Title: Value of transrectal ultrasound guided biopsy in endoscopy negative biopsy patients with
rectal lesions
Version: 1 Date: 15 Feb 2023
Reviewer:  Thomas Togliani
Reviewer's report:
This is an interesting and original work about ultrasound-guided needle biopsies of rectal lesions
after an unrevealing endoscopic biopsy.
My remarks are:
1) the english language is a bit poor:
page 4: need (be needed)
page 4: has use (is used)
page 5: patients divided (patients were divided)
page 7: take (taking)
page 8: endoscopic (endoscopy)
2) the methods are questionable: I don't understand why the choice of using the contrast or not
depends on the conditions and the willing of the patient; I would have preferred a randomization
3) in the discussion lacks any mention or comparison to studies about the gold standards
after negative endoscopic biopsies, which are the repetition of endoscopic biopsies (in case of
epithelial lesions) or EUS-guided needle biopsies (is case of subepithelial lesions)
Title: Value of transrectal ultrasound guided biopsy in endoscopy negative biopsy patients with
rectal lesions
Version: 1 Date: 15 Feb 2023
Reviewer:  Thomas Togliani
Reviewer's report:
This is an interesting and original work about ultrasound-guided needle biopsies of rectal lesions
after an unrevealing endoscopic biopsy.
My remarks are:
1) the english language is a bit poor:
page 4: need (be needed)
page 4: has use (is used)
page 5: patients divided (patients were divided)
page 7: take (taking)
page 8: endoscopic (endoscopy)
2) the methods are questionable: I don't understand why the choice of using the contrast or not
depends on the conditions and the willing of the patient; I would have preferred a randomization
3) in the discussion lacks any mention or comparison to studies about the gold standards
after negative endoscopic biopsies, which are the repetition of endoscopic biopsies (in case of
epithelial lesions) or EUS-guided needle biopsies (is case of subepithelial lesions)
Please review this paper.
user
Title: Value of transrectal ultrasound guided biopsy in endoscopy negative biopsy patients with
rectal lesions
Version: 1 Date: 15 Feb 2023
Reviewer:  Thomas Togliani
Reviewer's report:
This is an interesting and original work about ultrasound-guided needle biopsies of rectal lesions
after an unrevealing endoscopic biopsy.
My remarks are:
1) the english language is a bit poor:
page 4: need (be needed)
page 4: has use (is used)
page 5: patients divided (patients were divided)
page 7: take (taking)
page 8: endoscopic (endoscopy)
2) the methods are questionable: I don't understand why the choice of using the contrast or not
depends on the conditions and the willing of the patient; I would have preferred a randomization
3) in the discussion lacks any mention or comparison to studies about the gold standards
after negative endoscopic biopsies, which are the repetition of endoscopic biopsies (in case of
epithelial lesions) or EUS-guided needle biopsies (is case of subepithelial lesions)
assistant