Reviewer's report
Title:Goat milk with and without increased concentrations of lysozyme improves
repair of intestinal cells damage induced by enteroaggregative Escherichia coli
Version: 1Date:19 May 2012
Reviewer: Mona Bajaj-Elliott
Reviewer's report:
The paper is well written and clear in its findings. I have two comments that the
author must take into consideration.
1. I accept that the milk +/-LZ comparison is a feasible study and that dilutions
are a fair way forward; however you are not comparing like with like as 200ug/ml
LZ with its positive charge may be binding/interacting with other milk/bacterial
components thus modulating interactions independent of its antimicrobial
function. A good control would have been having denatured lysozyme added to
control milk. I think this aspect should be at least mentioned in the discussion.
2. Please change the y-axis for Figure 5b (upper panel) 5c appropriately.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no
Reviewer's report
Title:Goat milk with and without increased concentrations of lysozyme improves
repair of intestinal cells damage induced by enteroaggregative Escherichia coli
Version: 1Date:19 May 2012
Reviewer: Mona Bajaj-Elliott
Reviewer's report:
The paper is well written and clear in its findings. I have two comments that the
author must take into consideration.
1. I accept that the milk +/-LZ comparison is a feasible study and that dilutions
are a fair way forward; however you are not comparing like with like as 200ug/ml
LZ with its positive charge may be binding/interacting with other milk/bacterial
components thus modulating interactions independent of its antimicrobial
function. A good control would have been having denatured lysozyme added to
control milk. I think this aspect should be at least mentioned in the discussion.
2. Please change the y-axis for Figure 5b (upper panel) 5c appropriately.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no
Please review this paper.
user
Reviewer's report
Title:Goat milk with and without increased concentrations of lysozyme improves
repair of intestinal cells damage induced by enteroaggregative Escherichia coli
Version: 1Date:19 May 2012
Reviewer: Mona Bajaj-Elliott
Reviewer's report:
The paper is well written and clear in its findings. I have two comments that the
author must take into consideration.
1. I accept that the milk +/-LZ comparison is a feasible study and that dilutions
are a fair way forward; however you are not comparing like with like as 200ug/ml
LZ with its positive charge may be binding/interacting with other milk/bacterial
components thus modulating interactions independent of its antimicrobial
function. A good control would have been having denatured lysozyme added to
control milk. I think this aspect should be at least mentioned in the discussion.
2. Please change the y-axis for Figure 5b (upper panel) 5c appropriately.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no
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