Reviewer's report
Title:A randomized, double-blind study of the effects of omega-3 fatty acids
(Omegaven) on outcome after major liver resection
Version:2Date:11 April 2015
Reviewer: Srinivasan Dasarathy
Reviewer's report:
This is a review of the multicenter protocol that examines the impact of 2 doses
of omega 3 fatty acid infusion in the perioperative period of a set of predefined
outcome measures.
The study is very well designed and will address the specific questions being
raised. The protocol for randomization and double blinding has been the 2
groups has taken into account all identifiable confounding factors.
The following concerns do remain
Are patients stratified for hepatic reserve- Child or MELD score when being
randomized; will a stratified randomization be adopted to overcome this
Will the indication for resection affect the outcome
Will readmission within 1m or 3 m be affected?
Will recovery of hepatic regeneration be considered as an outcome measure
Will hepatic decompensation be defined a priori?
Is the dose dependent on body weight or is a fixed dose being administered to all
subjects? Given the distribution of omega 3 fatty acids in adipose tissue, this may
impact the availability of the free omega 3 fatty acids in circulation.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:A randomized, double-blind study of the effects of omega-3 fatty acids
(Omegaven) on outcome after major liver resection
Version:2Date:11 April 2015
Reviewer: Srinivasan Dasarathy
Reviewer's report:
This is a review of the multicenter protocol that examines the impact of 2 doses
of omega 3 fatty acid infusion in the perioperative period of a set of predefined
outcome measures.
The study is very well designed and will address the specific questions being
raised. The protocol for randomization and double blinding has been the 2
groups has taken into account all identifiable confounding factors.
The following concerns do remain
Are patients stratified for hepatic reserve- Child or MELD score when being
randomized; will a stratified randomization be adopted to overcome this
Will the indication for resection affect the outcome
Will readmission within 1m or 3 m be affected?
Will recovery of hepatic regeneration be considered as an outcome measure
Will hepatic decompensation be defined a priori?
Is the dose dependent on body weight or is a fixed dose being administered to all
subjects? Given the distribution of omega 3 fatty acids in adipose tissue, this may
impact the availability of the free omega 3 fatty acids in circulation.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:A randomized, double-blind study of the effects of omega-3 fatty acids
(Omegaven) on outcome after major liver resection
Version:2Date:11 April 2015
Reviewer: Srinivasan Dasarathy
Reviewer's report:
This is a review of the multicenter protocol that examines the impact of 2 doses
of omega 3 fatty acid infusion in the perioperative period of a set of predefined
outcome measures.
The study is very well designed and will address the specific questions being
raised. The protocol for randomization and double blinding has been the 2
groups has taken into account all identifiable confounding factors.
The following concerns do remain
Are patients stratified for hepatic reserve- Child or MELD score when being
randomized; will a stratified randomization be adopted to overcome this
Will the indication for resection affect the outcome
Will readmission within 1m or 3 m be affected?
Will recovery of hepatic regeneration be considered as an outcome measure
Will hepatic decompensation be defined a priori?
Is the dose dependent on body weight or is a fixed dose being administered to all
subjects? Given the distribution of omega 3 fatty acids in adipose tissue, this may
impact the availability of the free omega 3 fatty acids in circulation.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
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