Title: Preliminary Study on the Diagnostic Value of LEAP-2 and CK18 in Biopsy-Proven
MAFLD
Version: 2 Date: 22 Dec 2023
Reviewer's report:
The manuscript explores the role of different expression levels of CK18 M30/M65 and LEAP-2
in diagnosing MAFLD. Overall, the study is relevant and it has been designed properly, although
there are some major issues that must be regarded:
Introduction:
*Page 2 (lines 28-29) - I suggest including a brief description about NAFLD now being called
metabolic dysfunction–associated steatotic liver disease (MASLD) and its differences from
MAFLD.
*Page 3 (line 43) - I suggest replacing "which is not sensitive enough" for "despite of not being
sensitive enough" to eliminate ambiguity in this sentence.
Methods:
*Page 5 (line 93) - Monocyte (MONO) abbreviation, as well as basophils (BASO) and
eosinophils (EO) descriptions are missing from the methods section. They are reported
afterwards on page 7, line 123 and on the table. Uric acid shows different abbreviation on
the methods section and on the results section. Other abbreviations lack description or are
misspelled.
Title: Preliminary Study on the Diagnostic Value of LEAP-2 and CK18 in Biopsy-Proven
MAFLD
Version: 2 Date: 22 Dec 2023
Reviewer's report:
The manuscript explores the role of different expression levels of CK18 M30/M65 and LEAP-2
in diagnosing MAFLD. Overall, the study is relevant and it has been designed properly, although
there are some major issues that must be regarded:
Introduction:
*Page 2 (lines 28-29) - I suggest including a brief description about NAFLD now being called
metabolic dysfunction–associated steatotic liver disease (MASLD) and its differences from
MAFLD.
*Page 3 (line 43) - I suggest replacing "which is not sensitive enough" for "despite of not being
sensitive enough" to eliminate ambiguity in this sentence.
Methods:
*Page 5 (line 93) - Monocyte (MONO) abbreviation, as well as basophils (BASO) and
eosinophils (EO) descriptions are missing from the methods section. They are reported
afterwards on page 7, line 123 and on the table. Uric acid shows different abbreviation on
the methods section and on the results section. Other abbreviations lack description or are
misspelled.
Please review this paper.
user
Title: Preliminary Study on the Diagnostic Value of LEAP-2 and CK18 in Biopsy-Proven
MAFLD
Version: 2 Date: 22 Dec 2023
Reviewer's report:
The manuscript explores the role of different expression levels of CK18 M30/M65 and LEAP-2
in diagnosing MAFLD. Overall, the study is relevant and it has been designed properly, although
there are some major issues that must be regarded:
Introduction:
*Page 2 (lines 28-29) - I suggest including a brief description about NAFLD now being called
metabolic dysfunction–associated steatotic liver disease (MASLD) and its differences from
MAFLD.
*Page 3 (line 43) - I suggest replacing "which is not sensitive enough" for "despite of not being
sensitive enough" to eliminate ambiguity in this sentence.
Methods:
*Page 5 (line 93) - Monocyte (MONO) abbreviation, as well as basophils (BASO) and
eosinophils (EO) descriptions are missing from the methods section. They are reported
afterwards on page 7, line 123 and on the table. Uric acid shows different abbreviation on
the methods section and on the results section. Other abbreviations lack description or are
misspelled.
assistant