Title: Dual energy CT-derived quantitative parameters and hematological characteristics predict
pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell
carcinoma patients
Version: 2 Date: 12 Jan 2025
Reviewer's report:
The present work is of interest. Howeer, there are some major points to address:
Introduction:
please give an overview about the possibility to predict pCR based on different imaging findings/
imaging biomarkers.
M&M
More data about the included tumors should be added: Tumor grade, proliferation index KI67,
lymphovascular invasion, perineural invasion.
Results:
Associations between tumor grade, stage, vessel invasion, Ki 67 and iodine accumulation should
be added.
I suggest, the authors should use normalized values of the iodine accumulation in every phase.
Discussion
A ore detailed explanation of ssociations between iodine accumulation and  pCR.
Associations with histopathology?
References: some references should be added and discussed.
Figures: well
Title: Dual energy CT-derived quantitative parameters and hematological characteristics predict
pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell
carcinoma patients
Version: 2 Date: 12 Jan 2025
Reviewer's report:
The present work is of interest. Howeer, there are some major points to address:
Introduction:
please give an overview about the possibility to predict pCR based on different imaging findings/
imaging biomarkers.
M&M
More data about the included tumors should be added: Tumor grade, proliferation index KI67,
lymphovascular invasion, perineural invasion.
Results:
Associations between tumor grade, stage, vessel invasion, Ki 67 and iodine accumulation should
be added.
I suggest, the authors should use normalized values of the iodine accumulation in every phase.
Discussion
A ore detailed explanation of ssociations between iodine accumulation and  pCR.
Associations with histopathology?
References: some references should be added and discussed.
Figures: well
Please review this paper.
user
Title: Dual energy CT-derived quantitative parameters and hematological characteristics predict
pathological complete response in neoadjuvant chemoradiotherapy esophageal squamous cell
carcinoma patients
Version: 2 Date: 12 Jan 2025
Reviewer's report:
The present work is of interest. Howeer, there are some major points to address:
Introduction:
please give an overview about the possibility to predict pCR based on different imaging findings/
imaging biomarkers.
M&M
More data about the included tumors should be added: Tumor grade, proliferation index KI67,
lymphovascular invasion, perineural invasion.
Results:
Associations between tumor grade, stage, vessel invasion, Ki 67 and iodine accumulation should
be added.
I suggest, the authors should use normalized values of the iodine accumulation in every phase.
Discussion
A ore detailed explanation of ssociations between iodine accumulation and  pCR.
Associations with histopathology?
References: some references should be added and discussed.
Figures: well
assistant