Reviewer's report
Title:Low prevalence of H. pylori Infection in HIV-Positive Patients in the
Northeast of Brazil
Version: 1Date:7 March 2010
Reviewer: Tomohiko Shimatani
Reviewer's report:
In this manuscript, the authors determined significant lower prevalence of H.
pylori infection in HIV-positive patients than that in HIV-negative patients, and no
association between H. pylori status and chronic active body gastritis in
HIV-positive patients. The study was well performed and very interesting. The
reviewer considered any particular critical problems were not found, however,
some questions have been raised as follows:
1. In this study, H. pylori status was determined by the rapid urease test and
histology. Why did the authors use the 13C urea breath test or H. pylori stool
antigen?
2. As the authors discussed, the mechanism of chronic active gastritis in the
gastric body in HIV-positive patients may be different from that in HIV-negative
patients. Other microorganisms, or some drugs using in the treatment of HIV,
may play a role. Some more precise explanations will be requited in the
discussion session.
3. ‘Figure 1’ was not attached on the text file.
4. Grammatical errors and misspellings could not be negligible. In particular,
definite articles (i.e., the) were not adequately used. Please be checked by an
English copyeditor.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Low prevalence of H. pylori Infection in HIV-Positive Patients in the
Northeast of Brazil
Version: 1Date:7 March 2010
Reviewer: Tomohiko Shimatani
Reviewer's report:
In this manuscript, the authors determined significant lower prevalence of H.
pylori infection in HIV-positive patients than that in HIV-negative patients, and no
association between H. pylori status and chronic active body gastritis in
HIV-positive patients. The study was well performed and very interesting. The
reviewer considered any particular critical problems were not found, however,
some questions have been raised as follows:
1. In this study, H. pylori status was determined by the rapid urease test and
histology. Why did the authors use the 13C urea breath test or H. pylori stool
antigen?
2. As the authors discussed, the mechanism of chronic active gastritis in the
gastric body in HIV-positive patients may be different from that in HIV-negative
patients. Other microorganisms, or some drugs using in the treatment of HIV,
may play a role. Some more precise explanations will be requited in the
discussion session.
3. ‘Figure 1’ was not attached on the text file.
4. Grammatical errors and misspellings could not be negligible. In particular,
definite articles (i.e., the) were not adequately used. Please be checked by an
English copyeditor.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Low prevalence of H. pylori Infection in HIV-Positive Patients in the
Northeast of Brazil
Version: 1Date:7 March 2010
Reviewer: Tomohiko Shimatani
Reviewer's report:
In this manuscript, the authors determined significant lower prevalence of H.
pylori infection in HIV-positive patients than that in HIV-negative patients, and no
association between H. pylori status and chronic active body gastritis in
HIV-positive patients. The study was well performed and very interesting. The
reviewer considered any particular critical problems were not found, however,
some questions have been raised as follows:
1. In this study, H. pylori status was determined by the rapid urease test and
histology. Why did the authors use the 13C urea breath test or H. pylori stool
antigen?
2. As the authors discussed, the mechanism of chronic active gastritis in the
gastric body in HIV-positive patients may be different from that in HIV-negative
patients. Other microorganisms, or some drugs using in the treatment of HIV,
may play a role. Some more precise explanations will be requited in the
discussion session.
3. ‘Figure 1’ was not attached on the text file.
4. Grammatical errors and misspellings could not be negligible. In particular,
definite articles (i.e., the) were not adequately used. Please be checked by an
English copyeditor.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
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