Title: Effect of Ramadan intermittent fasting on inflammatory markers, disease severity,
depression, and quality of life in patients with inflammatory bowel diseases: A prospective
cohort study
Version: 1 Date: 05 Mar 2022
Reviewer:  Moezalislam Ezzat Faris
Reviewer's report:
- I have been invited to review the original research article titled: Assessment of the effect of
Intermittent (Ramadan) fasting on inflammatory markers in patients with inflammatory bowel
diseases by Negm et al.
-- The article tackled an important topic, and tried to address and bridge a gap in knowledge
with regard to the impact of the observance of Ramadan IF on patients diagnosed with IBD
(UC and CD). Though the paper is important from a clinical point of view and will help the
clinicians to take the right decision about the practice of RIF by adult Muslim patients, however,
the manuscript entailed a list of pitfalls and comments that should be clearly addressed to be
eligible for publications.
-The manuscript needs a massive linguistic revision by a native English proofreader.
-There are many inconsistencies in the scientific writing. Need to be clearly addressed.
-Don’t use the disease as an adjective for the patients. Use “patients diagnosed with IBD” instead
of “IBD patients” throughout the manuscript.
-Considering the observational nature of the study, don’t use the “causality” phrases such as
lead, led, cause, and others. Use always: RIF is/was associated with the outcome.
-It cannot be ascertained that the observance of RIF has a deleterious effect on the patients with
IBD, considering that the fCal and CRP were not changed significantly. Better to use diluted
terms “associated with adverse effects. Mention the specific measure adversely affected after
RIF, not the general disease condition.
-Adopt fixed acronyms throughout the manuscript: (IBD) ulcerative colitis (UC) and Crohn’s
disease (CD), intermittent fasting (IF), Ramadan IF (RIF)
- Detailed comments, edits, suggestions are included within the text of the attached file
https://www.dropbox.com/scl/fi/l3rvt5pqtndw94g0zr3a9/Effect-of-Intermittent-fasting-on-
patients-with-IBD-332022.docx?dl=0&rlkey=20igtoh4jgwnag7haeibu1h7c
Title: Effect of Ramadan intermittent fasting on inflammatory markers, disease severity,
depression, and quality of life in patients with inflammatory bowel diseases: A prospective
cohort study
Version: 1 Date: 05 Mar 2022
Reviewer:  Moezalislam Ezzat Faris
Reviewer's report:
- I have been invited to review the original research article titled: Assessment of the effect of
Intermittent (Ramadan) fasting on inflammatory markers in patients with inflammatory bowel
diseases by Negm et al.
-- The article tackled an important topic, and tried to address and bridge a gap in knowledge
with regard to the impact of the observance of Ramadan IF on patients diagnosed with IBD
(UC and CD). Though the paper is important from a clinical point of view and will help the
clinicians to take the right decision about the practice of RIF by adult Muslim patients, however,
the manuscript entailed a list of pitfalls and comments that should be clearly addressed to be
eligible for publications.
-The manuscript needs a massive linguistic revision by a native English proofreader.
-There are many inconsistencies in the scientific writing. Need to be clearly addressed.
-Don’t use the disease as an adjective for the patients. Use “patients diagnosed with IBD” instead
of “IBD patients” throughout the manuscript.
-Considering the observational nature of the study, don’t use the “causality” phrases such as
lead, led, cause, and others. Use always: RIF is/was associated with the outcome.
-It cannot be ascertained that the observance of RIF has a deleterious effect on the patients with
IBD, considering that the fCal and CRP were not changed significantly. Better to use diluted
terms “associated with adverse effects. Mention the specific measure adversely affected after
RIF, not the general disease condition.
-Adopt fixed acronyms throughout the manuscript: (IBD) ulcerative colitis (UC) and Crohn’s
disease (CD), intermittent fasting (IF), Ramadan IF (RIF)
- Detailed comments, edits, suggestions are included within the text of the attached file
https://www.dropbox.com/scl/fi/l3rvt5pqtndw94g0zr3a9/Effect-of-Intermittent-fasting-on-
patients-with-IBD-332022.docx?dl=0&rlkey=20igtoh4jgwnag7haeibu1h7c
Please review this paper.
user
Title: Effect of Ramadan intermittent fasting on inflammatory markers, disease severity,
depression, and quality of life in patients with inflammatory bowel diseases: A prospective
cohort study
Version: 1 Date: 05 Mar 2022
Reviewer:  Moezalislam Ezzat Faris
Reviewer's report:
- I have been invited to review the original research article titled: Assessment of the effect of
Intermittent (Ramadan) fasting on inflammatory markers in patients with inflammatory bowel
diseases by Negm et al.
-- The article tackled an important topic, and tried to address and bridge a gap in knowledge
with regard to the impact of the observance of Ramadan IF on patients diagnosed with IBD
(UC and CD). Though the paper is important from a clinical point of view and will help the
clinicians to take the right decision about the practice of RIF by adult Muslim patients, however,
the manuscript entailed a list of pitfalls and comments that should be clearly addressed to be
eligible for publications.
-The manuscript needs a massive linguistic revision by a native English proofreader.
-There are many inconsistencies in the scientific writing. Need to be clearly addressed.
-Don’t use the disease as an adjective for the patients. Use “patients diagnosed with IBD” instead
of “IBD patients” throughout the manuscript.
-Considering the observational nature of the study, don’t use the “causality” phrases such as
lead, led, cause, and others. Use always: RIF is/was associated with the outcome.
-It cannot be ascertained that the observance of RIF has a deleterious effect on the patients with
IBD, considering that the fCal and CRP were not changed significantly. Better to use diluted
terms “associated with adverse effects. Mention the specific measure adversely affected after
RIF, not the general disease condition.
-Adopt fixed acronyms throughout the manuscript: (IBD) ulcerative colitis (UC) and Crohn’s
disease (CD), intermittent fasting (IF), Ramadan IF (RIF)
- Detailed comments, edits, suggestions are included within the text of the attached file
https://www.dropbox.com/scl/fi/l3rvt5pqtndw94g0zr3a9/Effect-of-Intermittent-fasting-on-
patients-with-IBD-332022.docx?dl=0&rlkey=20igtoh4jgwnag7haeibu1h7c
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