Title: Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the
fundic gland type differ between patients with and without Helicobacter pylori infection: A
retrospective observational study
Version: 1 Date: 22 Mar 2022
Reviewer's report:
Authors concluded the endoscopic features of oxyntic gland adenoma and GA-FG differed
between patients with and without H. pylori infection by examining a large number of cases and
speculated the low detectability of oxyntic gland adenoma and GA-FG in patients without H.
pylori infection owing to the non-atrophic normal mucosa. This manuscript is well-written and
very interesting, so I think it deserves to be published. However, there are some questions and
things I would like you to clarify.
1. It is desirable to make a diagnosis of H. pylori-uninfected by two or more test methods. Please
clarify in detail how a diagnosis of H. pylori-uninfected was made in this study. If H. pylori
infection status was examined using only one method, there is a risk of false negative.
2. The authors treat patients with current H. pylori infection and patients with past infection as
the same Hp group. Did the location, morphology, color, and number of lesions differ between
patients with current and past H. pylori infection?
Title: Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the
fundic gland type differ between patients with and without Helicobacter pylori infection: A
retrospective observational study
Version: 1 Date: 22 Mar 2022
Reviewer's report:
Authors concluded the endoscopic features of oxyntic gland adenoma and GA-FG differed
between patients with and without H. pylori infection by examining a large number of cases and
speculated the low detectability of oxyntic gland adenoma and GA-FG in patients without H.
pylori infection owing to the non-atrophic normal mucosa. This manuscript is well-written and
very interesting, so I think it deserves to be published. However, there are some questions and
things I would like you to clarify.
1. It is desirable to make a diagnosis of H. pylori-uninfected by two or more test methods. Please
clarify in detail how a diagnosis of H. pylori-uninfected was made in this study. If H. pylori
infection status was examined using only one method, there is a risk of false negative.
2. The authors treat patients with current H. pylori infection and patients with past infection as
the same Hp group. Did the location, morphology, color, and number of lesions differ between
patients with current and past H. pylori infection?
Please review this paper.
user
Title: Endoscopic features of oxyntic gland adenoma and gastric adenocarcinoma of the
fundic gland type differ between patients with and without Helicobacter pylori infection: A
retrospective observational study
Version: 1 Date: 22 Mar 2022
Reviewer's report:
Authors concluded the endoscopic features of oxyntic gland adenoma and GA-FG differed
between patients with and without H. pylori infection by examining a large number of cases and
speculated the low detectability of oxyntic gland adenoma and GA-FG in patients without H.
pylori infection owing to the non-atrophic normal mucosa. This manuscript is well-written and
very interesting, so I think it deserves to be published. However, there are some questions and
things I would like you to clarify.
1. It is desirable to make a diagnosis of H. pylori-uninfected by two or more test methods. Please
clarify in detail how a diagnosis of H. pylori-uninfected was made in this study. If H. pylori
infection status was examined using only one method, there is a risk of false negative.
2. The authors treat patients with current H. pylori infection and patients with past infection as
the same Hp group. Did the location, morphology, color, and number of lesions differ between
patients with current and past H. pylori infection?
assistant