Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 3 Date: 22 Aug 2022
Reviewer's report:
The authors have addressed most of the comments by reviewers.
However, minor concerns remain
1. In the introduction authors mention that “China has the highest incidence of IBD in Asia at
3.44 per 100,000 population per year, with the incidence of CD at 1.22 per 100,000 population
per year”. However, in a population based study from India, the incidence of UC was 6/100,000
population (Gut. 2003 Nov;52(11):1587-90).
2. Validation in a separate cohort could have added strength to the study. Authors should mention
this as a limitation.
3. Though the authors report very high predictive value of interferon gamma release assays, a
recent study from India reported a very poor diagnostic accuracy of IGRA in this setting (Intest
Res. 2022 Jun 13. doi: 10.5217/ir.2022.00010). Authors should discuss this study, and mention
as a limitation, about the applicability of their model in other TB endemic areas.
Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 3 Date: 22 Aug 2022
Reviewer's report:
The authors have addressed most of the comments by reviewers.
However, minor concerns remain
1. In the introduction authors mention that “China has the highest incidence of IBD in Asia at
3.44 per 100,000 population per year, with the incidence of CD at 1.22 per 100,000 population
per year”. However, in a population based study from India, the incidence of UC was 6/100,000
population (Gut. 2003 Nov;52(11):1587-90).
2. Validation in a separate cohort could have added strength to the study. Authors should mention
this as a limitation.
3. Though the authors report very high predictive value of interferon gamma release assays, a
recent study from India reported a very poor diagnostic accuracy of IGRA in this setting (Intest
Res. 2022 Jun 13. doi: 10.5217/ir.2022.00010). Authors should discuss this study, and mention
as a limitation, about the applicability of their model in other TB endemic areas.
Please review this paper.
user
Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 3 Date: 22 Aug 2022
Reviewer's report:
The authors have addressed most of the comments by reviewers.
However, minor concerns remain
1. In the introduction authors mention that “China has the highest incidence of IBD in Asia at
3.44 per 100,000 population per year, with the incidence of CD at 1.22 per 100,000 population
per year”. However, in a population based study from India, the incidence of UC was 6/100,000
population (Gut. 2003 Nov;52(11):1587-90).
2. Validation in a separate cohort could have added strength to the study. Authors should mention
this as a limitation.
3. Though the authors report very high predictive value of interferon gamma release assays, a
recent study from India reported a very poor diagnostic accuracy of IGRA in this setting (Intest
Res. 2022 Jun 13. doi: 10.5217/ir.2022.00010). Authors should discuss this study, and mention
as a limitation, about the applicability of their model in other TB endemic areas.
assistant