Reviewer ’s report  
 
Title: Case Report of Cryptogenic Multifocal Ulcerous Sten osing Enteritis (CMUSE): A Rare 
Disease May Contribute to Endoscopy -Capsule Retention in the Sm all Intestine  
 
Version: 0 Date: 25 Jan 2019  
 
Reviewer: Hsu-Heng Yen  
 
Reviewer's report:  
 
#1. Page 5 Line 88 , 92 -93. The author mention " Although different names remained, they 
represent the same disease entity  "  
 
Although CNSU and  CMUSE are consider idiopathic previously, CMUSE from chronic 
nonspecific multiple ulcers  of the small intestine (CNSU) are now considered different entity not 
same entity. CNSU is associated with loss -of-function mutations in the SLCO2A1 gene and now 
established  as a  new disease entity called  "chronic enteropathy associated with SLCO2A1 
gene" (CEAS). ( Umeno et al  World J   
 
Gastroenterol. 2018 Jul 28;       24(28) ). CMUSE was found to be  an autosomal recessive 
inherited diseas e caused by mutations in the PLA2G4A gene . I didn't agree CNSU and CMUSE 
is different names of same disease entity.  
 
 
#2. Page 7, Line 128 -129. The authors mention " the most effective is immunotherapy and 
surgery "  
 
As CMUSE is an idiopathic disease, steroids are typically used. Please provide reference for use 
of "immunotherapy" in CMUSE.  
 
 
#3. Page 3, Line 61 -63.  
Please provide reference range for the laboratory data.  
 
 
#4. Page 4, Line 66 -67. The authors mention CT showed no stenosis. figure 1, the authors 
mentioned "The findings show segmental bowel walls are thickened with suspicious strictures 
(arrows) ". Is there stenosis or not ? , if stenosis is present, wh y choose capsule endoscopy ?  
 
 
 
 
 
 
 
Are the methods  appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in a ny way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or  in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the  content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interest s' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
Reviewer ’s report  
 
Title: Case Report of Cryptogenic Multifocal Ulcerous Sten osing Enteritis (CMUSE): A Rare 
Disease May Contribute to Endoscopy -Capsule Retention in the Sm all Intestine  
 
Version: 0 Date: 25 Jan 2019  
 
Reviewer: Hsu-Heng Yen  
 
Reviewer's report:  
 
#1. Page 5 Line 88 , 92 -93. The author mention " Although different names remained, they 
represent the same disease entity  "  
 
Although CNSU and  CMUSE are consider idiopathic previously, CMUSE from chronic 
nonspecific multiple ulcers  of the small intestine (CNSU) are now considered different entity not 
same entity. CNSU is associated with loss -of-function mutations in the SLCO2A1 gene and now 
established  as a  new disease entity called  "chronic enteropathy associated with SLCO2A1 
gene" (CEAS). ( Umeno et al  World J   
 
Gastroenterol. 2018 Jul 28;       24(28) ). CMUSE was found to be  an autosomal recessive 
inherited diseas e caused by mutations in the PLA2G4A gene . I didn't agree CNSU and CMUSE 
is different names of same disease entity.  
 
 
#2. Page 7, Line 128 -129. The authors mention " the most effective is immunotherapy and 
surgery "  
 
As CMUSE is an idiopathic disease, steroids are typically used. Please provide reference for use 
of "immunotherapy" in CMUSE.  
 
 
#3. Page 3, Line 61 -63.  
Please provide reference range for the laboratory data.  
 
 
#4. Page 4, Line 66 -67. The authors mention CT showed no stenosis. figure 1, the authors 
mentioned "The findings show segmental bowel walls are thickened with suspicious strictures 
(arrows) ". Is there stenosis or not ? , if stenosis is present, wh y choose capsule endoscopy ?  
 
 
 
 
 
 
 
Are the methods  appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in a ny way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or  in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the  content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interest s' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
Please review this paper.
user
Reviewer ’s report  
 
Title: Case Report of Cryptogenic Multifocal Ulcerous Sten osing Enteritis (CMUSE): A Rare 
Disease May Contribute to Endoscopy -Capsule Retention in the Sm all Intestine  
 
Version: 0 Date: 25 Jan 2019  
 
Reviewer: Hsu-Heng Yen  
 
Reviewer's report:  
 
#1. Page 5 Line 88 , 92 -93. The author mention " Although different names remained, they 
represent the same disease entity  "  
 
Although CNSU and  CMUSE are consider idiopathic previously, CMUSE from chronic 
nonspecific multiple ulcers  of the small intestine (CNSU) are now considered different entity not 
same entity. CNSU is associated with loss -of-function mutations in the SLCO2A1 gene and now 
established  as a  new disease entity called  "chronic enteropathy associated with SLCO2A1 
gene" (CEAS). ( Umeno et al  World J   
 
Gastroenterol. 2018 Jul 28;       24(28) ). CMUSE was found to be  an autosomal recessive 
inherited diseas e caused by mutations in the PLA2G4A gene . I didn't agree CNSU and CMUSE 
is different names of same disease entity.  
 
 
#2. Page 7, Line 128 -129. The authors mention " the most effective is immunotherapy and 
surgery "  
 
As CMUSE is an idiopathic disease, steroids are typically used. Please provide reference for use 
of "immunotherapy" in CMUSE.  
 
 
#3. Page 3, Line 61 -63.  
Please provide reference range for the laboratory data.  
 
 
#4. Page 4, Line 66 -67. The authors mention CT showed no stenosis. figure 1, the authors 
mentioned "The findings show segmental bowel walls are thickened with suspicious strictures 
(arrows) ". Is there stenosis or not ? , if stenosis is present, wh y choose capsule endoscopy ?  
 
 
 
 
 
 
 
Are the methods  appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in a ny way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or  in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the  content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interest s' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscr ipt is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://crea tivecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the jour nal 
assistant