Title:  Efficacy of Prophylactic Dexamethasone in Reducing Post-Embolization Syndrome
Following Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A
Systematic Review and Meta-Analysis
Version: 0 Date: 01 Jul 2024
Reviewer:  Haohuan Tang
Reviewer's report:
PES is the most common adverse reaction after TACE, and the authors, through a systematic
review and meta-analysis of RCT studies, described the perioperative prophylactic use of
dexamethasone, which relieves abdominal pain, fever, nausea, and vomiting This is a practical
guide for clinical work, but there are some limitations.
1, prophylactic use of dexamethasone, which relieves the incidence of symptoms such as
abdominal pain, fever, nausea, and vomiting, but the study does not seem to mention the grade
of adverse effects; did the use of dexamethasone improve the grading of AEs?
2, The authors compared the effects of embolization materials, dexamethasone dose, and
observation time on the results of the studies in subgroup analyses. In addition to this, conditions
such as the degree of embolization and tumor load were, in some studies, influential factors in the
occurrence of PES. In addition, in several of the RCT studies analyzed in the article, there were
differences in the type of chemotherapy drugs used. What do the authors make of these issues?
3, The studies included in the article focused on conventional TACE and reported less on the
safety of dexamethasone, which the authors could not quantify. Therefore the generalization of
study findings needs to be done with caution.
4, The language needs to be further trimmed and embellished.
Title:  Efficacy of Prophylactic Dexamethasone in Reducing Post-Embolization Syndrome
Following Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A
Systematic Review and Meta-Analysis
Version: 0 Date: 01 Jul 2024
Reviewer:  Haohuan Tang
Reviewer's report:
PES is the most common adverse reaction after TACE, and the authors, through a systematic
review and meta-analysis of RCT studies, described the perioperative prophylactic use of
dexamethasone, which relieves abdominal pain, fever, nausea, and vomiting This is a practical
guide for clinical work, but there are some limitations.
1, prophylactic use of dexamethasone, which relieves the incidence of symptoms such as
abdominal pain, fever, nausea, and vomiting, but the study does not seem to mention the grade
of adverse effects; did the use of dexamethasone improve the grading of AEs?
2, The authors compared the effects of embolization materials, dexamethasone dose, and
observation time on the results of the studies in subgroup analyses. In addition to this, conditions
such as the degree of embolization and tumor load were, in some studies, influential factors in the
occurrence of PES. In addition, in several of the RCT studies analyzed in the article, there were
differences in the type of chemotherapy drugs used. What do the authors make of these issues?
3, The studies included in the article focused on conventional TACE and reported less on the
safety of dexamethasone, which the authors could not quantify. Therefore the generalization of
study findings needs to be done with caution.
4, The language needs to be further trimmed and embellished.
Please review this paper.
user
Title:  Efficacy of Prophylactic Dexamethasone in Reducing Post-Embolization Syndrome
Following Transcatheter Arterial Chemoembolization for Hepatocellular Carcinoma: A
Systematic Review and Meta-Analysis
Version: 0 Date: 01 Jul 2024
Reviewer:  Haohuan Tang
Reviewer's report:
PES is the most common adverse reaction after TACE, and the authors, through a systematic
review and meta-analysis of RCT studies, described the perioperative prophylactic use of
dexamethasone, which relieves abdominal pain, fever, nausea, and vomiting This is a practical
guide for clinical work, but there are some limitations.
1, prophylactic use of dexamethasone, which relieves the incidence of symptoms such as
abdominal pain, fever, nausea, and vomiting, but the study does not seem to mention the grade
of adverse effects; did the use of dexamethasone improve the grading of AEs?
2, The authors compared the effects of embolization materials, dexamethasone dose, and
observation time on the results of the studies in subgroup analyses. In addition to this, conditions
such as the degree of embolization and tumor load were, in some studies, influential factors in the
occurrence of PES. In addition, in several of the RCT studies analyzed in the article, there were
differences in the type of chemotherapy drugs used. What do the authors make of these issues?
3, The studies included in the article focused on conventional TACE and reported less on the
safety of dexamethasone, which the authors could not quantify. Therefore the generalization of
study findings needs to be done with caution.
4, The language needs to be further trimmed and embellished.
assistant