Title: Non-Alcoholic Fatty Liver Disease in Tanzania: Prevalence, Determinants, and
Diagnostic Performance of Triglycerides-Glucose Index and Triglycerides-Glucose Index –
Body Mass Index Compared to the Hepatic Ultrasound in Overweight and Obese Individuals
Version: 0 Date: 05 Jan 2024
Reviewer's report:
It is meaningful to show the relationship between TyG and NAFLD in African population in
Tanzania. However, many similar studies have already been done in other populations in more
large number of patients (even big data).
This study only includes 181 patients, although calculated through the Kish Leslie’s formula
for cross sectional studies, seem relatively small to analyzethe predictive effect and diagnostic
value of TyG in the general population.
Overall, the study needs more  patients and more originality.
There is no specific reasoning why the TyG cutoff is set 8.99. Where did this number come
from? This paper suggested TyG and TyG-BMI as screening tool for NAFLD in overweight
and obese African population. However,  the sensitivity and positive predictive value are very
low.  To screen for a disease, the sensitivity should be much higher than presented. Therefore,
the cutoff needs to be reexamined.
Title: Non-Alcoholic Fatty Liver Disease in Tanzania: Prevalence, Determinants, and
Diagnostic Performance of Triglycerides-Glucose Index and Triglycerides-Glucose Index –
Body Mass Index Compared to the Hepatic Ultrasound in Overweight and Obese Individuals
Version: 0 Date: 05 Jan 2024
Reviewer's report:
It is meaningful to show the relationship between TyG and NAFLD in African population in
Tanzania. However, many similar studies have already been done in other populations in more
large number of patients (even big data).
This study only includes 181 patients, although calculated through the Kish Leslie’s formula
for cross sectional studies, seem relatively small to analyzethe predictive effect and diagnostic
value of TyG in the general population.
Overall, the study needs more  patients and more originality.
There is no specific reasoning why the TyG cutoff is set 8.99. Where did this number come
from? This paper suggested TyG and TyG-BMI as screening tool for NAFLD in overweight
and obese African population. However,  the sensitivity and positive predictive value are very
low.  To screen for a disease, the sensitivity should be much higher than presented. Therefore,
the cutoff needs to be reexamined.
Please review this paper.
user
Title: Non-Alcoholic Fatty Liver Disease in Tanzania: Prevalence, Determinants, and
Diagnostic Performance of Triglycerides-Glucose Index and Triglycerides-Glucose Index –
Body Mass Index Compared to the Hepatic Ultrasound in Overweight and Obese Individuals
Version: 0 Date: 05 Jan 2024
Reviewer's report:
It is meaningful to show the relationship between TyG and NAFLD in African population in
Tanzania. However, many similar studies have already been done in other populations in more
large number of patients (even big data).
This study only includes 181 patients, although calculated through the Kish Leslie’s formula
for cross sectional studies, seem relatively small to analyzethe predictive effect and diagnostic
value of TyG in the general population.
Overall, the study needs more  patients and more originality.
There is no specific reasoning why the TyG cutoff is set 8.99. Where did this number come
from? This paper suggested TyG and TyG-BMI as screening tool for NAFLD in overweight
and obese African population. However,  the sensitivity and positive predictive value are very
low.  To screen for a disease, the sensitivity should be much higher than presented. Therefore,
the cutoff needs to be reexamined.
assistant