Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 1 Date: 24 Aug 2023
Reviewer's report:
In the manuscript, the authors repeatedly address the same statements. For example, the authors
said “The association between statin use and decreased HCC risk was consistent in all subgroups
analyzed”. Please avoid repeatedly stating the same arguments with the same sentences. Similar
mistakes can be readily seen.
The authors should check the manuscript carefully. There are some inconsistent data between
text and graphs. In 50 lines of the manuscript, the authors said “Fully adjusted HR.…0.93 (95%
CI: 0.74 to 1.16) for all-cause mortality”., where the CI is not consistent with that shown in
Table 2.
In 107 lines of the manuscript, the authors sequentially listed the inclusion criteria, but there
were duplicate numbers, which the authors should carefully check.
In 153 lines of the manuscript#the authors said “We emulated a pragmatic sequence of trials…
follow-up between biological and non-biological study arms ”. What are biological and non-
biological study arms#
The authors incorrectly calculated the total number of excluded patients in Figure 1. Please
correctly indicate the number of excluded participants.
The formulation of Table 2 should be improved. Please keep the table in the same typeface as
possible.
Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 1 Date: 24 Aug 2023
Reviewer's report:
In the manuscript, the authors repeatedly address the same statements. For example, the authors
said “The association between statin use and decreased HCC risk was consistent in all subgroups
analyzed”. Please avoid repeatedly stating the same arguments with the same sentences. Similar
mistakes can be readily seen.
The authors should check the manuscript carefully. There are some inconsistent data between
text and graphs. In 50 lines of the manuscript, the authors said “Fully adjusted HR.…0.93 (95%
CI: 0.74 to 1.16) for all-cause mortality”., where the CI is not consistent with that shown in
Table 2.
In 107 lines of the manuscript, the authors sequentially listed the inclusion criteria, but there
were duplicate numbers, which the authors should carefully check.
In 153 lines of the manuscript#the authors said “We emulated a pragmatic sequence of trials…
follow-up between biological and non-biological study arms ”. What are biological and non-
biological study arms#
The authors incorrectly calculated the total number of excluded patients in Figure 1. Please
correctly indicate the number of excluded participants.
The formulation of Table 2 should be improved. Please keep the table in the same typeface as
possible.
Please review this paper.
user
Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 1 Date: 24 Aug 2023
Reviewer's report:
In the manuscript, the authors repeatedly address the same statements. For example, the authors
said “The association between statin use and decreased HCC risk was consistent in all subgroups
analyzed”. Please avoid repeatedly stating the same arguments with the same sentences. Similar
mistakes can be readily seen.
The authors should check the manuscript carefully. There are some inconsistent data between
text and graphs. In 50 lines of the manuscript, the authors said “Fully adjusted HR.…0.93 (95%
CI: 0.74 to 1.16) for all-cause mortality”., where the CI is not consistent with that shown in
Table 2.
In 107 lines of the manuscript, the authors sequentially listed the inclusion criteria, but there
were duplicate numbers, which the authors should carefully check.
In 153 lines of the manuscript#the authors said “We emulated a pragmatic sequence of trials…
follow-up between biological and non-biological study arms ”. What are biological and non-
biological study arms#
The authors incorrectly calculated the total number of excluded patients in Figure 1. Please
correctly indicate the number of excluded participants.
The formulation of Table 2 should be improved. Please keep the table in the same typeface as
possible.
assistant