Title: Association between serum iron status and the risk of colorectal cancer in US adults: a
cross-sectional analysis of NHANES 2001–2020
Version: 2 Date: 31 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
It is worth noting that although iron deficiency anemia is related with high possibility to identify
advance neoplasia or advance adenomas iron deficiency without anemia is not  Methods Authors
should define the time point of iron deficiency measurement Moreover it should be defined if
more than one measurement was available and if Hb was measured as well  Statistics ANOVA
should be used for parameters with more than two subgroups Results analysis of iron deficiency
interconnection to colorectal neoplasia should be separately in patients with and without anemia
Title: Association between serum iron status and the risk of colorectal cancer in US adults: a
cross-sectional analysis of NHANES 2001–2020
Version: 2 Date: 31 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
It is worth noting that although iron deficiency anemia is related with high possibility to identify
advance neoplasia or advance adenomas iron deficiency without anemia is not  Methods Authors
should define the time point of iron deficiency measurement Moreover it should be defined if
more than one measurement was available and if Hb was measured as well  Statistics ANOVA
should be used for parameters with more than two subgroups Results analysis of iron deficiency
interconnection to colorectal neoplasia should be separately in patients with and without anemia
Please review this paper.
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Title: Association between serum iron status and the risk of colorectal cancer in US adults: a
cross-sectional analysis of NHANES 2001–2020
Version: 2 Date: 31 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
It is worth noting that although iron deficiency anemia is related with high possibility to identify
advance neoplasia or advance adenomas iron deficiency without anemia is not  Methods Authors
should define the time point of iron deficiency measurement Moreover it should be defined if
more than one measurement was available and if Hb was measured as well  Statistics ANOVA
should be used for parameters with more than two subgroups Results analysis of iron deficiency
interconnection to colorectal neoplasia should be separately in patients with and without anemia
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