Reviewer's report
Title:Longitudinal fluctuations in PD1 and PD-L1 expression in association with
changes in anti-viral immune response in chronic hepatitis B
Version: 3Date:10 June 2012
Reviewer: Christoph Neumann-Haefelin
Reviewer's report:
Major compulsory revisions:
The authors addressed my previous major comments 2+3 satisfactorily, however,
comment 1 was not addressed adequately. I still doubt that figure 1 shows any
pentamer-positive response. A true positive pentamer response is displayed in
Fig. 3B. A suggested in the previous comments, the authors really need to
display a) background staining without pentamer and b) pentamer control
stainings from healthy controls.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Longitudinal fluctuations in PD1 and PD-L1 expression in association with
changes in anti-viral immune response in chronic hepatitis B
Version: 3Date:10 June 2012
Reviewer: Christoph Neumann-Haefelin
Reviewer's report:
Major compulsory revisions:
The authors addressed my previous major comments 2+3 satisfactorily, however,
comment 1 was not addressed adequately. I still doubt that figure 1 shows any
pentamer-positive response. A true positive pentamer response is displayed in
Fig. 3B. A suggested in the previous comments, the authors really need to
display a) background staining without pentamer and b) pentamer control
stainings from healthy controls.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Longitudinal fluctuations in PD1 and PD-L1 expression in association with
changes in anti-viral immune response in chronic hepatitis B
Version: 3Date:10 June 2012
Reviewer: Christoph Neumann-Haefelin
Reviewer's report:
Major compulsory revisions:
The authors addressed my previous major comments 2+3 satisfactorily, however,
comment 1 was not addressed adequately. I still doubt that figure 1 shows any
pentamer-positive response. A true positive pentamer response is displayed in
Fig. 3B. A suggested in the previous comments, the authors really need to
display a) background staining without pentamer and b) pentamer control
stainings from healthy controls.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant