Title: Poorly Differentiated Cluster Grade-A Vital Predictor for Lymph Node Metastasis and
Oncological Outcomes in Patients with T1 Colorectal Cancer: A Retrospective Study
Version: 2 Date: 30 Jun 2022
Reviewer's report:
This study shows that PDC grade is a factor that strongly reflects LNM and oncological outcome
in T1 colorectal cancer. This finding may be a criterion for deciding whether or not to perform
an additional bowel resection in patients undergoing endoscopic resection. However, I would
like to ask a few questions.
1. Although the report describes radical surgery, it does not indicate the extent to which lymph
node dissection is performed. For example, (1) How much of the intestinal tract was resected,
(2) Was lymph node dissection performed to the center with or without (CVL), (3) Is TME
performed for rectal lesions, etc.?
2.  How many patients received postoperative adjuvant chemotherapy?
3.  The type of distant metastasis is not mentioned.
4.  Whether the combination of risk factors mentioned is evaluated.
Title: Poorly Differentiated Cluster Grade-A Vital Predictor for Lymph Node Metastasis and
Oncological Outcomes in Patients with T1 Colorectal Cancer: A Retrospective Study
Version: 2 Date: 30 Jun 2022
Reviewer's report:
This study shows that PDC grade is a factor that strongly reflects LNM and oncological outcome
in T1 colorectal cancer. This finding may be a criterion for deciding whether or not to perform
an additional bowel resection in patients undergoing endoscopic resection. However, I would
like to ask a few questions.
1. Although the report describes radical surgery, it does not indicate the extent to which lymph
node dissection is performed. For example, (1) How much of the intestinal tract was resected,
(2) Was lymph node dissection performed to the center with or without (CVL), (3) Is TME
performed for rectal lesions, etc.?
2.  How many patients received postoperative adjuvant chemotherapy?
3.  The type of distant metastasis is not mentioned.
4.  Whether the combination of risk factors mentioned is evaluated.
Please review this paper.
user
Title: Poorly Differentiated Cluster Grade-A Vital Predictor for Lymph Node Metastasis and
Oncological Outcomes in Patients with T1 Colorectal Cancer: A Retrospective Study
Version: 2 Date: 30 Jun 2022
Reviewer's report:
This study shows that PDC grade is a factor that strongly reflects LNM and oncological outcome
in T1 colorectal cancer. This finding may be a criterion for deciding whether or not to perform
an additional bowel resection in patients undergoing endoscopic resection. However, I would
like to ask a few questions.
1. Although the report describes radical surgery, it does not indicate the extent to which lymph
node dissection is performed. For example, (1) How much of the intestinal tract was resected,
(2) Was lymph node dissection performed to the center with or without (CVL), (3) Is TME
performed for rectal lesions, etc.?
2.  How many patients received postoperative adjuvant chemotherapy?
3.  The type of distant metastasis is not mentioned.
4.  Whether the combination of risk factors mentioned is evaluated.
assistant