Title: Hepatic Arterial Infusion Chemotherapy plus Regorafenib in Advanced Colorectal
Cancer: A Real-World Retrospective Study
Version: 3 Date: 07 Apr 2022
Reviewer:  Hironaga Satake
Reviewer's report:
Thank you for submitting the revised version.
Please address the inadequate response to the following
Major
Although "patients with a history of systemic drug therapy" is specified as eligibility for this
study (P7. inclusioin criteria 4), in Table 1, N=23 patients have no history of prior therapy. I
think that these N=23 patients without prior treatment should be excluded from the analysis of
this research, and that this study should be analyzed with N=34 patients. How do you think?
P6-L155
Since the exclusion criterion is "cases without a history of systemic treatment (exclusioin criteria
5)", delete this sentence and and if the analysis includes cases with no history of systemic
chemotherapy, exclude them from the analysis.
Title: Hepatic Arterial Infusion Chemotherapy plus Regorafenib in Advanced Colorectal
Cancer: A Real-World Retrospective Study
Version: 3 Date: 07 Apr 2022
Reviewer:  Hironaga Satake
Reviewer's report:
Thank you for submitting the revised version.
Please address the inadequate response to the following
Major
Although "patients with a history of systemic drug therapy" is specified as eligibility for this
study (P7. inclusioin criteria 4), in Table 1, N=23 patients have no history of prior therapy. I
think that these N=23 patients without prior treatment should be excluded from the analysis of
this research, and that this study should be analyzed with N=34 patients. How do you think?
P6-L155
Since the exclusion criterion is "cases without a history of systemic treatment (exclusioin criteria
5)", delete this sentence and and if the analysis includes cases with no history of systemic
chemotherapy, exclude them from the analysis.
Please review this paper.
user
Title: Hepatic Arterial Infusion Chemotherapy plus Regorafenib in Advanced Colorectal
Cancer: A Real-World Retrospective Study
Version: 3 Date: 07 Apr 2022
Reviewer:  Hironaga Satake
Reviewer's report:
Thank you for submitting the revised version.
Please address the inadequate response to the following
Major
Although "patients with a history of systemic drug therapy" is specified as eligibility for this
study (P7. inclusioin criteria 4), in Table 1, N=23 patients have no history of prior therapy. I
think that these N=23 patients without prior treatment should be excluded from the analysis of
this research, and that this study should be analyzed with N=34 patients. How do you think?
P6-L155
Since the exclusion criterion is "cases without a history of systemic treatment (exclusioin criteria
5)", delete this sentence and and if the analysis includes cases with no history of systemic
chemotherapy, exclude them from the analysis.
assistant