Reviewer's report
Title:Microscopic polyangiitis complicated with ileal involvement detected by
double-balloon endoscopy: a case report
Version: 1Date:23 November 2012
Reviewer: Chrong-Reen Wang
Reviewer's report:
The authors reported on ileal involvement detected by double-balloon endoscopy
in microscopic polyangiitis, and they concluded that this disease should be
considered as a differential diagnosis when small intestinal changes observed by
the endoscopy such as various form of ulcers with redness and edema. This
case report is interesting and, in general, the manuscript is well written in
English. It reflects the rare presentation of small intestinal involvement in
anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and is
worthwhile to be published in BMC Gastroenterology.
However, four minor issues needed to be clarified as follows.
1.On the page 8 of Conclusion section, the authors pointed out that treatment
should be performed when the ANCA-associated vasculitis is strongly suspected
clinically even if no histological evidence of necrotizing vasculitis, and repeated
biopsy should be avoided because it can result in delayed initiation of treatment
and adverse sequelae. Therefore, the authors could consider to revise their
statement on the lines 3 to 4 of page 3 in Abstract section “Although histological
evidence of microscopic polyangiitis is important, the treatment should not be
delayed by repeating the biopsy”.
2.Since the authors performed the renal biopsy to confirm the kidney involvement
in microscopic polyangiitis, the amount of proteinuria could be expressed
quantitatively rather than ‘slight” proteinuria on the lines 17 to 18 of page 5.
3.The authors might precise their examination on ANCA on the line 16 of page 6.
The test used for the measurement of ANCA could be anti-myeloperoxidase
antibodies with 42.5 U/ml by using the enzyme-linked immunosorbent assay.
4.Wegener’s granulomatosis should be replaced with another name
“Granulomatosis with polyangiitis” in this report on the line 4 of page 4 and line 7
of page 9 (Arthritis Rheum 2011; 63: 863-4).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
The rewiewer declares no competing interests.
Reviewer's report
Title:Microscopic polyangiitis complicated with ileal involvement detected by
double-balloon endoscopy: a case report
Version: 1Date:23 November 2012
Reviewer: Chrong-Reen Wang
Reviewer's report:
The authors reported on ileal involvement detected by double-balloon endoscopy
in microscopic polyangiitis, and they concluded that this disease should be
considered as a differential diagnosis when small intestinal changes observed by
the endoscopy such as various form of ulcers with redness and edema. This
case report is interesting and, in general, the manuscript is well written in
English. It reflects the rare presentation of small intestinal involvement in
anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and is
worthwhile to be published in BMC Gastroenterology.
However, four minor issues needed to be clarified as follows.
1.On the page 8 of Conclusion section, the authors pointed out that treatment
should be performed when the ANCA-associated vasculitis is strongly suspected
clinically even if no histological evidence of necrotizing vasculitis, and repeated
biopsy should be avoided because it can result in delayed initiation of treatment
and adverse sequelae. Therefore, the authors could consider to revise their
statement on the lines 3 to 4 of page 3 in Abstract section “Although histological
evidence of microscopic polyangiitis is important, the treatment should not be
delayed by repeating the biopsy”.
2.Since the authors performed the renal biopsy to confirm the kidney involvement
in microscopic polyangiitis, the amount of proteinuria could be expressed
quantitatively rather than ‘slight” proteinuria on the lines 17 to 18 of page 5.
3.The authors might precise their examination on ANCA on the line 16 of page 6.
The test used for the measurement of ANCA could be anti-myeloperoxidase
antibodies with 42.5 U/ml by using the enzyme-linked immunosorbent assay.
4.Wegener’s granulomatosis should be replaced with another name
“Granulomatosis with polyangiitis” in this report on the line 4 of page 4 and line 7
of page 9 (Arthritis Rheum 2011; 63: 863-4).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
The rewiewer declares no competing interests.
Please review this paper.
user
Reviewer's report
Title:Microscopic polyangiitis complicated with ileal involvement detected by
double-balloon endoscopy: a case report
Version: 1Date:23 November 2012
Reviewer: Chrong-Reen Wang
Reviewer's report:
The authors reported on ileal involvement detected by double-balloon endoscopy
in microscopic polyangiitis, and they concluded that this disease should be
considered as a differential diagnosis when small intestinal changes observed by
the endoscopy such as various form of ulcers with redness and edema. This
case report is interesting and, in general, the manuscript is well written in
English. It reflects the rare presentation of small intestinal involvement in
anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis, and is
worthwhile to be published in BMC Gastroenterology.
However, four minor issues needed to be clarified as follows.
1.On the page 8 of Conclusion section, the authors pointed out that treatment
should be performed when the ANCA-associated vasculitis is strongly suspected
clinically even if no histological evidence of necrotizing vasculitis, and repeated
biopsy should be avoided because it can result in delayed initiation of treatment
and adverse sequelae. Therefore, the authors could consider to revise their
statement on the lines 3 to 4 of page 3 in Abstract section “Although histological
evidence of microscopic polyangiitis is important, the treatment should not be
delayed by repeating the biopsy”.
2.Since the authors performed the renal biopsy to confirm the kidney involvement
in microscopic polyangiitis, the amount of proteinuria could be expressed
quantitatively rather than ‘slight” proteinuria on the lines 17 to 18 of page 5.
3.The authors might precise their examination on ANCA on the line 16 of page 6.
The test used for the measurement of ANCA could be anti-myeloperoxidase
antibodies with 42.5 U/ml by using the enzyme-linked immunosorbent assay.
4.Wegener’s granulomatosis should be replaced with another name
“Granulomatosis with polyangiitis” in this report on the line 4 of page 4 and line 7
of page 9 (Arthritis Rheum 2011; 63: 863-4).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
The rewiewer declares no competing interests.
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