Reviewer's report
Title:Chronic calcium pyrophosphate crystal inflammatory arthritis induced by
extreme hypomagnesemia in short bowel syndrome
Version: 1Date:21 May 2012
Reviewer: Claire Louise Donohoe
Reviewer's report:
1. General comments: This is a well written and interesting case report. The
authors note that although a rare complication of SBS, which is in itself a rare
condition, there have been other reports of CPPD associated with
hypomagnesaemia. The value of this report is that it uses the case reported to
illustrate the principles of investigation and treatment of malabsorption in the
setting of SBS. The report explores the multi-factorial aetiology of
hypomagnesaemia within the setting of SBS; illustrates in detail the thorough
multi-disciplinary assessment of hypomagnesaemia and discusses the multiple
interventions required in order to address the arthralgia with which the patient
presented.
2. Minor essential revisions
Page 2, Paragraph 4 Abstract: change colchicum to colchicines
Page 3, Paragraph 1 Abstract: change rareness to rarity
Page 4, Paragraph 2: Define BMI
Page 4, Paragraph 3: Change those to these
Page 4, Paragraph 3: Change discomforts to discomfort
Page 5, paragraph 2: First sentence does not make grammatical sense, please
re-phrase.
Page 5, paragraph 2: change vertebras to vertebrae.
Page 5, paragraph 3: Delete seeing
Page 6, paragraph 1: Delete a
Page 7, paragraph 1: Change columns to principles
Page 7, paragraph 1: Change “Due to non-steroidal drug intolerance this
group...” to “Due to the non-steroidal drug intolerance diagnosed, this group...”
Page 8, paragraph 1: Change “...while applying above listed..” to “...while
applying the above listed..”
Page 8, paragraph 2: Change “After one year treatment the...” to “After one year
of treatment the...”
Page 8, paragraph 2: Change month to months
3. Discretionary revisions –
A schematic diagram illustrating the pathophysiology of hypomagnesaemia in
SBS as detailed in the discussion would be a valuable addition to the paper.
Page 4, paragraph 3: Beware subjective attribution within this descriptive
paragraph – a description of the patient’s symptoms would be more informative
rather than the statement “slipped into depression and chronic fatigue
syndrome”. Did the patient meet DSM criteria for depression? Was he
undergoing treatment for depression? How was the reported chronic fatigue
syndrome defined? These questions can be avoided by describing the patient’s
symptoms.
Page 8, paragraph 2: Is it common psychiatric practice to use anti-depressants in
an on-demand schedule?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Chronic calcium pyrophosphate crystal inflammatory arthritis induced by
extreme hypomagnesemia in short bowel syndrome
Version: 1Date:21 May 2012
Reviewer: Claire Louise Donohoe
Reviewer's report:
1. General comments: This is a well written and interesting case report. The
authors note that although a rare complication of SBS, which is in itself a rare
condition, there have been other reports of CPPD associated with
hypomagnesaemia. The value of this report is that it uses the case reported to
illustrate the principles of investigation and treatment of malabsorption in the
setting of SBS. The report explores the multi-factorial aetiology of
hypomagnesaemia within the setting of SBS; illustrates in detail the thorough
multi-disciplinary assessment of hypomagnesaemia and discusses the multiple
interventions required in order to address the arthralgia with which the patient
presented.
2. Minor essential revisions
Page 2, Paragraph 4 Abstract: change colchicum to colchicines
Page 3, Paragraph 1 Abstract: change rareness to rarity
Page 4, Paragraph 2: Define BMI
Page 4, Paragraph 3: Change those to these
Page 4, Paragraph 3: Change discomforts to discomfort
Page 5, paragraph 2: First sentence does not make grammatical sense, please
re-phrase.
Page 5, paragraph 2: change vertebras to vertebrae.
Page 5, paragraph 3: Delete seeing
Page 6, paragraph 1: Delete a
Page 7, paragraph 1: Change columns to principles
Page 7, paragraph 1: Change “Due to non-steroidal drug intolerance this
group...” to “Due to the non-steroidal drug intolerance diagnosed, this group...”
Page 8, paragraph 1: Change “...while applying above listed..” to “...while
applying the above listed..”
Page 8, paragraph 2: Change “After one year treatment the...” to “After one year
of treatment the...”
Page 8, paragraph 2: Change month to months
3. Discretionary revisions –
A schematic diagram illustrating the pathophysiology of hypomagnesaemia in
SBS as detailed in the discussion would be a valuable addition to the paper.
Page 4, paragraph 3: Beware subjective attribution within this descriptive
paragraph – a description of the patient’s symptoms would be more informative
rather than the statement “slipped into depression and chronic fatigue
syndrome”. Did the patient meet DSM criteria for depression? Was he
undergoing treatment for depression? How was the reported chronic fatigue
syndrome defined? These questions can be avoided by describing the patient’s
symptoms.
Page 8, paragraph 2: Is it common psychiatric practice to use anti-depressants in
an on-demand schedule?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Chronic calcium pyrophosphate crystal inflammatory arthritis induced by
extreme hypomagnesemia in short bowel syndrome
Version: 1Date:21 May 2012
Reviewer: Claire Louise Donohoe
Reviewer's report:
1. General comments: This is a well written and interesting case report. The
authors note that although a rare complication of SBS, which is in itself a rare
condition, there have been other reports of CPPD associated with
hypomagnesaemia. The value of this report is that it uses the case reported to
illustrate the principles of investigation and treatment of malabsorption in the
setting of SBS. The report explores the multi-factorial aetiology of
hypomagnesaemia within the setting of SBS; illustrates in detail the thorough
multi-disciplinary assessment of hypomagnesaemia and discusses the multiple
interventions required in order to address the arthralgia with which the patient
presented.
2. Minor essential revisions
Page 2, Paragraph 4 Abstract: change colchicum to colchicines
Page 3, Paragraph 1 Abstract: change rareness to rarity
Page 4, Paragraph 2: Define BMI
Page 4, Paragraph 3: Change those to these
Page 4, Paragraph 3: Change discomforts to discomfort
Page 5, paragraph 2: First sentence does not make grammatical sense, please
re-phrase.
Page 5, paragraph 2: change vertebras to vertebrae.
Page 5, paragraph 3: Delete seeing
Page 6, paragraph 1: Delete a
Page 7, paragraph 1: Change columns to principles
Page 7, paragraph 1: Change “Due to non-steroidal drug intolerance this
group...” to “Due to the non-steroidal drug intolerance diagnosed, this group...”
Page 8, paragraph 1: Change “...while applying above listed..” to “...while
applying the above listed..”
Page 8, paragraph 2: Change “After one year treatment the...” to “After one year
of treatment the...”
Page 8, paragraph 2: Change month to months
3. Discretionary revisions –
A schematic diagram illustrating the pathophysiology of hypomagnesaemia in
SBS as detailed in the discussion would be a valuable addition to the paper.
Page 4, paragraph 3: Beware subjective attribution within this descriptive
paragraph – a description of the patient’s symptoms would be more informative
rather than the statement “slipped into depression and chronic fatigue
syndrome”. Did the patient meet DSM criteria for depression? Was he
undergoing treatment for depression? How was the reported chronic fatigue
syndrome defined? These questions can be avoided by describing the patient’s
symptoms.
Page 8, paragraph 2: Is it common psychiatric practice to use anti-depressants in
an on-demand schedule?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant