Reviewer's report
Title:A randomized, double-blind, placebo-controlled, multiple-dose
parallel-group clinical trial to assess the effects of teduglutide on gastric emptying
of liquids in healthy subjects
Version:3Date:21 November 2013
Reviewer: Bolette Hartmann
Reviewer's report:
The authors have revised the manuscript carefully and addressed the reviewers’
comments adequately. However, the conclusion (only the last sentence) still
needs revision.
Major comment.
I disagree that “it is unlikely that the main therapeutic effects of teduglutide,
enhanced fluid and nutrient absorption, are mediated through delay of gastric
emptying of fluids.”
Although, this study show no effect of teduglutide on gastric emptying in healthy
subjects, the effect in SBS patients remains to be investigated.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests' below.
Reviewer's report
Title:A randomized, double-blind, placebo-controlled, multiple-dose
parallel-group clinical trial to assess the effects of teduglutide on gastric emptying
of liquids in healthy subjects
Version:3Date:21 November 2013
Reviewer: Bolette Hartmann
Reviewer's report:
The authors have revised the manuscript carefully and addressed the reviewers’
comments adequately. However, the conclusion (only the last sentence) still
needs revision.
Major comment.
I disagree that “it is unlikely that the main therapeutic effects of teduglutide,
enhanced fluid and nutrient absorption, are mediated through delay of gastric
emptying of fluids.”
Although, this study show no effect of teduglutide on gastric emptying in healthy
subjects, the effect in SBS patients remains to be investigated.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests' below.
Please review this paper.
user
Reviewer's report
Title:A randomized, double-blind, placebo-controlled, multiple-dose
parallel-group clinical trial to assess the effects of teduglutide on gastric emptying
of liquids in healthy subjects
Version:3Date:21 November 2013
Reviewer: Bolette Hartmann
Reviewer's report:
The authors have revised the manuscript carefully and addressed the reviewers’
comments adequately. However, the conclusion (only the last sentence) still
needs revision.
Major comment.
I disagree that “it is unlikely that the main therapeutic effects of teduglutide,
enhanced fluid and nutrient absorption, are mediated through delay of gastric
emptying of fluids.”
Although, this study show no effect of teduglutide on gastric emptying in healthy
subjects, the effect in SBS patients remains to be investigated.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests' below.
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