Title: CDX2 and Reg IV expression and correlation in gastric cancer
Version: 2 Date: 07 Nov 2020
Reviewer:  Fan-biao Kong
Reviewer's report:
1. it's better to prove that Reg IV promote cell migration and invation.
2. it would be easier to be accepted if you specify the relationship between CDX2 and Reg IV.
does CDX2 directly affect Reg IV, or there is other gene in the pathway between CDX2 and
Reg IV?
3. in the Method part, you designed Chemically synthetic siRNAs for human CDX2, Reg IV.
but in the Results, you presented CDX2 overexpressed and downregulated respectively. did you
silencing CDX2 and Reg IV in the same time? or by several times?
Title: CDX2 and Reg IV expression and correlation in gastric cancer
Version: 2 Date: 07 Nov 2020
Reviewer:  Fan-biao Kong
Reviewer's report:
1. it's better to prove that Reg IV promote cell migration and invation.
2. it would be easier to be accepted if you specify the relationship between CDX2 and Reg IV.
does CDX2 directly affect Reg IV, or there is other gene in the pathway between CDX2 and
Reg IV?
3. in the Method part, you designed Chemically synthetic siRNAs for human CDX2, Reg IV.
but in the Results, you presented CDX2 overexpressed and downregulated respectively. did you
silencing CDX2 and Reg IV in the same time? or by several times?
Please review this paper.
user
Title: CDX2 and Reg IV expression and correlation in gastric cancer
Version: 2 Date: 07 Nov 2020
Reviewer:  Fan-biao Kong
Reviewer's report:
1. it's better to prove that Reg IV promote cell migration and invation.
2. it would be easier to be accepted if you specify the relationship between CDX2 and Reg IV.
does CDX2 directly affect Reg IV, or there is other gene in the pathway between CDX2 and
Reg IV?
3. in the Method part, you designed Chemically synthetic siRNAs for human CDX2, Reg IV.
but in the Results, you presented CDX2 overexpressed and downregulated respectively. did you
silencing CDX2 and Reg IV in the same time? or by several times?
assistant