Title: Unraveling the role of early coeliac disease diagnosis in the risk of developing immune-
mediated renal diseases
Version: 2 Date: 06 Oct 2024
Reviewer's report:
Reviewer's report:
I thank the authors for their answers. The revised manuscript has been modified quite a a lot,
and it has also improved. I still have some comments concerning the new version:
Whole manuscript:
Please re-check the grammar (for instance on rows 50, 66, 73-77).
Please use certain words in the same way throughout the text (celiac disease, gluten-free diet etc).
Re-check the correct use of abbreviations (for instance on rows 199&208 etc).
Abstract:
In the section of results; when presenting/comparing the different risks, could you mention also
the comparing group (reference individuals)?
How the results of this study may increase the incentive for implementation of large-scale
screening programs for CD?
Introduction:
At least the rows 90-97 should be moved to the section of Methods.
Table 1:
Abbreviations (ICD, IMRD) should be explained.
Results:
I kindly suggest presenting the results of risks using HRs, probably not CIs. For instance, on the
row 153, an increased risk would be over three-fold.
Figure 1:
I recommend changing the word “ALL_IMRD”.
Discussion:
In my opinion, no need to refer to tables in the discussion section.
Do the authors have any explanations for the finding that the risk was increased for nephrotic
syndrome, systemic lupus erythematosus, tubulointerstitial nephritis, and unspecific nephritis
and nephropathy following the CD diagnosis? Please consider having a discussion about it in
the text.
Title: Unraveling the role of early coeliac disease diagnosis in the risk of developing immune-
mediated renal diseases
Version: 2 Date: 06 Oct 2024
Reviewer's report:
Reviewer's report:
I thank the authors for their answers. The revised manuscript has been modified quite a a lot,
and it has also improved. I still have some comments concerning the new version:
Whole manuscript:
Please re-check the grammar (for instance on rows 50, 66, 73-77).
Please use certain words in the same way throughout the text (celiac disease, gluten-free diet etc).
Re-check the correct use of abbreviations (for instance on rows 199&208 etc).
Abstract:
In the section of results; when presenting/comparing the different risks, could you mention also
the comparing group (reference individuals)?
How the results of this study may increase the incentive for implementation of large-scale
screening programs for CD?
Introduction:
At least the rows 90-97 should be moved to the section of Methods.
Table 1:
Abbreviations (ICD, IMRD) should be explained.
Results:
I kindly suggest presenting the results of risks using HRs, probably not CIs. For instance, on the
row 153, an increased risk would be over three-fold.
Figure 1:
I recommend changing the word “ALL_IMRD”.
Discussion:
In my opinion, no need to refer to tables in the discussion section.
Do the authors have any explanations for the finding that the risk was increased for nephrotic
syndrome, systemic lupus erythematosus, tubulointerstitial nephritis, and unspecific nephritis
and nephropathy following the CD diagnosis? Please consider having a discussion about it in
the text.
Please review this paper.
user
Title: Unraveling the role of early coeliac disease diagnosis in the risk of developing immune-
mediated renal diseases
Version: 2 Date: 06 Oct 2024
Reviewer's report:
Reviewer's report:
I thank the authors for their answers. The revised manuscript has been modified quite a a lot,
and it has also improved. I still have some comments concerning the new version:
Whole manuscript:
Please re-check the grammar (for instance on rows 50, 66, 73-77).
Please use certain words in the same way throughout the text (celiac disease, gluten-free diet etc).
Re-check the correct use of abbreviations (for instance on rows 199&208 etc).
Abstract:
In the section of results; when presenting/comparing the different risks, could you mention also
the comparing group (reference individuals)?
How the results of this study may increase the incentive for implementation of large-scale
screening programs for CD?
Introduction:
At least the rows 90-97 should be moved to the section of Methods.
Table 1:
Abbreviations (ICD, IMRD) should be explained.
Results:
I kindly suggest presenting the results of risks using HRs, probably not CIs. For instance, on the
row 153, an increased risk would be over three-fold.
Figure 1:
I recommend changing the word “ALL_IMRD”.
Discussion:
In my opinion, no need to refer to tables in the discussion section.
Do the authors have any explanations for the finding that the risk was increased for nephrotic
syndrome, systemic lupus erythematosus, tubulointerstitial nephritis, and unspecific nephritis
and nephropathy following the CD diagnosis? Please consider having a discussion about it in
the text.
assistant