Reviewer's report
Title:Metabonomics analysis of liver tissues in
d-galactosamine/lipopolysaccharide induced acute hepatic failure BALB/c mice
Version: 1Date:2 October 2012
Reviewer: Bo Feng
Reviewer's report:
1.In the Establishment of ALF mode part the authors describe how the ALF
models were prepared with slight modification#is there a unified standard#Is the
conclusion suitable for different stages of ALF#Please show this data.
2.In the methods section, test repeatability of GC/TOFMS system--no mention is
made of the same sample-If then can carry on the repeated test.
3.Hepatic failure metabolites were diverse, and have individual differences,we
did not find comparison of the same individual metabolic product index ,before
and after the processing of liver failure.
4.when performing detection: were investigators blinded to the type of mice?
Were the samples based on the same part of the liver? Was the damage degree
the same?
5.The statistical analysis - comparison of the two samples, Pay attention to
sample size, Whether they have statistical significance.
6.discussion needs to be shortened.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Metabonomics analysis of liver tissues in
d-galactosamine/lipopolysaccharide induced acute hepatic failure BALB/c mice
Version: 1Date:2 October 2012
Reviewer: Bo Feng
Reviewer's report:
1.In the Establishment of ALF mode part the authors describe how the ALF
models were prepared with slight modification#is there a unified standard#Is the
conclusion suitable for different stages of ALF#Please show this data.
2.In the methods section, test repeatability of GC/TOFMS system--no mention is
made of the same sample-If then can carry on the repeated test.
3.Hepatic failure metabolites were diverse, and have individual differences,we
did not find comparison of the same individual metabolic product index ,before
and after the processing of liver failure.
4.when performing detection: were investigators blinded to the type of mice?
Were the samples based on the same part of the liver? Was the damage degree
the same?
5.The statistical analysis - comparison of the two samples, Pay attention to
sample size, Whether they have statistical significance.
6.discussion needs to be shortened.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Metabonomics analysis of liver tissues in
d-galactosamine/lipopolysaccharide induced acute hepatic failure BALB/c mice
Version: 1Date:2 October 2012
Reviewer: Bo Feng
Reviewer's report:
1.In the Establishment of ALF mode part the authors describe how the ALF
models were prepared with slight modification#is there a unified standard#Is the
conclusion suitable for different stages of ALF#Please show this data.
2.In the methods section, test repeatability of GC/TOFMS system--no mention is
made of the same sample-If then can carry on the repeated test.
3.Hepatic failure metabolites were diverse, and have individual differences,we
did not find comparison of the same individual metabolic product index ,before
and after the processing of liver failure.
4.when performing detection: were investigators blinded to the type of mice?
Were the samples based on the same part of the liver? Was the damage degree
the same?
5.The statistical analysis - comparison of the two samples, Pay attention to
sample size, Whether they have statistical significance.
6.discussion needs to be shortened.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant