Title: Establishing of a risk prediction model for metabolic dysfunction associated steatotic liver
disease: a retrospective cohort study
Version: 2 Date: 04 Nov 2024
Reviewer's report:
The auhors present an interesting article suggesting a risk prediciton model for the development
of MASLD in a cohort of non-MASLD patients. The idea is overall well execute, however there
are a few things that need improvement before final publication.
1. English language must be re-checked throughout the manuscript. Examples are: line 49: 'it can
also', 'it' should be substituted with MASLD; line 50: 'along with their incidence and motality'
should be deleted as it is not needed'; line 70: 'those who are 18 years of age or older' should
be sustituted  with age of at least 18 years, etc
2. The results of MASLD in endothelial function leading to inflammation and subsequent
atherosclerosis and CVD should be highlighted in the introduction (ref: doi: 10.1007/
s00018-023-04966-7; doi: 10.3390/cells11162511)
3. In both introduction and discussion, the authors present details about nomograms. This is
unnecessary and the discussion part should be deleted
4. The authors should evaluate their risk prediction model in subgroups of interst, like patiens
with hypertension,  hyperlipidemia and diabetes and note possible differences
5.  Finally, the retrospective status of the study should be added as study limitation
Title: Establishing of a risk prediction model for metabolic dysfunction associated steatotic liver
disease: a retrospective cohort study
Version: 2 Date: 04 Nov 2024
Reviewer's report:
The auhors present an interesting article suggesting a risk prediciton model for the development
of MASLD in a cohort of non-MASLD patients. The idea is overall well execute, however there
are a few things that need improvement before final publication.
1. English language must be re-checked throughout the manuscript. Examples are: line 49: 'it can
also', 'it' should be substituted with MASLD; line 50: 'along with their incidence and motality'
should be deleted as it is not needed'; line 70: 'those who are 18 years of age or older' should
be sustituted  with age of at least 18 years, etc
2. The results of MASLD in endothelial function leading to inflammation and subsequent
atherosclerosis and CVD should be highlighted in the introduction (ref: doi: 10.1007/
s00018-023-04966-7; doi: 10.3390/cells11162511)
3. In both introduction and discussion, the authors present details about nomograms. This is
unnecessary and the discussion part should be deleted
4. The authors should evaluate their risk prediction model in subgroups of interst, like patiens
with hypertension,  hyperlipidemia and diabetes and note possible differences
5.  Finally, the retrospective status of the study should be added as study limitation
Please review this paper.
user
Title: Establishing of a risk prediction model for metabolic dysfunction associated steatotic liver
disease: a retrospective cohort study
Version: 2 Date: 04 Nov 2024
Reviewer's report:
The auhors present an interesting article suggesting a risk prediciton model for the development
of MASLD in a cohort of non-MASLD patients. The idea is overall well execute, however there
are a few things that need improvement before final publication.
1. English language must be re-checked throughout the manuscript. Examples are: line 49: 'it can
also', 'it' should be substituted with MASLD; line 50: 'along with their incidence and motality'
should be deleted as it is not needed'; line 70: 'those who are 18 years of age or older' should
be sustituted  with age of at least 18 years, etc
2. The results of MASLD in endothelial function leading to inflammation and subsequent
atherosclerosis and CVD should be highlighted in the introduction (ref: doi: 10.1007/
s00018-023-04966-7; doi: 10.3390/cells11162511)
3. In both introduction and discussion, the authors present details about nomograms. This is
unnecessary and the discussion part should be deleted
4. The authors should evaluate their risk prediction model in subgroups of interst, like patiens
with hypertension,  hyperlipidemia and diabetes and note possible differences
5.  Finally, the retrospective status of the study should be added as study limitation
assistant