Title: ERMAP attenuates DSS-induced colitis  in mice by regulating macrophage and T cell
functions
Version: 2 Date: 11 Mar 2025
Reviewer's report:
The revised manuscript has shown significant improvement in quality. However, several issues
still necessitate attention to ensure the clarity and accuracy of the presented data:
1. Please incorporate scatter points into the bar chats. This addition will provide a clearer
representation of the data distribution.
2. Please check the results in Figure 3B. The observed increase in CFSE staining levels within
the DSS+ERMAP groups require to confirm its validity?
3. Please check figure labeling in Fig. 4A. The distinction between the data presented in the
upper and lower sections is not evident, as they appear to convey similar information. Please
elucidate the difference.
4. In Figure 4B, the flow cytometry results illustrated lack sufficient differentiation among the
groups.
5. The rationale behind the selection of the NOD-like receptor for the study, as highlighted in
Figure 5, is not fully represented. The authors are encouraged to provide a more comprehensive
justification for this choice.
6. In Figure 5B, it is crucial to confirm whether control groups were subjected to infection with
a control viral vector.
Title: ERMAP attenuates DSS-induced colitis  in mice by regulating macrophage and T cell
functions
Version: 2 Date: 11 Mar 2025
Reviewer's report:
The revised manuscript has shown significant improvement in quality. However, several issues
still necessitate attention to ensure the clarity and accuracy of the presented data:
1. Please incorporate scatter points into the bar chats. This addition will provide a clearer
representation of the data distribution.
2. Please check the results in Figure 3B. The observed increase in CFSE staining levels within
the DSS+ERMAP groups require to confirm its validity?
3. Please check figure labeling in Fig. 4A. The distinction between the data presented in the
upper and lower sections is not evident, as they appear to convey similar information. Please
elucidate the difference.
4. In Figure 4B, the flow cytometry results illustrated lack sufficient differentiation among the
groups.
5. The rationale behind the selection of the NOD-like receptor for the study, as highlighted in
Figure 5, is not fully represented. The authors are encouraged to provide a more comprehensive
justification for this choice.
6. In Figure 5B, it is crucial to confirm whether control groups were subjected to infection with
a control viral vector.
Please review this paper.
user
Title: ERMAP attenuates DSS-induced colitis  in mice by regulating macrophage and T cell
functions
Version: 2 Date: 11 Mar 2025
Reviewer's report:
The revised manuscript has shown significant improvement in quality. However, several issues
still necessitate attention to ensure the clarity and accuracy of the presented data:
1. Please incorporate scatter points into the bar chats. This addition will provide a clearer
representation of the data distribution.
2. Please check the results in Figure 3B. The observed increase in CFSE staining levels within
the DSS+ERMAP groups require to confirm its validity?
3. Please check figure labeling in Fig. 4A. The distinction between the data presented in the
upper and lower sections is not evident, as they appear to convey similar information. Please
elucidate the difference.
4. In Figure 4B, the flow cytometry results illustrated lack sufficient differentiation among the
groups.
5. The rationale behind the selection of the NOD-like receptor for the study, as highlighted in
Figure 5, is not fully represented. The authors are encouraged to provide a more comprehensive
justification for this choice.
6. In Figure 5B, it is crucial to confirm whether control groups were subjected to infection with
a control viral vector.
assistant