Title: Peptic ulcer characteristics in oral opium and non-opium user patients with upper
gastrointestinal bleeding
Version: 1 Date: 16 Jun 2023
Reviewer's report:
This manuscript by Mohsen Masoodi et al aimed to examine Peptic ulcer characteristics in
oral opium and non-opium user patients with upper gastrointestinal bleeding. The manuscript
contains new results. However, I have some serious concerns on several issues.
Major point
#Authors conclude that multiple, large peptic ulcers in GIB are potential complications of oral
opium use. In oral opium user, opium is used for medical use or for non-medical use? Moreover,
to clarify this conclusion, the detail data about opium (such as type, concentration, duration,
quantity and frequency…) is required.
#The ratio of woman in group 1(oral opium use) is larger than group 2(non- oral opium use),
and the mean age of group 1(oral opium use) may be younger than group 2(non- oral opium
use). Authors should discuss about the possibility that this difference influences a conclusion.
#Authors showed that esophageal ulcers were more common in group 1 (30%) than in group 2
(8%). Authors should show the endoscopic image and detail data of esophageal ulcer (such as
location(upper, middle, lower), type(reflux esophagitis?, ulcer) and size).
Minor point
#Authors should show the definition of oral opium use (inquiry and?/or? urine test?).
#Authors should add the more detail information of patient’s characteristics (Table 1) (such
as BMI, alcohol, smoking, comorbidities, opium (type, concentration, duration, quantity and
frequency)..) and should show the data of significant test (p-value) between group 1 and group 2.
#Discussion is too long for a result.
Title: Peptic ulcer characteristics in oral opium and non-opium user patients with upper
gastrointestinal bleeding
Version: 1 Date: 16 Jun 2023
Reviewer's report:
This manuscript by Mohsen Masoodi et al aimed to examine Peptic ulcer characteristics in
oral opium and non-opium user patients with upper gastrointestinal bleeding. The manuscript
contains new results. However, I have some serious concerns on several issues.
Major point
#Authors conclude that multiple, large peptic ulcers in GIB are potential complications of oral
opium use. In oral opium user, opium is used for medical use or for non-medical use? Moreover,
to clarify this conclusion, the detail data about opium (such as type, concentration, duration,
quantity and frequency…) is required.
#The ratio of woman in group 1(oral opium use) is larger than group 2(non- oral opium use),
and the mean age of group 1(oral opium use) may be younger than group 2(non- oral opium
use). Authors should discuss about the possibility that this difference influences a conclusion.
#Authors showed that esophageal ulcers were more common in group 1 (30%) than in group 2
(8%). Authors should show the endoscopic image and detail data of esophageal ulcer (such as
location(upper, middle, lower), type(reflux esophagitis?, ulcer) and size).
Minor point
#Authors should show the definition of oral opium use (inquiry and?/or? urine test?).
#Authors should add the more detail information of patient’s characteristics (Table 1) (such
as BMI, alcohol, smoking, comorbidities, opium (type, concentration, duration, quantity and
frequency)..) and should show the data of significant test (p-value) between group 1 and group 2.
#Discussion is too long for a result.
Please review this paper.
user
Title: Peptic ulcer characteristics in oral opium and non-opium user patients with upper
gastrointestinal bleeding
Version: 1 Date: 16 Jun 2023
Reviewer's report:
This manuscript by Mohsen Masoodi et al aimed to examine Peptic ulcer characteristics in
oral opium and non-opium user patients with upper gastrointestinal bleeding. The manuscript
contains new results. However, I have some serious concerns on several issues.
Major point
#Authors conclude that multiple, large peptic ulcers in GIB are potential complications of oral
opium use. In oral opium user, opium is used for medical use or for non-medical use? Moreover,
to clarify this conclusion, the detail data about opium (such as type, concentration, duration,
quantity and frequency…) is required.
#The ratio of woman in group 1(oral opium use) is larger than group 2(non- oral opium use),
and the mean age of group 1(oral opium use) may be younger than group 2(non- oral opium
use). Authors should discuss about the possibility that this difference influences a conclusion.
#Authors showed that esophageal ulcers were more common in group 1 (30%) than in group 2
(8%). Authors should show the endoscopic image and detail data of esophageal ulcer (such as
location(upper, middle, lower), type(reflux esophagitis?, ulcer) and size).
Minor point
#Authors should show the definition of oral opium use (inquiry and?/or? urine test?).
#Authors should add the more detail information of patient’s characteristics (Table 1) (such
as BMI, alcohol, smoking, comorbidities, opium (type, concentration, duration, quantity and
frequency)..) and should show the data of significant test (p-value) between group 1 and group 2.
#Discussion is too long for a result.
assistant