Title: Magnetic-Controlled Capsule Endoscopy Performance in Aging Patients
Version: 3 Date: 25 Jul 2023
Reviewer's report:
We thank the authors for taking the time to review and address our comments, we feel this has
improved the manuscript. However, there are a couple of points remaining.
1. The wrong paragraph has been removed in response to comment 5. The following was in the
original manuscript (lines 218-223) and is relevant:
In this retrospective study, MCE procedures of the interested oldest-old patients have
been reviewed. This is the first study assessed transit time and gastric visualization and
cleanliness scores in oldest-old patients compared with middle-old patients. Meantime, this
study demonstrated that the MCE could be a feasible and safe method of non-invasive
gastrointestinal examination for oldest-old patients. Another strength of this study was the
extended age field to 100 years old.
The text in the original manuscript that does not make sense in the context of the discussion
remains in the updated manuscript  (Lines 274-278)  and we feel this should be removed (see
below):
Age-related neurodegenerative functional changes in the enteric nervous system were reported
in rodents[16, 17]. Neuronal populations decreased mainly within the colon but also in the
esophagus, stomach, and small bowel[16, 18]. Moreover, the releasable pools of acetylcholine
and nNOS in the myenteric plexus [19] were reduced.
2.  The conclusion requires amending for clarity. The use of the term "older patients" twice is
confusing as earlier in the manuscript "older" has been used to define those aged 60-80years,
when the results show the conclusion to be indicated in those who are "oldest" >80 years. (see
below)
This retrospective study compared transit times and gastric preparation between patients over
80 years and patients 60–80 years old. We confirmed the benefits and safety of MCE for
older patients. For older patients with gastrointestinal diseases and poor motility, the gastric
examination may take longer and strategies for better gastric visibility should be considered.
Title: Magnetic-Controlled Capsule Endoscopy Performance in Aging Patients
Version: 3 Date: 25 Jul 2023
Reviewer's report:
We thank the authors for taking the time to review and address our comments, we feel this has
improved the manuscript. However, there are a couple of points remaining.
1. The wrong paragraph has been removed in response to comment 5. The following was in the
original manuscript (lines 218-223) and is relevant:
In this retrospective study, MCE procedures of the interested oldest-old patients have
been reviewed. This is the first study assessed transit time and gastric visualization and
cleanliness scores in oldest-old patients compared with middle-old patients. Meantime, this
study demonstrated that the MCE could be a feasible and safe method of non-invasive
gastrointestinal examination for oldest-old patients. Another strength of this study was the
extended age field to 100 years old.
The text in the original manuscript that does not make sense in the context of the discussion
remains in the updated manuscript  (Lines 274-278)  and we feel this should be removed (see
below):
Age-related neurodegenerative functional changes in the enteric nervous system were reported
in rodents[16, 17]. Neuronal populations decreased mainly within the colon but also in the
esophagus, stomach, and small bowel[16, 18]. Moreover, the releasable pools of acetylcholine
and nNOS in the myenteric plexus [19] were reduced.
2.  The conclusion requires amending for clarity. The use of the term "older patients" twice is
confusing as earlier in the manuscript "older" has been used to define those aged 60-80years,
when the results show the conclusion to be indicated in those who are "oldest" >80 years. (see
below)
This retrospective study compared transit times and gastric preparation between patients over
80 years and patients 60–80 years old. We confirmed the benefits and safety of MCE for
older patients. For older patients with gastrointestinal diseases and poor motility, the gastric
examination may take longer and strategies for better gastric visibility should be considered.
Please review this paper.
user
Title: Magnetic-Controlled Capsule Endoscopy Performance in Aging Patients
Version: 3 Date: 25 Jul 2023
Reviewer's report:
We thank the authors for taking the time to review and address our comments, we feel this has
improved the manuscript. However, there are a couple of points remaining.
1. The wrong paragraph has been removed in response to comment 5. The following was in the
original manuscript (lines 218-223) and is relevant:
In this retrospective study, MCE procedures of the interested oldest-old patients have
been reviewed. This is the first study assessed transit time and gastric visualization and
cleanliness scores in oldest-old patients compared with middle-old patients. Meantime, this
study demonstrated that the MCE could be a feasible and safe method of non-invasive
gastrointestinal examination for oldest-old patients. Another strength of this study was the
extended age field to 100 years old.
The text in the original manuscript that does not make sense in the context of the discussion
remains in the updated manuscript  (Lines 274-278)  and we feel this should be removed (see
below):
Age-related neurodegenerative functional changes in the enteric nervous system were reported
in rodents[16, 17]. Neuronal populations decreased mainly within the colon but also in the
esophagus, stomach, and small bowel[16, 18]. Moreover, the releasable pools of acetylcholine
and nNOS in the myenteric plexus [19] were reduced.
2.  The conclusion requires amending for clarity. The use of the term "older patients" twice is
confusing as earlier in the manuscript "older" has been used to define those aged 60-80years,
when the results show the conclusion to be indicated in those who are "oldest" >80 years. (see
below)
This retrospective study compared transit times and gastric preparation between patients over
80 years and patients 60–80 years old. We confirmed the benefits and safety of MCE for
older patients. For older patients with gastrointestinal diseases and poor motility, the gastric
examination may take longer and strategies for better gastric visibility should be considered.
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