Reviewer’ s report
Title: Gastropathy associated with lanthanum phosphate deposition that was endoscopically
tracked for 3 years. : a case report
Version: 1Date: 30 Mar 2020
Reviewer: Yoshinobu Hirose
Reviewer's report:
The authors described a novel case regarding gastropathy associated with lanthanum phosphate
deposition that was endoscopically tracked for 3 years. Recently, the gastropathy in dialysedpatients with administration of lanthanum has been reported more often. However, the trackingdata of endoscopic findings on an individual patient basis has not been shown so far, according tothe the authors' comment. This case report has some significance, although several major problemsshould be resolved before publication.
Comments:
1. Case Presentation; a more detailed description of the treatment received by the patient is
required, particularly the dose, frequency, or medication adherence of lanthanum carbonate.
2. Page 7, Line 2; since lanthanum carbonate is a drug that is taken orally, the phrase "the drug is
excreted into feces via bile" appears to be insignificant.
3. Page 7, Line 2 from the bottom - Page 8 Line 2; I think that the sentence "These studies have
shown that alterations in tight junction proteins, including claudins, in intestinal metaplasiaassociated with lanthanum deposition increase epithelial paracellular permeability (Page, lines )" isoverstated. These studies (references 1,6,7) have just speculated on the basis of the observation,but not shown the phenomena.
4. Page 8; the second paragraph of the Discussion section is not well-written. From a logical point
of view, it is not so clear. I therefore suggest a thorough revision of the paragraph.
5. The image of figure 2c is out of focus.Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Unable to assessDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assessAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interestsI agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’ s report
Title: Gastropathy associated with lanthanum phosphate deposition that was endoscopically
tracked for 3 years. : a case report
Version: 1Date: 30 Mar 2020
Reviewer: Yoshinobu Hirose
Reviewer's report:
The authors described a novel case regarding gastropathy associated with lanthanum phosphate
deposition that was endoscopically tracked for 3 years. Recently, the gastropathy in dialysedpatients with administration of lanthanum has been reported more often. However, the trackingdata of endoscopic findings on an individual patient basis has not been shown so far, according tothe the authors' comment. This case report has some significance, although several major problemsshould be resolved before publication.
Comments:
1. Case Presentation; a more detailed description of the treatment received by the patient is
required, particularly the dose, frequency, or medication adherence of lanthanum carbonate.
2. Page 7, Line 2; since lanthanum carbonate is a drug that is taken orally, the phrase "the drug is
excreted into feces via bile" appears to be insignificant.
3. Page 7, Line 2 from the bottom - Page 8 Line 2; I think that the sentence "These studies have
shown that alterations in tight junction proteins, including claudins, in intestinal metaplasiaassociated with lanthanum deposition increase epithelial paracellular permeability (Page, lines )" isoverstated. These studies (references 1,6,7) have just speculated on the basis of the observation,but not shown the phenomena.
4. Page 8; the second paragraph of the Discussion section is not well-written. From a logical point
of view, it is not so clear. I therefore suggest a thorough revision of the paragraph.
5. The image of figure 2c is out of focus.Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Unable to assessDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assessAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interestsI agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’ s report
Title: Gastropathy associated with lanthanum phosphate deposition that was endoscopically
tracked for 3 years. : a case report
Version: 1Date: 30 Mar 2020
Reviewer: Yoshinobu Hirose
Reviewer's report:
The authors described a novel case regarding gastropathy associated with lanthanum phosphate
deposition that was endoscopically tracked for 3 years. Recently, the gastropathy in dialysedpatients with administration of lanthanum has been reported more often. However, the trackingdata of endoscopic findings on an individual patient basis has not been shown so far, according tothe the authors' comment. This case report has some significance, although several major problemsshould be resolved before publication.
Comments:
1. Case Presentation; a more detailed description of the treatment received by the patient is
required, particularly the dose, frequency, or medication adherence of lanthanum carbonate.
2. Page 7, Line 2; since lanthanum carbonate is a drug that is taken orally, the phrase "the drug is
excreted into feces via bile" appears to be insignificant.
3. Page 7, Line 2 from the bottom - Page 8 Line 2; I think that the sentence "These studies have
shown that alterations in tight junction proteins, including claudins, in intestinal metaplasiaassociated with lanthanum deposition increase epithelial paracellular permeability (Page, lines )" isoverstated. These studies (references 1,6,7) have just speculated on the basis of the observation,but not shown the phenomena.
4. Page 8; the second paragraph of the Discussion section is not well-written. From a logical point
of view, it is not so clear. I therefore suggest a thorough revision of the paragraph.
5. The image of figure 2c is out of focus.Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Unable to assessDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Unable to assessAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?
If an additional statistical review is recommended, please specify what aspects require further
assessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interestsI agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named report
including any attachments I upload will be posted on the website along with the authors'
responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant