Title: Long-term outcomes after enterostomy for very early-onset inflammatory bowel disease
with interleukin-10 signaling deficiency
Version: 2 Date: 03 Aug 2023
Reviewer's report:
This report importance of timely enterostomy. Fundamental treatment for IL-10 signaling
deficiency is hematopoietic stem cell transplantation (HSCT). However, enterostomy is also
important for better prognosis. This report will be helpful for management of peri-HSCT period.
There are some comments:
The authors adapted the significant P is <0.10, not <0.05. I think that this is not widely accepted.
As for Risk factor analysis of stoma closure, the authors wrote there is difference in multiple
intestinal lesions for the time of stoma closure. However, 95% CI is 0.37-27.77. There is no
tendency.
There are some minor points:
In Introduction, “shed light on higher quantity management for VEOIBD patient” will be higher
quality management.
In Results, the age at diagnosis was not consistent between the text and table.
As for Table 2, it is better to describe not only numbers but also %.
As for Table 3, “Number of “ in each line is busy. Simply “patients with HSCT+ stoma closure
(n) is enough.
As for Table 4, the order of groups is different between the text and table. It is better to be
consistent.
Figure 1B shows annual number of patients. However, there are no discussion about these data.
If so, this figure is not necessary.
Title: Long-term outcomes after enterostomy for very early-onset inflammatory bowel disease
with interleukin-10 signaling deficiency
Version: 2 Date: 03 Aug 2023
Reviewer's report:
This report importance of timely enterostomy. Fundamental treatment for IL-10 signaling
deficiency is hematopoietic stem cell transplantation (HSCT). However, enterostomy is also
important for better prognosis. This report will be helpful for management of peri-HSCT period.
There are some comments:
The authors adapted the significant P is <0.10, not <0.05. I think that this is not widely accepted.
As for Risk factor analysis of stoma closure, the authors wrote there is difference in multiple
intestinal lesions for the time of stoma closure. However, 95% CI is 0.37-27.77. There is no
tendency.
There are some minor points:
In Introduction, “shed light on higher quantity management for VEOIBD patient” will be higher
quality management.
In Results, the age at diagnosis was not consistent between the text and table.
As for Table 2, it is better to describe not only numbers but also %.
As for Table 3, “Number of “ in each line is busy. Simply “patients with HSCT+ stoma closure
(n) is enough.
As for Table 4, the order of groups is different between the text and table. It is better to be
consistent.
Figure 1B shows annual number of patients. However, there are no discussion about these data.
If so, this figure is not necessary.
Please review this paper.
user
Title: Long-term outcomes after enterostomy for very early-onset inflammatory bowel disease
with interleukin-10 signaling deficiency
Version: 2 Date: 03 Aug 2023
Reviewer's report:
This report importance of timely enterostomy. Fundamental treatment for IL-10 signaling
deficiency is hematopoietic stem cell transplantation (HSCT). However, enterostomy is also
important for better prognosis. This report will be helpful for management of peri-HSCT period.
There are some comments:
The authors adapted the significant P is <0.10, not <0.05. I think that this is not widely accepted.
As for Risk factor analysis of stoma closure, the authors wrote there is difference in multiple
intestinal lesions for the time of stoma closure. However, 95% CI is 0.37-27.77. There is no
tendency.
There are some minor points:
In Introduction, “shed light on higher quantity management for VEOIBD patient” will be higher
quality management.
In Results, the age at diagnosis was not consistent between the text and table.
As for Table 2, it is better to describe not only numbers but also %.
As for Table 3, “Number of “ in each line is busy. Simply “patients with HSCT+ stoma closure
(n) is enough.
As for Table 4, the order of groups is different between the text and table. It is better to be
consistent.
Figure 1B shows annual number of patients. However, there are no discussion about these data.
If so, this figure is not necessary.
assistant