Reviewer's report
Title:The effect of H. pylori eradication on meal-associated changes in plasma
ghrelin and leptin
Version: 1Date:23 November 2010
Reviewer: Akiko Shiotani
Reviewer's report:
Major Compulsory Revisions
The study was well designed, and the results are interesting and important,
although the previous studies have indicated the effect of H. pylori infection or
eradication on ghrelin or leptin levels. However, there are problems that should
be solved.
1. Gastric atrophy is known to be the key factor that modulates plasma
acyl-ghrelin levels. Authors did not indicate histological scores of atrophy in
Suppl Table 3. Authors should estimate histological atrophy. If it is difficult, serum
pepsinogen levels should be checked to estimate atrophy. What is active gastritis
or chronic active gastritis?
2. In Table1, values of BMI are significantly higher in the Hp-positive group than
those in –negative group. The frequency of DM was higher in the Hp-positive
group than those in –negative group. However there is no evidence confirming
that Hp infection effects on BMI before eradication. How did authors select
subjects? It is better to select the subjects matching those factors. At least
authors should discuss the difference in clinical characteristics before eradication
between the two groups.
3. Authors should also discuss about the significant change in GLP-1 and PYY
after eradication.
Reviewer's report
Title:The effect of H. pylori eradication on meal-associated changes in plasma
ghrelin and leptin
Version: 1Date:23 November 2010
Reviewer: Akiko Shiotani
Reviewer's report:
Major Compulsory Revisions
The study was well designed, and the results are interesting and important,
although the previous studies have indicated the effect of H. pylori infection or
eradication on ghrelin or leptin levels. However, there are problems that should
be solved.
1. Gastric atrophy is known to be the key factor that modulates plasma
acyl-ghrelin levels. Authors did not indicate histological scores of atrophy in
Suppl Table 3. Authors should estimate histological atrophy. If it is difficult, serum
pepsinogen levels should be checked to estimate atrophy. What is active gastritis
or chronic active gastritis?
2. In Table1, values of BMI are significantly higher in the Hp-positive group than
those in –negative group. The frequency of DM was higher in the Hp-positive
group than those in –negative group. However there is no evidence confirming
that Hp infection effects on BMI before eradication. How did authors select
subjects? It is better to select the subjects matching those factors. At least
authors should discuss the difference in clinical characteristics before eradication
between the two groups.
3. Authors should also discuss about the significant change in GLP-1 and PYY
after eradication.
Please review this paper.
user
Reviewer's report
Title:The effect of H. pylori eradication on meal-associated changes in plasma
ghrelin and leptin
Version: 1Date:23 November 2010
Reviewer: Akiko Shiotani
Reviewer's report:
Major Compulsory Revisions
The study was well designed, and the results are interesting and important,
although the previous studies have indicated the effect of H. pylori infection or
eradication on ghrelin or leptin levels. However, there are problems that should
be solved.
1. Gastric atrophy is known to be the key factor that modulates plasma
acyl-ghrelin levels. Authors did not indicate histological scores of atrophy in
Suppl Table 3. Authors should estimate histological atrophy. If it is difficult, serum
pepsinogen levels should be checked to estimate atrophy. What is active gastritis
or chronic active gastritis?
2. In Table1, values of BMI are significantly higher in the Hp-positive group than
those in –negative group. The frequency of DM was higher in the Hp-positive
group than those in –negative group. However there is no evidence confirming
that Hp infection effects on BMI before eradication. How did authors select
subjects? It is better to select the subjects matching those factors. At least
authors should discuss the difference in clinical characteristics before eradication
between the two groups.
3. Authors should also discuss about the significant change in GLP-1 and PYY
after eradication.
assistant