Reviewer's report
Title:Screening for adrenal suppression in children with inflammatory bowel
disease discontinuing glucocorticoid therapy
Version:1Date:4 March 2014
Reviewer: Corinne Gower-Rousseau
Reviewer's report:
Dear authors
I reviewed the paper entitled "Screening for adrenal suppression in children with
IBD discontinuing glucorticoid therapy" submitted by SIdoroff et al for publication
in BMC Gastroenterology.
This is an interesting rétrospective study performed through a referral pediatric
center on an important subject.
I have some minor comments.
1. In the abstract introduction the authors must "estimate" in their referral
population (non representative of general population) the frequency of adrenal
insuffisiency and not the prevalence.
2. In the method section does the médian age concern median age at diagnosis
or at the study performed?
3. In the results part, 20% of children have a morning cortisol below the reference
and 10% of children have an undetectable range of morning cortisol. Are these
10% included into the first 20%? The authors must explain.
4. In the Introduction section regarding the worldwide increase of the incidence in
children, the authors could refer the paper published by Chouraki et al in
Alimentary Pharmacol and Therap in 2011 founding a double incidence of CD in
children and adolescents in a French population-based study from 1988 to 2007.
5. Regarding the results of glucocorticoid dependency the authors must refer to
the paper published by Vernier-Massouille in Gastroenterology in 2008.
6. Could the authors give more details on the IBD diagnosis criteria used in this
study?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
Reviewer's report
Title:Screening for adrenal suppression in children with inflammatory bowel
disease discontinuing glucocorticoid therapy
Version:1Date:4 March 2014
Reviewer: Corinne Gower-Rousseau
Reviewer's report:
Dear authors
I reviewed the paper entitled "Screening for adrenal suppression in children with
IBD discontinuing glucorticoid therapy" submitted by SIdoroff et al for publication
in BMC Gastroenterology.
This is an interesting rétrospective study performed through a referral pediatric
center on an important subject.
I have some minor comments.
1. In the abstract introduction the authors must "estimate" in their referral
population (non representative of general population) the frequency of adrenal
insuffisiency and not the prevalence.
2. In the method section does the médian age concern median age at diagnosis
or at the study performed?
3. In the results part, 20% of children have a morning cortisol below the reference
and 10% of children have an undetectable range of morning cortisol. Are these
10% included into the first 20%? The authors must explain.
4. In the Introduction section regarding the worldwide increase of the incidence in
children, the authors could refer the paper published by Chouraki et al in
Alimentary Pharmacol and Therap in 2011 founding a double incidence of CD in
children and adolescents in a French population-based study from 1988 to 2007.
5. Regarding the results of glucocorticoid dependency the authors must refer to
the paper published by Vernier-Massouille in Gastroenterology in 2008.
6. Could the authors give more details on the IBD diagnosis criteria used in this
study?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
Please review this paper.
user
Reviewer's report
Title:Screening for adrenal suppression in children with inflammatory bowel
disease discontinuing glucocorticoid therapy
Version:1Date:4 March 2014
Reviewer: Corinne Gower-Rousseau
Reviewer's report:
Dear authors
I reviewed the paper entitled "Screening for adrenal suppression in children with
IBD discontinuing glucorticoid therapy" submitted by SIdoroff et al for publication
in BMC Gastroenterology.
This is an interesting rétrospective study performed through a referral pediatric
center on an important subject.
I have some minor comments.
1. In the abstract introduction the authors must "estimate" in their referral
population (non representative of general population) the frequency of adrenal
insuffisiency and not the prevalence.
2. In the method section does the médian age concern median age at diagnosis
or at the study performed?
3. In the results part, 20% of children have a morning cortisol below the reference
and 10% of children have an undetectable range of morning cortisol. Are these
10% included into the first 20%? The authors must explain.
4. In the Introduction section regarding the worldwide increase of the incidence in
children, the authors could refer the paper published by Chouraki et al in
Alimentary Pharmacol and Therap in 2011 founding a double incidence of CD in
children and adolescents in a French population-based study from 1988 to 2007.
5. Regarding the results of glucocorticoid dependency the authors must refer to
the paper published by Vernier-Massouille in Gastroenterology in 2008.
6. Could the authors give more details on the IBD diagnosis criteria used in this
study?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
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