Title: Absent or impaired rectoanal inhibitory reflex as a diagnostic factor for high-grade (grade
III–V) rectal prolapse: a retrospective study
Version: 1 Date: 03 Feb 2021
Reviewer's report:
Methods:
Maybe the name ‘abnormal RAIR’ is not the correct name since you do not see anything special
on the RAIR but only do not see a RAIR, or the RAIR does reduce the anal resting pressure less
than 25%. Alternative: ‘No or less effective RAIR’
Has been checked if the patients with an abnormal RAIR had ganglioncels? It happens that at
adult age Hirschsprung is being diagnosed for the first time.
The asymmetry of the anal sphincter measurement is extremely sensitive for accidental position
mistakes when measured. How was checked that this measured correctly?
Statistical analyses:
How was checked that data was normally distributed?
Discussion:
If also the low grade group did have an abnormal RAIR, how can the abnormal RAIR than help
to diagnose the high grade group?
There are many other reasons to have a low maximum squeezing pressure, how can this
parameter than be a predictor of high grade rectal prolapse?
The shorting MRP and MSP were used without first mentioning them. Be careful that everyone
can follow your story.
Reference:
Reference 40 is not correct mentioned
Title: Absent or impaired rectoanal inhibitory reflex as a diagnostic factor for high-grade (grade
III–V) rectal prolapse: a retrospective study
Version: 1 Date: 03 Feb 2021
Reviewer's report:
Methods:
Maybe the name ‘abnormal RAIR’ is not the correct name since you do not see anything special
on the RAIR but only do not see a RAIR, or the RAIR does reduce the anal resting pressure less
than 25%. Alternative: ‘No or less effective RAIR’
Has been checked if the patients with an abnormal RAIR had ganglioncels? It happens that at
adult age Hirschsprung is being diagnosed for the first time.
The asymmetry of the anal sphincter measurement is extremely sensitive for accidental position
mistakes when measured. How was checked that this measured correctly?
Statistical analyses:
How was checked that data was normally distributed?
Discussion:
If also the low grade group did have an abnormal RAIR, how can the abnormal RAIR than help
to diagnose the high grade group?
There are many other reasons to have a low maximum squeezing pressure, how can this
parameter than be a predictor of high grade rectal prolapse?
The shorting MRP and MSP were used without first mentioning them. Be careful that everyone
can follow your story.
Reference:
Reference 40 is not correct mentioned
Please review this paper.
user
Title: Absent or impaired rectoanal inhibitory reflex as a diagnostic factor for high-grade (grade
III–V) rectal prolapse: a retrospective study
Version: 1 Date: 03 Feb 2021
Reviewer's report:
Methods:
Maybe the name ‘abnormal RAIR’ is not the correct name since you do not see anything special
on the RAIR but only do not see a RAIR, or the RAIR does reduce the anal resting pressure less
than 25%. Alternative: ‘No or less effective RAIR’
Has been checked if the patients with an abnormal RAIR had ganglioncels? It happens that at
adult age Hirschsprung is being diagnosed for the first time.
The asymmetry of the anal sphincter measurement is extremely sensitive for accidental position
mistakes when measured. How was checked that this measured correctly?
Statistical analyses:
How was checked that data was normally distributed?
Discussion:
If also the low grade group did have an abnormal RAIR, how can the abnormal RAIR than help
to diagnose the high grade group?
There are many other reasons to have a low maximum squeezing pressure, how can this
parameter than be a predictor of high grade rectal prolapse?
The shorting MRP and MSP were used without first mentioning them. Be careful that everyone
can follow your story.
Reference:
Reference 40 is not correct mentioned
assistant