Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract High and medium PRS apparently compared to low PRS? Although HLF is devided
in favoral anfavoral and intermediate in the results various dimensions were explored The two
sections should keep up  There presentation of intrplay between PRS, HFL and prediabetes is
a expected to be presented. Methods Pregnancy and SIRS presumably refered to the point if
data collection because pregnancy at any point in the past or SIRS from which the patient has
recovered fully I suppose are not exclusion criteria Oragma failure should be defined futher.
Has HLF been validated References should be provided Why authors have selected a 3 grade
stratification of their parameters? Why not a continous or dichotomous stratification? CRC
screening is first reported in statistics It should be defined in methods section Which method was
selected to compare separately CRC risk with HFL or PRS? Why HFL stratification proposed
in methods not used in the third paragraph? What is the utility to perform subgroup analysis
of various parameters of HFL and prediabetes? Multivariated analysis is not enough? Specific
gravity of each risk factor should be calculated?
Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract High and medium PRS apparently compared to low PRS? Although HLF is devided
in favoral anfavoral and intermediate in the results various dimensions were explored The two
sections should keep up  There presentation of intrplay between PRS, HFL and prediabetes is
a expected to be presented. Methods Pregnancy and SIRS presumably refered to the point if
data collection because pregnancy at any point in the past or SIRS from which the patient has
recovered fully I suppose are not exclusion criteria Oragma failure should be defined futher.
Has HLF been validated References should be provided Why authors have selected a 3 grade
stratification of their parameters? Why not a continous or dichotomous stratification? CRC
screening is first reported in statistics It should be defined in methods section Which method was
selected to compare separately CRC risk with HFL or PRS? Why HFL stratification proposed
in methods not used in the third paragraph? What is the utility to perform subgroup analysis
of various parameters of HFL and prediabetes? Multivariated analysis is not enough? Specific
gravity of each risk factor should be calculated?
Please review this paper.
user
Title: The additive interaction of healthy lifestyles and genetic susceptibility on colorectal
cancer risk in prediabetes: a large population-based prospective cohort study
Version: 3 Date: 14 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract High and medium PRS apparently compared to low PRS? Although HLF is devided
in favoral anfavoral and intermediate in the results various dimensions were explored The two
sections should keep up  There presentation of intrplay between PRS, HFL and prediabetes is
a expected to be presented. Methods Pregnancy and SIRS presumably refered to the point if
data collection because pregnancy at any point in the past or SIRS from which the patient has
recovered fully I suppose are not exclusion criteria Oragma failure should be defined futher.
Has HLF been validated References should be provided Why authors have selected a 3 grade
stratification of their parameters? Why not a continous or dichotomous stratification? CRC
screening is first reported in statistics It should be defined in methods section Which method was
selected to compare separately CRC risk with HFL or PRS? Why HFL stratification proposed
in methods not used in the third paragraph? What is the utility to perform subgroup analysis
of various parameters of HFL and prediabetes? Multivariated analysis is not enough? Specific
gravity of each risk factor should be calculated?
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