Title: Associations of patient-generated subjective global assessment (PG-SGA) and
NUTRISCORE with survival in gastric cancer patients: timing matters, a retrospective cohort
study
Version: 1 Date: 24 Jun 2022
Reviewer:  X. Zhang
Reviewer's report:
This paper explored whether the timing of the nutrition assessment was associated with survival
among gastric cancer patients.
I have several general comments:
1. The authors found that high PG-SGA scores at 2 months after gastrectomy were associated
with an increased risk of mortality for 9-11 vs. #5 of PG-SGA scores. However, the increased
risk of mortality was not significant for #12 vs. #5 of PG-SGA scores. The authors should explain
why patients with severe malnutrition status (PG-SGA scores#12) was not associated with worse
survival outcome.
2. The authors reported an inverse association for the NUTRISCORE assessed at 1 month
(median days = 32 days after surgery). The authors should explain why patients with malnutrition
risk (NUTRISCORE=5 or 6) showed lower mortality than those without malnutrition
(NUTRISCORE#4).
3. The authors reported the association between PG-SGA scores and mortality tended to persist
for third nutritional consultation. The p values should be provided for 9-11 vs. #5 of PG-SGA
scores group. Because the confidence intervals of HRs were relatively wide.
4. Anticancer treatment was an important covariate, it should be adjusted in multivariate Cox
regression analysis.
Title: Associations of patient-generated subjective global assessment (PG-SGA) and
NUTRISCORE with survival in gastric cancer patients: timing matters, a retrospective cohort
study
Version: 1 Date: 24 Jun 2022
Reviewer:  X. Zhang
Reviewer's report:
This paper explored whether the timing of the nutrition assessment was associated with survival
among gastric cancer patients.
I have several general comments:
1. The authors found that high PG-SGA scores at 2 months after gastrectomy were associated
with an increased risk of mortality for 9-11 vs. #5 of PG-SGA scores. However, the increased
risk of mortality was not significant for #12 vs. #5 of PG-SGA scores. The authors should explain
why patients with severe malnutrition status (PG-SGA scores#12) was not associated with worse
survival outcome.
2. The authors reported an inverse association for the NUTRISCORE assessed at 1 month
(median days = 32 days after surgery). The authors should explain why patients with malnutrition
risk (NUTRISCORE=5 or 6) showed lower mortality than those without malnutrition
(NUTRISCORE#4).
3. The authors reported the association between PG-SGA scores and mortality tended to persist
for third nutritional consultation. The p values should be provided for 9-11 vs. #5 of PG-SGA
scores group. Because the confidence intervals of HRs were relatively wide.
4. Anticancer treatment was an important covariate, it should be adjusted in multivariate Cox
regression analysis.
Please review this paper.
user
Title: Associations of patient-generated subjective global assessment (PG-SGA) and
NUTRISCORE with survival in gastric cancer patients: timing matters, a retrospective cohort
study
Version: 1 Date: 24 Jun 2022
Reviewer:  X. Zhang
Reviewer's report:
This paper explored whether the timing of the nutrition assessment was associated with survival
among gastric cancer patients.
I have several general comments:
1. The authors found that high PG-SGA scores at 2 months after gastrectomy were associated
with an increased risk of mortality for 9-11 vs. #5 of PG-SGA scores. However, the increased
risk of mortality was not significant for #12 vs. #5 of PG-SGA scores. The authors should explain
why patients with severe malnutrition status (PG-SGA scores#12) was not associated with worse
survival outcome.
2. The authors reported an inverse association for the NUTRISCORE assessed at 1 month
(median days = 32 days after surgery). The authors should explain why patients with malnutrition
risk (NUTRISCORE=5 or 6) showed lower mortality than those without malnutrition
(NUTRISCORE#4).
3. The authors reported the association between PG-SGA scores and mortality tended to persist
for third nutritional consultation. The p values should be provided for 9-11 vs. #5 of PG-SGA
scores group. Because the confidence intervals of HRs were relatively wide.
4. Anticancer treatment was an important covariate, it should be adjusted in multivariate Cox
regression analysis.
assistant