Title: Clinico-pathological Characteristics of Obstructing Colorectal Cancer and its
Management Outcomes at a Tertiary Referral Center of Eastern Nepal
Version: 4 Date: 29 May 2022
Reviewer's report:
The revised manuscript did not solve my previous concerns satisfactorily. Instead, it bring new
issues.
1. In Figure 1, how can the authors diagnosis partial bowel obstruction or complete obstruction
via X-ray examination?  The figure 1 should be scheme, instead of Algorithm.
2. Page 7, the sample size calculation should be utilized to solve the scientific problems raised
by the authors, instead of giving the excuse for limited sample size. The authors should carefully
check their statement. The calculation methods for identifying sample size of clinical trials were
reported by many publications (e.g. 10.1002/ncp.10674).
3. The authors stated that "The treatments provided at our center and their outcomes are not
inferior to that of the developed world". However, no comparison study could be found in current
version of  manuscript. The SEER database or other open-access databases should be included.
4. The current study included 28 CRC patients. However, no ethic approval number was
provided in the manuscript.
5. The language was poor. The manuscript is arcane for most readers.
Title: Clinico-pathological Characteristics of Obstructing Colorectal Cancer and its
Management Outcomes at a Tertiary Referral Center of Eastern Nepal
Version: 4 Date: 29 May 2022
Reviewer's report:
The revised manuscript did not solve my previous concerns satisfactorily. Instead, it bring new
issues.
1. In Figure 1, how can the authors diagnosis partial bowel obstruction or complete obstruction
via X-ray examination?  The figure 1 should be scheme, instead of Algorithm.
2. Page 7, the sample size calculation should be utilized to solve the scientific problems raised
by the authors, instead of giving the excuse for limited sample size. The authors should carefully
check their statement. The calculation methods for identifying sample size of clinical trials were
reported by many publications (e.g. 10.1002/ncp.10674).
3. The authors stated that "The treatments provided at our center and their outcomes are not
inferior to that of the developed world". However, no comparison study could be found in current
version of  manuscript. The SEER database or other open-access databases should be included.
4. The current study included 28 CRC patients. However, no ethic approval number was
provided in the manuscript.
5. The language was poor. The manuscript is arcane for most readers.
Please review this paper.
user
Title: Clinico-pathological Characteristics of Obstructing Colorectal Cancer and its
Management Outcomes at a Tertiary Referral Center of Eastern Nepal
Version: 4 Date: 29 May 2022
Reviewer's report:
The revised manuscript did not solve my previous concerns satisfactorily. Instead, it bring new
issues.
1. In Figure 1, how can the authors diagnosis partial bowel obstruction or complete obstruction
via X-ray examination?  The figure 1 should be scheme, instead of Algorithm.
2. Page 7, the sample size calculation should be utilized to solve the scientific problems raised
by the authors, instead of giving the excuse for limited sample size. The authors should carefully
check their statement. The calculation methods for identifying sample size of clinical trials were
reported by many publications (e.g. 10.1002/ncp.10674).
3. The authors stated that "The treatments provided at our center and their outcomes are not
inferior to that of the developed world". However, no comparison study could be found in current
version of  manuscript. The SEER database or other open-access databases should be included.
4. The current study included 28 CRC patients. However, no ethic approval number was
provided in the manuscript.
5. The language was poor. The manuscript is arcane for most readers.
assistant