Title: Additive effect of evaluating microsurface and microvascular patterns using magnifying
endoscopy with narrow-band imaging in gastric cancer: a post hoc analysis of a single- center
observational study
Version: 1 Date: 05 Jan 2022
Reviewer's report:
There are many reports on the diagnostic performance of MS and MV in the diagnosis of gastric
cancer using ME-NBI. In order to increase the scientific strength of this paper, the following
modifications should be made.
Comment 1: The non-cancerous image used in this study appears to be the gastric mucosa
around the lesion obtained prior to ESD. It is necessary to describe whether the non-cancerous
image is erosion due to inflammation, the surrounding intestinal metaplasia mucosa, or the
mucosa without atrophy. The characteristics of the histopathology of the non-cancerous image
are important information and should be additionally described.
Comment 2: Please clearly describe in each MS and MV what findings are observed in this
analysis to diagnose cancer.
Comment 3: Table 3 is confusing and should be changed to something that is easier for the
reader to understand.
Comment 4: Table 5 seems to show the characteristics of lesions that are difficult to diagnose
by MV. Since the notation of the table is complicated, it should be revised to a table that is easy
for the reader to understand.
Title: Additive effect of evaluating microsurface and microvascular patterns using magnifying
endoscopy with narrow-band imaging in gastric cancer: a post hoc analysis of a single- center
observational study
Version: 1 Date: 05 Jan 2022
Reviewer's report:
There are many reports on the diagnostic performance of MS and MV in the diagnosis of gastric
cancer using ME-NBI. In order to increase the scientific strength of this paper, the following
modifications should be made.
Comment 1: The non-cancerous image used in this study appears to be the gastric mucosa
around the lesion obtained prior to ESD. It is necessary to describe whether the non-cancerous
image is erosion due to inflammation, the surrounding intestinal metaplasia mucosa, or the
mucosa without atrophy. The characteristics of the histopathology of the non-cancerous image
are important information and should be additionally described.
Comment 2: Please clearly describe in each MS and MV what findings are observed in this
analysis to diagnose cancer.
Comment 3: Table 3 is confusing and should be changed to something that is easier for the
reader to understand.
Comment 4: Table 5 seems to show the characteristics of lesions that are difficult to diagnose
by MV. Since the notation of the table is complicated, it should be revised to a table that is easy
for the reader to understand.
Please review this paper.
user
Title: Additive effect of evaluating microsurface and microvascular patterns using magnifying
endoscopy with narrow-band imaging in gastric cancer: a post hoc analysis of a single- center
observational study
Version: 1 Date: 05 Jan 2022
Reviewer's report:
There are many reports on the diagnostic performance of MS and MV in the diagnosis of gastric
cancer using ME-NBI. In order to increase the scientific strength of this paper, the following
modifications should be made.
Comment 1: The non-cancerous image used in this study appears to be the gastric mucosa
around the lesion obtained prior to ESD. It is necessary to describe whether the non-cancerous
image is erosion due to inflammation, the surrounding intestinal metaplasia mucosa, or the
mucosa without atrophy. The characteristics of the histopathology of the non-cancerous image
are important information and should be additionally described.
Comment 2: Please clearly describe in each MS and MV what findings are observed in this
analysis to diagnose cancer.
Comment 3: Table 3 is confusing and should be changed to something that is easier for the
reader to understand.
Comment 4: Table 5 seems to show the characteristics of lesions that are difficult to diagnose
by MV. Since the notation of the table is complicated, it should be revised to a table that is easy
for the reader to understand.
assistant