Reviewer's report
Title:Gluten sensitivity enteropathy and recurrent aphthous stomatitis
Version: 3Date:26 November 2008
Reviewer: Julio C Bai
Reviewer's report:
The manuscript by Ramin Shakeri et al antitled: “Gluten sensitivity enteropathy
and recurrent aphthous stomatitis” is a very interesting piece of epidemiological
research evidencing an almost three folds greater prevalence of CD among
patients with oral aphthoid ulcerations than in the general population. The study
also confirms that the CD specific treatment solves the RAS problem.
The question of the authors is adequate and the methods employed are the
currently used. Results should be considered with the limitations reported below
The authors define cases as gluten sensitive enteropathy in place of CD mainly
due to the high prevalence of minor mucosal damage. Definition of enteropathy
according to Marsh´s criteria should be more explicit considering the prevalence
of minor changes among cases identified.
It is interesting consider that patients with minor mucosal damage may have a
lower prevalence of positive serology tests; therefore, the authors should be
more cautious in estimating the prevalence of GSE since that other RAS cases
could have similar changes but not detected by the serologic/histologic algorithm
employed.
The results section looks very short.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interests
Reviewer's report
Title:Gluten sensitivity enteropathy and recurrent aphthous stomatitis
Version: 3Date:26 November 2008
Reviewer: Julio C Bai
Reviewer's report:
The manuscript by Ramin Shakeri et al antitled: “Gluten sensitivity enteropathy
and recurrent aphthous stomatitis” is a very interesting piece of epidemiological
research evidencing an almost three folds greater prevalence of CD among
patients with oral aphthoid ulcerations than in the general population. The study
also confirms that the CD specific treatment solves the RAS problem.
The question of the authors is adequate and the methods employed are the
currently used. Results should be considered with the limitations reported below
The authors define cases as gluten sensitive enteropathy in place of CD mainly
due to the high prevalence of minor mucosal damage. Definition of enteropathy
according to Marsh´s criteria should be more explicit considering the prevalence
of minor changes among cases identified.
It is interesting consider that patients with minor mucosal damage may have a
lower prevalence of positive serology tests; therefore, the authors should be
more cautious in estimating the prevalence of GSE since that other RAS cases
could have similar changes but not detected by the serologic/histologic algorithm
employed.
The results section looks very short.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interests
Please review this paper.
user
Reviewer's report
Title:Gluten sensitivity enteropathy and recurrent aphthous stomatitis
Version: 3Date:26 November 2008
Reviewer: Julio C Bai
Reviewer's report:
The manuscript by Ramin Shakeri et al antitled: “Gluten sensitivity enteropathy
and recurrent aphthous stomatitis” is a very interesting piece of epidemiological
research evidencing an almost three folds greater prevalence of CD among
patients with oral aphthoid ulcerations than in the general population. The study
also confirms that the CD specific treatment solves the RAS problem.
The question of the authors is adequate and the methods employed are the
currently used. Results should be considered with the limitations reported below
The authors define cases as gluten sensitive enteropathy in place of CD mainly
due to the high prevalence of minor mucosal damage. Definition of enteropathy
according to Marsh´s criteria should be more explicit considering the prevalence
of minor changes among cases identified.
It is interesting consider that patients with minor mucosal damage may have a
lower prevalence of positive serology tests; therefore, the authors should be
more cautious in estimating the prevalence of GSE since that other RAS cases
could have similar changes but not detected by the serologic/histologic algorithm
employed.
The results section looks very short.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interests
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