Title: Long-standing Diabetes Mellitus Increases Concomitant Pancreatic Cancer Risk in
Patients with Intraductal Papillary Mucinous Neoplasms
Version: 1 Date: 11 Jul 2022
Reviewer's report:
This paper described a retrospective cohort analysis of patients with pancreatic cysts, which
reported the finding of Long-standing Diabetes Mellitus Increases Concomitant Pancreatic
Cancer Risk in Intraductal Papillary Mucinous Neoplasms. The design of analysis of this study
was fairly straightforward with relatively large number of patients, 547 patients, although cases
with event, concomitant carcinoma, were just 14 cases. Statistical examinations seem to be
acceptable. There are some concerns as follows:
1. Classification of IPMN should follow WHO classification. IPMA may correspond to IPMN
with low-grade dysplasia, IPMC, carcinoma in situ may correspond to IPMN with high-grade
dysplasia, IPMC, invasive may correspond to IPMN with associated invasive carcinoma.
2. Describing cysts other than IPMN or SCN as “P-cyst” sounds peculiar. The classification may
be described as IPMN, SCN, and Others.
Title: Long-standing Diabetes Mellitus Increases Concomitant Pancreatic Cancer Risk in
Patients with Intraductal Papillary Mucinous Neoplasms
Version: 1 Date: 11 Jul 2022
Reviewer's report:
This paper described a retrospective cohort analysis of patients with pancreatic cysts, which
reported the finding of Long-standing Diabetes Mellitus Increases Concomitant Pancreatic
Cancer Risk in Intraductal Papillary Mucinous Neoplasms. The design of analysis of this study
was fairly straightforward with relatively large number of patients, 547 patients, although cases
with event, concomitant carcinoma, were just 14 cases. Statistical examinations seem to be
acceptable. There are some concerns as follows:
1. Classification of IPMN should follow WHO classification. IPMA may correspond to IPMN
with low-grade dysplasia, IPMC, carcinoma in situ may correspond to IPMN with high-grade
dysplasia, IPMC, invasive may correspond to IPMN with associated invasive carcinoma.
2. Describing cysts other than IPMN or SCN as “P-cyst” sounds peculiar. The classification may
be described as IPMN, SCN, and Others.
Please review this paper.
user
Title: Long-standing Diabetes Mellitus Increases Concomitant Pancreatic Cancer Risk in
Patients with Intraductal Papillary Mucinous Neoplasms
Version: 1 Date: 11 Jul 2022
Reviewer's report:
This paper described a retrospective cohort analysis of patients with pancreatic cysts, which
reported the finding of Long-standing Diabetes Mellitus Increases Concomitant Pancreatic
Cancer Risk in Intraductal Papillary Mucinous Neoplasms. The design of analysis of this study
was fairly straightforward with relatively large number of patients, 547 patients, although cases
with event, concomitant carcinoma, were just 14 cases. Statistical examinations seem to be
acceptable. There are some concerns as follows:
1. Classification of IPMN should follow WHO classification. IPMA may correspond to IPMN
with low-grade dysplasia, IPMC, carcinoma in situ may correspond to IPMN with high-grade
dysplasia, IPMC, invasive may correspond to IPMN with associated invasive carcinoma.
2. Describing cysts other than IPMN or SCN as “P-cyst” sounds peculiar. The classification may
be described as IPMN, SCN, and Others.
assistant