Reviewer's report
Title:Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism
influences the susceptibility to gastric cancer in the Japanese population
Version: 3Date:17 November 2008
Reviewer: Charles Foster
Reviewer's report:
Major Compulsory Revisions:
None
Minor Essential Revisions:
page 8. "Enrolled subjects were undergone upper gastrointestinal endoscopy to
check for gastric cancer followed by a barium X-ray examination as a health
check or for the complaint of abdominal symptoms."
Consider: "Enrolled subjects were screened for gastric cancer by upper
gastrointestinal endoscopy followed by a barium X-ray examination."
page 14. "In previous reports, it was suggested that the decreased
concentrations of selenium was the gastric cancer risk. And in experimental
study, high selenium diet inhibited the H. pylori growth in Guinea pig. Nutrition
effect of selenium, however, has not been defined for prevention of the
development of precancerous lesions of gastric cancer so far."
Consider: "Although low selenium status has been associated with risk of human
gastric cancer, and high selenium diets inhibit the growth of H. pylori in Guinea
pigs, human clinical trials have failed to demonstrate a benefit for selenium
supplements in the prevention of precancerous gastric lesions."
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism
influences the susceptibility to gastric cancer in the Japanese population
Version: 3Date:17 November 2008
Reviewer: Charles Foster
Reviewer's report:
Major Compulsory Revisions:
None
Minor Essential Revisions:
page 8. "Enrolled subjects were undergone upper gastrointestinal endoscopy to
check for gastric cancer followed by a barium X-ray examination as a health
check or for the complaint of abdominal symptoms."
Consider: "Enrolled subjects were screened for gastric cancer by upper
gastrointestinal endoscopy followed by a barium X-ray examination."
page 14. "In previous reports, it was suggested that the decreased
concentrations of selenium was the gastric cancer risk. And in experimental
study, high selenium diet inhibited the H. pylori growth in Guinea pig. Nutrition
effect of selenium, however, has not been defined for prevention of the
development of precancerous lesions of gastric cancer so far."
Consider: "Although low selenium status has been associated with risk of human
gastric cancer, and high selenium diets inhibit the growth of H. pylori in Guinea
pigs, human clinical trials have failed to demonstrate a benefit for selenium
supplements in the prevention of precancerous gastric lesions."
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Selenoprotein S (SEPS1) gene -105G>A promoter polymorphism
influences the susceptibility to gastric cancer in the Japanese population
Version: 3Date:17 November 2008
Reviewer: Charles Foster
Reviewer's report:
Major Compulsory Revisions:
None
Minor Essential Revisions:
page 8. "Enrolled subjects were undergone upper gastrointestinal endoscopy to
check for gastric cancer followed by a barium X-ray examination as a health
check or for the complaint of abdominal symptoms."
Consider: "Enrolled subjects were screened for gastric cancer by upper
gastrointestinal endoscopy followed by a barium X-ray examination."
page 14. "In previous reports, it was suggested that the decreased
concentrations of selenium was the gastric cancer risk. And in experimental
study, high selenium diet inhibited the H. pylori growth in Guinea pig. Nutrition
effect of selenium, however, has not been defined for prevention of the
development of precancerous lesions of gastric cancer so far."
Consider: "Although low selenium status has been associated with risk of human
gastric cancer, and high selenium diets inhibit the growth of H. pylori in Guinea
pigs, human clinical trials have failed to demonstrate a benefit for selenium
supplements in the prevention of precancerous gastric lesions."
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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