Reviewer's report
Title:Liver regeneration: Immunohistochemichal study of intrinsic hepatic
innervation after partial hepatectomy in rats.
Version:2Date:19 September 2014
Reviewer: Shintaro Yagi
Reviewer's report:
Kandiis et al. reported the regeneration of the hepatic innervation after partial
hepatectomy. The manuscript is well written and the report of the regeneration of
the innervation in the regenerating liver is rare but important.
Major Compulsory Revisions
1. Is there any relevance between regeneration of innervation and the liver
regenelation such as liver weight (%SLV), Ki67 of the hepatocytes etc.
2. Please discuss the role of the hepatic innervation.Is there any phigiological
parameter regarding regeneration of the hepatic innervation?
3. In the discussion section (P8, L252), it is difficult to mention that the peak of
the GAP-43 was at 3 month, because the interval of the measured point is too
long.
4. Please mention clearly what is the "control group" (P7 L206).
5. Why the regeneration of the innervation was stopped at 6m after hepatectomy,
even the PTs (+)/total PTs(%) was only 56,33.
Minor Essential Revisions
1. Figure 1 and 2, Figure 4 and 5 should be combined.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Liver regeneration: Immunohistochemichal study of intrinsic hepatic
innervation after partial hepatectomy in rats.
Version:2Date:19 September 2014
Reviewer: Shintaro Yagi
Reviewer's report:
Kandiis et al. reported the regeneration of the hepatic innervation after partial
hepatectomy. The manuscript is well written and the report of the regeneration of
the innervation in the regenerating liver is rare but important.
Major Compulsory Revisions
1. Is there any relevance between regeneration of innervation and the liver
regenelation such as liver weight (%SLV), Ki67 of the hepatocytes etc.
2. Please discuss the role of the hepatic innervation.Is there any phigiological
parameter regarding regeneration of the hepatic innervation?
3. In the discussion section (P8, L252), it is difficult to mention that the peak of
the GAP-43 was at 3 month, because the interval of the measured point is too
long.
4. Please mention clearly what is the "control group" (P7 L206).
5. Why the regeneration of the innervation was stopped at 6m after hepatectomy,
even the PTs (+)/total PTs(%) was only 56,33.
Minor Essential Revisions
1. Figure 1 and 2, Figure 4 and 5 should be combined.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Liver regeneration: Immunohistochemichal study of intrinsic hepatic
innervation after partial hepatectomy in rats.
Version:2Date:19 September 2014
Reviewer: Shintaro Yagi
Reviewer's report:
Kandiis et al. reported the regeneration of the hepatic innervation after partial
hepatectomy. The manuscript is well written and the report of the regeneration of
the innervation in the regenerating liver is rare but important.
Major Compulsory Revisions
1. Is there any relevance between regeneration of innervation and the liver
regenelation such as liver weight (%SLV), Ki67 of the hepatocytes etc.
2. Please discuss the role of the hepatic innervation.Is there any phigiological
parameter regarding regeneration of the hepatic innervation?
3. In the discussion section (P8, L252), it is difficult to mention that the peak of
the GAP-43 was at 3 month, because the interval of the measured point is too
long.
4. Please mention clearly what is the "control group" (P7 L206).
5. Why the regeneration of the innervation was stopped at 6m after hepatectomy,
even the PTs (+)/total PTs(%) was only 56,33.
Minor Essential Revisions
1. Figure 1 and 2, Figure 4 and 5 should be combined.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests.
assistant