Title: Global and Regional Burden of Pancreatitis: Epidemiological Trends, Risk Factors, and
Projections to 2050 from the Global Burden of Disease Study 2021
Version: 1 Date: 01 Oct 2024
Reviewer:  Amira A A Othman
Reviewer's report:
First of all
I want to congratulate the authors on their work. In this study, Li et al used data from the
Global Burden of Disease (GBD) Study 2021, globally, to assess the epidemiological trends of
pancreatitis from 1990 to 2021 and project future trends to 2050 providing a scientific basis for
enhancing pancreatitis prevention and control measures worldwide.
Pancreatitis, inflammation of the pancreas, is a major cause of morbidity and mortality with a
high global health impact. The most frequent gastrointestinal reason for hospital admission in
the US is acute pancreatitis. Even though it is less common, chronic pancreatitis severely lowers
a patient's quality of life*.
(*: doi.org/10.1016/j.pmedr.2024.102722).
The authors tried to contribute to this field of research with new findings, nevertheless, there is
an observation for which sufficient justification must be obtained.
In General:
1. Please improve the language.
In Title:
2. The authors may consider indicating the locality at which the study is directed.
In Abstract section
3. Make the abstract more concise.
4. The type of the study is to be mentioned. Is it a systematic analysis study?
5. More data about the enrolled patients are to be mentioned (ex. Age, sex, etc.).
6. It would help if you described the aim of your statistical analysis.
For example, Data on pancreatitis in older adults, including mortality and disability-adjusted
life years (DALYs) rates, were collected from the Global Burden of Disease (GBD) 2019 study.
Temporal trends were measured using joinpoint analyses and predicted using a Bayesian age-
period-cohort model. Additionally, the unequal distribution of the burden of pancreatitis in older
adults was quantified.
7. Isn't it required that the abstract conclusion focus on how to reduce the spread of this disease
based on the results of the study?
In the Introduction section:
8. Try to provide a summarized description of the Global Burden of Disease Study (GBD).
You may use the following
“The Global Burden of Disease Study (GBD) (https://www.healthdata.org/research-analysis/
gbd), The estimates are also available through an online tool and data files, for which registration
is required. GBD 2021 was published in The Lancet from February to May 2024, the survey
was performed by Over 12,000 researchers from over 160 countries, throughout 204 countries,
to apply a comprehensive regional and global research program on disease burden that assesses
mortality and disability from major diseases, injuries, and risk factors. The Global Burden of
Disease (GBD) 2019 study included 369 diseases and injuries in different regions, countries and
territories worldwide, which provides an opportunity to perform comprehensive assessments of
the epidemiological characteristics of various diseases”.
9. To the best of our knowledge, this is the first study to utilize the updated GBD 2021 data
for a comprehensive epidemiological analysis of pancreatitis. Please explain this sentence in the
notion of doi.org/10.1016/j.pmedr.2024.102722, and doi.org/10.3389/fpubh.2023.1118888 .
In the Methods section:
10. The GBD 2021 overview shall be transferred to the introduction section.
11. What is meant by DALYs? Define the abbreviation: deaths and disability-adjusted life years
12. Statistical analysis must be summarized.
In the Results section:
13. In Tables 1, 2, and 3: data are overcrowded, and could not be reviewed.
In the Discussion section:
14. The discussion section is one of the final parts of a research paper, in which an author
describes, analyzes, and interprets their findings. They explain the significance of those results
and tie everything back to the research question(s). In this manuscript, there is confusion between
what should be written in the introduction section, the result section, and the discussion section.
Please reconstruct the discussion section.
15. What are the study limitations?
16. What is the novelty of your study regarding the recent papers that studied the
pancreatitis epidemiological trends as A systematic analysis for the global burden of disease
study 2019? (doi.org/10.1016/j.pmedr.2024.102722, doi.org/10.3389/fpubh.2023.1118888 ,
and doi.org/10.1186/s12876-021-01906-2).
In the conclusion section:
17. The conclusion should restate your main points and provide closure.
Title: Global and Regional Burden of Pancreatitis: Epidemiological Trends, Risk Factors, and
Projections to 2050 from the Global Burden of Disease Study 2021
Version: 1 Date: 01 Oct 2024
Reviewer:  Amira A A Othman
Reviewer's report:
First of all
I want to congratulate the authors on their work. In this study, Li et al used data from the
Global Burden of Disease (GBD) Study 2021, globally, to assess the epidemiological trends of
pancreatitis from 1990 to 2021 and project future trends to 2050 providing a scientific basis for
enhancing pancreatitis prevention and control measures worldwide.
Pancreatitis, inflammation of the pancreas, is a major cause of morbidity and mortality with a
high global health impact. The most frequent gastrointestinal reason for hospital admission in
the US is acute pancreatitis. Even though it is less common, chronic pancreatitis severely lowers
a patient's quality of life*.
(*: doi.org/10.1016/j.pmedr.2024.102722).
The authors tried to contribute to this field of research with new findings, nevertheless, there is
an observation for which sufficient justification must be obtained.
In General:
1. Please improve the language.
In Title:
2. The authors may consider indicating the locality at which the study is directed.
In Abstract section
3. Make the abstract more concise.
4. The type of the study is to be mentioned. Is it a systematic analysis study?
5. More data about the enrolled patients are to be mentioned (ex. Age, sex, etc.).
6. It would help if you described the aim of your statistical analysis.
For example, Data on pancreatitis in older adults, including mortality and disability-adjusted
life years (DALYs) rates, were collected from the Global Burden of Disease (GBD) 2019 study.
Temporal trends were measured using joinpoint analyses and predicted using a Bayesian age-
period-cohort model. Additionally, the unequal distribution of the burden of pancreatitis in older
adults was quantified.
7. Isn't it required that the abstract conclusion focus on how to reduce the spread of this disease
based on the results of the study?
In the Introduction section:
8. Try to provide a summarized description of the Global Burden of Disease Study (GBD).
You may use the following
“The Global Burden of Disease Study (GBD) (https://www.healthdata.org/research-analysis/
gbd), The estimates are also available through an online tool and data files, for which registration
is required. GBD 2021 was published in The Lancet from February to May 2024, the survey
was performed by Over 12,000 researchers from over 160 countries, throughout 204 countries,
to apply a comprehensive regional and global research program on disease burden that assesses
mortality and disability from major diseases, injuries, and risk factors. The Global Burden of
Disease (GBD) 2019 study included 369 diseases and injuries in different regions, countries and
territories worldwide, which provides an opportunity to perform comprehensive assessments of
the epidemiological characteristics of various diseases”.
9. To the best of our knowledge, this is the first study to utilize the updated GBD 2021 data
for a comprehensive epidemiological analysis of pancreatitis. Please explain this sentence in the
notion of doi.org/10.1016/j.pmedr.2024.102722, and doi.org/10.3389/fpubh.2023.1118888 .
In the Methods section:
10. The GBD 2021 overview shall be transferred to the introduction section.
11. What is meant by DALYs? Define the abbreviation: deaths and disability-adjusted life years
12. Statistical analysis must be summarized.
In the Results section:
13. In Tables 1, 2, and 3: data are overcrowded, and could not be reviewed.
In the Discussion section:
14. The discussion section is one of the final parts of a research paper, in which an author
describes, analyzes, and interprets their findings. They explain the significance of those results
and tie everything back to the research question(s). In this manuscript, there is confusion between
what should be written in the introduction section, the result section, and the discussion section.
Please reconstruct the discussion section.
15. What are the study limitations?
16. What is the novelty of your study regarding the recent papers that studied the
pancreatitis epidemiological trends as A systematic analysis for the global burden of disease
study 2019? (doi.org/10.1016/j.pmedr.2024.102722, doi.org/10.3389/fpubh.2023.1118888 ,
and doi.org/10.1186/s12876-021-01906-2).
In the conclusion section:
17. The conclusion should restate your main points and provide closure.
Please review this paper.
user
Title: Global and Regional Burden of Pancreatitis: Epidemiological Trends, Risk Factors, and
Projections to 2050 from the Global Burden of Disease Study 2021
Version: 1 Date: 01 Oct 2024
Reviewer:  Amira A A Othman
Reviewer's report:
First of all
I want to congratulate the authors on their work. In this study, Li et al used data from the
Global Burden of Disease (GBD) Study 2021, globally, to assess the epidemiological trends of
pancreatitis from 1990 to 2021 and project future trends to 2050 providing a scientific basis for
enhancing pancreatitis prevention and control measures worldwide.
Pancreatitis, inflammation of the pancreas, is a major cause of morbidity and mortality with a
high global health impact. The most frequent gastrointestinal reason for hospital admission in
the US is acute pancreatitis. Even though it is less common, chronic pancreatitis severely lowers
a patient's quality of life*.
(*: doi.org/10.1016/j.pmedr.2024.102722).
The authors tried to contribute to this field of research with new findings, nevertheless, there is
an observation for which sufficient justification must be obtained.
In General:
1. Please improve the language.
In Title:
2. The authors may consider indicating the locality at which the study is directed.
In Abstract section
3. Make the abstract more concise.
4. The type of the study is to be mentioned. Is it a systematic analysis study?
5. More data about the enrolled patients are to be mentioned (ex. Age, sex, etc.).
6. It would help if you described the aim of your statistical analysis.
For example, Data on pancreatitis in older adults, including mortality and disability-adjusted
life years (DALYs) rates, were collected from the Global Burden of Disease (GBD) 2019 study.
Temporal trends were measured using joinpoint analyses and predicted using a Bayesian age-
period-cohort model. Additionally, the unequal distribution of the burden of pancreatitis in older
adults was quantified.
7. Isn't it required that the abstract conclusion focus on how to reduce the spread of this disease
based on the results of the study?
In the Introduction section:
8. Try to provide a summarized description of the Global Burden of Disease Study (GBD).
You may use the following
“The Global Burden of Disease Study (GBD) (https://www.healthdata.org/research-analysis/
gbd), The estimates are also available through an online tool and data files, for which registration
is required. GBD 2021 was published in The Lancet from February to May 2024, the survey
was performed by Over 12,000 researchers from over 160 countries, throughout 204 countries,
to apply a comprehensive regional and global research program on disease burden that assesses
mortality and disability from major diseases, injuries, and risk factors. The Global Burden of
Disease (GBD) 2019 study included 369 diseases and injuries in different regions, countries and
territories worldwide, which provides an opportunity to perform comprehensive assessments of
the epidemiological characteristics of various diseases”.
9. To the best of our knowledge, this is the first study to utilize the updated GBD 2021 data
for a comprehensive epidemiological analysis of pancreatitis. Please explain this sentence in the
notion of doi.org/10.1016/j.pmedr.2024.102722, and doi.org/10.3389/fpubh.2023.1118888 .
In the Methods section:
10. The GBD 2021 overview shall be transferred to the introduction section.
11. What is meant by DALYs? Define the abbreviation: deaths and disability-adjusted life years
12. Statistical analysis must be summarized.
In the Results section:
13. In Tables 1, 2, and 3: data are overcrowded, and could not be reviewed.
In the Discussion section:
14. The discussion section is one of the final parts of a research paper, in which an author
describes, analyzes, and interprets their findings. They explain the significance of those results
and tie everything back to the research question(s). In this manuscript, there is confusion between
what should be written in the introduction section, the result section, and the discussion section.
Please reconstruct the discussion section.
15. What are the study limitations?
16. What is the novelty of your study regarding the recent papers that studied the
pancreatitis epidemiological trends as A systematic analysis for the global burden of disease
study 2019? (doi.org/10.1016/j.pmedr.2024.102722, doi.org/10.3389/fpubh.2023.1118888 ,
and doi.org/10.1186/s12876-021-01906-2).
In the conclusion section:
17. The conclusion should restate your main points and provide closure.
assistant