Title: A novel nomogram for identifying candidates for adjuvant chemotherapy in patients with
stage IB gastric adenocarcinoma
Version: 1 Date: 25 Aug 2022
Reviewer's report:
The authors reported “A novel nomogram for identifying candidates for adjuvant chemotherapy
in patients with stage IB gastric adenocarcinoma”. The authors concluded that the prognostic
nomogram in this study presented great prediction ability for these patients.
However, there are many problems in this paper, I think.
1. The authors should present the #-coefficient value in the Tables. #-coefficient is the most
important value, with which nomogram can be constructed. X axis should be started Zero point
in each variable.
2. From the graphical viewpoint, the graphical presentation of nomogram is uncommon.
3. I think continuous variables (age) should be modeled as (3-knot) restricted cubic splines for
potential nonlinear effect.
4. The authors categorized RNE factor. Harrell’s guideline (Harrell FE. Regression Modeling
Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis.
2nd edition. New York: Springer; 2015) emphasized avoiding the categorization of continuous
variables because some categorical variables are subjective and hard to standardize and do not
contain the same amount of statistical information as continuous variables.
5. From the nomogram of CSS, chemotherapy did not seem important prognostic variables
compared to other factors.
6. Given the results of this paper, it is hard to reach the conclusion. The authors should perform
below-mentioned survival analysis. First, the authors should divide 3 groups (low, intermediate,
high) based on total points obtained by nomogram. The authors should draw Kaplan-Meier
survival curves in each risk group.
Title: A novel nomogram for identifying candidates for adjuvant chemotherapy in patients with
stage IB gastric adenocarcinoma
Version: 1 Date: 25 Aug 2022
Reviewer's report:
The authors reported “A novel nomogram for identifying candidates for adjuvant chemotherapy
in patients with stage IB gastric adenocarcinoma”. The authors concluded that the prognostic
nomogram in this study presented great prediction ability for these patients.
However, there are many problems in this paper, I think.
1. The authors should present the #-coefficient value in the Tables. #-coefficient is the most
important value, with which nomogram can be constructed. X axis should be started Zero point
in each variable.
2. From the graphical viewpoint, the graphical presentation of nomogram is uncommon.
3. I think continuous variables (age) should be modeled as (3-knot) restricted cubic splines for
potential nonlinear effect.
4. The authors categorized RNE factor. Harrell’s guideline (Harrell FE. Regression Modeling
Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis.
2nd edition. New York: Springer; 2015) emphasized avoiding the categorization of continuous
variables because some categorical variables are subjective and hard to standardize and do not
contain the same amount of statistical information as continuous variables.
5. From the nomogram of CSS, chemotherapy did not seem important prognostic variables
compared to other factors.
6. Given the results of this paper, it is hard to reach the conclusion. The authors should perform
below-mentioned survival analysis. First, the authors should divide 3 groups (low, intermediate,
high) based on total points obtained by nomogram. The authors should draw Kaplan-Meier
survival curves in each risk group.
Please review this paper.
user
Title: A novel nomogram for identifying candidates for adjuvant chemotherapy in patients with
stage IB gastric adenocarcinoma
Version: 1 Date: 25 Aug 2022
Reviewer's report:
The authors reported “A novel nomogram for identifying candidates for adjuvant chemotherapy
in patients with stage IB gastric adenocarcinoma”. The authors concluded that the prognostic
nomogram in this study presented great prediction ability for these patients.
However, there are many problems in this paper, I think.
1. The authors should present the #-coefficient value in the Tables. #-coefficient is the most
important value, with which nomogram can be constructed. X axis should be started Zero point
in each variable.
2. From the graphical viewpoint, the graphical presentation of nomogram is uncommon.
3. I think continuous variables (age) should be modeled as (3-knot) restricted cubic splines for
potential nonlinear effect.
4. The authors categorized RNE factor. Harrell’s guideline (Harrell FE. Regression Modeling
Strategies: With Applications to Linear Models, Logistic Regression, and Survival Analysis.
2nd edition. New York: Springer; 2015) emphasized avoiding the categorization of continuous
variables because some categorical variables are subjective and hard to standardize and do not
contain the same amount of statistical information as continuous variables.
5. From the nomogram of CSS, chemotherapy did not seem important prognostic variables
compared to other factors.
6. Given the results of this paper, it is hard to reach the conclusion. The authors should perform
below-mentioned survival analysis. First, the authors should divide 3 groups (low, intermediate,
high) based on total points obtained by nomogram. The authors should draw Kaplan-Meier
survival curves in each risk group.
assistant