Title: Racial or ethnic differences on treatment adherence and persistence among patients with
inflammatory bowel diseases initiated with biologic therapies
Version: 3 Date: 10 Jul 2022
Reviewer's report:
This is an interesting original article about the “Racial or ethnic differences on treatment
adherence and persistence among patients with inflammatory bowel diseases initiated with
biologic therapies „
There are some formal requirements that need to be corrected:
1. There are a few typo, please revise and correct them.
2. Please use the official section names: Introduction, Methods, Results, Discussion
I have a few points according to the article:
1. I think in the abstract the background only contains the aims. It would be more elegant to start
with this sentence from the introduction:
„In general, literature describing IBD among AA and other races is limited. Racial and ethnic
minorities continue to be underrepresented in IBD clinical trials.” and continue with: Our aim
was „to evaluate the association between race/ethnicity and treatment adherence and  persistence
among patients with Crohn’s disease (CD) or ulcerative colitis (UC) initiated with biologics. „
2. At the study design the dates are from 1/1/2016 to 06/30/2020. However ont he figure one
06/30/2019. Which is the correct?
3. Results: and the mean () age was 41.8 (16.4) years – pls correct
4. It would be useful an online only expanation map for those whom are not familier with the
US insurance system what means the „AA patients resided in the South region.” And a small
descreption whats the main difference between insurance types HMO, PPO, POS.
5. Can you explain the cause on figure 2 the Asian population has the best adherence at month
3, 6, 9, but  not at month 12.
6. I was wondering what is the reason between the CD and UC results. In the discussion the
authors mention: “One of the possible reasons for such differential findings could be attributed
to significant differences in the phenotypes particularly the most severe forms – perianal and
fistulizing disease in AA patients with CD compared with other races. More severe disease
would lead to better adherence to maximize the treatment effect but if less effective, to greater
discontinuation„ – if this is the reason than the discontinuation is a medical reason and a doctor
decision and we can’t relate to the patients socioeconomical status.
Title: Racial or ethnic differences on treatment adherence and persistence among patients with
inflammatory bowel diseases initiated with biologic therapies
Version: 3 Date: 10 Jul 2022
Reviewer's report:
This is an interesting original article about the “Racial or ethnic differences on treatment
adherence and persistence among patients with inflammatory bowel diseases initiated with
biologic therapies „
There are some formal requirements that need to be corrected:
1. There are a few typo, please revise and correct them.
2. Please use the official section names: Introduction, Methods, Results, Discussion
I have a few points according to the article:
1. I think in the abstract the background only contains the aims. It would be more elegant to start
with this sentence from the introduction:
„In general, literature describing IBD among AA and other races is limited. Racial and ethnic
minorities continue to be underrepresented in IBD clinical trials.” and continue with: Our aim
was „to evaluate the association between race/ethnicity and treatment adherence and  persistence
among patients with Crohn’s disease (CD) or ulcerative colitis (UC) initiated with biologics. „
2. At the study design the dates are from 1/1/2016 to 06/30/2020. However ont he figure one
06/30/2019. Which is the correct?
3. Results: and the mean () age was 41.8 (16.4) years – pls correct
4. It would be useful an online only expanation map for those whom are not familier with the
US insurance system what means the „AA patients resided in the South region.” And a small
descreption whats the main difference between insurance types HMO, PPO, POS.
5. Can you explain the cause on figure 2 the Asian population has the best adherence at month
3, 6, 9, but  not at month 12.
6. I was wondering what is the reason between the CD and UC results. In the discussion the
authors mention: “One of the possible reasons for such differential findings could be attributed
to significant differences in the phenotypes particularly the most severe forms – perianal and
fistulizing disease in AA patients with CD compared with other races. More severe disease
would lead to better adherence to maximize the treatment effect but if less effective, to greater
discontinuation„ – if this is the reason than the discontinuation is a medical reason and a doctor
decision and we can’t relate to the patients socioeconomical status.
Please review this paper.
user
Title: Racial or ethnic differences on treatment adherence and persistence among patients with
inflammatory bowel diseases initiated with biologic therapies
Version: 3 Date: 10 Jul 2022
Reviewer's report:
This is an interesting original article about the “Racial or ethnic differences on treatment
adherence and persistence among patients with inflammatory bowel diseases initiated with
biologic therapies „
There are some formal requirements that need to be corrected:
1. There are a few typo, please revise and correct them.
2. Please use the official section names: Introduction, Methods, Results, Discussion
I have a few points according to the article:
1. I think in the abstract the background only contains the aims. It would be more elegant to start
with this sentence from the introduction:
„In general, literature describing IBD among AA and other races is limited. Racial and ethnic
minorities continue to be underrepresented in IBD clinical trials.” and continue with: Our aim
was „to evaluate the association between race/ethnicity and treatment adherence and  persistence
among patients with Crohn’s disease (CD) or ulcerative colitis (UC) initiated with biologics. „
2. At the study design the dates are from 1/1/2016 to 06/30/2020. However ont he figure one
06/30/2019. Which is the correct?
3. Results: and the mean () age was 41.8 (16.4) years – pls correct
4. It would be useful an online only expanation map for those whom are not familier with the
US insurance system what means the „AA patients resided in the South region.” And a small
descreption whats the main difference between insurance types HMO, PPO, POS.
5. Can you explain the cause on figure 2 the Asian population has the best adherence at month
3, 6, 9, but  not at month 12.
6. I was wondering what is the reason between the CD and UC results. In the discussion the
authors mention: “One of the possible reasons for such differential findings could be attributed
to significant differences in the phenotypes particularly the most severe forms – perianal and
fistulizing disease in AA patients with CD compared with other races. More severe disease
would lead to better adherence to maximize the treatment effect but if less effective, to greater
discontinuation„ – if this is the reason than the discontinuation is a medical reason and a doctor
decision and we can’t relate to the patients socioeconomical status.
assistant