Title: Using a nomogram based on the controlling nutritional status score to predict prognosis
after surgery in patients with resectable gastric cancer
Version: 0 Date: 12 Sep 2023
Reviewer's report:
In this study, researchers set out to develop a prognostic tool for predicting the overall survival
(OS) of patients with resectable gastric cancer (GC), utilizing the controlling nutritional status
(CONUT) score. The study involved a retrospective analysis of data from 404 patients who
underwent radical gastrectomy, seeking to identify significant prognostic factors for GC patients
through statistical analyses. They found that among various indicators, the CONUT score, type
of gastrectomy, pTNM stage, and nerve invasion emerged as independent risk factors for OS
following multivariate Cox regression analysis. They then constructed a nomogram based on
these factors, which exhibited a higher predictive performance (C-index of 0.76) compared
to the AJCC-8 staging system. This nomogram is poised to play a pivotal role in tailoring
postoperative therapy regimens for GC patients, offering valuable insights into their survival
outcomes. Anyway, since it is an interesting topic, I do not agree with the latest point of
methodological sequence: the CONUT does not include the history of cancer disease as well as
disease burden, so I recommend to delete the comparison between the CONUT and TNM since
they are based on completely different hypotheses. Furthermore, CONUT could empower TNM
in defining prognosis, but of course it will be described in an alternative way.
Title: Using a nomogram based on the controlling nutritional status score to predict prognosis
after surgery in patients with resectable gastric cancer
Version: 0 Date: 12 Sep 2023
Reviewer's report:
In this study, researchers set out to develop a prognostic tool for predicting the overall survival
(OS) of patients with resectable gastric cancer (GC), utilizing the controlling nutritional status
(CONUT) score. The study involved a retrospective analysis of data from 404 patients who
underwent radical gastrectomy, seeking to identify significant prognostic factors for GC patients
through statistical analyses. They found that among various indicators, the CONUT score, type
of gastrectomy, pTNM stage, and nerve invasion emerged as independent risk factors for OS
following multivariate Cox regression analysis. They then constructed a nomogram based on
these factors, which exhibited a higher predictive performance (C-index of 0.76) compared
to the AJCC-8 staging system. This nomogram is poised to play a pivotal role in tailoring
postoperative therapy regimens for GC patients, offering valuable insights into their survival
outcomes. Anyway, since it is an interesting topic, I do not agree with the latest point of
methodological sequence: the CONUT does not include the history of cancer disease as well as
disease burden, so I recommend to delete the comparison between the CONUT and TNM since
they are based on completely different hypotheses. Furthermore, CONUT could empower TNM
in defining prognosis, but of course it will be described in an alternative way.
Please review this paper.
user
Title: Using a nomogram based on the controlling nutritional status score to predict prognosis
after surgery in patients with resectable gastric cancer
Version: 0 Date: 12 Sep 2023
Reviewer's report:
In this study, researchers set out to develop a prognostic tool for predicting the overall survival
(OS) of patients with resectable gastric cancer (GC), utilizing the controlling nutritional status
(CONUT) score. The study involved a retrospective analysis of data from 404 patients who
underwent radical gastrectomy, seeking to identify significant prognostic factors for GC patients
through statistical analyses. They found that among various indicators, the CONUT score, type
of gastrectomy, pTNM stage, and nerve invasion emerged as independent risk factors for OS
following multivariate Cox regression analysis. They then constructed a nomogram based on
these factors, which exhibited a higher predictive performance (C-index of 0.76) compared
to the AJCC-8 staging system. This nomogram is poised to play a pivotal role in tailoring
postoperative therapy regimens for GC patients, offering valuable insights into their survival
outcomes. Anyway, since it is an interesting topic, I do not agree with the latest point of
methodological sequence: the CONUT does not include the history of cancer disease as well as
disease burden, so I recommend to delete the comparison between the CONUT and TNM since
they are based on completely different hypotheses. Furthermore, CONUT could empower TNM
in defining prognosis, but of course it will be described in an alternative way.
assistant