Reviewer's report
Title:Genetic risk factors for intestinal metaplasia in a high risk
Singapore-Chinese population: a cohort study
Version: 2Date:21 August 2009
Reviewer: Nobuyuki Hamajima
Reviewer's report:
I understand the responses except the below two points.
Major Compulsory Revisions
1. The authors responsed that the p-value of HWE was >0.05, but it is 0.015 for
IL10 -819T/C (186, 124, and 38), and <0.001 for NQO1 609C/T, based on the
figures in Table 3. Both showed a significant finding. Are the authors sure that
the genotyping was correct?
2. As the authors stated "there is a high probability that IM+ subjects had HP
infection at some stage", the analysis for the infected (IM+ or HP+) is also
requested.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Genetic risk factors for intestinal metaplasia in a high risk
Singapore-Chinese population: a cohort study
Version: 2Date:21 August 2009
Reviewer: Nobuyuki Hamajima
Reviewer's report:
I understand the responses except the below two points.
Major Compulsory Revisions
1. The authors responsed that the p-value of HWE was >0.05, but it is 0.015 for
IL10 -819T/C (186, 124, and 38), and <0.001 for NQO1 609C/T, based on the
figures in Table 3. Both showed a significant finding. Are the authors sure that
the genotyping was correct?
2. As the authors stated "there is a high probability that IM+ subjects had HP
infection at some stage", the analysis for the infected (IM+ or HP+) is also
requested.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Genetic risk factors for intestinal metaplasia in a high risk
Singapore-Chinese population: a cohort study
Version: 2Date:21 August 2009
Reviewer: Nobuyuki Hamajima
Reviewer's report:
I understand the responses except the below two points.
Major Compulsory Revisions
1. The authors responsed that the p-value of HWE was >0.05, but it is 0.015 for
IL10 -819T/C (186, 124, and 38), and <0.001 for NQO1 609C/T, based on the
figures in Table 3. Both showed a significant finding. Are the authors sure that
the genotyping was correct?
2. As the authors stated "there is a high probability that IM+ subjects had HP
infection at some stage", the analysis for the infected (IM+ or HP+) is also
requested.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant