Reviewer's report
Title:Factors affecting post-embolization fever and liver failure after trans-arterial
chemo-embolization in a cohort without background infective hepatitis- a
prospective analysis
Version:1Date:19 June 2015
Reviewer: DARIO PORETT
Reviewer's report:
MAJOR COMPULSORY REVISIONS
1. In the methodology chapter it is not stated if patients receive any type of
parenteral medication before, during and after the chemoembolization procedure.
This is a key issue for several reasons: it affects pain and nausea if pain killers
and antiemetics are used, it might have an impact on fever for the possible risk of
developing infections, especially for patients with previous interventions on the
biliary tract, if antibiotics are used.
2. In the Results the complications are correctly enumerated, but in the
discussion only PEF and AHD are taken into consideration. This is a severe lack
in the paper, especially for AKI , because it is a possible life threatening
complication. We need to know the degree of insufficiency and the way it has
been treated. It is also important to know the severity and duration of the other
complications: NV, abdominal pain and infection. The latter in particular has to be
correlated to the dimensions of the lesions treated, which is accepted as a key
element.
3. In the discussion section : - line 268 – please define how much hospital stay
was prolonged; - line 270 – what are the precautions you consider could be
useful in reducing the incidence of the complication?
As previously stated please complete with consideration on all the other
complications non discussed.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Factors affecting post-embolization fever and liver failure after trans-arterial
chemo-embolization in a cohort without background infective hepatitis- a
prospective analysis
Version:1Date:19 June 2015
Reviewer: DARIO PORETT
Reviewer's report:
MAJOR COMPULSORY REVISIONS
1. In the methodology chapter it is not stated if patients receive any type of
parenteral medication before, during and after the chemoembolization procedure.
This is a key issue for several reasons: it affects pain and nausea if pain killers
and antiemetics are used, it might have an impact on fever for the possible risk of
developing infections, especially for patients with previous interventions on the
biliary tract, if antibiotics are used.
2. In the Results the complications are correctly enumerated, but in the
discussion only PEF and AHD are taken into consideration. This is a severe lack
in the paper, especially for AKI , because it is a possible life threatening
complication. We need to know the degree of insufficiency and the way it has
been treated. It is also important to know the severity and duration of the other
complications: NV, abdominal pain and infection. The latter in particular has to be
correlated to the dimensions of the lesions treated, which is accepted as a key
element.
3. In the discussion section : - line 268 – please define how much hospital stay
was prolonged; - line 270 – what are the precautions you consider could be
useful in reducing the incidence of the complication?
As previously stated please complete with consideration on all the other
complications non discussed.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Factors affecting post-embolization fever and liver failure after trans-arterial
chemo-embolization in a cohort without background infective hepatitis- a
prospective analysis
Version:1Date:19 June 2015
Reviewer: DARIO PORETT
Reviewer's report:
MAJOR COMPULSORY REVISIONS
1. In the methodology chapter it is not stated if patients receive any type of
parenteral medication before, during and after the chemoembolization procedure.
This is a key issue for several reasons: it affects pain and nausea if pain killers
and antiemetics are used, it might have an impact on fever for the possible risk of
developing infections, especially for patients with previous interventions on the
biliary tract, if antibiotics are used.
2. In the Results the complications are correctly enumerated, but in the
discussion only PEF and AHD are taken into consideration. This is a severe lack
in the paper, especially for AKI , because it is a possible life threatening
complication. We need to know the degree of insufficiency and the way it has
been treated. It is also important to know the severity and duration of the other
complications: NV, abdominal pain and infection. The latter in particular has to be
correlated to the dimensions of the lesions treated, which is accepted as a key
element.
3. In the discussion section : - line 268 – please define how much hospital stay
was prolonged; - line 270 – what are the precautions you consider could be
useful in reducing the incidence of the complication?
As previously stated please complete with consideration on all the other
complications non discussed.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
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