Title: The relationships between depression, inflammation and self-reported disease activity in
IBD and their impact on healthcare usage.
Version: 2 Date: 01 Dec 2024
Reviewer:  Yüksel Do#an
Reviewer's report:
What is the article about, what is new?
This article examines the association between depression, self-reported disease activity (SRDA)
and objective measures of inflammation (faecal calprotectin) in people with IBD. It assesses
whether these factors predict healthcare utilisation and economic indicators. The study
highlights the interaction between psychological factors and IBD management using data from
a randomised controlled trial.
As SRDA emerged as a stronger predictor of depression and functional outcomes than FCP, it
suggests that addressing patients' perceptions of disease control may be critical.
Being unemployed appears to play an important role in predicting increased depression. Specific
interventions to support work engagement or vocational rehabilitation may reduce this burden.
Collaborative care models, particularly for younger people and those with high SRDA scores,
combining psychological and medical management may improve outcomes.
1. Missing parts of the article
The introduction could further describe the implications of the gut-brain axis for therapeutic
strategies.
Mechanisms behind the lack of correlation between faecal calprotectin (FCP) and depression
are poorly discussed.
2.. Gaps in grammar
Inconsistent use of tenses (e.g. 'is' and 'was').
Strange phrasing in some sentences such as "Depression and inflammation may be causally
linked in IBD through the gut-brain axis..." could be made more precise.
Minor grammatical errors such as using unnecessary commas and misusing articles (e.g.
"Depression was also associated with..." instead of "Depression was also associated with...").
The data show complex associations between depression, disease activity and inflammation in
IBD. Highlights include the associations between depression and socio-demographic variables
and the predictors of disease activity and inflammation.
Title: The relationships between depression, inflammation and self-reported disease activity in
IBD and their impact on healthcare usage.
Version: 2 Date: 01 Dec 2024
Reviewer:  Yüksel Do#an
Reviewer's report:
What is the article about, what is new?
This article examines the association between depression, self-reported disease activity (SRDA)
and objective measures of inflammation (faecal calprotectin) in people with IBD. It assesses
whether these factors predict healthcare utilisation and economic indicators. The study
highlights the interaction between psychological factors and IBD management using data from
a randomised controlled trial.
As SRDA emerged as a stronger predictor of depression and functional outcomes than FCP, it
suggests that addressing patients' perceptions of disease control may be critical.
Being unemployed appears to play an important role in predicting increased depression. Specific
interventions to support work engagement or vocational rehabilitation may reduce this burden.
Collaborative care models, particularly for younger people and those with high SRDA scores,
combining psychological and medical management may improve outcomes.
1. Missing parts of the article
The introduction could further describe the implications of the gut-brain axis for therapeutic
strategies.
Mechanisms behind the lack of correlation between faecal calprotectin (FCP) and depression
are poorly discussed.
2.. Gaps in grammar
Inconsistent use of tenses (e.g. 'is' and 'was').
Strange phrasing in some sentences such as "Depression and inflammation may be causally
linked in IBD through the gut-brain axis..." could be made more precise.
Minor grammatical errors such as using unnecessary commas and misusing articles (e.g.
"Depression was also associated with..." instead of "Depression was also associated with...").
The data show complex associations between depression, disease activity and inflammation in
IBD. Highlights include the associations between depression and socio-demographic variables
and the predictors of disease activity and inflammation.
Please review this paper.
user
Title: The relationships between depression, inflammation and self-reported disease activity in
IBD and their impact on healthcare usage.
Version: 2 Date: 01 Dec 2024
Reviewer:  Yüksel Do#an
Reviewer's report:
What is the article about, what is new?
This article examines the association between depression, self-reported disease activity (SRDA)
and objective measures of inflammation (faecal calprotectin) in people with IBD. It assesses
whether these factors predict healthcare utilisation and economic indicators. The study
highlights the interaction between psychological factors and IBD management using data from
a randomised controlled trial.
As SRDA emerged as a stronger predictor of depression and functional outcomes than FCP, it
suggests that addressing patients' perceptions of disease control may be critical.
Being unemployed appears to play an important role in predicting increased depression. Specific
interventions to support work engagement or vocational rehabilitation may reduce this burden.
Collaborative care models, particularly for younger people and those with high SRDA scores,
combining psychological and medical management may improve outcomes.
1. Missing parts of the article
The introduction could further describe the implications of the gut-brain axis for therapeutic
strategies.
Mechanisms behind the lack of correlation between faecal calprotectin (FCP) and depression
are poorly discussed.
2.. Gaps in grammar
Inconsistent use of tenses (e.g. 'is' and 'was').
Strange phrasing in some sentences such as "Depression and inflammation may be causally
linked in IBD through the gut-brain axis..." could be made more precise.
Minor grammatical errors such as using unnecessary commas and misusing articles (e.g.
"Depression was also associated with..." instead of "Depression was also associated with...").
The data show complex associations between depression, disease activity and inflammation in
IBD. Highlights include the associations between depression and socio-demographic variables
and the predictors of disease activity and inflammation.
assistant