Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 2 Date: 02 Jan 2021
Reviewer's report:
This study explored the role of AKI in the prognosis of cirrhosis with acute variceal bleeding.
This subject is very important for clinical practice. But current study might have some flaws.
My comments regarding this work are as follows.
1. Was this study approved by the local ethics committee? If yes, please provide ethics number.
2. The sentence “The remaining 546 episodes in 390 patients with AVB were finally selected
for analysis (Figure 1).” should be included in the section of results.
3. As we all known, diabetes might be associated with the prognosis of cirrhosis with GIB
(PMID: 25874528 and PMID: 31512140). Can the author provide relevant data?
4. The diagnosis of ICA-AKI is defined as an increase of # 0.3 mg/dL during 48 hours or # 50%
over baseline in serum creatinine levels. The time frame is important for the diagnosis of ICA-
AKI. Please properly cite the diagnostic criteria.
5. How many patients were diagnosed AKI according to the conventional AKI criteria?
6. “Stage 1A and Stage 1a”. Please be consistent.
7. In this study, the different between ICA-AKI and conventional AKI in predict the mortality
of AVB should be detailed description.
8. Many grammatical errors which need revision by English native speaker.
Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 2 Date: 02 Jan 2021
Reviewer's report:
This study explored the role of AKI in the prognosis of cirrhosis with acute variceal bleeding.
This subject is very important for clinical practice. But current study might have some flaws.
My comments regarding this work are as follows.
1. Was this study approved by the local ethics committee? If yes, please provide ethics number.
2. The sentence “The remaining 546 episodes in 390 patients with AVB were finally selected
for analysis (Figure 1).” should be included in the section of results.
3. As we all known, diabetes might be associated with the prognosis of cirrhosis with GIB
(PMID: 25874528 and PMID: 31512140). Can the author provide relevant data?
4. The diagnosis of ICA-AKI is defined as an increase of # 0.3 mg/dL during 48 hours or # 50%
over baseline in serum creatinine levels. The time frame is important for the diagnosis of ICA-
AKI. Please properly cite the diagnostic criteria.
5. How many patients were diagnosed AKI according to the conventional AKI criteria?
6. “Stage 1A and Stage 1a”. Please be consistent.
7. In this study, the different between ICA-AKI and conventional AKI in predict the mortality
of AVB should be detailed description.
8. Many grammatical errors which need revision by English native speaker.
Please review this paper.
user
Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 2 Date: 02 Jan 2021
Reviewer's report:
This study explored the role of AKI in the prognosis of cirrhosis with acute variceal bleeding.
This subject is very important for clinical practice. But current study might have some flaws.
My comments regarding this work are as follows.
1. Was this study approved by the local ethics committee? If yes, please provide ethics number.
2. The sentence “The remaining 546 episodes in 390 patients with AVB were finally selected
for analysis (Figure 1).” should be included in the section of results.
3. As we all known, diabetes might be associated with the prognosis of cirrhosis with GIB
(PMID: 25874528 and PMID: 31512140). Can the author provide relevant data?
4. The diagnosis of ICA-AKI is defined as an increase of # 0.3 mg/dL during 48 hours or # 50%
over baseline in serum creatinine levels. The time frame is important for the diagnosis of ICA-
AKI. Please properly cite the diagnostic criteria.
5. How many patients were diagnosed AKI according to the conventional AKI criteria?
6. “Stage 1A and Stage 1a”. Please be consistent.
7. In this study, the different between ICA-AKI and conventional AKI in predict the mortality
of AVB should be detailed description.
8. Many grammatical errors which need revision by English native speaker.
assistant