Reviewer's report
Title:Association between obesity and Barrett's esophagus in a Japanese
population: a hospital-based, prospective pilot study
Version: 1Date:14 July 2013
Reviewer: Anna Mokrowiecka
Reviewer's report:
Major Compulsory Revisions
1. Please, check if the definition of large WC as "more than 85 cm for men and
more than 90 cm for women" is correct? I am not sure what is Japanese
definition but in western countries these measures are usually lower in women.
Is it a mistake or it was use wrong in the statistical assessment?
Minor Essential Reviosions
2. I could not agree with the conclusions that visceral obesity were not risk factor
for ESBE, because the main measure of central obesity - WC - was higher in BE
in patients taking PPIs. It is even more important because patients with GERD
and BE are usually on PPIs.
It would be interesting to try to answer in discussion section why this association
is seen in patients on PPIs? Any practical conclusions?
2. It is very difficult to diagnose BE in patients with RE. Particularly, the
histopathological assessment of BE is impossible during esophageal
inflammation. Thus did You assess the histopahology after treatment in RE
patients, because they could not be BE any more?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Association between obesity and Barrett's esophagus in a Japanese
population: a hospital-based, prospective pilot study
Version: 1Date:14 July 2013
Reviewer: Anna Mokrowiecka
Reviewer's report:
Major Compulsory Revisions
1. Please, check if the definition of large WC as "more than 85 cm for men and
more than 90 cm for women" is correct? I am not sure what is Japanese
definition but in western countries these measures are usually lower in women.
Is it a mistake or it was use wrong in the statistical assessment?
Minor Essential Reviosions
2. I could not agree with the conclusions that visceral obesity were not risk factor
for ESBE, because the main measure of central obesity - WC - was higher in BE
in patients taking PPIs. It is even more important because patients with GERD
and BE are usually on PPIs.
It would be interesting to try to answer in discussion section why this association
is seen in patients on PPIs? Any practical conclusions?
2. It is very difficult to diagnose BE in patients with RE. Particularly, the
histopathological assessment of BE is impossible during esophageal
inflammation. Thus did You assess the histopahology after treatment in RE
patients, because they could not be BE any more?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Association between obesity and Barrett's esophagus in a Japanese
population: a hospital-based, prospective pilot study
Version: 1Date:14 July 2013
Reviewer: Anna Mokrowiecka
Reviewer's report:
Major Compulsory Revisions
1. Please, check if the definition of large WC as "more than 85 cm for men and
more than 90 cm for women" is correct? I am not sure what is Japanese
definition but in western countries these measures are usually lower in women.
Is it a mistake or it was use wrong in the statistical assessment?
Minor Essential Reviosions
2. I could not agree with the conclusions that visceral obesity were not risk factor
for ESBE, because the main measure of central obesity - WC - was higher in BE
in patients taking PPIs. It is even more important because patients with GERD
and BE are usually on PPIs.
It would be interesting to try to answer in discussion section why this association
is seen in patients on PPIs? Any practical conclusions?
2. It is very difficult to diagnose BE in patients with RE. Particularly, the
histopathological assessment of BE is impossible during esophageal
inflammation. Thus did You assess the histopahology after treatment in RE
patients, because they could not be BE any more?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
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