Title: Evaluation of Post-market Adverse Events of Lubiprostone: A Real-World Adverse Event
Analysis from the FAERS Database
Version: 4 Date: 23 Apr 2025
Reviewer's report:
I would like to thank the authors for their thoughtful and comprehensive revisions. The
manuscript has been significantly improved in both clarity and content. The authors have
adequately addressed the previous concerns, particularly with respect to the limitations of the
FAERS database, the methodology for signal detection, and the contextualization of novel
findings within the broader literature.
The expanded discussion now appropriately frames the findings as hypothesis-generating rather
than conclusive, and the added detail on data cleaning and signal validation enhances the
transparency and robustness of the analysis. Language and formatting have also been improved
throughout.
Given the strength of the revisions and the overall quality of the work, I now find the manuscript
suitable for publication.
Title: Evaluation of Post-market Adverse Events of Lubiprostone: A Real-World Adverse Event
Analysis from the FAERS Database
Version: 4 Date: 23 Apr 2025
Reviewer's report:
I would like to thank the authors for their thoughtful and comprehensive revisions. The
manuscript has been significantly improved in both clarity and content. The authors have
adequately addressed the previous concerns, particularly with respect to the limitations of the
FAERS database, the methodology for signal detection, and the contextualization of novel
findings within the broader literature.
The expanded discussion now appropriately frames the findings as hypothesis-generating rather
than conclusive, and the added detail on data cleaning and signal validation enhances the
transparency and robustness of the analysis. Language and formatting have also been improved
throughout.
Given the strength of the revisions and the overall quality of the work, I now find the manuscript
suitable for publication.
Please review this paper.
user
Title: Evaluation of Post-market Adverse Events of Lubiprostone: A Real-World Adverse Event
Analysis from the FAERS Database
Version: 4 Date: 23 Apr 2025
Reviewer's report:
I would like to thank the authors for their thoughtful and comprehensive revisions. The
manuscript has been significantly improved in both clarity and content. The authors have
adequately addressed the previous concerns, particularly with respect to the limitations of the
FAERS database, the methodology for signal detection, and the contextualization of novel
findings within the broader literature.
The expanded discussion now appropriately frames the findings as hypothesis-generating rather
than conclusive, and the added detail on data cleaning and signal validation enhances the
transparency and robustness of the analysis. Language and formatting have also been improved
throughout.
Given the strength of the revisions and the overall quality of the work, I now find the manuscript
suitable for publication.
assistant