Title: Serum Superoxide Dismutase Level Is a Potential Biomarker of Disease Prognosis in
Patients with HEV-induced Liver Failure
Version: 0 Date: 05 Nov 2021
Reviewer:  Premashish Kar
Reviewer's report:
For establishing the diagnosis of HEV infection ,did u include IGM antihev and HEV RNA
positivity or either of them .This is not clear from this paper .HEV leads to oxidative stress and
HMGB1 release which causes apoptosis of the hepatocytes .In this hypothesis the author tried
in the same sample size which could have been a different study.How does the authors explain
the remission of the SOD levels in the remission stage compared to the progressive stage
Title: Serum Superoxide Dismutase Level Is a Potential Biomarker of Disease Prognosis in
Patients with HEV-induced Liver Failure
Version: 0 Date: 05 Nov 2021
Reviewer:  Premashish Kar
Reviewer's report:
For establishing the diagnosis of HEV infection ,did u include IGM antihev and HEV RNA
positivity or either of them .This is not clear from this paper .HEV leads to oxidative stress and
HMGB1 release which causes apoptosis of the hepatocytes .In this hypothesis the author tried
in the same sample size which could have been a different study.How does the authors explain
the remission of the SOD levels in the remission stage compared to the progressive stage
Please review this paper.
user
Title: Serum Superoxide Dismutase Level Is a Potential Biomarker of Disease Prognosis in
Patients with HEV-induced Liver Failure
Version: 0 Date: 05 Nov 2021
Reviewer:  Premashish Kar
Reviewer's report:
For establishing the diagnosis of HEV infection ,did u include IGM antihev and HEV RNA
positivity or either of them .This is not clear from this paper .HEV leads to oxidative stress and
HMGB1 release which causes apoptosis of the hepatocytes .In this hypothesis the author tried
in the same sample size which could have been a different study.How does the authors explain
the remission of the SOD levels in the remission stage compared to the progressive stage
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