Title: Efficacy of probiotics, prebiotics, and synbiotics on liver enzymes, lipid profiles, and
inflammation in patients with non-alcoholic fatty liver disease: a systematic review and meta-
analysis of randomized controlled trials
Version: 2 Date: 03 Mar 2024
Reviewer's report:
1)Please pay attention to paragraphing appropriately in the whole text.
2) English editing, grammar checking, and academic writing rules should be highly considered.
3) Why have the authors set a time limit for searching?
4) Please change the format of the table because the numbers in it are confusing
5)Two of the articles have similar data, why are they included, one of them should be removed
6)The search for authors was not accurate and several studies were missed. Please search again
7) I suggest to re-write the conclusion to be more clear and concise. This is important.
8) All the abbreviations used in the abstract should be defined as they can be hard to follow.
9) Results were duplicated in the text and tables/figures. I suggest avoiding any duplication in
order to improve the readability of the manuscript.
10) Why random effect model used to analysis of the results and no fixed effect model?
11)This manuscript must be edited by an academic person expert in methodology/writing for
academic journals in order to describe relevant facts, remove superfluous information, and better
organize thoughts.
12)I suggest an extensive revision of the discussion with more explanation of the results of the
current study. In discussion, many factors could have influenced the results. Please also discuss
other factors.
13) I would suggest to the authors to comment either in Introduction or in Discussion some very
important papers. For instance, a most important position paper should be cited:
Effect of probiotics on liver enzymes in patients with non-alcoholic fatty liver disease: an
umbrella of systematic review and meta-analysis
Anti-obesity properties of probiotics; a considerable medical nutrition intervention: findings
from an umbrella meta-analysis
Probiotic therapy, a novel and efficient adjuvant approach to improve glycemic status: an
umbrella meta-analysis
Effects of synbiotics supplementation on anthropometric and lipid profile parameters: Finding
from an umbrella meta-analysis
Title: Efficacy of probiotics, prebiotics, and synbiotics on liver enzymes, lipid profiles, and
inflammation in patients with non-alcoholic fatty liver disease: a systematic review and meta-
analysis of randomized controlled trials
Version: 2 Date: 03 Mar 2024
Reviewer's report:
1)Please pay attention to paragraphing appropriately in the whole text.
2) English editing, grammar checking, and academic writing rules should be highly considered.
3) Why have the authors set a time limit for searching?
4) Please change the format of the table because the numbers in it are confusing
5)Two of the articles have similar data, why are they included, one of them should be removed
6)The search for authors was not accurate and several studies were missed. Please search again
7) I suggest to re-write the conclusion to be more clear and concise. This is important.
8) All the abbreviations used in the abstract should be defined as they can be hard to follow.
9) Results were duplicated in the text and tables/figures. I suggest avoiding any duplication in
order to improve the readability of the manuscript.
10) Why random effect model used to analysis of the results and no fixed effect model?
11)This manuscript must be edited by an academic person expert in methodology/writing for
academic journals in order to describe relevant facts, remove superfluous information, and better
organize thoughts.
12)I suggest an extensive revision of the discussion with more explanation of the results of the
current study. In discussion, many factors could have influenced the results. Please also discuss
other factors.
13) I would suggest to the authors to comment either in Introduction or in Discussion some very
important papers. For instance, a most important position paper should be cited:
Effect of probiotics on liver enzymes in patients with non-alcoholic fatty liver disease: an
umbrella of systematic review and meta-analysis
Anti-obesity properties of probiotics; a considerable medical nutrition intervention: findings
from an umbrella meta-analysis
Probiotic therapy, a novel and efficient adjuvant approach to improve glycemic status: an
umbrella meta-analysis
Effects of synbiotics supplementation on anthropometric and lipid profile parameters: Finding
from an umbrella meta-analysis
Please review this paper.
user
Title: Efficacy of probiotics, prebiotics, and synbiotics on liver enzymes, lipid profiles, and
inflammation in patients with non-alcoholic fatty liver disease: a systematic review and meta-
analysis of randomized controlled trials
Version: 2 Date: 03 Mar 2024
Reviewer's report:
1)Please pay attention to paragraphing appropriately in the whole text.
2) English editing, grammar checking, and academic writing rules should be highly considered.
3) Why have the authors set a time limit for searching?
4) Please change the format of the table because the numbers in it are confusing
5)Two of the articles have similar data, why are they included, one of them should be removed
6)The search for authors was not accurate and several studies were missed. Please search again
7) I suggest to re-write the conclusion to be more clear and concise. This is important.
8) All the abbreviations used in the abstract should be defined as they can be hard to follow.
9) Results were duplicated in the text and tables/figures. I suggest avoiding any duplication in
order to improve the readability of the manuscript.
10) Why random effect model used to analysis of the results and no fixed effect model?
11)This manuscript must be edited by an academic person expert in methodology/writing for
academic journals in order to describe relevant facts, remove superfluous information, and better
organize thoughts.
12)I suggest an extensive revision of the discussion with more explanation of the results of the
current study. In discussion, many factors could have influenced the results. Please also discuss
other factors.
13) I would suggest to the authors to comment either in Introduction or in Discussion some very
important papers. For instance, a most important position paper should be cited:
Effect of probiotics on liver enzymes in patients with non-alcoholic fatty liver disease: an
umbrella of systematic review and meta-analysis
Anti-obesity properties of probiotics; a considerable medical nutrition intervention: findings
from an umbrella meta-analysis
Probiotic therapy, a novel and efficient adjuvant approach to improve glycemic status: an
umbrella meta-analysis
Effects of synbiotics supplementation on anthropometric and lipid profile parameters: Finding
from an umbrella meta-analysis
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