Title: Causal relationship between Hypothyroidism and Ulcerative Colitis: a Bidirectional
Mendelian Randomization study
Version: 3 Date: 22 Aug 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below:
- Addressing potential pleiotropy, could significantly enhance the reproducibility and robustness
of your work. This could involve detailing the specific statistical techniques used, the rationale
behind their selection, and how potential sources of bias were accounted for.
-To further fortify the robustness of your method, it is advisable to consider conducting
additional sensitivity analyses and employing methods to validate the genetic instruments,
thereby ensuring the reliability and accuracy of your findings.
-Enhanced clarity and granularity on how hypothyroidism and ulcerative colitis were precisely
defined could significantly bolster the reliability and accuracy of your outcome measures, thus
fortifying the robustness of your study.
Title: Causal relationship between Hypothyroidism and Ulcerative Colitis: a Bidirectional
Mendelian Randomization study
Version: 3 Date: 22 Aug 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below:
- Addressing potential pleiotropy, could significantly enhance the reproducibility and robustness
of your work. This could involve detailing the specific statistical techniques used, the rationale
behind their selection, and how potential sources of bias were accounted for.
-To further fortify the robustness of your method, it is advisable to consider conducting
additional sensitivity analyses and employing methods to validate the genetic instruments,
thereby ensuring the reliability and accuracy of your findings.
-Enhanced clarity and granularity on how hypothyroidism and ulcerative colitis were precisely
defined could significantly bolster the reliability and accuracy of your outcome measures, thus
fortifying the robustness of your study.
Please review this paper.
user
Title: Causal relationship between Hypothyroidism and Ulcerative Colitis: a Bidirectional
Mendelian Randomization study
Version: 3 Date: 22 Aug 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below:
- Addressing potential pleiotropy, could significantly enhance the reproducibility and robustness
of your work. This could involve detailing the specific statistical techniques used, the rationale
behind their selection, and how potential sources of bias were accounted for.
-To further fortify the robustness of your method, it is advisable to consider conducting
additional sensitivity analyses and employing methods to validate the genetic instruments,
thereby ensuring the reliability and accuracy of your findings.
-Enhanced clarity and granularity on how hypothyroidism and ulcerative colitis were precisely
defined could significantly bolster the reliability and accuracy of your outcome measures, thus
fortifying the robustness of your study.
assistant