Title: The prognostic nutritional index is an effective prognostic and nutritional status indicator
for cirrhosis
Version: 0 Date: 06 Nov 2024
Reviewer's report:
In this manuscript entitled “Prognostic nutritional index: a validated biomarker to predict
prognosis in cirrhotic patients”, the authors validated the ability of prognostic nutritional index
(PNI) in stratification of cirrhosis and mortality. While the association between nutritional status
and cirrhosis is important, there are some concerns which should be clarified.
Major comments
1. The new consensus of nutritional assessment is the Global Leadership Initiative on
Malnutrition criteria. The authors should modify the introduction using this study (PMID:
35861232).
2. The authors assessed mortality in this study. However, mortality should be analyzed using
the cox proportional hazards model.
3. In the statistical analysis section, details on how covariates were selected for logistic
regression are missing.
4. Some abbreviations, such as INR, CTP, MELD, and AUC in the abstract and CONUT, TG/
HDL-C, LDL-C, ApoA, ApoB, OR, and CI in the manuscript, appear without initial definitions,
which may be confusing for readers unfamiliar with these terms. Ensuring all abbreviations are
clearly defined at their first occurrence would improve clarity.
5. There are many typographical errors throughout the text, such as inconsistent spacing and
occasional grammatical mistakes throughout the paper. I would suggest using the language
editing service to improve the readability of the manuscript.
Minor comments
1. The authors must reconsider the title of the paper because the current title is very similar to
a previous report (PMID: 36687701).
2. Cirrhotic patients and alcoholic cirrhosis are inappropriate explanations. This should be
“patients with cirrhosis” and “alcohol-related/associated cirrhosis”.
Title: The prognostic nutritional index is an effective prognostic and nutritional status indicator
for cirrhosis
Version: 0 Date: 06 Nov 2024
Reviewer's report:
In this manuscript entitled “Prognostic nutritional index: a validated biomarker to predict
prognosis in cirrhotic patients”, the authors validated the ability of prognostic nutritional index
(PNI) in stratification of cirrhosis and mortality. While the association between nutritional status
and cirrhosis is important, there are some concerns which should be clarified.
Major comments
1. The new consensus of nutritional assessment is the Global Leadership Initiative on
Malnutrition criteria. The authors should modify the introduction using this study (PMID:
35861232).
2. The authors assessed mortality in this study. However, mortality should be analyzed using
the cox proportional hazards model.
3. In the statistical analysis section, details on how covariates were selected for logistic
regression are missing.
4. Some abbreviations, such as INR, CTP, MELD, and AUC in the abstract and CONUT, TG/
HDL-C, LDL-C, ApoA, ApoB, OR, and CI in the manuscript, appear without initial definitions,
which may be confusing for readers unfamiliar with these terms. Ensuring all abbreviations are
clearly defined at their first occurrence would improve clarity.
5. There are many typographical errors throughout the text, such as inconsistent spacing and
occasional grammatical mistakes throughout the paper. I would suggest using the language
editing service to improve the readability of the manuscript.
Minor comments
1. The authors must reconsider the title of the paper because the current title is very similar to
a previous report (PMID: 36687701).
2. Cirrhotic patients and alcoholic cirrhosis are inappropriate explanations. This should be
“patients with cirrhosis” and “alcohol-related/associated cirrhosis”.
Please review this paper.
user
Title: The prognostic nutritional index is an effective prognostic and nutritional status indicator
for cirrhosis
Version: 0 Date: 06 Nov 2024
Reviewer's report:
In this manuscript entitled “Prognostic nutritional index: a validated biomarker to predict
prognosis in cirrhotic patients”, the authors validated the ability of prognostic nutritional index
(PNI) in stratification of cirrhosis and mortality. While the association between nutritional status
and cirrhosis is important, there are some concerns which should be clarified.
Major comments
1. The new consensus of nutritional assessment is the Global Leadership Initiative on
Malnutrition criteria. The authors should modify the introduction using this study (PMID:
35861232).
2. The authors assessed mortality in this study. However, mortality should be analyzed using
the cox proportional hazards model.
3. In the statistical analysis section, details on how covariates were selected for logistic
regression are missing.
4. Some abbreviations, such as INR, CTP, MELD, and AUC in the abstract and CONUT, TG/
HDL-C, LDL-C, ApoA, ApoB, OR, and CI in the manuscript, appear without initial definitions,
which may be confusing for readers unfamiliar with these terms. Ensuring all abbreviations are
clearly defined at their first occurrence would improve clarity.
5. There are many typographical errors throughout the text, such as inconsistent spacing and
occasional grammatical mistakes throughout the paper. I would suggest using the language
editing service to improve the readability of the manuscript.
Minor comments
1. The authors must reconsider the title of the paper because the current title is very similar to
a previous report (PMID: 36687701).
2. Cirrhotic patients and alcoholic cirrhosis are inappropriate explanations. This should be
“patients with cirrhosis” and “alcohol-related/associated cirrhosis”.
assistant