Title: Chemotherapy alone vs definitive concurrent chemoradiotherapy for cT4b esophageal
squamous cell carcinoma: a population based study
Version: 2 Date: 27 Feb 2021
Reviewer's report:
This is a thorough review of Taiwan registry data and the authors should be congratulated on
the lengths they have gone to appropriately analyse the data
It is stated that median follow up in the results (study population) was just 7 months and it is
unclear why such a short time given the duration of the review (unless limited by death?)
Was there any data on complications of radiotherapy treatment (eg fistula, rupture aorta etc) and
if not specifically rates or death within 3 months of completing high dose RT?
I would recommend changing the language such that the tense is present, ie the guidelines
currently show xx rather than did show yy
Title: Chemotherapy alone vs definitive concurrent chemoradiotherapy for cT4b esophageal
squamous cell carcinoma: a population based study
Version: 2 Date: 27 Feb 2021
Reviewer's report:
This is a thorough review of Taiwan registry data and the authors should be congratulated on
the lengths they have gone to appropriately analyse the data
It is stated that median follow up in the results (study population) was just 7 months and it is
unclear why such a short time given the duration of the review (unless limited by death?)
Was there any data on complications of radiotherapy treatment (eg fistula, rupture aorta etc) and
if not specifically rates or death within 3 months of completing high dose RT?
I would recommend changing the language such that the tense is present, ie the guidelines
currently show xx rather than did show yy
Please review this paper.
user
Title: Chemotherapy alone vs definitive concurrent chemoradiotherapy for cT4b esophageal
squamous cell carcinoma: a population based study
Version: 2 Date: 27 Feb 2021
Reviewer's report:
This is a thorough review of Taiwan registry data and the authors should be congratulated on
the lengths they have gone to appropriately analyse the data
It is stated that median follow up in the results (study population) was just 7 months and it is
unclear why such a short time given the duration of the review (unless limited by death?)
Was there any data on complications of radiotherapy treatment (eg fistula, rupture aorta etc) and
if not specifically rates or death within 3 months of completing high dose RT?
I would recommend changing the language such that the tense is present, ie the guidelines
currently show xx rather than did show yy
assistant