Title: ANTIBIOTIC USE IN GASTROINTESTINAL SURGERY PATIENTS AT A
VIETNAMESE NATIONAL HOSPITAL
Version: 1 Date: 11 Mar 2022
Reviewer's report:
Thank you for inviting me to review the manuscript.
The manuscript is well written and provides interesting findings on the use of antibiotics in
gastro-intestinal surgery in Vietnam.
1- It may be more appropriate to include antibiotic prophylaxis as one of the measures to decrease
surgical site infections (SSI) before specifying the importance of appropriate use of prophylactic
antibiotics in clean and clean-contaminated surgery (page 3, paragraph 4).
2- The SSI’s definition is confusing. For example, it’s not clear if the positive or lack of culture
results should be associated or not to the presence of clinical sign (s) to diagnose SSI.
3- The authors stated that 14 SSI were bacterial and 25 non-bacterial. How was the diagnosis
made if no culture and/or antibiogram was done?
4- On page 5, first paragraph, the authors state “Our survey results showed that dosages of
antibiotics used differed from the recommended dosage” Please indicate the percentage of
antibiotics dosage that differed from the recommended dosage.
5- Although the authors did not find any association between the overall appropriateness of
antibiotic prophylaxis and treatment and SSI, it would be probably interesting to also evaluate the
relationship between every element of appropriateness and SSI (prophylactic antibiotic timing,
type and dosage and antibiotic treatment type, dosage, and duration) to ensure that no association
exist.
6- Page 6, second paragraph: To specify the type/parameter of appropriateness you are
discussing.
7- Page 4, line 101-103. There is a repetition of the antibiotic appropriateness definition/
evaluation.
8- Please write “materials” instead of “materitals”: page 3, “Materials and Methods”.
Title: ANTIBIOTIC USE IN GASTROINTESTINAL SURGERY PATIENTS AT A
VIETNAMESE NATIONAL HOSPITAL
Version: 1 Date: 11 Mar 2022
Reviewer's report:
Thank you for inviting me to review the manuscript.
The manuscript is well written and provides interesting findings on the use of antibiotics in
gastro-intestinal surgery in Vietnam.
1- It may be more appropriate to include antibiotic prophylaxis as one of the measures to decrease
surgical site infections (SSI) before specifying the importance of appropriate use of prophylactic
antibiotics in clean and clean-contaminated surgery (page 3, paragraph 4).
2- The SSI’s definition is confusing. For example, it’s not clear if the positive or lack of culture
results should be associated or not to the presence of clinical sign (s) to diagnose SSI.
3- The authors stated that 14 SSI were bacterial and 25 non-bacterial. How was the diagnosis
made if no culture and/or antibiogram was done?
4- On page 5, first paragraph, the authors state “Our survey results showed that dosages of
antibiotics used differed from the recommended dosage” Please indicate the percentage of
antibiotics dosage that differed from the recommended dosage.
5- Although the authors did not find any association between the overall appropriateness of
antibiotic prophylaxis and treatment and SSI, it would be probably interesting to also evaluate the
relationship between every element of appropriateness and SSI (prophylactic antibiotic timing,
type and dosage and antibiotic treatment type, dosage, and duration) to ensure that no association
exist.
6- Page 6, second paragraph: To specify the type/parameter of appropriateness you are
discussing.
7- Page 4, line 101-103. There is a repetition of the antibiotic appropriateness definition/
evaluation.
8- Please write “materials” instead of “materitals”: page 3, “Materials and Methods”.
Please review this paper.
user
Title: ANTIBIOTIC USE IN GASTROINTESTINAL SURGERY PATIENTS AT A
VIETNAMESE NATIONAL HOSPITAL
Version: 1 Date: 11 Mar 2022
Reviewer's report:
Thank you for inviting me to review the manuscript.
The manuscript is well written and provides interesting findings on the use of antibiotics in
gastro-intestinal surgery in Vietnam.
1- It may be more appropriate to include antibiotic prophylaxis as one of the measures to decrease
surgical site infections (SSI) before specifying the importance of appropriate use of prophylactic
antibiotics in clean and clean-contaminated surgery (page 3, paragraph 4).
2- The SSI’s definition is confusing. For example, it’s not clear if the positive or lack of culture
results should be associated or not to the presence of clinical sign (s) to diagnose SSI.
3- The authors stated that 14 SSI were bacterial and 25 non-bacterial. How was the diagnosis
made if no culture and/or antibiogram was done?
4- On page 5, first paragraph, the authors state “Our survey results showed that dosages of
antibiotics used differed from the recommended dosage” Please indicate the percentage of
antibiotics dosage that differed from the recommended dosage.
5- Although the authors did not find any association between the overall appropriateness of
antibiotic prophylaxis and treatment and SSI, it would be probably interesting to also evaluate the
relationship between every element of appropriateness and SSI (prophylactic antibiotic timing,
type and dosage and antibiotic treatment type, dosage, and duration) to ensure that no association
exist.
6- Page 6, second paragraph: To specify the type/parameter of appropriateness you are
discussing.
7- Page 4, line 101-103. There is a repetition of the antibiotic appropriateness definition/
evaluation.
8- Please write “materials” instead of “materitals”: page 3, “Materials and Methods”.
assistant