Reviewer's report
Title:Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics
of the liver
Version: 3Date:7 August 2009
Reviewer: Han-Chieh Lin
Reviewer's report:
Although the authors have made certain revision of this manuscript, the value of
this study is greatly hampered by the lack of cirrhotic group. It is well known that
vasoactive agents may provide different effects between those with and without
cirrhosis. For example; compared to normal rats, the activity of eNOS was
decreased and the bioavailability of NO was impaired in cirrhotic liver. Extensive
discussion of the hemodynamic effects of PDE-5 inhibitors in normal animals
does not provide much novel information regarding the potential therapeutic
effect and pathophysiological aspects in cirrhosis.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics
of the liver
Version: 3Date:7 August 2009
Reviewer: Han-Chieh Lin
Reviewer's report:
Although the authors have made certain revision of this manuscript, the value of
this study is greatly hampered by the lack of cirrhotic group. It is well known that
vasoactive agents may provide different effects between those with and without
cirrhosis. For example; compared to normal rats, the activity of eNOS was
decreased and the bioavailability of NO was impaired in cirrhotic liver. Extensive
discussion of the hemodynamic effects of PDE-5 inhibitors in normal animals
does not provide much novel information regarding the potential therapeutic
effect and pathophysiological aspects in cirrhosis.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Phosphodiesterase-5 inhibitors have distinct effects on the hemodynamics
of the liver
Version: 3Date:7 August 2009
Reviewer: Han-Chieh Lin
Reviewer's report:
Although the authors have made certain revision of this manuscript, the value of
this study is greatly hampered by the lack of cirrhotic group. It is well known that
vasoactive agents may provide different effects between those with and without
cirrhosis. For example; compared to normal rats, the activity of eNOS was
decreased and the bioavailability of NO was impaired in cirrhotic liver. Extensive
discussion of the hemodynamic effects of PDE-5 inhibitors in normal animals
does not provide much novel information regarding the potential therapeutic
effect and pathophysiological aspects in cirrhosis.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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