Title: INTRAVENOUS SEDATION DURING ESOPHAGOGASTRODUODENOSCOPY IS
ASSOCIATED WITH A REDUCED RISK OF MISSED GASTRIC CANCER
Version: 1 Date: 09 Mar 2025
Reviewer's report:
•  This is a small, single-center retrospective study.
•  The Introduction and Discussion sections are too long.
•  The study includes patients with lymphoma and GIST, but their risk of developing
metachronous cancer differs from that of gastric cancer.
•  It is unclear why the study population was limited to patients with tumors identified during
endoscopy. There is a mismatch between the general aim of investigating factors contributing
to the missed diagnosis of gastric cancer and the specific study design and objectives.
•  Table 2 is insufficient. The results of both univariate and multivariate analyses regarding
predictors of metachronous gastric cancer should be included.
•  Based on the current findings, concluding that EGD without sedation is a risk factor for
metachronous gastric cancer is an overstatement. This is because there are baseline differences
between patients who underwent EGD with and without sedation, and the study is not a
randomized controlled trial.
•  Even if Helicobacter pylori infection status could not be assessed, the degree of gastric mucosal
atrophy should have been evaluated as an important factor potentially associated with gastric
cancer development.
Title: INTRAVENOUS SEDATION DURING ESOPHAGOGASTRODUODENOSCOPY IS
ASSOCIATED WITH A REDUCED RISK OF MISSED GASTRIC CANCER
Version: 1 Date: 09 Mar 2025
Reviewer's report:
•  This is a small, single-center retrospective study.
•  The Introduction and Discussion sections are too long.
•  The study includes patients with lymphoma and GIST, but their risk of developing
metachronous cancer differs from that of gastric cancer.
•  It is unclear why the study population was limited to patients with tumors identified during
endoscopy. There is a mismatch between the general aim of investigating factors contributing
to the missed diagnosis of gastric cancer and the specific study design and objectives.
•  Table 2 is insufficient. The results of both univariate and multivariate analyses regarding
predictors of metachronous gastric cancer should be included.
•  Based on the current findings, concluding that EGD without sedation is a risk factor for
metachronous gastric cancer is an overstatement. This is because there are baseline differences
between patients who underwent EGD with and without sedation, and the study is not a
randomized controlled trial.
•  Even if Helicobacter pylori infection status could not be assessed, the degree of gastric mucosal
atrophy should have been evaluated as an important factor potentially associated with gastric
cancer development.
Please review this paper.
user
Title: INTRAVENOUS SEDATION DURING ESOPHAGOGASTRODUODENOSCOPY IS
ASSOCIATED WITH A REDUCED RISK OF MISSED GASTRIC CANCER
Version: 1 Date: 09 Mar 2025
Reviewer's report:
•  This is a small, single-center retrospective study.
•  The Introduction and Discussion sections are too long.
•  The study includes patients with lymphoma and GIST, but their risk of developing
metachronous cancer differs from that of gastric cancer.
•  It is unclear why the study population was limited to patients with tumors identified during
endoscopy. There is a mismatch between the general aim of investigating factors contributing
to the missed diagnosis of gastric cancer and the specific study design and objectives.
•  Table 2 is insufficient. The results of both univariate and multivariate analyses regarding
predictors of metachronous gastric cancer should be included.
•  Based on the current findings, concluding that EGD without sedation is a risk factor for
metachronous gastric cancer is an overstatement. This is because there are baseline differences
between patients who underwent EGD with and without sedation, and the study is not a
randomized controlled trial.
•  Even if Helicobacter pylori infection status could not be assessed, the degree of gastric mucosal
atrophy should have been evaluated as an important factor potentially associated with gastric
cancer development.
assistant