Reviewer's report
Title:Luminal lactate in acute pancreatitis - Validation and relation to disease
severity.
Version: 1Date:5 December 2011
Reviewer: Basil Ammori
Reviewer's report:
Major Compulsory Revisions
- The authors' hypothesis was that luminal lactate on admission predicts severity
of acute pancreatitis, yet their conclusion does not refer to this at all. That luminal
lactate did not predict severity needs to be stated. Moreover, the patients were
not classified into mild and severe attacks and no method of classification was
adopted. This shortcoming needs to be addressed.
- The authors overstate their conclusion "The association between rectal luminal
lactate and oxygen tension indicates that luminal lactate is a marker mucosal
anaerobiosis." In fact, that association was weak with an r2=0.3. This gives little
support to the conclusion statement. This needs to be discussed.
- The 'Primary and secondary end point parameters" should be replaced with
"Primary and secondary endpoints".
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Luminal lactate in acute pancreatitis - Validation and relation to disease
severity.
Version: 1Date:5 December 2011
Reviewer: Basil Ammori
Reviewer's report:
Major Compulsory Revisions
- The authors' hypothesis was that luminal lactate on admission predicts severity
of acute pancreatitis, yet their conclusion does not refer to this at all. That luminal
lactate did not predict severity needs to be stated. Moreover, the patients were
not classified into mild and severe attacks and no method of classification was
adopted. This shortcoming needs to be addressed.
- The authors overstate their conclusion "The association between rectal luminal
lactate and oxygen tension indicates that luminal lactate is a marker mucosal
anaerobiosis." In fact, that association was weak with an r2=0.3. This gives little
support to the conclusion statement. This needs to be discussed.
- The 'Primary and secondary end point parameters" should be replaced with
"Primary and secondary endpoints".
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
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Reviewer's report
Title:Luminal lactate in acute pancreatitis - Validation and relation to disease
severity.
Version: 1Date:5 December 2011
Reviewer: Basil Ammori
Reviewer's report:
Major Compulsory Revisions
- The authors' hypothesis was that luminal lactate on admission predicts severity
of acute pancreatitis, yet their conclusion does not refer to this at all. That luminal
lactate did not predict severity needs to be stated. Moreover, the patients were
not classified into mild and severe attacks and no method of classification was
adopted. This shortcoming needs to be addressed.
- The authors overstate their conclusion "The association between rectal luminal
lactate and oxygen tension indicates that luminal lactate is a marker mucosal
anaerobiosis." In fact, that association was weak with an r2=0.3. This gives little
support to the conclusion statement. This needs to be discussed.
- The 'Primary and secondary end point parameters" should be replaced with
"Primary and secondary endpoints".
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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