Reviewer's report
Title:Prevalence of Genetic Polymorphisms in the Promoter Region of the
Alpha-1 Antitrypsin (SERPINA1) Gene in Chronic Liver Disease: a Case Control
Study
Version: 2Date:20 November 2009
Reviewer: Ahmad Settin
Reviewer's report:
This study concerning the prevalence of c.-1973T>C, Z allele and S allele in a
cohort of patients with liver disease of various aetiologies compared with healthy
controls sounds an interesting study. Generally it is well written, well presented
and well organized with statistically validated data. The main weakness,
however, is the relatively non homogeneous sample of cases with liver disease, if
authors would have focused on one disorder e.g HCV and enriched their sample
of same affected cases, I think will be far more better, In spite of this we still can
speculate that at minimum these genetic polymorphisms did not appear to be a
risk factor for chronicity of liver affection by these disorder.
These include more informative tables about the distribution of all genotypes and
alleles pertaining to A1AT gene significance of difference related to Allele
frequencies in both studied groups and also about
the analysis of frequencies related to the haplotypes analysis of the 3 alleles
together e.g C/S/Z, C/S/M, C/Z/M, T/S/Z, T/S/M, T/Z/M etc. I think figures can be
omitted as well, My final decision is to accept but after minor revision.
Reviewer's report
Title:Prevalence of Genetic Polymorphisms in the Promoter Region of the
Alpha-1 Antitrypsin (SERPINA1) Gene in Chronic Liver Disease: a Case Control
Study
Version: 2Date:20 November 2009
Reviewer: Ahmad Settin
Reviewer's report:
This study concerning the prevalence of c.-1973T>C, Z allele and S allele in a
cohort of patients with liver disease of various aetiologies compared with healthy
controls sounds an interesting study. Generally it is well written, well presented
and well organized with statistically validated data. The main weakness,
however, is the relatively non homogeneous sample of cases with liver disease, if
authors would have focused on one disorder e.g HCV and enriched their sample
of same affected cases, I think will be far more better, In spite of this we still can
speculate that at minimum these genetic polymorphisms did not appear to be a
risk factor for chronicity of liver affection by these disorder.
These include more informative tables about the distribution of all genotypes and
alleles pertaining to A1AT gene significance of difference related to Allele
frequencies in both studied groups and also about
the analysis of frequencies related to the haplotypes analysis of the 3 alleles
together e.g C/S/Z, C/S/M, C/Z/M, T/S/Z, T/S/M, T/Z/M etc. I think figures can be
omitted as well, My final decision is to accept but after minor revision.
Please review this paper.
user
Reviewer's report
Title:Prevalence of Genetic Polymorphisms in the Promoter Region of the
Alpha-1 Antitrypsin (SERPINA1) Gene in Chronic Liver Disease: a Case Control
Study
Version: 2Date:20 November 2009
Reviewer: Ahmad Settin
Reviewer's report:
This study concerning the prevalence of c.-1973T>C, Z allele and S allele in a
cohort of patients with liver disease of various aetiologies compared with healthy
controls sounds an interesting study. Generally it is well written, well presented
and well organized with statistically validated data. The main weakness,
however, is the relatively non homogeneous sample of cases with liver disease, if
authors would have focused on one disorder e.g HCV and enriched their sample
of same affected cases, I think will be far more better, In spite of this we still can
speculate that at minimum these genetic polymorphisms did not appear to be a
risk factor for chronicity of liver affection by these disorder.
These include more informative tables about the distribution of all genotypes and
alleles pertaining to A1AT gene significance of difference related to Allele
frequencies in both studied groups and also about
the analysis of frequencies related to the haplotypes analysis of the 3 alleles
together e.g C/S/Z, C/S/M, C/Z/M, T/S/Z, T/S/M, T/Z/M etc. I think figures can be
omitted as well, My final decision is to accept but after minor revision.
assistant