Reviewer's report 
 Factors associated with disease evolution in Greek patients with inflammatory bowel disease. Title: 
 2  6 June 2006 Version: Date: 
 Peter Laszlo Lakatos Reviewer: 
Reviewer's report: 
The revised manuscript was significantly improved, results are much better focusing on important findings. 
Patient selection and re-assessment was also discussed more detailed. 
Compulsory Comments; 
1. Probability of proximal extension in proctitis were noted in 11/62 patients and change in behavior in 3/15 
CD from B2 to B3 altogether, however the â €˜suspected â €˜ low patients numbers after 10 and 20-year 
disease (no data are available on these data in the manuscript) duration led to the relatively high probability 
of changing the extension and behavior, thus these results should be interpreted more cautiously in the 
discussion. 
2. It is compulsory to add A; patient numbers should be included to Figures 1-3 at 5-, 10-, 15 and 20 years 
after IBD diagnosis and B; the Y-axis should be renamed as â €œProbability of change in disease 
behaviourâ €, â €œProbability to avoid surgeryâ € and â €œProbability of change in disease extentâ € 
also the X axis to â €œYears from IBD diagnosisâ €. This can be done if authors use the figures as picture 
format (e.g. jpeg). 
Minor essential revisions; 
1. Table 1. showing Vienna classification should be omitted 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research interests Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Reviewer's report 
 Factors associated with disease evolution in Greek patients with inflammatory bowel disease. Title: 
 2  6 June 2006 Version: Date: 
 Peter Laszlo Lakatos Reviewer: 
Reviewer's report: 
The revised manuscript was significantly improved, results are much better focusing on important findings. 
Patient selection and re-assessment was also discussed more detailed. 
Compulsory Comments; 
1. Probability of proximal extension in proctitis were noted in 11/62 patients and change in behavior in 3/15 
CD from B2 to B3 altogether, however the â €˜suspected â €˜ low patients numbers after 10 and 20-year 
disease (no data are available on these data in the manuscript) duration led to the relatively high probability 
of changing the extension and behavior, thus these results should be interpreted more cautiously in the 
discussion. 
2. It is compulsory to add A; patient numbers should be included to Figures 1-3 at 5-, 10-, 15 and 20 years 
after IBD diagnosis and B; the Y-axis should be renamed as â €œProbability of change in disease 
behaviourâ €, â €œProbability to avoid surgeryâ € and â €œProbability of change in disease extentâ € 
also the X axis to â €œYears from IBD diagnosisâ €. This can be done if authors use the figures as picture 
format (e.g. jpeg). 
Minor essential revisions; 
1. Table 1. showing Vienna classification should be omitted 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research interests Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Please review this paper.
user
Reviewer's report 
 Factors associated with disease evolution in Greek patients with inflammatory bowel disease. Title: 
 2  6 June 2006 Version: Date: 
 Peter Laszlo Lakatos Reviewer: 
Reviewer's report: 
The revised manuscript was significantly improved, results are much better focusing on important findings. 
Patient selection and re-assessment was also discussed more detailed. 
Compulsory Comments; 
1. Probability of proximal extension in proctitis were noted in 11/62 patients and change in behavior in 3/15 
CD from B2 to B3 altogether, however the â €˜suspected â €˜ low patients numbers after 10 and 20-year 
disease (no data are available on these data in the manuscript) duration led to the relatively high probability 
of changing the extension and behavior, thus these results should be interpreted more cautiously in the 
discussion. 
2. It is compulsory to add A; patient numbers should be included to Figures 1-3 at 5-, 10-, 15 and 20 years 
after IBD diagnosis and B; the Y-axis should be renamed as â €œProbability of change in disease 
behaviourâ €, â €œProbability to avoid surgeryâ € and â €œProbability of change in disease extentâ € 
also the X axis to â €œYears from IBD diagnosisâ €. This can be done if authors use the figures as picture 
format (e.g. jpeg). 
Minor essential revisions; 
1. Table 1. showing Vienna classification should be omitted 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research interests Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
assistant