Title: Development and validation of a new predictive model for the immune tolerance stage of
chronic HBV infection based on the liver histopathological changes
Version: 4 Date: 30 Apr 2025
Reviewer's report:
While my comments and inquiries directed to the authors have been satisfactorily addressed,
the issues highlighted by the editor—specifically,
1) the potential selection bias associated with the liver biopsy-based study design, and
2) the applicability and validity of the semi-quantitative measurement of HBeAg levels—remain
to be thoroughly resolved.
Title: Development and validation of a new predictive model for the immune tolerance stage of
chronic HBV infection based on the liver histopathological changes
Version: 4 Date: 30 Apr 2025
Reviewer's report:
While my comments and inquiries directed to the authors have been satisfactorily addressed,
the issues highlighted by the editor—specifically,
1) the potential selection bias associated with the liver biopsy-based study design, and
2) the applicability and validity of the semi-quantitative measurement of HBeAg levels—remain
to be thoroughly resolved.
Please review this paper.
user
Title: Development and validation of a new predictive model for the immune tolerance stage of
chronic HBV infection based on the liver histopathological changes
Version: 4 Date: 30 Apr 2025
Reviewer's report:
While my comments and inquiries directed to the authors have been satisfactorily addressed,
the issues highlighted by the editor—specifically,
1) the potential selection bias associated with the liver biopsy-based study design, and
2) the applicability and validity of the semi-quantitative measurement of HBeAg levels—remain
to be thoroughly resolved.
assistant