Title: A Systems Biology Approach to Pathogenesis of Gastric Cancer: Gene Network Modeling
and Pathway Analysis
Version: 0 Date: 27 May 2023
Reviewer's report:
In the sentences" Selection of the genes involved in gastric carcinogenesis In our previous
studies [12-14], representative overexpressed genes in GC were identified by SSH. In the current
study, the genes identified as overexpressed genes in GC in these three studies were selected
for network analysis (Table 1).“ the data used were not introduced. Furthermore, the method of
analysis and selection of overexposed genes was not mentioned. This section should be revised.
In the section " Reconstruction of genes and PPI networks and the hub analysis"  which genes
were used for PPI network analysis?
Did the authors validate Eleven hub genes in another data?
Title: A Systems Biology Approach to Pathogenesis of Gastric Cancer: Gene Network Modeling
and Pathway Analysis
Version: 0 Date: 27 May 2023
Reviewer's report:
In the sentences" Selection of the genes involved in gastric carcinogenesis In our previous
studies [12-14], representative overexpressed genes in GC were identified by SSH. In the current
study, the genes identified as overexpressed genes in GC in these three studies were selected
for network analysis (Table 1).“ the data used were not introduced. Furthermore, the method of
analysis and selection of overexposed genes was not mentioned. This section should be revised.
In the section " Reconstruction of genes and PPI networks and the hub analysis"  which genes
were used for PPI network analysis?
Did the authors validate Eleven hub genes in another data?
Please review this paper.
user
Title: A Systems Biology Approach to Pathogenesis of Gastric Cancer: Gene Network Modeling
and Pathway Analysis
Version: 0 Date: 27 May 2023
Reviewer's report:
In the sentences" Selection of the genes involved in gastric carcinogenesis In our previous
studies [12-14], representative overexpressed genes in GC were identified by SSH. In the current
study, the genes identified as overexpressed genes in GC in these three studies were selected
for network analysis (Table 1).“ the data used were not introduced. Furthermore, the method of
analysis and selection of overexposed genes was not mentioned. This section should be revised.
In the section " Reconstruction of genes and PPI networks and the hub analysis"  which genes
were used for PPI network analysis?
Did the authors validate Eleven hub genes in another data?
assistant