Title: Omeprazole taken once every other day can effectively prevent aspirin-induced
gastrointestinal mucosal damage in rats
Version: 3 Date: 19 Feb 2024
Reviewer:  Mohamed Hashim
Reviewer's report:
This study addresses an important issue in clinical practice.
Some points need to be addressed
Small sample size.
(In addition, in clinical work, patients with aspirin-related peptic ulcers took the standard dose
of omeprazole every other day, and ulcer healing was checked by gastroscopy after 2 months).
No of patients was 2 from which you can not get a conclusion.
Here the aim is different as the authors used PPI for treatment rather than prevention.
The study needs to be applied in human being in order to verify results.
The type of PPI used not to be addressed, whether it affects the results. This should be
emphasized in the discussion.
Title: Omeprazole taken once every other day can effectively prevent aspirin-induced
gastrointestinal mucosal damage in rats
Version: 3 Date: 19 Feb 2024
Reviewer:  Mohamed Hashim
Reviewer's report:
This study addresses an important issue in clinical practice.
Some points need to be addressed
Small sample size.
(In addition, in clinical work, patients with aspirin-related peptic ulcers took the standard dose
of omeprazole every other day, and ulcer healing was checked by gastroscopy after 2 months).
No of patients was 2 from which you can not get a conclusion.
Here the aim is different as the authors used PPI for treatment rather than prevention.
The study needs to be applied in human being in order to verify results.
The type of PPI used not to be addressed, whether it affects the results. This should be
emphasized in the discussion.
Please review this paper.
user
Title: Omeprazole taken once every other day can effectively prevent aspirin-induced
gastrointestinal mucosal damage in rats
Version: 3 Date: 19 Feb 2024
Reviewer:  Mohamed Hashim
Reviewer's report:
This study addresses an important issue in clinical practice.
Some points need to be addressed
Small sample size.
(In addition, in clinical work, patients with aspirin-related peptic ulcers took the standard dose
of omeprazole every other day, and ulcer healing was checked by gastroscopy after 2 months).
No of patients was 2 from which you can not get a conclusion.
Here the aim is different as the authors used PPI for treatment rather than prevention.
The study needs to be applied in human being in order to verify results.
The type of PPI used not to be addressed, whether it affects the results. This should be
emphasized in the discussion.
assistant