Reviewer's report
Title:Long-term outcomes of patients with refractory gastroesophageal reflux
disease following a minimally invasive endoscopic procedure: a prospective
observational study
Version:3Date:27 April 2014
Reviewer: mark noar
Reviewer's report:
Major Compulsory Revisions: None
Minor Essential Revisions:
1) Under the Methods-Outcome Assessment
a) Kindly specify if the questionnaires were administered on or off meds.
2) Under the Results section
a) Please indicate if the patients who complained of abdominal distention
1] How many of these patients had abdominal distention before the Stretta or
immediately after the Stretta.
2] Were patients evaluated by gastric emptying scan to determine the cause
of the symptoms either before, immediately after Stretta or at the end of
the study?
3] Is it possible to make a conclusion whether the abdominal distention was
the result of the procedure or was pre-existing?
4] Were there patients with abdominal distention before Stretta that
improved? If so please include information.
Discretionary Revisions
With regard to references please consider following suggestions:
1) Introduction - last 3 lines
a) "meta-analysis studies [16-22]. However, mixed results have been obtained.
[23]"
2) Discussion - 3rd paragraph
a) there is no reference for improvement in gastric emptying. The following is the
reference you can use:
1] Noar MD, Noar E. Gastroparesis associated with gastroesophageal reflux
disease and corresponding reflux symptoms may be corrected by
radiofrequency ablation of the cardia and esophagogastric junction. Surg
Endosc. 2008;22(11):2440-4.
b) consider adding additional documented mechanism of action of "deceased
compliance of the LES", with the following reference
2] Arts J, Bisschops R, Blondeau K, Farre´ R, Vos R, Holvoet L, Caenepeel P,
Lerut A, Tack J (2012) A double-blind sham-controlled study of the effect of
radiofrequency energy on symptoms and distensibility of the gastro-
esophageal junction in GERD. Am J Gastroenterol 107(2):222–230.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I serve as a medical advisor to Mederi Therapeutics, the current manufacturer
and owner of the patents on the Stretta technology.
Reviewer's report
Title:Long-term outcomes of patients with refractory gastroesophageal reflux
disease following a minimally invasive endoscopic procedure: a prospective
observational study
Version:3Date:27 April 2014
Reviewer: mark noar
Reviewer's report:
Major Compulsory Revisions: None
Minor Essential Revisions:
1) Under the Methods-Outcome Assessment
a) Kindly specify if the questionnaires were administered on or off meds.
2) Under the Results section
a) Please indicate if the patients who complained of abdominal distention
1] How many of these patients had abdominal distention before the Stretta or
immediately after the Stretta.
2] Were patients evaluated by gastric emptying scan to determine the cause
of the symptoms either before, immediately after Stretta or at the end of
the study?
3] Is it possible to make a conclusion whether the abdominal distention was
the result of the procedure or was pre-existing?
4] Were there patients with abdominal distention before Stretta that
improved? If so please include information.
Discretionary Revisions
With regard to references please consider following suggestions:
1) Introduction - last 3 lines
a) "meta-analysis studies [16-22]. However, mixed results have been obtained.
[23]"
2) Discussion - 3rd paragraph
a) there is no reference for improvement in gastric emptying. The following is the
reference you can use:
1] Noar MD, Noar E. Gastroparesis associated with gastroesophageal reflux
disease and corresponding reflux symptoms may be corrected by
radiofrequency ablation of the cardia and esophagogastric junction. Surg
Endosc. 2008;22(11):2440-4.
b) consider adding additional documented mechanism of action of "deceased
compliance of the LES", with the following reference
2] Arts J, Bisschops R, Blondeau K, Farre´ R, Vos R, Holvoet L, Caenepeel P,
Lerut A, Tack J (2012) A double-blind sham-controlled study of the effect of
radiofrequency energy on symptoms and distensibility of the gastro-
esophageal junction in GERD. Am J Gastroenterol 107(2):222–230.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I serve as a medical advisor to Mederi Therapeutics, the current manufacturer
and owner of the patents on the Stretta technology.
Please review this paper.
user
Reviewer's report
Title:Long-term outcomes of patients with refractory gastroesophageal reflux
disease following a minimally invasive endoscopic procedure: a prospective
observational study
Version:3Date:27 April 2014
Reviewer: mark noar
Reviewer's report:
Major Compulsory Revisions: None
Minor Essential Revisions:
1) Under the Methods-Outcome Assessment
a) Kindly specify if the questionnaires were administered on or off meds.
2) Under the Results section
a) Please indicate if the patients who complained of abdominal distention
1] How many of these patients had abdominal distention before the Stretta or
immediately after the Stretta.
2] Were patients evaluated by gastric emptying scan to determine the cause
of the symptoms either before, immediately after Stretta or at the end of
the study?
3] Is it possible to make a conclusion whether the abdominal distention was
the result of the procedure or was pre-existing?
4] Were there patients with abdominal distention before Stretta that
improved? If so please include information.
Discretionary Revisions
With regard to references please consider following suggestions:
1) Introduction - last 3 lines
a) "meta-analysis studies [16-22]. However, mixed results have been obtained.
[23]"
2) Discussion - 3rd paragraph
a) there is no reference for improvement in gastric emptying. The following is the
reference you can use:
1] Noar MD, Noar E. Gastroparesis associated with gastroesophageal reflux
disease and corresponding reflux symptoms may be corrected by
radiofrequency ablation of the cardia and esophagogastric junction. Surg
Endosc. 2008;22(11):2440-4.
b) consider adding additional documented mechanism of action of "deceased
compliance of the LES", with the following reference
2] Arts J, Bisschops R, Blondeau K, Farre´ R, Vos R, Holvoet L, Caenepeel P,
Lerut A, Tack J (2012) A double-blind sham-controlled study of the effect of
radiofrequency energy on symptoms and distensibility of the gastro-
esophageal junction in GERD. Am J Gastroenterol 107(2):222–230.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I serve as a medical advisor to Mederi Therapeutics, the current manufacturer
and owner of the patents on the Stretta technology.
assistant