Reviewer ’s report  
 
Title: An updated overview of spectrum of Gluten -related disorders: clinical and diagnostic  
aspects  
 
Version: 0 Date: 28 Apr 2020  
 
Reviewer: Massimo Bellini  
 
Reviewer's report:  
 
The paper deals with all related gluten pathologies, describing adequately clinical characteristics, 
diagnosis and therapy for each of these conditions  
These disorders are widespread and they represent a topic of increasing interest from the medical 
point  of view.  
The review is really very complete and detailed.  
The authors should add an initial chapter in which the possible hypotheses of the increase of the 
related gluten disorders are discussed (e.g. increased consumption of gluten? Intensive 
cultivation ? Use of different grains than in the past?)  
 
 
Qualit y of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years rece ived reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way  gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or s alary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can a nswer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my rep ort to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creat ive Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: An updated overview of spectrum of Gluten -related disorders: clinical and diagnostic  
aspects  
 
Version: 0 Date: 28 Apr 2020  
 
Reviewer: Massimo Bellini  
 
Reviewer's report:  
 
The paper deals with all related gluten pathologies, describing adequately clinical characteristics, 
diagnosis and therapy for each of these conditions  
These disorders are widespread and they represent a topic of increasing interest from the medical 
point  of view.  
The review is really very complete and detailed.  
The authors should add an initial chapter in which the possible hypotheses of the increase of the 
related gluten disorders are discussed (e.g. increased consumption of gluten? Intensive 
cultivation ? Use of different grains than in the past?)  
 
 
Qualit y of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years rece ived reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way  gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or s alary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can a nswer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my rep ort to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creat ive Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: An updated overview of spectrum of Gluten -related disorders: clinical and diagnostic  
aspects  
 
Version: 0 Date: 28 Apr 2020  
 
Reviewer: Massimo Bellini  
 
Reviewer's report:  
 
The paper deals with all related gluten pathologies, describing adequately clinical characteristics, 
diagnosis and therapy for each of these conditions  
These disorders are widespread and they represent a topic of increasing interest from the medical 
point  of view.  
The review is really very complete and detailed.  
The authors should add an initial chapter in which the possible hypotheses of the increase of the 
related gluten disorders are discussed (e.g. increased consumption of gluten? Intensive 
cultivation ? Use of different grains than in the past?)  
 
 
Qualit y of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years rece ived reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way  gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or s alary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can a nswer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my rep ort to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creat ive Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant