Title: T2-weighted imaging and dynamic contrast#enhanced imaging in predicting the
prognosis in patients with acute-on-chronic liver failure
Version: 1 Date: 08 Jul 2023
Reviewer:  Alireza Aziz-Ahari
Reviewer's report:
Overall, the manuscript provides valuable insights into the use of MRI imaging features to
predict the prognosis of patients with ACLF. Study design, methodology, and research seem
appropriate. However, there are some potential issues that can be addressed:
Language & Writing Style:
The manuscript should be proofread and edited for grammatical errors, typos and syntax.
The style can be improved to make it clearer.
Study design and procedure:
It is not clear if the Gd-enhanced hepatic MRI was performed for all of acute-on-chronic liver
failure patients in the study period? If not, what were the indications for performed MRIs? Was
the renal function a consideration?
The manuscript briefly states that two radiologists reviewed and commented on the MR images.
However, it would be useful to provide more information on inter-rater agreement or possible
disagreements and how they were resolved.
Discussion and Conclusion:
The discussion section summarizes the findings and implications accordingly. However, it can
be expanded to include detailed comparisons with previous studies regarding any discrepancies
or similarities in the results.
The concluding section provides a brief overview but could be strengthened by emphasizing
clinical implications and possible future research directions.
Overall, the manuscript provides valuable insight into the use of MRI imaging features as
prognostic factors in ACLF. Addressing the above issues will improve the clarity and power
of the manuscript.
Title: T2-weighted imaging and dynamic contrast#enhanced imaging in predicting the
prognosis in patients with acute-on-chronic liver failure
Version: 1 Date: 08 Jul 2023
Reviewer:  Alireza Aziz-Ahari
Reviewer's report:
Overall, the manuscript provides valuable insights into the use of MRI imaging features to
predict the prognosis of patients with ACLF. Study design, methodology, and research seem
appropriate. However, there are some potential issues that can be addressed:
Language & Writing Style:
The manuscript should be proofread and edited for grammatical errors, typos and syntax.
The style can be improved to make it clearer.
Study design and procedure:
It is not clear if the Gd-enhanced hepatic MRI was performed for all of acute-on-chronic liver
failure patients in the study period? If not, what were the indications for performed MRIs? Was
the renal function a consideration?
The manuscript briefly states that two radiologists reviewed and commented on the MR images.
However, it would be useful to provide more information on inter-rater agreement or possible
disagreements and how they were resolved.
Discussion and Conclusion:
The discussion section summarizes the findings and implications accordingly. However, it can
be expanded to include detailed comparisons with previous studies regarding any discrepancies
or similarities in the results.
The concluding section provides a brief overview but could be strengthened by emphasizing
clinical implications and possible future research directions.
Overall, the manuscript provides valuable insight into the use of MRI imaging features as
prognostic factors in ACLF. Addressing the above issues will improve the clarity and power
of the manuscript.
Please review this paper.
user
Title: T2-weighted imaging and dynamic contrast#enhanced imaging in predicting the
prognosis in patients with acute-on-chronic liver failure
Version: 1 Date: 08 Jul 2023
Reviewer:  Alireza Aziz-Ahari
Reviewer's report:
Overall, the manuscript provides valuable insights into the use of MRI imaging features to
predict the prognosis of patients with ACLF. Study design, methodology, and research seem
appropriate. However, there are some potential issues that can be addressed:
Language & Writing Style:
The manuscript should be proofread and edited for grammatical errors, typos and syntax.
The style can be improved to make it clearer.
Study design and procedure:
It is not clear if the Gd-enhanced hepatic MRI was performed for all of acute-on-chronic liver
failure patients in the study period? If not, what were the indications for performed MRIs? Was
the renal function a consideration?
The manuscript briefly states that two radiologists reviewed and commented on the MR images.
However, it would be useful to provide more information on inter-rater agreement or possible
disagreements and how they were resolved.
Discussion and Conclusion:
The discussion section summarizes the findings and implications accordingly. However, it can
be expanded to include detailed comparisons with previous studies regarding any discrepancies
or similarities in the results.
The concluding section provides a brief overview but could be strengthened by emphasizing
clinical implications and possible future research directions.
Overall, the manuscript provides valuable insight into the use of MRI imaging features as
prognostic factors in ACLF. Addressing the above issues will improve the clarity and power
of the manuscript.
assistant