Reviewer's report
Title:Meta-analysis of Percutaneous Radiofrequency Ablation versus Ethanol
Injection in Hepatocellular Carcinoma.
Version: 1Date:19 January 2009
Reviewer: Kazutaka Kurokohchi
Reviewer's report:
Review RE: Meta-analysis of percutaneous radiofrequency ablation versus
ethanol injection in hepatocellar carcinoma by Bouza et. al.
The authors analyzed systemic reviews and meta-analyses of randomized
control trials of hepatocellular carcinoma treated with RFA and PEI and
concluded that RFA is superior to PEI in terms of better survival and local control
of disease. However, the higher rates of adverse events are displayed in the RFA
treatment.
Analyzed systematic reviews are appropriately selected. Both of method for
analysis and analyzed item focused on are also appropriate. Therefore, this
manuscript should be finally published in the BMC Gastroenterology.
Although it is mentioned in the manuscript regarding the adverse effects of RFA
and PEI, those effects on the hepatic capacity are not mentioned. As everyone
knows, RFA treatment sometimes affects hepatic capacity of cirrhotic liver
leading to decrease of the level of albumin and administration of amino acids is
helpful to prevent the decrease of albumin level. Thus, it is likely to be better to
address regarding the effect of RFA on the hepatic capacity somewhere in the
manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Meta-analysis of Percutaneous Radiofrequency Ablation versus Ethanol
Injection in Hepatocellular Carcinoma.
Version: 1Date:19 January 2009
Reviewer: Kazutaka Kurokohchi
Reviewer's report:
Review RE: Meta-analysis of percutaneous radiofrequency ablation versus
ethanol injection in hepatocellar carcinoma by Bouza et. al.
The authors analyzed systemic reviews and meta-analyses of randomized
control trials of hepatocellular carcinoma treated with RFA and PEI and
concluded that RFA is superior to PEI in terms of better survival and local control
of disease. However, the higher rates of adverse events are displayed in the RFA
treatment.
Analyzed systematic reviews are appropriately selected. Both of method for
analysis and analyzed item focused on are also appropriate. Therefore, this
manuscript should be finally published in the BMC Gastroenterology.
Although it is mentioned in the manuscript regarding the adverse effects of RFA
and PEI, those effects on the hepatic capacity are not mentioned. As everyone
knows, RFA treatment sometimes affects hepatic capacity of cirrhotic liver
leading to decrease of the level of albumin and administration of amino acids is
helpful to prevent the decrease of albumin level. Thus, it is likely to be better to
address regarding the effect of RFA on the hepatic capacity somewhere in the
manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Meta-analysis of Percutaneous Radiofrequency Ablation versus Ethanol
Injection in Hepatocellular Carcinoma.
Version: 1Date:19 January 2009
Reviewer: Kazutaka Kurokohchi
Reviewer's report:
Review RE: Meta-analysis of percutaneous radiofrequency ablation versus
ethanol injection in hepatocellar carcinoma by Bouza et. al.
The authors analyzed systemic reviews and meta-analyses of randomized
control trials of hepatocellular carcinoma treated with RFA and PEI and
concluded that RFA is superior to PEI in terms of better survival and local control
of disease. However, the higher rates of adverse events are displayed in the RFA
treatment.
Analyzed systematic reviews are appropriately selected. Both of method for
analysis and analyzed item focused on are also appropriate. Therefore, this
manuscript should be finally published in the BMC Gastroenterology.
Although it is mentioned in the manuscript regarding the adverse effects of RFA
and PEI, those effects on the hepatic capacity are not mentioned. As everyone
knows, RFA treatment sometimes affects hepatic capacity of cirrhotic liver
leading to decrease of the level of albumin and administration of amino acids is
helpful to prevent the decrease of albumin level. Thus, it is likely to be better to
address regarding the effect of RFA on the hepatic capacity somewhere in the
manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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