Title: Intestinal fatty acid binding protein is a disease biomarker in paediatric coeliac disease
and Crohn’s disease
Version: 3 Date: 22 Mar 2022
Reviewer's report:
Thank you for allowing me to review this revised version of the manuscript.
The Authors have carefully addressed the majority of the points raised by me and also by
reviewer 1.
I only still have a few concerns about the  methodology for assessing adherence to a GFD in this
pediatric cohort. I totally understand the aspect about follow-up duodenal biopsies. Assessing
GFD adherence is certainly difficult in adults and it can be even more difficult in children. I see
the points related to Authors' clinical experience and the growing interest on GIPs. However,
GIPs can only identify traces of gluten ingested within 48-72 hours before the test and cannot
be entirely representative of the "whole" degree of adherence. I believe this is a relevant aspect
and I think this should be discussed among the limits of the study.
Title: Intestinal fatty acid binding protein is a disease biomarker in paediatric coeliac disease
and Crohn’s disease
Version: 3 Date: 22 Mar 2022
Reviewer's report:
Thank you for allowing me to review this revised version of the manuscript.
The Authors have carefully addressed the majority of the points raised by me and also by
reviewer 1.
I only still have a few concerns about the  methodology for assessing adherence to a GFD in this
pediatric cohort. I totally understand the aspect about follow-up duodenal biopsies. Assessing
GFD adherence is certainly difficult in adults and it can be even more difficult in children. I see
the points related to Authors' clinical experience and the growing interest on GIPs. However,
GIPs can only identify traces of gluten ingested within 48-72 hours before the test and cannot
be entirely representative of the "whole" degree of adherence. I believe this is a relevant aspect
and I think this should be discussed among the limits of the study.
Please review this paper.
user
Title: Intestinal fatty acid binding protein is a disease biomarker in paediatric coeliac disease
and Crohn’s disease
Version: 3 Date: 22 Mar 2022
Reviewer's report:
Thank you for allowing me to review this revised version of the manuscript.
The Authors have carefully addressed the majority of the points raised by me and also by
reviewer 1.
I only still have a few concerns about the  methodology for assessing adherence to a GFD in this
pediatric cohort. I totally understand the aspect about follow-up duodenal biopsies. Assessing
GFD adherence is certainly difficult in adults and it can be even more difficult in children. I see
the points related to Authors' clinical experience and the growing interest on GIPs. However,
GIPs can only identify traces of gluten ingested within 48-72 hours before the test and cannot
be entirely representative of the "whole" degree of adherence. I believe this is a relevant aspect
and I think this should be discussed among the limits of the study.
assistant