Title: Association between wet-bulb globe temperature with peptic ulcer disease in different
geographic regions in a large Taiwanese population study
Version: 2 Date: 19 Feb 2025
Reviewer's report:
Thank you for the opportunity to review this revised manuscript. The authors utilized data from
the Taiwan Biobank to investigate the association between temperature and peptic ulcer disease.
The responses to previous comments are generally satisfactory, and the manuscript is well-
written. The dataset, study design, and modeling strategies appropriately support the research
objectives. I appreciate the authors’ efforts. I have the following major comments for the editors
and authors to consider:
1, The health effects of ambient temperature are typically non-linear, which is why previous
studies have employed non-linear models to assess these impacts. In this study, however,
temperature was modeled as a linear variable, with results presented as the risk per unit increase.
It would be beneficial for the authors to provide a stronger justification for this approach or, at
the very least, acknowledge its limitations.
2, The Taiwan Biobank is an excellent and valuable dataset, containing comprehensive
information on lifestyle factors, sociodemographics, and even genetic data. I am vert interested
in this dataset. Given the richness of this dataset, there is significant potential for a more in-
depth investigation, including mechanistic insights that could enhance the study's contribution
to the field.
Title: Association between wet-bulb globe temperature with peptic ulcer disease in different
geographic regions in a large Taiwanese population study
Version: 2 Date: 19 Feb 2025
Reviewer's report:
Thank you for the opportunity to review this revised manuscript. The authors utilized data from
the Taiwan Biobank to investigate the association between temperature and peptic ulcer disease.
The responses to previous comments are generally satisfactory, and the manuscript is well-
written. The dataset, study design, and modeling strategies appropriately support the research
objectives. I appreciate the authors’ efforts. I have the following major comments for the editors
and authors to consider:
1, The health effects of ambient temperature are typically non-linear, which is why previous
studies have employed non-linear models to assess these impacts. In this study, however,
temperature was modeled as a linear variable, with results presented as the risk per unit increase.
It would be beneficial for the authors to provide a stronger justification for this approach or, at
the very least, acknowledge its limitations.
2, The Taiwan Biobank is an excellent and valuable dataset, containing comprehensive
information on lifestyle factors, sociodemographics, and even genetic data. I am vert interested
in this dataset. Given the richness of this dataset, there is significant potential for a more in-
depth investigation, including mechanistic insights that could enhance the study's contribution
to the field.
Please review this paper.
user
Title: Association between wet-bulb globe temperature with peptic ulcer disease in different
geographic regions in a large Taiwanese population study
Version: 2 Date: 19 Feb 2025
Reviewer's report:
Thank you for the opportunity to review this revised manuscript. The authors utilized data from
the Taiwan Biobank to investigate the association between temperature and peptic ulcer disease.
The responses to previous comments are generally satisfactory, and the manuscript is well-
written. The dataset, study design, and modeling strategies appropriately support the research
objectives. I appreciate the authors’ efforts. I have the following major comments for the editors
and authors to consider:
1, The health effects of ambient temperature are typically non-linear, which is why previous
studies have employed non-linear models to assess these impacts. In this study, however,
temperature was modeled as a linear variable, with results presented as the risk per unit increase.
It would be beneficial for the authors to provide a stronger justification for this approach or, at
the very least, acknowledge its limitations.
2, The Taiwan Biobank is an excellent and valuable dataset, containing comprehensive
information on lifestyle factors, sociodemographics, and even genetic data. I am vert interested
in this dataset. Given the richness of this dataset, there is significant potential for a more in-
depth investigation, including mechanistic insights that could enhance the study's contribution
to the field.
assistant