Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 1 Date: 23 Jun 2024
Reviewer's report:
This is a well conducted review that is similar to one undertaken by Mauro Podda et. al "Early
versus delayed defunctioning ileostomy closure after low anterior resection for rectal cancer: a
meta-analysis and trial sequential analysis of safety and functional outcomes". The paper is well
written and advises caution against EC due to risk of increased morbidity. I would suggest that
the discussion could more relevant if focussed on patients by groups i.e. those having resection
without neoadjuvant therapy where complications could delay post operative adjuvant therapy if
necessary and those where EC after neoadjuvant therapy does have possible increased morbidity.
In both groups a cautious approach is relevant and the patient needs counselling about the likely
risks associated with EC given the lack of definite evidence.
I am not sure why the review by Mauro Podda et al is not referenced.
Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 1 Date: 23 Jun 2024
Reviewer's report:
This is a well conducted review that is similar to one undertaken by Mauro Podda et. al "Early
versus delayed defunctioning ileostomy closure after low anterior resection for rectal cancer: a
meta-analysis and trial sequential analysis of safety and functional outcomes". The paper is well
written and advises caution against EC due to risk of increased morbidity. I would suggest that
the discussion could more relevant if focussed on patients by groups i.e. those having resection
without neoadjuvant therapy where complications could delay post operative adjuvant therapy if
necessary and those where EC after neoadjuvant therapy does have possible increased morbidity.
In both groups a cautious approach is relevant and the patient needs counselling about the likely
risks associated with EC given the lack of definite evidence.
I am not sure why the review by Mauro Podda et al is not referenced.
Please review this paper.
user
Title: Post-surgical morbidity in early versus late closure of defunctioning ileostomy after rectal
cancer surgery: A systematic review and meta-analysis of randomised controlled trials
Version: 1 Date: 23 Jun 2024
Reviewer's report:
This is a well conducted review that is similar to one undertaken by Mauro Podda et. al "Early
versus delayed defunctioning ileostomy closure after low anterior resection for rectal cancer: a
meta-analysis and trial sequential analysis of safety and functional outcomes". The paper is well
written and advises caution against EC due to risk of increased morbidity. I would suggest that
the discussion could more relevant if focussed on patients by groups i.e. those having resection
without neoadjuvant therapy where complications could delay post operative adjuvant therapy if
necessary and those where EC after neoadjuvant therapy does have possible increased morbidity.
In both groups a cautious approach is relevant and the patient needs counselling about the likely
risks associated with EC given the lack of definite evidence.
I am not sure why the review by Mauro Podda et al is not referenced.
assistant