Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 0 Date: 22 Jul 2024
Reviewer's report:
The main purpose of the study should be clearly added and stated in the abstract and introduction
and the study title should be changed accordingly.
Is the aim of the study the diagnostic value of 5-HIAA in diagnosing appendicitis or to
differentiate between complicated and uncomplicated appendicitis? This is not clear.
The sample size should be calculated and determined in accordance with the Power analysis
methodology for both study purposes. This is a must if the study is prospective.
Why should we use 5-HIAA to diagnose appendicitis or to differentiate between complicated
and uncomplicated appendicitis? This should also be clearly stated. Surgery is still the gold
standard after making the diagnosis. CT is also the gold standard imaging method in diagnosis
and in revealing complicated appendicitis, is there a need for 5-HIAA that increases the cost in
addition to this? You need to emphasize the need for this.
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 0 Date: 22 Jul 2024
Reviewer's report:
The main purpose of the study should be clearly added and stated in the abstract and introduction
and the study title should be changed accordingly.
Is the aim of the study the diagnostic value of 5-HIAA in diagnosing appendicitis or to
differentiate between complicated and uncomplicated appendicitis? This is not clear.
The sample size should be calculated and determined in accordance with the Power analysis
methodology for both study purposes. This is a must if the study is prospective.
Why should we use 5-HIAA to diagnose appendicitis or to differentiate between complicated
and uncomplicated appendicitis? This should also be clearly stated. Surgery is still the gold
standard after making the diagnosis. CT is also the gold standard imaging method in diagnosis
and in revealing complicated appendicitis, is there a need for 5-HIAA that increases the cost in
addition to this? You need to emphasize the need for this.
Please review this paper.
user
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 0 Date: 22 Jul 2024
Reviewer's report:
The main purpose of the study should be clearly added and stated in the abstract and introduction
and the study title should be changed accordingly.
Is the aim of the study the diagnostic value of 5-HIAA in diagnosing appendicitis or to
differentiate between complicated and uncomplicated appendicitis? This is not clear.
The sample size should be calculated and determined in accordance with the Power analysis
methodology for both study purposes. This is a must if the study is prospective.
Why should we use 5-HIAA to diagnose appendicitis or to differentiate between complicated
and uncomplicated appendicitis? This should also be clearly stated. Surgery is still the gold
standard after making the diagnosis. CT is also the gold standard imaging method in diagnosis
and in revealing complicated appendicitis, is there a need for 5-HIAA that increases the cost in
addition to this? You need to emphasize the need for this.
assistant