Reviewer's report
Title:A low level of serum total testosterone is independently associated with
nonalcoholic fatty liver disease
Version: 4Date:16 May 2012
Reviewer: Andreas Geier
Reviewer's report:
Reviewer's report
Title: A low level of serum total testosterone is independently associated with
nonalcoholic fatty liver disease.
Version: 2
Date: 04 Mai
Reviewer: Andreas Geier
Comment:
Kim and coworkers present a retrospective observational cross-sectional cohort
study investigating the association of testosterone and non-alcoholic fatty liver
disease. The work amends as a first report the relationship between testosterone
levels and fatty liver disease.
Also if liver biopsy as a gold standard is lacking as a consequence of the
retrospective study design the provided data are consistent and adequately
presented.
Inclusion of females would be of great interest in further studies, but restriction to
male by the aim of the study is plausible. Differential diagnosis of increased
echogenitiy of liver in ultrasound was negligible by checking medical history in
assumed healthy individuals. Unfortunately there were obviously no possibility of
re-examination of serum samples for free testosterone level and sex-hormone
binding globuline and also CK 18.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Paper reviewed by Dr. Theodor Kudlich and Prof. Andreas Geier
Reviewer's report
Title:A low level of serum total testosterone is independently associated with
nonalcoholic fatty liver disease
Version: 4Date:16 May 2012
Reviewer: Andreas Geier
Reviewer's report:
Reviewer's report
Title: A low level of serum total testosterone is independently associated with
nonalcoholic fatty liver disease.
Version: 2
Date: 04 Mai
Reviewer: Andreas Geier
Comment:
Kim and coworkers present a retrospective observational cross-sectional cohort
study investigating the association of testosterone and non-alcoholic fatty liver
disease. The work amends as a first report the relationship between testosterone
levels and fatty liver disease.
Also if liver biopsy as a gold standard is lacking as a consequence of the
retrospective study design the provided data are consistent and adequately
presented.
Inclusion of females would be of great interest in further studies, but restriction to
male by the aim of the study is plausible. Differential diagnosis of increased
echogenitiy of liver in ultrasound was negligible by checking medical history in
assumed healthy individuals. Unfortunately there were obviously no possibility of
re-examination of serum samples for free testosterone level and sex-hormone
binding globuline and also CK 18.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Paper reviewed by Dr. Theodor Kudlich and Prof. Andreas Geier
Please review this paper.
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Reviewer's report
Title:A low level of serum total testosterone is independently associated with
nonalcoholic fatty liver disease
Version: 4Date:16 May 2012
Reviewer: Andreas Geier
Reviewer's report:
Reviewer's report
Title: A low level of serum total testosterone is independently associated with
nonalcoholic fatty liver disease.
Version: 2
Date: 04 Mai
Reviewer: Andreas Geier
Comment:
Kim and coworkers present a retrospective observational cross-sectional cohort
study investigating the association of testosterone and non-alcoholic fatty liver
disease. The work amends as a first report the relationship between testosterone
levels and fatty liver disease.
Also if liver biopsy as a gold standard is lacking as a consequence of the
retrospective study design the provided data are consistent and adequately
presented.
Inclusion of females would be of great interest in further studies, but restriction to
male by the aim of the study is plausible. Differential diagnosis of increased
echogenitiy of liver in ultrasound was negligible by checking medical history in
assumed healthy individuals. Unfortunately there were obviously no possibility of
re-examination of serum samples for free testosterone level and sex-hormone
binding globuline and also CK 18.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Paper reviewed by Dr. Theodor Kudlich and Prof. Andreas Geier
assistant