Reviewer's report
Title:A novel biomarker TERTmRNA is applicable for early detection of
hepatoma
Version: 2Date:23 December 2009
Reviewer: Hans Spangenberg
Reviewer's report:
The authors have answered to most of the points of the reviewers. however
some important questions have not been solved and should defintely be
answered prior to publication.
In my opinion it should be possible to better match the control patients with the
HCC patients. This needs further experiments, however, this is crucial for the
importance of the findings.
Furthermore comparable studies with hTERT are not sufficiently be addressed in
the paper.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:A novel biomarker TERTmRNA is applicable for early detection of
hepatoma
Version: 2Date:23 December 2009
Reviewer: Hans Spangenberg
Reviewer's report:
The authors have answered to most of the points of the reviewers. however
some important questions have not been solved and should defintely be
answered prior to publication.
In my opinion it should be possible to better match the control patients with the
HCC patients. This needs further experiments, however, this is crucial for the
importance of the findings.
Furthermore comparable studies with hTERT are not sufficiently be addressed in
the paper.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:A novel biomarker TERTmRNA is applicable for early detection of
hepatoma
Version: 2Date:23 December 2009
Reviewer: Hans Spangenberg
Reviewer's report:
The authors have answered to most of the points of the reviewers. however
some important questions have not been solved and should defintely be
answered prior to publication.
In my opinion it should be possible to better match the control patients with the
HCC patients. This needs further experiments, however, this is crucial for the
importance of the findings.
Furthermore comparable studies with hTERT are not sufficiently be addressed in
the paper.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant