Title: A New Prediction Model of Hepatocellular Carcinoma Based on N7-methylguanosine
Modification
Version: 4 Date: 17 Feb 2023
Reviewer's report:
The paper named “A New Prediction Model of Hepatocellular Carcinoma Based on N7-
methylguanosine Modification” conducted by Yang et al. has been evaluated. I think this study
has certain innovation and clinical significance. In this study, the author identified a novel
lncRNAs signature associated with m7G predicts the prognosis of HCC. However, some obvious
limitations impair the overall quality. Before it is suitable for publication, I suggest the author
make substantive modifications.
1. However, I noticed that some of the figures have a low resolution which makes them hard
to read. I would suggest that the authors increase the resolution of these figures, which would
make them easier to read and understand. This would also make it easier for readers to fully
understand the results and make use of it. I believe that increasing the resolution of these figures
would greatly improve the manuscript.
2. Some previous studies have used similar methods. Although it will lose some innovation, I
think it will benefit the reader if the authors could include the following references, which would
provide readers with a more complete understanding of the whole study (PMID: 33850225,
PMID: 34099740, PMID: 33148208 ...). Meanwhile, the introduction part should be improved
by refering to the following studies (PMID: 32474508, PMID: 32474508).
3. Detailed description of all sections is required.
4. State the * and statistic value in the method section or otherwise mention in every figure
legend. e.g., *p>0.05.
5. Check the reference style and abbreviation of journals.
6. Some typos are there; rectify those (Minor).
7. The relationship between immune cell infiltration and specific pathways should be well
discussed in the relevant section.
Title: A New Prediction Model of Hepatocellular Carcinoma Based on N7-methylguanosine
Modification
Version: 4 Date: 17 Feb 2023
Reviewer's report:
The paper named “A New Prediction Model of Hepatocellular Carcinoma Based on N7-
methylguanosine Modification” conducted by Yang et al. has been evaluated. I think this study
has certain innovation and clinical significance. In this study, the author identified a novel
lncRNAs signature associated with m7G predicts the prognosis of HCC. However, some obvious
limitations impair the overall quality. Before it is suitable for publication, I suggest the author
make substantive modifications.
1. However, I noticed that some of the figures have a low resolution which makes them hard
to read. I would suggest that the authors increase the resolution of these figures, which would
make them easier to read and understand. This would also make it easier for readers to fully
understand the results and make use of it. I believe that increasing the resolution of these figures
would greatly improve the manuscript.
2. Some previous studies have used similar methods. Although it will lose some innovation, I
think it will benefit the reader if the authors could include the following references, which would
provide readers with a more complete understanding of the whole study (PMID: 33850225,
PMID: 34099740, PMID: 33148208 ...). Meanwhile, the introduction part should be improved
by refering to the following studies (PMID: 32474508, PMID: 32474508).
3. Detailed description of all sections is required.
4. State the * and statistic value in the method section or otherwise mention in every figure
legend. e.g., *p>0.05.
5. Check the reference style and abbreviation of journals.
6. Some typos are there; rectify those (Minor).
7. The relationship between immune cell infiltration and specific pathways should be well
discussed in the relevant section.
Please review this paper.
user
Title: A New Prediction Model of Hepatocellular Carcinoma Based on N7-methylguanosine
Modification
Version: 4 Date: 17 Feb 2023
Reviewer's report:
The paper named “A New Prediction Model of Hepatocellular Carcinoma Based on N7-
methylguanosine Modification” conducted by Yang et al. has been evaluated. I think this study
has certain innovation and clinical significance. In this study, the author identified a novel
lncRNAs signature associated with m7G predicts the prognosis of HCC. However, some obvious
limitations impair the overall quality. Before it is suitable for publication, I suggest the author
make substantive modifications.
1. However, I noticed that some of the figures have a low resolution which makes them hard
to read. I would suggest that the authors increase the resolution of these figures, which would
make them easier to read and understand. This would also make it easier for readers to fully
understand the results and make use of it. I believe that increasing the resolution of these figures
would greatly improve the manuscript.
2. Some previous studies have used similar methods. Although it will lose some innovation, I
think it will benefit the reader if the authors could include the following references, which would
provide readers with a more complete understanding of the whole study (PMID: 33850225,
PMID: 34099740, PMID: 33148208 ...). Meanwhile, the introduction part should be improved
by refering to the following studies (PMID: 32474508, PMID: 32474508).
3. Detailed description of all sections is required.
4. State the * and statistic value in the method section or otherwise mention in every figure
legend. e.g., *p>0.05.
5. Check the reference style and abbreviation of journals.
6. Some typos are there; rectify those (Minor).
7. The relationship between immune cell infiltration and specific pathways should be well
discussed in the relevant section.
assistant