Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 10 Date: 12 Aug 2022
Reviewer's report:
There are several incomprehensible sentences due to changes not pointed out by the reviewer
before.
1) On page 1, lane 21: ‘Early prediction of acute pancreatitis (AP)’ does not make sense. Instead,
‘Early prediction of severe acute pancreatitis (SAP)’ makes sense.
2) On page 3, lane 11: ‘the early prediction for AP is important for severity assessments and
treatment decision’ does not make sense. Instead, ‘the early prediction for SAP is important for
treatment decision’ makes sense.
3) On page 3, lane 21: ‘serum sTIM-3 could represent an early indicator of AP’ does not make
sense. Instead, ‘serum sTIM-3 could represent an early indicator of the severity of AP’ makes
sense.
4) On page 4, lane 13: When did patients have the opportunity to refuse participation in this
retrospective study?
5) On page 15, lane 11-12: ‘Early detection of the tendency toward AP’ does not make sense.
Instead, ‘Early detection of the tendency toward SAP’ or ‘Early prediction of SAP’ may make
sense.
6) On page 15, lane 18-19: ‘The association between these indicators and the severity of AP is
controversial in previous reports.’ Reference papers should be added.
7) Retrospective nature should be listed as one of the limitations of this study.
Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 10 Date: 12 Aug 2022
Reviewer's report:
There are several incomprehensible sentences due to changes not pointed out by the reviewer
before.
1) On page 1, lane 21: ‘Early prediction of acute pancreatitis (AP)’ does not make sense. Instead,
‘Early prediction of severe acute pancreatitis (SAP)’ makes sense.
2) On page 3, lane 11: ‘the early prediction for AP is important for severity assessments and
treatment decision’ does not make sense. Instead, ‘the early prediction for SAP is important for
treatment decision’ makes sense.
3) On page 3, lane 21: ‘serum sTIM-3 could represent an early indicator of AP’ does not make
sense. Instead, ‘serum sTIM-3 could represent an early indicator of the severity of AP’ makes
sense.
4) On page 4, lane 13: When did patients have the opportunity to refuse participation in this
retrospective study?
5) On page 15, lane 11-12: ‘Early detection of the tendency toward AP’ does not make sense.
Instead, ‘Early detection of the tendency toward SAP’ or ‘Early prediction of SAP’ may make
sense.
6) On page 15, lane 18-19: ‘The association between these indicators and the severity of AP is
controversial in previous reports.’ Reference papers should be added.
7) Retrospective nature should be listed as one of the limitations of this study.
Please review this paper.
user
Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 10 Date: 12 Aug 2022
Reviewer's report:
There are several incomprehensible sentences due to changes not pointed out by the reviewer
before.
1) On page 1, lane 21: ‘Early prediction of acute pancreatitis (AP)’ does not make sense. Instead,
‘Early prediction of severe acute pancreatitis (SAP)’ makes sense.
2) On page 3, lane 11: ‘the early prediction for AP is important for severity assessments and
treatment decision’ does not make sense. Instead, ‘the early prediction for SAP is important for
treatment decision’ makes sense.
3) On page 3, lane 21: ‘serum sTIM-3 could represent an early indicator of AP’ does not make
sense. Instead, ‘serum sTIM-3 could represent an early indicator of the severity of AP’ makes
sense.
4) On page 4, lane 13: When did patients have the opportunity to refuse participation in this
retrospective study?
5) On page 15, lane 11-12: ‘Early detection of the tendency toward AP’ does not make sense.
Instead, ‘Early detection of the tendency toward SAP’ or ‘Early prediction of SAP’ may make
sense.
6) On page 15, lane 18-19: ‘The association between these indicators and the severity of AP is
controversial in previous reports.’ Reference papers should be added.
7) Retrospective nature should be listed as one of the limitations of this study.
assistant