Reviewer's report
Title:Nutrigenomics Therapy of HCV Hepatosteatosis
Version: 4Date:7 October 2009
Reviewer: Giuliano Ramadori
Reviewer's report:
This review on ‚nutrigenomics’ in HCV-related liver steatosis addresses in a first
instance the effects of fatty acids and dietary fat composition on transcriptional
activity of genes involved both in carbohydrate and lipid metabolism.
This is a comprehensive review on a relevant topic. Some points, however, need
to be addressed:
1. Abstract – Methods: PubMed search is given as the only method that has
been applied. However, a description of the method (apart from the 4 keywords:
e.g. which publication period was searched, were only articles in English
considered or also others?) and the results are given in no place (How many
matches?). Possibly a structured abstract with a method section is not
appropriate for a review.
2. Abstract – Results: The content of this para does not cover the content of the
review.
3. The term ‘transcription genes’ first mentioned on page 6, 2nd para, is
misleading.
4. Ref 9 might be substituted by a review which focuses on HCV genomic
organisation, e.g. one by Ralf Bartenschlager.
5. In the context of steatosis and VLDL assembly, the authors should refer to
hypolipoproteinemia in HCV-related steatosis. The mentioning of the fact that
PPAR agonists ameliorate hyperlipidemia in humans and mice is misleading
(pages 9 and 10).
6. Many spelling errors, i.e. even within the author name and the department,
need to be deleted, and the manuscript needs a careful language editing.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing intersts' below
Reviewer's report
Title:Nutrigenomics Therapy of HCV Hepatosteatosis
Version: 4Date:7 October 2009
Reviewer: Giuliano Ramadori
Reviewer's report:
This review on ‚nutrigenomics’ in HCV-related liver steatosis addresses in a first
instance the effects of fatty acids and dietary fat composition on transcriptional
activity of genes involved both in carbohydrate and lipid metabolism.
This is a comprehensive review on a relevant topic. Some points, however, need
to be addressed:
1. Abstract – Methods: PubMed search is given as the only method that has
been applied. However, a description of the method (apart from the 4 keywords:
e.g. which publication period was searched, were only articles in English
considered or also others?) and the results are given in no place (How many
matches?). Possibly a structured abstract with a method section is not
appropriate for a review.
2. Abstract – Results: The content of this para does not cover the content of the
review.
3. The term ‘transcription genes’ first mentioned on page 6, 2nd para, is
misleading.
4. Ref 9 might be substituted by a review which focuses on HCV genomic
organisation, e.g. one by Ralf Bartenschlager.
5. In the context of steatosis and VLDL assembly, the authors should refer to
hypolipoproteinemia in HCV-related steatosis. The mentioning of the fact that
PPAR agonists ameliorate hyperlipidemia in humans and mice is misleading
(pages 9 and 10).
6. Many spelling errors, i.e. even within the author name and the department,
need to be deleted, and the manuscript needs a careful language editing.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing intersts' below
Please review this paper.
user
Reviewer's report
Title:Nutrigenomics Therapy of HCV Hepatosteatosis
Version: 4Date:7 October 2009
Reviewer: Giuliano Ramadori
Reviewer's report:
This review on ‚nutrigenomics’ in HCV-related liver steatosis addresses in a first
instance the effects of fatty acids and dietary fat composition on transcriptional
activity of genes involved both in carbohydrate and lipid metabolism.
This is a comprehensive review on a relevant topic. Some points, however, need
to be addressed:
1. Abstract – Methods: PubMed search is given as the only method that has
been applied. However, a description of the method (apart from the 4 keywords:
e.g. which publication period was searched, were only articles in English
considered or also others?) and the results are given in no place (How many
matches?). Possibly a structured abstract with a method section is not
appropriate for a review.
2. Abstract – Results: The content of this para does not cover the content of the
review.
3. The term ‘transcription genes’ first mentioned on page 6, 2nd para, is
misleading.
4. Ref 9 might be substituted by a review which focuses on HCV genomic
organisation, e.g. one by Ralf Bartenschlager.
5. In the context of steatosis and VLDL assembly, the authors should refer to
hypolipoproteinemia in HCV-related steatosis. The mentioning of the fact that
PPAR agonists ameliorate hyperlipidemia in humans and mice is misleading
(pages 9 and 10).
6. Many spelling errors, i.e. even within the author name and the department,
need to be deleted, and the manuscript needs a careful language editing.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing intersts' below
assistant