Reviewer's report
Title:Acid Suppress Agents and Risk of Mycobacterium Tuberculosis: A
Population-Based, Case-Control Study
Version:2Date:11 March 2014
Reviewer: Puja Myles
Reviewer's report:
Most of my comments have been addressed but two minor points need to be
addressed:
1. The authors have acknowledged in the response that they did not further
investigate long term versus short term acid suppressant therapy. This is fine but
must be acknowledged in the discussion as a gap that needs to be addressed by
future research.
2. The multivariable model building strategy is still not clear in the methods. I
suggest that the methods include a list of a priori covariates/confounder
variables. If all these a priori covariates were included in the multivariable model,
then please say so clearly. If on the other hand, a statistical selection procedure
was used to determine a more parsimonious model, then please state this and
clarify what the statistical selection procedure was.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have received an unrestricted educational grant from F. Hoffman- La Roche for
research in the area of pandemic influenza. This is not related in any way to the
content of the paper I have reviewed.
Reviewer's report
Title:Acid Suppress Agents and Risk of Mycobacterium Tuberculosis: A
Population-Based, Case-Control Study
Version:2Date:11 March 2014
Reviewer: Puja Myles
Reviewer's report:
Most of my comments have been addressed but two minor points need to be
addressed:
1. The authors have acknowledged in the response that they did not further
investigate long term versus short term acid suppressant therapy. This is fine but
must be acknowledged in the discussion as a gap that needs to be addressed by
future research.
2. The multivariable model building strategy is still not clear in the methods. I
suggest that the methods include a list of a priori covariates/confounder
variables. If all these a priori covariates were included in the multivariable model,
then please say so clearly. If on the other hand, a statistical selection procedure
was used to determine a more parsimonious model, then please state this and
clarify what the statistical selection procedure was.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have received an unrestricted educational grant from F. Hoffman- La Roche for
research in the area of pandemic influenza. This is not related in any way to the
content of the paper I have reviewed.
Please review this paper.
user
Reviewer's report
Title:Acid Suppress Agents and Risk of Mycobacterium Tuberculosis: A
Population-Based, Case-Control Study
Version:2Date:11 March 2014
Reviewer: Puja Myles
Reviewer's report:
Most of my comments have been addressed but two minor points need to be
addressed:
1. The authors have acknowledged in the response that they did not further
investigate long term versus short term acid suppressant therapy. This is fine but
must be acknowledged in the discussion as a gap that needs to be addressed by
future research.
2. The multivariable model building strategy is still not clear in the methods. I
suggest that the methods include a list of a priori covariates/confounder
variables. If all these a priori covariates were included in the multivariable model,
then please say so clearly. If on the other hand, a statistical selection procedure
was used to determine a more parsimonious model, then please state this and
clarify what the statistical selection procedure was.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have received an unrestricted educational grant from F. Hoffman- La Roche for
research in the area of pandemic influenza. This is not related in any way to the
content of the paper I have reviewed.
assistant