Reviewer's report
Title:Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease
population
Version: 1Date:15 June 2011
Reviewer: Gary Abrams
Reviewer's report:
Dr Sumida and colleagues performed a nice study comparing multiple
non-invasive mathematical methods for assessing the presence or absence of
advanced fibrosis in NAFLD. The data is well presented and appropriate
limitations are discussed.
Discretionary Revisions- Although the authors mentioned the limitations of liver
biopsy sampling errors, it would be helpful if they provide the length of the
biopsies as well as the number of portal tracts to assess the adequacy of the liver
tissue obtained (most studies would require 20mm and >10 PTs). It would also
be helpful to determine if there were significant differences between the liver
biopsy samples with regards to the lower and upper cut-off values
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease
population
Version: 1Date:15 June 2011
Reviewer: Gary Abrams
Reviewer's report:
Dr Sumida and colleagues performed a nice study comparing multiple
non-invasive mathematical methods for assessing the presence or absence of
advanced fibrosis in NAFLD. The data is well presented and appropriate
limitations are discussed.
Discretionary Revisions- Although the authors mentioned the limitations of liver
biopsy sampling errors, it would be helpful if they provide the length of the
biopsies as well as the number of portal tracts to assess the adequacy of the liver
tissue obtained (most studies would require 20mm and >10 PTs). It would also
be helpful to determine if there were significant differences between the liver
biopsy samples with regards to the lower and upper cut-off values
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Validation of the FIB4 index in a Japanese nonalcoholic fatty liver disease
population
Version: 1Date:15 June 2011
Reviewer: Gary Abrams
Reviewer's report:
Dr Sumida and colleagues performed a nice study comparing multiple
non-invasive mathematical methods for assessing the presence or absence of
advanced fibrosis in NAFLD. The data is well presented and appropriate
limitations are discussed.
Discretionary Revisions- Although the authors mentioned the limitations of liver
biopsy sampling errors, it would be helpful if they provide the length of the
biopsies as well as the number of portal tracts to assess the adequacy of the liver
tissue obtained (most studies would require 20mm and >10 PTs). It would also
be helpful to determine if there were significant differences between the liver
biopsy samples with regards to the lower and upper cut-off values
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant