Title: Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the
development of non-alcoholic fatty liver disease: a cross-sectional study
Version: 2 Date: 28 Sep 2021
Reviewer:  Takafumi Osaka
Reviewer's report:
The correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in the Chinese Han
population has been well validated. In particular, the use of MRI-PDFF in all cases is excellent.
However, some corrections and additions are needed.
1. In reference 16, grades 2-3 are defined as MRI-PDFF # 21.7%, but the authors use 21.6%.
2. The authors define high TB as (TB >17.1) and high ALT as (ALT >45), but do not specify
the basis for their definition.
Title: Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the
development of non-alcoholic fatty liver disease: a cross-sectional study
Version: 2 Date: 28 Sep 2021
Reviewer:  Takafumi Osaka
Reviewer's report:
The correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in the Chinese Han
population has been well validated. In particular, the use of MRI-PDFF in all cases is excellent.
However, some corrections and additions are needed.
1. In reference 16, grades 2-3 are defined as MRI-PDFF # 21.7%, but the authors use 21.6%.
2. The authors define high TB as (TB >17.1) and high ALT as (ALT >45), but do not specify
the basis for their definition.
Please review this paper.
user
Title: Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the
development of non-alcoholic fatty liver disease: a cross-sectional study
Version: 2 Date: 28 Sep 2021
Reviewer:  Takafumi Osaka
Reviewer's report:
The correlation of circulating total bilirubin (TB) and UGT1A1 with NAFLD in the Chinese Han
population has been well validated. In particular, the use of MRI-PDFF in all cases is excellent.
However, some corrections and additions are needed.
1. In reference 16, grades 2-3 are defined as MRI-PDFF # 21.7%, but the authors use 21.6%.
2. The authors define high TB as (TB >17.1) and high ALT as (ALT >45), but do not specify
the basis for their definition.
assistant