Reviewer ’s report  
 
Title: Narrow -Band Imaging and High -Definition Wh ite-Light Endoscopy in patients with 
Serrated Lesions not fulfilling criteria for Serrated Polyposis Sy ndrome: A randomized controlled 
trial with tandem colonoscopy  
 
Version: 0 Date: 29 Apr 2019  
 
Reviewer: Vipin Gupta  
 
Reviewer's report:  
 
I congratulate authors for their efforts to answer very important question. Non -significant rates are 
not surprising but trend towar ds higher detection rates was expected with NBI .There are few 
minor points which needs to be discussed.  
 
1) Shall authors be in position to discuss family history for SSP .Were there any first degree 
relatives of SSP patients in study? As it would implicat ions on their final diagnosis.  
 
2) Authors have recommended reassessment colonoscopy at 1 year. I think data is not strong 
enough to make this recommendation  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in yo ur comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an additional 
statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in  the manuscript:  
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content of 
the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' below. 
If your reply is yes to any, please give details below.  
 
I declare that i have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' responses. 
I agree for my report to be made available under an Open Access Creative Commons CC-BY 
license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do 
not wish to be included in my named report can be included as confidential comments to the 
editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Narrow -Band Imaging and High -Definition Wh ite-Light Endoscopy in patients with 
Serrated Lesions not fulfilling criteria for Serrated Polyposis Sy ndrome: A randomized controlled 
trial with tandem colonoscopy  
 
Version: 0 Date: 29 Apr 2019  
 
Reviewer: Vipin Gupta  
 
Reviewer's report:  
 
I congratulate authors for their efforts to answer very important question. Non -significant rates are 
not surprising but trend towar ds higher detection rates was expected with NBI .There are few 
minor points which needs to be discussed.  
 
1) Shall authors be in position to discuss family history for SSP .Were there any first degree 
relatives of SSP patients in study? As it would implicat ions on their final diagnosis.  
 
2) Authors have recommended reassessment colonoscopy at 1 year. I think data is not strong 
enough to make this recommendation  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in yo ur comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an additional 
statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in  the manuscript:  
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content of 
the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' below. 
If your reply is yes to any, please give details below.  
 
I declare that i have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' responses. 
I agree for my report to be made available under an Open Access Creative Commons CC-BY 
license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do 
not wish to be included in my named report can be included as confidential comments to the 
editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Narrow -Band Imaging and High -Definition Wh ite-Light Endoscopy in patients with 
Serrated Lesions not fulfilling criteria for Serrated Polyposis Sy ndrome: A randomized controlled 
trial with tandem colonoscopy  
 
Version: 0 Date: 29 Apr 2019  
 
Reviewer: Vipin Gupta  
 
Reviewer's report:  
 
I congratulate authors for their efforts to answer very important question. Non -significant rates are 
not surprising but trend towar ds higher detection rates was expected with NBI .There are few 
minor points which needs to be discussed.  
 
1) Shall authors be in position to discuss family history for SSP .Were there any first degree 
relatives of SSP patients in study? As it would implicat ions on their final diagnosis.  
 
2) Authors have recommended reassessment colonoscopy at 1 year. I think data is not strong 
enough to make this recommendation  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in yo ur comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an additional 
statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in  the manuscript:  
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content of 
the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' below. 
If your reply is yes to any, please give details below.  
 
I declare that i have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' responses. 
I agree for my report to be made available under an Open Access Creative Commons CC-BY 
license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do 
not wish to be included in my named report can be included as confidential comments to the 
editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant