Reviewer's report
Title:Association of genetic variations in GNB1 with response to peginterferon
plus ribavirin therapy for chronic hepatitis C in a Chinese population in Taiwan
Version: 1Date:24 September 2012
Reviewer: Mahmoud Khattab
Reviewer's report:
Comments to authors:
1Major Comulsory Revision:-In discussion,you have presented a paragraph
discussing data concernedwith your study resuls regarding SVR in both HCV-1
and HCV-2,and you mentioned that there was no correlation between
polymorphism in GNB1,the gene you have studied and SVR.Then why have you
adressed your artcle by:
impact of this gene on RVR?and then presenting evidence that RVR predicts
SVR to justify your preliminary results concerning confusing relations between
GNB1 gene polymorphism.
2-Major Comulsory Revision:-When a clinician tries to read your manuscript he
will be confused by the way you have presented and discussed your data.for
example,you mentioned that the distribution of different alleles was not different
from RVR(+)and
RVR(-) Patients,and then you stated that thedosage effect of Gallele at
rs12126768 was inversely correlated to RVR in HCV1.
What is meant by dose effect?,Have this any value? you have not explained all
these questions in discussion.
3-Major Compulsory Revision:There is much overlap in the manuscript by using
numbers rather than letters(A,C,G,T) to indicate the individual alleles,it was more
simplified towrite in the letter form.
4-Minor Revision:-What is meant by GNB1 halotype?and what is its
significance?in relation to prediction of response.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Association of genetic variations in GNB1 with response to peginterferon
plus ribavirin therapy for chronic hepatitis C in a Chinese population in Taiwan
Version: 1Date:24 September 2012
Reviewer: Mahmoud Khattab
Reviewer's report:
Comments to authors:
1Major Comulsory Revision:-In discussion,you have presented a paragraph
discussing data concernedwith your study resuls regarding SVR in both HCV-1
and HCV-2,and you mentioned that there was no correlation between
polymorphism in GNB1,the gene you have studied and SVR.Then why have you
adressed your artcle by:
impact of this gene on RVR?and then presenting evidence that RVR predicts
SVR to justify your preliminary results concerning confusing relations between
GNB1 gene polymorphism.
2-Major Comulsory Revision:-When a clinician tries to read your manuscript he
will be confused by the way you have presented and discussed your data.for
example,you mentioned that the distribution of different alleles was not different
from RVR(+)and
RVR(-) Patients,and then you stated that thedosage effect of Gallele at
rs12126768 was inversely correlated to RVR in HCV1.
What is meant by dose effect?,Have this any value? you have not explained all
these questions in discussion.
3-Major Compulsory Revision:There is much overlap in the manuscript by using
numbers rather than letters(A,C,G,T) to indicate the individual alleles,it was more
simplified towrite in the letter form.
4-Minor Revision:-What is meant by GNB1 halotype?and what is its
significance?in relation to prediction of response.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Association of genetic variations in GNB1 with response to peginterferon
plus ribavirin therapy for chronic hepatitis C in a Chinese population in Taiwan
Version: 1Date:24 September 2012
Reviewer: Mahmoud Khattab
Reviewer's report:
Comments to authors:
1Major Comulsory Revision:-In discussion,you have presented a paragraph
discussing data concernedwith your study resuls regarding SVR in both HCV-1
and HCV-2,and you mentioned that there was no correlation between
polymorphism in GNB1,the gene you have studied and SVR.Then why have you
adressed your artcle by:
impact of this gene on RVR?and then presenting evidence that RVR predicts
SVR to justify your preliminary results concerning confusing relations between
GNB1 gene polymorphism.
2-Major Comulsory Revision:-When a clinician tries to read your manuscript he
will be confused by the way you have presented and discussed your data.for
example,you mentioned that the distribution of different alleles was not different
from RVR(+)and
RVR(-) Patients,and then you stated that thedosage effect of Gallele at
rs12126768 was inversely correlated to RVR in HCV1.
What is meant by dose effect?,Have this any value? you have not explained all
these questions in discussion.
3-Major Compulsory Revision:There is much overlap in the manuscript by using
numbers rather than letters(A,C,G,T) to indicate the individual alleles,it was more
simplified towrite in the letter form.
4-Minor Revision:-What is meant by GNB1 halotype?and what is its
significance?in relation to prediction of response.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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