Title: Symptoms, burden, and unmet needs of patients living with exocrine pancreatic
insufficiency: a narrative review of the patient experience
Version: 0 Date: 22 Jul 2023
Reviewer's report:
This comprehensive review of the literature, on the experience of patient of living with exocrine
pancreatic insufficiency, revealed that there are aspects we still do not know about the patient's
experience with EPI, such as emotional functioning and disease burden. It also shows that we
lack long-term studies on the effects of PERT, on the quality of life and on comorbidities. It is
clear that a large part of the symptoms are taken to one's own disease, and not only to EPI.
As expected, HRQoL is adversely affected by EPI and its symptoms and impacts in all
HRQoL domains. The literature identified indicates that individuals with EPI suffer from
many comorbidities and that treatment with PERT led to a decrease in abdominal pain, aided
significantly in digestion and fat absorption. There was also a lack of studies on the long-term
effects of PERT and studies to explain the disease and its progression.
The manuscript is a highly accomplished literature review, and may help to guide future studies
of the effects of the PEI, taking into account the Patient Reported Outcomes Measures,(PROM)
and Patient Reported Experience, Press) to help build value in health.
I consider the manuscript to be appropriate for publication in BMC Gastroenterology as it is
written.
Title: Symptoms, burden, and unmet needs of patients living with exocrine pancreatic
insufficiency: a narrative review of the patient experience
Version: 0 Date: 22 Jul 2023
Reviewer's report:
This comprehensive review of the literature, on the experience of patient of living with exocrine
pancreatic insufficiency, revealed that there are aspects we still do not know about the patient's
experience with EPI, such as emotional functioning and disease burden. It also shows that we
lack long-term studies on the effects of PERT, on the quality of life and on comorbidities. It is
clear that a large part of the symptoms are taken to one's own disease, and not only to EPI.
As expected, HRQoL is adversely affected by EPI and its symptoms and impacts in all
HRQoL domains. The literature identified indicates that individuals with EPI suffer from
many comorbidities and that treatment with PERT led to a decrease in abdominal pain, aided
significantly in digestion and fat absorption. There was also a lack of studies on the long-term
effects of PERT and studies to explain the disease and its progression.
The manuscript is a highly accomplished literature review, and may help to guide future studies
of the effects of the PEI, taking into account the Patient Reported Outcomes Measures,(PROM)
and Patient Reported Experience, Press) to help build value in health.
I consider the manuscript to be appropriate for publication in BMC Gastroenterology as it is
written.
Please review this paper.
user
Title: Symptoms, burden, and unmet needs of patients living with exocrine pancreatic
insufficiency: a narrative review of the patient experience
Version: 0 Date: 22 Jul 2023
Reviewer's report:
This comprehensive review of the literature, on the experience of patient of living with exocrine
pancreatic insufficiency, revealed that there are aspects we still do not know about the patient's
experience with EPI, such as emotional functioning and disease burden. It also shows that we
lack long-term studies on the effects of PERT, on the quality of life and on comorbidities. It is
clear that a large part of the symptoms are taken to one's own disease, and not only to EPI.
As expected, HRQoL is adversely affected by EPI and its symptoms and impacts in all
HRQoL domains. The literature identified indicates that individuals with EPI suffer from
many comorbidities and that treatment with PERT led to a decrease in abdominal pain, aided
significantly in digestion and fat absorption. There was also a lack of studies on the long-term
effects of PERT and studies to explain the disease and its progression.
The manuscript is a highly accomplished literature review, and may help to guide future studies
of the effects of the PEI, taking into account the Patient Reported Outcomes Measures,(PROM)
and Patient Reported Experience, Press) to help build value in health.
I consider the manuscript to be appropriate for publication in BMC Gastroenterology as it is
written.
assistant