Reviewer's report
Title:Leiomyosarcoma of sigmoid colon with multiple liver metastases and
gastric cancer: case report
Version: 1Date:4 May 2012
Reviewer: Ingmar Ipach
Reviewer's report:
Dear authors,
you are reporting a really interesting case. You are totally right, Leiomyosarcoma
of the large bowl are really rare. Especially the addition with a gastric cancer and
the diagnostic dilemma make this case worth getting published in BMC
Gastroenterology.
The immunophenotype especially the lack of KIT in LMS (in contrast to GIST) is
very important and you have pointed out this clearly.
Major compulsory revision
In the discussion you illuminate the diagnostic dilemma with liver metastasis.
Would you also perform a resection after primary diagnosis of a LMS on the
other hand it is very unusual to perform a resection of liver metastasis after the
diagnosis of a leiomyosarcoma.
You should also include a section with the possibility of a LMS-metastasis in the
large bowl and liver after an LMS of the soft tissue, as recently published (J Clin
Oncol. 2011 Nov 20;29(33):e799-802)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
The reviewer declare no compenting interests
Reviewer's report
Title:Leiomyosarcoma of sigmoid colon with multiple liver metastases and
gastric cancer: case report
Version: 1Date:4 May 2012
Reviewer: Ingmar Ipach
Reviewer's report:
Dear authors,
you are reporting a really interesting case. You are totally right, Leiomyosarcoma
of the large bowl are really rare. Especially the addition with a gastric cancer and
the diagnostic dilemma make this case worth getting published in BMC
Gastroenterology.
The immunophenotype especially the lack of KIT in LMS (in contrast to GIST) is
very important and you have pointed out this clearly.
Major compulsory revision
In the discussion you illuminate the diagnostic dilemma with liver metastasis.
Would you also perform a resection after primary diagnosis of a LMS on the
other hand it is very unusual to perform a resection of liver metastasis after the
diagnosis of a leiomyosarcoma.
You should also include a section with the possibility of a LMS-metastasis in the
large bowl and liver after an LMS of the soft tissue, as recently published (J Clin
Oncol. 2011 Nov 20;29(33):e799-802)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
The reviewer declare no compenting interests
Please review this paper.
user
Reviewer's report
Title:Leiomyosarcoma of sigmoid colon with multiple liver metastases and
gastric cancer: case report
Version: 1Date:4 May 2012
Reviewer: Ingmar Ipach
Reviewer's report:
Dear authors,
you are reporting a really interesting case. You are totally right, Leiomyosarcoma
of the large bowl are really rare. Especially the addition with a gastric cancer and
the diagnostic dilemma make this case worth getting published in BMC
Gastroenterology.
The immunophenotype especially the lack of KIT in LMS (in contrast to GIST) is
very important and you have pointed out this clearly.
Major compulsory revision
In the discussion you illuminate the diagnostic dilemma with liver metastasis.
Would you also perform a resection after primary diagnosis of a LMS on the
other hand it is very unusual to perform a resection of liver metastasis after the
diagnosis of a leiomyosarcoma.
You should also include a section with the possibility of a LMS-metastasis in the
large bowl and liver after an LMS of the soft tissue, as recently published (J Clin
Oncol. 2011 Nov 20;29(33):e799-802)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
The reviewer declare no compenting interests
assistant