Reviewer's report 
 The Canadian Celiac Health Survey - The Ottawa Chapter Pilot Title: 
Authors: 
Dr Ann B Cranney ( cranneya@kgh.kari.net )
Marion Zarkadas ( czarkadas@sympatico.ca )
Dr Ian ID Graham Dr. ( igraham@ohri.ca )
Connie CM Switzer Dr. ( cmswitzer@shaw.ca )
 3  24 Apr 2003 Version: Date: 
 Carlo Catassi Reviewer: 
 A paper whose findings are important to those with closely related research Level of interest: 
interests 
 Accept after discretionary revisions Advice on publication: 
The revised manuscript is greatly improved compared with the original version. I have only some 
minor suggestions: - page 2 introduction line 1: I would prefer to define celiac disease as an immune-mediated rather 
than auto-immune disorder. 
- page 2 introduction line 3: the celiac enteropathy is caused not only by gliadins. Glutenines seem to 
be toxic as well. It is probably better to generically define as toxic the gluten proteins contained in 
wheat, rye and barley. 
- page 5 Demographics: the mean age at diagnosis was quite high (45 yrs)in this study-group. This 
result could deserve a comment in the discussion. Could this be due to lower frequency of typical, early-onset cases of celiac disease? Or is it just a question of study-group selection? 
Competing interests: 
None declared. 
Reviewer's report 
 The Canadian Celiac Health Survey - The Ottawa Chapter Pilot Title: 
Authors: 
Dr Ann B Cranney ( cranneya@kgh.kari.net )
Marion Zarkadas ( czarkadas@sympatico.ca )
Dr Ian ID Graham Dr. ( igraham@ohri.ca )
Connie CM Switzer Dr. ( cmswitzer@shaw.ca )
 3  24 Apr 2003 Version: Date: 
 Carlo Catassi Reviewer: 
 A paper whose findings are important to those with closely related research Level of interest: 
interests 
 Accept after discretionary revisions Advice on publication: 
The revised manuscript is greatly improved compared with the original version. I have only some 
minor suggestions: - page 2 introduction line 1: I would prefer to define celiac disease as an immune-mediated rather 
than auto-immune disorder. 
- page 2 introduction line 3: the celiac enteropathy is caused not only by gliadins. Glutenines seem to 
be toxic as well. It is probably better to generically define as toxic the gluten proteins contained in 
wheat, rye and barley. 
- page 5 Demographics: the mean age at diagnosis was quite high (45 yrs)in this study-group. This 
result could deserve a comment in the discussion. Could this be due to lower frequency of typical, early-onset cases of celiac disease? Or is it just a question of study-group selection? 
Competing interests: 
None declared. 
Please review this paper.
user
Reviewer's report 
 The Canadian Celiac Health Survey - The Ottawa Chapter Pilot Title: 
Authors: 
Dr Ann B Cranney ( cranneya@kgh.kari.net )
Marion Zarkadas ( czarkadas@sympatico.ca )
Dr Ian ID Graham Dr. ( igraham@ohri.ca )
Connie CM Switzer Dr. ( cmswitzer@shaw.ca )
 3  24 Apr 2003 Version: Date: 
 Carlo Catassi Reviewer: 
 A paper whose findings are important to those with closely related research Level of interest: 
interests 
 Accept after discretionary revisions Advice on publication: 
The revised manuscript is greatly improved compared with the original version. I have only some 
minor suggestions: - page 2 introduction line 1: I would prefer to define celiac disease as an immune-mediated rather 
than auto-immune disorder. 
- page 2 introduction line 3: the celiac enteropathy is caused not only by gliadins. Glutenines seem to 
be toxic as well. It is probably better to generically define as toxic the gluten proteins contained in 
wheat, rye and barley. 
- page 5 Demographics: the mean age at diagnosis was quite high (45 yrs)in this study-group. This 
result could deserve a comment in the discussion. Could this be due to lower frequency of typical, early-onset cases of celiac disease? Or is it just a question of study-group selection? 
Competing interests: 
None declared. 
assistant