Reviewer's report
Title:Early liver biopsy, intraparenchymal cholestasis, and prognosis in patients
with alcoholic steatohepatitis
Version: 1Date:27 July 2011
Reviewer: Kaushal Madan
Reviewer's report:
Major revisions:
1. The authors have not described, how was the presence of infection defined?
What parameters of sepsis were considered in order to exclude the patients?
2. What were the features to define the presence of intraparenchymal
cholestasis?
3. The authors should have correlated the response to steroids, in patients with
and without intrahepatic cholestasis. This would have made this study clinically
more relevant.
4. Why did the authors not try to correlate the biochemical markers of
cholestasis, such as alkaline phosphatase and GGT or even AST, or ALT with
survival and with presence or absence of intraparenchymal cholestasis?
5. Was tests for hepatitis A done in all patients and if not why?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that i have no competing interests
Reviewer's report
Title:Early liver biopsy, intraparenchymal cholestasis, and prognosis in patients
with alcoholic steatohepatitis
Version: 1Date:27 July 2011
Reviewer: Kaushal Madan
Reviewer's report:
Major revisions:
1. The authors have not described, how was the presence of infection defined?
What parameters of sepsis were considered in order to exclude the patients?
2. What were the features to define the presence of intraparenchymal
cholestasis?
3. The authors should have correlated the response to steroids, in patients with
and without intrahepatic cholestasis. This would have made this study clinically
more relevant.
4. Why did the authors not try to correlate the biochemical markers of
cholestasis, such as alkaline phosphatase and GGT or even AST, or ALT with
survival and with presence or absence of intraparenchymal cholestasis?
5. Was tests for hepatitis A done in all patients and if not why?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that i have no competing interests
Please review this paper.
user
Reviewer's report
Title:Early liver biopsy, intraparenchymal cholestasis, and prognosis in patients
with alcoholic steatohepatitis
Version: 1Date:27 July 2011
Reviewer: Kaushal Madan
Reviewer's report:
Major revisions:
1. The authors have not described, how was the presence of infection defined?
What parameters of sepsis were considered in order to exclude the patients?
2. What were the features to define the presence of intraparenchymal
cholestasis?
3. The authors should have correlated the response to steroids, in patients with
and without intrahepatic cholestasis. This would have made this study clinically
more relevant.
4. Why did the authors not try to correlate the biochemical markers of
cholestasis, such as alkaline phosphatase and GGT or even AST, or ALT with
survival and with presence or absence of intraparenchymal cholestasis?
5. Was tests for hepatitis A done in all patients and if not why?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that i have no competing interests
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