Title: Latent profiles of fatigue in inflammatory bowel disease
Version: 1 Date: 13 Feb 2024
Reviewer:  Akshay Kulkarni
Reviewer's report:
1. Congratulations to the authors, for being the first group to review a very pertinent conundrum
in IBD practice. Fatigue is indeed an under-diagnosed & under-evaluated clinical problem in
these populations.
2. I would like to know why a majority of patients in your study have Crohn’s disease. In most of
the national registries, ulcerative colitis is more common. Is there an evidence from population
prevalence studies that Australia has more Crohn’s than Ulcerative colitis?
3. Was there any correction placed before estimating the prevalence of fatigue in steroid users,
given that fatigue is a known adverse effect of steroids? Otherwise, fatigue in steroid users may
simply get correlated with IBD activity. Kindly oblige & provide a clarification.
4. Were the profiles correlated with nutritional deficiencies such as anemia and Vitamin D
deficiency? What was the correlation?
Title: Latent profiles of fatigue in inflammatory bowel disease
Version: 1 Date: 13 Feb 2024
Reviewer:  Akshay Kulkarni
Reviewer's report:
1. Congratulations to the authors, for being the first group to review a very pertinent conundrum
in IBD practice. Fatigue is indeed an under-diagnosed & under-evaluated clinical problem in
these populations.
2. I would like to know why a majority of patients in your study have Crohn’s disease. In most of
the national registries, ulcerative colitis is more common. Is there an evidence from population
prevalence studies that Australia has more Crohn’s than Ulcerative colitis?
3. Was there any correction placed before estimating the prevalence of fatigue in steroid users,
given that fatigue is a known adverse effect of steroids? Otherwise, fatigue in steroid users may
simply get correlated with IBD activity. Kindly oblige & provide a clarification.
4. Were the profiles correlated with nutritional deficiencies such as anemia and Vitamin D
deficiency? What was the correlation?
Please review this paper.
user
Title: Latent profiles of fatigue in inflammatory bowel disease
Version: 1 Date: 13 Feb 2024
Reviewer:  Akshay Kulkarni
Reviewer's report:
1. Congratulations to the authors, for being the first group to review a very pertinent conundrum
in IBD practice. Fatigue is indeed an under-diagnosed & under-evaluated clinical problem in
these populations.
2. I would like to know why a majority of patients in your study have Crohn’s disease. In most of
the national registries, ulcerative colitis is more common. Is there an evidence from population
prevalence studies that Australia has more Crohn’s than Ulcerative colitis?
3. Was there any correction placed before estimating the prevalence of fatigue in steroid users,
given that fatigue is a known adverse effect of steroids? Otherwise, fatigue in steroid users may
simply get correlated with IBD activity. Kindly oblige & provide a clarification.
4. Were the profiles correlated with nutritional deficiencies such as anemia and Vitamin D
deficiency? What was the correlation?
assistant