Title: Exploring the association between life’s essential 8 and gallstone disease in the US adult
population: a population-based study utilizing NHANES data from 2017-2018
Version: 4 Date: 28 Oct 2024
Reviewer's report:
Recommendations for the authors:
1. Why both Chi-square and Fisher's test? the latter is used only for small samples with an
expected frequency less than 5.
2. Why did the authors did not consider taking NAFLD as a covariate?
3.  Glucose levels can be normal if there is insulin resistance and hyperinsulinemia in obese
individuals.
4. Also HS-CRP could be a potential covariate.
5. Instead of Cardiovascular disease and hypertension, indicators like vascular rigidity and
endothelial dysfunction would have been more promising.
6. I think this score has very low power of prediction. The authors should elaborate a new one
or adjust the present one.
7. Why the authors chose the  lowest tertial as a reference group?  How were the cut-points
established?
Title: Exploring the association between life’s essential 8 and gallstone disease in the US adult
population: a population-based study utilizing NHANES data from 2017-2018
Version: 4 Date: 28 Oct 2024
Reviewer's report:
Recommendations for the authors:
1. Why both Chi-square and Fisher's test? the latter is used only for small samples with an
expected frequency less than 5.
2. Why did the authors did not consider taking NAFLD as a covariate?
3.  Glucose levels can be normal if there is insulin resistance and hyperinsulinemia in obese
individuals.
4. Also HS-CRP could be a potential covariate.
5. Instead of Cardiovascular disease and hypertension, indicators like vascular rigidity and
endothelial dysfunction would have been more promising.
6. I think this score has very low power of prediction. The authors should elaborate a new one
or adjust the present one.
7. Why the authors chose the  lowest tertial as a reference group?  How were the cut-points
established?
Please review this paper.
user
Title: Exploring the association between life’s essential 8 and gallstone disease in the US adult
population: a population-based study utilizing NHANES data from 2017-2018
Version: 4 Date: 28 Oct 2024
Reviewer's report:
Recommendations for the authors:
1. Why both Chi-square and Fisher's test? the latter is used only for small samples with an
expected frequency less than 5.
2. Why did the authors did not consider taking NAFLD as a covariate?
3.  Glucose levels can be normal if there is insulin resistance and hyperinsulinemia in obese
individuals.
4. Also HS-CRP could be a potential covariate.
5. Instead of Cardiovascular disease and hypertension, indicators like vascular rigidity and
endothelial dysfunction would have been more promising.
6. I think this score has very low power of prediction. The authors should elaborate a new one
or adjust the present one.
7. Why the authors chose the  lowest tertial as a reference group?  How were the cut-points
established?
assistant