Title: Global and Regional Burden of Pancreatitis: Epidemiological Trends, Risk Factors, and
Projections to 2050 from the Global Burden of Disease Study 2021
Version: 1 Date: 08 Oct 2024
Reviewer:  Anand Krishnan
Reviewer's report:
Overall, the paper addresses an important issue and is well written. Some suggestions to improve
it further.
1. As the authors accept, pancreatitis could be acute , recurrent or chronic. It is not clear
what is being studied here. For acute conditions we use incidence and for chronic we measure
prevalence. In this study it is not clear how these have been combined into an incidence estimate.
2. The paper needs to describe the sources of its data (which are core to the establish credibility
of the estimate along with statistical treatment). Are these cohorts, surveys, registries, hospital
based studies, insurance data etc.
3. Statistical treatment is also opaque as is true for most GBD papers and needs to be described
better as to how did they move from studies to regional and global estimates.
Title: Global and Regional Burden of Pancreatitis: Epidemiological Trends, Risk Factors, and
Projections to 2050 from the Global Burden of Disease Study 2021
Version: 1 Date: 08 Oct 2024
Reviewer:  Anand Krishnan
Reviewer's report:
Overall, the paper addresses an important issue and is well written. Some suggestions to improve
it further.
1. As the authors accept, pancreatitis could be acute , recurrent or chronic. It is not clear
what is being studied here. For acute conditions we use incidence and for chronic we measure
prevalence. In this study it is not clear how these have been combined into an incidence estimate.
2. The paper needs to describe the sources of its data (which are core to the establish credibility
of the estimate along with statistical treatment). Are these cohorts, surveys, registries, hospital
based studies, insurance data etc.
3. Statistical treatment is also opaque as is true for most GBD papers and needs to be described
better as to how did they move from studies to regional and global estimates.
Please review this paper.
user
Title: Global and Regional Burden of Pancreatitis: Epidemiological Trends, Risk Factors, and
Projections to 2050 from the Global Burden of Disease Study 2021
Version: 1 Date: 08 Oct 2024
Reviewer:  Anand Krishnan
Reviewer's report:
Overall, the paper addresses an important issue and is well written. Some suggestions to improve
it further.
1. As the authors accept, pancreatitis could be acute , recurrent or chronic. It is not clear
what is being studied here. For acute conditions we use incidence and for chronic we measure
prevalence. In this study it is not clear how these have been combined into an incidence estimate.
2. The paper needs to describe the sources of its data (which are core to the establish credibility
of the estimate along with statistical treatment). Are these cohorts, surveys, registries, hospital
based studies, insurance data etc.
3. Statistical treatment is also opaque as is true for most GBD papers and needs to be described
better as to how did they move from studies to regional and global estimates.
assistant