Title: The causal relationship between inflammatory bowel diseases and erythema nodosum: a
bidirectional two-sample Mendelian randomization study
Version: 1 Date: 02 Apr 2024
Reviewer:  Menglong Zou
Reviewer's report:
In this manuscript, the authors attempt to investigate the relationship between IBD and EN using
Mendelian randomization. IBD may present with several kinds of extraintestinal manifestations
that impact multiple systems, primarily the musculoskeletal, skin, and eyes. This study is a great
idea, but I have the following concerns:
1. The authors did not meta-analyze the data, so why did they mention the meta-package in the
methods section?
2. Multiple corrections are required to eliminate false discovery rates.
3. The authors used the PhenoScannerV2 database to remove confounding SNPs, but in the
results section the authors failed to do so. This is not rigorous.
Title: The causal relationship between inflammatory bowel diseases and erythema nodosum: a
bidirectional two-sample Mendelian randomization study
Version: 1 Date: 02 Apr 2024
Reviewer:  Menglong Zou
Reviewer's report:
In this manuscript, the authors attempt to investigate the relationship between IBD and EN using
Mendelian randomization. IBD may present with several kinds of extraintestinal manifestations
that impact multiple systems, primarily the musculoskeletal, skin, and eyes. This study is a great
idea, but I have the following concerns:
1. The authors did not meta-analyze the data, so why did they mention the meta-package in the
methods section?
2. Multiple corrections are required to eliminate false discovery rates.
3. The authors used the PhenoScannerV2 database to remove confounding SNPs, but in the
results section the authors failed to do so. This is not rigorous.
Please review this paper.
user
Title: The causal relationship between inflammatory bowel diseases and erythema nodosum: a
bidirectional two-sample Mendelian randomization study
Version: 1 Date: 02 Apr 2024
Reviewer:  Menglong Zou
Reviewer's report:
In this manuscript, the authors attempt to investigate the relationship between IBD and EN using
Mendelian randomization. IBD may present with several kinds of extraintestinal manifestations
that impact multiple systems, primarily the musculoskeletal, skin, and eyes. This study is a great
idea, but I have the following concerns:
1. The authors did not meta-analyze the data, so why did they mention the meta-package in the
methods section?
2. Multiple corrections are required to eliminate false discovery rates.
3. The authors used the PhenoScannerV2 database to remove confounding SNPs, but in the
results section the authors failed to do so. This is not rigorous.
assistant