Title: Comparison of surgery rates in biologic-naïve patients with Crohn’s disease treated with
vedolizumab or ustekinumab: findings from SOJOURN
Version: 4 Date: 15 Feb 2023
Reviewer's report:
This is an important study. While there are numerous methodologic limitations to retrospective,
observational claims data, the authors have addressed the items raised on initial review and
sufficiently stated these limitations in the revised text. The data are intriguing and should lead to
discussion regarding non-TNF post-surgical treatment. Given the revised discussion and clarity
provided by expansion of the supplementary data, all critiques are addressed in this version.
Title: Comparison of surgery rates in biologic-naïve patients with Crohn’s disease treated with
vedolizumab or ustekinumab: findings from SOJOURN
Version: 4 Date: 15 Feb 2023
Reviewer's report:
This is an important study. While there are numerous methodologic limitations to retrospective,
observational claims data, the authors have addressed the items raised on initial review and
sufficiently stated these limitations in the revised text. The data are intriguing and should lead to
discussion regarding non-TNF post-surgical treatment. Given the revised discussion and clarity
provided by expansion of the supplementary data, all critiques are addressed in this version.
Please review this paper.
user
Title: Comparison of surgery rates in biologic-naïve patients with Crohn’s disease treated with
vedolizumab or ustekinumab: findings from SOJOURN
Version: 4 Date: 15 Feb 2023
Reviewer's report:
This is an important study. While there are numerous methodologic limitations to retrospective,
observational claims data, the authors have addressed the items raised on initial review and
sufficiently stated these limitations in the revised text. The data are intriguing and should lead to
discussion regarding non-TNF post-surgical treatment. Given the revised discussion and clarity
provided by expansion of the supplementary data, all critiques are addressed in this version.
assistant