Reviewer's report
Title:Effect of 5-HT7 receptor blockade on liver regeneration after 60-70% partial
hepatectomy
Version:4Date:11 April 2014
Reviewer: Vincenzo La Mura
Reviewer's report:
The manuscript describes an experimental study aimed at determining the effect
of 5-HT7 receptor blockade on liver regeneration after partial hepatectomy. The
design is coherent with the original aim. The results are in accordance with the
hypothesis however, in my opinion, other experiments, if possible, should be
performed in order to reinforce the evidence on the biological role played by this
receptor on liver regeneration.
Major Compulsory Revisions
Are there any pharmacological strategies that can be used in order to show that
the activation of the cascade by an alternative pathway allows to reverse the
biological effect of the antagonist? If so, I suggest to add this kind of experiment
that sensibly reinforce the evidence of the final message.
Minor Essential Revisions
The experiment with the inverse agonist of 5-HT7 receptor (SB-258719) should
be presented in the result paragraph rather than in the discussion.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Effect of 5-HT7 receptor blockade on liver regeneration after 60-70% partial
hepatectomy
Version:4Date:11 April 2014
Reviewer: Vincenzo La Mura
Reviewer's report:
The manuscript describes an experimental study aimed at determining the effect
of 5-HT7 receptor blockade on liver regeneration after partial hepatectomy. The
design is coherent with the original aim. The results are in accordance with the
hypothesis however, in my opinion, other experiments, if possible, should be
performed in order to reinforce the evidence on the biological role played by this
receptor on liver regeneration.
Major Compulsory Revisions
Are there any pharmacological strategies that can be used in order to show that
the activation of the cascade by an alternative pathway allows to reverse the
biological effect of the antagonist? If so, I suggest to add this kind of experiment
that sensibly reinforce the evidence of the final message.
Minor Essential Revisions
The experiment with the inverse agonist of 5-HT7 receptor (SB-258719) should
be presented in the result paragraph rather than in the discussion.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Effect of 5-HT7 receptor blockade on liver regeneration after 60-70% partial
hepatectomy
Version:4Date:11 April 2014
Reviewer: Vincenzo La Mura
Reviewer's report:
The manuscript describes an experimental study aimed at determining the effect
of 5-HT7 receptor blockade on liver regeneration after partial hepatectomy. The
design is coherent with the original aim. The results are in accordance with the
hypothesis however, in my opinion, other experiments, if possible, should be
performed in order to reinforce the evidence on the biological role played by this
receptor on liver regeneration.
Major Compulsory Revisions
Are there any pharmacological strategies that can be used in order to show that
the activation of the cascade by an alternative pathway allows to reverse the
biological effect of the antagonist? If so, I suggest to add this kind of experiment
that sensibly reinforce the evidence of the final message.
Minor Essential Revisions
The experiment with the inverse agonist of 5-HT7 receptor (SB-258719) should
be presented in the result paragraph rather than in the discussion.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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