Title: The burden of nonalcoholic steatohepatitis (NASH) in the United States
Version: 4 Date: 10 Oct 2022
Reviewer's report:
Since last review, there has not been any alteration to the initial manuscript leading me to have
the following comments.
1.  The authors use general population and then diabetes as separate comparison groups to  NASH
patients.  Why?  Why isn't this a  3 way comparison with post hoc comparisons  particularly since
a general population is included?  The way that the statistical analysis is performed presently
appears  suboptimal.
2.  The discussion should include the role of obesity in all the categories they are looking at due
to its contribution.  There is little mention in the discussion to this point and it appears largely
passed over.
Title: The burden of nonalcoholic steatohepatitis (NASH) in the United States
Version: 4 Date: 10 Oct 2022
Reviewer's report:
Since last review, there has not been any alteration to the initial manuscript leading me to have
the following comments.
1.  The authors use general population and then diabetes as separate comparison groups to  NASH
patients.  Why?  Why isn't this a  3 way comparison with post hoc comparisons  particularly since
a general population is included?  The way that the statistical analysis is performed presently
appears  suboptimal.
2.  The discussion should include the role of obesity in all the categories they are looking at due
to its contribution.  There is little mention in the discussion to this point and it appears largely
passed over.
Please review this paper.
user
Title: The burden of nonalcoholic steatohepatitis (NASH) in the United States
Version: 4 Date: 10 Oct 2022
Reviewer's report:
Since last review, there has not been any alteration to the initial manuscript leading me to have
the following comments.
1.  The authors use general population and then diabetes as separate comparison groups to  NASH
patients.  Why?  Why isn't this a  3 way comparison with post hoc comparisons  particularly since
a general population is included?  The way that the statistical analysis is performed presently
appears  suboptimal.
2.  The discussion should include the role of obesity in all the categories they are looking at due
to its contribution.  There is little mention in the discussion to this point and it appears largely
passed over.
assistant