Reviewer's report
Title:Radiofrequency Ablation Following First-Line Transarterial Arterial
Chemoembolization for Patients with Unresectable Hepatocellular Carcinoma
Beyond the Milan Criteria
Version: 2Date:15 August 2013
Reviewer: Hiroyuki Kirikoshi
Reviewer's report:
Comments to Author
Title: Radiofrequency ablation following first-line transarterial arterial
chemoembolization for patients with unresectable hepatocellular carcinoma
beyond the Milan Criteria
Journal: BMC Gastroenterology
Type of article: Research
Authors: Lan Zhang et al.
CLASSIFICATION OF THE MANUSCRIPT
Minor Essential Revisions.
This manuscript described the combination of radiofrequency ablation (RFA) and
transarterial chemoembolization (TACE) therapy for unresectable hepatocellular
carcinoma (HCC) patients beyond the Milan Criteria. This manuscript is clearly
written and easy to read.
MAJOR COMMENTS
The procedure of combination therapy in this manuscript (RFA is performed
within 1-2 months after TACE in patients who has incomplete necrotic tumor
nodules) considered to be unique and reasonable for the effectiveness treatment.
In previous studies including our report (Hepatol Res, 2009; 39: 553-562), RFA
was performed for the all HCC lesions as possible, and performed within 1-2
weeks after TACE expecting for larger tumor necrosis due to cooling effect of
TACE.
MINOR COMMENTS
#1.
There is typos error in the title of the manuscript, “transarterial arterial###”.
#2.
Table 1, 2 and 3 are not found in this PDF file (due to error of computer or
internet?).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Radiofrequency Ablation Following First-Line Transarterial Arterial
Chemoembolization for Patients with Unresectable Hepatocellular Carcinoma
Beyond the Milan Criteria
Version: 2Date:15 August 2013
Reviewer: Hiroyuki Kirikoshi
Reviewer's report:
Comments to Author
Title: Radiofrequency ablation following first-line transarterial arterial
chemoembolization for patients with unresectable hepatocellular carcinoma
beyond the Milan Criteria
Journal: BMC Gastroenterology
Type of article: Research
Authors: Lan Zhang et al.
CLASSIFICATION OF THE MANUSCRIPT
Minor Essential Revisions.
This manuscript described the combination of radiofrequency ablation (RFA) and
transarterial chemoembolization (TACE) therapy for unresectable hepatocellular
carcinoma (HCC) patients beyond the Milan Criteria. This manuscript is clearly
written and easy to read.
MAJOR COMMENTS
The procedure of combination therapy in this manuscript (RFA is performed
within 1-2 months after TACE in patients who has incomplete necrotic tumor
nodules) considered to be unique and reasonable for the effectiveness treatment.
In previous studies including our report (Hepatol Res, 2009; 39: 553-562), RFA
was performed for the all HCC lesions as possible, and performed within 1-2
weeks after TACE expecting for larger tumor necrosis due to cooling effect of
TACE.
MINOR COMMENTS
#1.
There is typos error in the title of the manuscript, “transarterial arterial###”.
#2.
Table 1, 2 and 3 are not found in this PDF file (due to error of computer or
internet?).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Radiofrequency Ablation Following First-Line Transarterial Arterial
Chemoembolization for Patients with Unresectable Hepatocellular Carcinoma
Beyond the Milan Criteria
Version: 2Date:15 August 2013
Reviewer: Hiroyuki Kirikoshi
Reviewer's report:
Comments to Author
Title: Radiofrequency ablation following first-line transarterial arterial
chemoembolization for patients with unresectable hepatocellular carcinoma
beyond the Milan Criteria
Journal: BMC Gastroenterology
Type of article: Research
Authors: Lan Zhang et al.
CLASSIFICATION OF THE MANUSCRIPT
Minor Essential Revisions.
This manuscript described the combination of radiofrequency ablation (RFA) and
transarterial chemoembolization (TACE) therapy for unresectable hepatocellular
carcinoma (HCC) patients beyond the Milan Criteria. This manuscript is clearly
written and easy to read.
MAJOR COMMENTS
The procedure of combination therapy in this manuscript (RFA is performed
within 1-2 months after TACE in patients who has incomplete necrotic tumor
nodules) considered to be unique and reasonable for the effectiveness treatment.
In previous studies including our report (Hepatol Res, 2009; 39: 553-562), RFA
was performed for the all HCC lesions as possible, and performed within 1-2
weeks after TACE expecting for larger tumor necrosis due to cooling effect of
TACE.
MINOR COMMENTS
#1.
There is typos error in the title of the manuscript, “transarterial arterial###”.
#2.
Table 1, 2 and 3 are not found in this PDF file (due to error of computer or
internet?).
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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