Title: Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in
children
Version: 4 Date: 15 Dec 2021
Reviewer:  Manal F Elshamaa
Reviewer's report:
Dear Authors
The manuscript entitled"Assessment of the diagnostic value of serum ceruloplasmin for
Wilson’s disease in children: is welcome
Add :The: to the title        the diagnostic
Some English editing is needed
The abstract should be summarized and be concise to the most significant results. Some results
mentioned here were not mentioned in the result section text.
Introduction
The Atp7b protein is a copper-transporting ATPase expressed predominantly in the liver and
to a lesser extent in most other tissues. Mutations in the ATP7B gene lead to Wilson disease, a
copper toxicity disorder characterized by a dramatic build-up of intracellular
hepatic copper with subsequent hepatic and neurological abnormalities.
A paragraph is needed to clarify this gene and the site of the mutation studied in this research.
Abbreviations all over the manuscript should be mentioned in an expanded form first then
abbreviated afterward.
Socha reference  should be numbered in the text correctly
Materials and methods
mention the criteria of the score used for the diagnosis of WD
Results
All results need to be well organized and well arranged for more easy understanding.
P-value should be written in the results section after each result respectively. few errors in results
are mentioned here than in tables please revise well.
Table 2 Add healthy controls results and compare between two groups and add P-Value in a
separate column
Table 4 Add WS patients and healthy controls results and compare among different groups and
Add P Values in a separate column
Table 1& Table 3 Add p-value in a separate column
Figure 2 needs to be more labeled and specified to each studied group.
Discussion
Paragraphs 1 &2 need to be transferred to the results section
No need to repeat results again in the discussion section
Title: Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in
children
Version: 4 Date: 15 Dec 2021
Reviewer:  Manal F Elshamaa
Reviewer's report:
Dear Authors
The manuscript entitled"Assessment of the diagnostic value of serum ceruloplasmin for
Wilson’s disease in children: is welcome
Add :The: to the title        the diagnostic
Some English editing is needed
The abstract should be summarized and be concise to the most significant results. Some results
mentioned here were not mentioned in the result section text.
Introduction
The Atp7b protein is a copper-transporting ATPase expressed predominantly in the liver and
to a lesser extent in most other tissues. Mutations in the ATP7B gene lead to Wilson disease, a
copper toxicity disorder characterized by a dramatic build-up of intracellular
hepatic copper with subsequent hepatic and neurological abnormalities.
A paragraph is needed to clarify this gene and the site of the mutation studied in this research.
Abbreviations all over the manuscript should be mentioned in an expanded form first then
abbreviated afterward.
Socha reference  should be numbered in the text correctly
Materials and methods
mention the criteria of the score used for the diagnosis of WD
Results
All results need to be well organized and well arranged for more easy understanding.
P-value should be written in the results section after each result respectively. few errors in results
are mentioned here than in tables please revise well.
Table 2 Add healthy controls results and compare between two groups and add P-Value in a
separate column
Table 4 Add WS patients and healthy controls results and compare among different groups and
Add P Values in a separate column
Table 1& Table 3 Add p-value in a separate column
Figure 2 needs to be more labeled and specified to each studied group.
Discussion
Paragraphs 1 &2 need to be transferred to the results section
No need to repeat results again in the discussion section
Please review this paper.
user
Title: Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in
children
Version: 4 Date: 15 Dec 2021
Reviewer:  Manal F Elshamaa
Reviewer's report:
Dear Authors
The manuscript entitled"Assessment of the diagnostic value of serum ceruloplasmin for
Wilson’s disease in children: is welcome
Add :The: to the title        the diagnostic
Some English editing is needed
The abstract should be summarized and be concise to the most significant results. Some results
mentioned here were not mentioned in the result section text.
Introduction
The Atp7b protein is a copper-transporting ATPase expressed predominantly in the liver and
to a lesser extent in most other tissues. Mutations in the ATP7B gene lead to Wilson disease, a
copper toxicity disorder characterized by a dramatic build-up of intracellular
hepatic copper with subsequent hepatic and neurological abnormalities.
A paragraph is needed to clarify this gene and the site of the mutation studied in this research.
Abbreviations all over the manuscript should be mentioned in an expanded form first then
abbreviated afterward.
Socha reference  should be numbered in the text correctly
Materials and methods
mention the criteria of the score used for the diagnosis of WD
Results
All results need to be well organized and well arranged for more easy understanding.
P-value should be written in the results section after each result respectively. few errors in results
are mentioned here than in tables please revise well.
Table 2 Add healthy controls results and compare between two groups and add P-Value in a
separate column
Table 4 Add WS patients and healthy controls results and compare among different groups and
Add P Values in a separate column
Table 1& Table 3 Add p-value in a separate column
Figure 2 needs to be more labeled and specified to each studied group.
Discussion
Paragraphs 1 &2 need to be transferred to the results section
No need to repeat results again in the discussion section
assistant