Title: The early biomarker of immature granulocyte count in predicting right-side colonic
complicated acute diverticulitis: A retrospective cohort study
Version: 2 Date: 04 Sep 2024
Reviewer's report:
Thank you for allowing me to review this manuscript. In this study, the authors aim to identify
the importance of immature granulocyte count in the early prediction of complicated acute
diverticulitis, a crucial aspect that could significantly impact clinical practice. The study presents
clear objectives and an adequate methodology. However, I have some questions that I would
like the authors to clarify:
1. For sample selection, were patients with hematological diseases or specific treatment that will
alter the leukocyte count excluded? If so, it is recommended that this be indicated within the
exclusion criteria.
2. Some studies have observed that comorbidities are predictive factors of severe diverticulitis.
What is the association of comorbidities with complicated acute diverticulitis in your study?
3. The authors do not indicate in the study whether the episode of acute diverticulitis analyzed
was the first episode or whether the patient had had previous episodes. Considering that some
studies have observed the first episode of diverticulitis is a predictive factor of severity. Is it
possible to have this variable available and analyze its association with complicated diverticulitis
in the analyzed sample?
4. From the results and Table 2, it is clear that in the univariate analysis, BMI had a significant
correlation with complicated acute diverticulitis and that in the multivariate analysis, the
correlation was not significant. With the data in Table 2, it is confusing to identify whether the
values in the table are from the univariate or multivariate analysis. It is recommended that the
results of the univariate and multivariate analysis be expressed separately for each variable.
Title: The early biomarker of immature granulocyte count in predicting right-side colonic
complicated acute diverticulitis: A retrospective cohort study
Version: 2 Date: 04 Sep 2024
Reviewer's report:
Thank you for allowing me to review this manuscript. In this study, the authors aim to identify
the importance of immature granulocyte count in the early prediction of complicated acute
diverticulitis, a crucial aspect that could significantly impact clinical practice. The study presents
clear objectives and an adequate methodology. However, I have some questions that I would
like the authors to clarify:
1. For sample selection, were patients with hematological diseases or specific treatment that will
alter the leukocyte count excluded? If so, it is recommended that this be indicated within the
exclusion criteria.
2. Some studies have observed that comorbidities are predictive factors of severe diverticulitis.
What is the association of comorbidities with complicated acute diverticulitis in your study?
3. The authors do not indicate in the study whether the episode of acute diverticulitis analyzed
was the first episode or whether the patient had had previous episodes. Considering that some
studies have observed the first episode of diverticulitis is a predictive factor of severity. Is it
possible to have this variable available and analyze its association with complicated diverticulitis
in the analyzed sample?
4. From the results and Table 2, it is clear that in the univariate analysis, BMI had a significant
correlation with complicated acute diverticulitis and that in the multivariate analysis, the
correlation was not significant. With the data in Table 2, it is confusing to identify whether the
values in the table are from the univariate or multivariate analysis. It is recommended that the
results of the univariate and multivariate analysis be expressed separately for each variable.
Please review this paper.
user
Title: The early biomarker of immature granulocyte count in predicting right-side colonic
complicated acute diverticulitis: A retrospective cohort study
Version: 2 Date: 04 Sep 2024
Reviewer's report:
Thank you for allowing me to review this manuscript. In this study, the authors aim to identify
the importance of immature granulocyte count in the early prediction of complicated acute
diverticulitis, a crucial aspect that could significantly impact clinical practice. The study presents
clear objectives and an adequate methodology. However, I have some questions that I would
like the authors to clarify:
1. For sample selection, were patients with hematological diseases or specific treatment that will
alter the leukocyte count excluded? If so, it is recommended that this be indicated within the
exclusion criteria.
2. Some studies have observed that comorbidities are predictive factors of severe diverticulitis.
What is the association of comorbidities with complicated acute diverticulitis in your study?
3. The authors do not indicate in the study whether the episode of acute diverticulitis analyzed
was the first episode or whether the patient had had previous episodes. Considering that some
studies have observed the first episode of diverticulitis is a predictive factor of severity. Is it
possible to have this variable available and analyze its association with complicated diverticulitis
in the analyzed sample?
4. From the results and Table 2, it is clear that in the univariate analysis, BMI had a significant
correlation with complicated acute diverticulitis and that in the multivariate analysis, the
correlation was not significant. With the data in Table 2, it is confusing to identify whether the
values in the table are from the univariate or multivariate analysis. It is recommended that the
results of the univariate and multivariate analysis be expressed separately for each variable.
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