Reviewer's report
Title:Differences in the genetic alterations between Vietnamese and Japanese
colorectal cancers
Version:3Date:7 September 2014
Reviewer: Rashmi Prasad
Reviewer's report:
This study highlights the differences in K-ras, mtDNA and high-frequency
microsatellite instability mutation frequencies between Vietnamese and Japanese
CRC patients. Environment, especially diet could have a high impact on age of
onset and could vary in the span of a decade.
While the low number of samples could result in a sampling bias, this issue has
been addressed.
Minor Essential Revisions
A better Figure for B and C is recommended.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Differences in the genetic alterations between Vietnamese and Japanese
colorectal cancers
Version:3Date:7 September 2014
Reviewer: Rashmi Prasad
Reviewer's report:
This study highlights the differences in K-ras, mtDNA and high-frequency
microsatellite instability mutation frequencies between Vietnamese and Japanese
CRC patients. Environment, especially diet could have a high impact on age of
onset and could vary in the span of a decade.
While the low number of samples could result in a sampling bias, this issue has
been addressed.
Minor Essential Revisions
A better Figure for B and C is recommended.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Differences in the genetic alterations between Vietnamese and Japanese
colorectal cancers
Version:3Date:7 September 2014
Reviewer: Rashmi Prasad
Reviewer's report:
This study highlights the differences in K-ras, mtDNA and high-frequency
microsatellite instability mutation frequencies between Vietnamese and Japanese
CRC patients. Environment, especially diet could have a high impact on age of
onset and could vary in the span of a decade.
While the low number of samples could result in a sampling bias, this issue has
been addressed.
Minor Essential Revisions
A better Figure for B and C is recommended.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant