Reviewer ’s report  
 
Title: A case report of prostate cancer metastases to the stomach resembling undifferentiated -
type early gastric cancer  
 
Version: 0 Date: 19 May 2017  
 
Reviewer: Yeong Yeh Lee  
 
Reviewer's report:  
 
This is a rare case of prostate metastasis to the stomach and there are only a handful of case 
reports. The presentation is atypical because endoscopic appearance in addition to negative PSA 
stain but positive for PSAP and this is postulated by authors bec ause of hormonal treatment. 
Further comments as below:  
1. Was there imaging of abdomen e.g. CT scan performed to stage the lesion  
 
2. Can please clarify the extent or depth of resected lesion especially when author mentioned 
'predominantly' in the superfici al layer  
 
3. If PSAP was positive from endoscopic biopsy, what would the next plan of management? 
And what would the author do now that the lesion has been endoscopically resected?  
 
4. Authors should review other existing case reports of prostatic metastasis  to stomach and how 
their presentation differ  
 
5. Conclusion needs to revise - it is 'almost indistinguishable' or just 'indistinguishable'  
 
6. It is likely that many of early prostate metastasis may have endoscopic appearance similar to 
EGC but they are not  picked up readily without enhanced imaging. What are authors' 
thoughts on this.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary control s? 
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any  statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not rel evant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an o rganisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reim bursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relat ion to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review po licy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
respons es. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confid ential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: A case report of prostate cancer metastases to the stomach resembling undifferentiated -
type early gastric cancer  
 
Version: 0 Date: 19 May 2017  
 
Reviewer: Yeong Yeh Lee  
 
Reviewer's report:  
 
This is a rare case of prostate metastasis to the stomach and there are only a handful of case 
reports. The presentation is atypical because endoscopic appearance in addition to negative PSA 
stain but positive for PSAP and this is postulated by authors bec ause of hormonal treatment. 
Further comments as below:  
1. Was there imaging of abdomen e.g. CT scan performed to stage the lesion  
 
2. Can please clarify the extent or depth of resected lesion especially when author mentioned 
'predominantly' in the superfici al layer  
 
3. If PSAP was positive from endoscopic biopsy, what would the next plan of management? 
And what would the author do now that the lesion has been endoscopically resected?  
 
4. Authors should review other existing case reports of prostatic metastasis  to stomach and how 
their presentation differ  
 
5. Conclusion needs to revise - it is 'almost indistinguishable' or just 'indistinguishable'  
 
6. It is likely that many of early prostate metastasis may have endoscopic appearance similar to 
EGC but they are not  picked up readily without enhanced imaging. What are authors' 
thoughts on this.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary control s? 
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any  statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not rel evant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an o rganisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reim bursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relat ion to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review po licy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
respons es. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confid ential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: A case report of prostate cancer metastases to the stomach resembling undifferentiated -
type early gastric cancer  
 
Version: 0 Date: 19 May 2017  
 
Reviewer: Yeong Yeh Lee  
 
Reviewer's report:  
 
This is a rare case of prostate metastasis to the stomach and there are only a handful of case 
reports. The presentation is atypical because endoscopic appearance in addition to negative PSA 
stain but positive for PSAP and this is postulated by authors bec ause of hormonal treatment. 
Further comments as below:  
1. Was there imaging of abdomen e.g. CT scan performed to stage the lesion  
 
2. Can please clarify the extent or depth of resected lesion especially when author mentioned 
'predominantly' in the superfici al layer  
 
3. If PSAP was positive from endoscopic biopsy, what would the next plan of management? 
And what would the author do now that the lesion has been endoscopically resected?  
 
4. Authors should review other existing case reports of prostatic metastasis  to stomach and how 
their presentation differ  
 
5. Conclusion needs to revise - it is 'almost indistinguishable' or just 'indistinguishable'  
 
6. It is likely that many of early prostate metastasis may have endoscopic appearance similar to 
EGC but they are not  picked up readily without enhanced imaging. What are authors' 
thoughts on this.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary control s? 
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any  statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not rel evant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an o rganisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reim bursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relat ion to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review po licy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
respons es. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confid ential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant