Title: Characterization of Primary Small Intestinal Lymphoma: A Retrospective Study Based
on Double Balloon Endoscopy
Version: 2 Date: 22 Nov 2023
Reviewer's report:
The authors conducted a retrospective study of primary small intestinal lymphoma
characteristics. Although some interesting points are acknowledged, some severe problems
exist.
Major
1. The authors noted in their results that deep ulcers and aneurysmal dilation were associated
with prognosis, emphasizing the prognosis of primary small intestinal lymphoma.
However, the Introduction is inadequate because it does not include information on the prognosis
of primary small intestinal lymphoma, including previous reports.
2. Need for more description of statistical analysis.
What methods were used to perform a multivariate analysis of factors associated with prognosis?
Was the multivariate analysis using the Cox proportional hazards model, and how were the
factors selected for multivariate analysis?
3. It is disconcerting that factors associated with prognosis in multivariate analysis have odds
ratios less than 1. Does this mean the prognosis is better if there are deep ulcers and aneurysmal
dilation?
Minor
1.  The breakdown of the 30 patients is difficult to understand. I believe it should be stated
as follows "Among them, 30 were diagnosed with SIL, including 10 (33.3%) with diffuse
large B-cell lymphoma (DLBCL), 11 (21.3%) with indolent B cell lymphoma (7 follicular
lymphoma(FL), 4  with mucosa-associated lymphoid tissue lymphoma (MALT)), 9 (27.3%)
with T-cell lymphoma (5 PTCL, 3 NK/T and 1 MEITL)."
Title: Characterization of Primary Small Intestinal Lymphoma: A Retrospective Study Based
on Double Balloon Endoscopy
Version: 2 Date: 22 Nov 2023
Reviewer's report:
The authors conducted a retrospective study of primary small intestinal lymphoma
characteristics. Although some interesting points are acknowledged, some severe problems
exist.
Major
1. The authors noted in their results that deep ulcers and aneurysmal dilation were associated
with prognosis, emphasizing the prognosis of primary small intestinal lymphoma.
However, the Introduction is inadequate because it does not include information on the prognosis
of primary small intestinal lymphoma, including previous reports.
2. Need for more description of statistical analysis.
What methods were used to perform a multivariate analysis of factors associated with prognosis?
Was the multivariate analysis using the Cox proportional hazards model, and how were the
factors selected for multivariate analysis?
3. It is disconcerting that factors associated with prognosis in multivariate analysis have odds
ratios less than 1. Does this mean the prognosis is better if there are deep ulcers and aneurysmal
dilation?
Minor
1.  The breakdown of the 30 patients is difficult to understand. I believe it should be stated
as follows "Among them, 30 were diagnosed with SIL, including 10 (33.3%) with diffuse
large B-cell lymphoma (DLBCL), 11 (21.3%) with indolent B cell lymphoma (7 follicular
lymphoma(FL), 4  with mucosa-associated lymphoid tissue lymphoma (MALT)), 9 (27.3%)
with T-cell lymphoma (5 PTCL, 3 NK/T and 1 MEITL)."
Please review this paper.
user
Title: Characterization of Primary Small Intestinal Lymphoma: A Retrospective Study Based
on Double Balloon Endoscopy
Version: 2 Date: 22 Nov 2023
Reviewer's report:
The authors conducted a retrospective study of primary small intestinal lymphoma
characteristics. Although some interesting points are acknowledged, some severe problems
exist.
Major
1. The authors noted in their results that deep ulcers and aneurysmal dilation were associated
with prognosis, emphasizing the prognosis of primary small intestinal lymphoma.
However, the Introduction is inadequate because it does not include information on the prognosis
of primary small intestinal lymphoma, including previous reports.
2. Need for more description of statistical analysis.
What methods were used to perform a multivariate analysis of factors associated with prognosis?
Was the multivariate analysis using the Cox proportional hazards model, and how were the
factors selected for multivariate analysis?
3. It is disconcerting that factors associated with prognosis in multivariate analysis have odds
ratios less than 1. Does this mean the prognosis is better if there are deep ulcers and aneurysmal
dilation?
Minor
1.  The breakdown of the 30 patients is difficult to understand. I believe it should be stated
as follows "Among them, 30 were diagnosed with SIL, including 10 (33.3%) with diffuse
large B-cell lymphoma (DLBCL), 11 (21.3%) with indolent B cell lymphoma (7 follicular
lymphoma(FL), 4  with mucosa-associated lymphoid tissue lymphoma (MALT)), 9 (27.3%)
with T-cell lymphoma (5 PTCL, 3 NK/T and 1 MEITL)."
assistant