Title: Association between non-insulin-based insulin resistance surrogate makers and
Helicobacter pylori infection: a population-based study
Version: 0 Date: 16 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the authors describe the statistical models in detail, they could provide more justification
for their choices. For example, why were three progressive models chosen for adjustment? How
were potential interactions handled in the analysis? A brief rationale for the modeling decisions
would improve the robustness of the methods section.
-The study categorizes the IR markers (TyG index, TG/HDL-C ratio, METS-IR) into quartiles,
which could limit the sensitivity of detecting associations. The authors mention that the IR
markers are analyzed as continuous variables as well, but it would be helpful to emphasize how
the continuous analysis complements the quartile-based approach. Including a discussion on the
advantages and limitations of using quartiles would strengthen this section.
-The discussion presents some contradictions without fully exploring them. For example, the
study mentions that H. pylori infection is associated with higher triglycerides, FBG, and IR
(consistent with the findings of Upala et al. in 2016), but it also notes that another meta-analysis
by Upala et al. in 2017 suggested that H. pylori eradication does not improve IR. The authors
could clarify these contradictions further. How can the eradication of H. pylori not improve IR
when the infection is associated with increased IR? Further discussion of potential reasons for
these conflicting findings would enrich the discussion.
-The study suggests that IR could influence the risk of H. pylori infection, which is an interesting
hypothesis. However, the authors only briefly mention this and do not provide enough evidence
or discussion to substantiate the claim. Since the study does not explore the effects of IR on H.
pylori infection directly, more caution in presenting this as "new evidence" would be prudent.
While this is a valuable hypothesis, it requires more investigation before being presented as a
strong conclusion.
Title: Association between non-insulin-based insulin resistance surrogate makers and
Helicobacter pylori infection: a population-based study
Version: 0 Date: 16 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the authors describe the statistical models in detail, they could provide more justification
for their choices. For example, why were three progressive models chosen for adjustment? How
were potential interactions handled in the analysis? A brief rationale for the modeling decisions
would improve the robustness of the methods section.
-The study categorizes the IR markers (TyG index, TG/HDL-C ratio, METS-IR) into quartiles,
which could limit the sensitivity of detecting associations. The authors mention that the IR
markers are analyzed as continuous variables as well, but it would be helpful to emphasize how
the continuous analysis complements the quartile-based approach. Including a discussion on the
advantages and limitations of using quartiles would strengthen this section.
-The discussion presents some contradictions without fully exploring them. For example, the
study mentions that H. pylori infection is associated with higher triglycerides, FBG, and IR
(consistent with the findings of Upala et al. in 2016), but it also notes that another meta-analysis
by Upala et al. in 2017 suggested that H. pylori eradication does not improve IR. The authors
could clarify these contradictions further. How can the eradication of H. pylori not improve IR
when the infection is associated with increased IR? Further discussion of potential reasons for
these conflicting findings would enrich the discussion.
-The study suggests that IR could influence the risk of H. pylori infection, which is an interesting
hypothesis. However, the authors only briefly mention this and do not provide enough evidence
or discussion to substantiate the claim. Since the study does not explore the effects of IR on H.
pylori infection directly, more caution in presenting this as "new evidence" would be prudent.
While this is a valuable hypothesis, it requires more investigation before being presented as a
strong conclusion.
Please review this paper.
user
Title: Association between non-insulin-based insulin resistance surrogate makers and
Helicobacter pylori infection: a population-based study
Version: 0 Date: 16 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the authors describe the statistical models in detail, they could provide more justification
for their choices. For example, why were three progressive models chosen for adjustment? How
were potential interactions handled in the analysis? A brief rationale for the modeling decisions
would improve the robustness of the methods section.
-The study categorizes the IR markers (TyG index, TG/HDL-C ratio, METS-IR) into quartiles,
which could limit the sensitivity of detecting associations. The authors mention that the IR
markers are analyzed as continuous variables as well, but it would be helpful to emphasize how
the continuous analysis complements the quartile-based approach. Including a discussion on the
advantages and limitations of using quartiles would strengthen this section.
-The discussion presents some contradictions without fully exploring them. For example, the
study mentions that H. pylori infection is associated with higher triglycerides, FBG, and IR
(consistent with the findings of Upala et al. in 2016), but it also notes that another meta-analysis
by Upala et al. in 2017 suggested that H. pylori eradication does not improve IR. The authors
could clarify these contradictions further. How can the eradication of H. pylori not improve IR
when the infection is associated with increased IR? Further discussion of potential reasons for
these conflicting findings would enrich the discussion.
-The study suggests that IR could influence the risk of H. pylori infection, which is an interesting
hypothesis. However, the authors only briefly mention this and do not provide enough evidence
or discussion to substantiate the claim. Since the study does not explore the effects of IR on H.
pylori infection directly, more caution in presenting this as "new evidence" would be prudent.
While this is a valuable hypothesis, it requires more investigation before being presented as a
strong conclusion.
assistant