Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 1 Date: 16 Dec 2024
Reviewer:  Dario Parini
Reviewer's report:
Dear Authors, your paper is well written and your primary and secondary aims are clear. The
choice to consider only patients with ileostomy after surgery for cancer has limited the number
of RCTs that could be included, but, at the same time, in this way the population was more
homogeneous.
I think the discussion is well done and analyzes all the aspects that can help decide whether to
close the stoma early or not. If we consider the EC population, it would be interesting to verify
if it's possible to extract data about a possible delay in closure due to a complication of the first
intervention (eg: anastomotic leak), and how many days these complications delayed the closure.
A limitation for reviewing this specific argument is the heterogeneity in definition of early
closure, but you have well underlined this bias.
Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 1 Date: 16 Dec 2024
Reviewer:  Dario Parini
Reviewer's report:
Dear Authors, your paper is well written and your primary and secondary aims are clear. The
choice to consider only patients with ileostomy after surgery for cancer has limited the number
of RCTs that could be included, but, at the same time, in this way the population was more
homogeneous.
I think the discussion is well done and analyzes all the aspects that can help decide whether to
close the stoma early or not. If we consider the EC population, it would be interesting to verify
if it's possible to extract data about a possible delay in closure due to a complication of the first
intervention (eg: anastomotic leak), and how many days these complications delayed the closure.
A limitation for reviewing this specific argument is the heterogeneity in definition of early
closure, but you have well underlined this bias.
Please review this paper.
user
Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 1 Date: 16 Dec 2024
Reviewer:  Dario Parini
Reviewer's report:
Dear Authors, your paper is well written and your primary and secondary aims are clear. The
choice to consider only patients with ileostomy after surgery for cancer has limited the number
of RCTs that could be included, but, at the same time, in this way the population was more
homogeneous.
I think the discussion is well done and analyzes all the aspects that can help decide whether to
close the stoma early or not. If we consider the EC population, it would be interesting to verify
if it's possible to extract data about a possible delay in closure due to a complication of the first
intervention (eg: anastomotic leak), and how many days these complications delayed the closure.
A limitation for reviewing this specific argument is the heterogeneity in definition of early
closure, but you have well underlined this bias.
assistant