Reviewer's report
Title:The effect of sulindac, a non-steroidal anti-inflammatory drug, attenuates
inflammation and fibrosis in a mouse model of chronic pancreatitis
Version: 5Date:17 July 2012
Reviewer: Matthias Sendler
Reviewer's report:
The authors change the discussion in a way to explain their result more in the
context to chronic pancreatitis, this makes the paper more conclusive. They can
show a direct effect of sulindac on fibrosis development and the general immune
response. The paper is well written and sounds fine.
The question are mainly answered by the authors, they can show an effect of
sulindac on the activation of stellate cells by the activation marker alpha SMA
which is one of the key mechanisms in fibrogenesis. The influence of sulindac on
the immune regulation could be shown by real-time PCR as well as in western
blot analysis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:The effect of sulindac, a non-steroidal anti-inflammatory drug, attenuates
inflammation and fibrosis in a mouse model of chronic pancreatitis
Version: 5Date:17 July 2012
Reviewer: Matthias Sendler
Reviewer's report:
The authors change the discussion in a way to explain their result more in the
context to chronic pancreatitis, this makes the paper more conclusive. They can
show a direct effect of sulindac on fibrosis development and the general immune
response. The paper is well written and sounds fine.
The question are mainly answered by the authors, they can show an effect of
sulindac on the activation of stellate cells by the activation marker alpha SMA
which is one of the key mechanisms in fibrogenesis. The influence of sulindac on
the immune regulation could be shown by real-time PCR as well as in western
blot analysis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:The effect of sulindac, a non-steroidal anti-inflammatory drug, attenuates
inflammation and fibrosis in a mouse model of chronic pancreatitis
Version: 5Date:17 July 2012
Reviewer: Matthias Sendler
Reviewer's report:
The authors change the discussion in a way to explain their result more in the
context to chronic pancreatitis, this makes the paper more conclusive. They can
show a direct effect of sulindac on fibrosis development and the general immune
response. The paper is well written and sounds fine.
The question are mainly answered by the authors, they can show an effect of
sulindac on the activation of stellate cells by the activation marker alpha SMA
which is one of the key mechanisms in fibrogenesis. The influence of sulindac on
the immune regulation could be shown by real-time PCR as well as in western
blot analysis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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