Title: Prognostic Role of Multiparameter MRI and radiomics in Progression of
Advanced Unresectable Hepatocellular Carcinoma Following Combined Transcatheter Arterial
Chemoembolization and Lenvatinib Therapy
Version: 2 Date: 30 Nov 2021
Reviewer's report:
The study is interesting and overall well written.
I have the following suggestions to improve the quality and clarity of the paper:
1) Were the accuracy of the models compared? If so, how? I would suggest to express also the
AIC (Akaike information criteria) to express the comparative quality of the models.
2) A calibration curve would be useful to assess the goodness of fit of this model
3) The lack of a proper validation represents a major drawback and it should be assessed as such
in the Discussion
4) Other important limitation is the lack of data on overall survival.....
5) I would recommend to discuss briefly the impact of eventual systemic treatment on PFS after
TACE (in this regard cite the example of regorafenib and the recent paper: PMID: 31877664
and the example of very recent checkpoint inhibitors with the paper: PMID: 33086471)
Title: Prognostic Role of Multiparameter MRI and radiomics in Progression of
Advanced Unresectable Hepatocellular Carcinoma Following Combined Transcatheter Arterial
Chemoembolization and Lenvatinib Therapy
Version: 2 Date: 30 Nov 2021
Reviewer's report:
The study is interesting and overall well written.
I have the following suggestions to improve the quality and clarity of the paper:
1) Were the accuracy of the models compared? If so, how? I would suggest to express also the
AIC (Akaike information criteria) to express the comparative quality of the models.
2) A calibration curve would be useful to assess the goodness of fit of this model
3) The lack of a proper validation represents a major drawback and it should be assessed as such
in the Discussion
4) Other important limitation is the lack of data on overall survival.....
5) I would recommend to discuss briefly the impact of eventual systemic treatment on PFS after
TACE (in this regard cite the example of regorafenib and the recent paper: PMID: 31877664
and the example of very recent checkpoint inhibitors with the paper: PMID: 33086471)
Please review this paper.
user
Title: Prognostic Role of Multiparameter MRI and radiomics in Progression of
Advanced Unresectable Hepatocellular Carcinoma Following Combined Transcatheter Arterial
Chemoembolization and Lenvatinib Therapy
Version: 2 Date: 30 Nov 2021
Reviewer's report:
The study is interesting and overall well written.
I have the following suggestions to improve the quality and clarity of the paper:
1) Were the accuracy of the models compared? If so, how? I would suggest to express also the
AIC (Akaike information criteria) to express the comparative quality of the models.
2) A calibration curve would be useful to assess the goodness of fit of this model
3) The lack of a proper validation represents a major drawback and it should be assessed as such
in the Discussion
4) Other important limitation is the lack of data on overall survival.....
5) I would recommend to discuss briefly the impact of eventual systemic treatment on PFS after
TACE (in this regard cite the example of regorafenib and the recent paper: PMID: 31877664
and the example of very recent checkpoint inhibitors with the paper: PMID: 33086471)
assistant