Reviewer's report
Title:The Prevalence of Gastro-Esophageal Reflux Disease and Esophageal
Dysmotility in Chinese Patients with Idiopathic Pulmonary Fibrosis
Version:2Date:1 October 2014
Reviewer: fernando Herbella
Reviewer's report:
Gao et al. present a prospective case series of esophageal function tests in 69
patients with IPF.
There are other studies showing the high prevalence of GERD in these patients.
The authors could fill some blanks in the literature by discussing their findings
from the point of view of an esophageal physiologist.
Major Compulsory Revisions
1) According to the findings, the esophagogastric barrier is normal in patients
with GERD +. In consequence, Is GERD secondary to an increased
transdiphragmatic pressure gradient and not the primary cause for IPF? Please
discuss.
2) What was the contribution of MII-pH in the study? How many patients had
abnormal non-acid reflux and normal acid reflux?
Minor Essential Revisions
1) Figures are not contributory.
2) Table 4 is not clear
3) et al., not et al
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No conflict of interest.
Reviewer's report
Title:The Prevalence of Gastro-Esophageal Reflux Disease and Esophageal
Dysmotility in Chinese Patients with Idiopathic Pulmonary Fibrosis
Version:2Date:1 October 2014
Reviewer: fernando Herbella
Reviewer's report:
Gao et al. present a prospective case series of esophageal function tests in 69
patients with IPF.
There are other studies showing the high prevalence of GERD in these patients.
The authors could fill some blanks in the literature by discussing their findings
from the point of view of an esophageal physiologist.
Major Compulsory Revisions
1) According to the findings, the esophagogastric barrier is normal in patients
with GERD +. In consequence, Is GERD secondary to an increased
transdiphragmatic pressure gradient and not the primary cause for IPF? Please
discuss.
2) What was the contribution of MII-pH in the study? How many patients had
abnormal non-acid reflux and normal acid reflux?
Minor Essential Revisions
1) Figures are not contributory.
2) Table 4 is not clear
3) et al., not et al
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No conflict of interest.
Please review this paper.
user
Reviewer's report
Title:The Prevalence of Gastro-Esophageal Reflux Disease and Esophageal
Dysmotility in Chinese Patients with Idiopathic Pulmonary Fibrosis
Version:2Date:1 October 2014
Reviewer: fernando Herbella
Reviewer's report:
Gao et al. present a prospective case series of esophageal function tests in 69
patients with IPF.
There are other studies showing the high prevalence of GERD in these patients.
The authors could fill some blanks in the literature by discussing their findings
from the point of view of an esophageal physiologist.
Major Compulsory Revisions
1) According to the findings, the esophagogastric barrier is normal in patients
with GERD +. In consequence, Is GERD secondary to an increased
transdiphragmatic pressure gradient and not the primary cause for IPF? Please
discuss.
2) What was the contribution of MII-pH in the study? How many patients had
abnormal non-acid reflux and normal acid reflux?
Minor Essential Revisions
1) Figures are not contributory.
2) Table 4 is not clear
3) et al., not et al
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No conflict of interest.
assistant