Reviewer's report
Title:Validation of the Diffusion-weighted Imaging Method for Activity Evaluation
in Crohn's Disease Patients Underwent Magnetic Resonance Enterography
Version:2Date:2 September 2014
Reviewer: Aiping Mao
Reviewer's report:
The authors evaluate the clinical value of DWI and MRE in assessing active
inflammation in CD.As a non-invasive tool, MRE has been used to evaluate
Crohn’s Disease activity in many recent researchers. Most of them focus on
gadolinium-enhanced T1-weighted sequence. It is advanced and reasonable for
the authors to combined DWI with MRE to evaluate CD. But I still have some
question about the method as follows:
1. In the part of MRI evaluation, how to definite “DWI hyper-intensity”, please
illustrate it clearly.
2. In the part of “MRE combined with DWI improves the diagnostic accuracy for
active lesions?”, authors used three protocols. The Protocol A is” only DW
imaging were used”. I think it is hard to find out the inflammatory bowel segment
just use DWI. The authors should explain it.
3. In the part of “MRE combined with DWI improves the diagnostic accuracy for
active lesions?”, both protocol A and C used DWI. In these two protocols, Which
B value was used?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Reviewer's report
Title:Validation of the Diffusion-weighted Imaging Method for Activity Evaluation
in Crohn's Disease Patients Underwent Magnetic Resonance Enterography
Version:2Date:2 September 2014
Reviewer: Aiping Mao
Reviewer's report:
The authors evaluate the clinical value of DWI and MRE in assessing active
inflammation in CD.As a non-invasive tool, MRE has been used to evaluate
Crohn’s Disease activity in many recent researchers. Most of them focus on
gadolinium-enhanced T1-weighted sequence. It is advanced and reasonable for
the authors to combined DWI with MRE to evaluate CD. But I still have some
question about the method as follows:
1. In the part of MRI evaluation, how to definite “DWI hyper-intensity”, please
illustrate it clearly.
2. In the part of “MRE combined with DWI improves the diagnostic accuracy for
active lesions?”, authors used three protocols. The Protocol A is” only DW
imaging were used”. I think it is hard to find out the inflammatory bowel segment
just use DWI. The authors should explain it.
3. In the part of “MRE combined with DWI improves the diagnostic accuracy for
active lesions?”, both protocol A and C used DWI. In these two protocols, Which
B value was used?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Please review this paper.
user
Reviewer's report
Title:Validation of the Diffusion-weighted Imaging Method for Activity Evaluation
in Crohn's Disease Patients Underwent Magnetic Resonance Enterography
Version:2Date:2 September 2014
Reviewer: Aiping Mao
Reviewer's report:
The authors evaluate the clinical value of DWI and MRE in assessing active
inflammation in CD.As a non-invasive tool, MRE has been used to evaluate
Crohn’s Disease activity in many recent researchers. Most of them focus on
gadolinium-enhanced T1-weighted sequence. It is advanced and reasonable for
the authors to combined DWI with MRE to evaluate CD. But I still have some
question about the method as follows:
1. In the part of MRI evaluation, how to definite “DWI hyper-intensity”, please
illustrate it clearly.
2. In the part of “MRE combined with DWI improves the diagnostic accuracy for
active lesions?”, authors used three protocols. The Protocol A is” only DW
imaging were used”. I think it is hard to find out the inflammatory bowel segment
just use DWI. The authors should explain it.
3. In the part of “MRE combined with DWI improves the diagnostic accuracy for
active lesions?”, both protocol A and C used DWI. In these two protocols, Which
B value was used?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
assistant