Reviewer's report
Title:Management of patients with biliary sphincter of Oddi disorder without
sphincter of Oddi manometry
Version: 1Date:21 July 2010
Reviewer: Benedetto Mangiavillano
Reviewer's report:
Major Revisions
1. Did the patients performing ERCP plus EBS undergo ERCP pharmacological
prophylaxis with anti-proteasic drugs (es. Gabexate-mesilate)?
2. Please create a flow-chart on the management of these patients.
3. Please report your results in a table to be more simply for the readers.
4. In the section “Results- ERCP and sphincterotomy”: please specify if the
patients undergone ERCP had other risk factors for post-ERCP pancreatitis
(PEP). See: “Risk factors for pancreatitis following endoscopic retrograde
cholangiopancreatography: a meta-analysis. Masci E, Mariani A, Curioni S,
Testoni PA. Endoscopy. 2003 Oct;35(10):830-4”. Did you perform pre-cut
technique during the ERCP? How many of these had sludge/stones? Please
create a table with risk factors, technique, n° of ERCP and outcome of the
patients undergone sphincterotomy.
5. Please report the percentage of PEP after the first ERCP in the EBS treated
patients. You reported a 18% of complications (9 complications on 50 ERCP) but
the treated patients were 24.
6. In the abstract (Results) is reported seventy-eight % of complications. Is it a
correct data?
Minor Revisions
1. In the ”Methods – Patients” and “Methods – Management” section, first line,
please substitute “patients with biliary SOD...” with “patients with a clinical
diagnosis of SOD”.
2. Delete the last sentences in the “conclusions” in the abstract, discussing the
possible multifactorial origin of the SOD pain.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Management of patients with biliary sphincter of Oddi disorder without
sphincter of Oddi manometry
Version: 1Date:21 July 2010
Reviewer: Benedetto Mangiavillano
Reviewer's report:
Major Revisions
1. Did the patients performing ERCP plus EBS undergo ERCP pharmacological
prophylaxis with anti-proteasic drugs (es. Gabexate-mesilate)?
2. Please create a flow-chart on the management of these patients.
3. Please report your results in a table to be more simply for the readers.
4. In the section “Results- ERCP and sphincterotomy”: please specify if the
patients undergone ERCP had other risk factors for post-ERCP pancreatitis
(PEP). See: “Risk factors for pancreatitis following endoscopic retrograde
cholangiopancreatography: a meta-analysis. Masci E, Mariani A, Curioni S,
Testoni PA. Endoscopy. 2003 Oct;35(10):830-4”. Did you perform pre-cut
technique during the ERCP? How many of these had sludge/stones? Please
create a table with risk factors, technique, n° of ERCP and outcome of the
patients undergone sphincterotomy.
5. Please report the percentage of PEP after the first ERCP in the EBS treated
patients. You reported a 18% of complications (9 complications on 50 ERCP) but
the treated patients were 24.
6. In the abstract (Results) is reported seventy-eight % of complications. Is it a
correct data?
Minor Revisions
1. In the ”Methods – Patients” and “Methods – Management” section, first line,
please substitute “patients with biliary SOD...” with “patients with a clinical
diagnosis of SOD”.
2. Delete the last sentences in the “conclusions” in the abstract, discussing the
possible multifactorial origin of the SOD pain.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Management of patients with biliary sphincter of Oddi disorder without
sphincter of Oddi manometry
Version: 1Date:21 July 2010
Reviewer: Benedetto Mangiavillano
Reviewer's report:
Major Revisions
1. Did the patients performing ERCP plus EBS undergo ERCP pharmacological
prophylaxis with anti-proteasic drugs (es. Gabexate-mesilate)?
2. Please create a flow-chart on the management of these patients.
3. Please report your results in a table to be more simply for the readers.
4. In the section “Results- ERCP and sphincterotomy”: please specify if the
patients undergone ERCP had other risk factors for post-ERCP pancreatitis
(PEP). See: “Risk factors for pancreatitis following endoscopic retrograde
cholangiopancreatography: a meta-analysis. Masci E, Mariani A, Curioni S,
Testoni PA. Endoscopy. 2003 Oct;35(10):830-4”. Did you perform pre-cut
technique during the ERCP? How many of these had sludge/stones? Please
create a table with risk factors, technique, n° of ERCP and outcome of the
patients undergone sphincterotomy.
5. Please report the percentage of PEP after the first ERCP in the EBS treated
patients. You reported a 18% of complications (9 complications on 50 ERCP) but
the treated patients were 24.
6. In the abstract (Results) is reported seventy-eight % of complications. Is it a
correct data?
Minor Revisions
1. In the ”Methods – Patients” and “Methods – Management” section, first line,
please substitute “patients with biliary SOD...” with “patients with a clinical
diagnosis of SOD”.
2. Delete the last sentences in the “conclusions” in the abstract, discussing the
possible multifactorial origin of the SOD pain.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant