Reviewer's report
Title:Usefulness and safety of 0.4 percent sodium hyaluronate solution as a
submucosal fluid cushion for endoscopic resection of colorectal mucosal
neoplasms: A prospective multi-center open-label trial
Version: 2Date:15 October 2008
Reviewer: alessandro A repici
Reviewer's report:
Despite the revision made by the authors and the extensive explanations
reported in the point-by-point response, the limitations and the bias of the study
remain unchanged with relatively high impact on the scientific or technical value
of the paper.
The study design, the small sample size, the different dilution of HA used (please
see response to reviewer 1 in which the authors declare that a subgroup of
patients was treated with HA diluted with indigo carmine and another subgroup
with epinephrine), the different techniques of polyp resection used as well as the
subjective evaluation score of the HA performance make the results of the study
still too weak and hard to translate in significant meaningful value.
To my opinion and according to the comments and doubts raised by the other
reviewers this study is not completely appropriate to be published on the journal
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interests
Reviewer's report
Title:Usefulness and safety of 0.4 percent sodium hyaluronate solution as a
submucosal fluid cushion for endoscopic resection of colorectal mucosal
neoplasms: A prospective multi-center open-label trial
Version: 2Date:15 October 2008
Reviewer: alessandro A repici
Reviewer's report:
Despite the revision made by the authors and the extensive explanations
reported in the point-by-point response, the limitations and the bias of the study
remain unchanged with relatively high impact on the scientific or technical value
of the paper.
The study design, the small sample size, the different dilution of HA used (please
see response to reviewer 1 in which the authors declare that a subgroup of
patients was treated with HA diluted with indigo carmine and another subgroup
with epinephrine), the different techniques of polyp resection used as well as the
subjective evaluation score of the HA performance make the results of the study
still too weak and hard to translate in significant meaningful value.
To my opinion and according to the comments and doubts raised by the other
reviewers this study is not completely appropriate to be published on the journal
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interests
Please review this paper.
user
Reviewer's report
Title:Usefulness and safety of 0.4 percent sodium hyaluronate solution as a
submucosal fluid cushion for endoscopic resection of colorectal mucosal
neoplasms: A prospective multi-center open-label trial
Version: 2Date:15 October 2008
Reviewer: alessandro A repici
Reviewer's report:
Despite the revision made by the authors and the extensive explanations
reported in the point-by-point response, the limitations and the bias of the study
remain unchanged with relatively high impact on the scientific or technical value
of the paper.
The study design, the small sample size, the different dilution of HA used (please
see response to reviewer 1 in which the authors declare that a subgroup of
patients was treated with HA diluted with indigo carmine and another subgroup
with epinephrine), the different techniques of polyp resection used as well as the
subjective evaluation score of the HA performance make the results of the study
still too weak and hard to translate in significant meaningful value.
To my opinion and according to the comments and doubts raised by the other
reviewers this study is not completely appropriate to be published on the journal
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interests
assistant