Title: Systematic Review and Meta-Analysis: No Evidence That Low-dose Non-Steroidal Anti-
Inflammatory Drugs (NSAIDs) Reduce the Risk of Pancreatitis After Endoscopic Retrograde
Cholangiopancreatography (ERCP)
Version: 3 Date: 09 Jan 2025
Reviewer:  Amira A A Othman
Reviewer's report:
The authors have made a significant effort and responded well to the reviewers' comments,
demonstrating a clear commitment to improving the quality of their manuscript. However, a few
additional adjustments are still needed to achieve the best possible version of the manuscript.
1. Simplify the abstract and make it more structured, emphasizing key findings and clinical
relevance.
2. Avoid repetition in the introduction about the need for prevention strategies and emphasize
NSAID efficacy findings.
3. Specify the variables used in propensity score matching (e.g., age, sex, comorbidities), and
provide detailed exclusion criteria in the methodology section.
4. Statistical findings need better explanation (e.g., odds ratios, significance of low heterogeneity
(I² = 0%), sensitivity analysis ).
5. Provide a critical comparison of your results with other studies in the discussion section
especially lack of significant findings (e.g., low NSAID doses).
6. Table 1 is terrible, please reconstruct it.
Title: Systematic Review and Meta-Analysis: No Evidence That Low-dose Non-Steroidal Anti-
Inflammatory Drugs (NSAIDs) Reduce the Risk of Pancreatitis After Endoscopic Retrograde
Cholangiopancreatography (ERCP)
Version: 3 Date: 09 Jan 2025
Reviewer:  Amira A A Othman
Reviewer's report:
The authors have made a significant effort and responded well to the reviewers' comments,
demonstrating a clear commitment to improving the quality of their manuscript. However, a few
additional adjustments are still needed to achieve the best possible version of the manuscript.
1. Simplify the abstract and make it more structured, emphasizing key findings and clinical
relevance.
2. Avoid repetition in the introduction about the need for prevention strategies and emphasize
NSAID efficacy findings.
3. Specify the variables used in propensity score matching (e.g., age, sex, comorbidities), and
provide detailed exclusion criteria in the methodology section.
4. Statistical findings need better explanation (e.g., odds ratios, significance of low heterogeneity
(I² = 0%), sensitivity analysis ).
5. Provide a critical comparison of your results with other studies in the discussion section
especially lack of significant findings (e.g., low NSAID doses).
6. Table 1 is terrible, please reconstruct it.
Please review this paper.
user
Title: Systematic Review and Meta-Analysis: No Evidence That Low-dose Non-Steroidal Anti-
Inflammatory Drugs (NSAIDs) Reduce the Risk of Pancreatitis After Endoscopic Retrograde
Cholangiopancreatography (ERCP)
Version: 3 Date: 09 Jan 2025
Reviewer:  Amira A A Othman
Reviewer's report:
The authors have made a significant effort and responded well to the reviewers' comments,
demonstrating a clear commitment to improving the quality of their manuscript. However, a few
additional adjustments are still needed to achieve the best possible version of the manuscript.
1. Simplify the abstract and make it more structured, emphasizing key findings and clinical
relevance.
2. Avoid repetition in the introduction about the need for prevention strategies and emphasize
NSAID efficacy findings.
3. Specify the variables used in propensity score matching (e.g., age, sex, comorbidities), and
provide detailed exclusion criteria in the methodology section.
4. Statistical findings need better explanation (e.g., odds ratios, significance of low heterogeneity
(I² = 0%), sensitivity analysis ).
5. Provide a critical comparison of your results with other studies in the discussion section
especially lack of significant findings (e.g., low NSAID doses).
6. Table 1 is terrible, please reconstruct it.
assistant