Title: Value of transrectal ultrasound guided biopsy in endoscopy negative biopsy patients with
rectal lesions
Version: 1 Date: 15 Apr 2023
Reviewer:  Andreas Polydorou
Reviewer's report:
This study is very good and helps in better histological diagnosis of rectal tumors especially
those that are not accompanied by mucosal damage. A few points need to be clarified:
1. Selection criteria number 3 states that patients had normal preoperative examinations. This
means that they had undergone a rectal CT scan or MRI with no pathological findings or not.
2. Details of endoscopic imaging and biopsies should be reported, eg in how many patients there
was visible mucosal damage and how many biopsies were taken each time.
It is mentioned in the results that the median size of the lesions was 4.5 cm, but it is not mentioned
with which examination it was measured, eg endoscopy, CT, MRI?
3. It would be interesting to add to table 3 in separate columns the clinical diagnoses from CT,
MRI and endoscopy and maybe understand the reason for failure of CE-TRUS or TRUS.
4. A comment should be added regarding the training and experience of the physician performing
the TRUS or CE-TRUS biopsies.
Title: Value of transrectal ultrasound guided biopsy in endoscopy negative biopsy patients with
rectal lesions
Version: 1 Date: 15 Apr 2023
Reviewer:  Andreas Polydorou
Reviewer's report:
This study is very good and helps in better histological diagnosis of rectal tumors especially
those that are not accompanied by mucosal damage. A few points need to be clarified:
1. Selection criteria number 3 states that patients had normal preoperative examinations. This
means that they had undergone a rectal CT scan or MRI with no pathological findings or not.
2. Details of endoscopic imaging and biopsies should be reported, eg in how many patients there
was visible mucosal damage and how many biopsies were taken each time.
It is mentioned in the results that the median size of the lesions was 4.5 cm, but it is not mentioned
with which examination it was measured, eg endoscopy, CT, MRI?
3. It would be interesting to add to table 3 in separate columns the clinical diagnoses from CT,
MRI and endoscopy and maybe understand the reason for failure of CE-TRUS or TRUS.
4. A comment should be added regarding the training and experience of the physician performing
the TRUS or CE-TRUS biopsies.
Please review this paper.
user
Title: Value of transrectal ultrasound guided biopsy in endoscopy negative biopsy patients with
rectal lesions
Version: 1 Date: 15 Apr 2023
Reviewer:  Andreas Polydorou
Reviewer's report:
This study is very good and helps in better histological diagnosis of rectal tumors especially
those that are not accompanied by mucosal damage. A few points need to be clarified:
1. Selection criteria number 3 states that patients had normal preoperative examinations. This
means that they had undergone a rectal CT scan or MRI with no pathological findings or not.
2. Details of endoscopic imaging and biopsies should be reported, eg in how many patients there
was visible mucosal damage and how many biopsies were taken each time.
It is mentioned in the results that the median size of the lesions was 4.5 cm, but it is not mentioned
with which examination it was measured, eg endoscopy, CT, MRI?
3. It would be interesting to add to table 3 in separate columns the clinical diagnoses from CT,
MRI and endoscopy and maybe understand the reason for failure of CE-TRUS or TRUS.
4. A comment should be added regarding the training and experience of the physician performing
the TRUS or CE-TRUS biopsies.
assistant