Reviewer's report 
 Gastroparesis secondary to a demyelinating disease: A Case Series Title: 
 1  10 November 2006 Version: Date: 
 Mauro Bortolotti Reviewer: 
Reviewer's report: 
General 
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Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
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Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
- How were the characteristics of the vomiting? Was it neurological? 
- Did the patients have signs of endocranic hypertension at the time of the vomiting start? - No details on the gastric emptying test were given. Was it done with a 
scintigraphic method? The values of the GE parameters before and after 
treatment should be given. 
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Discretionary Revisions (which the author can choose to ignore) 
This is an interesting paper that gives the occasion for a deeper 
investigation on the brain-gut relationships in man. If the Authors would state precisely with the aid of a neuroradiologist and a neurophysiologist the topographic areas of the cervico medullary junction involved by the 
lesions, they should be able to single out the areas of vagal nuclei that 
control gastric motility and that are distinct from the areas of the vomiting center. The present case together with a similar report previously published in J Gastrointest Mot 1989;1:99 could contribute to a deeper 
knowledge of the central control of gastric motility. 
Reviewer's report 
 Gastroparesis secondary to a demyelinating disease: A Case Series Title: 
 1  10 November 2006 Version: Date: 
 Mauro Bortolotti Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
- How were the characteristics of the vomiting? Was it neurological? 
- Did the patients have signs of endocranic hypertension at the time of the vomiting start? - No details on the gastric emptying test were given. Was it done with a 
scintigraphic method? The values of the GE parameters before and after 
treatment should be given. 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
This is an interesting paper that gives the occasion for a deeper 
investigation on the brain-gut relationships in man. If the Authors would state precisely with the aid of a neuroradiologist and a neurophysiologist the topographic areas of the cervico medullary junction involved by the 
lesions, they should be able to single out the areas of vagal nuclei that 
control gastric motility and that are distinct from the areas of the vomiting center. The present case together with a similar report previously published in J Gastrointest Mot 1989;1:99 could contribute to a deeper 
knowledge of the central control of gastric motility. 
Please review this paper.
user
Reviewer's report 
 Gastroparesis secondary to a demyelinating disease: A Case Series Title: 
 1  10 November 2006 Version: Date: 
 Mauro Bortolotti Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
- How were the characteristics of the vomiting? Was it neurological? 
- Did the patients have signs of endocranic hypertension at the time of the vomiting start? - No details on the gastric emptying test were given. Was it done with a 
scintigraphic method? The values of the GE parameters before and after 
treatment should be given. 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
This is an interesting paper that gives the occasion for a deeper 
investigation on the brain-gut relationships in man. If the Authors would state precisely with the aid of a neuroradiologist and a neurophysiologist the topographic areas of the cervico medullary junction involved by the 
lesions, they should be able to single out the areas of vagal nuclei that 
control gastric motility and that are distinct from the areas of the vomiting center. The present case together with a similar report previously published in J Gastrointest Mot 1989;1:99 could contribute to a deeper 
knowledge of the central control of gastric motility. 
assistant