Reviewer's report
Title:Leukocytosis and high hematocrit levels during abdominal attacks of
hereditary angioedema
Version: 10Date:17 April 2013
Reviewer: Efimia Papadopoulou
Reviewer's report:
Minor Essential Revisions
The authors have responded sufficiently well to my suggestions for their
manuscript entitled ''Leukocytosis and high hematocrit levels during abdominal
attacks of hereditary angioedema''.
The authors give further evidence for HAE diagnosis. They provide additional
necessary measurements in order to establish a complete HAE diagnosis.
C1-INH antigenic levels are determined in 10/14 patients (Table 1).
The authors corrected the interpretation error : the detection of low levels of C4 is
the key test for screening HAE patients.
The authors include in their methods the short description of method for
functional and antigenic C1-IHN levels determination.
Furthermore, the authors should provide clarification regarding the following:
1) Is the work a retrospective one?
2) It is mentioned in ''Methods'' that family and past histories of 14 patients were
collected from their medical records. Were recurrent angioedema attacks
reported in personal histories for all 14 patients (100%) ? The authors should
provide all the evidence needed for all patients to fullfil the criteria of HAE
diagnosis according Agostoni (Ref.8).
2) Anti -nuclear antibodies and immune complexes are included in the analysis.
The authors should comment on the findings (positive or negative) of the above
parametes in ''Results''.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Leukocytosis and high hematocrit levels during abdominal attacks of
hereditary angioedema
Version: 10Date:17 April 2013
Reviewer: Efimia Papadopoulou
Reviewer's report:
Minor Essential Revisions
The authors have responded sufficiently well to my suggestions for their
manuscript entitled ''Leukocytosis and high hematocrit levels during abdominal
attacks of hereditary angioedema''.
The authors give further evidence for HAE diagnosis. They provide additional
necessary measurements in order to establish a complete HAE diagnosis.
C1-INH antigenic levels are determined in 10/14 patients (Table 1).
The authors corrected the interpretation error : the detection of low levels of C4 is
the key test for screening HAE patients.
The authors include in their methods the short description of method for
functional and antigenic C1-IHN levels determination.
Furthermore, the authors should provide clarification regarding the following:
1) Is the work a retrospective one?
2) It is mentioned in ''Methods'' that family and past histories of 14 patients were
collected from their medical records. Were recurrent angioedema attacks
reported in personal histories for all 14 patients (100%) ? The authors should
provide all the evidence needed for all patients to fullfil the criteria of HAE
diagnosis according Agostoni (Ref.8).
2) Anti -nuclear antibodies and immune complexes are included in the analysis.
The authors should comment on the findings (positive or negative) of the above
parametes in ''Results''.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Leukocytosis and high hematocrit levels during abdominal attacks of
hereditary angioedema
Version: 10Date:17 April 2013
Reviewer: Efimia Papadopoulou
Reviewer's report:
Minor Essential Revisions
The authors have responded sufficiently well to my suggestions for their
manuscript entitled ''Leukocytosis and high hematocrit levels during abdominal
attacks of hereditary angioedema''.
The authors give further evidence for HAE diagnosis. They provide additional
necessary measurements in order to establish a complete HAE diagnosis.
C1-INH antigenic levels are determined in 10/14 patients (Table 1).
The authors corrected the interpretation error : the detection of low levels of C4 is
the key test for screening HAE patients.
The authors include in their methods the short description of method for
functional and antigenic C1-IHN levels determination.
Furthermore, the authors should provide clarification regarding the following:
1) Is the work a retrospective one?
2) It is mentioned in ''Methods'' that family and past histories of 14 patients were
collected from their medical records. Were recurrent angioedema attacks
reported in personal histories for all 14 patients (100%) ? The authors should
provide all the evidence needed for all patients to fullfil the criteria of HAE
diagnosis according Agostoni (Ref.8).
2) Anti -nuclear antibodies and immune complexes are included in the analysis.
The authors should comment on the findings (positive or negative) of the above
parametes in ''Results''.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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