Title: Nomogram Predicts Risk of Perineural Invasion Based on Serum Biomarkers for
Pancreatic Cancer
Version: 0 Date: 03 Apr 2023
Reviewer:  Ragesh B. Thandassery
Reviewer's report:
Well conducted study and the results are pertinent. Predicting perineural invasion in pancreatic
adenocarcinoma is extremely important, and a predictive model is very helpful. A proportion of
tumors do not produce  CA 19-9, and the model is not helpful.
As we know, tumor biology and behavior are very variable, and three parameters identified in
this study (preoperative blood glucose, preoperative total bilirubin, and preoperative CA19-9)
should be validated in larger prospective multicenter cohorts.
In the discussion, please include more related studies for comparison of results of your study.
Title: Nomogram Predicts Risk of Perineural Invasion Based on Serum Biomarkers for
Pancreatic Cancer
Version: 0 Date: 03 Apr 2023
Reviewer:  Ragesh B. Thandassery
Reviewer's report:
Well conducted study and the results are pertinent. Predicting perineural invasion in pancreatic
adenocarcinoma is extremely important, and a predictive model is very helpful. A proportion of
tumors do not produce  CA 19-9, and the model is not helpful.
As we know, tumor biology and behavior are very variable, and three parameters identified in
this study (preoperative blood glucose, preoperative total bilirubin, and preoperative CA19-9)
should be validated in larger prospective multicenter cohorts.
In the discussion, please include more related studies for comparison of results of your study.
Please review this paper.
user
Title: Nomogram Predicts Risk of Perineural Invasion Based on Serum Biomarkers for
Pancreatic Cancer
Version: 0 Date: 03 Apr 2023
Reviewer:  Ragesh B. Thandassery
Reviewer's report:
Well conducted study and the results are pertinent. Predicting perineural invasion in pancreatic
adenocarcinoma is extremely important, and a predictive model is very helpful. A proportion of
tumors do not produce  CA 19-9, and the model is not helpful.
As we know, tumor biology and behavior are very variable, and three parameters identified in
this study (preoperative blood glucose, preoperative total bilirubin, and preoperative CA19-9)
should be validated in larger prospective multicenter cohorts.
In the discussion, please include more related studies for comparison of results of your study.
assistant