Title: A nomogram based on CT texture features to predict the response of patients with
advanced pancreatic cancer treated with chemotherapy
Version: 1 Date: 24 Mar 2023
Reviewer's report:
Very interesting study. I have some methodlogical comments:
1) Validation cohort is too small. I would suggest to apply an internal validation approach
through bootstrapping. If not feasible, the authors should comment at least among the limitations
and they should cite some relevant papers on this approach (cite PMID: 27005802 and  PMID:
35451041)
2) The authors should specify in the title that a nomogram was used.
3) Why they used RECIST criteria and not mRECIST or other similar criteria?
4) The authors should briefly comment that also other methods for diagnosis of pancreatic
cancers are effective such as EUS (cite the recent meta-analysis PMID: 29026598 )
Title: A nomogram based on CT texture features to predict the response of patients with
advanced pancreatic cancer treated with chemotherapy
Version: 1 Date: 24 Mar 2023
Reviewer's report:
Very interesting study. I have some methodlogical comments:
1) Validation cohort is too small. I would suggest to apply an internal validation approach
through bootstrapping. If not feasible, the authors should comment at least among the limitations
and they should cite some relevant papers on this approach (cite PMID: 27005802 and  PMID:
35451041)
2) The authors should specify in the title that a nomogram was used.
3) Why they used RECIST criteria and not mRECIST or other similar criteria?
4) The authors should briefly comment that also other methods for diagnosis of pancreatic
cancers are effective such as EUS (cite the recent meta-analysis PMID: 29026598 )
Please review this paper.
user
Title: A nomogram based on CT texture features to predict the response of patients with
advanced pancreatic cancer treated with chemotherapy
Version: 1 Date: 24 Mar 2023
Reviewer's report:
Very interesting study. I have some methodlogical comments:
1) Validation cohort is too small. I would suggest to apply an internal validation approach
through bootstrapping. If not feasible, the authors should comment at least among the limitations
and they should cite some relevant papers on this approach (cite PMID: 27005802 and  PMID:
35451041)
2) The authors should specify in the title that a nomogram was used.
3) Why they used RECIST criteria and not mRECIST or other similar criteria?
4) The authors should briefly comment that also other methods for diagnosis of pancreatic
cancers are effective such as EUS (cite the recent meta-analysis PMID: 29026598 )
assistant