Title: Association between Dietary Inflammatory Index and Ulcerative Colitis: A Case-control
Study
Version: 3 Date: 18 Mar 2025
Reviewer's report:
The manuscript addresses an important topic and presents results that contribute to clinical
practice. I have a few questions about the methodology. The authors adjust the analyses for total
energy intake, but it is not clear whether they use the residual method to calculate daily nutrient
intake. The residual method is a common method when calculating nutrient intake. If they do use
it, they would be adjusting twice for energy. I also have a few suggestions that would improve
the manuscript.
Introduction
Page 2, lines 38-39:  This statement is a subject of some controversy; therefore, it is essential
that it be supported by references from reliable sources.
“Studies have shown that intake of a diet high in omega-3 polyunsaturated fatty acids may have
a protective effect against UC.”
Page 2, lines 57-59: I suggest making it clearer that this is a study that involves an adult
population in the objective of the study, for example.
Results
Page 4, lines 138 – 144: The same information was presented twice in the same paragraph ("...50
were in remission..." and "...remission phase (47.17%)..."), I suggest reviewing this.
Page 9, lines 164-166: I suggest moving the following sentence to the methods section on
statistical analysis.
“Adopting a more conservative statistical significance threshold, adjusted p-values were
calculated using the Benjamini Hochberg method, and the significant results were consistent
with those when unadjusted.”
Page 11, table 3: In the Niacin nutrient row, in the control column, there is the word “control”
in the middle of the table.
Title: Association between Dietary Inflammatory Index and Ulcerative Colitis: A Case-control
Study
Version: 3 Date: 18 Mar 2025
Reviewer's report:
The manuscript addresses an important topic and presents results that contribute to clinical
practice. I have a few questions about the methodology. The authors adjust the analyses for total
energy intake, but it is not clear whether they use the residual method to calculate daily nutrient
intake. The residual method is a common method when calculating nutrient intake. If they do use
it, they would be adjusting twice for energy. I also have a few suggestions that would improve
the manuscript.
Introduction
Page 2, lines 38-39:  This statement is a subject of some controversy; therefore, it is essential
that it be supported by references from reliable sources.
“Studies have shown that intake of a diet high in omega-3 polyunsaturated fatty acids may have
a protective effect against UC.”
Page 2, lines 57-59: I suggest making it clearer that this is a study that involves an adult
population in the objective of the study, for example.
Results
Page 4, lines 138 – 144: The same information was presented twice in the same paragraph ("...50
were in remission..." and "...remission phase (47.17%)..."), I suggest reviewing this.
Page 9, lines 164-166: I suggest moving the following sentence to the methods section on
statistical analysis.
“Adopting a more conservative statistical significance threshold, adjusted p-values were
calculated using the Benjamini Hochberg method, and the significant results were consistent
with those when unadjusted.”
Page 11, table 3: In the Niacin nutrient row, in the control column, there is the word “control”
in the middle of the table.
Please review this paper.
user
Title: Association between Dietary Inflammatory Index and Ulcerative Colitis: A Case-control
Study
Version: 3 Date: 18 Mar 2025
Reviewer's report:
The manuscript addresses an important topic and presents results that contribute to clinical
practice. I have a few questions about the methodology. The authors adjust the analyses for total
energy intake, but it is not clear whether they use the residual method to calculate daily nutrient
intake. The residual method is a common method when calculating nutrient intake. If they do use
it, they would be adjusting twice for energy. I also have a few suggestions that would improve
the manuscript.
Introduction
Page 2, lines 38-39:  This statement is a subject of some controversy; therefore, it is essential
that it be supported by references from reliable sources.
“Studies have shown that intake of a diet high in omega-3 polyunsaturated fatty acids may have
a protective effect against UC.”
Page 2, lines 57-59: I suggest making it clearer that this is a study that involves an adult
population in the objective of the study, for example.
Results
Page 4, lines 138 – 144: The same information was presented twice in the same paragraph ("...50
were in remission..." and "...remission phase (47.17%)..."), I suggest reviewing this.
Page 9, lines 164-166: I suggest moving the following sentence to the methods section on
statistical analysis.
“Adopting a more conservative statistical significance threshold, adjusted p-values were
calculated using the Benjamini Hochberg method, and the significant results were consistent
with those when unadjusted.”
Page 11, table 3: In the Niacin nutrient row, in the control column, there is the word “control”
in the middle of the table.
assistant