Reviewer's report
Title:Estradiol deficiency in men with Crohn's disease is not associated with
reduced bone mineral density
Version: 1Date:12 August 2008
Reviewer: Herbert Tilg
Reviewer's report:
Congratulations on a fine manuscript. I thoroughly enjoyed reading this paper. I
do have a few suggestions which may improve this work.
Minor Comments:
There is a quite high percentage of current corticosteroid users (35.7%); this is
surprising looking at the duration of disease: please also include number of
patients receiving azathioprine and/or anti-TNF drugs.
Abstract: explain ICTP; include number of controls
Introduction/Discussion: also include a few sentences on the potential role of
inflammatory mediators in the pathogenesis of bone loss. Any correlations of sex
hormones and bone metabolism parameters with CRP levels?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Estradiol deficiency in men with Crohn's disease is not associated with
reduced bone mineral density
Version: 1Date:12 August 2008
Reviewer: Herbert Tilg
Reviewer's report:
Congratulations on a fine manuscript. I thoroughly enjoyed reading this paper. I
do have a few suggestions which may improve this work.
Minor Comments:
There is a quite high percentage of current corticosteroid users (35.7%); this is
surprising looking at the duration of disease: please also include number of
patients receiving azathioprine and/or anti-TNF drugs.
Abstract: explain ICTP; include number of controls
Introduction/Discussion: also include a few sentences on the potential role of
inflammatory mediators in the pathogenesis of bone loss. Any correlations of sex
hormones and bone metabolism parameters with CRP levels?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Estradiol deficiency in men with Crohn's disease is not associated with
reduced bone mineral density
Version: 1Date:12 August 2008
Reviewer: Herbert Tilg
Reviewer's report:
Congratulations on a fine manuscript. I thoroughly enjoyed reading this paper. I
do have a few suggestions which may improve this work.
Minor Comments:
There is a quite high percentage of current corticosteroid users (35.7%); this is
surprising looking at the duration of disease: please also include number of
patients receiving azathioprine and/or anti-TNF drugs.
Abstract: explain ICTP; include number of controls
Introduction/Discussion: also include a few sentences on the potential role of
inflammatory mediators in the pathogenesis of bone loss. Any correlations of sex
hormones and bone metabolism parameters with CRP levels?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant