Reviewer ’s report  
 
Title: The association between disease activity and patient -reported outcomes in patients with 
moderate -to-severe ulcerative colitis in the United States and Europe  
 
Version: 0 Date: 05 Nov 2019  
 
Reviewer: Joerg Edelmann  
 
Reviewer's report:  
 
The two remission groups (" Deep Remission" vs. "Remission") show few differences, ma ybe 
because of a potential bias as patients without Endoscopy were considered as "Remission", and 
not "Deep remession".  It would be interesting to conduct a Analysis putting the both Remission 
groups together and compare with active disease Group.  
 
The T reatment history of the patients was not included in the Analysis, althoug availabel in 
database.  
 
Potential bias, as all available Outcome data was used, even if the patients did not have 
completed Data on all Outcomes.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscr ipt or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what as pects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written E nglish  
Please indicate the quality of language in the manuscript:  
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimburse ments, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation that may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the  manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my nam e will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as  confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: The association between disease activity and patient -reported outcomes in patients with 
moderate -to-severe ulcerative colitis in the United States and Europe  
 
Version: 0 Date: 05 Nov 2019  
 
Reviewer: Joerg Edelmann  
 
Reviewer's report:  
 
The two remission groups (" Deep Remission" vs. "Remission") show few differences, ma ybe 
because of a potential bias as patients without Endoscopy were considered as "Remission", and 
not "Deep remession".  It would be interesting to conduct a Analysis putting the both Remission 
groups together and compare with active disease Group.  
 
The T reatment history of the patients was not included in the Analysis, althoug availabel in 
database.  
 
Potential bias, as all available Outcome data was used, even if the patients did not have 
completed Data on all Outcomes.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscr ipt or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what as pects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written E nglish  
Please indicate the quality of language in the manuscript:  
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimburse ments, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation that may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the  manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my nam e will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as  confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: The association between disease activity and patient -reported outcomes in patients with 
moderate -to-severe ulcerative colitis in the United States and Europe  
 
Version: 0 Date: 05 Nov 2019  
 
Reviewer: Joerg Edelmann  
 
Reviewer's report:  
 
The two remission groups (" Deep Remission" vs. "Remission") show few differences, ma ybe 
because of a potential bias as patients without Endoscopy were considered as "Remission", and 
not "Deep remession".  It would be interesting to conduct a Analysis putting the both Remission 
groups together and compare with active disease Group.  
 
The T reatment history of the patients was not included in the Analysis, althoug availabel in 
database.  
 
Potential bias, as all available Outcome data was used, even if the patients did not have 
completed Data on all Outcomes.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscr ipt or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what as pects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written E nglish  
Please indicate the quality of language in the manuscript:  
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimburse ments, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organisation that may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the  manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my nam e will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as  confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant