenkins (michael.jenkins@virgin.net )
Kevin Pavlick PhD (kpavli@lsuhsc.edu )
Alireza Minagar MD (kaminag@lsuhsc.edu )
J Steven Alexander PhD (jalexa@lsuhsc.edu )
 4  9 Apr 2002 Version: Date:
 Wayne Patton Reviewer:
 A paper whose findings are important to those with closely related research interests Level of interest:
 Reject Advice on publication:
The revised manuscript was for the most part unresponsive to the reviewer's 
previous critique. Compulsory revisions 3 and 5-10 were not addressed in the 
revised manuscript. Criticism 4 was only partially addressed, it is important 
to explicitly state that the cell line is "an SV-40 transformed mouse lymphoid 
endothelial cell line". None of the other compulsory corrections were made at 
all. Without incorporation of the changes outlined in the previous review, I 
strongly recommend rejection of the manuscript. 
Competing interests:
The reviewer has no financial competing interests with regard to the paper. From 1987-1989, the 
reviewer did serve in the same academic laboratory as the senior author of the paper. This laboratory 
investigated cytoskeletal regulation of endothelial cell inflammation.
Reviewer's report
 Melatonin reduces cytokine induced expression of MAdCAM-1: Implications for IBD therapy. Title:
Authors:
Makotoh Sasaki MD (msasak@lsuhsc.edu )
Paul Jordan MD (pjorda1@lsuhsc.edu )
Takashi Joh MD (jalexa@lsuhsc.edu )
Makotoh Itoh MD (jalexa@lsuhsc.edu )
Michael Jenkins (michael.jenkins@virgin.net )
Kevin Pavlick PhD (kpavli@lsuhsc.edu )
Alireza Minagar MD (kaminag@lsuhsc.edu )
J Steven Alexander PhD (jalexa@lsuhsc.edu )
 4  9 Apr 2002 Version: Date:
 Wayne Patton Reviewer:
 A paper whose findings are important to those with closely related research interests Level of interest:
 Reject Advice on publication:
The revised manuscript was for the most part unresponsive to the reviewer's 
previous critique. Compulsory revisions 3 and 5-10 were not addressed in the 
revised manuscript. Criticism 4 was only partially addressed, it is important 
to explicitly state that the cell line is "an SV-40 transformed mouse lymphoid 
endothelial cell line". None of the other compulsory corrections were made at 
all. Without incorporation of the changes outlined in the previous review, I 
strongly recommend rejection of the manuscript. 
Competing interests:
The reviewer has no financial competing interests with regard to the paper. From 1987-1989, the 
reviewer did serve in the same academic laboratory as the senior author of the paper. This laboratory 
investigated cytoskeletal regulation of endothelial cell inflammation.
Please review this paper.
user
Reviewer's report
 Melatonin reduces cytokine induced expression of MAdCAM-1: Implications for IBD therapy. Title:
Authors:
Makotoh Sasaki MD (msasak@lsuhsc.edu )
Paul Jordan MD (pjorda1@lsuhsc.edu )
Takashi Joh MD (jalexa@lsuhsc.edu )
Makotoh Itoh MD (jalexa@lsuhsc.edu )
Michael Jenkins (michael.jenkins@virgin.net )
Kevin Pavlick PhD (kpavli@lsuhsc.edu )
Alireza Minagar MD (kaminag@lsuhsc.edu )
J Steven Alexander PhD (jalexa@lsuhsc.edu )
 4  9 Apr 2002 Version: Date:
 Wayne Patton Reviewer:
 A paper whose findings are important to those with closely related research interests Level of interest:
 Reject Advice on publication:
The revised manuscript was for the most part unresponsive to the reviewer's 
previous critique. Compulsory revisions 3 and 5-10 were not addressed in the 
revised manuscript. Criticism 4 was only partially addressed, it is important 
to explicitly state that the cell line is "an SV-40 transformed mouse lymphoid 
endothelial cell line". None of the other compulsory corrections were made at 
all. Without incorporation of the changes outlined in the previous review, I 
strongly recommend rejection of the manuscript. 
Competing interests:
The reviewer has no financial competing interests with regard to the paper. From 1987-1989, the 
reviewer did serve in the same academic laboratory as the senior author of the paper. This laboratory 
investigated cytoskeletal regulation of endothelial cell inflammation.
assistant