Title: methylated Septin9 has moderate diagnostic value in colorectal cancer detection in
Chinese population: a multicenter study
Version: 1 Date: 06 Apr 2022
Reviewer's report:
Lu and colleagues have evaluated the diagnostic potential of methylated SEPT9 in colorectal
cancer and compared to that of FIT and other tests. As authors mentioned diagnostic potential
of mSEPT9 has been evaluated previously in multiple studies. However, a direct comparison
between mSEPT9 to FIT and other CRC tests in the matching cohort provides meaningful data.
Authors should provide additional data on the comparison between mSEPT9 and FIT.
A title that reflects the outcome of the study may be more meaningful to reader than the current
generic title. While mSEPT9 may not have outperformed FIT for CRC diagnosis, it is an
important data and worth reflecting in your title.
Can you provide additional diagnostic values for different cancer stages for mSEPT9 and FIT
and compare their efficacy? For example, looking at their efficacy for stages 1-2 and 3-4 and
evaluate which assay performs better.
What was the statistical test used to compare AUCs of mSEPT9 and FIT? Method does not seem
to be included in the methodology. Please add the comparison method in the methods section.
Title: methylated Septin9 has moderate diagnostic value in colorectal cancer detection in
Chinese population: a multicenter study
Version: 1 Date: 06 Apr 2022
Reviewer's report:
Lu and colleagues have evaluated the diagnostic potential of methylated SEPT9 in colorectal
cancer and compared to that of FIT and other tests. As authors mentioned diagnostic potential
of mSEPT9 has been evaluated previously in multiple studies. However, a direct comparison
between mSEPT9 to FIT and other CRC tests in the matching cohort provides meaningful data.
Authors should provide additional data on the comparison between mSEPT9 and FIT.
A title that reflects the outcome of the study may be more meaningful to reader than the current
generic title. While mSEPT9 may not have outperformed FIT for CRC diagnosis, it is an
important data and worth reflecting in your title.
Can you provide additional diagnostic values for different cancer stages for mSEPT9 and FIT
and compare their efficacy? For example, looking at their efficacy for stages 1-2 and 3-4 and
evaluate which assay performs better.
What was the statistical test used to compare AUCs of mSEPT9 and FIT? Method does not seem
to be included in the methodology. Please add the comparison method in the methods section.
Please review this paper.
user
Title: methylated Septin9 has moderate diagnostic value in colorectal cancer detection in
Chinese population: a multicenter study
Version: 1 Date: 06 Apr 2022
Reviewer's report:
Lu and colleagues have evaluated the diagnostic potential of methylated SEPT9 in colorectal
cancer and compared to that of FIT and other tests. As authors mentioned diagnostic potential
of mSEPT9 has been evaluated previously in multiple studies. However, a direct comparison
between mSEPT9 to FIT and other CRC tests in the matching cohort provides meaningful data.
Authors should provide additional data on the comparison between mSEPT9 and FIT.
A title that reflects the outcome of the study may be more meaningful to reader than the current
generic title. While mSEPT9 may not have outperformed FIT for CRC diagnosis, it is an
important data and worth reflecting in your title.
Can you provide additional diagnostic values for different cancer stages for mSEPT9 and FIT
and compare their efficacy? For example, looking at their efficacy for stages 1-2 and 3-4 and
evaluate which assay performs better.
What was the statistical test used to compare AUCs of mSEPT9 and FIT? Method does not seem
to be included in the methodology. Please add the comparison method in the methods section.
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