Title: Fatigue in Patients with Inflammatory Bowel Disease - Strongly Influenced by Depression
and not Identifiable through Laboratory Testing: a Cross-Sectional Survey Study
Version: 1 Date: 11 May 2023
Reviewer:  Bhaskar Kante
Reviewer's report:
Dear Author, I want to congratulate on the elegant study on the most under-recognised symptom
i,e fatigue in patients with inflammatory bowel disease. The manuscript was well written,
however, I have a few comments below
Comments :
1. IBD-F is the only scale specific to patients with IBD. Studies have shown that IBD-F correlates
to the MFI and MAF instruments. Why did you choose the FAS scale
2. Can we have data on the extent, location, and behaviour of the disease and any relation with
the presence of fatigue in patients
3. Did you screen for malnutrition in patients as micro and macronutrient deficiencies associated
with fatigue
4.  Studies cited in this paper showed poor sleep increases fatigue in patients of IBD. Any
experience of the effect of sleep on fatigue in your study
5. Using Patient-reported outcomes scores and correlating them with fatigue could give a better
perspective of disease activity's effect on fatigue. Do you have any data on PRO scores
6. Medications play an important role in fatigue scores. Any data on what medications patients
are using during the study
7. Any correlation between employment status on fatigue
8. As mentioned in the discussion section, the effect of age on fatigue in Crohn's disease and
UC depends on the complications, do you have data on behavior and extent of the disease
9. Any effect of surgery on fatigue in the study
10. Discussion needs to be rewritten in a focused way
Title: Fatigue in Patients with Inflammatory Bowel Disease - Strongly Influenced by Depression
and not Identifiable through Laboratory Testing: a Cross-Sectional Survey Study
Version: 1 Date: 11 May 2023
Reviewer:  Bhaskar Kante
Reviewer's report:
Dear Author, I want to congratulate on the elegant study on the most under-recognised symptom
i,e fatigue in patients with inflammatory bowel disease. The manuscript was well written,
however, I have a few comments below
Comments :
1. IBD-F is the only scale specific to patients with IBD. Studies have shown that IBD-F correlates
to the MFI and MAF instruments. Why did you choose the FAS scale
2. Can we have data on the extent, location, and behaviour of the disease and any relation with
the presence of fatigue in patients
3. Did you screen for malnutrition in patients as micro and macronutrient deficiencies associated
with fatigue
4.  Studies cited in this paper showed poor sleep increases fatigue in patients of IBD. Any
experience of the effect of sleep on fatigue in your study
5. Using Patient-reported outcomes scores and correlating them with fatigue could give a better
perspective of disease activity's effect on fatigue. Do you have any data on PRO scores
6. Medications play an important role in fatigue scores. Any data on what medications patients
are using during the study
7. Any correlation between employment status on fatigue
8. As mentioned in the discussion section, the effect of age on fatigue in Crohn's disease and
UC depends on the complications, do you have data on behavior and extent of the disease
9. Any effect of surgery on fatigue in the study
10. Discussion needs to be rewritten in a focused way
Please review this paper.
user
Title: Fatigue in Patients with Inflammatory Bowel Disease - Strongly Influenced by Depression
and not Identifiable through Laboratory Testing: a Cross-Sectional Survey Study
Version: 1 Date: 11 May 2023
Reviewer:  Bhaskar Kante
Reviewer's report:
Dear Author, I want to congratulate on the elegant study on the most under-recognised symptom
i,e fatigue in patients with inflammatory bowel disease. The manuscript was well written,
however, I have a few comments below
Comments :
1. IBD-F is the only scale specific to patients with IBD. Studies have shown that IBD-F correlates
to the MFI and MAF instruments. Why did you choose the FAS scale
2. Can we have data on the extent, location, and behaviour of the disease and any relation with
the presence of fatigue in patients
3. Did you screen for malnutrition in patients as micro and macronutrient deficiencies associated
with fatigue
4.  Studies cited in this paper showed poor sleep increases fatigue in patients of IBD. Any
experience of the effect of sleep on fatigue in your study
5. Using Patient-reported outcomes scores and correlating them with fatigue could give a better
perspective of disease activity's effect on fatigue. Do you have any data on PRO scores
6. Medications play an important role in fatigue scores. Any data on what medications patients
are using during the study
7. Any correlation between employment status on fatigue
8. As mentioned in the discussion section, the effect of age on fatigue in Crohn's disease and
UC depends on the complications, do you have data on behavior and extent of the disease
9. Any effect of surgery on fatigue in the study
10. Discussion needs to be rewritten in a focused way
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