Reviewer's report
Title:Ferritin for the diagnosis of gastrointestinal cancer in patients with
involuntary weight loss
Version: 1Date:20 January 2012
Reviewer: Stefan Lindgren
Reviewer's report:
Major compulsory revisions
1. The ferritin level is influenced also by inflammation and alcohol. CPR has been
measured according to the Methods section, but the results are not presented or
discussed in relation to ferritin data. This must be done, particularly in relation to
inflammation. How many patients had elevated CRP? What was the situtation in
those patients with Ferritin >100? Are the conclusions still valid if the
contributions from inflammation and alcohol are included or if patients with active
inflammation are excluded?
2. The number of patients that had both upper and lower endoscopy should be
clearly stated also in the text - can be concluded from Fig 1.
3, The titel could be more informative. Maybe "Ferritin above 100 mcg/L rule out
colon cancer in patients with involuntary weight loss."
Minor essential revisions
1. Explain the meaning of "hospital work-up" Under "Patient inclusion," paragraph
2.
2. Figure 2 may not be needed
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Ferritin for the diagnosis of gastrointestinal cancer in patients with
involuntary weight loss
Version: 1Date:20 January 2012
Reviewer: Stefan Lindgren
Reviewer's report:
Major compulsory revisions
1. The ferritin level is influenced also by inflammation and alcohol. CPR has been
measured according to the Methods section, but the results are not presented or
discussed in relation to ferritin data. This must be done, particularly in relation to
inflammation. How many patients had elevated CRP? What was the situtation in
those patients with Ferritin >100? Are the conclusions still valid if the
contributions from inflammation and alcohol are included or if patients with active
inflammation are excluded?
2. The number of patients that had both upper and lower endoscopy should be
clearly stated also in the text - can be concluded from Fig 1.
3, The titel could be more informative. Maybe "Ferritin above 100 mcg/L rule out
colon cancer in patients with involuntary weight loss."
Minor essential revisions
1. Explain the meaning of "hospital work-up" Under "Patient inclusion," paragraph
2.
2. Figure 2 may not be needed
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Ferritin for the diagnosis of gastrointestinal cancer in patients with
involuntary weight loss
Version: 1Date:20 January 2012
Reviewer: Stefan Lindgren
Reviewer's report:
Major compulsory revisions
1. The ferritin level is influenced also by inflammation and alcohol. CPR has been
measured according to the Methods section, but the results are not presented or
discussed in relation to ferritin data. This must be done, particularly in relation to
inflammation. How many patients had elevated CRP? What was the situtation in
those patients with Ferritin >100? Are the conclusions still valid if the
contributions from inflammation and alcohol are included or if patients with active
inflammation are excluded?
2. The number of patients that had both upper and lower endoscopy should be
clearly stated also in the text - can be concluded from Fig 1.
3, The titel could be more informative. Maybe "Ferritin above 100 mcg/L rule out
colon cancer in patients with involuntary weight loss."
Minor essential revisions
1. Explain the meaning of "hospital work-up" Under "Patient inclusion," paragraph
2.
2. Figure 2 may not be needed
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
assistant