Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 2 Date: 13 Oct 2024
Reviewer's report:
I remain unconvinced about the authors' choice to look at ABSI. Although they argue that ABSI
is independent of BMI and present it as a novel measure, they do not provide a compelling
rationale for why it was examined in this study.
Here are the reasons for my continued skepticism:
--The authors have not adequately addressed my earlier question regarding whether there are
any published articles that previously used ABSI. They mentioned that they addressed this on
page 13 but did not cite any. This raises doubts about the practical applicability and broader
acceptance of ABSI (as there are no other previously published papers that used ABSI).
--While the authors show the supposed superiority of ABSI compared to BMI, weight, height,
etc (figure 3), they do not seem to have fully understood my question regarding the model used
to generate the ROC curves. Their response that they used a “pure ROC curve analysis” does
not clarify the methodology, leading me to question the validity of their statistical approach.
Without a clear explanation of the model used to produce the ROC curves, I find it difficult to
trust their AUC results. Also, the lack of knowledge and transparency on their own methodology
used to create the ROC curves raise serious concerns about reproducibility of their results. Also,
the authors should also report 95% confidence interval for these AUCs.
Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 2 Date: 13 Oct 2024
Reviewer's report:
I remain unconvinced about the authors' choice to look at ABSI. Although they argue that ABSI
is independent of BMI and present it as a novel measure, they do not provide a compelling
rationale for why it was examined in this study.
Here are the reasons for my continued skepticism:
--The authors have not adequately addressed my earlier question regarding whether there are
any published articles that previously used ABSI. They mentioned that they addressed this on
page 13 but did not cite any. This raises doubts about the practical applicability and broader
acceptance of ABSI (as there are no other previously published papers that used ABSI).
--While the authors show the supposed superiority of ABSI compared to BMI, weight, height,
etc (figure 3), they do not seem to have fully understood my question regarding the model used
to generate the ROC curves. Their response that they used a “pure ROC curve analysis” does
not clarify the methodology, leading me to question the validity of their statistical approach.
Without a clear explanation of the model used to produce the ROC curves, I find it difficult to
trust their AUC results. Also, the lack of knowledge and transparency on their own methodology
used to create the ROC curves raise serious concerns about reproducibility of their results. Also,
the authors should also report 95% confidence interval for these AUCs.
Please review this paper.
user
Title: Association of “A Body Shape Index” with the risk of developing colorectal cancer in
U.S. patients with metabolic syndrome: Evidence from the NHANES 1999-2018
Version: 2 Date: 13 Oct 2024
Reviewer's report:
I remain unconvinced about the authors' choice to look at ABSI. Although they argue that ABSI
is independent of BMI and present it as a novel measure, they do not provide a compelling
rationale for why it was examined in this study.
Here are the reasons for my continued skepticism:
--The authors have not adequately addressed my earlier question regarding whether there are
any published articles that previously used ABSI. They mentioned that they addressed this on
page 13 but did not cite any. This raises doubts about the practical applicability and broader
acceptance of ABSI (as there are no other previously published papers that used ABSI).
--While the authors show the supposed superiority of ABSI compared to BMI, weight, height,
etc (figure 3), they do not seem to have fully understood my question regarding the model used
to generate the ROC curves. Their response that they used a “pure ROC curve analysis” does
not clarify the methodology, leading me to question the validity of their statistical approach.
Without a clear explanation of the model used to produce the ROC curves, I find it difficult to
trust their AUC results. Also, the lack of knowledge and transparency on their own methodology
used to create the ROC curves raise serious concerns about reproducibility of their results. Also,
the authors should also report 95% confidence interval for these AUCs.
assistant