Title: The Effect of Solid Food Diet Therapies on the Induction and Maintenance of Remission
in Crohn’s Disease: A Systematic Review
Version: 1 Date: 06 May 2024
Reviewer's report:
This systematic review examines the effectiveness of solid food diets (without EEN or PEN) for
inducing and maintaining remission in Crohn’s disease. The analysis, based on 14 randomized
or head to head including both adult and pediatric patients.
Here are my comments to be addressed:
1. In the abstract, please distinguish more clearly between inactive and active disease.
2. The conclusion in the abstract states promising outcome for MD and CDED in inducing
remission in CD. It needs to be balance according to the quality of studies - there is one study
that didn’t separate between UC and CD in the reduction of inflammatory markers and another
study (the DINE study) failed to show improvement in inflammatory markers, and the CDED
is an unpowered pilot study.
3. Please elaborate further on the distinctions between inactive and active disease in the
background. Also, explain the role of diet, particularly PEN, in maintaining remission.
4. The focus, along with the reference, revolves around the palatability and adherence of EEN.
Please expand upon the utilization of PEN as a treatment for maintaining remission and elucidate
the rationale in including also inactive disease.
5. Correction of Typo: Line 249 contains a repetition of the word "no."
6.  In reference to the study by El Amrousy et al., correct the number of participants to 54, as
stated in the table.
7. Consider being more critical in the conclusion, particularly regarding the quality of evidence.
Also, moderate statements particularly in the absence of high quality evidence.
8. DINE study – It might be important to emphasize in the discussion that in the subset of patients
with raised CRP and FCAL at baseline, both MD and SCD failed to show improvement, which
highlights the lack of benefit of these diets in managing active CD.
Title: The Effect of Solid Food Diet Therapies on the Induction and Maintenance of Remission
in Crohn’s Disease: A Systematic Review
Version: 1 Date: 06 May 2024
Reviewer's report:
This systematic review examines the effectiveness of solid food diets (without EEN or PEN) for
inducing and maintaining remission in Crohn’s disease. The analysis, based on 14 randomized
or head to head including both adult and pediatric patients.
Here are my comments to be addressed:
1. In the abstract, please distinguish more clearly between inactive and active disease.
2. The conclusion in the abstract states promising outcome for MD and CDED in inducing
remission in CD. It needs to be balance according to the quality of studies - there is one study
that didn’t separate between UC and CD in the reduction of inflammatory markers and another
study (the DINE study) failed to show improvement in inflammatory markers, and the CDED
is an unpowered pilot study.
3. Please elaborate further on the distinctions between inactive and active disease in the
background. Also, explain the role of diet, particularly PEN, in maintaining remission.
4. The focus, along with the reference, revolves around the palatability and adherence of EEN.
Please expand upon the utilization of PEN as a treatment for maintaining remission and elucidate
the rationale in including also inactive disease.
5. Correction of Typo: Line 249 contains a repetition of the word "no."
6.  In reference to the study by El Amrousy et al., correct the number of participants to 54, as
stated in the table.
7. Consider being more critical in the conclusion, particularly regarding the quality of evidence.
Also, moderate statements particularly in the absence of high quality evidence.
8. DINE study – It might be important to emphasize in the discussion that in the subset of patients
with raised CRP and FCAL at baseline, both MD and SCD failed to show improvement, which
highlights the lack of benefit of these diets in managing active CD.
Please review this paper.
user
Title: The Effect of Solid Food Diet Therapies on the Induction and Maintenance of Remission
in Crohn’s Disease: A Systematic Review
Version: 1 Date: 06 May 2024
Reviewer's report:
This systematic review examines the effectiveness of solid food diets (without EEN or PEN) for
inducing and maintaining remission in Crohn’s disease. The analysis, based on 14 randomized
or head to head including both adult and pediatric patients.
Here are my comments to be addressed:
1. In the abstract, please distinguish more clearly between inactive and active disease.
2. The conclusion in the abstract states promising outcome for MD and CDED in inducing
remission in CD. It needs to be balance according to the quality of studies - there is one study
that didn’t separate between UC and CD in the reduction of inflammatory markers and another
study (the DINE study) failed to show improvement in inflammatory markers, and the CDED
is an unpowered pilot study.
3. Please elaborate further on the distinctions between inactive and active disease in the
background. Also, explain the role of diet, particularly PEN, in maintaining remission.
4. The focus, along with the reference, revolves around the palatability and adherence of EEN.
Please expand upon the utilization of PEN as a treatment for maintaining remission and elucidate
the rationale in including also inactive disease.
5. Correction of Typo: Line 249 contains a repetition of the word "no."
6.  In reference to the study by El Amrousy et al., correct the number of participants to 54, as
stated in the table.
7. Consider being more critical in the conclusion, particularly regarding the quality of evidence.
Also, moderate statements particularly in the absence of high quality evidence.
8. DINE study – It might be important to emphasize in the discussion that in the subset of patients
with raised CRP and FCAL at baseline, both MD and SCD failed to show improvement, which
highlights the lack of benefit of these diets in managing active CD.
assistant