Reviewer's report
Title:Serological parameters in the spectrum of coeliac disease: beyond
standard antibody testing - a cohort study
Version: 1Date:2 July 2012
Reviewer: Severin Daum
Reviewer's report:
Serological parameters in the spectrum of coeliac disease: beyond standard
antibody testing - a cohort study
Major Remarks
The authors present interesting retrospective data on serological markers for
differentiation of several types of CD. These data are highly interesting and
clinically relevant as often invasive methods have to be applicated with limited
success in the differentiation of RCD I versus RCD II and EATL.
Some more intense discussion of the data could bring more value to the readers
of BMC.
Minor Remarks
The results data should be described more careful: in case both types of RCD
are meant, this should be mentioned. Actually, results data are described in the
DISCUSSION section, which should be placed in the RESULTS section. Data
should be interpreted in the DISCUSSION, not repeated.
The authors should speculate about using several combined markers in
differentiation of CD vs. RCD and EATL.
Table 2 showing the detailed parameters of all CD groups could be substituted
(or put in the ammendment), if the p-values in case of significance would be
depicted in figure 1 and 2 (eg showing a bar between box plots with significant
differences).
Some grammatical mistakes should be corrected, eg crypt _ hyperplasia on page
5 line 13.
Abbreviation of active celiac disease (aCD) should be introduced in the text.
As I am not a statistician, I would beg you to get the article checked by a
statistician.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests'
Reviewer's report
Title:Serological parameters in the spectrum of coeliac disease: beyond
standard antibody testing - a cohort study
Version: 1Date:2 July 2012
Reviewer: Severin Daum
Reviewer's report:
Serological parameters in the spectrum of coeliac disease: beyond standard
antibody testing - a cohort study
Major Remarks
The authors present interesting retrospective data on serological markers for
differentiation of several types of CD. These data are highly interesting and
clinically relevant as often invasive methods have to be applicated with limited
success in the differentiation of RCD I versus RCD II and EATL.
Some more intense discussion of the data could bring more value to the readers
of BMC.
Minor Remarks
The results data should be described more careful: in case both types of RCD
are meant, this should be mentioned. Actually, results data are described in the
DISCUSSION section, which should be placed in the RESULTS section. Data
should be interpreted in the DISCUSSION, not repeated.
The authors should speculate about using several combined markers in
differentiation of CD vs. RCD and EATL.
Table 2 showing the detailed parameters of all CD groups could be substituted
(or put in the ammendment), if the p-values in case of significance would be
depicted in figure 1 and 2 (eg showing a bar between box plots with significant
differences).
Some grammatical mistakes should be corrected, eg crypt _ hyperplasia on page
5 line 13.
Abbreviation of active celiac disease (aCD) should be introduced in the text.
As I am not a statistician, I would beg you to get the article checked by a
statistician.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Serological parameters in the spectrum of coeliac disease: beyond
standard antibody testing - a cohort study
Version: 1Date:2 July 2012
Reviewer: Severin Daum
Reviewer's report:
Serological parameters in the spectrum of coeliac disease: beyond standard
antibody testing - a cohort study
Major Remarks
The authors present interesting retrospective data on serological markers for
differentiation of several types of CD. These data are highly interesting and
clinically relevant as often invasive methods have to be applicated with limited
success in the differentiation of RCD I versus RCD II and EATL.
Some more intense discussion of the data could bring more value to the readers
of BMC.
Minor Remarks
The results data should be described more careful: in case both types of RCD
are meant, this should be mentioned. Actually, results data are described in the
DISCUSSION section, which should be placed in the RESULTS section. Data
should be interpreted in the DISCUSSION, not repeated.
The authors should speculate about using several combined markers in
differentiation of CD vs. RCD and EATL.
Table 2 showing the detailed parameters of all CD groups could be substituted
(or put in the ammendment), if the p-values in case of significance would be
depicted in figure 1 and 2 (eg showing a bar between box plots with significant
differences).
Some grammatical mistakes should be corrected, eg crypt _ hyperplasia on page
5 line 13.
Abbreviation of active celiac disease (aCD) should be introduced in the text.
As I am not a statistician, I would beg you to get the article checked by a
statistician.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests'
assistant