Title: The influences of timing of urgent endoscopy in patients with acute variceal bleeding:
A cohort study
Version: 1 Date: 28 Jul 2022
Reviewer's report:
the paper written by Xiaohan Yan et collegues is an interesting paper and well written with the
aim to examine the relation between the timing of endoscopy and the short-term outcomes of
patients with AVB.
The authors concluded  that endoscopy performed within 6 hours of admission, rather than within
6 to 24 hours, did not improve six-week clinical outcomes in patients in stable condition with
AVB and even those who were at high risk of further bleeding and death.
I have some suggestions, in particular:
1- it's not clear in the methods the presence of chirrosis and how this was detected
2- nothing was decleared about prhophylatic therapy for AVB in particular NBSS. How many
patients had this therapy before the bleeding episode? this is an important point in particular in
the multivariate analysis
3-  are there any informatons about fiboscan value? as well know the BAVENO 7 criteria
are usful to identify patients that have to attend endoscopy; the fibroscan value in KPa is an
important information needed, and  usful in multivariate.
4 - Kaplan mayer and cox regression are necessary to identify the 6 weeks mortality
Title: The influences of timing of urgent endoscopy in patients with acute variceal bleeding:
A cohort study
Version: 1 Date: 28 Jul 2022
Reviewer's report:
the paper written by Xiaohan Yan et collegues is an interesting paper and well written with the
aim to examine the relation between the timing of endoscopy and the short-term outcomes of
patients with AVB.
The authors concluded  that endoscopy performed within 6 hours of admission, rather than within
6 to 24 hours, did not improve six-week clinical outcomes in patients in stable condition with
AVB and even those who were at high risk of further bleeding and death.
I have some suggestions, in particular:
1- it's not clear in the methods the presence of chirrosis and how this was detected
2- nothing was decleared about prhophylatic therapy for AVB in particular NBSS. How many
patients had this therapy before the bleeding episode? this is an important point in particular in
the multivariate analysis
3-  are there any informatons about fiboscan value? as well know the BAVENO 7 criteria
are usful to identify patients that have to attend endoscopy; the fibroscan value in KPa is an
important information needed, and  usful in multivariate.
4 - Kaplan mayer and cox regression are necessary to identify the 6 weeks mortality
Please review this paper.
user
Title: The influences of timing of urgent endoscopy in patients with acute variceal bleeding:
A cohort study
Version: 1 Date: 28 Jul 2022
Reviewer's report:
the paper written by Xiaohan Yan et collegues is an interesting paper and well written with the
aim to examine the relation between the timing of endoscopy and the short-term outcomes of
patients with AVB.
The authors concluded  that endoscopy performed within 6 hours of admission, rather than within
6 to 24 hours, did not improve six-week clinical outcomes in patients in stable condition with
AVB and even those who were at high risk of further bleeding and death.
I have some suggestions, in particular:
1- it's not clear in the methods the presence of chirrosis and how this was detected
2- nothing was decleared about prhophylatic therapy for AVB in particular NBSS. How many
patients had this therapy before the bleeding episode? this is an important point in particular in
the multivariate analysis
3-  are there any informatons about fiboscan value? as well know the BAVENO 7 criteria
are usful to identify patients that have to attend endoscopy; the fibroscan value in KPa is an
important information needed, and  usful in multivariate.
4 - Kaplan mayer and cox regression are necessary to identify the 6 weeks mortality
assistant