Title: Accessory hepatic vein recanalization for Budd-Chiari syndrome: a systematic review
and meta-analysis
Version: 2 Date: 27 Mar 2023
Reviewer's report:
Thank you for inviting me to review this article.
The authors have neatly summarised the data related to AHV recanalization in this patient group
of 377 patients from 12 retrospective studies.  Additionally they have been able to compare
outcomes to direct HV recanalization in some studies.  The overall outcomes as published are
acceptable and this may offer an alternative therapy for BCS.
However, the demographics give information about the type of BCS obstruction, but do not give
any additional details about aetiology or presence of co-morbidity.  This would be useful in
assessing the overall survival data, which seems to be good.
The outcome measures focus on technical success and 1/5 year mortality.  It would be useful
to see some additional clinical data (such as resolution of ascites or  requirement for liver
transplant).
The manuscript describes the technical success of this procedure, which may have a role in the
management of BCS.  However, it would be useful to correlate this with some information about
the underlying aetiology of BCS and the clinical data (such as resolution of ascites/LT) prior to
final publication. This would allow the data to be more applicable to 'real world patient decision
making'.
Manuscript suggested edits:
Abstract Results, Page 2: should "relative to HC recanalazation" read "relative to HV
recanalazation"?
Title: Accessory hepatic vein recanalization for Budd-Chiari syndrome: a systematic review
and meta-analysis
Version: 2 Date: 27 Mar 2023
Reviewer's report:
Thank you for inviting me to review this article.
The authors have neatly summarised the data related to AHV recanalization in this patient group
of 377 patients from 12 retrospective studies.  Additionally they have been able to compare
outcomes to direct HV recanalization in some studies.  The overall outcomes as published are
acceptable and this may offer an alternative therapy for BCS.
However, the demographics give information about the type of BCS obstruction, but do not give
any additional details about aetiology or presence of co-morbidity.  This would be useful in
assessing the overall survival data, which seems to be good.
The outcome measures focus on technical success and 1/5 year mortality.  It would be useful
to see some additional clinical data (such as resolution of ascites or  requirement for liver
transplant).
The manuscript describes the technical success of this procedure, which may have a role in the
management of BCS.  However, it would be useful to correlate this with some information about
the underlying aetiology of BCS and the clinical data (such as resolution of ascites/LT) prior to
final publication. This would allow the data to be more applicable to 'real world patient decision
making'.
Manuscript suggested edits:
Abstract Results, Page 2: should "relative to HC recanalazation" read "relative to HV
recanalazation"?
Please review this paper.
user
Title: Accessory hepatic vein recanalization for Budd-Chiari syndrome: a systematic review
and meta-analysis
Version: 2 Date: 27 Mar 2023
Reviewer's report:
Thank you for inviting me to review this article.
The authors have neatly summarised the data related to AHV recanalization in this patient group
of 377 patients from 12 retrospective studies.  Additionally they have been able to compare
outcomes to direct HV recanalization in some studies.  The overall outcomes as published are
acceptable and this may offer an alternative therapy for BCS.
However, the demographics give information about the type of BCS obstruction, but do not give
any additional details about aetiology or presence of co-morbidity.  This would be useful in
assessing the overall survival data, which seems to be good.
The outcome measures focus on technical success and 1/5 year mortality.  It would be useful
to see some additional clinical data (such as resolution of ascites or  requirement for liver
transplant).
The manuscript describes the technical success of this procedure, which may have a role in the
management of BCS.  However, it would be useful to correlate this with some information about
the underlying aetiology of BCS and the clinical data (such as resolution of ascites/LT) prior to
final publication. This would allow the data to be more applicable to 'real world patient decision
making'.
Manuscript suggested edits:
Abstract Results, Page 2: should "relative to HC recanalazation" read "relative to HV
recanalazation"?
assistant