Title: Identification and validation of a CD4 + T cell-related prognostic model to predict immune
responses in stage III-IV colorectal cancer
Version: 1 Date: 24 Nov 2024
Reviewer's report:
The authors found that a higher infiltrating abundance of CD4+ T cells may result in an
association with an improved prognosis in patients with stage III-IV CRC.And the authors
identified a set of CD4+ T-cell-related prognostic features that could predict prognosis and
response to immunotherapy in patients with stage III-IV CRC. That was a good job.That's a
good job, but there are still some concerns that need to be further elucidated by the authors.
1. The author should improve the logic of writing#such as“Finally…More importantly…
Furthermore”in the abstract.
2.The first sentence of the Introduction, regarding the colorectal cancer statisics should contain
an updated reference.
3.In Fig8, the authors described that ANXA2 was mainly expressed in Tregs, but there was no
obvious co-expression of ANXA2 and FOXP3 in Fig8E.
4.Should the author require additional evidence to further substantiate the claims.
Title: Identification and validation of a CD4 + T cell-related prognostic model to predict immune
responses in stage III-IV colorectal cancer
Version: 1 Date: 24 Nov 2024
Reviewer's report:
The authors found that a higher infiltrating abundance of CD4+ T cells may result in an
association with an improved prognosis in patients with stage III-IV CRC.And the authors
identified a set of CD4+ T-cell-related prognostic features that could predict prognosis and
response to immunotherapy in patients with stage III-IV CRC. That was a good job.That's a
good job, but there are still some concerns that need to be further elucidated by the authors.
1. The author should improve the logic of writing#such as“Finally…More importantly…
Furthermore”in the abstract.
2.The first sentence of the Introduction, regarding the colorectal cancer statisics should contain
an updated reference.
3.In Fig8, the authors described that ANXA2 was mainly expressed in Tregs, but there was no
obvious co-expression of ANXA2 and FOXP3 in Fig8E.
4.Should the author require additional evidence to further substantiate the claims.
Please review this paper.
user
Title: Identification and validation of a CD4 + T cell-related prognostic model to predict immune
responses in stage III-IV colorectal cancer
Version: 1 Date: 24 Nov 2024
Reviewer's report:
The authors found that a higher infiltrating abundance of CD4+ T cells may result in an
association with an improved prognosis in patients with stage III-IV CRC.And the authors
identified a set of CD4+ T-cell-related prognostic features that could predict prognosis and
response to immunotherapy in patients with stage III-IV CRC. That was a good job.That's a
good job, but there are still some concerns that need to be further elucidated by the authors.
1. The author should improve the logic of writing#such as“Finally…More importantly…
Furthermore”in the abstract.
2.The first sentence of the Introduction, regarding the colorectal cancer statisics should contain
an updated reference.
3.In Fig8, the authors described that ANXA2 was mainly expressed in Tregs, but there was no
obvious co-expression of ANXA2 and FOXP3 in Fig8E.
4.Should the author require additional evidence to further substantiate the claims.
assistant