Reviewer's report
Title:The relationship between irritable bowel syndrome, functional dyspepsia,
chronic fatigue and overactive bladder syndrome: A controlled study 6 years after
acute gastrointestinal infection.
Version:1Date:18 March 2015
Reviewer: Francesco Luzza
Reviewer's report:
In this study authors reported an higher prevalence of overactive bladder
syndrome (OBS) in a cohort of 724 individuals with laboratory confirmed
giardiasis six years earlier compared with 847 controls matched by gender and
sex (18.7% vs 13.6%). However, this association disappeared when other
comorbid disorders, such as irritable bowel syndrome (IBS), chronic fatigue
syndrome (CFS), and functional dyspepsia (FD), were controlled for. Indeed, the
prevalence of OAB among individuals with no comorbid IBS, CFS, and FD was
quite similar in Giardia exposed and controls (12.4% vs 10.9%). Nevertheless,
the proportion of OAB in the Giardia cohort that could have been prevented had
not individuals been exposed to Giardia was considerably lower than that for any
of the other functional disorders (27.5% vs 70.3, 64%, and 68.6% in IBS, CFS,
and FD, respectively). Authors also found that CFS and sporadic, but not
post-infectious, IBS were associated with increased risk of OAB.
The study is well written, methods are appropriate, and data well presented and
discussed. The limitations of the study are raised and adequately discussed.
Findings (i.e., associations between the explored diseases) may help to advance
understanding and clinical management in the field.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:The relationship between irritable bowel syndrome, functional dyspepsia,
chronic fatigue and overactive bladder syndrome: A controlled study 6 years after
acute gastrointestinal infection.
Version:1Date:18 March 2015
Reviewer: Francesco Luzza
Reviewer's report:
In this study authors reported an higher prevalence of overactive bladder
syndrome (OBS) in a cohort of 724 individuals with laboratory confirmed
giardiasis six years earlier compared with 847 controls matched by gender and
sex (18.7% vs 13.6%). However, this association disappeared when other
comorbid disorders, such as irritable bowel syndrome (IBS), chronic fatigue
syndrome (CFS), and functional dyspepsia (FD), were controlled for. Indeed, the
prevalence of OAB among individuals with no comorbid IBS, CFS, and FD was
quite similar in Giardia exposed and controls (12.4% vs 10.9%). Nevertheless,
the proportion of OAB in the Giardia cohort that could have been prevented had
not individuals been exposed to Giardia was considerably lower than that for any
of the other functional disorders (27.5% vs 70.3, 64%, and 68.6% in IBS, CFS,
and FD, respectively). Authors also found that CFS and sporadic, but not
post-infectious, IBS were associated with increased risk of OAB.
The study is well written, methods are appropriate, and data well presented and
discussed. The limitations of the study are raised and adequately discussed.
Findings (i.e., associations between the explored diseases) may help to advance
understanding and clinical management in the field.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:The relationship between irritable bowel syndrome, functional dyspepsia,
chronic fatigue and overactive bladder syndrome: A controlled study 6 years after
acute gastrointestinal infection.
Version:1Date:18 March 2015
Reviewer: Francesco Luzza
Reviewer's report:
In this study authors reported an higher prevalence of overactive bladder
syndrome (OBS) in a cohort of 724 individuals with laboratory confirmed
giardiasis six years earlier compared with 847 controls matched by gender and
sex (18.7% vs 13.6%). However, this association disappeared when other
comorbid disorders, such as irritable bowel syndrome (IBS), chronic fatigue
syndrome (CFS), and functional dyspepsia (FD), were controlled for. Indeed, the
prevalence of OAB among individuals with no comorbid IBS, CFS, and FD was
quite similar in Giardia exposed and controls (12.4% vs 10.9%). Nevertheless,
the proportion of OAB in the Giardia cohort that could have been prevented had
not individuals been exposed to Giardia was considerably lower than that for any
of the other functional disorders (27.5% vs 70.3, 64%, and 68.6% in IBS, CFS,
and FD, respectively). Authors also found that CFS and sporadic, but not
post-infectious, IBS were associated with increased risk of OAB.
The study is well written, methods are appropriate, and data well presented and
discussed. The limitations of the study are raised and adequately discussed.
Findings (i.e., associations between the explored diseases) may help to advance
understanding and clinical management in the field.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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