Reviewer's report
Title:Mutational Profiles of Different Macroscopic Subtypes of Colorectal
Adenoma Reveal Distinct Pathogenetic Roles for KRAS, BRAF and PIK3CA
Version:3Date:10 November 2014
Reviewer: Yutaka Saito
Reviewer's report:
I read this paper with interest. This is an important paper, however, there is minor
points to be revised.
Please describe the reason why k-ras and b-raf mutation were 0% in 24
depressed type cancers in detailed. It is a little bit strange.
Please refer to the paper.
Distinct molecular features of different macroscopic subtypes of colorectal
neoplasms.
Konda K, Konishi K, Yamochi T, Ito YM, Nozawa H, Tojo M, Shinmura K, Kogo
M, Katagiri A, Kubota Y, Muramoto T, Yano Y, Kobayashi Y, Kihara T, Tagawa T,
Makino R, Takimoto M, Imawari M, Yoshida H.
PLoS One. 2014 Aug 5;9(8):e103822
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests' below
Reviewer's report
Title:Mutational Profiles of Different Macroscopic Subtypes of Colorectal
Adenoma Reveal Distinct Pathogenetic Roles for KRAS, BRAF and PIK3CA
Version:3Date:10 November 2014
Reviewer: Yutaka Saito
Reviewer's report:
I read this paper with interest. This is an important paper, however, there is minor
points to be revised.
Please describe the reason why k-ras and b-raf mutation were 0% in 24
depressed type cancers in detailed. It is a little bit strange.
Please refer to the paper.
Distinct molecular features of different macroscopic subtypes of colorectal
neoplasms.
Konda K, Konishi K, Yamochi T, Ito YM, Nozawa H, Tojo M, Shinmura K, Kogo
M, Katagiri A, Kubota Y, Muramoto T, Yano Y, Kobayashi Y, Kihara T, Tagawa T,
Makino R, Takimoto M, Imawari M, Yoshida H.
PLoS One. 2014 Aug 5;9(8):e103822
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests' below
Please review this paper.
user
Reviewer's report
Title:Mutational Profiles of Different Macroscopic Subtypes of Colorectal
Adenoma Reveal Distinct Pathogenetic Roles for KRAS, BRAF and PIK3CA
Version:3Date:10 November 2014
Reviewer: Yutaka Saito
Reviewer's report:
I read this paper with interest. This is an important paper, however, there is minor
points to be revised.
Please describe the reason why k-ras and b-raf mutation were 0% in 24
depressed type cancers in detailed. It is a little bit strange.
Please refer to the paper.
Distinct molecular features of different macroscopic subtypes of colorectal
neoplasms.
Konda K, Konishi K, Yamochi T, Ito YM, Nozawa H, Tojo M, Shinmura K, Kogo
M, Katagiri A, Kubota Y, Muramoto T, Yano Y, Kobayashi Y, Kihara T, Tagawa T,
Makino R, Takimoto M, Imawari M, Yoshida H.
PLoS One. 2014 Aug 5;9(8):e103822
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests' below
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