Reviewer's report
Title:Safety and efficacy of the immunosuppressive agent 6-tioguanine in
murine model of acute colitis
Version: 1Date:12 October 2010
Reviewer: Yuji Naito
Reviewer's report:
In the present study, the authors investigate the safety and efficacy of
immunomodulators against DSS-induced colitis. However, they showed only the
disease activities and histological findings without any immunological or
inflammation data in spite of investigating the effect of immunomodulators. In
addition, the investigation of safety is a quite preliminary data.
The present form should be revised according to the following suggestion.
1) They should compare the serum concentration of 6TGNs between two drugs,
2) They should investigate the immunological parameters to understand the
properties of these drugs.
3) Analysis for safety is not enough.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Safety and efficacy of the immunosuppressive agent 6-tioguanine in
murine model of acute colitis
Version: 1Date:12 October 2010
Reviewer: Yuji Naito
Reviewer's report:
In the present study, the authors investigate the safety and efficacy of
immunomodulators against DSS-induced colitis. However, they showed only the
disease activities and histological findings without any immunological or
inflammation data in spite of investigating the effect of immunomodulators. In
addition, the investigation of safety is a quite preliminary data.
The present form should be revised according to the following suggestion.
1) They should compare the serum concentration of 6TGNs between two drugs,
2) They should investigate the immunological parameters to understand the
properties of these drugs.
3) Analysis for safety is not enough.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Safety and efficacy of the immunosuppressive agent 6-tioguanine in
murine model of acute colitis
Version: 1Date:12 October 2010
Reviewer: Yuji Naito
Reviewer's report:
In the present study, the authors investigate the safety and efficacy of
immunomodulators against DSS-induced colitis. However, they showed only the
disease activities and histological findings without any immunological or
inflammation data in spite of investigating the effect of immunomodulators. In
addition, the investigation of safety is a quite preliminary data.
The present form should be revised according to the following suggestion.
1) They should compare the serum concentration of 6TGNs between two drugs,
2) They should investigate the immunological parameters to understand the
properties of these drugs.
3) Analysis for safety is not enough.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant