Title: Long-Term Outcomes of S-1 and Oxaliplatin Neoadjuvant Chemotherapy with Total
Mesorectal Excision and Lateral Lymph Node Dissection for Rectal Cancer
Version: 3 Date: 13 Jun 2024
Reviewer's report:
"Phase II study. 52 patients. Aim to evaluate the long-term outcomes of S-1 and oxaliplatin with
total mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiation
for rectal cancer.
"
Thanks to the authors for submitting their work to BMC gastroenterology. I would consider it
for publication after major revisions.
1. Despite of general adequate grammar, it is advisible to make revisions of the manuscript'
structure and get it revised by a native english speaker in order to assure appropriate meaning
of sentences as well as readability.
2. Introduction: I suggest to use standard nomenclature. Total mesorectal excision instead of
total mesenteric excision. Central lymph node dissection is implied in the definition of TME.
3. Methods seccion: 58 patients included in the first work, 52 in the latter. Are the included
patients from a single institution?
4. Results:
1.This section is improvable by adding appropriate statistical information such as HR, CI and
p values. E.g. Rephrase the sentence "the risk factors for local recurrence were mucinous
carcinoma not adenocarcinoma" stating it objectively.
2.What does mean "ineligibility for R0 resection"?
3. In table 2 "resection margin" is the same as Circumferencial Resection Margin? or is it what
you describe as "inegibility for R0"?
4.Tables/figures:
*I suggest to use a more specific or descriptive tittle for tables. E.g table 3, prosgnostic factors
for what? OVERALL SURVIVAL?.
*Also, use a footnote to the table/figures describing abbreviations.
*In the figures, include the statistical method used. Is it a Kapplan-Meier as stated in methods?
if so, the number at risk is missing.
Title: Long-Term Outcomes of S-1 and Oxaliplatin Neoadjuvant Chemotherapy with Total
Mesorectal Excision and Lateral Lymph Node Dissection for Rectal Cancer
Version: 3 Date: 13 Jun 2024
Reviewer's report:
"Phase II study. 52 patients. Aim to evaluate the long-term outcomes of S-1 and oxaliplatin with
total mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiation
for rectal cancer.
"
Thanks to the authors for submitting their work to BMC gastroenterology. I would consider it
for publication after major revisions.
1. Despite of general adequate grammar, it is advisible to make revisions of the manuscript'
structure and get it revised by a native english speaker in order to assure appropriate meaning
of sentences as well as readability.
2. Introduction: I suggest to use standard nomenclature. Total mesorectal excision instead of
total mesenteric excision. Central lymph node dissection is implied in the definition of TME.
3. Methods seccion: 58 patients included in the first work, 52 in the latter. Are the included
patients from a single institution?
4. Results:
1.This section is improvable by adding appropriate statistical information such as HR, CI and
p values. E.g. Rephrase the sentence "the risk factors for local recurrence were mucinous
carcinoma not adenocarcinoma" stating it objectively.
2.What does mean "ineligibility for R0 resection"?
3. In table 2 "resection margin" is the same as Circumferencial Resection Margin? or is it what
you describe as "inegibility for R0"?
4.Tables/figures:
*I suggest to use a more specific or descriptive tittle for tables. E.g table 3, prosgnostic factors
for what? OVERALL SURVIVAL?.
*Also, use a footnote to the table/figures describing abbreviations.
*In the figures, include the statistical method used. Is it a Kapplan-Meier as stated in methods?
if so, the number at risk is missing.
Please review this paper.
user
Title: Long-Term Outcomes of S-1 and Oxaliplatin Neoadjuvant Chemotherapy with Total
Mesorectal Excision and Lateral Lymph Node Dissection for Rectal Cancer
Version: 3 Date: 13 Jun 2024
Reviewer's report:
"Phase II study. 52 patients. Aim to evaluate the long-term outcomes of S-1 and oxaliplatin with
total mesorectal excision (TME) and lateral lymph node dissection (LLND) without radiation
for rectal cancer.
"
Thanks to the authors for submitting their work to BMC gastroenterology. I would consider it
for publication after major revisions.
1. Despite of general adequate grammar, it is advisible to make revisions of the manuscript'
structure and get it revised by a native english speaker in order to assure appropriate meaning
of sentences as well as readability.
2. Introduction: I suggest to use standard nomenclature. Total mesorectal excision instead of
total mesenteric excision. Central lymph node dissection is implied in the definition of TME.
3. Methods seccion: 58 patients included in the first work, 52 in the latter. Are the included
patients from a single institution?
4. Results:
1.This section is improvable by adding appropriate statistical information such as HR, CI and
p values. E.g. Rephrase the sentence "the risk factors for local recurrence were mucinous
carcinoma not adenocarcinoma" stating it objectively.
2.What does mean "ineligibility for R0 resection"?
3. In table 2 "resection margin" is the same as Circumferencial Resection Margin? or is it what
you describe as "inegibility for R0"?
4.Tables/figures:
*I suggest to use a more specific or descriptive tittle for tables. E.g table 3, prosgnostic factors
for what? OVERALL SURVIVAL?.
*Also, use a footnote to the table/figures describing abbreviations.
*In the figures, include the statistical method used. Is it a Kapplan-Meier as stated in methods?
if so, the number at risk is missing.
assistant