Title: Title: Immediate postoperative parenteral anticoagulant therapy in patients with
mesenteric ischemia after intestinal resection – A retrospective cohort study at a single institute.
Version: 2 Date: 10 Feb 2022
Reviewer's report:
This is a retrospective study of patients with acute mesenteric infarction (AMI) and bowel
gangrene in a single center. This study aimed to elucidate the benefit of postoperative parenteral
anticoagulant in patients with AMI and intestinal resection.
The manuscript has several limitations:
The major limitation in this study was its retrospective study design and the limited number of
patients. It is difficult to draw a convincing conclusion among so many confounding factors from
85 patients. Patients without anticoagulant tended to have a more severe inflammatory response
(WBC, albumin), increased incidence of shock status and decreased hemoglobin level. These
difference may lead to different conclusion. The propensity matching analysis based on a larger
sample size may be a more appropriate statistical method.
“The patients who did not have immediate postoperative parenteral anticoagulants were
categorized into group A and those who had immediate postoperative parenteral anticoagulants
were included in group B.” Does this means patients in group A were also received enoxaparin?
The median time interval after operation for patients in group A received enoxaparin is ? This
definition of immediate postoperative parenteral anticoagulants should be explicitly stated in
material and methods.
Title: Title: Immediate postoperative parenteral anticoagulant therapy in patients with
mesenteric ischemia after intestinal resection – A retrospective cohort study at a single institute.
Version: 2 Date: 10 Feb 2022
Reviewer's report:
This is a retrospective study of patients with acute mesenteric infarction (AMI) and bowel
gangrene in a single center. This study aimed to elucidate the benefit of postoperative parenteral
anticoagulant in patients with AMI and intestinal resection.
The manuscript has several limitations:
The major limitation in this study was its retrospective study design and the limited number of
patients. It is difficult to draw a convincing conclusion among so many confounding factors from
85 patients. Patients without anticoagulant tended to have a more severe inflammatory response
(WBC, albumin), increased incidence of shock status and decreased hemoglobin level. These
difference may lead to different conclusion. The propensity matching analysis based on a larger
sample size may be a more appropriate statistical method.
“The patients who did not have immediate postoperative parenteral anticoagulants were
categorized into group A and those who had immediate postoperative parenteral anticoagulants
were included in group B.” Does this means patients in group A were also received enoxaparin?
The median time interval after operation for patients in group A received enoxaparin is ? This
definition of immediate postoperative parenteral anticoagulants should be explicitly stated in
material and methods.
Please review this paper.
user
Title: Title: Immediate postoperative parenteral anticoagulant therapy in patients with
mesenteric ischemia after intestinal resection – A retrospective cohort study at a single institute.
Version: 2 Date: 10 Feb 2022
Reviewer's report:
This is a retrospective study of patients with acute mesenteric infarction (AMI) and bowel
gangrene in a single center. This study aimed to elucidate the benefit of postoperative parenteral
anticoagulant in patients with AMI and intestinal resection.
The manuscript has several limitations:
The major limitation in this study was its retrospective study design and the limited number of
patients. It is difficult to draw a convincing conclusion among so many confounding factors from
85 patients. Patients without anticoagulant tended to have a more severe inflammatory response
(WBC, albumin), increased incidence of shock status and decreased hemoglobin level. These
difference may lead to different conclusion. The propensity matching analysis based on a larger
sample size may be a more appropriate statistical method.
“The patients who did not have immediate postoperative parenteral anticoagulants were
categorized into group A and those who had immediate postoperative parenteral anticoagulants
were included in group B.” Does this means patients in group A were also received enoxaparin?
The median time interval after operation for patients in group A received enoxaparin is ? This
definition of immediate postoperative parenteral anticoagulants should be explicitly stated in
material and methods.
assistant