Reviewer's report
Title:Attenuated antigen-specific T cell responses in cirrhosis are accompanied
by elevated serum interleukin-10 levels and down-regulation of HLA-DR on
monocytes
Version: 3Date:7 February 2013
Reviewer: Pilar Garcia-Peñarrubia
Reviewer's report:
Comment of the Reviewer: Pilar García Peñarrubia
The manuscript by Jack Peter and colleagues entitled: “Attenuated
antigen-specific responses in cirrhosis are accompanied by elevated serum
interleukin-10 levels and down-regulation of HLA-DR on monocytes” aims to
evaluate the cellular immune status in cirrhotic patients related with the presence
or absence of inflammatory processes. To accomplish this goal they determined
antigen-specific T cell response towards EBV derived peptides EBNA1 and
BZLF1 from two groups of cirrhotic patients (without inflammation vs
inflammation, according to CRP lower or higher than 10 mg/ml, respectively). As
control group they used peripheral blood leukocytes from healthy donors.
I stated in the first revision, that although the topic is potentially interesting, it was
suffering from a non-very coherent analysis and presentation of the results
according to the proposed aims and the discussion section.
The manuscript has been now thoroughly revised, and the data are presented in
a more understandable way, and more accordingly with the negative results
found in this study as regards to the proposed hypothesis.
I agree that publication of negative results is not very exciting, but it can avoid
others expending their time searching in the same hypothesis.
I now recommend its publication in BMC Gastroenterology.
Minor essential revision: Figure 3C, y-axis must say CD8 instead of CD4.
Level of interest: An article of sufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Still needs minor typographic corrections before being
published
Statistical review: No
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Attenuated antigen-specific T cell responses in cirrhosis are accompanied
by elevated serum interleukin-10 levels and down-regulation of HLA-DR on
monocytes
Version: 3Date:7 February 2013
Reviewer: Pilar Garcia-Peñarrubia
Reviewer's report:
Comment of the Reviewer: Pilar García Peñarrubia
The manuscript by Jack Peter and colleagues entitled: “Attenuated
antigen-specific responses in cirrhosis are accompanied by elevated serum
interleukin-10 levels and down-regulation of HLA-DR on monocytes” aims to
evaluate the cellular immune status in cirrhotic patients related with the presence
or absence of inflammatory processes. To accomplish this goal they determined
antigen-specific T cell response towards EBV derived peptides EBNA1 and
BZLF1 from two groups of cirrhotic patients (without inflammation vs
inflammation, according to CRP lower or higher than 10 mg/ml, respectively). As
control group they used peripheral blood leukocytes from healthy donors.
I stated in the first revision, that although the topic is potentially interesting, it was
suffering from a non-very coherent analysis and presentation of the results
according to the proposed aims and the discussion section.
The manuscript has been now thoroughly revised, and the data are presented in
a more understandable way, and more accordingly with the negative results
found in this study as regards to the proposed hypothesis.
I agree that publication of negative results is not very exciting, but it can avoid
others expending their time searching in the same hypothesis.
I now recommend its publication in BMC Gastroenterology.
Minor essential revision: Figure 3C, y-axis must say CD8 instead of CD4.
Level of interest: An article of sufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Still needs minor typographic corrections before being
published
Statistical review: No
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Attenuated antigen-specific T cell responses in cirrhosis are accompanied
by elevated serum interleukin-10 levels and down-regulation of HLA-DR on
monocytes
Version: 3Date:7 February 2013
Reviewer: Pilar Garcia-Peñarrubia
Reviewer's report:
Comment of the Reviewer: Pilar García Peñarrubia
The manuscript by Jack Peter and colleagues entitled: “Attenuated
antigen-specific responses in cirrhosis are accompanied by elevated serum
interleukin-10 levels and down-regulation of HLA-DR on monocytes” aims to
evaluate the cellular immune status in cirrhotic patients related with the presence
or absence of inflammatory processes. To accomplish this goal they determined
antigen-specific T cell response towards EBV derived peptides EBNA1 and
BZLF1 from two groups of cirrhotic patients (without inflammation vs
inflammation, according to CRP lower or higher than 10 mg/ml, respectively). As
control group they used peripheral blood leukocytes from healthy donors.
I stated in the first revision, that although the topic is potentially interesting, it was
suffering from a non-very coherent analysis and presentation of the results
according to the proposed aims and the discussion section.
The manuscript has been now thoroughly revised, and the data are presented in
a more understandable way, and more accordingly with the negative results
found in this study as regards to the proposed hypothesis.
I agree that publication of negative results is not very exciting, but it can avoid
others expending their time searching in the same hypothesis.
I now recommend its publication in BMC Gastroenterology.
Minor essential revision: Figure 3C, y-axis must say CD8 instead of CD4.
Level of interest: An article of sufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Still needs minor typographic corrections before being
published
Statistical review: No
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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