Title: RARB associated with MSI, affects progression and prognosis of gastric cancer
Version: 1 Date: 25 Nov 2023
Reviewer's report:
This article solely focuses on the association of the RARB gene with MSI (microsatellite
instability) gastric cancer at the level of tissue and cellular expression. It indicates a positive
correlation between RARB and mismatch repair proteins, with RARB being underexpressed
in MSI gastric cancers. The study suggests that low expression of RARB appears to promote
cancer progression and leads to poor prognosis, as reduced RARB expression accelerates the
proliferation, invasion, and migration of cancer cells. However, the article does not delve into
the specific mechanisms linking RARB to MSI gastric cancer, nor does it address the regulatory
mechanisms of MSI-related target genes. The depth of research is relatively shallow, and the
writing quality of the authors is subpar. For these reasons, it is recommended not to accept this
article for publication.
Title: RARB associated with MSI, affects progression and prognosis of gastric cancer
Version: 1 Date: 25 Nov 2023
Reviewer's report:
This article solely focuses on the association of the RARB gene with MSI (microsatellite
instability) gastric cancer at the level of tissue and cellular expression. It indicates a positive
correlation between RARB and mismatch repair proteins, with RARB being underexpressed
in MSI gastric cancers. The study suggests that low expression of RARB appears to promote
cancer progression and leads to poor prognosis, as reduced RARB expression accelerates the
proliferation, invasion, and migration of cancer cells. However, the article does not delve into
the specific mechanisms linking RARB to MSI gastric cancer, nor does it address the regulatory
mechanisms of MSI-related target genes. The depth of research is relatively shallow, and the
writing quality of the authors is subpar. For these reasons, it is recommended not to accept this
article for publication.
Please review this paper.
user
Title: RARB associated with MSI, affects progression and prognosis of gastric cancer
Version: 1 Date: 25 Nov 2023
Reviewer's report:
This article solely focuses on the association of the RARB gene with MSI (microsatellite
instability) gastric cancer at the level of tissue and cellular expression. It indicates a positive
correlation between RARB and mismatch repair proteins, with RARB being underexpressed
in MSI gastric cancers. The study suggests that low expression of RARB appears to promote
cancer progression and leads to poor prognosis, as reduced RARB expression accelerates the
proliferation, invasion, and migration of cancer cells. However, the article does not delve into
the specific mechanisms linking RARB to MSI gastric cancer, nor does it address the regulatory
mechanisms of MSI-related target genes. The depth of research is relatively shallow, and the
writing quality of the authors is subpar. For these reasons, it is recommended not to accept this
article for publication.
assistant