Title: Efficacy and safety comparison of neoadjuvant chemotherapy followed by surgery and
upfront surgery for treating intrahepatic cholangiocarcinoma: a systematic review and meta-
analysis
Version: 1 Date: 29 Jan 2023
Reviewer's report:
Dear editor
Thank you for your invitation!
The author focus on the prognostic impact of neoadjuvant chemotherapy followed by surgery in
patients with ICC, the found that neoadjuvant chemotherapy followed by surgery could prolong
the 5-year OS, and concluded that the benefit may be more significant in locally advanced ICC.
There were some queries:
Firstly, since the lymph metastases is a important factor for the prognosis of ICC, the author
should be list in the table 1 the positive rate of lymph node, the percent of lymph node dissection.
Secondly, the conclusion demonstrated that the neoadjuvant chemotherapy is suitable for
patients with local advanced, while the result was not mentioned, more data was need to prove
the conclusion.
Thirdly, due to the importance of baseline, the basic characteristic of patients with ICC should
be more clear.
Since the issue was discussed for many years, and the included studies were small, more studies
were need to robust the conclusion.
The author should run over the instrument for author in the website, the format of the manuscript
should be edited again. The footnote should be added in tables and figures.
The part of introduction should be simplified.
Yours,
Nanping Lin
Title: Efficacy and safety comparison of neoadjuvant chemotherapy followed by surgery and
upfront surgery for treating intrahepatic cholangiocarcinoma: a systematic review and meta-
analysis
Version: 1 Date: 29 Jan 2023
Reviewer's report:
Dear editor
Thank you for your invitation!
The author focus on the prognostic impact of neoadjuvant chemotherapy followed by surgery in
patients with ICC, the found that neoadjuvant chemotherapy followed by surgery could prolong
the 5-year OS, and concluded that the benefit may be more significant in locally advanced ICC.
There were some queries:
Firstly, since the lymph metastases is a important factor for the prognosis of ICC, the author
should be list in the table 1 the positive rate of lymph node, the percent of lymph node dissection.
Secondly, the conclusion demonstrated that the neoadjuvant chemotherapy is suitable for
patients with local advanced, while the result was not mentioned, more data was need to prove
the conclusion.
Thirdly, due to the importance of baseline, the basic characteristic of patients with ICC should
be more clear.
Since the issue was discussed for many years, and the included studies were small, more studies
were need to robust the conclusion.
The author should run over the instrument for author in the website, the format of the manuscript
should be edited again. The footnote should be added in tables and figures.
The part of introduction should be simplified.
Yours,
Nanping Lin
Please review this paper.
user
Title: Efficacy and safety comparison of neoadjuvant chemotherapy followed by surgery and
upfront surgery for treating intrahepatic cholangiocarcinoma: a systematic review and meta-
analysis
Version: 1 Date: 29 Jan 2023
Reviewer's report:
Dear editor
Thank you for your invitation!
The author focus on the prognostic impact of neoadjuvant chemotherapy followed by surgery in
patients with ICC, the found that neoadjuvant chemotherapy followed by surgery could prolong
the 5-year OS, and concluded that the benefit may be more significant in locally advanced ICC.
There were some queries:
Firstly, since the lymph metastases is a important factor for the prognosis of ICC, the author
should be list in the table 1 the positive rate of lymph node, the percent of lymph node dissection.
Secondly, the conclusion demonstrated that the neoadjuvant chemotherapy is suitable for
patients with local advanced, while the result was not mentioned, more data was need to prove
the conclusion.
Thirdly, due to the importance of baseline, the basic characteristic of patients with ICC should
be more clear.
Since the issue was discussed for many years, and the included studies were small, more studies
were need to robust the conclusion.
The author should run over the instrument for author in the website, the format of the manuscript
should be edited again. The footnote should be added in tables and figures.
The part of introduction should be simplified.
Yours,
Nanping Lin
assistant