Title: A radiomics model fusing clinical features to predict microsatellite status preoperatively
in colorectal cancer liver metastasis
Version: 3 Date: 01 Feb 2023
Reviewer's report:
Dear Author,
in the era of precision medicine the theme treated appears really interesting. Matherial and
Methods are explained clearly and the model building appears reproducible.
As MSI mutation rapresent a small part of rectal cancer, the sample of mutation patients is small.
Please give the readers suggestion to make the AI model reliable and compare the nomogram
to formal methods applied to colorectal liver metastases.
In the discussion, please explain also the impact of the early diagnosis of MSI in the choice
of treatment strategy  especially in synchronous patients. (Rocca, A., Cipriani, F., Belli, G.
et al. The Italian Consensus on minimally invasive simultaneous resections for synchronous
liver metastasis and primary colorectal cancer: A Delphi methodology. Updates Surg 73,
1247–1265 (2021). https://doi.org/10.1007/s13304-021-01100-9;) ; or the impact of the most
appropriate timing of surgical treatment considering the advantages of minimally invasive
surgery (Ceccarelli G, Andolfi E, Fontani A, Calise F, Rocca A, Giuliani A. Robot-assisted liver
surgery in a general surgery unit with a "Referral Centre Hub&Spoke Learning Program". Early
outcomes after our first 70 consecutive patients. Minerva Chir. 2018 Oct;73(5):460-468. doi:
10.23736/S0026-4733.18.07651-4. Epub 2018 May 24. PMID: 29795060.)
Figure 3 is described as "The (A) shows the ROC curves of three models in original data
validation sets, and the (B) shows the ROC curves of three models in original data validation
sets”. Which is the difference between A and B?
In Table 2 you could also explain the abbreviation.
You can also consider to extend also the text with the results shown in figures and table.
Title: A radiomics model fusing clinical features to predict microsatellite status preoperatively
in colorectal cancer liver metastasis
Version: 3 Date: 01 Feb 2023
Reviewer's report:
Dear Author,
in the era of precision medicine the theme treated appears really interesting. Matherial and
Methods are explained clearly and the model building appears reproducible.
As MSI mutation rapresent a small part of rectal cancer, the sample of mutation patients is small.
Please give the readers suggestion to make the AI model reliable and compare the nomogram
to formal methods applied to colorectal liver metastases.
In the discussion, please explain also the impact of the early diagnosis of MSI in the choice
of treatment strategy  especially in synchronous patients. (Rocca, A., Cipriani, F., Belli, G.
et al. The Italian Consensus on minimally invasive simultaneous resections for synchronous
liver metastasis and primary colorectal cancer: A Delphi methodology. Updates Surg 73,
1247–1265 (2021). https://doi.org/10.1007/s13304-021-01100-9;) ; or the impact of the most
appropriate timing of surgical treatment considering the advantages of minimally invasive
surgery (Ceccarelli G, Andolfi E, Fontani A, Calise F, Rocca A, Giuliani A. Robot-assisted liver
surgery in a general surgery unit with a "Referral Centre Hub&Spoke Learning Program". Early
outcomes after our first 70 consecutive patients. Minerva Chir. 2018 Oct;73(5):460-468. doi:
10.23736/S0026-4733.18.07651-4. Epub 2018 May 24. PMID: 29795060.)
Figure 3 is described as "The (A) shows the ROC curves of three models in original data
validation sets, and the (B) shows the ROC curves of three models in original data validation
sets”. Which is the difference between A and B?
In Table 2 you could also explain the abbreviation.
You can also consider to extend also the text with the results shown in figures and table.
Please review this paper.
user
Title: A radiomics model fusing clinical features to predict microsatellite status preoperatively
in colorectal cancer liver metastasis
Version: 3 Date: 01 Feb 2023
Reviewer's report:
Dear Author,
in the era of precision medicine the theme treated appears really interesting. Matherial and
Methods are explained clearly and the model building appears reproducible.
As MSI mutation rapresent a small part of rectal cancer, the sample of mutation patients is small.
Please give the readers suggestion to make the AI model reliable and compare the nomogram
to formal methods applied to colorectal liver metastases.
In the discussion, please explain also the impact of the early diagnosis of MSI in the choice
of treatment strategy  especially in synchronous patients. (Rocca, A., Cipriani, F., Belli, G.
et al. The Italian Consensus on minimally invasive simultaneous resections for synchronous
liver metastasis and primary colorectal cancer: A Delphi methodology. Updates Surg 73,
1247–1265 (2021). https://doi.org/10.1007/s13304-021-01100-9;) ; or the impact of the most
appropriate timing of surgical treatment considering the advantages of minimally invasive
surgery (Ceccarelli G, Andolfi E, Fontani A, Calise F, Rocca A, Giuliani A. Robot-assisted liver
surgery in a general surgery unit with a "Referral Centre Hub&Spoke Learning Program". Early
outcomes after our first 70 consecutive patients. Minerva Chir. 2018 Oct;73(5):460-468. doi:
10.23736/S0026-4733.18.07651-4. Epub 2018 May 24. PMID: 29795060.)
Figure 3 is described as "The (A) shows the ROC curves of three models in original data
validation sets, and the (B) shows the ROC curves of three models in original data validation
sets”. Which is the difference between A and B?
In Table 2 you could also explain the abbreviation.
You can also consider to extend also the text with the results shown in figures and table.
assistant