Title: Heparin-binding protein is significantly increased in acute pancreatitis
Version: 1 Date: 10 May 2021
Reviewer's report:
This is a valid point to explore new biomarkers and their association with the clinical course of
AP. However, there are a few issues that need to be addressed:
1- The rationale behind HBP is not well explained in this manuscript. The paper will benefit
from adding an IV fluid treatment variable in the multivariable analysis: The cumulative amount
of IV fluid and the type of IV fluid (Lactated ringer, Normal saline, etc) within the golden time
of intervention (the first 6 hours of hospital care) will be essential to understand the HBP in
the vascular leak.
2- The paper will benefit from an extensive linguistic review. There are a number of grammatical
errors throughout the paper. For example, in the last paragraph of results, the authors say "When
only those patients who did not received diuretics were analyzed there were still no correlation
between HBP concentration and fluid balance." the verb should change to "When only those
patients who did not receive diuretics were analyzed there were still no correlation between HBP
concentration and fluid balance."
Title: Heparin-binding protein is significantly increased in acute pancreatitis
Version: 1 Date: 10 May 2021
Reviewer's report:
This is a valid point to explore new biomarkers and their association with the clinical course of
AP. However, there are a few issues that need to be addressed:
1- The rationale behind HBP is not well explained in this manuscript. The paper will benefit
from adding an IV fluid treatment variable in the multivariable analysis: The cumulative amount
of IV fluid and the type of IV fluid (Lactated ringer, Normal saline, etc) within the golden time
of intervention (the first 6 hours of hospital care) will be essential to understand the HBP in
the vascular leak.
2- The paper will benefit from an extensive linguistic review. There are a number of grammatical
errors throughout the paper. For example, in the last paragraph of results, the authors say "When
only those patients who did not received diuretics were analyzed there were still no correlation
between HBP concentration and fluid balance." the verb should change to "When only those
patients who did not receive diuretics were analyzed there were still no correlation between HBP
concentration and fluid balance."
Please review this paper.
user
Title: Heparin-binding protein is significantly increased in acute pancreatitis
Version: 1 Date: 10 May 2021
Reviewer's report:
This is a valid point to explore new biomarkers and their association with the clinical course of
AP. However, there are a few issues that need to be addressed:
1- The rationale behind HBP is not well explained in this manuscript. The paper will benefit
from adding an IV fluid treatment variable in the multivariable analysis: The cumulative amount
of IV fluid and the type of IV fluid (Lactated ringer, Normal saline, etc) within the golden time
of intervention (the first 6 hours of hospital care) will be essential to understand the HBP in
the vascular leak.
2- The paper will benefit from an extensive linguistic review. There are a number of grammatical
errors throughout the paper. For example, in the last paragraph of results, the authors say "When
only those patients who did not received diuretics were analyzed there were still no correlation
between HBP concentration and fluid balance." the verb should change to "When only those
patients who did not receive diuretics were analyzed there were still no correlation between HBP
concentration and fluid balance."
assistant