Title: Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive
autoimmune hepatitis
Version: 0 Date: 21 Nov 2021
Reviewer's report:
I read with interest "Serum ferritin level is associated with advanced liver fibrosis in treatment-
naive autoimmune hepatitis:; the article is interesting; However; there are major concerns:
- Methods: Sample size calculation and power of the study are important to validate the findings
of the study; also; being a retrospective study raise the possibility of bias.
- Results: not well presented; especially table (1); I think to present fibrosis stages as S1, S2...etc
will be misleading to the readers as results of liver biopsy if related to fibrosis will be interpreted
as F0, F1, F2...etc; if related to activity wil be interpreted as  A1,...etc; S1, S2 this only refers
to steatosis evaluation by fibroscan.
-Discussion: You should clarify more in the discussion the impact of these findings on our
current practice.
Title: Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive
autoimmune hepatitis
Version: 0 Date: 21 Nov 2021
Reviewer's report:
I read with interest "Serum ferritin level is associated with advanced liver fibrosis in treatment-
naive autoimmune hepatitis:; the article is interesting; However; there are major concerns:
- Methods: Sample size calculation and power of the study are important to validate the findings
of the study; also; being a retrospective study raise the possibility of bias.
- Results: not well presented; especially table (1); I think to present fibrosis stages as S1, S2...etc
will be misleading to the readers as results of liver biopsy if related to fibrosis will be interpreted
as F0, F1, F2...etc; if related to activity wil be interpreted as  A1,...etc; S1, S2 this only refers
to steatosis evaluation by fibroscan.
-Discussion: You should clarify more in the discussion the impact of these findings on our
current practice.
Please review this paper.
user
Title: Serum ferritin levels are associated with advanced liver fibrosis in treatment-naive
autoimmune hepatitis
Version: 0 Date: 21 Nov 2021
Reviewer's report:
I read with interest "Serum ferritin level is associated with advanced liver fibrosis in treatment-
naive autoimmune hepatitis:; the article is interesting; However; there are major concerns:
- Methods: Sample size calculation and power of the study are important to validate the findings
of the study; also; being a retrospective study raise the possibility of bias.
- Results: not well presented; especially table (1); I think to present fibrosis stages as S1, S2...etc
will be misleading to the readers as results of liver biopsy if related to fibrosis will be interpreted
as F0, F1, F2...etc; if related to activity wil be interpreted as  A1,...etc; S1, S2 this only refers
to steatosis evaluation by fibroscan.
-Discussion: You should clarify more in the discussion the impact of these findings on our
current practice.
assistant