Reviewer's report
Title:Coexistence of HBsAg and anti-HBsAg in a HBeAg positive chronic
hepatitis B difficult-to-treat, wild type for mutations in rt and HBsAg ORFs: loss of
HBsAg with a combination of entecavir plus tenofovir.
Version:2Date:3 March 2014
Reviewer: Samad Amini-Bavil-Olyaee
Reviewer's report:
Galati et al. reported a CHB patient with coexistence of HBsAg and anti-HBs
antibody. The case was subjected for treatment by different anti-HBV agents for
five years and finally sero-converted to anti-HBe antibody and loss of HBsAg
despite having no notable mutation at the Pol and HBsAg region. The case is
interesting and relevant and would be valuable to be considered for publication
as Case Report in the journal. Only few minor concerns should be addressed by
the authors as minor revision.
1- Please indicate the protective value of anti-HBs and please add which kit was
used to quantify this variable.
2- UI or IU, which one is correct, please makes sure to use the correct format in
the entire of the manuscript.
3- Please add the serological and virological information of the patient from 2003
to the Figure 1.
4- Please use the standard format to present mutational pattern in the table 1
e.g. rtG52A, or sG43A.
5- In the first line of the case report, it is mentioned that the patient was admitted
to “our” hospital. Please exactly indicate which hospital and where.
6- Have any family member of the patients diagnosed by HBV infection?
7- If biochemical data is available for all time-points (especially serum ALT level),
should be added to the Figure 1.
8- To me, the title is too long and complex and it would be better to be
summarized.
Note to AE: I would suggest “Minor Revision”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Coexistence of HBsAg and anti-HBsAg in a HBeAg positive chronic
hepatitis B difficult-to-treat, wild type for mutations in rt and HBsAg ORFs: loss of
HBsAg with a combination of entecavir plus tenofovir.
Version:2Date:3 March 2014
Reviewer: Samad Amini-Bavil-Olyaee
Reviewer's report:
Galati et al. reported a CHB patient with coexistence of HBsAg and anti-HBs
antibody. The case was subjected for treatment by different anti-HBV agents for
five years and finally sero-converted to anti-HBe antibody and loss of HBsAg
despite having no notable mutation at the Pol and HBsAg region. The case is
interesting and relevant and would be valuable to be considered for publication
as Case Report in the journal. Only few minor concerns should be addressed by
the authors as minor revision.
1- Please indicate the protective value of anti-HBs and please add which kit was
used to quantify this variable.
2- UI or IU, which one is correct, please makes sure to use the correct format in
the entire of the manuscript.
3- Please add the serological and virological information of the patient from 2003
to the Figure 1.
4- Please use the standard format to present mutational pattern in the table 1
e.g. rtG52A, or sG43A.
5- In the first line of the case report, it is mentioned that the patient was admitted
to “our” hospital. Please exactly indicate which hospital and where.
6- Have any family member of the patients diagnosed by HBV infection?
7- If biochemical data is available for all time-points (especially serum ALT level),
should be added to the Figure 1.
8- To me, the title is too long and complex and it would be better to be
summarized.
Note to AE: I would suggest “Minor Revision”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Coexistence of HBsAg and anti-HBsAg in a HBeAg positive chronic
hepatitis B difficult-to-treat, wild type for mutations in rt and HBsAg ORFs: loss of
HBsAg with a combination of entecavir plus tenofovir.
Version:2Date:3 March 2014
Reviewer: Samad Amini-Bavil-Olyaee
Reviewer's report:
Galati et al. reported a CHB patient with coexistence of HBsAg and anti-HBs
antibody. The case was subjected for treatment by different anti-HBV agents for
five years and finally sero-converted to anti-HBe antibody and loss of HBsAg
despite having no notable mutation at the Pol and HBsAg region. The case is
interesting and relevant and would be valuable to be considered for publication
as Case Report in the journal. Only few minor concerns should be addressed by
the authors as minor revision.
1- Please indicate the protective value of anti-HBs and please add which kit was
used to quantify this variable.
2- UI or IU, which one is correct, please makes sure to use the correct format in
the entire of the manuscript.
3- Please add the serological and virological information of the patient from 2003
to the Figure 1.
4- Please use the standard format to present mutational pattern in the table 1
e.g. rtG52A, or sG43A.
5- In the first line of the case report, it is mentioned that the patient was admitted
to “our” hospital. Please exactly indicate which hospital and where.
6- Have any family member of the patients diagnosed by HBV infection?
7- If biochemical data is available for all time-points (especially serum ALT level),
should be added to the Figure 1.
8- To me, the title is too long and complex and it would be better to be
summarized.
Note to AE: I would suggest “Minor Revision”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant