Reviewer's report
Title:Radioactive I-131 induced hepatotoxicity
Version:4Date:1 February 2015
Reviewer: Thomas Ritz
Reviewer's report:
Major Compulsory Revisions:
1. Reference should be made to “Iodine-131 induced hepatotoxicity in previously
healthy patients with Grave’s disease” published in “Thyroid Research” in 2013.
In this case report the authors also indicate on acute hepatotoxicity after
treatment with radioactive iodine.
2. Revision to case presentation, 3rd paragraph: With a RUCAM score of 7
induced liver injury by I-131 administration is more “probable” then “definite”.
3. Revision to case presentation section, 3rd paragraph: The authors mention the
increase of total bilirubin. Additionally, the progression of the AST and ALT levels
should be mentioned as markers of hepatic injury as well.
Minor Essential Revisions:
1. Case presentation, 2nd paragraph: It is recommended to be more specific
about the blood markers the authors are referring to and provide references (viral
hepatitis antibodies or PCR examination, which autoimmune serologies).
2. A more differentiated reflection between the chronic diffuse hepatopathy
observed in abdominal ultrasound and the normal MRI examination results
should have been considered by the authors.
Minor issues not for publication:
1. Revision to case presentation, 2nd paragraph: Thicken gallbladder instead of
thickengallbladder.
2. Revision to case presentation, 3rd paragraph:The reference [8] should be
revoked.
3. Conclusion 5th paragraph: “The patient presents typical cholestatic damage”
instead of “The patient present typical cholestatic damage” and “when patients
present liver injury” instead of “when patient present liver injury”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Radioactive I-131 induced hepatotoxicity
Version:4Date:1 February 2015
Reviewer: Thomas Ritz
Reviewer's report:
Major Compulsory Revisions:
1. Reference should be made to “Iodine-131 induced hepatotoxicity in previously
healthy patients with Grave’s disease” published in “Thyroid Research” in 2013.
In this case report the authors also indicate on acute hepatotoxicity after
treatment with radioactive iodine.
2. Revision to case presentation, 3rd paragraph: With a RUCAM score of 7
induced liver injury by I-131 administration is more “probable” then “definite”.
3. Revision to case presentation section, 3rd paragraph: The authors mention the
increase of total bilirubin. Additionally, the progression of the AST and ALT levels
should be mentioned as markers of hepatic injury as well.
Minor Essential Revisions:
1. Case presentation, 2nd paragraph: It is recommended to be more specific
about the blood markers the authors are referring to and provide references (viral
hepatitis antibodies or PCR examination, which autoimmune serologies).
2. A more differentiated reflection between the chronic diffuse hepatopathy
observed in abdominal ultrasound and the normal MRI examination results
should have been considered by the authors.
Minor issues not for publication:
1. Revision to case presentation, 2nd paragraph: Thicken gallbladder instead of
thickengallbladder.
2. Revision to case presentation, 3rd paragraph:The reference [8] should be
revoked.
3. Conclusion 5th paragraph: “The patient presents typical cholestatic damage”
instead of “The patient present typical cholestatic damage” and “when patients
present liver injury” instead of “when patient present liver injury”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Radioactive I-131 induced hepatotoxicity
Version:4Date:1 February 2015
Reviewer: Thomas Ritz
Reviewer's report:
Major Compulsory Revisions:
1. Reference should be made to “Iodine-131 induced hepatotoxicity in previously
healthy patients with Grave’s disease” published in “Thyroid Research” in 2013.
In this case report the authors also indicate on acute hepatotoxicity after
treatment with radioactive iodine.
2. Revision to case presentation, 3rd paragraph: With a RUCAM score of 7
induced liver injury by I-131 administration is more “probable” then “definite”.
3. Revision to case presentation section, 3rd paragraph: The authors mention the
increase of total bilirubin. Additionally, the progression of the AST and ALT levels
should be mentioned as markers of hepatic injury as well.
Minor Essential Revisions:
1. Case presentation, 2nd paragraph: It is recommended to be more specific
about the blood markers the authors are referring to and provide references (viral
hepatitis antibodies or PCR examination, which autoimmune serologies).
2. A more differentiated reflection between the chronic diffuse hepatopathy
observed in abdominal ultrasound and the normal MRI examination results
should have been considered by the authors.
Minor issues not for publication:
1. Revision to case presentation, 2nd paragraph: Thicken gallbladder instead of
thickengallbladder.
2. Revision to case presentation, 3rd paragraph:The reference [8] should be
revoked.
3. Conclusion 5th paragraph: “The patient presents typical cholestatic damage”
instead of “The patient present typical cholestatic damage” and “when patients
present liver injury” instead of “when patient present liver injury”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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