Reviewer's report
Title:Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients
with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs
Version: 1Date:7 November 2012
Reviewer: Akinori Yanaka
Reviewer's report:
Discretionary Revisions
1.Since the efficacy of PPI is influenced by genotype of CYP2C19, it seems also
important to show the data on the adverse events of esomeprazole among three
different genotypes of CYP2C19.
2.There are 5 cases of ulcer relapse, despite the treatment of esomeprazole for 1
year period. It seems useful to show clinical characteristic of the 5 cases by
Table, in order to give us information about what kinds of risk factors are related
to NSAIDs-related ulcer relapse among patients taking with esomeprazole.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients
with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs
Version: 1Date:7 November 2012
Reviewer: Akinori Yanaka
Reviewer's report:
Discretionary Revisions
1.Since the efficacy of PPI is influenced by genotype of CYP2C19, it seems also
important to show the data on the adverse events of esomeprazole among three
different genotypes of CYP2C19.
2.There are 5 cases of ulcer relapse, despite the treatment of esomeprazole for 1
year period. It seems useful to show clinical characteristic of the 5 cases by
Table, in order to give us information about what kinds of risk factors are related
to NSAIDs-related ulcer relapse among patients taking with esomeprazole.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
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Reviewer's report
Title:Safety and efficacy of long-term esomeprazole 20 mg in Japanese patients
with a history of peptic ulcer receiving daily non-steroidal anti-inflammatory drugs
Version: 1Date:7 November 2012
Reviewer: Akinori Yanaka
Reviewer's report:
Discretionary Revisions
1.Since the efficacy of PPI is influenced by genotype of CYP2C19, it seems also
important to show the data on the adverse events of esomeprazole among three
different genotypes of CYP2C19.
2.There are 5 cases of ulcer relapse, despite the treatment of esomeprazole for 1
year period. It seems useful to show clinical characteristic of the 5 cases by
Table, in order to give us information about what kinds of risk factors are related
to NSAIDs-related ulcer relapse among patients taking with esomeprazole.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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