Title: Serum liver fibrosis markers predict hepatic decompensation in compensated cirrhosis
Version: 2 Date: 11 Jun 2023
Reviewer's report:
Comments: The authors assessed whether the serum liver fibrosis markers are predictive of the
occurrence of hepatic decompensation in 688 cirrhotic patients with varying etiologies. They
showed that collagen IV (CIV) is reliable predictor for liver decompensation. However, there
are some problems that should be addressed or altered.
#1#In the Discussion section, the authors said "Only a small number of studies for these markers
and their combination were designed to assess disease progression [31-34]". However, reference
33 suggested that CIV, LN, and HA levels were significantly associated with the severity of
liver dysfunction, but might be inappropriate for the prognostic assessment of liver cirrhosis.
You should cite them more accurately.
#2#In the Discussion section, the authors said " In the Discussion section, the authors said "We
assessed the three different decompensation events (ascites, esophageal bleeding, and hepatic
encephalopathy) simultaneously". Please support the above description by adding relevant
references.
#3#In the Discussion section, the authors said "We assessed the three different decompensation
events (ascites, esophageal bleeding, and hepatic encephalopathy) simultaneously". The word
"hepatic encephalopathy" should be revised as "HE".
#4#The conclusion section should be supplemented in the main text.
#5#The description regarding the post-hoc Bonferroni method and Cochran-Armitage trend test
should be recorded in the Materials and Methods section.
#6#The description of staging of HE, FIB-4 index and MELD score should be supplemented in
the Materials and Methods section.
#7#Please add the titles of Figures 1 and Figures 2.
Title: Serum liver fibrosis markers predict hepatic decompensation in compensated cirrhosis
Version: 2 Date: 11 Jun 2023
Reviewer's report:
Comments: The authors assessed whether the serum liver fibrosis markers are predictive of the
occurrence of hepatic decompensation in 688 cirrhotic patients with varying etiologies. They
showed that collagen IV (CIV) is reliable predictor for liver decompensation. However, there
are some problems that should be addressed or altered.
#1#In the Discussion section, the authors said "Only a small number of studies for these markers
and their combination were designed to assess disease progression [31-34]". However, reference
33 suggested that CIV, LN, and HA levels were significantly associated with the severity of
liver dysfunction, but might be inappropriate for the prognostic assessment of liver cirrhosis.
You should cite them more accurately.
#2#In the Discussion section, the authors said " In the Discussion section, the authors said "We
assessed the three different decompensation events (ascites, esophageal bleeding, and hepatic
encephalopathy) simultaneously". Please support the above description by adding relevant
references.
#3#In the Discussion section, the authors said "We assessed the three different decompensation
events (ascites, esophageal bleeding, and hepatic encephalopathy) simultaneously". The word
"hepatic encephalopathy" should be revised as "HE".
#4#The conclusion section should be supplemented in the main text.
#5#The description regarding the post-hoc Bonferroni method and Cochran-Armitage trend test
should be recorded in the Materials and Methods section.
#6#The description of staging of HE, FIB-4 index and MELD score should be supplemented in
the Materials and Methods section.
#7#Please add the titles of Figures 1 and Figures 2.
Please review this paper.
user
Title: Serum liver fibrosis markers predict hepatic decompensation in compensated cirrhosis
Version: 2 Date: 11 Jun 2023
Reviewer's report:
Comments: The authors assessed whether the serum liver fibrosis markers are predictive of the
occurrence of hepatic decompensation in 688 cirrhotic patients with varying etiologies. They
showed that collagen IV (CIV) is reliable predictor for liver decompensation. However, there
are some problems that should be addressed or altered.
#1#In the Discussion section, the authors said "Only a small number of studies for these markers
and their combination were designed to assess disease progression [31-34]". However, reference
33 suggested that CIV, LN, and HA levels were significantly associated with the severity of
liver dysfunction, but might be inappropriate for the prognostic assessment of liver cirrhosis.
You should cite them more accurately.
#2#In the Discussion section, the authors said " In the Discussion section, the authors said "We
assessed the three different decompensation events (ascites, esophageal bleeding, and hepatic
encephalopathy) simultaneously". Please support the above description by adding relevant
references.
#3#In the Discussion section, the authors said "We assessed the three different decompensation
events (ascites, esophageal bleeding, and hepatic encephalopathy) simultaneously". The word
"hepatic encephalopathy" should be revised as "HE".
#4#The conclusion section should be supplemented in the main text.
#5#The description regarding the post-hoc Bonferroni method and Cochran-Armitage trend test
should be recorded in the Materials and Methods section.
#6#The description of staging of HE, FIB-4 index and MELD score should be supplemented in
the Materials and Methods section.
#7#Please add the titles of Figures 1 and Figures 2.
assistant