Reviewer's report
Title:The comparison of grey-scale ultrasonic and clinical features of
hepatoblastoma and hepatocellular carcinoma in children: a retrospective study
for ten years
Version: 1Date:20 December 2010
Reviewer: Radu Ion Badea
Reviewer's report:
In general this is an honest study related to an important topic and realized by a
group with practical experience. The aims are well defined; the methodology of
research and the results are credible. The conclusions are appropriate. The weak
points are related to the leak of Doppler evaluation, CEUS (even limited in
indication for children’s!), elastography that are recently introduced into the
practice. Even the pathology is quite rare, and there is a retrospective study, the
leak of the above technical points makes the study a little bit "historical"
I wish to stress that in the introduction the past is used instead of relation to the
actual experience as the literature is presenting it! e.g. "Two-thirds of the
pediatric primary liver tumors were malignant [1, 2]. Hepatoblastoma (HBL)
accounted for 40-60% of the liver tumors in children, which was the most
common malignant liver tumor in children [1, 3]. Hepatocellular carcinoma (HCC)
accounted for about 20%, which was the second most common malignant liver
tumor in children [1, 4]. The two malignant liver tumors had some similar clinical
and imaging features but the prognosis and treatments were quite different. " I
suggest to the author to make appropriate revisions.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:The comparison of grey-scale ultrasonic and clinical features of
hepatoblastoma and hepatocellular carcinoma in children: a retrospective study
for ten years
Version: 1Date:20 December 2010
Reviewer: Radu Ion Badea
Reviewer's report:
In general this is an honest study related to an important topic and realized by a
group with practical experience. The aims are well defined; the methodology of
research and the results are credible. The conclusions are appropriate. The weak
points are related to the leak of Doppler evaluation, CEUS (even limited in
indication for children’s!), elastography that are recently introduced into the
practice. Even the pathology is quite rare, and there is a retrospective study, the
leak of the above technical points makes the study a little bit "historical"
I wish to stress that in the introduction the past is used instead of relation to the
actual experience as the literature is presenting it! e.g. "Two-thirds of the
pediatric primary liver tumors were malignant [1, 2]. Hepatoblastoma (HBL)
accounted for 40-60% of the liver tumors in children, which was the most
common malignant liver tumor in children [1, 3]. Hepatocellular carcinoma (HCC)
accounted for about 20%, which was the second most common malignant liver
tumor in children [1, 4]. The two malignant liver tumors had some similar clinical
and imaging features but the prognosis and treatments were quite different. " I
suggest to the author to make appropriate revisions.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:The comparison of grey-scale ultrasonic and clinical features of
hepatoblastoma and hepatocellular carcinoma in children: a retrospective study
for ten years
Version: 1Date:20 December 2010
Reviewer: Radu Ion Badea
Reviewer's report:
In general this is an honest study related to an important topic and realized by a
group with practical experience. The aims are well defined; the methodology of
research and the results are credible. The conclusions are appropriate. The weak
points are related to the leak of Doppler evaluation, CEUS (even limited in
indication for children’s!), elastography that are recently introduced into the
practice. Even the pathology is quite rare, and there is a retrospective study, the
leak of the above technical points makes the study a little bit "historical"
I wish to stress that in the introduction the past is used instead of relation to the
actual experience as the literature is presenting it! e.g. "Two-thirds of the
pediatric primary liver tumors were malignant [1, 2]. Hepatoblastoma (HBL)
accounted for 40-60% of the liver tumors in children, which was the most
common malignant liver tumor in children [1, 3]. Hepatocellular carcinoma (HCC)
accounted for about 20%, which was the second most common malignant liver
tumor in children [1, 4]. The two malignant liver tumors had some similar clinical
and imaging features but the prognosis and treatments were quite different. " I
suggest to the author to make appropriate revisions.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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