Title: High-Dose Polyethylene Glycol-3350 and Gatorade Solutions for Patients with Previous
Inadequate Bowel Preparations for Colonoscopy are Safe and Effective
Version: 2 Date: 06 Nov 2022
Reviewer:  Keng Hoong Chiam
Reviewer's report:
This study looks at the role of using high-dose PEG with Gatorade solutions in patients whose
previous colonoscopic assessments were substandard due to inadequate bowel preparation. It is
the first of its kind to venture into using higher-than-usual bowel preparation formulation and
compare it against historical controls from a previous study by similar authors. I commend their
effort in looking for novel alternatives to tackle such common issues faced by endoscopists daily.
Per the limitations mentioned, this is not a randomised study, and the patients selected to undergo
the colonoscopy have had some experience with taking bowel preparation. They would thus be
more careful in overseeing their diet and be more adherent to the prescribed bowel preparation
regime for fear of missed lesions. The use of historical controls would also hinder the impact of
the study as the population chosen was different (younger). Nevertheless, I understand the need
for such a comparison owing to the unique population studied. My concern for this study is the
low patient numbers, risk of confounding factors and the lack of blinding for the subjects. These
issues may give rise to a risk of bias. Despite these concerns, the study methodology is clear and
sets a good foundation for future researchers to look into how investigators can take this further.
Title: High-Dose Polyethylene Glycol-3350 and Gatorade Solutions for Patients with Previous
Inadequate Bowel Preparations for Colonoscopy are Safe and Effective
Version: 2 Date: 06 Nov 2022
Reviewer:  Keng Hoong Chiam
Reviewer's report:
This study looks at the role of using high-dose PEG with Gatorade solutions in patients whose
previous colonoscopic assessments were substandard due to inadequate bowel preparation. It is
the first of its kind to venture into using higher-than-usual bowel preparation formulation and
compare it against historical controls from a previous study by similar authors. I commend their
effort in looking for novel alternatives to tackle such common issues faced by endoscopists daily.
Per the limitations mentioned, this is not a randomised study, and the patients selected to undergo
the colonoscopy have had some experience with taking bowel preparation. They would thus be
more careful in overseeing their diet and be more adherent to the prescribed bowel preparation
regime for fear of missed lesions. The use of historical controls would also hinder the impact of
the study as the population chosen was different (younger). Nevertheless, I understand the need
for such a comparison owing to the unique population studied. My concern for this study is the
low patient numbers, risk of confounding factors and the lack of blinding for the subjects. These
issues may give rise to a risk of bias. Despite these concerns, the study methodology is clear and
sets a good foundation for future researchers to look into how investigators can take this further.
Please review this paper.
user
Title: High-Dose Polyethylene Glycol-3350 and Gatorade Solutions for Patients with Previous
Inadequate Bowel Preparations for Colonoscopy are Safe and Effective
Version: 2 Date: 06 Nov 2022
Reviewer:  Keng Hoong Chiam
Reviewer's report:
This study looks at the role of using high-dose PEG with Gatorade solutions in patients whose
previous colonoscopic assessments were substandard due to inadequate bowel preparation. It is
the first of its kind to venture into using higher-than-usual bowel preparation formulation and
compare it against historical controls from a previous study by similar authors. I commend their
effort in looking for novel alternatives to tackle such common issues faced by endoscopists daily.
Per the limitations mentioned, this is not a randomised study, and the patients selected to undergo
the colonoscopy have had some experience with taking bowel preparation. They would thus be
more careful in overseeing their diet and be more adherent to the prescribed bowel preparation
regime for fear of missed lesions. The use of historical controls would also hinder the impact of
the study as the population chosen was different (younger). Nevertheless, I understand the need
for such a comparison owing to the unique population studied. My concern for this study is the
low patient numbers, risk of confounding factors and the lack of blinding for the subjects. These
issues may give rise to a risk of bias. Despite these concerns, the study methodology is clear and
sets a good foundation for future researchers to look into how investigators can take this further.
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