Title: Risk factors for metachronous colorectal cancer and advanced neoplasia following
primary colorectal cancer: A systematic review and meta-analysis
Version: 0 Date: 09 Jul 2023
Reviewer's report:
This is a comprehensive, yet difficult study design since few publications in the literature include
all the parameters that the authors want to include in their study. Consequently, as the authors
acknowledged, the study is mostly inconclusive.
For pathologic review, I assume the study only included cases without any follow-up/additional
treatment after the curative surgical procedure.  Please specify if that is the case.  I also don't
quite understand the difference between TNM staging versus T staging in the report, the data
there appear to be conflicted.
I think it would be beneficial for the journal to invite a biostatistician to review this study and
I defer the comments on the statistical data to a statistician.
Title: Risk factors for metachronous colorectal cancer and advanced neoplasia following
primary colorectal cancer: A systematic review and meta-analysis
Version: 0 Date: 09 Jul 2023
Reviewer's report:
This is a comprehensive, yet difficult study design since few publications in the literature include
all the parameters that the authors want to include in their study. Consequently, as the authors
acknowledged, the study is mostly inconclusive.
For pathologic review, I assume the study only included cases without any follow-up/additional
treatment after the curative surgical procedure.  Please specify if that is the case.  I also don't
quite understand the difference between TNM staging versus T staging in the report, the data
there appear to be conflicted.
I think it would be beneficial for the journal to invite a biostatistician to review this study and
I defer the comments on the statistical data to a statistician.
Please review this paper.
user
Title: Risk factors for metachronous colorectal cancer and advanced neoplasia following
primary colorectal cancer: A systematic review and meta-analysis
Version: 0 Date: 09 Jul 2023
Reviewer's report:
This is a comprehensive, yet difficult study design since few publications in the literature include
all the parameters that the authors want to include in their study. Consequently, as the authors
acknowledged, the study is mostly inconclusive.
For pathologic review, I assume the study only included cases without any follow-up/additional
treatment after the curative surgical procedure.  Please specify if that is the case.  I also don't
quite understand the difference between TNM staging versus T staging in the report, the data
there appear to be conflicted.
I think it would be beneficial for the journal to invite a biostatistician to review this study and
I defer the comments on the statistical data to a statistician.
assistant