Title: Clinical Characteristic and Pathogenesis of Tumor-Induced Acute Pancreatitis: A
Predictive Model
Version: 1 Date: 17 Jul 2022
Reviewer's report:
1.Tumor such as pancreatic cancer are mentioned in the background as the leading cause of
admission for AP, but no literature support is provided. Because the incidence of tumor-related
acute pancreatitis was only 2.4% in the results, it ranked low and included three causes, such as
distal bile duct (14 cases), ampulla (13 cases) and pancreas (73 cases).
2.In the methods section, the author mentions that 360 patients in the control group were
randomly selected for inclusion, but what method was used for random selection? Why not 1:3
or 1:4, please describe in detail.
3.In the epidemiology section of the results, the incidence of tumor-related AP increased
significantly in 2020 and 2021 (0.81% in 2019, 3.83% in 2020, and 2.82% in 2021), why#
4.In the epidemiology section of the results, how is diet-related AP defined (diet-related (9.5%)),
and what foods are there? Is there a cause of hypercalcemia?  What is the difference between
idiopathic AP (12.7%) and AP associated with other etiologies(0.3%)?
5.In the Baseline clinical features section, "Compared with the control group, the tumor group
was less likely to have gallstone-related episodes.", how to determine whether this AP episode
was due to tumor or gallstone.
6.9% of patients underwent EUS examination, does it mean that only 9 patients were diagnosed
by EUS-FNA, and the other 91 patients were diagnosed with tumor-related AP by surgical
pathology? How to grasp the indications for surgery? Because the early manifestations of tumor-
associated AP are not specific, imaging may not have characteristic findings.
7.How is Vascular invasion defined?
Title: Clinical Characteristic and Pathogenesis of Tumor-Induced Acute Pancreatitis: A
Predictive Model
Version: 1 Date: 17 Jul 2022
Reviewer's report:
1.Tumor such as pancreatic cancer are mentioned in the background as the leading cause of
admission for AP, but no literature support is provided. Because the incidence of tumor-related
acute pancreatitis was only 2.4% in the results, it ranked low and included three causes, such as
distal bile duct (14 cases), ampulla (13 cases) and pancreas (73 cases).
2.In the methods section, the author mentions that 360 patients in the control group were
randomly selected for inclusion, but what method was used for random selection? Why not 1:3
or 1:4, please describe in detail.
3.In the epidemiology section of the results, the incidence of tumor-related AP increased
significantly in 2020 and 2021 (0.81% in 2019, 3.83% in 2020, and 2.82% in 2021), why#
4.In the epidemiology section of the results, how is diet-related AP defined (diet-related (9.5%)),
and what foods are there? Is there a cause of hypercalcemia?  What is the difference between
idiopathic AP (12.7%) and AP associated with other etiologies(0.3%)?
5.In the Baseline clinical features section, "Compared with the control group, the tumor group
was less likely to have gallstone-related episodes.", how to determine whether this AP episode
was due to tumor or gallstone.
6.9% of patients underwent EUS examination, does it mean that only 9 patients were diagnosed
by EUS-FNA, and the other 91 patients were diagnosed with tumor-related AP by surgical
pathology? How to grasp the indications for surgery? Because the early manifestations of tumor-
associated AP are not specific, imaging may not have characteristic findings.
7.How is Vascular invasion defined?
Please review this paper.
user
Title: Clinical Characteristic and Pathogenesis of Tumor-Induced Acute Pancreatitis: A
Predictive Model
Version: 1 Date: 17 Jul 2022
Reviewer's report:
1.Tumor such as pancreatic cancer are mentioned in the background as the leading cause of
admission for AP, but no literature support is provided. Because the incidence of tumor-related
acute pancreatitis was only 2.4% in the results, it ranked low and included three causes, such as
distal bile duct (14 cases), ampulla (13 cases) and pancreas (73 cases).
2.In the methods section, the author mentions that 360 patients in the control group were
randomly selected for inclusion, but what method was used for random selection? Why not 1:3
or 1:4, please describe in detail.
3.In the epidemiology section of the results, the incidence of tumor-related AP increased
significantly in 2020 and 2021 (0.81% in 2019, 3.83% in 2020, and 2.82% in 2021), why#
4.In the epidemiology section of the results, how is diet-related AP defined (diet-related (9.5%)),
and what foods are there? Is there a cause of hypercalcemia?  What is the difference between
idiopathic AP (12.7%) and AP associated with other etiologies(0.3%)?
5.In the Baseline clinical features section, "Compared with the control group, the tumor group
was less likely to have gallstone-related episodes.", how to determine whether this AP episode
was due to tumor or gallstone.
6.9% of patients underwent EUS examination, does it mean that only 9 patients were diagnosed
by EUS-FNA, and the other 91 patients were diagnosed with tumor-related AP by surgical
pathology? How to grasp the indications for surgery? Because the early manifestations of tumor-
associated AP are not specific, imaging may not have characteristic findings.
7.How is Vascular invasion defined?
assistant