Reviewer’s report
Title: 
Development and validation of a Novel Competing Risk Model for
Predicting Survival of Esophagogastric Junction Adenocarcinoma: a SEER
population-based study and external validation
Version: 
0 
Date: 
24 Apr 2020
Reviewer: 
Xingkang He
Reviewer's report:
Please include all comments for the authors in this box rather than uploading
your report as an attachment. Please only upload as attachments annotated
versions of manuscripts, graphs, supporting materials or other aspects of your
report which cannot be included in a text format.
Please overwrite this text when adding your comments to the authors.
This manuscript proveded us a novel competing risk survival predicting model
for patients with esophagogastric junction adenocarcinoma. Actually, it is not
novel and valuable for clincial practice. Several simliar papers had proposed
serveal models to predict the prognosis of patients after radiation or
esophagectomy. (1,2) Following are some suggestions and questions for the
authors to consider:
1. The authors shoud define included and excluded criteria in more detail inorder
to improve repeatability and 
reproducibility of the study. 
2. Other important therapy-related confounding should be considered, such as
surgical operation, radiation,chemthrapy. If these important factors didn't
considered in the model, the performence and valiadilty will be questioned.
Therefor I don't think that current paper is suitable for publication, major
revision should be made.
Reference 
1. Liu, F., Zhou, R., Jiang, F. et al. Proposal of a Nomogram for Predicting
Survival in Patients with Siewert Type II Adenocarcinoma of the
Esophagogastric Junction After Preoperative Radiation. Ann Surg Oncol 26,
1292-1300 (2019). https://doi.org/10.1245/s10434-019-07237-7
2. Cao, J., Yuan, P., Wang, L. et al. Clinical Nomogram for Predicting Survival
of Esophageal Cancer Patients after Esophagectomy. Sci Rep 6, 26684 (2016).
https://doi.org/10.1038/srep26684
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name
will be included on my report to the authors and, if the manuscript is accepted
for publication, my named report including any attachments I upload will be
posted on the website along with the authors' responses. I agree for my report to
be made available under an Open Access Creative Commons CC-BY license
(
http://creativecommons.org/licenses/by/4.0/
). I understand that any comments
which I do not wish to be included in my named report can be included as
confidential comments to the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’s report
Title: 
Development and validation of a Novel Competing Risk Model for
Predicting Survival of Esophagogastric Junction Adenocarcinoma: a SEER
population-based study and external validation
Version: 
0 
Date: 
24 Apr 2020
Reviewer: 
Xingkang He
Reviewer's report:
Please include all comments for the authors in this box rather than uploading
your report as an attachment. Please only upload as attachments annotated
versions of manuscripts, graphs, supporting materials or other aspects of your
report which cannot be included in a text format.
Please overwrite this text when adding your comments to the authors.
This manuscript proveded us a novel competing risk survival predicting model
for patients with esophagogastric junction adenocarcinoma. Actually, it is not
novel and valuable for clincial practice. Several simliar papers had proposed
serveal models to predict the prognosis of patients after radiation or
esophagectomy. (1,2) Following are some suggestions and questions for the
authors to consider:
1. The authors shoud define included and excluded criteria in more detail inorder
to improve repeatability and 
reproducibility of the study. 
2. Other important therapy-related confounding should be considered, such as
surgical operation, radiation,chemthrapy. If these important factors didn't
considered in the model, the performence and valiadilty will be questioned.
Therefor I don't think that current paper is suitable for publication, major
revision should be made.
Reference 
1. Liu, F., Zhou, R., Jiang, F. et al. Proposal of a Nomogram for Predicting
Survival in Patients with Siewert Type II Adenocarcinoma of the
Esophagogastric Junction After Preoperative Radiation. Ann Surg Oncol 26,
1292-1300 (2019). https://doi.org/10.1245/s10434-019-07237-7
2. Cao, J., Yuan, P., Wang, L. et al. Clinical Nomogram for Predicting Survival
of Esophageal Cancer Patients after Esophagectomy. Sci Rep 6, 26684 (2016).
https://doi.org/10.1038/srep26684
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name
will be included on my report to the authors and, if the manuscript is accepted
for publication, my named report including any attachments I upload will be
posted on the website along with the authors' responses. I agree for my report to
be made available under an Open Access Creative Commons CC-BY license
(
http://creativecommons.org/licenses/by/4.0/
). I understand that any comments
which I do not wish to be included in my named report can be included as
confidential comments to the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’s report
Title: 
Development and validation of a Novel Competing Risk Model for
Predicting Survival of Esophagogastric Junction Adenocarcinoma: a SEER
population-based study and external validation
Version: 
0 
Date: 
24 Apr 2020
Reviewer: 
Xingkang He
Reviewer's report:
Please include all comments for the authors in this box rather than uploading
your report as an attachment. Please only upload as attachments annotated
versions of manuscripts, graphs, supporting materials or other aspects of your
report which cannot be included in a text format.
Please overwrite this text when adding your comments to the authors.
This manuscript proveded us a novel competing risk survival predicting model
for patients with esophagogastric junction adenocarcinoma. Actually, it is not
novel and valuable for clincial practice. Several simliar papers had proposed
serveal models to predict the prognosis of patients after radiation or
esophagectomy. (1,2) Following are some suggestions and questions for the
authors to consider:
1. The authors shoud define included and excluded criteria in more detail inorder
to improve repeatability and 
reproducibility of the study. 
2. Other important therapy-related confounding should be considered, such as
surgical operation, radiation,chemthrapy. If these important factors didn't
considered in the model, the performence and valiadilty will be questioned.
Therefor I don't think that current paper is suitable for publication, major
revision should be made.
Reference 
1. Liu, F., Zhou, R., Jiang, F. et al. Proposal of a Nomogram for Predicting
Survival in Patients with Siewert Type II Adenocarcinoma of the
Esophagogastric Junction After Preoperative Radiation. Ann Surg Oncol 26,
1292-1300 (2019). https://doi.org/10.1245/s10434-019-07237-7
2. Cao, J., Yuan, P., Wang, L. et al. Clinical Nomogram for Predicting Survival
of Esophageal Cancer Patients after Esophagectomy. Sci Rep 6, 26684 (2016).
https://doi.org/10.1038/srep26684
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name
will be included on my report to the authors and, if the manuscript is accepted
for publication, my named report including any attachments I upload will be
posted on the website along with the authors' responses. I agree for my report to
be made available under an Open Access Creative Commons CC-BY license
(
http://creativecommons.org/licenses/by/4.0/
). I understand that any comments
which I do not wish to be included in my named report can be included as
confidential comments to the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant