Title: Evaluation of vital genes correlated with CD8+ T cell infiltration as prognostic biomarkers
in stomach adenocarcinoma
Version: 2 Date: 04 Jul 2023
Reviewer:  Anjali Dhall
Reviewer's report:
Comment 1: Introduction need revision. Add latest cancer statistics information in the
introduction section of manuscript.
Comment 2: Please revise the sentences of line number 48; for instance “advanced patients”.
Comment 3: In the literature various deconvolution methods are available such as : xCell,
TIMER, EPIC, quantiseq etc. Please explain the other methods also in introduction or discussion
section and provide the reason of implementing CIBERSORT in the manuscript.
Comment 4: Please specify the “Common gene expression data” Line number 82.
Comment 5: Please explain “paracancerous” tissue samples.
Comment 6: ADD spaces after in line 241.
Comment 7: Please explain T,M,N, and G stages in the manuscript.
Comment 8: References are missing for TIMER, XCELL and EPIC algorithm.
Comment 9: Incorporate the other STAD associated gene signatures reported in the previous
studies.
Comment 10: Discrepancy in the Figure 1 legend and text mentioned in the result section of
manuscript, please clarify it.
Comment 11: The authors should improve the overall language of the manuscript as per the
journal standards.
Title: Evaluation of vital genes correlated with CD8+ T cell infiltration as prognostic biomarkers
in stomach adenocarcinoma
Version: 2 Date: 04 Jul 2023
Reviewer:  Anjali Dhall
Reviewer's report:
Comment 1: Introduction need revision. Add latest cancer statistics information in the
introduction section of manuscript.
Comment 2: Please revise the sentences of line number 48; for instance “advanced patients”.
Comment 3: In the literature various deconvolution methods are available such as : xCell,
TIMER, EPIC, quantiseq etc. Please explain the other methods also in introduction or discussion
section and provide the reason of implementing CIBERSORT in the manuscript.
Comment 4: Please specify the “Common gene expression data” Line number 82.
Comment 5: Please explain “paracancerous” tissue samples.
Comment 6: ADD spaces after in line 241.
Comment 7: Please explain T,M,N, and G stages in the manuscript.
Comment 8: References are missing for TIMER, XCELL and EPIC algorithm.
Comment 9: Incorporate the other STAD associated gene signatures reported in the previous
studies.
Comment 10: Discrepancy in the Figure 1 legend and text mentioned in the result section of
manuscript, please clarify it.
Comment 11: The authors should improve the overall language of the manuscript as per the
journal standards.
Please review this paper.
user
Title: Evaluation of vital genes correlated with CD8+ T cell infiltration as prognostic biomarkers
in stomach adenocarcinoma
Version: 2 Date: 04 Jul 2023
Reviewer:  Anjali Dhall
Reviewer's report:
Comment 1: Introduction need revision. Add latest cancer statistics information in the
introduction section of manuscript.
Comment 2: Please revise the sentences of line number 48; for instance “advanced patients”.
Comment 3: In the literature various deconvolution methods are available such as : xCell,
TIMER, EPIC, quantiseq etc. Please explain the other methods also in introduction or discussion
section and provide the reason of implementing CIBERSORT in the manuscript.
Comment 4: Please specify the “Common gene expression data” Line number 82.
Comment 5: Please explain “paracancerous” tissue samples.
Comment 6: ADD spaces after in line 241.
Comment 7: Please explain T,M,N, and G stages in the manuscript.
Comment 8: References are missing for TIMER, XCELL and EPIC algorithm.
Comment 9: Incorporate the other STAD associated gene signatures reported in the previous
studies.
Comment 10: Discrepancy in the Figure 1 legend and text mentioned in the result section of
manuscript, please clarify it.
Comment 11: The authors should improve the overall language of the manuscript as per the
journal standards.
assistant