Reviewer's report
Title:The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated
with peptic ulcer and gastric cancer in Mexican population
Version:3Date:8 October 2014
Reviewer: Christophe BURUCOA
Reviewer's report:
The manuscript of Beltran-Anaya et al. is a single-center descriptive study
seeking in 499 mexican patients the presence of H. pylori infection and the
presence and motifs of EPIYA CagA. The search for the infection and
characterization of virulence genes is performed using PCR technology on
biopsies directly, without isolation of the bacterium in culture. They report a high
prevalence of CagA in the Mexican population. They show the statistical
relationship between the number of patterns Epiya-C and ulcerous and
cancerous diseases. The strength of this work is the large number of patients
studied. The results presented are not very original, numerous articles have
allready been published in numerous studies in the world, in South America but
never in South Mexico. The manuscript is well written, clear. Some
improvements are proposed:
• Give the dates of the patient inclusion
• Describe the analysis of electrophoretic profiles for defining patterns and
number Epiya
• Line 320 de change the
• Line 523 26 the number not in bold
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interest
Reviewer's report
Title:The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated
with peptic ulcer and gastric cancer in Mexican population
Version:3Date:8 October 2014
Reviewer: Christophe BURUCOA
Reviewer's report:
The manuscript of Beltran-Anaya et al. is a single-center descriptive study
seeking in 499 mexican patients the presence of H. pylori infection and the
presence and motifs of EPIYA CagA. The search for the infection and
characterization of virulence genes is performed using PCR technology on
biopsies directly, without isolation of the bacterium in culture. They report a high
prevalence of CagA in the Mexican population. They show the statistical
relationship between the number of patterns Epiya-C and ulcerous and
cancerous diseases. The strength of this work is the large number of patients
studied. The results presented are not very original, numerous articles have
allready been published in numerous studies in the world, in South America but
never in South Mexico. The manuscript is well written, clear. Some
improvements are proposed:
• Give the dates of the patient inclusion
• Describe the analysis of electrophoretic profiles for defining patterns and
number Epiya
• Line 320 de change the
• Line 523 26 the number not in bold
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interest
Please review this paper.
user
Reviewer's report
Title:The EPIYA-ABCC motif pattern in CagA of Helicobacter pylori is associated
with peptic ulcer and gastric cancer in Mexican population
Version:3Date:8 October 2014
Reviewer: Christophe BURUCOA
Reviewer's report:
The manuscript of Beltran-Anaya et al. is a single-center descriptive study
seeking in 499 mexican patients the presence of H. pylori infection and the
presence and motifs of EPIYA CagA. The search for the infection and
characterization of virulence genes is performed using PCR technology on
biopsies directly, without isolation of the bacterium in culture. They report a high
prevalence of CagA in the Mexican population. They show the statistical
relationship between the number of patterns Epiya-C and ulcerous and
cancerous diseases. The strength of this work is the large number of patients
studied. The results presented are not very original, numerous articles have
allready been published in numerous studies in the world, in South America but
never in South Mexico. The manuscript is well written, clear. Some
improvements are proposed:
• Give the dates of the patient inclusion
• Describe the analysis of electrophoretic profiles for defining patterns and
number Epiya
• Line 320 de change the
• Line 523 26 the number not in bold
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interest
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