Title: Sex differences in Helicobacter pylori infection and recurrence rate among 81,754
Chinese adults: A cross-sectional study
Version: 2 Date: 05 Apr 2024
Reviewer's report:
This study aims to evaluate the prevalence of Helicobacter pylori in Gansu Province, China, and
to compare age differences between men and women in terms of HP infection rate, eradication
rate, and recurrence rate after one year.  41,751# As the authors also describe, this study can
present useful information for HP infection prevention and public health.
1. P.2 and P6. Abstract  and results
“There is a positive linear correlation between HP infection rate and age increase in women.”
Statistical analysis results show a positive correlation, but shouldn't the actual results be limited?
I think the expression be written in an age-limited manner, since at least an increase in infection
rates has not been seen after age 60?
2. P.2 Sex differences is a better keyword than sex.
3. P.5 Statistical analysis
“The variables that were statistically significant (or nearly statistically significant) by univariate
analysis were included in the multivariate logistic regression analysis.”
This is not the correct approach for the multivariate logistic regression analysis. Therefore, it
would be better to check another approach.
4. P.7 Risk factors for HP infection
Is there a correlation between age and BMI?
5. P12. The reasons for the high HP infection rate, low eradication rate, and high recurrence rate
in older females are still unclear.
What is the age of older females?
6. P12. Ohtani and Sipponen et al.
Please state reference number.
7. The sample size for each age group in Fig. 1 should be indicated.
8. Fig. 2 bar chart contains the actual number of patients. This value should be expressed as a
percentage, i.e., the total number of infected subjects in the year should be set as 100 and then
expressed as a percentage.
9. In the first place, the data in Table 1 is unnecessary because it is duplicated in Fig.
10. Please indicate page number on this manuscript.
Title: Sex differences in Helicobacter pylori infection and recurrence rate among 81,754
Chinese adults: A cross-sectional study
Version: 2 Date: 05 Apr 2024
Reviewer's report:
This study aims to evaluate the prevalence of Helicobacter pylori in Gansu Province, China, and
to compare age differences between men and women in terms of HP infection rate, eradication
rate, and recurrence rate after one year.  41,751# As the authors also describe, this study can
present useful information for HP infection prevention and public health.
1. P.2 and P6. Abstract  and results
“There is a positive linear correlation between HP infection rate and age increase in women.”
Statistical analysis results show a positive correlation, but shouldn't the actual results be limited?
I think the expression be written in an age-limited manner, since at least an increase in infection
rates has not been seen after age 60?
2. P.2 Sex differences is a better keyword than sex.
3. P.5 Statistical analysis
“The variables that were statistically significant (or nearly statistically significant) by univariate
analysis were included in the multivariate logistic regression analysis.”
This is not the correct approach for the multivariate logistic regression analysis. Therefore, it
would be better to check another approach.
4. P.7 Risk factors for HP infection
Is there a correlation between age and BMI?
5. P12. The reasons for the high HP infection rate, low eradication rate, and high recurrence rate
in older females are still unclear.
What is the age of older females?
6. P12. Ohtani and Sipponen et al.
Please state reference number.
7. The sample size for each age group in Fig. 1 should be indicated.
8. Fig. 2 bar chart contains the actual number of patients. This value should be expressed as a
percentage, i.e., the total number of infected subjects in the year should be set as 100 and then
expressed as a percentage.
9. In the first place, the data in Table 1 is unnecessary because it is duplicated in Fig.
10. Please indicate page number on this manuscript.
Please review this paper.
user
Title: Sex differences in Helicobacter pylori infection and recurrence rate among 81,754
Chinese adults: A cross-sectional study
Version: 2 Date: 05 Apr 2024
Reviewer's report:
This study aims to evaluate the prevalence of Helicobacter pylori in Gansu Province, China, and
to compare age differences between men and women in terms of HP infection rate, eradication
rate, and recurrence rate after one year.  41,751# As the authors also describe, this study can
present useful information for HP infection prevention and public health.
1. P.2 and P6. Abstract  and results
“There is a positive linear correlation between HP infection rate and age increase in women.”
Statistical analysis results show a positive correlation, but shouldn't the actual results be limited?
I think the expression be written in an age-limited manner, since at least an increase in infection
rates has not been seen after age 60?
2. P.2 Sex differences is a better keyword than sex.
3. P.5 Statistical analysis
“The variables that were statistically significant (or nearly statistically significant) by univariate
analysis were included in the multivariate logistic regression analysis.”
This is not the correct approach for the multivariate logistic regression analysis. Therefore, it
would be better to check another approach.
4. P.7 Risk factors for HP infection
Is there a correlation between age and BMI?
5. P12. The reasons for the high HP infection rate, low eradication rate, and high recurrence rate
in older females are still unclear.
What is the age of older females?
6. P12. Ohtani and Sipponen et al.
Please state reference number.
7. The sample size for each age group in Fig. 1 should be indicated.
8. Fig. 2 bar chart contains the actual number of patients. This value should be expressed as a
percentage, i.e., the total number of infected subjects in the year should be set as 100 and then
expressed as a percentage.
9. In the first place, the data in Table 1 is unnecessary because it is duplicated in Fig.
10. Please indicate page number on this manuscript.
assistant