Title: Value of contrast-enhanced ultrasound in diagnosis and differential diagnosis of polypoid
lesions of gallbladder# 1 cm
Version: 4 Date: 02 May 2022
Reviewer's report:
This work treated the interesting topic of the evaluation of gallbladder lesions > 10 mm with
contrast-enhanced ultrasound.
It was well-conducted and it provided further evidence about the differential diagnosis of
gallbladder lesions in order to reduce the rate of unnecessary cholecystectomies.
Some English polishing is needed.
INTRODUCTION
- In the “Introduction” the first time you use words with the abbreviations, you have to write
in the entire form and not with abbreviations (e.g. “ Polypoid lesions of the gallbladder (PLGs)
refer to …”/ “…protrude into gallbladder (GB) lumen…”,…)
- First line: “ It’s a relatively common disease/They are a relatively common disease”. PLGs
are plural.
- Add literature percentage about malignant and benign nature of PLGs > 10 mm
- Add some data about the diagnostic yield of US, CEUS, CT and MRI for the differential
diagnosis of PLGs > 10 mm
- I think that the study aims should be expressed better. They may be summarized as the
evaluation of the diagnostic yield of CEUS for the differential diagnosis of PLGs # 1.0 cm and
the factors affecting it.
MATERIALS AND METHODS
- Age should be expressed as a median with range or as a mean with a standard deviation
RESULTS
- “Among the malignant cases, one case of adenomyomatosis and six cases of adenoma that had
developed into cancer, 22 cases were GB carcinoma (19 cases of adenocarcinoma, and three
cases of adenosquamous carcinoma).” Some English polishing is needed.
DISCUSSION
- Report the rate of unnecessary cholecystectomies (e.g. cholecystectomy for benign lesions,…).
- Write a consideration about savings related to the reduction of cholecystectomies after CEUS
evaluation of GBLs > 10 mm.
- Report the limits of your study
TABLE 1/TABLE 2/TABLE 3/TABLE 4
- I think that you should divide benign lesions from malignant lesions. You can underline data
about malignant and benign lesions in general and then, you can create, subgroups of malignant
and benign lesions (adenoma, chronic cholecystitis, adenomyomatosis,…).
- Please write the measure unit in the first line of the table.
- The statistically or no significance should be added as a final column in all tables (“p” column),
instead of being described in the table description
Title: Value of contrast-enhanced ultrasound in diagnosis and differential diagnosis of polypoid
lesions of gallbladder# 1 cm
Version: 4 Date: 02 May 2022
Reviewer's report:
This work treated the interesting topic of the evaluation of gallbladder lesions > 10 mm with
contrast-enhanced ultrasound.
It was well-conducted and it provided further evidence about the differential diagnosis of
gallbladder lesions in order to reduce the rate of unnecessary cholecystectomies.
Some English polishing is needed.
INTRODUCTION
- In the “Introduction” the first time you use words with the abbreviations, you have to write
in the entire form and not with abbreviations (e.g. “ Polypoid lesions of the gallbladder (PLGs)
refer to …”/ “…protrude into gallbladder (GB) lumen…”,…)
- First line: “ It’s a relatively common disease/They are a relatively common disease”. PLGs
are plural.
- Add literature percentage about malignant and benign nature of PLGs > 10 mm
- Add some data about the diagnostic yield of US, CEUS, CT and MRI for the differential
diagnosis of PLGs > 10 mm
- I think that the study aims should be expressed better. They may be summarized as the
evaluation of the diagnostic yield of CEUS for the differential diagnosis of PLGs # 1.0 cm and
the factors affecting it.
MATERIALS AND METHODS
- Age should be expressed as a median with range or as a mean with a standard deviation
RESULTS
- “Among the malignant cases, one case of adenomyomatosis and six cases of adenoma that had
developed into cancer, 22 cases were GB carcinoma (19 cases of adenocarcinoma, and three
cases of adenosquamous carcinoma).” Some English polishing is needed.
DISCUSSION
- Report the rate of unnecessary cholecystectomies (e.g. cholecystectomy for benign lesions,…).
- Write a consideration about savings related to the reduction of cholecystectomies after CEUS
evaluation of GBLs > 10 mm.
- Report the limits of your study
TABLE 1/TABLE 2/TABLE 3/TABLE 4
- I think that you should divide benign lesions from malignant lesions. You can underline data
about malignant and benign lesions in general and then, you can create, subgroups of malignant
and benign lesions (adenoma, chronic cholecystitis, adenomyomatosis,…).
- Please write the measure unit in the first line of the table.
- The statistically or no significance should be added as a final column in all tables (“p” column),
instead of being described in the table description
Please review this paper.
user
Title: Value of contrast-enhanced ultrasound in diagnosis and differential diagnosis of polypoid
lesions of gallbladder# 1 cm
Version: 4 Date: 02 May 2022
Reviewer's report:
This work treated the interesting topic of the evaluation of gallbladder lesions > 10 mm with
contrast-enhanced ultrasound.
It was well-conducted and it provided further evidence about the differential diagnosis of
gallbladder lesions in order to reduce the rate of unnecessary cholecystectomies.
Some English polishing is needed.
INTRODUCTION
- In the “Introduction” the first time you use words with the abbreviations, you have to write
in the entire form and not with abbreviations (e.g. “ Polypoid lesions of the gallbladder (PLGs)
refer to …”/ “…protrude into gallbladder (GB) lumen…”,…)
- First line: “ It’s a relatively common disease/They are a relatively common disease”. PLGs
are plural.
- Add literature percentage about malignant and benign nature of PLGs > 10 mm
- Add some data about the diagnostic yield of US, CEUS, CT and MRI for the differential
diagnosis of PLGs > 10 mm
- I think that the study aims should be expressed better. They may be summarized as the
evaluation of the diagnostic yield of CEUS for the differential diagnosis of PLGs # 1.0 cm and
the factors affecting it.
MATERIALS AND METHODS
- Age should be expressed as a median with range or as a mean with a standard deviation
RESULTS
- “Among the malignant cases, one case of adenomyomatosis and six cases of adenoma that had
developed into cancer, 22 cases were GB carcinoma (19 cases of adenocarcinoma, and three
cases of adenosquamous carcinoma).” Some English polishing is needed.
DISCUSSION
- Report the rate of unnecessary cholecystectomies (e.g. cholecystectomy for benign lesions,…).
- Write a consideration about savings related to the reduction of cholecystectomies after CEUS
evaluation of GBLs > 10 mm.
- Report the limits of your study
TABLE 1/TABLE 2/TABLE 3/TABLE 4
- I think that you should divide benign lesions from malignant lesions. You can underline data
about malignant and benign lesions in general and then, you can create, subgroups of malignant
and benign lesions (adenoma, chronic cholecystitis, adenomyomatosis,…).
- Please write the measure unit in the first line of the table.
- The statistically or no significance should be added as a final column in all tables (“p” column),
instead of being described in the table description
assistant