Title: Efficacy and safety of tacrolimus in older adults with ulcerative colitis: A retrospective
study
Version: 3 Date: 02 Nov 2023
Reviewer:  Saurabh Dawra
Reviewer's report:
The authors have chosen a novel and niche aspect of UC management However, a few queries
require arise
1 kindly describe in brief , your institutes management protocol for management of UC
especially steroid refractory UC
2 How do you decide to give Tacrolimus instead of Cyclosporine/ TNF Alpha inhibitors
3 When do you initiate Tacrolimus in patients? What is your dosing schedule: Intravenous or oral
4 How many patients underwent colectomy after tacrolimus therapy vs non tacrolimus group
5 Does Tacrolimus therapy increase ris of infections in the two groups is there any data available
on this aspect
6 Why have you chosen to describe ASA allergy Is it related to response to Tacrolimus therapy
in any way
7 More patients in younger group have biological exposure as compared to elder group? Has
this affected the disease response in any way kindly elaborate
Title: Efficacy and safety of tacrolimus in older adults with ulcerative colitis: A retrospective
study
Version: 3 Date: 02 Nov 2023
Reviewer:  Saurabh Dawra
Reviewer's report:
The authors have chosen a novel and niche aspect of UC management However, a few queries
require arise
1 kindly describe in brief , your institutes management protocol for management of UC
especially steroid refractory UC
2 How do you decide to give Tacrolimus instead of Cyclosporine/ TNF Alpha inhibitors
3 When do you initiate Tacrolimus in patients? What is your dosing schedule: Intravenous or oral
4 How many patients underwent colectomy after tacrolimus therapy vs non tacrolimus group
5 Does Tacrolimus therapy increase ris of infections in the two groups is there any data available
on this aspect
6 Why have you chosen to describe ASA allergy Is it related to response to Tacrolimus therapy
in any way
7 More patients in younger group have biological exposure as compared to elder group? Has
this affected the disease response in any way kindly elaborate
Please review this paper.
user
Title: Efficacy and safety of tacrolimus in older adults with ulcerative colitis: A retrospective
study
Version: 3 Date: 02 Nov 2023
Reviewer:  Saurabh Dawra
Reviewer's report:
The authors have chosen a novel and niche aspect of UC management However, a few queries
require arise
1 kindly describe in brief , your institutes management protocol for management of UC
especially steroid refractory UC
2 How do you decide to give Tacrolimus instead of Cyclosporine/ TNF Alpha inhibitors
3 When do you initiate Tacrolimus in patients? What is your dosing schedule: Intravenous or oral
4 How many patients underwent colectomy after tacrolimus therapy vs non tacrolimus group
5 Does Tacrolimus therapy increase ris of infections in the two groups is there any data available
on this aspect
6 Why have you chosen to describe ASA allergy Is it related to response to Tacrolimus therapy
in any way
7 More patients in younger group have biological exposure as compared to elder group? Has
this affected the disease response in any way kindly elaborate
assistant