Title: Predictive value of lesion morphology in rectal cancer based on MRI before surgery
Version: 2 Date: 06 Jul 2023
Reviewer's report:
This paper investigates the correlation of MRI morphology of primary tumors in rectal cancer
with EMVI, synchronous metastasis, and local recurrence. The paper conducted a series of
experiments and showed some meaningful results. The paper is well organized and presented in
a good style. The claims fully supported by the experimental data.
And I also have a few questions or advice:
1.The first of the exclusion criteria is to exclude mucinous adenocarcinoma of the rectum
because mucinous adenocarcinoma has specific biological behavior. Can you explain the impact
of this particular biological behavior on your current study that led to the exclusion?
2.Please explain why not split the data into test and validation sets which would be more reliable.
3. HRT2WI and CET1WI should be defined at the first time when they first appear in the
manuscript.
4.It would be beneficial to have pathological confirmation for peritoneal reflection invasion.
5.The preoperative evaluation of rectal cancer by MRI includes TN stages, please add the N
stage if possible.
6.This study included a subset of patients with preoperative neoadjuvant therapy, which may
alter the status of the tumor or lymph nodes, which should  be one of the limitations of the study.
Title: Predictive value of lesion morphology in rectal cancer based on MRI before surgery
Version: 2 Date: 06 Jul 2023
Reviewer's report:
This paper investigates the correlation of MRI morphology of primary tumors in rectal cancer
with EMVI, synchronous metastasis, and local recurrence. The paper conducted a series of
experiments and showed some meaningful results. The paper is well organized and presented in
a good style. The claims fully supported by the experimental data.
And I also have a few questions or advice:
1.The first of the exclusion criteria is to exclude mucinous adenocarcinoma of the rectum
because mucinous adenocarcinoma has specific biological behavior. Can you explain the impact
of this particular biological behavior on your current study that led to the exclusion?
2.Please explain why not split the data into test and validation sets which would be more reliable.
3. HRT2WI and CET1WI should be defined at the first time when they first appear in the
manuscript.
4.It would be beneficial to have pathological confirmation for peritoneal reflection invasion.
5.The preoperative evaluation of rectal cancer by MRI includes TN stages, please add the N
stage if possible.
6.This study included a subset of patients with preoperative neoadjuvant therapy, which may
alter the status of the tumor or lymph nodes, which should  be one of the limitations of the study.
Please review this paper.
user
Title: Predictive value of lesion morphology in rectal cancer based on MRI before surgery
Version: 2 Date: 06 Jul 2023
Reviewer's report:
This paper investigates the correlation of MRI morphology of primary tumors in rectal cancer
with EMVI, synchronous metastasis, and local recurrence. The paper conducted a series of
experiments and showed some meaningful results. The paper is well organized and presented in
a good style. The claims fully supported by the experimental data.
And I also have a few questions or advice:
1.The first of the exclusion criteria is to exclude mucinous adenocarcinoma of the rectum
because mucinous adenocarcinoma has specific biological behavior. Can you explain the impact
of this particular biological behavior on your current study that led to the exclusion?
2.Please explain why not split the data into test and validation sets which would be more reliable.
3. HRT2WI and CET1WI should be defined at the first time when they first appear in the
manuscript.
4.It would be beneficial to have pathological confirmation for peritoneal reflection invasion.
5.The preoperative evaluation of rectal cancer by MRI includes TN stages, please add the N
stage if possible.
6.This study included a subset of patients with preoperative neoadjuvant therapy, which may
alter the status of the tumor or lymph nodes, which should  be one of the limitations of the study.
assistant