Title: ARID1A Deficiency Promotes Progression and Potentiates Therapeutic Antitumour
Immunity in Hepatitis B virus-related Hepatocellular Carcinoma
Version: 3 Date: 19 Jun 2023
Reviewer's report:
Xing et al used bioinformatics and basic experiments to reveal that ARID1A deficiency was
correlated with more active immune signatures and higher expression of immune checkpoints
in HBV-HCC. Meantime, ARID1A Deficiency Promotes Progression of HCC. This manuscript
has the following issues.
1, The results of colony formation in Figure 2F are not significant, please repeat these
experiments.
2, The Statistical charts lack Horizontal braces under asterisk.
3, Please make Statistical charts about the relationship between ARID1A and immune signatures
in Figure 4.
4, Please discuss the reasons about Inconsistent results in different cell lines in Figure 5b and c.
Title: ARID1A Deficiency Promotes Progression and Potentiates Therapeutic Antitumour
Immunity in Hepatitis B virus-related Hepatocellular Carcinoma
Version: 3 Date: 19 Jun 2023
Reviewer's report:
Xing et al used bioinformatics and basic experiments to reveal that ARID1A deficiency was
correlated with more active immune signatures and higher expression of immune checkpoints
in HBV-HCC. Meantime, ARID1A Deficiency Promotes Progression of HCC. This manuscript
has the following issues.
1, The results of colony formation in Figure 2F are not significant, please repeat these
experiments.
2, The Statistical charts lack Horizontal braces under asterisk.
3, Please make Statistical charts about the relationship between ARID1A and immune signatures
in Figure 4.
4, Please discuss the reasons about Inconsistent results in different cell lines in Figure 5b and c.
Please review this paper.
user
Title: ARID1A Deficiency Promotes Progression and Potentiates Therapeutic Antitumour
Immunity in Hepatitis B virus-related Hepatocellular Carcinoma
Version: 3 Date: 19 Jun 2023
Reviewer's report:
Xing et al used bioinformatics and basic experiments to reveal that ARID1A deficiency was
correlated with more active immune signatures and higher expression of immune checkpoints
in HBV-HCC. Meantime, ARID1A Deficiency Promotes Progression of HCC. This manuscript
has the following issues.
1, The results of colony formation in Figure 2F are not significant, please repeat these
experiments.
2, The Statistical charts lack Horizontal braces under asterisk.
3, Please make Statistical charts about the relationship between ARID1A and immune signatures
in Figure 4.
4, Please discuss the reasons about Inconsistent results in different cell lines in Figure 5b and c.
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