Title: Iceball Growth 3D Simulation Model Based on Finite Element Method for Hepatic
Cryoablation Planning
Version: 0 Date: 30 Jan 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is an excellent manuscript on a 3D simulation model for hepatic
cry-ablation planning.  The paper has been written well and the descriptions are accurate.
However, my concerns are related to the real life use of this technology.  The formulas that
were used seem to be pretty complicated for an average physician.  With these technologies, the
devices come with a guide for ablation sizes based on ablation parameters, which are generally
approximate, as the authors data also showed. so, it is difficult to understand how this study will
change our day  to day care.  Who will be calculating these? my other specific questions would
be:1. Please explain the parameters used for calculations in a simple fashion, if can be brought
to that level. 2.Do the calculation incorporate patient specific parameters, like tumor type,
underlying liver condition and vessel proximity? 3.  Why do the authors thing the variability was
related? 4. Taking into account  that all ablation devices come with similar ablation parameter
vs ablation zone calculations, how do they think this will be different to change how we do
ablations? 5.  The Discussion is too long and can be shortened about 20-30% at least.
ADDITIONAL REQUESTS/SUGGESTIONS:
The main issue is how this will change our routine in real life.
Title: Iceball Growth 3D Simulation Model Based on Finite Element Method for Hepatic
Cryoablation Planning
Version: 0 Date: 30 Jan 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is an excellent manuscript on a 3D simulation model for hepatic
cry-ablation planning.  The paper has been written well and the descriptions are accurate.
However, my concerns are related to the real life use of this technology.  The formulas that
were used seem to be pretty complicated for an average physician.  With these technologies, the
devices come with a guide for ablation sizes based on ablation parameters, which are generally
approximate, as the authors data also showed. so, it is difficult to understand how this study will
change our day  to day care.  Who will be calculating these? my other specific questions would
be:1. Please explain the parameters used for calculations in a simple fashion, if can be brought
to that level. 2.Do the calculation incorporate patient specific parameters, like tumor type,
underlying liver condition and vessel proximity? 3.  Why do the authors thing the variability was
related? 4. Taking into account  that all ablation devices come with similar ablation parameter
vs ablation zone calculations, how do they think this will be different to change how we do
ablations? 5.  The Discussion is too long and can be shortened about 20-30% at least.
ADDITIONAL REQUESTS/SUGGESTIONS:
The main issue is how this will change our routine in real life.
Please review this paper.
user
Title: Iceball Growth 3D Simulation Model Based on Finite Element Method for Hepatic
Cryoablation Planning
Version: 0 Date: 30 Jan 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is an excellent manuscript on a 3D simulation model for hepatic
cry-ablation planning.  The paper has been written well and the descriptions are accurate.
However, my concerns are related to the real life use of this technology.  The formulas that
were used seem to be pretty complicated for an average physician.  With these technologies, the
devices come with a guide for ablation sizes based on ablation parameters, which are generally
approximate, as the authors data also showed. so, it is difficult to understand how this study will
change our day  to day care.  Who will be calculating these? my other specific questions would
be:1. Please explain the parameters used for calculations in a simple fashion, if can be brought
to that level. 2.Do the calculation incorporate patient specific parameters, like tumor type,
underlying liver condition and vessel proximity? 3.  Why do the authors thing the variability was
related? 4. Taking into account  that all ablation devices come with similar ablation parameter
vs ablation zone calculations, how do they think this will be different to change how we do
ablations? 5.  The Discussion is too long and can be shortened about 20-30% at least.
ADDITIONAL REQUESTS/SUGGESTIONS:
The main issue is how this will change our routine in real life.
assistant