Title: The effects of chemotherapy, primary tumor location and histological subtype on the
survival of stage III colon cancer patients
Version: 0 Date: 15 Aug 2022
Reviewer's report:
The authors examined a large number of patients with colorectal cancer and found that the right-
sided colon cancer, mucinous adenocarcinoma, and the presence of chemotherapy are important
survival factors. Although these results have some useful information for clinicians, novelty was
slight.
1. As the home page of ESMO, it is well-known that mucinous colorectal cancer is associated
with poorer survival and has a character with chemo-resistance. Mucinous Colorectal Cancer
| ESMO
2.  The authors should exclude the chemotherapy unknown patients.
3.  It is not clear that chemotherapy means either postoperative adjuvant therapy or systemic
therapy after disease-recurrence.
4.  Recently, it was revealed that high-frequency MSI (MSI-H) status reduced survival in
patients receiving 5-FU-based adjuvant chemotherapy. Therefore, various guidelines indicated
that MSI-status should be examined before adjuvant therapy.  So, the authors should show which
chemotherapy has been done in these patients.
Title: The effects of chemotherapy, primary tumor location and histological subtype on the
survival of stage III colon cancer patients
Version: 0 Date: 15 Aug 2022
Reviewer's report:
The authors examined a large number of patients with colorectal cancer and found that the right-
sided colon cancer, mucinous adenocarcinoma, and the presence of chemotherapy are important
survival factors. Although these results have some useful information for clinicians, novelty was
slight.
1. As the home page of ESMO, it is well-known that mucinous colorectal cancer is associated
with poorer survival and has a character with chemo-resistance. Mucinous Colorectal Cancer
| ESMO
2.  The authors should exclude the chemotherapy unknown patients.
3.  It is not clear that chemotherapy means either postoperative adjuvant therapy or systemic
therapy after disease-recurrence.
4.  Recently, it was revealed that high-frequency MSI (MSI-H) status reduced survival in
patients receiving 5-FU-based adjuvant chemotherapy. Therefore, various guidelines indicated
that MSI-status should be examined before adjuvant therapy.  So, the authors should show which
chemotherapy has been done in these patients.
Please review this paper.
user
Title: The effects of chemotherapy, primary tumor location and histological subtype on the
survival of stage III colon cancer patients
Version: 0 Date: 15 Aug 2022
Reviewer's report:
The authors examined a large number of patients with colorectal cancer and found that the right-
sided colon cancer, mucinous adenocarcinoma, and the presence of chemotherapy are important
survival factors. Although these results have some useful information for clinicians, novelty was
slight.
1. As the home page of ESMO, it is well-known that mucinous colorectal cancer is associated
with poorer survival and has a character with chemo-resistance. Mucinous Colorectal Cancer
| ESMO
2.  The authors should exclude the chemotherapy unknown patients.
3.  It is not clear that chemotherapy means either postoperative adjuvant therapy or systemic
therapy after disease-recurrence.
4.  Recently, it was revealed that high-frequency MSI (MSI-H) status reduced survival in
patients receiving 5-FU-based adjuvant chemotherapy. Therefore, various guidelines indicated
that MSI-status should be examined before adjuvant therapy.  So, the authors should show which
chemotherapy has been done in these patients.
assistant