Reviewer's report
Title:IGF-1 attenuates portal hypertension by decreasing portal vein endotoxin
via regulating intestinal tight junctions in cirrhotic rats
Version:4Date:24 March 2015
Reviewer: Vicente Lorenzo-Zúñiga García
Reviewer's report:
I have the opportunity to review this manuscript focused on beneficial effects of
external administration of IGF-I in cirrhotic rats. The authors have demostrated
that IGF-1 improves intestinal barrier function by increasing intestinal claudin-1
and occludin expressions and attenuatin tight junction dysfunction in intestines of
cirrhotic rats. This is important because till now we only known that IGF-I
enhances intestinal barrier function and reduces endotoxemia, bacterial
traslocation and portal pressure in cirrhotic rats
Major revision: Any
Minor revision: some gramatical mistakes (IFG-I instead of IGF-I)
In my opinion the manuscript is well done and the discusion is concise.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have competing interests
Reviewer's report
Title:IGF-1 attenuates portal hypertension by decreasing portal vein endotoxin
via regulating intestinal tight junctions in cirrhotic rats
Version:4Date:24 March 2015
Reviewer: Vicente Lorenzo-Zúñiga García
Reviewer's report:
I have the opportunity to review this manuscript focused on beneficial effects of
external administration of IGF-I in cirrhotic rats. The authors have demostrated
that IGF-1 improves intestinal barrier function by increasing intestinal claudin-1
and occludin expressions and attenuatin tight junction dysfunction in intestines of
cirrhotic rats. This is important because till now we only known that IGF-I
enhances intestinal barrier function and reduces endotoxemia, bacterial
traslocation and portal pressure in cirrhotic rats
Major revision: Any
Minor revision: some gramatical mistakes (IFG-I instead of IGF-I)
In my opinion the manuscript is well done and the discusion is concise.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have competing interests
Please review this paper.
user
Reviewer's report
Title:IGF-1 attenuates portal hypertension by decreasing portal vein endotoxin
via regulating intestinal tight junctions in cirrhotic rats
Version:4Date:24 March 2015
Reviewer: Vicente Lorenzo-Zúñiga García
Reviewer's report:
I have the opportunity to review this manuscript focused on beneficial effects of
external administration of IGF-I in cirrhotic rats. The authors have demostrated
that IGF-1 improves intestinal barrier function by increasing intestinal claudin-1
and occludin expressions and attenuatin tight junction dysfunction in intestines of
cirrhotic rats. This is important because till now we only known that IGF-I
enhances intestinal barrier function and reduces endotoxemia, bacterial
traslocation and portal pressure in cirrhotic rats
Major revision: Any
Minor revision: some gramatical mistakes (IFG-I instead of IGF-I)
In my opinion the manuscript is well done and the discusion is concise.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have competing interests
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