Title: Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer
over age 80: a retrospective study
Version: 2 Date: 09 Mar 2021
Reviewer's report:
Thanks for the opportunity to review the manuscript about the prognostic analysis of super-
elderly metastatic colorectal cancer. There are some issues needed to be addressed.
1. The study enrolled the patient diagnosed between January 2012 and December 2016 and the
medical records were analyzed until August 2019. If the authors want to analyze the 3-years
survival, the study duration should be extended to Dec 2019 at least.
2. In table 1, and table 5a/b, should the description of "Poorly differentiated cancer and signet-
ring cell carcinoma" be "Poorly differentiated cancer or signet-ring cell carcinoma “?
3. In the result, line 221, the authors mentioned " ...... a similar trend was noted for patients
with PNI > 35 (18.5 vs. 12.9 months; P = 0.64)......." and in the discussion, line 283, the authors
mentioned "As shown in Figure 4b, there is a possibility that chemotherapy may be useful even
in patients with a high level of PNI......" However, there is no statistical difference or even a
trend shown in the figure 4b. The authors should make some modifications.
4. Although in the result, the authors mentioned that " super-elderly patients receiving mono-
chemotherapy (n = 2) did not report any grade 3 or 4 adverse events ", there is no enough
evidence that the authors could conclude that combination chemotherapy based on oxaliplatin
may exceed the treatment limit for super-elderly patients.
5. There are some typos, such as:
table 2, "Resction" of primary tumor -> "Resection"......
page 17, line 210, The 1- and 3-year OS in the in the younger group were...... -> ...... OS in the
younger ......
Title: Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer
over age 80: a retrospective study
Version: 2 Date: 09 Mar 2021
Reviewer's report:
Thanks for the opportunity to review the manuscript about the prognostic analysis of super-
elderly metastatic colorectal cancer. There are some issues needed to be addressed.
1. The study enrolled the patient diagnosed between January 2012 and December 2016 and the
medical records were analyzed until August 2019. If the authors want to analyze the 3-years
survival, the study duration should be extended to Dec 2019 at least.
2. In table 1, and table 5a/b, should the description of "Poorly differentiated cancer and signet-
ring cell carcinoma" be "Poorly differentiated cancer or signet-ring cell carcinoma “?
3. In the result, line 221, the authors mentioned " ...... a similar trend was noted for patients
with PNI > 35 (18.5 vs. 12.9 months; P = 0.64)......." and in the discussion, line 283, the authors
mentioned "As shown in Figure 4b, there is a possibility that chemotherapy may be useful even
in patients with a high level of PNI......" However, there is no statistical difference or even a
trend shown in the figure 4b. The authors should make some modifications.
4. Although in the result, the authors mentioned that " super-elderly patients receiving mono-
chemotherapy (n = 2) did not report any grade 3 or 4 adverse events ", there is no enough
evidence that the authors could conclude that combination chemotherapy based on oxaliplatin
may exceed the treatment limit for super-elderly patients.
5. There are some typos, such as:
table 2, "Resction" of primary tumor -> "Resection"......
page 17, line 210, The 1- and 3-year OS in the in the younger group were...... -> ...... OS in the
younger ......
Please review this paper.
user
Title: Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer
over age 80: a retrospective study
Version: 2 Date: 09 Mar 2021
Reviewer's report:
Thanks for the opportunity to review the manuscript about the prognostic analysis of super-
elderly metastatic colorectal cancer. There are some issues needed to be addressed.
1. The study enrolled the patient diagnosed between January 2012 and December 2016 and the
medical records were analyzed until August 2019. If the authors want to analyze the 3-years
survival, the study duration should be extended to Dec 2019 at least.
2. In table 1, and table 5a/b, should the description of "Poorly differentiated cancer and signet-
ring cell carcinoma" be "Poorly differentiated cancer or signet-ring cell carcinoma “?
3. In the result, line 221, the authors mentioned " ...... a similar trend was noted for patients
with PNI > 35 (18.5 vs. 12.9 months; P = 0.64)......." and in the discussion, line 283, the authors
mentioned "As shown in Figure 4b, there is a possibility that chemotherapy may be useful even
in patients with a high level of PNI......" However, there is no statistical difference or even a
trend shown in the figure 4b. The authors should make some modifications.
4. Although in the result, the authors mentioned that " super-elderly patients receiving mono-
chemotherapy (n = 2) did not report any grade 3 or 4 adverse events ", there is no enough
evidence that the authors could conclude that combination chemotherapy based on oxaliplatin
may exceed the treatment limit for super-elderly patients.
5. There are some typos, such as:
table 2, "Resction" of primary tumor -> "Resection"......
page 17, line 210, The 1- and 3-year OS in the in the younger group were...... -> ...... OS in the
younger ......
assistant