Title: Comparative Serum Imidazole Propionate Profiling in Colorectal Adenoma and Cancer
by UPLC-MS/MS
Version: 1 Date: 28 Apr 2025
Reviewer:  Makoto Ooi
Reviewer's report:
Thank you for your prompt and current corrections.
The corrections have been made in line with most of the suggestions, but please confirm the
following two points.
1) In the discussion section, you mention other diseases and Imp concentrations, but this includes
concentrations in serum and other concentrations (such as in tissues). Since this study is on
serum, please clearly state what samples were used for each measurement when citing.
2) In the induction section, you mention the economics, so please explain how much more cost-
effective this method is than existing methods.
Title: Comparative Serum Imidazole Propionate Profiling in Colorectal Adenoma and Cancer
by UPLC-MS/MS
Version: 1 Date: 28 Apr 2025
Reviewer:  Makoto Ooi
Reviewer's report:
Thank you for your prompt and current corrections.
The corrections have been made in line with most of the suggestions, but please confirm the
following two points.
1) In the discussion section, you mention other diseases and Imp concentrations, but this includes
concentrations in serum and other concentrations (such as in tissues). Since this study is on
serum, please clearly state what samples were used for each measurement when citing.
2) In the induction section, you mention the economics, so please explain how much more cost-
effective this method is than existing methods.
Please review this paper.
user
Title: Comparative Serum Imidazole Propionate Profiling in Colorectal Adenoma and Cancer
by UPLC-MS/MS
Version: 1 Date: 28 Apr 2025
Reviewer:  Makoto Ooi
Reviewer's report:
Thank you for your prompt and current corrections.
The corrections have been made in line with most of the suggestions, but please confirm the
following two points.
1) In the discussion section, you mention other diseases and Imp concentrations, but this includes
concentrations in serum and other concentrations (such as in tissues). Since this study is on
serum, please clearly state what samples were used for each measurement when citing.
2) In the induction section, you mention the economics, so please explain how much more cost-
effective this method is than existing methods.
assistant