Reviewer's report
Title:Risk Factors for Early and Delayed Post-Operative Bleeding after
Endoscopic Submucosal Dissection of Gastric Neoplasms, Including Patients
with Continued Use of Antithrombotic Agents
Version:2Date:21 July 2014
Reviewer: Tomoki Michida
Reviewer's report:
Major Compulsory Revisions
1. The analysis in Table 3 and 4 are uncertain. In Table 3, p-value of male
gender is 0.07 and it is included in multivariate analysis. In Table 4, that of
cession of antithrombotic drugs is 0.03 and it is not included in multivariate
analysis.
2. In Table 2, tumor factors included are only its location. Those such as depth,
size, and ulcer findings should be also assessed.
3. Sample size would be too small to evaluate risk of patients with of
antithrombotic drugs. There are many factors of which OR are over 3, however
there are no significant difference. The authors had better consider these points
in Discussion.
4. In case of 37 patients with cession of antithrombotic drugs, timing of restart of
antithrombotic drugs is important. According to Japanese guideline they are
restarted soon after the second look endoscopy. Timing of their restart would be
assessed more precisely than described as ‘within 5 days’
Minor Essential Revisions
Abstract; Why is this conclusion introduced such as the last sentence?
Methods 1st paragraph; Define epithelial neoplasia, please.
Methods 4th paragraph; Difference in endoscopic findings in second look
endoscopy between in patients with and without antithrombotic drugs
would be also assessed.
Results 3rd paragraph; In case of ESD, specimen size would be usually over
30mm.
Discussion 1st paragraph; There is no original data in it, so it had been better to
be concluded in Introduction.
Discussion 2nd paragraph; In this study, as antithrombotic therapy were
interrupted preoperatively in half of the patients with antithrombotic drugs, the
authors should assess about not only continued use of them but also interrupted
one.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Risk Factors for Early and Delayed Post-Operative Bleeding after
Endoscopic Submucosal Dissection of Gastric Neoplasms, Including Patients
with Continued Use of Antithrombotic Agents
Version:2Date:21 July 2014
Reviewer: Tomoki Michida
Reviewer's report:
Major Compulsory Revisions
1. The analysis in Table 3 and 4 are uncertain. In Table 3, p-value of male
gender is 0.07 and it is included in multivariate analysis. In Table 4, that of
cession of antithrombotic drugs is 0.03 and it is not included in multivariate
analysis.
2. In Table 2, tumor factors included are only its location. Those such as depth,
size, and ulcer findings should be also assessed.
3. Sample size would be too small to evaluate risk of patients with of
antithrombotic drugs. There are many factors of which OR are over 3, however
there are no significant difference. The authors had better consider these points
in Discussion.
4. In case of 37 patients with cession of antithrombotic drugs, timing of restart of
antithrombotic drugs is important. According to Japanese guideline they are
restarted soon after the second look endoscopy. Timing of their restart would be
assessed more precisely than described as ‘within 5 days’
Minor Essential Revisions
Abstract; Why is this conclusion introduced such as the last sentence?
Methods 1st paragraph; Define epithelial neoplasia, please.
Methods 4th paragraph; Difference in endoscopic findings in second look
endoscopy between in patients with and without antithrombotic drugs
would be also assessed.
Results 3rd paragraph; In case of ESD, specimen size would be usually over
30mm.
Discussion 1st paragraph; There is no original data in it, so it had been better to
be concluded in Introduction.
Discussion 2nd paragraph; In this study, as antithrombotic therapy were
interrupted preoperatively in half of the patients with antithrombotic drugs, the
authors should assess about not only continued use of them but also interrupted
one.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Risk Factors for Early and Delayed Post-Operative Bleeding after
Endoscopic Submucosal Dissection of Gastric Neoplasms, Including Patients
with Continued Use of Antithrombotic Agents
Version:2Date:21 July 2014
Reviewer: Tomoki Michida
Reviewer's report:
Major Compulsory Revisions
1. The analysis in Table 3 and 4 are uncertain. In Table 3, p-value of male
gender is 0.07 and it is included in multivariate analysis. In Table 4, that of
cession of antithrombotic drugs is 0.03 and it is not included in multivariate
analysis.
2. In Table 2, tumor factors included are only its location. Those such as depth,
size, and ulcer findings should be also assessed.
3. Sample size would be too small to evaluate risk of patients with of
antithrombotic drugs. There are many factors of which OR are over 3, however
there are no significant difference. The authors had better consider these points
in Discussion.
4. In case of 37 patients with cession of antithrombotic drugs, timing of restart of
antithrombotic drugs is important. According to Japanese guideline they are
restarted soon after the second look endoscopy. Timing of their restart would be
assessed more precisely than described as ‘within 5 days’
Minor Essential Revisions
Abstract; Why is this conclusion introduced such as the last sentence?
Methods 1st paragraph; Define epithelial neoplasia, please.
Methods 4th paragraph; Difference in endoscopic findings in second look
endoscopy between in patients with and without antithrombotic drugs
would be also assessed.
Results 3rd paragraph; In case of ESD, specimen size would be usually over
30mm.
Discussion 1st paragraph; There is no original data in it, so it had been better to
be concluded in Introduction.
Discussion 2nd paragraph; In this study, as antithrombotic therapy were
interrupted preoperatively in half of the patients with antithrombotic drugs, the
authors should assess about not only continued use of them but also interrupted
one.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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