Reviewer ’s report  
 
Title: Protruded duodenal tumor arising from Santorini ’s duct of the pancreas: a rare case  of 
intraductal papillary mucinous neoplasm mimicking a duodenal polypoid tumor.  
 
Version: 0 Date: 25 Apr 2020  
 
Reviewer's report:  
 
 This article showed intraductal papillary -mucinous adenoma arising from the Santrini's duct 
and this is a rare case and worth reporting. In addition, this case report included detailed clinical 
course and sufficient discussions. However, this manuscript will be better if it is revised 
according to my  suggestion. My suggestion is below:  
 
1. In the title of this manuscript, "intraductal papillary mucinous neoplasm" would be 
better rather than "intraductal papillary neoplasm".   
2. How about was the pathological subtype of IPMN in this case? The subtype of IPMN 
would be important to elucidate clinicopathological characteristics after case accumulation. 
Therefore, it should be added in the manuscript.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
Declaration of competing interests  
Please complete a declaration of competing interest s, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the fut ure? 
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents relating to the cont ent 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you hav e any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no compet ing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand t hat any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Protruded duodenal tumor arising from Santorini ’s duct of the pancreas: a rare case  of 
intraductal papillary mucinous neoplasm mimicking a duodenal polypoid tumor.  
 
Version: 0 Date: 25 Apr 2020  
 
Reviewer's report:  
 
 This article showed intraductal papillary -mucinous adenoma arising from the Santrini's duct 
and this is a rare case and worth reporting. In addition, this case report included detailed clinical 
course and sufficient discussions. However, this manuscript will be better if it is revised 
according to my  suggestion. My suggestion is below:  
 
1. In the title of this manuscript, "intraductal papillary mucinous neoplasm" would be 
better rather than "intraductal papillary neoplasm".   
2. How about was the pathological subtype of IPMN in this case? The subtype of IPMN 
would be important to elucidate clinicopathological characteristics after case accumulation. 
Therefore, it should be added in the manuscript.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
Declaration of competing interests  
Please complete a declaration of competing interest s, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the fut ure? 
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents relating to the cont ent 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you hav e any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no compet ing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand t hat any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Protruded duodenal tumor arising from Santorini ’s duct of the pancreas: a rare case  of 
intraductal papillary mucinous neoplasm mimicking a duodenal polypoid tumor.  
 
Version: 0 Date: 25 Apr 2020  
 
Reviewer's report:  
 
 This article showed intraductal papillary -mucinous adenoma arising from the Santrini's duct 
and this is a rare case and worth reporting. In addition, this case report included detailed clinical 
course and sufficient discussions. However, this manuscript will be better if it is revised 
according to my  suggestion. My suggestion is below:  
 
1. In the title of this manuscript, "intraductal papillary mucinous neoplasm" would be 
better rather than "intraductal papillary neoplasm".   
2. How about was the pathological subtype of IPMN in this case? The subtype of IPMN 
would be important to elucidate clinicopathological characteristics after case accumulation. 
Therefore, it should be added in the manuscript.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
Declaration of competing interests  
Please complete a declaration of competing interest s, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the fut ure? 
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents relating to the cont ent 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you hav e any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no compet ing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand t hat any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant