Reviewer's report
Title:Hepatitis B Virus Inhibition in Mice by Lentiviral Vector Mediated Small
Interference RNA
Version: 2Date:17 August 2009
Reviewer: Anja Ehrhardt
Reviewer's report:
The authors made several changes to the manuscript and included a figure
showing GFP expression in liver tissue after injection of lentiviral vectors. They
also explained the rational for using hydrodynamic delivery of lentiviral vectors.
Overall, they improved the manuscript and I would support publication. There is
only one minor issue which needs further clarification:
The author show that they detected GFP expression in murine liver after
lentivirus injection. Maybe I missed that information but I am assuming that Deng
et al. used hydrodynamic delivery of lentiviral vectors for experiments shown in
Fig 2. This should be clearly stated in the Materials and Methods section and in
the respective figure legend.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Hepatitis B Virus Inhibition in Mice by Lentiviral Vector Mediated Small
Interference RNA
Version: 2Date:17 August 2009
Reviewer: Anja Ehrhardt
Reviewer's report:
The authors made several changes to the manuscript and included a figure
showing GFP expression in liver tissue after injection of lentiviral vectors. They
also explained the rational for using hydrodynamic delivery of lentiviral vectors.
Overall, they improved the manuscript and I would support publication. There is
only one minor issue which needs further clarification:
The author show that they detected GFP expression in murine liver after
lentivirus injection. Maybe I missed that information but I am assuming that Deng
et al. used hydrodynamic delivery of lentiviral vectors for experiments shown in
Fig 2. This should be clearly stated in the Materials and Methods section and in
the respective figure legend.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Hepatitis B Virus Inhibition in Mice by Lentiviral Vector Mediated Small
Interference RNA
Version: 2Date:17 August 2009
Reviewer: Anja Ehrhardt
Reviewer's report:
The authors made several changes to the manuscript and included a figure
showing GFP expression in liver tissue after injection of lentiviral vectors. They
also explained the rational for using hydrodynamic delivery of lentiviral vectors.
Overall, they improved the manuscript and I would support publication. There is
only one minor issue which needs further clarification:
The author show that they detected GFP expression in murine liver after
lentivirus injection. Maybe I missed that information but I am assuming that Deng
et al. used hydrodynamic delivery of lentiviral vectors for experiments shown in
Fig 2. This should be clearly stated in the Materials and Methods section and in
the respective figure legend.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant