Title: MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells
Version: 0 Date: 27 Sep 2021
Reviewer's report:
1) In the introduction section, the authors should describe the CENPF role in cancer development
in more detail. In addition, the role of miR-1 was described earlier by other groups, I dont see
it introduced in this part nor discussed in the discussion section. What is the true novelty of
the present study? Furthermore, it is not clear how the authors selected CENPF-miR-1 axis
for further analysis, as the statistical analysis which was performed as described in the method
section 1.1 would lead to dozen potential miRNA-gene interactions. Please describe in more
detail.
2) What is the difference between basic characteristics of cell lines selected in the present study,
and why the authors selected only one cell line for further biological analyses? The experiments
performed in all selected cell lines would improve greatly the conclusions.
3) What is the novelty of the results presented in section 2.2. Same conclusions were shown
previously (PMID: 25874496).
4) The discussion section should be improved in more detail as described above.
Title: MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells
Version: 0 Date: 27 Sep 2021
Reviewer's report:
1) In the introduction section, the authors should describe the CENPF role in cancer development
in more detail. In addition, the role of miR-1 was described earlier by other groups, I dont see
it introduced in this part nor discussed in the discussion section. What is the true novelty of
the present study? Furthermore, it is not clear how the authors selected CENPF-miR-1 axis
for further analysis, as the statistical analysis which was performed as described in the method
section 1.1 would lead to dozen potential miRNA-gene interactions. Please describe in more
detail.
2) What is the difference between basic characteristics of cell lines selected in the present study,
and why the authors selected only one cell line for further biological analyses? The experiments
performed in all selected cell lines would improve greatly the conclusions.
3) What is the novelty of the results presented in section 2.2. Same conclusions were shown
previously (PMID: 25874496).
4) The discussion section should be improved in more detail as described above.
Please review this paper.
user
Title: MiR-1-3p targets CENPF to repress tumor-relevant functions of gastric cancer cells
Version: 0 Date: 27 Sep 2021
Reviewer's report:
1) In the introduction section, the authors should describe the CENPF role in cancer development
in more detail. In addition, the role of miR-1 was described earlier by other groups, I dont see
it introduced in this part nor discussed in the discussion section. What is the true novelty of
the present study? Furthermore, it is not clear how the authors selected CENPF-miR-1 axis
for further analysis, as the statistical analysis which was performed as described in the method
section 1.1 would lead to dozen potential miRNA-gene interactions. Please describe in more
detail.
2) What is the difference between basic characteristics of cell lines selected in the present study,
and why the authors selected only one cell line for further biological analyses? The experiments
performed in all selected cell lines would improve greatly the conclusions.
3) What is the novelty of the results presented in section 2.2. Same conclusions were shown
previously (PMID: 25874496).
4) The discussion section should be improved in more detail as described above.
assistant