Reviewer’s report
Title: 
Age and pain score before gastrointestinal endoscopies in children are
predictors for post procedure pain.
Version: 
0 
Date: 
11 May 2020
Reviewer: 
Craig Friesen
Reviewer's report:
This is a well-designed study on a topic of interest. Pain control around
procedures in children has become a hot topic with very little data to drive pre-
procedural assessment of post-procedure risk. In that the goal of the study was to
determine factors predictive of post-procedure pain, the manuscript is
publishable in its current form. That being said, there are two items that I think
would add to the manuscript if addressed by the authors:
1. Were there differences in the levels of pain between the pre-procedure and
post-procedure assessments? In patients with abdominal pain, it would be of
interest to know if the procedure escalated pain or whether patients simply woke
up with the same pain they were experiencing before the procedure.
2. I would like the authors to comment on what future studies should be
undertaken. They allude to assessing anxiety scores- how would they incorporate
these measures into future studies. What prospective studies would they
recommend to assess for pain or anxiety interventions?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my
report.
Reviewer’s report
Title: 
Age and pain score before gastrointestinal endoscopies in children are
predictors for post procedure pain.
Version: 
0 
Date: 
11 May 2020
Reviewer: 
Craig Friesen
Reviewer's report:
This is a well-designed study on a topic of interest. Pain control around
procedures in children has become a hot topic with very little data to drive pre-
procedural assessment of post-procedure risk. In that the goal of the study was to
determine factors predictive of post-procedure pain, the manuscript is
publishable in its current form. That being said, there are two items that I think
would add to the manuscript if addressed by the authors:
1. Were there differences in the levels of pain between the pre-procedure and
post-procedure assessments? In patients with abdominal pain, it would be of
interest to know if the procedure escalated pain or whether patients simply woke
up with the same pain they were experiencing before the procedure.
2. I would like the authors to comment on what future studies should be
undertaken. They allude to assessing anxiety scores- how would they incorporate
these measures into future studies. What prospective studies would they
recommend to assess for pain or anxiety interventions?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my
report.
Please review this paper.
user
Reviewer’s report
Title: 
Age and pain score before gastrointestinal endoscopies in children are
predictors for post procedure pain.
Version: 
0 
Date: 
11 May 2020
Reviewer: 
Craig Friesen
Reviewer's report:
This is a well-designed study on a topic of interest. Pain control around
procedures in children has become a hot topic with very little data to drive pre-
procedural assessment of post-procedure risk. In that the goal of the study was to
determine factors predictive of post-procedure pain, the manuscript is
publishable in its current form. That being said, there are two items that I think
would add to the manuscript if addressed by the authors:
1. Were there differences in the levels of pain between the pre-procedure and
post-procedure assessments? In patients with abdominal pain, it would be of
interest to know if the procedure escalated pain or whether patients simply woke
up with the same pain they were experiencing before the procedure.
2. I would like the authors to comment on what future studies should be
undertaken. They allude to assessing anxiety scores- how would they incorporate
these measures into future studies. What prospective studies would they
recommend to assess for pain or anxiety interventions?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available
under an Open Access Creative Commons CC-BY License (
http://creativecommons.org/licenses/by/4.0
) if this manuscript is accepted for
publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not
be published.
If you are not happy for us to publish this report, please contact the editorial
office before completing the review.
If you wish, you can include your name in your published report. Please note
you must decide whether to include your name at the start of the process and
confirm this decision whenever prompted. If you change your decision later, we
will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my
report.
assistant