Title: Feasibility and repeatability of ultrasound-guided surface electroenterography to measure
colonic slow wave motility in healthy adults
Version: 1 Date: 18 Dec 2023
Reviewer's report:
In this study the authors have conducted ultrasound-guided electroenterography measurements
to measure colonic slow-wave muscle activity within 10 healthy adults. This study is within the
scope of the journal and the manuscript is well written. However it needs several clarifications/
changes before further assessment.
1) The novelty of this study lies in the use of ultrasound to guide electrode placement. But details
on this methodology are lacking i.e the single Figure 1 does not accurately show the link between
ultrasound and electrode placement.
2) One of the major limitations of the current methodology is the fact that the stomach's electrical
activity was not taken into account during the data processing, and this is justified by: "However,
it is not plausible that all measured activity originated in the stomach, because the largest
relative postprandial motility increase was not observed in the middle colon, which included
the electrodes closest to the stomach. " This statement is contradictory to that in Lines 185-176:
"Nevertheless, note that the median postprandial MPD is nearly twice as high as in the middle
colon compared to the proximal and distal colon."
There needs to be more justification as to why the stomach's electrical activity is not being
captured by the current data analysis.
Title: Feasibility and repeatability of ultrasound-guided surface electroenterography to measure
colonic slow wave motility in healthy adults
Version: 1 Date: 18 Dec 2023
Reviewer's report:
In this study the authors have conducted ultrasound-guided electroenterography measurements
to measure colonic slow-wave muscle activity within 10 healthy adults. This study is within the
scope of the journal and the manuscript is well written. However it needs several clarifications/
changes before further assessment.
1) The novelty of this study lies in the use of ultrasound to guide electrode placement. But details
on this methodology are lacking i.e the single Figure 1 does not accurately show the link between
ultrasound and electrode placement.
2) One of the major limitations of the current methodology is the fact that the stomach's electrical
activity was not taken into account during the data processing, and this is justified by: "However,
it is not plausible that all measured activity originated in the stomach, because the largest
relative postprandial motility increase was not observed in the middle colon, which included
the electrodes closest to the stomach. " This statement is contradictory to that in Lines 185-176:
"Nevertheless, note that the median postprandial MPD is nearly twice as high as in the middle
colon compared to the proximal and distal colon."
There needs to be more justification as to why the stomach's electrical activity is not being
captured by the current data analysis.
Please review this paper.
user
Title: Feasibility and repeatability of ultrasound-guided surface electroenterography to measure
colonic slow wave motility in healthy adults
Version: 1 Date: 18 Dec 2023
Reviewer's report:
In this study the authors have conducted ultrasound-guided electroenterography measurements
to measure colonic slow-wave muscle activity within 10 healthy adults. This study is within the
scope of the journal and the manuscript is well written. However it needs several clarifications/
changes before further assessment.
1) The novelty of this study lies in the use of ultrasound to guide electrode placement. But details
on this methodology are lacking i.e the single Figure 1 does not accurately show the link between
ultrasound and electrode placement.
2) One of the major limitations of the current methodology is the fact that the stomach's electrical
activity was not taken into account during the data processing, and this is justified by: "However,
it is not plausible that all measured activity originated in the stomach, because the largest
relative postprandial motility increase was not observed in the middle colon, which included
the electrodes closest to the stomach. " This statement is contradictory to that in Lines 185-176:
"Nevertheless, note that the median postprandial MPD is nearly twice as high as in the middle
colon compared to the proximal and distal colon."
There needs to be more justification as to why the stomach's electrical activity is not being
captured by the current data analysis.
assistant