Reviewer's report
Title:Small invasive colon cancer with severe distant metastasis: A case report
Version: 3Date:11 February 2011
Reviewer: Ho-Kyung Chun
Reviewer's report:
In this manuscript Minori Matsumoto and coworkers describes a case of cervical
lymph node metastasis which was proven to originate from small colon cancer.
The way they traced the primary site was very interesting. I recommend the
authors to change the title of this manuscript.(severe metastasis is not a proper
term.)
Please clarify whether the patient had aspiration cytology or biopsy of the
cervical lymph node. (In the first paragraph of case presentation, "aspiration
cytology" was performed, whereas in the second paragraph "biopsy specimen"
was obtained.)
The tumor was 12mm in diameter, but had central depression and a severely
thickened stalk, which suggested direct cancer invasion to the deep submucosa.
The authors need to verify why they performed endoscopic submucosal resection
rather than a biopsy.
I believe that the patient had upper endoscope. Even though the result was
negative, it should be described.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Small invasive colon cancer with severe distant metastasis: A case report
Version: 3Date:11 February 2011
Reviewer: Ho-Kyung Chun
Reviewer's report:
In this manuscript Minori Matsumoto and coworkers describes a case of cervical
lymph node metastasis which was proven to originate from small colon cancer.
The way they traced the primary site was very interesting. I recommend the
authors to change the title of this manuscript.(severe metastasis is not a proper
term.)
Please clarify whether the patient had aspiration cytology or biopsy of the
cervical lymph node. (In the first paragraph of case presentation, "aspiration
cytology" was performed, whereas in the second paragraph "biopsy specimen"
was obtained.)
The tumor was 12mm in diameter, but had central depression and a severely
thickened stalk, which suggested direct cancer invasion to the deep submucosa.
The authors need to verify why they performed endoscopic submucosal resection
rather than a biopsy.
I believe that the patient had upper endoscope. Even though the result was
negative, it should be described.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Small invasive colon cancer with severe distant metastasis: A case report
Version: 3Date:11 February 2011
Reviewer: Ho-Kyung Chun
Reviewer's report:
In this manuscript Minori Matsumoto and coworkers describes a case of cervical
lymph node metastasis which was proven to originate from small colon cancer.
The way they traced the primary site was very interesting. I recommend the
authors to change the title of this manuscript.(severe metastasis is not a proper
term.)
Please clarify whether the patient had aspiration cytology or biopsy of the
cervical lymph node. (In the first paragraph of case presentation, "aspiration
cytology" was performed, whereas in the second paragraph "biopsy specimen"
was obtained.)
The tumor was 12mm in diameter, but had central depression and a severely
thickened stalk, which suggested direct cancer invasion to the deep submucosa.
The authors need to verify why they performed endoscopic submucosal resection
rather than a biopsy.
I believe that the patient had upper endoscope. Even though the result was
negative, it should be described.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant