Title: Aggregate index of systemic inflammation tied to increased fatty liver disease risk:
insights from NHANES data
Version: 2 Date: 06 Apr 2025
Reviewer:  Hyungjune Ku
Reviewer's report:
My primary concern is the potential of the selection bias  in this study. The clinical guideline
may differ between nations and even institutions. But generally, patients with higher probability
of having FLD is more prone to undergo fibroscan. Therefore, the studied population after
application of exclusion criteria which excluded significant portion of sample patients due to
missing CAP data may have brought bias to the results of the study.
Although, I understand that this is inevitable to some extent due to the retrospective nature of
the study design. However, since the size of the excluded sample population is so large, it is
worth mentioning this in the maunscript for the minor revision.
Title: Aggregate index of systemic inflammation tied to increased fatty liver disease risk:
insights from NHANES data
Version: 2 Date: 06 Apr 2025
Reviewer:  Hyungjune Ku
Reviewer's report:
My primary concern is the potential of the selection bias  in this study. The clinical guideline
may differ between nations and even institutions. But generally, patients with higher probability
of having FLD is more prone to undergo fibroscan. Therefore, the studied population after
application of exclusion criteria which excluded significant portion of sample patients due to
missing CAP data may have brought bias to the results of the study.
Although, I understand that this is inevitable to some extent due to the retrospective nature of
the study design. However, since the size of the excluded sample population is so large, it is
worth mentioning this in the maunscript for the minor revision.
Please review this paper.
user
Title: Aggregate index of systemic inflammation tied to increased fatty liver disease risk:
insights from NHANES data
Version: 2 Date: 06 Apr 2025
Reviewer:  Hyungjune Ku
Reviewer's report:
My primary concern is the potential of the selection bias  in this study. The clinical guideline
may differ between nations and even institutions. But generally, patients with higher probability
of having FLD is more prone to undergo fibroscan. Therefore, the studied population after
application of exclusion criteria which excluded significant portion of sample patients due to
missing CAP data may have brought bias to the results of the study.
Although, I understand that this is inevitable to some extent due to the retrospective nature of
the study design. However, since the size of the excluded sample population is so large, it is
worth mentioning this in the maunscript for the minor revision.
assistant