Reviewer's report
Title:Co-occurrence of IBS and symptoms of anxiety or depression, among
Norwegian twins, is influenced by both heredity and intrauterine growth
Version:2Date:15 October 2014
Reviewer: Oreste PIeramico
Reviewer's report:
This study deals with the hypothesis that intrauterine and genetic factors may
influence the co-occurrence of IBS and symptoms of anxiety and depression.
The authors, who have already large experience in that field of research, studied
a population of Norwegian twins assessing symptoms by means of appropriate
self-reported questionnaire responses.
I have no major objections about this paper: the subject of the study is very
important and of interest in the field of a better understanding of the central
mechanisms underlying disfunctions of the brain-gut axis; the hypothesis is well
formulated and the investigation is well conducted. The number of investigated
subjects as well the analysis of data is appropriate. Finally, the discussion is well
focused on data and on results of previous studies.
Minor revisions:
The authors should check if data reported on Table 1 are concordant with data
exposed in Materials and methods (page 4, lines 65-70)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Co-occurrence of IBS and symptoms of anxiety or depression, among
Norwegian twins, is influenced by both heredity and intrauterine growth
Version:2Date:15 October 2014
Reviewer: Oreste PIeramico
Reviewer's report:
This study deals with the hypothesis that intrauterine and genetic factors may
influence the co-occurrence of IBS and symptoms of anxiety and depression.
The authors, who have already large experience in that field of research, studied
a population of Norwegian twins assessing symptoms by means of appropriate
self-reported questionnaire responses.
I have no major objections about this paper: the subject of the study is very
important and of interest in the field of a better understanding of the central
mechanisms underlying disfunctions of the brain-gut axis; the hypothesis is well
formulated and the investigation is well conducted. The number of investigated
subjects as well the analysis of data is appropriate. Finally, the discussion is well
focused on data and on results of previous studies.
Minor revisions:
The authors should check if data reported on Table 1 are concordant with data
exposed in Materials and methods (page 4, lines 65-70)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Co-occurrence of IBS and symptoms of anxiety or depression, among
Norwegian twins, is influenced by both heredity and intrauterine growth
Version:2Date:15 October 2014
Reviewer: Oreste PIeramico
Reviewer's report:
This study deals with the hypothesis that intrauterine and genetic factors may
influence the co-occurrence of IBS and symptoms of anxiety and depression.
The authors, who have already large experience in that field of research, studied
a population of Norwegian twins assessing symptoms by means of appropriate
self-reported questionnaire responses.
I have no major objections about this paper: the subject of the study is very
important and of interest in the field of a better understanding of the central
mechanisms underlying disfunctions of the brain-gut axis; the hypothesis is well
formulated and the investigation is well conducted. The number of investigated
subjects as well the analysis of data is appropriate. Finally, the discussion is well
focused on data and on results of previous studies.
Minor revisions:
The authors should check if data reported on Table 1 are concordant with data
exposed in Materials and methods (page 4, lines 65-70)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant