Title: Prognostic factors of pancreatic tumors in children and adolescents: A population study
based on the Surveillance, Epidemiology, and End Results Database
Version: 7 Date: 25 Jan 2024
Reviewer's report:
This retrospective study examines prognostic factors for pancreatic tumors in 195 pediatric
patients, using the population-based SEER database from 1975-2018. The authors have
previously addressed general limitations regarding the lack of clinical details and treatment
response data in the database. However, despite the authors' analysis, I still have reservations
about the ability to overcome selection and information biases, e.g. the use of surgery is likely
heavily confounded by disease stage/biology, skewing its association with better survival;
details on surgical extent could significantly modify the interpretation of this major result; data
constraints broadly limit accounting for confounding influences on both treatment decisions and
outcomes
Given the grounded limitations of the analysis and the database, I do not believe that deeper
analysis would substantially improve or benefit the manuscript. I will respect the editor's final
decision on publication appropriateness.
Title: Prognostic factors of pancreatic tumors in children and adolescents: A population study
based on the Surveillance, Epidemiology, and End Results Database
Version: 7 Date: 25 Jan 2024
Reviewer's report:
This retrospective study examines prognostic factors for pancreatic tumors in 195 pediatric
patients, using the population-based SEER database from 1975-2018. The authors have
previously addressed general limitations regarding the lack of clinical details and treatment
response data in the database. However, despite the authors' analysis, I still have reservations
about the ability to overcome selection and information biases, e.g. the use of surgery is likely
heavily confounded by disease stage/biology, skewing its association with better survival;
details on surgical extent could significantly modify the interpretation of this major result; data
constraints broadly limit accounting for confounding influences on both treatment decisions and
outcomes
Given the grounded limitations of the analysis and the database, I do not believe that deeper
analysis would substantially improve or benefit the manuscript. I will respect the editor's final
decision on publication appropriateness.
Please review this paper.
user
Title: Prognostic factors of pancreatic tumors in children and adolescents: A population study
based on the Surveillance, Epidemiology, and End Results Database
Version: 7 Date: 25 Jan 2024
Reviewer's report:
This retrospective study examines prognostic factors for pancreatic tumors in 195 pediatric
patients, using the population-based SEER database from 1975-2018. The authors have
previously addressed general limitations regarding the lack of clinical details and treatment
response data in the database. However, despite the authors' analysis, I still have reservations
about the ability to overcome selection and information biases, e.g. the use of surgery is likely
heavily confounded by disease stage/biology, skewing its association with better survival;
details on surgical extent could significantly modify the interpretation of this major result; data
constraints broadly limit accounting for confounding influences on both treatment decisions and
outcomes
Given the grounded limitations of the analysis and the database, I do not believe that deeper
analysis would substantially improve or benefit the manuscript. I will respect the editor's final
decision on publication appropriateness.
assistant