Title: Low thyroid function is associated with an increased risk of advanced fibrosis in patients
with metabolic dysfunction-associated fatty liver disease
Version: 1 Date: 10 Oct 2022
Reviewer:  Norberto C. Chávez-tapia
Reviewer's report:
I've read your interesting manuscript and some minor  comments are below:
Results
Line 225
Logistic regression was adjusted only for age and sex.
Do you consider that further adjustment for known pro-fibrotic factors such as, viral hepatitis,
Diabetes Mellitus or obesity could impact the results? Why was this not included?
Discussion
Line 265-266
Our findings indicate that patients with FLD should maintain their TSH levels at a strict-normal
level to reduce the risk of hepatic fibrosis.
Is it really possible to make that conclusion based on the findings? Can the analysis establish
a causal relationship?
Line 278
Limitations should include that NAFLD was by ultrasound and a selection bias for the patients
that underwent thyroid testing.
Tables
In the Table 1, is it necessary to divide the information according to the year?
Title: Low thyroid function is associated with an increased risk of advanced fibrosis in patients
with metabolic dysfunction-associated fatty liver disease
Version: 1 Date: 10 Oct 2022
Reviewer:  Norberto C. Chávez-tapia
Reviewer's report:
I've read your interesting manuscript and some minor  comments are below:
Results
Line 225
Logistic regression was adjusted only for age and sex.
Do you consider that further adjustment for known pro-fibrotic factors such as, viral hepatitis,
Diabetes Mellitus or obesity could impact the results? Why was this not included?
Discussion
Line 265-266
Our findings indicate that patients with FLD should maintain their TSH levels at a strict-normal
level to reduce the risk of hepatic fibrosis.
Is it really possible to make that conclusion based on the findings? Can the analysis establish
a causal relationship?
Line 278
Limitations should include that NAFLD was by ultrasound and a selection bias for the patients
that underwent thyroid testing.
Tables
In the Table 1, is it necessary to divide the information according to the year?
Please review this paper.
user
Title: Low thyroid function is associated with an increased risk of advanced fibrosis in patients
with metabolic dysfunction-associated fatty liver disease
Version: 1 Date: 10 Oct 2022
Reviewer:  Norberto C. Chávez-tapia
Reviewer's report:
I've read your interesting manuscript and some minor  comments are below:
Results
Line 225
Logistic regression was adjusted only for age and sex.
Do you consider that further adjustment for known pro-fibrotic factors such as, viral hepatitis,
Diabetes Mellitus or obesity could impact the results? Why was this not included?
Discussion
Line 265-266
Our findings indicate that patients with FLD should maintain their TSH levels at a strict-normal
level to reduce the risk of hepatic fibrosis.
Is it really possible to make that conclusion based on the findings? Can the analysis establish
a causal relationship?
Line 278
Limitations should include that NAFLD was by ultrasound and a selection bias for the patients
that underwent thyroid testing.
Tables
In the Table 1, is it necessary to divide the information according to the year?
assistant