Title: 3 L split-dose polyethylene glycol is superior to 2 L polyethylene glycol in colonoscopic
bowel preparation in relatively high-BMI (# 24 kg/m2) individuals:A multicenter randomized
controlled trial
Version: 1 Date: 19 Sep 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
This article has described the feasibility of comparison of different doses of colonoscopy
preparation. This study is a prospective multicenter subgroup analysis of the previous research,
which focused on relatively obese patients in China. It is an exciting study; however, this article
has some concerns. 1. The title “relatively high BMI” is not well understood. Please present
specific values. 2. The authors should present examples of original figures on the cleansing level
of colonoscopy since it relates to the primary outcome. 3. What kind of colonoscopy (e.g., type,
company name) is used in each responsible facility? Did they use NBI or magnifying methods
to detect polyps or just in white light? Are these united in each facility? 4. The withdrawing
time from the cecum of coloscopy influences the ADR. How long did withdraw colonoscopy
from the cecum to the anus approximately? Were they concerned with this study protocol? 5.
They excluded patients with severe cardiac, pulmonary, and renal dysfunction. Please present
specific values in these criteria (e.g., eGFR#30). 6. In the demographics, please preset the ratio
of the degree of liver cirrhosis (e.g., Child classification)
Title: 3 L split-dose polyethylene glycol is superior to 2 L polyethylene glycol in colonoscopic
bowel preparation in relatively high-BMI (# 24 kg/m2) individuals:A multicenter randomized
controlled trial
Version: 1 Date: 19 Sep 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
This article has described the feasibility of comparison of different doses of colonoscopy
preparation. This study is a prospective multicenter subgroup analysis of the previous research,
which focused on relatively obese patients in China. It is an exciting study; however, this article
has some concerns. 1. The title “relatively high BMI” is not well understood. Please present
specific values. 2. The authors should present examples of original figures on the cleansing level
of colonoscopy since it relates to the primary outcome. 3. What kind of colonoscopy (e.g., type,
company name) is used in each responsible facility? Did they use NBI or magnifying methods
to detect polyps or just in white light? Are these united in each facility? 4. The withdrawing
time from the cecum of coloscopy influences the ADR. How long did withdraw colonoscopy
from the cecum to the anus approximately? Were they concerned with this study protocol? 5.
They excluded patients with severe cardiac, pulmonary, and renal dysfunction. Please present
specific values in these criteria (e.g., eGFR#30). 6. In the demographics, please preset the ratio
of the degree of liver cirrhosis (e.g., Child classification)
Please review this paper.
user
Title: 3 L split-dose polyethylene glycol is superior to 2 L polyethylene glycol in colonoscopic
bowel preparation in relatively high-BMI (# 24 kg/m2) individuals:A multicenter randomized
controlled trial
Version: 1 Date: 19 Sep 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
This article has described the feasibility of comparison of different doses of colonoscopy
preparation. This study is a prospective multicenter subgroup analysis of the previous research,
which focused on relatively obese patients in China. It is an exciting study; however, this article
has some concerns. 1. The title “relatively high BMI” is not well understood. Please present
specific values. 2. The authors should present examples of original figures on the cleansing level
of colonoscopy since it relates to the primary outcome. 3. What kind of colonoscopy (e.g., type,
company name) is used in each responsible facility? Did they use NBI or magnifying methods
to detect polyps or just in white light? Are these united in each facility? 4. The withdrawing
time from the cecum of coloscopy influences the ADR. How long did withdraw colonoscopy
from the cecum to the anus approximately? Were they concerned with this study protocol? 5.
They excluded patients with severe cardiac, pulmonary, and renal dysfunction. Please present
specific values in these criteria (e.g., eGFR#30). 6. In the demographics, please preset the ratio
of the degree of liver cirrhosis (e.g., Child classification)
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