Title: Neutrophil-Derived Ratios as Predictors of Short-Term Mortality in HBV-Associated
Decompensated Cirrhosis
Version: 0 Date: 27 Mar 2025
Reviewer's report:
Xiang and colleagues present an interesting retrospective observational study about the
performance of several new blood-cell based composed inflammation indices for discriminating
HBV-associated decompensated cirrhosis, a fatal liver infectious disease caused by Hepatitis-B
virus. The statistical design is valid and the results interesting. However, I have some suggestions
to make to improve the quality of the manuscript.
1) Why did the author choose 30 days as the research endpoint (rather than 3 month, 6 month
or 1 yr mortality)? Please, justify.
2) Moreover, authors should provide the causes of mortality.
3) Had the patients received antiviral HBV therapy? If yes, which?
4) What is the HBV prevalence? How many clinical records did the authors browse? What was
the time frame (month and year)?
5) Limitations of the study should be reported in a more extensive way, including the lack of
a validation cohort.
Title: Neutrophil-Derived Ratios as Predictors of Short-Term Mortality in HBV-Associated
Decompensated Cirrhosis
Version: 0 Date: 27 Mar 2025
Reviewer's report:
Xiang and colleagues present an interesting retrospective observational study about the
performance of several new blood-cell based composed inflammation indices for discriminating
HBV-associated decompensated cirrhosis, a fatal liver infectious disease caused by Hepatitis-B
virus. The statistical design is valid and the results interesting. However, I have some suggestions
to make to improve the quality of the manuscript.
1) Why did the author choose 30 days as the research endpoint (rather than 3 month, 6 month
or 1 yr mortality)? Please, justify.
2) Moreover, authors should provide the causes of mortality.
3) Had the patients received antiviral HBV therapy? If yes, which?
4) What is the HBV prevalence? How many clinical records did the authors browse? What was
the time frame (month and year)?
5) Limitations of the study should be reported in a more extensive way, including the lack of
a validation cohort.
Please review this paper.
user
Title: Neutrophil-Derived Ratios as Predictors of Short-Term Mortality in HBV-Associated
Decompensated Cirrhosis
Version: 0 Date: 27 Mar 2025
Reviewer's report:
Xiang and colleagues present an interesting retrospective observational study about the
performance of several new blood-cell based composed inflammation indices for discriminating
HBV-associated decompensated cirrhosis, a fatal liver infectious disease caused by Hepatitis-B
virus. The statistical design is valid and the results interesting. However, I have some suggestions
to make to improve the quality of the manuscript.
1) Why did the author choose 30 days as the research endpoint (rather than 3 month, 6 month
or 1 yr mortality)? Please, justify.
2) Moreover, authors should provide the causes of mortality.
3) Had the patients received antiviral HBV therapy? If yes, which?
4) What is the HBV prevalence? How many clinical records did the authors browse? What was
the time frame (month and year)?
5) Limitations of the study should be reported in a more extensive way, including the lack of
a validation cohort.
assistant