Title: Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal
cancer: a systematic review and meta-analysis
Version: 0 Date: 27 Apr 2021
Reviewer's report:
The manuscript addresses a clear hypothesis and it would provide valuable data if the text was
better written. There are many typographical errors and incomprehensible parts of the text that
should be rewritten.
Major issues:
The term "mutation" used throughout the manuscript is confusing for readers. If this term refers
to any change in sequence, then their consequences should be considered by the authors in the
context of results interpretation. If the term refers to pathogenic variants only, then it should be
clarified throughout the manuscript.
The term "activating mutations" is not suitable for a tumor suppressor gene that is inactivated
in cancer (page 2 line 2).
The abstract states that 10 studies were included, while the text of the manuscript indicates 9?
The figures are mislabeled (1-7 or 1-4?).
There are typographical errors (page 3 line 1 and page 9 line 2).
I would suggest English proofreading.
Title: Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal
cancer: a systematic review and meta-analysis
Version: 0 Date: 27 Apr 2021
Reviewer's report:
The manuscript addresses a clear hypothesis and it would provide valuable data if the text was
better written. There are many typographical errors and incomprehensible parts of the text that
should be rewritten.
Major issues:
The term "mutation" used throughout the manuscript is confusing for readers. If this term refers
to any change in sequence, then their consequences should be considered by the authors in the
context of results interpretation. If the term refers to pathogenic variants only, then it should be
clarified throughout the manuscript.
The term "activating mutations" is not suitable for a tumor suppressor gene that is inactivated
in cancer (page 2 line 2).
The abstract states that 10 studies were included, while the text of the manuscript indicates 9?
The figures are mislabeled (1-7 or 1-4?).
There are typographical errors (page 3 line 1 and page 9 line 2).
I would suggest English proofreading.
Please review this paper.
user
Title: Prognostic role and clinicopathological features of SMAD4 gene mutation in colorectal
cancer: a systematic review and meta-analysis
Version: 0 Date: 27 Apr 2021
Reviewer's report:
The manuscript addresses a clear hypothesis and it would provide valuable data if the text was
better written. There are many typographical errors and incomprehensible parts of the text that
should be rewritten.
Major issues:
The term "mutation" used throughout the manuscript is confusing for readers. If this term refers
to any change in sequence, then their consequences should be considered by the authors in the
context of results interpretation. If the term refers to pathogenic variants only, then it should be
clarified throughout the manuscript.
The term "activating mutations" is not suitable for a tumor suppressor gene that is inactivated
in cancer (page 2 line 2).
The abstract states that 10 studies were included, while the text of the manuscript indicates 9?
The figures are mislabeled (1-7 or 1-4?).
There are typographical errors (page 3 line 1 and page 9 line 2).
I would suggest English proofreading.
assistant