Title: Association between circadian syndrome and gallstones: a cross-sectional study of
NHANES 2017–2020
Version: 3 Date: 07 Sep 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Authors tried a leap of logic connecting  cicardian syndrome and gallstone formation
Since metabolic syndrome and gallstone formation are strongly connected it is expected
that at least 5 parameters of cicardian syndrome are connected with gallstone formation
(minimum requirement for cicardian syndrome diagnosis) Short sleep and depression have been
biographically connected tp gallstone formation Authors should provide data especially for those
two factors that make the difference From the first table it seems that at least short sleep is not
connected to gallstone formation Univariated and multivariated analysis results should be clearly
presented Other ways connecting cicardian rythm to  gallstone formation would be useful, like
number of meals (a parameter that has been connected to gallstone formation), diulnar rythm
of living (people working during  daytime vs those working night shifts) Finaly authors should
exlain some descrepancies to what is known for intance high frequency of gallstone disease
among Hispanics a parameter not verified by their data or peak of gallstone disease in 35-49 age
age group, while literature supports high gallstone prevalence in higher ages Actually the first
table is supportive to medical literature rather than what appears in the text
Title: Association between circadian syndrome and gallstones: a cross-sectional study of
NHANES 2017–2020
Version: 3 Date: 07 Sep 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Authors tried a leap of logic connecting  cicardian syndrome and gallstone formation
Since metabolic syndrome and gallstone formation are strongly connected it is expected
that at least 5 parameters of cicardian syndrome are connected with gallstone formation
(minimum requirement for cicardian syndrome diagnosis) Short sleep and depression have been
biographically connected tp gallstone formation Authors should provide data especially for those
two factors that make the difference From the first table it seems that at least short sleep is not
connected to gallstone formation Univariated and multivariated analysis results should be clearly
presented Other ways connecting cicardian rythm to  gallstone formation would be useful, like
number of meals (a parameter that has been connected to gallstone formation), diulnar rythm
of living (people working during  daytime vs those working night shifts) Finaly authors should
exlain some descrepancies to what is known for intance high frequency of gallstone disease
among Hispanics a parameter not verified by their data or peak of gallstone disease in 35-49 age
age group, while literature supports high gallstone prevalence in higher ages Actually the first
table is supportive to medical literature rather than what appears in the text
Please review this paper.
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Title: Association between circadian syndrome and gallstones: a cross-sectional study of
NHANES 2017–2020
Version: 3 Date: 07 Sep 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Authors tried a leap of logic connecting  cicardian syndrome and gallstone formation
Since metabolic syndrome and gallstone formation are strongly connected it is expected
that at least 5 parameters of cicardian syndrome are connected with gallstone formation
(minimum requirement for cicardian syndrome diagnosis) Short sleep and depression have been
biographically connected tp gallstone formation Authors should provide data especially for those
two factors that make the difference From the first table it seems that at least short sleep is not
connected to gallstone formation Univariated and multivariated analysis results should be clearly
presented Other ways connecting cicardian rythm to  gallstone formation would be useful, like
number of meals (a parameter that has been connected to gallstone formation), diulnar rythm
of living (people working during  daytime vs those working night shifts) Finaly authors should
exlain some descrepancies to what is known for intance high frequency of gallstone disease
among Hispanics a parameter not verified by their data or peak of gallstone disease in 35-49 age
age group, while literature supports high gallstone prevalence in higher ages Actually the first
table is supportive to medical literature rather than what appears in the text
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