Reviewer's report
Title:Helicobacter pylori infection and circulating ghrelin levels - A systematic
review
Version: 1Date:12 May 2010
Reviewer: Guillermo Ignacio Perez-Perez
Reviewer's report:
The manuscript of Nweneka & Prentice entitled "Helicobacter pylori infection and
circulating ghrelin levels- A sytematic review" reported a meta analysis of several
studies that reported ghrelin levles in H. pylori positive and negative subjects.
The main goal of this analysis was to determine whether an association exists
between ghrelin and H. pylroi and in what direction.
I noticed that the authors included all the papers that measured ghrelin butthey
never mentioned if ghrelin was measured pre- or post-meal. It is well known that
ghrelin circulating values change dramatically from fast to post meal or induced
by meal.
Perhaps most of the discrepancy in the results reported is the result of this
variations.
The authors need to make more emphasis in the methods used to assess the
circulating ghrelin
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:Helicobacter pylori infection and circulating ghrelin levels - A systematic
review
Version: 1Date:12 May 2010
Reviewer: Guillermo Ignacio Perez-Perez
Reviewer's report:
The manuscript of Nweneka & Prentice entitled "Helicobacter pylori infection and
circulating ghrelin levels- A sytematic review" reported a meta analysis of several
studies that reported ghrelin levles in H. pylori positive and negative subjects.
The main goal of this analysis was to determine whether an association exists
between ghrelin and H. pylroi and in what direction.
I noticed that the authors included all the papers that measured ghrelin butthey
never mentioned if ghrelin was measured pre- or post-meal. It is well known that
ghrelin circulating values change dramatically from fast to post meal or induced
by meal.
Perhaps most of the discrepancy in the results reported is the result of this
variations.
The authors need to make more emphasis in the methods used to assess the
circulating ghrelin
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:Helicobacter pylori infection and circulating ghrelin levels - A systematic
review
Version: 1Date:12 May 2010
Reviewer: Guillermo Ignacio Perez-Perez
Reviewer's report:
The manuscript of Nweneka & Prentice entitled "Helicobacter pylori infection and
circulating ghrelin levels- A sytematic review" reported a meta analysis of several
studies that reported ghrelin levles in H. pylori positive and negative subjects.
The main goal of this analysis was to determine whether an association exists
between ghrelin and H. pylroi and in what direction.
I noticed that the authors included all the papers that measured ghrelin butthey
never mentioned if ghrelin was measured pre- or post-meal. It is well known that
ghrelin circulating values change dramatically from fast to post meal or induced
by meal.
Perhaps most of the discrepancy in the results reported is the result of this
variations.
The authors need to make more emphasis in the methods used to assess the
circulating ghrelin
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant