Title: Effectiveness and safety evaluation of terlipressin in the treatment of intestinal paralysis
in end-stage liver disease
Version: 1 Date: 27 Mar 2025
Reviewer's report:
The retrospectively and exploratorily reviewed cases represent reliable data, suggesting the
potential efficacy of terlipressin for intestinal paralysis.
However, in the prospective interventional study, treatment interventions were administered
based on patient choice, introducing a possible bias that cannot be overlooked and potentially
undermining the validity of the results.
If the study is to be positioned as an interventional trial, the design must be reconsidered using
a methodology that minimizes bias.
Title: Effectiveness and safety evaluation of terlipressin in the treatment of intestinal paralysis
in end-stage liver disease
Version: 1 Date: 27 Mar 2025
Reviewer's report:
The retrospectively and exploratorily reviewed cases represent reliable data, suggesting the
potential efficacy of terlipressin for intestinal paralysis.
However, in the prospective interventional study, treatment interventions were administered
based on patient choice, introducing a possible bias that cannot be overlooked and potentially
undermining the validity of the results.
If the study is to be positioned as an interventional trial, the design must be reconsidered using
a methodology that minimizes bias.
Please review this paper.
user
Title: Effectiveness and safety evaluation of terlipressin in the treatment of intestinal paralysis
in end-stage liver disease
Version: 1 Date: 27 Mar 2025
Reviewer's report:
The retrospectively and exploratorily reviewed cases represent reliable data, suggesting the
potential efficacy of terlipressin for intestinal paralysis.
However, in the prospective interventional study, treatment interventions were administered
based on patient choice, introducing a possible bias that cannot be overlooked and potentially
undermining the validity of the results.
If the study is to be positioned as an interventional trial, the design must be reconsidered using
a methodology that minimizes bias.
assistant