Title: The Diagnostic Value of MRI-PDFF in Hepatic Steatosis of Patients with metabolic
dysfunction-associated steatotic liver disease: A Systematic Review and Meta-Analysis
Version: 1 Date: 11 Mar 2025
Reviewer:  Ioan Sporea
Reviewer's report:
This is an important meta-analysis with implication for practice. Despite in this moment we
have many methods for ultrasound based fatty quantification, in some geographical areas, like
USA, MRI-PDFF is used in many patients (this maybe in connection with high grade obesity
of the patients). This meta-analysis is well made, with quite a good number of subjects. The
only concern is about the terminology: from 2023 (Rinella paper) we use the term of MASLD
that replaced NAFLD. Despite the papers that you used in this meta-analysis come from the era
when the term of NAFLD (and NASH) was used, you must discuss about the new nomenclature
in the paper, to have a modern paper!
Title: The Diagnostic Value of MRI-PDFF in Hepatic Steatosis of Patients with metabolic
dysfunction-associated steatotic liver disease: A Systematic Review and Meta-Analysis
Version: 1 Date: 11 Mar 2025
Reviewer:  Ioan Sporea
Reviewer's report:
This is an important meta-analysis with implication for practice. Despite in this moment we
have many methods for ultrasound based fatty quantification, in some geographical areas, like
USA, MRI-PDFF is used in many patients (this maybe in connection with high grade obesity
of the patients). This meta-analysis is well made, with quite a good number of subjects. The
only concern is about the terminology: from 2023 (Rinella paper) we use the term of MASLD
that replaced NAFLD. Despite the papers that you used in this meta-analysis come from the era
when the term of NAFLD (and NASH) was used, you must discuss about the new nomenclature
in the paper, to have a modern paper!
Please review this paper.
user
Title: The Diagnostic Value of MRI-PDFF in Hepatic Steatosis of Patients with metabolic
dysfunction-associated steatotic liver disease: A Systematic Review and Meta-Analysis
Version: 1 Date: 11 Mar 2025
Reviewer:  Ioan Sporea
Reviewer's report:
This is an important meta-analysis with implication for practice. Despite in this moment we
have many methods for ultrasound based fatty quantification, in some geographical areas, like
USA, MRI-PDFF is used in many patients (this maybe in connection with high grade obesity
of the patients). This meta-analysis is well made, with quite a good number of subjects. The
only concern is about the terminology: from 2023 (Rinella paper) we use the term of MASLD
that replaced NAFLD. Despite the papers that you used in this meta-analysis come from the era
when the term of NAFLD (and NASH) was used, you must discuss about the new nomenclature
in the paper, to have a modern paper!
assistant