Reviewer's report
Title:Fingertip rapid point-of-care test in adult case-finding in coeliac disease
Version: 2Date:24 April 2013
Reviewer: Parveen June Kumar
Reviewer's report:
An interesting article showing that the rapid 'point of care test' is a useful test for
finding cases in patients,. The authors have tested this in first degree relatives of
patients with Coeliac disease .
1. The numbers are too small for any statistical analysis. Larger population
studies will be needed for confirmation.
2. Direct translation from other languages into English does not always result in
the correct meaning. I have tried to suggest different sentences to help
clarification.
ABSTRACT
3. Background: Suggest changing to : Coeliac disease(CD), due to its protean
clinical manifestation, is still very under diagnosed in adults, and delays in
diagnosis may take years or even decades. Simple tools to find cases in primary
care may help to identify patients for further diagnostic tests. We have evaluated
the usefulness.........
4. Methods: .....delete 'altogether'
5. 2nd para English here ... Change to: In addition...the .POCT(which measures
blood erythrocytes...complexes ) on site, blood was drawn ( you cant draw serum
from the blood!)
6. 4th sentence: Change sentence to read to 'All serological parameters were
analysed blind in a centralised laboratory...
7. Results:2nd sentence Change to : A positive EMA test was found only in one
other subject.
8. BACKGROUND Rather long
6th sentence.An odd statement ...'coeliac disease is no longer confined to the
childhood population....' This implies that we have only recently discovered it in
adults!! Change or delete.
9. 2nd para 2nd sentence - please clarify. Do you mean 'multifaceted' or
'multifactorial'...I don't think either is helpful here.Again 'protean manifestation
might be better.
METHODS.
10 Patients. Delete 'Altogether'
11 Endoscopies and biopsies. I suggest that you remove the last 2 sentences
about looking for mucosal TG2 deposits as it is not mentioned in the abstract and
you are getting down to very few numbers (5). Please also remove from the table
and anywhere else mentioned ( results - 2nd para, and discussion)
Results - OK
Discussion
12. Good but extremely long. This should be shortened and points made much
clearer. I think your readers might resent the sentence which says 'It must be
remembered that in biology we never reach 100%'!
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Fingertip rapid point-of-care test in adult case-finding in coeliac disease
Version: 2Date:24 April 2013
Reviewer: Parveen June Kumar
Reviewer's report:
An interesting article showing that the rapid 'point of care test' is a useful test for
finding cases in patients,. The authors have tested this in first degree relatives of
patients with Coeliac disease .
1. The numbers are too small for any statistical analysis. Larger population
studies will be needed for confirmation.
2. Direct translation from other languages into English does not always result in
the correct meaning. I have tried to suggest different sentences to help
clarification.
ABSTRACT
3. Background: Suggest changing to : Coeliac disease(CD), due to its protean
clinical manifestation, is still very under diagnosed in adults, and delays in
diagnosis may take years or even decades. Simple tools to find cases in primary
care may help to identify patients for further diagnostic tests. We have evaluated
the usefulness.........
4. Methods: .....delete 'altogether'
5. 2nd para English here ... Change to: In addition...the .POCT(which measures
blood erythrocytes...complexes ) on site, blood was drawn ( you cant draw serum
from the blood!)
6. 4th sentence: Change sentence to read to 'All serological parameters were
analysed blind in a centralised laboratory...
7. Results:2nd sentence Change to : A positive EMA test was found only in one
other subject.
8. BACKGROUND Rather long
6th sentence.An odd statement ...'coeliac disease is no longer confined to the
childhood population....' This implies that we have only recently discovered it in
adults!! Change or delete.
9. 2nd para 2nd sentence - please clarify. Do you mean 'multifaceted' or
'multifactorial'...I don't think either is helpful here.Again 'protean manifestation
might be better.
METHODS.
10 Patients. Delete 'Altogether'
11 Endoscopies and biopsies. I suggest that you remove the last 2 sentences
about looking for mucosal TG2 deposits as it is not mentioned in the abstract and
you are getting down to very few numbers (5). Please also remove from the table
and anywhere else mentioned ( results - 2nd para, and discussion)
Results - OK
Discussion
12. Good but extremely long. This should be shortened and points made much
clearer. I think your readers might resent the sentence which says 'It must be
remembered that in biology we never reach 100%'!
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Fingertip rapid point-of-care test in adult case-finding in coeliac disease
Version: 2Date:24 April 2013
Reviewer: Parveen June Kumar
Reviewer's report:
An interesting article showing that the rapid 'point of care test' is a useful test for
finding cases in patients,. The authors have tested this in first degree relatives of
patients with Coeliac disease .
1. The numbers are too small for any statistical analysis. Larger population
studies will be needed for confirmation.
2. Direct translation from other languages into English does not always result in
the correct meaning. I have tried to suggest different sentences to help
clarification.
ABSTRACT
3. Background: Suggest changing to : Coeliac disease(CD), due to its protean
clinical manifestation, is still very under diagnosed in adults, and delays in
diagnosis may take years or even decades. Simple tools to find cases in primary
care may help to identify patients for further diagnostic tests. We have evaluated
the usefulness.........
4. Methods: .....delete 'altogether'
5. 2nd para English here ... Change to: In addition...the .POCT(which measures
blood erythrocytes...complexes ) on site, blood was drawn ( you cant draw serum
from the blood!)
6. 4th sentence: Change sentence to read to 'All serological parameters were
analysed blind in a centralised laboratory...
7. Results:2nd sentence Change to : A positive EMA test was found only in one
other subject.
8. BACKGROUND Rather long
6th sentence.An odd statement ...'coeliac disease is no longer confined to the
childhood population....' This implies that we have only recently discovered it in
adults!! Change or delete.
9. 2nd para 2nd sentence - please clarify. Do you mean 'multifaceted' or
'multifactorial'...I don't think either is helpful here.Again 'protean manifestation
might be better.
METHODS.
10 Patients. Delete 'Altogether'
11 Endoscopies and biopsies. I suggest that you remove the last 2 sentences
about looking for mucosal TG2 deposits as it is not mentioned in the abstract and
you are getting down to very few numbers (5). Please also remove from the table
and anywhere else mentioned ( results - 2nd para, and discussion)
Results - OK
Discussion
12. Good but extremely long. This should be shortened and points made much
clearer. I think your readers might resent the sentence which says 'It must be
remembered that in biology we never reach 100%'!
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant