Title: Evaluating the Role of Circadian Syndrome in Predicting MASLD Risk: Evidence from
a Large Cross-Sectional Study
Version: 0 Date: 23 Apr 2025
Reviewer's report:
Thank you so much for your invitation to review this manuscript. Sun et al. presented a cross-
sectional analysis using data from the 2017–2018 NHANES cycle to investigate the association
between CircS and MASLD. The following comments might be considered to improve the
manuscript further.
Major comments:
1. Introduction: The authors might provide a clearer rationale for specifically investigating CircS
as a predictor of MASLD by introducing the previous attempts, if there are any, and the gap
in existing literature.
2. Methods: The authors might consider adding the source for those cutoffs that were used in
the analysis.
3. Methods: How were those covariates selected? Did the authors do any sensitivity analysis or
stratified analyses for any of these?
4. Discussion: The authors might expand on the potential biological mechanisms underlying the
observed association and also the clinical implications of the findings.
Minor comments:
1. Check the label and reference all figures and tables in the text to improve readability.
Title: Evaluating the Role of Circadian Syndrome in Predicting MASLD Risk: Evidence from
a Large Cross-Sectional Study
Version: 0 Date: 23 Apr 2025
Reviewer's report:
Thank you so much for your invitation to review this manuscript. Sun et al. presented a cross-
sectional analysis using data from the 2017–2018 NHANES cycle to investigate the association
between CircS and MASLD. The following comments might be considered to improve the
manuscript further.
Major comments:
1. Introduction: The authors might provide a clearer rationale for specifically investigating CircS
as a predictor of MASLD by introducing the previous attempts, if there are any, and the gap
in existing literature.
2. Methods: The authors might consider adding the source for those cutoffs that were used in
the analysis.
3. Methods: How were those covariates selected? Did the authors do any sensitivity analysis or
stratified analyses for any of these?
4. Discussion: The authors might expand on the potential biological mechanisms underlying the
observed association and also the clinical implications of the findings.
Minor comments:
1. Check the label and reference all figures and tables in the text to improve readability.
Please review this paper.
user
Title: Evaluating the Role of Circadian Syndrome in Predicting MASLD Risk: Evidence from
a Large Cross-Sectional Study
Version: 0 Date: 23 Apr 2025
Reviewer's report:
Thank you so much for your invitation to review this manuscript. Sun et al. presented a cross-
sectional analysis using data from the 2017–2018 NHANES cycle to investigate the association
between CircS and MASLD. The following comments might be considered to improve the
manuscript further.
Major comments:
1. Introduction: The authors might provide a clearer rationale for specifically investigating CircS
as a predictor of MASLD by introducing the previous attempts, if there are any, and the gap
in existing literature.
2. Methods: The authors might consider adding the source for those cutoffs that were used in
the analysis.
3. Methods: How were those covariates selected? Did the authors do any sensitivity analysis or
stratified analyses for any of these?
4. Discussion: The authors might expand on the potential biological mechanisms underlying the
observed association and also the clinical implications of the findings.
Minor comments:
1. Check the label and reference all figures and tables in the text to improve readability.
assistant