Title: Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing
endoscopic inflammatory bowel disease severity
Version: 3 Date: 27 Aug 2023
Reviewer:  Cher Shiong Chuah
Reviewer's report:
Can the authors comment on whether they are aware or use faecal calprotectin testing in their
clinical practice (AUC of calprotectin is superior to platelet/albumin ratio in the established
literature - has been in use for over 20 years and it is much more accurate)?
What are the implications of these findings?  I don't think these findings are particularly novel.
We already know that patients with IBD have high platelet counts and low albumin is a general
marker of chronicity. The performance of this ratio is barely better than CRP.
Limitations of this ratio should be clearly discussed - On the basis of an AUC of 0.705 I would
not base any clinical decision-making on it as it is too inaccurate.
Title: Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing
endoscopic inflammatory bowel disease severity
Version: 3 Date: 27 Aug 2023
Reviewer:  Cher Shiong Chuah
Reviewer's report:
Can the authors comment on whether they are aware or use faecal calprotectin testing in their
clinical practice (AUC of calprotectin is superior to platelet/albumin ratio in the established
literature - has been in use for over 20 years and it is much more accurate)?
What are the implications of these findings?  I don't think these findings are particularly novel.
We already know that patients with IBD have high platelet counts and low albumin is a general
marker of chronicity. The performance of this ratio is barely better than CRP.
Limitations of this ratio should be clearly discussed - On the basis of an AUC of 0.705 I would
not base any clinical decision-making on it as it is too inaccurate.
Please review this paper.
user
Title: Platelet/Albumin ratio and plateletcrit levels are potential new biomarkers for assessing
endoscopic inflammatory bowel disease severity
Version: 3 Date: 27 Aug 2023
Reviewer:  Cher Shiong Chuah
Reviewer's report:
Can the authors comment on whether they are aware or use faecal calprotectin testing in their
clinical practice (AUC of calprotectin is superior to platelet/albumin ratio in the established
literature - has been in use for over 20 years and it is much more accurate)?
What are the implications of these findings?  I don't think these findings are particularly novel.
We already know that patients with IBD have high platelet counts and low albumin is a general
marker of chronicity. The performance of this ratio is barely better than CRP.
Limitations of this ratio should be clearly discussed - On the basis of an AUC of 0.705 I would
not base any clinical decision-making on it as it is too inaccurate.
assistant