Title: Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for
patients with hepatocellular carcinoma
Version: 4 Date: 28 Sep 2021
Reviewer's report:
Very well written manuscript.
I suggest to add a brief comment in the introduction or discussion on hepatocarcinogenesis
arising from NAFLD progression. On this regard, cite the study:
PMID: 29220698
Likewise, add a brief comment on hepatocarcinogenesis in diabetic patients. In this regard, cite
the study: PMID: 23845075
Finally, comment potential implications on molecular mechanisms in anticancer therapy for
HCC. In this regard, cite the studies: PMID: 25974743; PMID: 25915713; PMID: 25085684
Title: Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for
patients with hepatocellular carcinoma
Version: 4 Date: 28 Sep 2021
Reviewer's report:
Very well written manuscript.
I suggest to add a brief comment in the introduction or discussion on hepatocarcinogenesis
arising from NAFLD progression. On this regard, cite the study:
PMID: 29220698
Likewise, add a brief comment on hepatocarcinogenesis in diabetic patients. In this regard, cite
the study: PMID: 23845075
Finally, comment potential implications on molecular mechanisms in anticancer therapy for
HCC. In this regard, cite the studies: PMID: 25974743; PMID: 25915713; PMID: 25085684
Please review this paper.
user
Title: Clinical implications and molecular mechanisms of Cyclin-dependent kinases 4 for
patients with hepatocellular carcinoma
Version: 4 Date: 28 Sep 2021
Reviewer's report:
Very well written manuscript.
I suggest to add a brief comment in the introduction or discussion on hepatocarcinogenesis
arising from NAFLD progression. On this regard, cite the study:
PMID: 29220698
Likewise, add a brief comment on hepatocarcinogenesis in diabetic patients. In this regard, cite
the study: PMID: 23845075
Finally, comment potential implications on molecular mechanisms in anticancer therapy for
HCC. In this regard, cite the studies: PMID: 25974743; PMID: 25915713; PMID: 25085684
assistant