Title: Abnormal Platelet Parameters in Inflammatory Bowel Disease: A Systematic Review and
Meta-Analysis
Version: 1 Date: 05 Apr 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are major issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: - The topic is interesting, mainly if possible clinical applications for
patients' monitoring are taken into account
- The authors have done an extensive search in the literature, associated with a deep statistical
analysis
- However I have a few concerns about methodology: - they included papers published from
1975! In those years diagnosis and knowledge of IBD were completely different from recent
years, and this could potentially have an impact on PLT analyses. Maybe it could be interesting
to divide and analyze two groups of patients based on the date of publications.
- the authors excluded from the analysis patients who had taken immunosuppressants; but
nowadays a great number of IBD subjects undergo these treatments. And excluding them "a
priori" could be a major bias for the analysis
REQUESTED REVISIONS:
as suggested above
ADDITIONAL REQUESTS/SUGGESTIONS:
methods as already said
Title: Abnormal Platelet Parameters in Inflammatory Bowel Disease: A Systematic Review and
Meta-Analysis
Version: 1 Date: 05 Apr 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are major issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: - The topic is interesting, mainly if possible clinical applications for
patients' monitoring are taken into account
- The authors have done an extensive search in the literature, associated with a deep statistical
analysis
- However I have a few concerns about methodology: - they included papers published from
1975! In those years diagnosis and knowledge of IBD were completely different from recent
years, and this could potentially have an impact on PLT analyses. Maybe it could be interesting
to divide and analyze two groups of patients based on the date of publications.
- the authors excluded from the analysis patients who had taken immunosuppressants; but
nowadays a great number of IBD subjects undergo these treatments. And excluding them "a
priori" could be a major bias for the analysis
REQUESTED REVISIONS:
as suggested above
ADDITIONAL REQUESTS/SUGGESTIONS:
methods as already said
Please review this paper.
user
Title: Abnormal Platelet Parameters in Inflammatory Bowel Disease: A Systematic Review and
Meta-Analysis
Version: 1 Date: 05 Apr 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are major issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
No - there are major issues
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are major issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: - The topic is interesting, mainly if possible clinical applications for
patients' monitoring are taken into account
- The authors have done an extensive search in the literature, associated with a deep statistical
analysis
- However I have a few concerns about methodology: - they included papers published from
1975! In those years diagnosis and knowledge of IBD were completely different from recent
years, and this could potentially have an impact on PLT analyses. Maybe it could be interesting
to divide and analyze two groups of patients based on the date of publications.
- the authors excluded from the analysis patients who had taken immunosuppressants; but
nowadays a great number of IBD subjects undergo these treatments. And excluding them "a
priori" could be a major bias for the analysis
REQUESTED REVISIONS:
as suggested above
ADDITIONAL REQUESTS/SUGGESTIONS:
methods as already said
assistant