Reviewer's report
Title:Two cases of monomicrobial intrabdominal abscesses due to KPC- 3
Klebsiella pneumoniae ST258 clone
Version: 2Date:24 June 2011
Reviewer: Maria Souli
Reviewer's report:
This is a case report describing 2 similar cases of intra-abdominal abscess due
to KPC-3 producing K.pneumoniae. The clinical presentation, diagnostic
evaluation and management of these cases were straightforward. Nevertheless,
the etiologic agent was an emerging pathogen, a carbapenemase producing
K.pneumoniae. In some geographical areas where KPC producers are prevalent
these cases would have been very commonly encountered but in areas where
these pathogens are still rare, these cases would have been unexpected and
worthing publication and underline the need for a microbiological diagnosis.
Minor Essential Revisions
The authors should clarify that the combination regimen used was arbitrary since
there are no clinical studies suggesting that colistin and tigecycline combination
has superior in vivo activity as compared to either agent alone nor they have
confirmed a failure of monotherapy in their patients.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Two cases of monomicrobial intrabdominal abscesses due to KPC- 3
Klebsiella pneumoniae ST258 clone
Version: 2Date:24 June 2011
Reviewer: Maria Souli
Reviewer's report:
This is a case report describing 2 similar cases of intra-abdominal abscess due
to KPC-3 producing K.pneumoniae. The clinical presentation, diagnostic
evaluation and management of these cases were straightforward. Nevertheless,
the etiologic agent was an emerging pathogen, a carbapenemase producing
K.pneumoniae. In some geographical areas where KPC producers are prevalent
these cases would have been very commonly encountered but in areas where
these pathogens are still rare, these cases would have been unexpected and
worthing publication and underline the need for a microbiological diagnosis.
Minor Essential Revisions
The authors should clarify that the combination regimen used was arbitrary since
there are no clinical studies suggesting that colistin and tigecycline combination
has superior in vivo activity as compared to either agent alone nor they have
confirmed a failure of monotherapy in their patients.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Two cases of monomicrobial intrabdominal abscesses due to KPC- 3
Klebsiella pneumoniae ST258 clone
Version: 2Date:24 June 2011
Reviewer: Maria Souli
Reviewer's report:
This is a case report describing 2 similar cases of intra-abdominal abscess due
to KPC-3 producing K.pneumoniae. The clinical presentation, diagnostic
evaluation and management of these cases were straightforward. Nevertheless,
the etiologic agent was an emerging pathogen, a carbapenemase producing
K.pneumoniae. In some geographical areas where KPC producers are prevalent
these cases would have been very commonly encountered but in areas where
these pathogens are still rare, these cases would have been unexpected and
worthing publication and underline the need for a microbiological diagnosis.
Minor Essential Revisions
The authors should clarify that the combination regimen used was arbitrary since
there are no clinical studies suggesting that colistin and tigecycline combination
has superior in vivo activity as compared to either agent alone nor they have
confirmed a failure of monotherapy in their patients.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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