Title: Fecal Microbiota Profiling in Irritable Bowel Syndrome and Inflammatory Bowel Disease
Patients with Irritable Bowel Syndrome-Type Symptoms
Version: 2 Date: 22 Jun 2021
Reviewer's report:
I carefully reviewed the manuscript by Cui et al.
The paper is interesting and well written.
However, it could be improved:
1) in the abstract the authors stated that IBS patients were diagnosed according to Rome IV
criteria, but in the main text they indicated Rome III criteria with regard for IBS patients and
Rome IV for IBD-IBS patients. I think that the same criteria should be used for every cohort
including IBS patients.
2) Fecal calprotectin levels should be assessed in order to evaluate remission of IBD patients,
especially in case of the concomitant presence of IBS symptoms, which could be confused with
an IBD flare
3) Dietary habits could modify intestinal microbiota. It is necessary to indicate what advices
were given to patients in order to avoid modifications related to diet.
Title: Fecal Microbiota Profiling in Irritable Bowel Syndrome and Inflammatory Bowel Disease
Patients with Irritable Bowel Syndrome-Type Symptoms
Version: 2 Date: 22 Jun 2021
Reviewer's report:
I carefully reviewed the manuscript by Cui et al.
The paper is interesting and well written.
However, it could be improved:
1) in the abstract the authors stated that IBS patients were diagnosed according to Rome IV
criteria, but in the main text they indicated Rome III criteria with regard for IBS patients and
Rome IV for IBD-IBS patients. I think that the same criteria should be used for every cohort
including IBS patients.
2) Fecal calprotectin levels should be assessed in order to evaluate remission of IBD patients,
especially in case of the concomitant presence of IBS symptoms, which could be confused with
an IBD flare
3) Dietary habits could modify intestinal microbiota. It is necessary to indicate what advices
were given to patients in order to avoid modifications related to diet.
Please review this paper.
user
Title: Fecal Microbiota Profiling in Irritable Bowel Syndrome and Inflammatory Bowel Disease
Patients with Irritable Bowel Syndrome-Type Symptoms
Version: 2 Date: 22 Jun 2021
Reviewer's report:
I carefully reviewed the manuscript by Cui et al.
The paper is interesting and well written.
However, it could be improved:
1) in the abstract the authors stated that IBS patients were diagnosed according to Rome IV
criteria, but in the main text they indicated Rome III criteria with regard for IBS patients and
Rome IV for IBD-IBS patients. I think that the same criteria should be used for every cohort
including IBS patients.
2) Fecal calprotectin levels should be assessed in order to evaluate remission of IBD patients,
especially in case of the concomitant presence of IBS symptoms, which could be confused with
an IBD flare
3) Dietary habits could modify intestinal microbiota. It is necessary to indicate what advices
were given to patients in order to avoid modifications related to diet.
assistant