Title: Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA
clearance in chronic hepatitis b patients
Version: 2 Date: 03 Nov 2024
Reviewer's report:
Dear sir,
thank you to select  me to review an article "The curative impact of reduced glutathione on
chronic hepatitis B sufferers and liver function and fibrosis" written by Wei and Zhao. The
authors compared reduced glutathione and entecavir in chronic hepatitis B patients after surgery.
Design of the study is not correctly chosen, because HBV patients need to be treated by
nucleot(s)ide analogues.  Patients treated with reduced glutathione (which isn´t antiviral drug
for HBV infection) didn´t receive antiviral treatment. Design of the study is not described in
detail (type of surgery etc..).  Although liver decompensation was an exclusion criterion in this
study, mean bilirubin level in both arms was about 60 µmol /L.  Reduced glutathione had worse
effect on HBV DNA  loss compared to entecavir.
My final decision is rejection.
Title: Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA
clearance in chronic hepatitis b patients
Version: 2 Date: 03 Nov 2024
Reviewer's report:
Dear sir,
thank you to select  me to review an article "The curative impact of reduced glutathione on
chronic hepatitis B sufferers and liver function and fibrosis" written by Wei and Zhao. The
authors compared reduced glutathione and entecavir in chronic hepatitis B patients after surgery.
Design of the study is not correctly chosen, because HBV patients need to be treated by
nucleot(s)ide analogues.  Patients treated with reduced glutathione (which isn´t antiviral drug
for HBV infection) didn´t receive antiviral treatment. Design of the study is not described in
detail (type of surgery etc..).  Although liver decompensation was an exclusion criterion in this
study, mean bilirubin level in both arms was about 60 µmol /L.  Reduced glutathione had worse
effect on HBV DNA  loss compared to entecavir.
My final decision is rejection.
Please review this paper.
user
Title: Therapeutic effects of reduced glutathione on liver function, fibrosis, and HBV DNA
clearance in chronic hepatitis b patients
Version: 2 Date: 03 Nov 2024
Reviewer's report:
Dear sir,
thank you to select  me to review an article "The curative impact of reduced glutathione on
chronic hepatitis B sufferers and liver function and fibrosis" written by Wei and Zhao. The
authors compared reduced glutathione and entecavir in chronic hepatitis B patients after surgery.
Design of the study is not correctly chosen, because HBV patients need to be treated by
nucleot(s)ide analogues.  Patients treated with reduced glutathione (which isn´t antiviral drug
for HBV infection) didn´t receive antiviral treatment. Design of the study is not described in
detail (type of surgery etc..).  Although liver decompensation was an exclusion criterion in this
study, mean bilirubin level in both arms was about 60 µmol /L.  Reduced glutathione had worse
effect on HBV DNA  loss compared to entecavir.
My final decision is rejection.
assistant