Title: Prevalence and Predictors of Non-alcoholic Liver Disease on MRI among Patients with
Crohn's Disease
Version: 3 Date: 24 Feb 2022
Reviewer's report:
Dr. Qijin Hong et al. have reported prevalence of non-alcoholic fatty liver disease (NAFLD) in
Crohn’s disease (CD). The very interesting point is they develop a nomogram to instruct clinical
practice.
I have some questions and comments, however, that I believe the authors need to address, as
follows:
1. The nomogram created by the authors is very interesting, but the details of how to use it are
unclear. It is unclear what the 'points' in the first factor and the 'Total Points' are. They should
explain the detailed usage of this nomogram.
2. In their discussion, the authors suggest that the dysbiosis of gut bacteria may be involved in
the difference in prevalence of NASH in Crohn's disease, but the rationale for this needs to be
explained in detail.
1. There is no need for "liver" at the beginning of "alcholic liver fatty liver disease" in the third
line of the abstract.
2. They should put (NASH) after 'alcholic liver fatty liver disease' in the second line of the
abstract.
3. On page 2, line 7, 'enterography' should be 'elastograpy'.
4. On page 5, line 18, '86 patients' should be changed to '83 patients'.
5. There are no Figure Legends in this paper, but it would be easier for readers to understand
if you write an explanation for each figure.
Title: Prevalence and Predictors of Non-alcoholic Liver Disease on MRI among Patients with
Crohn's Disease
Version: 3 Date: 24 Feb 2022
Reviewer's report:
Dr. Qijin Hong et al. have reported prevalence of non-alcoholic fatty liver disease (NAFLD) in
Crohn’s disease (CD). The very interesting point is they develop a nomogram to instruct clinical
practice.
I have some questions and comments, however, that I believe the authors need to address, as
follows:
1. The nomogram created by the authors is very interesting, but the details of how to use it are
unclear. It is unclear what the 'points' in the first factor and the 'Total Points' are. They should
explain the detailed usage of this nomogram.
2. In their discussion, the authors suggest that the dysbiosis of gut bacteria may be involved in
the difference in prevalence of NASH in Crohn's disease, but the rationale for this needs to be
explained in detail.
1. There is no need for "liver" at the beginning of "alcholic liver fatty liver disease" in the third
line of the abstract.
2. They should put (NASH) after 'alcholic liver fatty liver disease' in the second line of the
abstract.
3. On page 2, line 7, 'enterography' should be 'elastograpy'.
4. On page 5, line 18, '86 patients' should be changed to '83 patients'.
5. There are no Figure Legends in this paper, but it would be easier for readers to understand
if you write an explanation for each figure.
Please review this paper.
user
Title: Prevalence and Predictors of Non-alcoholic Liver Disease on MRI among Patients with
Crohn's Disease
Version: 3 Date: 24 Feb 2022
Reviewer's report:
Dr. Qijin Hong et al. have reported prevalence of non-alcoholic fatty liver disease (NAFLD) in
Crohn’s disease (CD). The very interesting point is they develop a nomogram to instruct clinical
practice.
I have some questions and comments, however, that I believe the authors need to address, as
follows:
1. The nomogram created by the authors is very interesting, but the details of how to use it are
unclear. It is unclear what the 'points' in the first factor and the 'Total Points' are. They should
explain the detailed usage of this nomogram.
2. In their discussion, the authors suggest that the dysbiosis of gut bacteria may be involved in
the difference in prevalence of NASH in Crohn's disease, but the rationale for this needs to be
explained in detail.
1. There is no need for "liver" at the beginning of "alcholic liver fatty liver disease" in the third
line of the abstract.
2. They should put (NASH) after 'alcholic liver fatty liver disease' in the second line of the
abstract.
3. On page 2, line 7, 'enterography' should be 'elastograpy'.
4. On page 5, line 18, '86 patients' should be changed to '83 patients'.
5. There are no Figure Legends in this paper, but it would be easier for readers to understand
if you write an explanation for each figure.
assistant