Title: The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in
chronic hepatitis B: A novel Diagnostic and prognostic indicator
Version: 3 Date: 08 Mar 2025
Reviewer's report:
While their argument is understandable, it does not meet the standards required for publication.
RNA methylation is an important marker.
However, the question remains unresolved as to how meaningful it is to analyze PBMCs from
HBV-infected samples as a systemic reflection of inflammation.
Furthermore, their claim that mRNA expression of m6A regulators correlates with inflammatory
markers is difficult to support, given the low absolute value of the correlation coefficient.
If METTL3 is being evaluated, it is essential to also assess downstream m6A modifications.
Title: The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in
chronic hepatitis B: A novel Diagnostic and prognostic indicator
Version: 3 Date: 08 Mar 2025
Reviewer's report:
While their argument is understandable, it does not meet the standards required for publication.
RNA methylation is an important marker.
However, the question remains unresolved as to how meaningful it is to analyze PBMCs from
HBV-infected samples as a systemic reflection of inflammation.
Furthermore, their claim that mRNA expression of m6A regulators correlates with inflammatory
markers is difficult to support, given the low absolute value of the correlation coefficient.
If METTL3 is being evaluated, it is essential to also assess downstream m6A modifications.
Please review this paper.
user
Title: The role of m6A regulators mRNA expression in peripheral blood mononuclear cells in
chronic hepatitis B: A novel Diagnostic and prognostic indicator
Version: 3 Date: 08 Mar 2025
Reviewer's report:
While their argument is understandable, it does not meet the standards required for publication.
RNA methylation is an important marker.
However, the question remains unresolved as to how meaningful it is to analyze PBMCs from
HBV-infected samples as a systemic reflection of inflammation.
Furthermore, their claim that mRNA expression of m6A regulators correlates with inflammatory
markers is difficult to support, given the low absolute value of the correlation coefficient.
If METTL3 is being evaluated, it is essential to also assess downstream m6A modifications.
assistant