Title: Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver
failure in patients listed for liver transplantation
Version: 2 Date: 18 Apr 2021
Reviewer's report:
Well, there are several issues, which could be addressed to improve the manuscript:
1. Lactate as a predictor is already described several times:
a. Bernal et al 2002 (The Lancet) and 2010 (J Hepatol 2010)
b. McQuillan et al. Liver Transpl 2005
c.Hadem et al. Clin Gastroenterol Hepatol 2008
The cut-off value for creatinine is fixed at 87.52 µmol/l. This is the normal value for creatinine.
How can this be predictive? Concern lactate level is given in table 1 with ng/dl. I never
recognized this kind of value, I know mg/dl or mmol/l. PLease correct it.
An increased lactate level together with poor kidney function in ALF is always a predictor for
worse outcome. The question is. can you speculate from your data, for which patients was the
transplant futile?? That is important.
Title: Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver
failure in patients listed for liver transplantation
Version: 2 Date: 18 Apr 2021
Reviewer's report:
Well, there are several issues, which could be addressed to improve the manuscript:
1. Lactate as a predictor is already described several times:
a. Bernal et al 2002 (The Lancet) and 2010 (J Hepatol 2010)
b. McQuillan et al. Liver Transpl 2005
c.Hadem et al. Clin Gastroenterol Hepatol 2008
The cut-off value for creatinine is fixed at 87.52 µmol/l. This is the normal value for creatinine.
How can this be predictive? Concern lactate level is given in table 1 with ng/dl. I never
recognized this kind of value, I know mg/dl or mmol/l. PLease correct it.
An increased lactate level together with poor kidney function in ALF is always a predictor for
worse outcome. The question is. can you speculate from your data, for which patients was the
transplant futile?? That is important.
Please review this paper.
user
Title: Creatinine-lactate score predicts mortality in non-acetaminophen-induced acute liver
failure in patients listed for liver transplantation
Version: 2 Date: 18 Apr 2021
Reviewer's report:
Well, there are several issues, which could be addressed to improve the manuscript:
1. Lactate as a predictor is already described several times:
a. Bernal et al 2002 (The Lancet) and 2010 (J Hepatol 2010)
b. McQuillan et al. Liver Transpl 2005
c.Hadem et al. Clin Gastroenterol Hepatol 2008
The cut-off value for creatinine is fixed at 87.52 µmol/l. This is the normal value for creatinine.
How can this be predictive? Concern lactate level is given in table 1 with ng/dl. I never
recognized this kind of value, I know mg/dl or mmol/l. PLease correct it.
An increased lactate level together with poor kidney function in ALF is always a predictor for
worse outcome. The question is. can you speculate from your data, for which patients was the
transplant futile?? That is important.
assistant