Reviewer's report
Title:Dietary L-Arginine Supplementation Reduces Methotrexate-Induced
Intestinal Mucosal Injury in Rat
Version: 2Date:8 December 2011
Reviewer: Daniel H. Teitelbaum
Reviewer's report:
I think this is a well-written article which nicely demonstrates a unique role for
Arginine.
A few comments.
1. would the authors comment if the protein or energy delivered in the ARG
group might influence the effects, or was this relatively small?
2. Fig 1 should have a scale (e.g. 50 um with bar showing this length) on one of
the panels
3. Fig 4 should show standard deviation or SEM
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Dietary L-Arginine Supplementation Reduces Methotrexate-Induced
Intestinal Mucosal Injury in Rat
Version: 2Date:8 December 2011
Reviewer: Daniel H. Teitelbaum
Reviewer's report:
I think this is a well-written article which nicely demonstrates a unique role for
Arginine.
A few comments.
1. would the authors comment if the protein or energy delivered in the ARG
group might influence the effects, or was this relatively small?
2. Fig 1 should have a scale (e.g. 50 um with bar showing this length) on one of
the panels
3. Fig 4 should show standard deviation or SEM
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Dietary L-Arginine Supplementation Reduces Methotrexate-Induced
Intestinal Mucosal Injury in Rat
Version: 2Date:8 December 2011
Reviewer: Daniel H. Teitelbaum
Reviewer's report:
I think this is a well-written article which nicely demonstrates a unique role for
Arginine.
A few comments.
1. would the authors comment if the protein or energy delivered in the ARG
group might influence the effects, or was this relatively small?
2. Fig 1 should have a scale (e.g. 50 um with bar showing this length) on one of
the panels
3. Fig 4 should show standard deviation or SEM
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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