Title: Efficacy and safety of heparin plus dexamethasone after partial splenic embolization for
liver cirrhosis with massive splenomegaly
Version: 3 Date: 02 Oct 2022
Reviewer:  Jin-hui Yang
Reviewer's report:
I appreciate the opportunity to review this manuscript. The authors conducted a case-control
study of the Efficacy and safety of heparin plus dexamethasone after PSE for liver cirrhosis with
massive splenomegaly. As expected, the PSE+Hep+DEX group was  effective  and having the
higher safety. While these findings are not novel, there are no major methodologic issues that
I could find.
Comments:
1. The authors used volume software within Siemens CT workstation to calculate  the volume
of splenic embolism area and embolization rate, and  Imaging examination to reexamine after
operation,  but I could not find any related imaging evidence. Recommend to supplement
relevant imaging evidence.
2. The author used the T test when analyzing the measurement data, but only the  data conforms
to the normal distribution is suitable for the T test. Recommended to supplement  the validation
of normal distribution.
3. Why the number of PLT in the PSE+Hep+DEX group was higher than that in the PSE group
at one week and one month after treatment? I could not find this in the discussion section.
Title: Efficacy and safety of heparin plus dexamethasone after partial splenic embolization for
liver cirrhosis with massive splenomegaly
Version: 3 Date: 02 Oct 2022
Reviewer:  Jin-hui Yang
Reviewer's report:
I appreciate the opportunity to review this manuscript. The authors conducted a case-control
study of the Efficacy and safety of heparin plus dexamethasone after PSE for liver cirrhosis with
massive splenomegaly. As expected, the PSE+Hep+DEX group was  effective  and having the
higher safety. While these findings are not novel, there are no major methodologic issues that
I could find.
Comments:
1. The authors used volume software within Siemens CT workstation to calculate  the volume
of splenic embolism area and embolization rate, and  Imaging examination to reexamine after
operation,  but I could not find any related imaging evidence. Recommend to supplement
relevant imaging evidence.
2. The author used the T test when analyzing the measurement data, but only the  data conforms
to the normal distribution is suitable for the T test. Recommended to supplement  the validation
of normal distribution.
3. Why the number of PLT in the PSE+Hep+DEX group was higher than that in the PSE group
at one week and one month after treatment? I could not find this in the discussion section.
Please review this paper.
user
Title: Efficacy and safety of heparin plus dexamethasone after partial splenic embolization for
liver cirrhosis with massive splenomegaly
Version: 3 Date: 02 Oct 2022
Reviewer:  Jin-hui Yang
Reviewer's report:
I appreciate the opportunity to review this manuscript. The authors conducted a case-control
study of the Efficacy and safety of heparin plus dexamethasone after PSE for liver cirrhosis with
massive splenomegaly. As expected, the PSE+Hep+DEX group was  effective  and having the
higher safety. While these findings are not novel, there are no major methodologic issues that
I could find.
Comments:
1. The authors used volume software within Siemens CT workstation to calculate  the volume
of splenic embolism area and embolization rate, and  Imaging examination to reexamine after
operation,  but I could not find any related imaging evidence. Recommend to supplement
relevant imaging evidence.
2. The author used the T test when analyzing the measurement data, but only the  data conforms
to the normal distribution is suitable for the T test. Recommended to supplement  the validation
of normal distribution.
3. Why the number of PLT in the PSE+Hep+DEX group was higher than that in the PSE group
at one week and one month after treatment? I could not find this in the discussion section.
assistant