Title: Mean Platelet Volume and Total White Blood Cells as Diagnostic Biomarkers for Acute
Appendicitis at Omdurman Military Hospital: A Cross-Sectional Study - 2021
Version: 3 Date: 03 Aug 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The article is very interesting and it investigates about a new way
to conduct diagnosis for acute appendicitis. The novelty of the study is about the fact that
the authors present the newest result about unconventional markers not routinely used but that
should be used in the future when the results will be confirmed by further and validated studies.
The study protocol is clear and the group study is very wide.  So the results have great impact.
The overall impression is that the study is very well conducted
The findings about the use of MCV for diagnosis of acute appendicitis are of high impact and
scientifically sound.
The paper contributes significantly in investigating about new parameters for diagnosis and
follow up of common diseases such as acute appendicitis. The results presented should be used
for further studies in order to definitely validate them.
Title: Mean Platelet Volume and Total White Blood Cells as Diagnostic Biomarkers for Acute
Appendicitis at Omdurman Military Hospital: A Cross-Sectional Study - 2021
Version: 3 Date: 03 Aug 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The article is very interesting and it investigates about a new way
to conduct diagnosis for acute appendicitis. The novelty of the study is about the fact that
the authors present the newest result about unconventional markers not routinely used but that
should be used in the future when the results will be confirmed by further and validated studies.
The study protocol is clear and the group study is very wide.  So the results have great impact.
The overall impression is that the study is very well conducted
The findings about the use of MCV for diagnosis of acute appendicitis are of high impact and
scientifically sound.
The paper contributes significantly in investigating about new parameters for diagnosis and
follow up of common diseases such as acute appendicitis. The results presented should be used
for further studies in order to definitely validate them.
Please review this paper.
user
Title: Mean Platelet Volume and Total White Blood Cells as Diagnostic Biomarkers for Acute
Appendicitis at Omdurman Military Hospital: A Cross-Sectional Study - 2021
Version: 3 Date: 03 Aug 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The article is very interesting and it investigates about a new way
to conduct diagnosis for acute appendicitis. The novelty of the study is about the fact that
the authors present the newest result about unconventional markers not routinely used but that
should be used in the future when the results will be confirmed by further and validated studies.
The study protocol is clear and the group study is very wide.  So the results have great impact.
The overall impression is that the study is very well conducted
The findings about the use of MCV for diagnosis of acute appendicitis are of high impact and
scientifically sound.
The paper contributes significantly in investigating about new parameters for diagnosis and
follow up of common diseases such as acute appendicitis. The results presented should be used
for further studies in order to definitely validate them.
assistant