Title: The influence of muscle performance and fatigue on prognosis in patients with
compensated liver disease
Version: 2 Date: 06 Feb 2023
Reviewer:  Gloria Sanchez-antolin
Reviewer's report:
The authors  tried to know the impact of muscle function  on prognosis in compensated CLD ,
because it is  not clear.
They only found the cut-off of 14 seconds for the timed up and go test with a significant
correlation with survival (p=0.026), and it was also associated with transplant free survival
(p<0.001).
Perhaps could be useful to know  the blood test data in the patients to correlate better the muscle
test with the liver function test.
But it is a prospective study with a large cohort of patients and I consider interesting  that
researchers and liver clinics could realize the influence of muscle function and sarcopenia in the
prognosis of liver patients and take care about this factor.
Title: The influence of muscle performance and fatigue on prognosis in patients with
compensated liver disease
Version: 2 Date: 06 Feb 2023
Reviewer:  Gloria Sanchez-antolin
Reviewer's report:
The authors  tried to know the impact of muscle function  on prognosis in compensated CLD ,
because it is  not clear.
They only found the cut-off of 14 seconds for the timed up and go test with a significant
correlation with survival (p=0.026), and it was also associated with transplant free survival
(p<0.001).
Perhaps could be useful to know  the blood test data in the patients to correlate better the muscle
test with the liver function test.
But it is a prospective study with a large cohort of patients and I consider interesting  that
researchers and liver clinics could realize the influence of muscle function and sarcopenia in the
prognosis of liver patients and take care about this factor.
Please review this paper.
user
Title: The influence of muscle performance and fatigue on prognosis in patients with
compensated liver disease
Version: 2 Date: 06 Feb 2023
Reviewer:  Gloria Sanchez-antolin
Reviewer's report:
The authors  tried to know the impact of muscle function  on prognosis in compensated CLD ,
because it is  not clear.
They only found the cut-off of 14 seconds for the timed up and go test with a significant
correlation with survival (p=0.026), and it was also associated with transplant free survival
(p<0.001).
Perhaps could be useful to know  the blood test data in the patients to correlate better the muscle
test with the liver function test.
But it is a prospective study with a large cohort of patients and I consider interesting  that
researchers and liver clinics could realize the influence of muscle function and sarcopenia in the
prognosis of liver patients and take care about this factor.
assistant