Title: Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk
factor of colorectal polyps: a retrospective study in China
Version: 2 Date: 19 Dec 2022
Reviewer:  Tran Tien Dao
Reviewer's report:
Recent trends have identified an increasing number of individuals with rectal and colon cancers.
However, it is difficult to detect CRC early due to the lack of typical clinical symptoms.
Colorectal adenomatous polyps are the most important precancerous lesions, developing into
CRC through the adenomatous cancer sequence. Therefore, early screening and detection of
precancerous lesions can prevent the occurrence and development of CRC. Gastric Helicobacter
pylori and the chronic inflammatory state caused by H. pylori infection are closely related to
the occurrence of gastric cancer. Besides, previous studies have indicated that gastric H. pylori
infection increased the risk of colorectal tumors. In contrast, however, several other reports have
concluded that gastric H. pylori infection was not correlated with colorectal polyps or CRC.
Thus, the results of different research studies in different regions vary significantly. Therefore,
the present study investigated the relationship between gastric H. pylori infection, and atrophy
gastritis with colorectal polyps and answers to questions regarding the necessity for colonoscopy
screening in patients with gastric H. pylori infection in China. For the research method, the
retrospective study was conducted on 792 patients with 332 (AG) and 385 (48,7%) colorectal
polyps. However, there is some information that the author should make clear. Firstly, the
author needs to make clear why the author chose a sample size ( <800 Pts). In my opinion, the
prevalence of colorectal polyp is about 18,1% in the Chinese population ( according to some
research in China), but in your research, this prevalence is very high (2,5 times), and you need
to explain the reason. Secondly, the author should be analyzed the characteristics of a polyp.
For example, the prevalence of hyperplastic polyps, adenomatous, or hamartomatous polyps.
We know that hyperplastic polyps are very common but have a very low malignant potential. In
addition, in table2 There was no statistically significant difference between adenomas with AG
and non-AG (p=0.09) meanwhile, adenomas polyps in the colon are at high risk of CRC. Finally,
the AUC of AG and H.p infection for colorectal polyp are 0,62 and 0,57 respectively. The value
is low and not enough accurate to identify the relative between AG with the colorectal polyp.
To sum up, there is some information the author needs to make clear before the conclusion
Title: Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk
factor of colorectal polyps: a retrospective study in China
Version: 2 Date: 19 Dec 2022
Reviewer:  Tran Tien Dao
Reviewer's report:
Recent trends have identified an increasing number of individuals with rectal and colon cancers.
However, it is difficult to detect CRC early due to the lack of typical clinical symptoms.
Colorectal adenomatous polyps are the most important precancerous lesions, developing into
CRC through the adenomatous cancer sequence. Therefore, early screening and detection of
precancerous lesions can prevent the occurrence and development of CRC. Gastric Helicobacter
pylori and the chronic inflammatory state caused by H. pylori infection are closely related to
the occurrence of gastric cancer. Besides, previous studies have indicated that gastric H. pylori
infection increased the risk of colorectal tumors. In contrast, however, several other reports have
concluded that gastric H. pylori infection was not correlated with colorectal polyps or CRC.
Thus, the results of different research studies in different regions vary significantly. Therefore,
the present study investigated the relationship between gastric H. pylori infection, and atrophy
gastritis with colorectal polyps and answers to questions regarding the necessity for colonoscopy
screening in patients with gastric H. pylori infection in China. For the research method, the
retrospective study was conducted on 792 patients with 332 (AG) and 385 (48,7%) colorectal
polyps. However, there is some information that the author should make clear. Firstly, the
author needs to make clear why the author chose a sample size ( <800 Pts). In my opinion, the
prevalence of colorectal polyp is about 18,1% in the Chinese population ( according to some
research in China), but in your research, this prevalence is very high (2,5 times), and you need
to explain the reason. Secondly, the author should be analyzed the characteristics of a polyp.
For example, the prevalence of hyperplastic polyps, adenomatous, or hamartomatous polyps.
We know that hyperplastic polyps are very common but have a very low malignant potential. In
addition, in table2 There was no statistically significant difference between adenomas with AG
and non-AG (p=0.09) meanwhile, adenomas polyps in the colon are at high risk of CRC. Finally,
the AUC of AG and H.p infection for colorectal polyp are 0,62 and 0,57 respectively. The value
is low and not enough accurate to identify the relative between AG with the colorectal polyp.
To sum up, there is some information the author needs to make clear before the conclusion
Please review this paper.
user
Title: Atrophic gastritis rather than Helicobacter pylori infection can be an independent risk
factor of colorectal polyps: a retrospective study in China
Version: 2 Date: 19 Dec 2022
Reviewer:  Tran Tien Dao
Reviewer's report:
Recent trends have identified an increasing number of individuals with rectal and colon cancers.
However, it is difficult to detect CRC early due to the lack of typical clinical symptoms.
Colorectal adenomatous polyps are the most important precancerous lesions, developing into
CRC through the adenomatous cancer sequence. Therefore, early screening and detection of
precancerous lesions can prevent the occurrence and development of CRC. Gastric Helicobacter
pylori and the chronic inflammatory state caused by H. pylori infection are closely related to
the occurrence of gastric cancer. Besides, previous studies have indicated that gastric H. pylori
infection increased the risk of colorectal tumors. In contrast, however, several other reports have
concluded that gastric H. pylori infection was not correlated with colorectal polyps or CRC.
Thus, the results of different research studies in different regions vary significantly. Therefore,
the present study investigated the relationship between gastric H. pylori infection, and atrophy
gastritis with colorectal polyps and answers to questions regarding the necessity for colonoscopy
screening in patients with gastric H. pylori infection in China. For the research method, the
retrospective study was conducted on 792 patients with 332 (AG) and 385 (48,7%) colorectal
polyps. However, there is some information that the author should make clear. Firstly, the
author needs to make clear why the author chose a sample size ( <800 Pts). In my opinion, the
prevalence of colorectal polyp is about 18,1% in the Chinese population ( according to some
research in China), but in your research, this prevalence is very high (2,5 times), and you need
to explain the reason. Secondly, the author should be analyzed the characteristics of a polyp.
For example, the prevalence of hyperplastic polyps, adenomatous, or hamartomatous polyps.
We know that hyperplastic polyps are very common but have a very low malignant potential. In
addition, in table2 There was no statistically significant difference between adenomas with AG
and non-AG (p=0.09) meanwhile, adenomas polyps in the colon are at high risk of CRC. Finally,
the AUC of AG and H.p infection for colorectal polyp are 0,62 and 0,57 respectively. The value
is low and not enough accurate to identify the relative between AG with the colorectal polyp.
To sum up, there is some information the author needs to make clear before the conclusion
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