Title: The insoluble excretion of multi-matrix system mesalazine preparations in patients with
ulcerative colitis
Version: 6 Date: 02 Aug 2022
Reviewer:  Sakuma Takahashi
Reviewer's report:
It is my pleasure to review the manuscript entitled "The insoluble excretion of multi-matrix
system mesalazine preparations in patients with ulcerative colitis".
The manuscript has been revised well. I think this manuscript will be acceptable after some
corrections have been done.
1)  The authors write that "Although the insoluble excretion rate tended to be higher in the
left-sided colitis and extensive colitis groups, the differences among the disease types were not
statistically significant (p=0.053)." If the patients were divided into two or three group, the
insoluble excretion rate might be significantly higher in extensive colitis group.
2) Please correct the description of 20th paper of the references. I can not find the title of the
paper.
Title: The insoluble excretion of multi-matrix system mesalazine preparations in patients with
ulcerative colitis
Version: 6 Date: 02 Aug 2022
Reviewer:  Sakuma Takahashi
Reviewer's report:
It is my pleasure to review the manuscript entitled "The insoluble excretion of multi-matrix
system mesalazine preparations in patients with ulcerative colitis".
The manuscript has been revised well. I think this manuscript will be acceptable after some
corrections have been done.
1)  The authors write that "Although the insoluble excretion rate tended to be higher in the
left-sided colitis and extensive colitis groups, the differences among the disease types were not
statistically significant (p=0.053)." If the patients were divided into two or three group, the
insoluble excretion rate might be significantly higher in extensive colitis group.
2) Please correct the description of 20th paper of the references. I can not find the title of the
paper.
Please review this paper.
user
Title: The insoluble excretion of multi-matrix system mesalazine preparations in patients with
ulcerative colitis
Version: 6 Date: 02 Aug 2022
Reviewer:  Sakuma Takahashi
Reviewer's report:
It is my pleasure to review the manuscript entitled "The insoluble excretion of multi-matrix
system mesalazine preparations in patients with ulcerative colitis".
The manuscript has been revised well. I think this manuscript will be acceptable after some
corrections have been done.
1)  The authors write that "Although the insoluble excretion rate tended to be higher in the
left-sided colitis and extensive colitis groups, the differences among the disease types were not
statistically significant (p=0.053)." If the patients were divided into two or three group, the
insoluble excretion rate might be significantly higher in extensive colitis group.
2) Please correct the description of 20th paper of the references. I can not find the title of the
paper.
assistant