Title: High Correlation of Hepatic Shear Wave Velocity with Esophageal Varices Complication
Rate in Patients with Chronic Liver Diseases
Version: 1 Date: 06 Apr 2023
Reviewer's report:
The authors investigated the correlations of pSWE with hepatic inflammation/fibrosis,
functional hepatic reserve, and related diseases in patients with CLD. They showed that pSWE
was highly correlated with hepatic fibrosis and EV complication. The findings are already
reported in the previous studies. I have several considerable concerns.
Major comments
#1. The numbers of patients studied are too small. The number of total patients studied is only
71. EVs are assessed only in 45 patients.
#2. The pathogenesis of CLD is heterogeneous, which is likely to affect the relationship of pSWE
values to fibrosis or EVs.
#3. Some patients have severe exacerbation with high ALT levels which are likely to affect the
pSWE values.
#4. They should perform the statistical comparison of the AUCROC of pSWE values with those
of the other factors for detecting cirrhosis and EVs.
#5. They should suggest the cut-off values of pSWE values for cirrhosis and EVs.
#6. The authors used parametric methods (mean ± SD and Pearson product-moment correlation
efficient) and nonparametric methods (median, interquartile range and Mann-Whitney U test).
I think that it is inappropriate to use different methods to analyze the same data.
Minor comments
#1. P5, line 7. Some words must be omitted by error.
#2. P9, line 10. There is redundancy of “and”.
#3. P10, lines14-16. Ref. 24 is not Park’s.
Title: High Correlation of Hepatic Shear Wave Velocity with Esophageal Varices Complication
Rate in Patients with Chronic Liver Diseases
Version: 1 Date: 06 Apr 2023
Reviewer's report:
The authors investigated the correlations of pSWE with hepatic inflammation/fibrosis,
functional hepatic reserve, and related diseases in patients with CLD. They showed that pSWE
was highly correlated with hepatic fibrosis and EV complication. The findings are already
reported in the previous studies. I have several considerable concerns.
Major comments
#1. The numbers of patients studied are too small. The number of total patients studied is only
71. EVs are assessed only in 45 patients.
#2. The pathogenesis of CLD is heterogeneous, which is likely to affect the relationship of pSWE
values to fibrosis or EVs.
#3. Some patients have severe exacerbation with high ALT levels which are likely to affect the
pSWE values.
#4. They should perform the statistical comparison of the AUCROC of pSWE values with those
of the other factors for detecting cirrhosis and EVs.
#5. They should suggest the cut-off values of pSWE values for cirrhosis and EVs.
#6. The authors used parametric methods (mean ± SD and Pearson product-moment correlation
efficient) and nonparametric methods (median, interquartile range and Mann-Whitney U test).
I think that it is inappropriate to use different methods to analyze the same data.
Minor comments
#1. P5, line 7. Some words must be omitted by error.
#2. P9, line 10. There is redundancy of “and”.
#3. P10, lines14-16. Ref. 24 is not Park’s.
Please review this paper.
user
Title: High Correlation of Hepatic Shear Wave Velocity with Esophageal Varices Complication
Rate in Patients with Chronic Liver Diseases
Version: 1 Date: 06 Apr 2023
Reviewer's report:
The authors investigated the correlations of pSWE with hepatic inflammation/fibrosis,
functional hepatic reserve, and related diseases in patients with CLD. They showed that pSWE
was highly correlated with hepatic fibrosis and EV complication. The findings are already
reported in the previous studies. I have several considerable concerns.
Major comments
#1. The numbers of patients studied are too small. The number of total patients studied is only
71. EVs are assessed only in 45 patients.
#2. The pathogenesis of CLD is heterogeneous, which is likely to affect the relationship of pSWE
values to fibrosis or EVs.
#3. Some patients have severe exacerbation with high ALT levels which are likely to affect the
pSWE values.
#4. They should perform the statistical comparison of the AUCROC of pSWE values with those
of the other factors for detecting cirrhosis and EVs.
#5. They should suggest the cut-off values of pSWE values for cirrhosis and EVs.
#6. The authors used parametric methods (mean ± SD and Pearson product-moment correlation
efficient) and nonparametric methods (median, interquartile range and Mann-Whitney U test).
I think that it is inappropriate to use different methods to analyze the same data.
Minor comments
#1. P5, line 7. Some words must be omitted by error.
#2. P9, line 10. There is redundancy of “and”.
#3. P10, lines14-16. Ref. 24 is not Park’s.
assistant