Title: Identification of changes in bile composition in pancreaticobiliary reflux based on liquid
chromatography/mass spectrometry metabolomics
Version: 1 Date: 03 Oct 2023
Reviewer:  Rajani Sharma
Reviewer's report:
The authors have well explained the relation between metabolomics and gallstone formation.
However, this is well established that gallbladder mobility is a major factor for gallstone
formation. Authors have related this fact indirectly with the existing evidence.
Scientifically the manuscript is in acceptable format with minor correction. The work lack recent
references in the discussion section which can relate the treatment process with difference in
metabolomics. As just studying the factor for gallstone formation do not direct the treatment
process.
Title: Identification of changes in bile composition in pancreaticobiliary reflux based on liquid
chromatography/mass spectrometry metabolomics
Version: 1 Date: 03 Oct 2023
Reviewer:  Rajani Sharma
Reviewer's report:
The authors have well explained the relation between metabolomics and gallstone formation.
However, this is well established that gallbladder mobility is a major factor for gallstone
formation. Authors have related this fact indirectly with the existing evidence.
Scientifically the manuscript is in acceptable format with minor correction. The work lack recent
references in the discussion section which can relate the treatment process with difference in
metabolomics. As just studying the factor for gallstone formation do not direct the treatment
process.
Please review this paper.
user
Title: Identification of changes in bile composition in pancreaticobiliary reflux based on liquid
chromatography/mass spectrometry metabolomics
Version: 1 Date: 03 Oct 2023
Reviewer:  Rajani Sharma
Reviewer's report:
The authors have well explained the relation between metabolomics and gallstone formation.
However, this is well established that gallbladder mobility is a major factor for gallstone
formation. Authors have related this fact indirectly with the existing evidence.
Scientifically the manuscript is in acceptable format with minor correction. The work lack recent
references in the discussion section which can relate the treatment process with difference in
metabolomics. As just studying the factor for gallstone formation do not direct the treatment
process.
assistant