Title: A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized
cirrhotic patients: A MIMIC database analysis
Version: 3 Date: 23 Jun 2024
Reviewer's report:
The author reports that they developed and validated a dynamic online nomogram which can
be an easy-to-use tool for predicting the individualized risk of AKI in critically ill patients with
cirrhosis. It is interesting; however, I had a few questions about this study.
1. For AKI study, how to definite the baseline serum creatinine is important and should be
provided.
2. It is better to provide how many patients whose variables >20% missing values were excluded.
3. In the manuscript, the author showed that the final logistic model incorporated five
independent predictors (MAP, UV, WBC, TB, and GCS) and was developed as a simple-to-
use nomogram.
(1) As SOFA score includes the GCS score, I am confused why did the author select both these
two score as two potential risk factors?
(2) Urine volume per se is one of the diagnosis criteria for AKI, it seems not suitable be a
potential risk factor for AKI.
4. Since different kinds of antibiotics have different renal toxicity, the author should provide
more detail about the use of antibiotic.
5. As we know, chronic hypertension can also impair renal function, but the Table 1 showed that
patients without AKI had a higher proportion of hypertension [190 (37.3%) vs. 243 (31.4%),
P=0.029].Can the author explain why?
Title: A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized
cirrhotic patients: A MIMIC database analysis
Version: 3 Date: 23 Jun 2024
Reviewer's report:
The author reports that they developed and validated a dynamic online nomogram which can
be an easy-to-use tool for predicting the individualized risk of AKI in critically ill patients with
cirrhosis. It is interesting; however, I had a few questions about this study.
1. For AKI study, how to definite the baseline serum creatinine is important and should be
provided.
2. It is better to provide how many patients whose variables >20% missing values were excluded.
3. In the manuscript, the author showed that the final logistic model incorporated five
independent predictors (MAP, UV, WBC, TB, and GCS) and was developed as a simple-to-
use nomogram.
(1) As SOFA score includes the GCS score, I am confused why did the author select both these
two score as two potential risk factors?
(2) Urine volume per se is one of the diagnosis criteria for AKI, it seems not suitable be a
potential risk factor for AKI.
4. Since different kinds of antibiotics have different renal toxicity, the author should provide
more detail about the use of antibiotic.
5. As we know, chronic hypertension can also impair renal function, but the Table 1 showed that
patients without AKI had a higher proportion of hypertension [190 (37.3%) vs. 243 (31.4%),
P=0.029].Can the author explain why?
Please review this paper.
user
Title: A dynamic model to predict early occurrence of acute kidney injury in ICU hospitalized
cirrhotic patients: A MIMIC database analysis
Version: 3 Date: 23 Jun 2024
Reviewer's report:
The author reports that they developed and validated a dynamic online nomogram which can
be an easy-to-use tool for predicting the individualized risk of AKI in critically ill patients with
cirrhosis. It is interesting; however, I had a few questions about this study.
1. For AKI study, how to definite the baseline serum creatinine is important and should be
provided.
2. It is better to provide how many patients whose variables >20% missing values were excluded.
3. In the manuscript, the author showed that the final logistic model incorporated five
independent predictors (MAP, UV, WBC, TB, and GCS) and was developed as a simple-to-
use nomogram.
(1) As SOFA score includes the GCS score, I am confused why did the author select both these
two score as two potential risk factors?
(2) Urine volume per se is one of the diagnosis criteria for AKI, it seems not suitable be a
potential risk factor for AKI.
4. Since different kinds of antibiotics have different renal toxicity, the author should provide
more detail about the use of antibiotic.
5. As we know, chronic hypertension can also impair renal function, but the Table 1 showed that
patients without AKI had a higher proportion of hypertension [190 (37.3%) vs. 243 (31.4%),
P=0.029].Can the author explain why?
assistant