Title: Early Acetaminophen Administration and Mortality Outcomes in Critically Ill Patients
with Cirrhosis: A Retrospective Analysis from the MIMIC-IV Database
Version: 0 Date: 25 Mar 2025
Reviewer's report:
I read with attention Fan et al's work. They suggest that early APAP use is associated with worse
prognosis in cirrhosis patients in ICU. The study is interesting with advanced methodology.
Some remarks can be nececassary nevertheless:
- APAP dose woud be interesting. Have you got these informations? Also, what are indications?
- Child-Pugh-Turcotte and MELD score are prognostic in cirrhosis, have you got data?
- In results, line 163, method description is unuseful.
- Line 248, the term primitive biliary cholangitis must replaced primitive biliary cirrhosis.
Title: Early Acetaminophen Administration and Mortality Outcomes in Critically Ill Patients
with Cirrhosis: A Retrospective Analysis from the MIMIC-IV Database
Version: 0 Date: 25 Mar 2025
Reviewer's report:
I read with attention Fan et al's work. They suggest that early APAP use is associated with worse
prognosis in cirrhosis patients in ICU. The study is interesting with advanced methodology.
Some remarks can be nececassary nevertheless:
- APAP dose woud be interesting. Have you got these informations? Also, what are indications?
- Child-Pugh-Turcotte and MELD score are prognostic in cirrhosis, have you got data?
- In results, line 163, method description is unuseful.
- Line 248, the term primitive biliary cholangitis must replaced primitive biliary cirrhosis.
Please review this paper.
user
Title: Early Acetaminophen Administration and Mortality Outcomes in Critically Ill Patients
with Cirrhosis: A Retrospective Analysis from the MIMIC-IV Database
Version: 0 Date: 25 Mar 2025
Reviewer's report:
I read with attention Fan et al's work. They suggest that early APAP use is associated with worse
prognosis in cirrhosis patients in ICU. The study is interesting with advanced methodology.
Some remarks can be nececassary nevertheless:
- APAP dose woud be interesting. Have you got these informations? Also, what are indications?
- Child-Pugh-Turcotte and MELD score are prognostic in cirrhosis, have you got data?
- In results, line 163, method description is unuseful.
- Line 248, the term primitive biliary cholangitis must replaced primitive biliary cirrhosis.
assistant