Title: Aggregate index of systemic inflammation tied to increased fatty liver disease risk:
insights from NHANES data
Version: 3 Date: 04 May 2025
Reviewer:  Amira A. A. Othman
Reviewer's report:
The updated manuscript shows sincere and commendable effort in addressing the reviewer's
concerns. Including critical elements such as ICA-AKI criteria, renal biomarkers, and Doppler
results brings useful depth to the research. However, there is still a need for some critical
clarifications to strengthen the manuscript further. Specifically, we would like the authors to
clearly state the absence of follow-up after long periods and point-of-care volume measurements
(e.g., POCUS) as study limitations, and to elaborate a bit on the consideration of nephrotoxic
drug exposures. These revisions will not only help to enhance the scientific transparency of
the report but also guide future studies in this worthwhile area. We believe the manuscript is
nearly complete, and we look forward eagerly to seeing a version that fully incorporates these
considerate revisions.
Title: Aggregate index of systemic inflammation tied to increased fatty liver disease risk:
insights from NHANES data
Version: 3 Date: 04 May 2025
Reviewer:  Amira A. A. Othman
Reviewer's report:
The updated manuscript shows sincere and commendable effort in addressing the reviewer's
concerns. Including critical elements such as ICA-AKI criteria, renal biomarkers, and Doppler
results brings useful depth to the research. However, there is still a need for some critical
clarifications to strengthen the manuscript further. Specifically, we would like the authors to
clearly state the absence of follow-up after long periods and point-of-care volume measurements
(e.g., POCUS) as study limitations, and to elaborate a bit on the consideration of nephrotoxic
drug exposures. These revisions will not only help to enhance the scientific transparency of
the report but also guide future studies in this worthwhile area. We believe the manuscript is
nearly complete, and we look forward eagerly to seeing a version that fully incorporates these
considerate revisions.
Please review this paper.
user
Title: Aggregate index of systemic inflammation tied to increased fatty liver disease risk:
insights from NHANES data
Version: 3 Date: 04 May 2025
Reviewer:  Amira A. A. Othman
Reviewer's report:
The updated manuscript shows sincere and commendable effort in addressing the reviewer's
concerns. Including critical elements such as ICA-AKI criteria, renal biomarkers, and Doppler
results brings useful depth to the research. However, there is still a need for some critical
clarifications to strengthen the manuscript further. Specifically, we would like the authors to
clearly state the absence of follow-up after long periods and point-of-care volume measurements
(e.g., POCUS) as study limitations, and to elaborate a bit on the consideration of nephrotoxic
drug exposures. These revisions will not only help to enhance the scientific transparency of
the report but also guide future studies in this worthwhile area. We believe the manuscript is
nearly complete, and we look forward eagerly to seeing a version that fully incorporates these
considerate revisions.
assistant