Reviewer ’s report  
Title: Attenuating the Rate of Total Body Fat Accumulation and Alleviating Liver Damage by  
Oral Administration of Vitamin D -enriched Edible Mushrooms in a Diet -induced Obesity 
Murine  Model is mediated by an Anti -inflammatory Paradigm Shift  
 
Version: 1 Date: 29 May 2017  
 
Reviewer: Eleonora Patsenker  
 
Reviewer's report:  
The authors nicely fulfilled the specific issues raised by me in previous version, but now, after 
some modifications (probably indicated by other reviewers) - some other "pro blems" appeared. 
The statistics described in the Results part ruin the whole beauty of the story and does not look 
good at all now. One has to rewrite it again. Most of it can just be deleted, as the way it's written 
- "For LE and LE+Vitamin D treated grou ps - p values < 0.05 OR all p values OR p values NS" - 
does not look professional or appropriate. Instead, all p values can be simply shown on the Figs 
with stars above the graphs/columns (wasn't it like that in the previous version?), with some 
explanatio n in the Fig legend (which is fine, actually, now):  *=p< 0.05, **=< 0.005, etc. No one 
wants to read this p and numbers through out the text (unless you want to emphasize something 
very significant in some cases!), especially, for the data which are not s hown..? What was the 
point to  describe  so much then?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequa tely supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommende d, please specify what aspects require further  
assessment in your comments  to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interest s 
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the pub lication of this  
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you cu rrently applying for any patents relating to the content of the  
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no co mpeting interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be po sted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be in cluded in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
Title: Attenuating the Rate of Total Body Fat Accumulation and Alleviating Liver Damage by  
Oral Administration of Vitamin D -enriched Edible Mushrooms in a Diet -induced Obesity 
Murine  Model is mediated by an Anti -inflammatory Paradigm Shift  
 
Version: 1 Date: 29 May 2017  
 
Reviewer: Eleonora Patsenker  
 
Reviewer's report:  
The authors nicely fulfilled the specific issues raised by me in previous version, but now, after 
some modifications (probably indicated by other reviewers) - some other "pro blems" appeared. 
The statistics described in the Results part ruin the whole beauty of the story and does not look 
good at all now. One has to rewrite it again. Most of it can just be deleted, as the way it's written 
- "For LE and LE+Vitamin D treated grou ps - p values < 0.05 OR all p values OR p values NS" - 
does not look professional or appropriate. Instead, all p values can be simply shown on the Figs 
with stars above the graphs/columns (wasn't it like that in the previous version?), with some 
explanatio n in the Fig legend (which is fine, actually, now):  *=p< 0.05, **=< 0.005, etc. No one 
wants to read this p and numbers through out the text (unless you want to emphasize something 
very significant in some cases!), especially, for the data which are not s hown..? What was the 
point to  describe  so much then?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequa tely supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommende d, please specify what aspects require further  
assessment in your comments  to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interest s 
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the pub lication of this  
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you cu rrently applying for any patents relating to the content of the  
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no co mpeting interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be po sted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be in cluded in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
Title: Attenuating the Rate of Total Body Fat Accumulation and Alleviating Liver Damage by  
Oral Administration of Vitamin D -enriched Edible Mushrooms in a Diet -induced Obesity 
Murine  Model is mediated by an Anti -inflammatory Paradigm Shift  
 
Version: 1 Date: 29 May 2017  
 
Reviewer: Eleonora Patsenker  
 
Reviewer's report:  
The authors nicely fulfilled the specific issues raised by me in previous version, but now, after 
some modifications (probably indicated by other reviewers) - some other "pro blems" appeared. 
The statistics described in the Results part ruin the whole beauty of the story and does not look 
good at all now. One has to rewrite it again. Most of it can just be deleted, as the way it's written 
- "For LE and LE+Vitamin D treated grou ps - p values < 0.05 OR all p values OR p values NS" - 
does not look professional or appropriate. Instead, all p values can be simply shown on the Figs 
with stars above the graphs/columns (wasn't it like that in the previous version?), with some 
explanatio n in the Fig legend (which is fine, actually, now):  *=p< 0.05, **=< 0.005, etc. No one 
wants to read this p and numbers through out the text (unless you want to emphasize something 
very significant in some cases!), especially, for the data which are not s hown..? What was the 
point to  describe  so much then?  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequa tely supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommende d, please specify what aspects require further  
assessment in your comments  to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interest s 
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the pub lication of this  
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you cu rrently applying for any patents relating to the content of the  
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no co mpeting interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be po sted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be in cluded in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant