Title: Investigating the Effect of Quadruple Therapy with Saccharomyces Boulardii or
Lactobacillus Reuteri Strain (DSMZ 17648) Supplements on Eradication of Helicobacter Pylori
and Treatments# Adverse effects: A Double-Blind Placebo-Controlled Randomized Clinical
Trial
Version: 2 Date: 13 Nov 2021
Reviewer's report:
The resistance of Helicobacter pylori to antibiotics leads to its eradication rate decreasing year
by year. Combined application of antibiotics can improve the curative effect. The combined use
of antibiotics increased the incidence of adverse reactions. The research on adding probiotics to
Helicobacter pylori eradication treatment is increasing in recent years. The authors investigated
the effect of quadruple treatment with Saccharomyces boulardii or Lactobacillus reuteri on
the eradication of Helicobacter pylori and side effects of the treatment. They found that
the use of probiotic supplements containing S. boulardii or Lactobacillus reuteri improved
the eradication rate of Helicobacter pylori infection, but it was not statistically significant.
S. boulardii supplements could significantly reduce some side effects of Helicobacter pylori
eradication therapy.
There are some problems:
Why all the subjects continued to take proton pump inhibitor (PPI) alone for 14 days after
eradication treatment?
Did all patients complete post-treatment follow-up? No lost patients? Is there any patient who
did not complete the treatment due to adverse reactions?
One limitation of this study is the small sample size.
Title: Investigating the Effect of Quadruple Therapy with Saccharomyces Boulardii or
Lactobacillus Reuteri Strain (DSMZ 17648) Supplements on Eradication of Helicobacter Pylori
and Treatments# Adverse effects: A Double-Blind Placebo-Controlled Randomized Clinical
Trial
Version: 2 Date: 13 Nov 2021
Reviewer's report:
The resistance of Helicobacter pylori to antibiotics leads to its eradication rate decreasing year
by year. Combined application of antibiotics can improve the curative effect. The combined use
of antibiotics increased the incidence of adverse reactions. The research on adding probiotics to
Helicobacter pylori eradication treatment is increasing in recent years. The authors investigated
the effect of quadruple treatment with Saccharomyces boulardii or Lactobacillus reuteri on
the eradication of Helicobacter pylori and side effects of the treatment. They found that
the use of probiotic supplements containing S. boulardii or Lactobacillus reuteri improved
the eradication rate of Helicobacter pylori infection, but it was not statistically significant.
S. boulardii supplements could significantly reduce some side effects of Helicobacter pylori
eradication therapy.
There are some problems:
Why all the subjects continued to take proton pump inhibitor (PPI) alone for 14 days after
eradication treatment?
Did all patients complete post-treatment follow-up? No lost patients? Is there any patient who
did not complete the treatment due to adverse reactions?
One limitation of this study is the small sample size.
Please review this paper.
user
Title: Investigating the Effect of Quadruple Therapy with Saccharomyces Boulardii or
Lactobacillus Reuteri Strain (DSMZ 17648) Supplements on Eradication of Helicobacter Pylori
and Treatments# Adverse effects: A Double-Blind Placebo-Controlled Randomized Clinical
Trial
Version: 2 Date: 13 Nov 2021
Reviewer's report:
The resistance of Helicobacter pylori to antibiotics leads to its eradication rate decreasing year
by year. Combined application of antibiotics can improve the curative effect. The combined use
of antibiotics increased the incidence of adverse reactions. The research on adding probiotics to
Helicobacter pylori eradication treatment is increasing in recent years. The authors investigated
the effect of quadruple treatment with Saccharomyces boulardii or Lactobacillus reuteri on
the eradication of Helicobacter pylori and side effects of the treatment. They found that
the use of probiotic supplements containing S. boulardii or Lactobacillus reuteri improved
the eradication rate of Helicobacter pylori infection, but it was not statistically significant.
S. boulardii supplements could significantly reduce some side effects of Helicobacter pylori
eradication therapy.
There are some problems:
Why all the subjects continued to take proton pump inhibitor (PPI) alone for 14 days after
eradication treatment?
Did all patients complete post-treatment follow-up? No lost patients? Is there any patient who
did not complete the treatment due to adverse reactions?
One limitation of this study is the small sample size.
assistant