Title: Preoperative Platelet-Lymphocyte Ratio (PLR) as a Prognostic Inflammation Biomarker
in Asian HIV-Infected Patients with Gastric Cancer: A Single-Center Study
Version: 1 Date: 10 Feb 2023
Reviewer's report:
The report is detailed, but two major limitations exist that dampen enthusiasm for the report:
(1) Both the Introduction and Discussion draw attention to the potential that these data can
guide therapeutic decisions.  However, no such conclusions can be drawn from a comparison of
inflammatory markers and overall survival when the treatments given were standard, and when
the analysis conducted was an association analysis rather than a predictive/prognostic one.
(2) The lack of an HIV-negative comparison group is a major weakness since the findings are not
surprising and have been shown for many other tumors in HIV-negative patients.  It would be
important to understand if the associations between inflammatory markers and overall survival
differ by HIV status.
Title: Preoperative Platelet-Lymphocyte Ratio (PLR) as a Prognostic Inflammation Biomarker
in Asian HIV-Infected Patients with Gastric Cancer: A Single-Center Study
Version: 1 Date: 10 Feb 2023
Reviewer's report:
The report is detailed, but two major limitations exist that dampen enthusiasm for the report:
(1) Both the Introduction and Discussion draw attention to the potential that these data can
guide therapeutic decisions.  However, no such conclusions can be drawn from a comparison of
inflammatory markers and overall survival when the treatments given were standard, and when
the analysis conducted was an association analysis rather than a predictive/prognostic one.
(2) The lack of an HIV-negative comparison group is a major weakness since the findings are not
surprising and have been shown for many other tumors in HIV-negative patients.  It would be
important to understand if the associations between inflammatory markers and overall survival
differ by HIV status.
Please review this paper.
user
Title: Preoperative Platelet-Lymphocyte Ratio (PLR) as a Prognostic Inflammation Biomarker
in Asian HIV-Infected Patients with Gastric Cancer: A Single-Center Study
Version: 1 Date: 10 Feb 2023
Reviewer's report:
The report is detailed, but two major limitations exist that dampen enthusiasm for the report:
(1) Both the Introduction and Discussion draw attention to the potential that these data can
guide therapeutic decisions.  However, no such conclusions can be drawn from a comparison of
inflammatory markers and overall survival when the treatments given were standard, and when
the analysis conducted was an association analysis rather than a predictive/prognostic one.
(2) The lack of an HIV-negative comparison group is a major weakness since the findings are not
surprising and have been shown for many other tumors in HIV-negative patients.  It would be
important to understand if the associations between inflammatory markers and overall survival
differ by HIV status.
assistant