Reviewer ’s report  
 
Title: Outcomes of liver –kidney transplantation in patients with primary hyperoxaluria: an  
analysis of the Scientific Registry of Transplant Recipients database  
 
Version: 0 Date: 22 May 2020  
 
Reviewer's report:  
 
In this study, the authors aimed to clarify the differences between liver -kidney transplantation 
(CLKT) and sequential liver and kidney transplantation (SLKT) in patients with primary 
hyperoxaluria (PH). The authors included 201 patients wi th PH who received both liver and 
kidney transplants and who were listed on the Scientific Registry of Transplant Recipients from 
1987 to 2018. The authors demonstrated that SLKT seems to be an alternative option with strict 
condition for CLKT, further exp loration about the SLKT is still required. Overall, the data 
provided here by the authors could have interesting implications. Specific points of view need to 
be considered are listed below:  
 
1. Since published research about SLKT is limited, it would be better to include some more of 
the previous studies on SLKT in the Introduction.  
 
2. It's necessary to include the units for the serum levels of liver/kidney function tests.  
 
3. The authors need  to write Figure Legends for all the figures.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in  your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explai n in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessme nt in your comments to the editors.  
 
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
Reviewer Publication Consent. I agree for my report to be made available under an Open 
Access  Creative Commons CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if this 
manuscript  is accepted for publication. Any comments that I do not wish to be included in the 
published  report have been included as confidential comments to the editor, which will not be 
published.  If you are not happy for us to publish this report, please contact the  editorial office 
before completing  the review.  If you wish, you can include your name in your published report. 
Please note you must  decide whether to include your name at the start of the process and confirm 
this decision whenever  prompted. If you change your decision later, we will not be able to 
publish your name.  
 
I agree to the terms of the CC -BY 4.0 license; please do not publish my name with my report.  
(default)  
Reviewer ’s report  
 
Title: Outcomes of liver –kidney transplantation in patients with primary hyperoxaluria: an  
analysis of the Scientific Registry of Transplant Recipients database  
 
Version: 0 Date: 22 May 2020  
 
Reviewer's report:  
 
In this study, the authors aimed to clarify the differences between liver -kidney transplantation 
(CLKT) and sequential liver and kidney transplantation (SLKT) in patients with primary 
hyperoxaluria (PH). The authors included 201 patients wi th PH who received both liver and 
kidney transplants and who were listed on the Scientific Registry of Transplant Recipients from 
1987 to 2018. The authors demonstrated that SLKT seems to be an alternative option with strict 
condition for CLKT, further exp loration about the SLKT is still required. Overall, the data 
provided here by the authors could have interesting implications. Specific points of view need to 
be considered are listed below:  
 
1. Since published research about SLKT is limited, it would be better to include some more of 
the previous studies on SLKT in the Introduction.  
 
2. It's necessary to include the units for the serum levels of liver/kidney function tests.  
 
3. The authors need  to write Figure Legends for all the figures.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in  your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explai n in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessme nt in your comments to the editors.  
 
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
Reviewer Publication Consent. I agree for my report to be made available under an Open 
Access  Creative Commons CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if this 
manuscript  is accepted for publication. Any comments that I do not wish to be included in the 
published  report have been included as confidential comments to the editor, which will not be 
published.  If you are not happy for us to publish this report, please contact the  editorial office 
before completing  the review.  If you wish, you can include your name in your published report. 
Please note you must  decide whether to include your name at the start of the process and confirm 
this decision whenever  prompted. If you change your decision later, we will not be able to 
publish your name.  
 
I agree to the terms of the CC -BY 4.0 license; please do not publish my name with my report.  
(default)  
Please review this paper.
user
Reviewer ’s report  
 
Title: Outcomes of liver –kidney transplantation in patients with primary hyperoxaluria: an  
analysis of the Scientific Registry of Transplant Recipients database  
 
Version: 0 Date: 22 May 2020  
 
Reviewer's report:  
 
In this study, the authors aimed to clarify the differences between liver -kidney transplantation 
(CLKT) and sequential liver and kidney transplantation (SLKT) in patients with primary 
hyperoxaluria (PH). The authors included 201 patients wi th PH who received both liver and 
kidney transplants and who were listed on the Scientific Registry of Transplant Recipients from 
1987 to 2018. The authors demonstrated that SLKT seems to be an alternative option with strict 
condition for CLKT, further exp loration about the SLKT is still required. Overall, the data 
provided here by the authors could have interesting implications. Specific points of view need to 
be considered are listed below:  
 
1. Since published research about SLKT is limited, it would be better to include some more of 
the previous studies on SLKT in the Introduction.  
 
2. It's necessary to include the units for the serum levels of liver/kidney function tests.  
 
3. The authors need  to write Figure Legends for all the figures.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in  your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explai n in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessme nt in your comments to the editors.  
 
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
Reviewer Publication Consent. I agree for my report to be made available under an Open 
Access  Creative Commons CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if this 
manuscript  is accepted for publication. Any comments that I do not wish to be included in the 
published  report have been included as confidential comments to the editor, which will not be 
published.  If you are not happy for us to publish this report, please contact the  editorial office 
before completing  the review.  If you wish, you can include your name in your published report. 
Please note you must  decide whether to include your name at the start of the process and confirm 
this decision whenever  prompted. If you change your decision later, we will not be able to 
publish your name.  
 
I agree to the terms of the CC -BY 4.0 license; please do not publish my name with my report.  
(default)  
assistant