Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 1 Date: 20 Jun 2022
Reviewer:  Gilles R. G. Monif
Reviewer's report:
This is a  classically prepared manuscript that was  developed with care.
The authors ask a simple question and then proceed to answer it  with a small, but well
constructed experimental design. The data reinforces previously published  and cited data (Br.
J. Clin. Pharmacol. 2020.86;1296-1305).
Where it suffers is attempting  to be overly inclusive in orientating the reader to Crohn's
Disease. The introduction needs to be reworked with deletion of paragraphs three on and updated
discussion of the now documented  pathogenesis of Crohn's disease .
Crohn's disease is not an autoimmune disease, but an immune-mediated disease. Most of the
authors' corresponding references date to pathogenesis are dated.
A better introduction to their data is discussion of cytokine response as a critical component
of cellular immunity to organismal challenge or  as in the case of Crohn's disease,  antigen
challenges secondary to pre-set  fixation of the immune system's pro-inflammatory response
to Mycobacterium avium subspecies paratuberculosis (Med. Hypothesis 2015. 85,878-88;
Gastrointest. Discord. 2021, 3;138-141).
In the conclusion, the authors may want to speculated on the usefulness of cytokine monitoring
as a gage of therapeutic efficacy.
Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 1 Date: 20 Jun 2022
Reviewer:  Gilles R. G. Monif
Reviewer's report:
This is a  classically prepared manuscript that was  developed with care.
The authors ask a simple question and then proceed to answer it  with a small, but well
constructed experimental design. The data reinforces previously published  and cited data (Br.
J. Clin. Pharmacol. 2020.86;1296-1305).
Where it suffers is attempting  to be overly inclusive in orientating the reader to Crohn's
Disease. The introduction needs to be reworked with deletion of paragraphs three on and updated
discussion of the now documented  pathogenesis of Crohn's disease .
Crohn's disease is not an autoimmune disease, but an immune-mediated disease. Most of the
authors' corresponding references date to pathogenesis are dated.
A better introduction to their data is discussion of cytokine response as a critical component
of cellular immunity to organismal challenge or  as in the case of Crohn's disease,  antigen
challenges secondary to pre-set  fixation of the immune system's pro-inflammatory response
to Mycobacterium avium subspecies paratuberculosis (Med. Hypothesis 2015. 85,878-88;
Gastrointest. Discord. 2021, 3;138-141).
In the conclusion, the authors may want to speculated on the usefulness of cytokine monitoring
as a gage of therapeutic efficacy.
Please review this paper.
user
Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 1 Date: 20 Jun 2022
Reviewer:  Gilles R. G. Monif
Reviewer's report:
This is a  classically prepared manuscript that was  developed with care.
The authors ask a simple question and then proceed to answer it  with a small, but well
constructed experimental design. The data reinforces previously published  and cited data (Br.
J. Clin. Pharmacol. 2020.86;1296-1305).
Where it suffers is attempting  to be overly inclusive in orientating the reader to Crohn's
Disease. The introduction needs to be reworked with deletion of paragraphs three on and updated
discussion of the now documented  pathogenesis of Crohn's disease .
Crohn's disease is not an autoimmune disease, but an immune-mediated disease. Most of the
authors' corresponding references date to pathogenesis are dated.
A better introduction to their data is discussion of cytokine response as a critical component
of cellular immunity to organismal challenge or  as in the case of Crohn's disease,  antigen
challenges secondary to pre-set  fixation of the immune system's pro-inflammatory response
to Mycobacterium avium subspecies paratuberculosis (Med. Hypothesis 2015. 85,878-88;
Gastrointest. Discord. 2021, 3;138-141).
In the conclusion, the authors may want to speculated on the usefulness of cytokine monitoring
as a gage of therapeutic efficacy.
assistant