Title: Understanding the Adult and Adolescent Patient Experience with Cyclic Vomiting
Syndrome: A Concept Elicitation Study
Version: 3 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Which was the time distance between episode of CVS and completion of the
questionnaire ? Authors should reported mean duration of each phase Did adolescence receive
any antiemetics? Conditions could be preferably used for anxiety, missing school and suffering
Methods Cannabis would be better to be excluded at all  Vomiting related to drugs should be
excluded when there is a time proximity to emetogenic medication Other causes of vomiting
Objective criteria should be reported in sample size calculation Patient demographics and
clinical characteristics should be described Were all patients consecutive? What happened
with non-English speaking subjects? In what way stressful events and anxiety/depression were
measured? Did authors use a particular scale? Impact in life would be better measured using
a quality of life scale Statistical methods should be described as well as size of the study
calculation Results Because only one adolescent was evaluated back to back it would be
preferable to be excluded Could smoking and alcohol consumption habit data be provided? Did
patients report hyperosmia ( increased irritability in smells) before the episodes?Have authors
divided day to define a part when particularly events happened or do they suggest that episodes
happened around the same time-point each time Do they imply that light might have some
correlation? Perhaps because the size of the document is quite large this part could be omitted
Possibly anxiety and depression should be better categorized as precipitating factors rather than
prodromal symptoms Does lightheadedness mean hyperpnea?
Title: Understanding the Adult and Adolescent Patient Experience with Cyclic Vomiting
Syndrome: A Concept Elicitation Study
Version: 3 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Which was the time distance between episode of CVS and completion of the
questionnaire ? Authors should reported mean duration of each phase Did adolescence receive
any antiemetics? Conditions could be preferably used for anxiety, missing school and suffering
Methods Cannabis would be better to be excluded at all  Vomiting related to drugs should be
excluded when there is a time proximity to emetogenic medication Other causes of vomiting
Objective criteria should be reported in sample size calculation Patient demographics and
clinical characteristics should be described Were all patients consecutive? What happened
with non-English speaking subjects? In what way stressful events and anxiety/depression were
measured? Did authors use a particular scale? Impact in life would be better measured using
a quality of life scale Statistical methods should be described as well as size of the study
calculation Results Because only one adolescent was evaluated back to back it would be
preferable to be excluded Could smoking and alcohol consumption habit data be provided? Did
patients report hyperosmia ( increased irritability in smells) before the episodes?Have authors
divided day to define a part when particularly events happened or do they suggest that episodes
happened around the same time-point each time Do they imply that light might have some
correlation? Perhaps because the size of the document is quite large this part could be omitted
Possibly anxiety and depression should be better categorized as precipitating factors rather than
prodromal symptoms Does lightheadedness mean hyperpnea?
Please review this paper.
user
Title: Understanding the Adult and Adolescent Patient Experience with Cyclic Vomiting
Syndrome: A Concept Elicitation Study
Version: 3 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Which was the time distance between episode of CVS and completion of the
questionnaire ? Authors should reported mean duration of each phase Did adolescence receive
any antiemetics? Conditions could be preferably used for anxiety, missing school and suffering
Methods Cannabis would be better to be excluded at all  Vomiting related to drugs should be
excluded when there is a time proximity to emetogenic medication Other causes of vomiting
Objective criteria should be reported in sample size calculation Patient demographics and
clinical characteristics should be described Were all patients consecutive? What happened
with non-English speaking subjects? In what way stressful events and anxiety/depression were
measured? Did authors use a particular scale? Impact in life would be better measured using
a quality of life scale Statistical methods should be described as well as size of the study
calculation Results Because only one adolescent was evaluated back to back it would be
preferable to be excluded Could smoking and alcohol consumption habit data be provided? Did
patients report hyperosmia ( increased irritability in smells) before the episodes?Have authors
divided day to define a part when particularly events happened or do they suggest that episodes
happened around the same time-point each time Do they imply that light might have some
correlation? Perhaps because the size of the document is quite large this part could be omitted
Possibly anxiety and depression should be better categorized as precipitating factors rather than
prodromal symptoms Does lightheadedness mean hyperpnea?
assistant