Title: Influencing factors and predictive model of postoperative infection in patients with
primary hepatic carcinoma
Version: 2 Date: 30 Dec 2022
Reviewer's report:
Dear Editor,
Thank you so much for inviting me to revise this manuscript.
In the study entitled "Influencing factors and predictive model of postoperative infection in
patients with primary hepatic carcinoma" Ma et al showed a nomogram prediction model of
postoperative infection. We think this is a piece worth publishing, even if there are a few flaws.
Below a detailed list of my concerns.
1. The manuscript is quite well written and organized. Typing and grammatical errors should be
carefully checked throughout the manuscript.
2. The authors should provide information on their general policy for PHC management. For
instance, do they follow the BCLC algorithm? How these patients were selected for surgery? At
the same time, this part of the content should be reflected in the inclusion or exclusion criteria.
3. Instruction: " Postoperative infection was the most common type of postoperative infection,
with an incidence of 9.0% of patients, followed by surgical site infection " The expression of
this part is wrong.
4. Instruction: " In this study, we performed univariate and multifactorial cox regression analysis
on clinical information and indicators of hepatectomy patients to find the risk factors of
postoperative infection " However, Cox regression did not used in this article.
5. Materials and methods: " Guidelines for the Diagnosis and Treatment of Hepatocellular
Carcinoma (2019 Edition) " The latest edition should be 2022.
6. In the Logistic multivariate regression analysis, AFP (OR = 1.000). However, It should not
be used for modeling when a variable’s OR value equal to 1.
7. In the Table 2, what is the meaning of intercept?  If it is redundant, delete it
8. "In addition, effective intraoperative blood transfusion has a preventive effect in avoiding
postoperative infections. " It doesn't fit our perception and clinical practice
9. Discussion: "Surgical resection is the main form of treatment" This sentence makes me
confused.
10. Discussion: "intraoperative blood loss is usually accompanied by perioperative blood
transfusion, which also increases susceptibility to postoperative infection." This seems to be
inconsistent with the results of the authors' multivariate analysis.
11. Some abbreviations should be written in full for the first time. Such as: HBV DNA, ROC
curve, et al.
12.  It should have a detailed discussion why the Perioperative blood Transfusion is a protective
factor.
13. Figure legends should be precisely explained, just only the name of the Table is probably
not enough.
14. Surgical procedure should be described (e.g., Endoscopic surgery or laparotomy).
15. The list of reference should be checked carefully.
Title: Influencing factors and predictive model of postoperative infection in patients with
primary hepatic carcinoma
Version: 2 Date: 30 Dec 2022
Reviewer's report:
Dear Editor,
Thank you so much for inviting me to revise this manuscript.
In the study entitled "Influencing factors and predictive model of postoperative infection in
patients with primary hepatic carcinoma" Ma et al showed a nomogram prediction model of
postoperative infection. We think this is a piece worth publishing, even if there are a few flaws.
Below a detailed list of my concerns.
1. The manuscript is quite well written and organized. Typing and grammatical errors should be
carefully checked throughout the manuscript.
2. The authors should provide information on their general policy for PHC management. For
instance, do they follow the BCLC algorithm? How these patients were selected for surgery? At
the same time, this part of the content should be reflected in the inclusion or exclusion criteria.
3. Instruction: " Postoperative infection was the most common type of postoperative infection,
with an incidence of 9.0% of patients, followed by surgical site infection " The expression of
this part is wrong.
4. Instruction: " In this study, we performed univariate and multifactorial cox regression analysis
on clinical information and indicators of hepatectomy patients to find the risk factors of
postoperative infection " However, Cox regression did not used in this article.
5. Materials and methods: " Guidelines for the Diagnosis and Treatment of Hepatocellular
Carcinoma (2019 Edition) " The latest edition should be 2022.
6. In the Logistic multivariate regression analysis, AFP (OR = 1.000). However, It should not
be used for modeling when a variable’s OR value equal to 1.
7. In the Table 2, what is the meaning of intercept?  If it is redundant, delete it
8. "In addition, effective intraoperative blood transfusion has a preventive effect in avoiding
postoperative infections. " It doesn't fit our perception and clinical practice
9. Discussion: "Surgical resection is the main form of treatment" This sentence makes me
confused.
10. Discussion: "intraoperative blood loss is usually accompanied by perioperative blood
transfusion, which also increases susceptibility to postoperative infection." This seems to be
inconsistent with the results of the authors' multivariate analysis.
11. Some abbreviations should be written in full for the first time. Such as: HBV DNA, ROC
curve, et al.
12.  It should have a detailed discussion why the Perioperative blood Transfusion is a protective
factor.
13. Figure legends should be precisely explained, just only the name of the Table is probably
not enough.
14. Surgical procedure should be described (e.g., Endoscopic surgery or laparotomy).
15. The list of reference should be checked carefully.
Please review this paper.
user
Title: Influencing factors and predictive model of postoperative infection in patients with
primary hepatic carcinoma
Version: 2 Date: 30 Dec 2022
Reviewer's report:
Dear Editor,
Thank you so much for inviting me to revise this manuscript.
In the study entitled "Influencing factors and predictive model of postoperative infection in
patients with primary hepatic carcinoma" Ma et al showed a nomogram prediction model of
postoperative infection. We think this is a piece worth publishing, even if there are a few flaws.
Below a detailed list of my concerns.
1. The manuscript is quite well written and organized. Typing and grammatical errors should be
carefully checked throughout the manuscript.
2. The authors should provide information on their general policy for PHC management. For
instance, do they follow the BCLC algorithm? How these patients were selected for surgery? At
the same time, this part of the content should be reflected in the inclusion or exclusion criteria.
3. Instruction: " Postoperative infection was the most common type of postoperative infection,
with an incidence of 9.0% of patients, followed by surgical site infection " The expression of
this part is wrong.
4. Instruction: " In this study, we performed univariate and multifactorial cox regression analysis
on clinical information and indicators of hepatectomy patients to find the risk factors of
postoperative infection " However, Cox regression did not used in this article.
5. Materials and methods: " Guidelines for the Diagnosis and Treatment of Hepatocellular
Carcinoma (2019 Edition) " The latest edition should be 2022.
6. In the Logistic multivariate regression analysis, AFP (OR = 1.000). However, It should not
be used for modeling when a variable’s OR value equal to 1.
7. In the Table 2, what is the meaning of intercept?  If it is redundant, delete it
8. "In addition, effective intraoperative blood transfusion has a preventive effect in avoiding
postoperative infections. " It doesn't fit our perception and clinical practice
9. Discussion: "Surgical resection is the main form of treatment" This sentence makes me
confused.
10. Discussion: "intraoperative blood loss is usually accompanied by perioperative blood
transfusion, which also increases susceptibility to postoperative infection." This seems to be
inconsistent with the results of the authors' multivariate analysis.
11. Some abbreviations should be written in full for the first time. Such as: HBV DNA, ROC
curve, et al.
12.  It should have a detailed discussion why the Perioperative blood Transfusion is a protective
factor.
13. Figure legends should be precisely explained, just only the name of the Table is probably
not enough.
14. Surgical procedure should be described (e.g., Endoscopic surgery or laparotomy).
15. The list of reference should be checked carefully.
assistant