Reviewer's report
Title:Hyperimmune Anti-HBs Plasma as Alternative to Commercial
Immunoglobulins for Prevention of HBV Recurrence After Liver Transplantation
Version: 1Date:13 November 2009
Reviewer: George Papatheodoridis
Reviewer's report:
There is certainly need for cheaper HBIG alternatives for HBV liver transplant
patients and therefore the subject of this study is of interest.
The design is OK and the methods and results are presented satisfactorily.
Minor essential comments
The conclusions are based on a small number of patients and should be
considered as preliminary. So, further studies are required before definite
conclusions can be drawn on this attractive approach. Thus, the conclusions of
this study should be modified and become less definite in both the abstract and
main text.
In addition, the additional use of an antiviral should be also mentioned in the
conclusions: it is not the “use of HIP that may be effective” but the “use of HIP in
combination with an oral antiviral agent”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Hyperimmune Anti-HBs Plasma as Alternative to Commercial
Immunoglobulins for Prevention of HBV Recurrence After Liver Transplantation
Version: 1Date:13 November 2009
Reviewer: George Papatheodoridis
Reviewer's report:
There is certainly need for cheaper HBIG alternatives for HBV liver transplant
patients and therefore the subject of this study is of interest.
The design is OK and the methods and results are presented satisfactorily.
Minor essential comments
The conclusions are based on a small number of patients and should be
considered as preliminary. So, further studies are required before definite
conclusions can be drawn on this attractive approach. Thus, the conclusions of
this study should be modified and become less definite in both the abstract and
main text.
In addition, the additional use of an antiviral should be also mentioned in the
conclusions: it is not the “use of HIP that may be effective” but the “use of HIP in
combination with an oral antiviral agent”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Hyperimmune Anti-HBs Plasma as Alternative to Commercial
Immunoglobulins for Prevention of HBV Recurrence After Liver Transplantation
Version: 1Date:13 November 2009
Reviewer: George Papatheodoridis
Reviewer's report:
There is certainly need for cheaper HBIG alternatives for HBV liver transplant
patients and therefore the subject of this study is of interest.
The design is OK and the methods and results are presented satisfactorily.
Minor essential comments
The conclusions are based on a small number of patients and should be
considered as preliminary. So, further studies are required before definite
conclusions can be drawn on this attractive approach. Thus, the conclusions of
this study should be modified and become less definite in both the abstract and
main text.
In addition, the additional use of an antiviral should be also mentioned in the
conclusions: it is not the “use of HIP that may be effective” but the “use of HIP in
combination with an oral antiviral agent”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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