Title: Examination of the characteristics of long-term survivors among patients with gallbladder
cancer with liver metastasis who underwent surgical treatment: A retrospective multicenter study
(ACRoS1406)
Version: 3 Date: 04 Mar 2022
Reviewer:  Anup Kumar
Reviewer's report:
Very interesting paper  on role of surgery and its outcome  in advanced gallbladder cancer ( stage
III/ IV), a multicentered , though a retrospective analysis. Following are some of the comments
1. There are too many tables . Table 4 may be deleted and  put in the text at appropriate place.
2. Authors have found significance  in the  surgical out come in the period 2007–2013  as
compared to year 2000–2006 . What are the possible explanation?  ie difference surgery or better
technical support etc. The reasons should be discussed under discussion.
3. As this was a multicentered retrospective data analysis, there must be difference  in surgical
approach which varies from center to center. Was there  any  significant  difference  on survival
or recurrence  when the centers were analyzed as a factors?  Provide a separate tables  including
data from all  five centers.
4. In conclusions  authors have described "-----minimally invasive minor hepatectomy with
R0 resection -----" . What the meaning of minimally invasive? Is it laparoscopic or minor
hepatectomy?
Title: Examination of the characteristics of long-term survivors among patients with gallbladder
cancer with liver metastasis who underwent surgical treatment: A retrospective multicenter study
(ACRoS1406)
Version: 3 Date: 04 Mar 2022
Reviewer:  Anup Kumar
Reviewer's report:
Very interesting paper  on role of surgery and its outcome  in advanced gallbladder cancer ( stage
III/ IV), a multicentered , though a retrospective analysis. Following are some of the comments
1. There are too many tables . Table 4 may be deleted and  put in the text at appropriate place.
2. Authors have found significance  in the  surgical out come in the period 2007–2013  as
compared to year 2000–2006 . What are the possible explanation?  ie difference surgery or better
technical support etc. The reasons should be discussed under discussion.
3. As this was a multicentered retrospective data analysis, there must be difference  in surgical
approach which varies from center to center. Was there  any  significant  difference  on survival
or recurrence  when the centers were analyzed as a factors?  Provide a separate tables  including
data from all  five centers.
4. In conclusions  authors have described "-----minimally invasive minor hepatectomy with
R0 resection -----" . What the meaning of minimally invasive? Is it laparoscopic or minor
hepatectomy?
Please review this paper.
user
Title: Examination of the characteristics of long-term survivors among patients with gallbladder
cancer with liver metastasis who underwent surgical treatment: A retrospective multicenter study
(ACRoS1406)
Version: 3 Date: 04 Mar 2022
Reviewer:  Anup Kumar
Reviewer's report:
Very interesting paper  on role of surgery and its outcome  in advanced gallbladder cancer ( stage
III/ IV), a multicentered , though a retrospective analysis. Following are some of the comments
1. There are too many tables . Table 4 may be deleted and  put in the text at appropriate place.
2. Authors have found significance  in the  surgical out come in the period 2007–2013  as
compared to year 2000–2006 . What are the possible explanation?  ie difference surgery or better
technical support etc. The reasons should be discussed under discussion.
3. As this was a multicentered retrospective data analysis, there must be difference  in surgical
approach which varies from center to center. Was there  any  significant  difference  on survival
or recurrence  when the centers were analyzed as a factors?  Provide a separate tables  including
data from all  five centers.
4. In conclusions  authors have described "-----minimally invasive minor hepatectomy with
R0 resection -----" . What the meaning of minimally invasive? Is it laparoscopic or minor
hepatectomy?
assistant