Reviewer ’s report  
 
Title:  Invasive inflammatory fibroid polyp of the stomach: A case report and literature review  
 
Version: 0 Date: 08 Oct 2017 
 
Reviewer:  Noam  Harpaz  
 
Reviewer’s report:  
 
This report describes a case of a deeply infiltrative gastric IFP with transmural invasion to the 
subserosa.  Although the tumor lacked some of the classical histological and molecula r features 
of IFP, the histology and the immunohistochemial profile are well -documented and reasonably 
convincing.  One would have liked to see negative DOG -1 immunostaining along with the other 
immunostains used to exclude GIST.  In addition, more detaile d documentation of the technical 
aspects of the PDGFRA testing are warranted.  
 
Although the phenomenon of infiltrative IFP is indeed rare, the authors neglected to discuss and 
cite prior reports of infiltrative IFP of the GI tract, most of which involved no n-gastric sites.  
Examples include an ileal IFP reported by S. Takimma and K. Koda (Gastroenterology Reports 
2016) and several earlier cases of invasive IFP cited within that report.  It is recommended that 
the Discussion and References be revised accordin gly. 
 
Are the methods appropria te and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusion s drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose finan cially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hol d or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests' below  
 
I agree to the open peer review policy of the journal. I understand that my name wi ll be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available un der an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title:  Invasive inflammatory fibroid polyp of the stomach: A case report and literature review  
 
Version: 0 Date: 08 Oct 2017 
 
Reviewer:  Noam  Harpaz  
 
Reviewer’s report:  
 
This report describes a case of a deeply infiltrative gastric IFP with transmural invasion to the 
subserosa.  Although the tumor lacked some of the classical histological and molecula r features 
of IFP, the histology and the immunohistochemial profile are well -documented and reasonably 
convincing.  One would have liked to see negative DOG -1 immunostaining along with the other 
immunostains used to exclude GIST.  In addition, more detaile d documentation of the technical 
aspects of the PDGFRA testing are warranted.  
 
Although the phenomenon of infiltrative IFP is indeed rare, the authors neglected to discuss and 
cite prior reports of infiltrative IFP of the GI tract, most of which involved no n-gastric sites.  
Examples include an ileal IFP reported by S. Takimma and K. Koda (Gastroenterology Reports 
2016) and several earlier cases of invasive IFP cited within that report.  It is recommended that 
the Discussion and References be revised accordin gly. 
 
Are the methods appropria te and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusion s drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose finan cially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hol d or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests' below  
 
I agree to the open peer review policy of the journal. I understand that my name wi ll be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available un der an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title:  Invasive inflammatory fibroid polyp of the stomach: A case report and literature review  
 
Version: 0 Date: 08 Oct 2017 
 
Reviewer:  Noam  Harpaz  
 
Reviewer’s report:  
 
This report describes a case of a deeply infiltrative gastric IFP with transmural invasion to the 
subserosa.  Although the tumor lacked some of the classical histological and molecula r features 
of IFP, the histology and the immunohistochemial profile are well -documented and reasonably 
convincing.  One would have liked to see negative DOG -1 immunostaining along with the other 
immunostains used to exclude GIST.  In addition, more detaile d documentation of the technical 
aspects of the PDGFRA testing are warranted.  
 
Although the phenomenon of infiltrative IFP is indeed rare, the authors neglected to discuss and 
cite prior reports of infiltrative IFP of the GI tract, most of which involved no n-gastric sites.  
Examples include an ileal IFP reported by S. Takimma and K. Koda (Gastroenterology Reports 
2016) and several earlier cases of invasive IFP cited within that report.  It is recommended that 
the Discussion and References be revised accordin gly. 
 
Are the methods appropria te and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusion s drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose finan cially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hol d or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests' below  
 
I agree to the open peer review policy of the journal. I understand that my name wi ll be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available un der an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant