Title: The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis
Version: 1 Date: 04 Jul 2024
Reviewer's report:
In the present systematic review with meta-analysis, Authors found that at diagnosis only a minor
percentage of celiac disease (CD) patients were underweight, while high BMI was associated
with CD diagnostic delay. Main comments:
1) A linguistic revision is necessary.
2) Literature search was updated to almost 2 years ago (October 2022).
3) I do not understand why, if > 800000 healthy controls were found, Authors analyzed only raw
percentages (with which method? inverse variance? This was not stated) in celiac patients instead
of making a comparison with controls. This would have given more interesting results whether
prevalence of obesity/underweight were more or less common in CD. Of note, an analysis of
this type was reported in figure 7, but no details about the type of meta-analysis was reported
in the Methods section.
4) The last three lines in Discussion paragraph of the Abstract seem to give a contradictory
message regarding the link between age and BMI.
Title: The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis
Version: 1 Date: 04 Jul 2024
Reviewer's report:
In the present systematic review with meta-analysis, Authors found that at diagnosis only a minor
percentage of celiac disease (CD) patients were underweight, while high BMI was associated
with CD diagnostic delay. Main comments:
1) A linguistic revision is necessary.
2) Literature search was updated to almost 2 years ago (October 2022).
3) I do not understand why, if > 800000 healthy controls were found, Authors analyzed only raw
percentages (with which method? inverse variance? This was not stated) in celiac patients instead
of making a comparison with controls. This would have given more interesting results whether
prevalence of obesity/underweight were more or less common in CD. Of note, an analysis of
this type was reported in figure 7, but no details about the type of meta-analysis was reported
in the Methods section.
4) The last three lines in Discussion paragraph of the Abstract seem to give a contradictory
message regarding the link between age and BMI.
Please review this paper.
user
Title: The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis
Version: 1 Date: 04 Jul 2024
Reviewer's report:
In the present systematic review with meta-analysis, Authors found that at diagnosis only a minor
percentage of celiac disease (CD) patients were underweight, while high BMI was associated
with CD diagnostic delay. Main comments:
1) A linguistic revision is necessary.
2) Literature search was updated to almost 2 years ago (October 2022).
3) I do not understand why, if > 800000 healthy controls were found, Authors analyzed only raw
percentages (with which method? inverse variance? This was not stated) in celiac patients instead
of making a comparison with controls. This would have given more interesting results whether
prevalence of obesity/underweight were more or less common in CD. Of note, an analysis of
this type was reported in figure 7, but no details about the type of meta-analysis was reported
in the Methods section.
4) The last three lines in Discussion paragraph of the Abstract seem to give a contradictory
message regarding the link between age and BMI.
assistant