Title: Investigating Neutropenic Enterocolitis: A Systematic Review of Case Reports and
Clinical Insights
Version: 1 Date: 19 Nov 2024
Reviewer:  Amira A A Othman
Reviewer's report:
This comprehensive systematic review and meta-analysis provides valuable insights into
the epidemiology, clinical presentation, management approaches, outcomes, and risk factors
associated with neutropenic enterocolitis (NE).
The study performed a comprehensive analysis, it aggregates 227 cases from 159 publications,
representing one of the largest reviews on this topic, following the PRISMA guidelines for
systematic reviews. The study provides a detailed description of NE risk factors, symptoms,
microbiological findings, treatment approaches, prognosis, and potential predictors of mortality
to enhance clinical awareness and management of this condition. The study also emphasizes
geographical variations in reported cases, aiding the understanding of global NE patterns.
The authors tried to contribute to this field of research with new findings, nevertheless, there is
an observation for which sufficient justification must be obtained.
1. The study's reliance on case reports and series, which are prone to selection bias and lack
cross-study consistency, is the reason for its low level of evidence.
2. The robustness of mortality risk projections was diminished since the generalized estimating
equations (GEE) analysis did not yield statistically significant results.
3. Because of the length of cases, older diagnostic and treatment techniques might not be
applicable in modern situations.
4. Insufficient microbiological data, with positive stool or blood cultures in only a small
percentage of cases, and a lack of severity rating and thorough treatment regimens in many
studies are examples of data gaps.
5. Limited microbiological data, with positive stool or blood cultures in only a small percentage
of cases, and a lack of severity rating and thorough treatment regimens in many studies are
examples of data gaps.
To address these limitations, the authors advise carrying up prospective studies with uniform
data collecting and reporting to address these shortcomings and offer a higher degree of proof.
The effects of more recent diagnostic techniques and therapeutic modalities on the management
and results of NE also require investigation. However, this systematic analysis provides
insightful information that can help clinicians identify this potentially fatal complication early
and treat it aggressively.
Title: Investigating Neutropenic Enterocolitis: A Systematic Review of Case Reports and
Clinical Insights
Version: 1 Date: 19 Nov 2024
Reviewer:  Amira A A Othman
Reviewer's report:
This comprehensive systematic review and meta-analysis provides valuable insights into
the epidemiology, clinical presentation, management approaches, outcomes, and risk factors
associated with neutropenic enterocolitis (NE).
The study performed a comprehensive analysis, it aggregates 227 cases from 159 publications,
representing one of the largest reviews on this topic, following the PRISMA guidelines for
systematic reviews. The study provides a detailed description of NE risk factors, symptoms,
microbiological findings, treatment approaches, prognosis, and potential predictors of mortality
to enhance clinical awareness and management of this condition. The study also emphasizes
geographical variations in reported cases, aiding the understanding of global NE patterns.
The authors tried to contribute to this field of research with new findings, nevertheless, there is
an observation for which sufficient justification must be obtained.
1. The study's reliance on case reports and series, which are prone to selection bias and lack
cross-study consistency, is the reason for its low level of evidence.
2. The robustness of mortality risk projections was diminished since the generalized estimating
equations (GEE) analysis did not yield statistically significant results.
3. Because of the length of cases, older diagnostic and treatment techniques might not be
applicable in modern situations.
4. Insufficient microbiological data, with positive stool or blood cultures in only a small
percentage of cases, and a lack of severity rating and thorough treatment regimens in many
studies are examples of data gaps.
5. Limited microbiological data, with positive stool or blood cultures in only a small percentage
of cases, and a lack of severity rating and thorough treatment regimens in many studies are
examples of data gaps.
To address these limitations, the authors advise carrying up prospective studies with uniform
data collecting and reporting to address these shortcomings and offer a higher degree of proof.
The effects of more recent diagnostic techniques and therapeutic modalities on the management
and results of NE also require investigation. However, this systematic analysis provides
insightful information that can help clinicians identify this potentially fatal complication early
and treat it aggressively.
Please review this paper.
user
Title: Investigating Neutropenic Enterocolitis: A Systematic Review of Case Reports and
Clinical Insights
Version: 1 Date: 19 Nov 2024
Reviewer:  Amira A A Othman
Reviewer's report:
This comprehensive systematic review and meta-analysis provides valuable insights into
the epidemiology, clinical presentation, management approaches, outcomes, and risk factors
associated with neutropenic enterocolitis (NE).
The study performed a comprehensive analysis, it aggregates 227 cases from 159 publications,
representing one of the largest reviews on this topic, following the PRISMA guidelines for
systematic reviews. The study provides a detailed description of NE risk factors, symptoms,
microbiological findings, treatment approaches, prognosis, and potential predictors of mortality
to enhance clinical awareness and management of this condition. The study also emphasizes
geographical variations in reported cases, aiding the understanding of global NE patterns.
The authors tried to contribute to this field of research with new findings, nevertheless, there is
an observation for which sufficient justification must be obtained.
1. The study's reliance on case reports and series, which are prone to selection bias and lack
cross-study consistency, is the reason for its low level of evidence.
2. The robustness of mortality risk projections was diminished since the generalized estimating
equations (GEE) analysis did not yield statistically significant results.
3. Because of the length of cases, older diagnostic and treatment techniques might not be
applicable in modern situations.
4. Insufficient microbiological data, with positive stool or blood cultures in only a small
percentage of cases, and a lack of severity rating and thorough treatment regimens in many
studies are examples of data gaps.
5. Limited microbiological data, with positive stool or blood cultures in only a small percentage
of cases, and a lack of severity rating and thorough treatment regimens in many studies are
examples of data gaps.
To address these limitations, the authors advise carrying up prospective studies with uniform
data collecting and reporting to address these shortcomings and offer a higher degree of proof.
The effects of more recent diagnostic techniques and therapeutic modalities on the management
and results of NE also require investigation. However, this systematic analysis provides
insightful information that can help clinicians identify this potentially fatal complication early
and treat it aggressively.
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