Title: Impact of chemoradiotherapy on the survival of unresectable locally advanced pancreatic
cancer: A retrospective cohort analysis
Version: 2 Date: 15 Feb 2023
Reviewer:  Kenjiro Okada
Reviewer's report:
The manuscript titled " Impact of chemoradiotherapy on the survival of unresectable locally
advanced pancreatic cancer: a retrospective cohort analysis" highlights the survival benefits of
chemoradiotherapy for unresectable locally advanced pancreatic cancer patients according to
the results of univariate and multivariate Cox regression analysis and propensity score matching
analysis.
The manuscript is well written and balanced in its discussion. I have several questions.
1. In the enrolled patients, were there patients with new metastatic lesions during chemotherapy
or chemoradiotherapy?
2. In the future problem, do you intend to perform conversion surgery for locally advanced
patients with good response? If so, you describe the indication of conversion surgery for locally
advanced patients.
3. Tumor marker status including CA19-9 is highly associated with prognosis of PDAC patients.
Why did you not include the pretreatment tumor marker status in univariate or multivariate
overall analysis?
Title: Impact of chemoradiotherapy on the survival of unresectable locally advanced pancreatic
cancer: A retrospective cohort analysis
Version: 2 Date: 15 Feb 2023
Reviewer:  Kenjiro Okada
Reviewer's report:
The manuscript titled " Impact of chemoradiotherapy on the survival of unresectable locally
advanced pancreatic cancer: a retrospective cohort analysis" highlights the survival benefits of
chemoradiotherapy for unresectable locally advanced pancreatic cancer patients according to
the results of univariate and multivariate Cox regression analysis and propensity score matching
analysis.
The manuscript is well written and balanced in its discussion. I have several questions.
1. In the enrolled patients, were there patients with new metastatic lesions during chemotherapy
or chemoradiotherapy?
2. In the future problem, do you intend to perform conversion surgery for locally advanced
patients with good response? If so, you describe the indication of conversion surgery for locally
advanced patients.
3. Tumor marker status including CA19-9 is highly associated with prognosis of PDAC patients.
Why did you not include the pretreatment tumor marker status in univariate or multivariate
overall analysis?
Please review this paper.
user
Title: Impact of chemoradiotherapy on the survival of unresectable locally advanced pancreatic
cancer: A retrospective cohort analysis
Version: 2 Date: 15 Feb 2023
Reviewer:  Kenjiro Okada
Reviewer's report:
The manuscript titled " Impact of chemoradiotherapy on the survival of unresectable locally
advanced pancreatic cancer: a retrospective cohort analysis" highlights the survival benefits of
chemoradiotherapy for unresectable locally advanced pancreatic cancer patients according to
the results of univariate and multivariate Cox regression analysis and propensity score matching
analysis.
The manuscript is well written and balanced in its discussion. I have several questions.
1. In the enrolled patients, were there patients with new metastatic lesions during chemotherapy
or chemoradiotherapy?
2. In the future problem, do you intend to perform conversion surgery for locally advanced
patients with good response? If so, you describe the indication of conversion surgery for locally
advanced patients.
3. Tumor marker status including CA19-9 is highly associated with prognosis of PDAC patients.
Why did you not include the pretreatment tumor marker status in univariate or multivariate
overall analysis?
assistant