Reviewer's report 
 Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary Title: 
infection: Case report 
 3  27 November 2005 Version: Date: 
 Daniel Seehofer Reviewer: 
Reviewer's report: 
General 
The authors present a well documented case report that suggest an association between CMV infection and portal plus hepatic vein thrombosis. All relevant clinical and work-up data are given. The association between CMV infection and vascular thrombosis at different localizations has been 
described in several case reports. Most of them have been found in women in the thirties taking oral 
contraceptives or having other risk factors for venous thromoses. However, the association between 
CMV and Budd Chiari syndorme in immunocompetent patients has not been described previously. 
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Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) none 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
none 
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Discretionary Revisions (which the author can choose to ignore) 
It would be interesting to know, if this poatient has a history of smoking as further risk factor. 
 Accept after discretionary revisions What next?: 
 An article of importance in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests 
Reviewer's report 
 Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary Title: 
infection: Case report 
 3  27 November 2005 Version: Date: 
 Daniel Seehofer Reviewer: 
Reviewer's report: 
General 
The authors present a well documented case report that suggest an association between CMV infection and portal plus hepatic vein thrombosis. All relevant clinical and work-up data are given. The association between CMV infection and vascular thrombosis at different localizations has been 
described in several case reports. Most of them have been found in women in the thirties taking oral 
contraceptives or having other risk factors for venous thromoses. However, the association between 
CMV and Budd Chiari syndorme in immunocompetent patients has not been described previously. 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) none 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
none 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
It would be interesting to know, if this poatient has a history of smoking as further risk factor. 
 Accept after discretionary revisions What next?: 
 An article of importance in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests 
Please review this paper.
user
Reviewer's report 
 Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary Title: 
infection: Case report 
 3  27 November 2005 Version: Date: 
 Daniel Seehofer Reviewer: 
Reviewer's report: 
General 
The authors present a well documented case report that suggest an association between CMV infection and portal plus hepatic vein thrombosis. All relevant clinical and work-up data are given. The association between CMV infection and vascular thrombosis at different localizations has been 
described in several case reports. Most of them have been found in women in the thirties taking oral 
contraceptives or having other risk factors for venous thromoses. However, the association between 
CMV and Budd Chiari syndorme in immunocompetent patients has not been described previously. 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) none 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
none 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
It would be interesting to know, if this poatient has a history of smoking as further risk factor. 
 Accept after discretionary revisions What next?: 
 An article of importance in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
I declare that I have no competing interests 
assistant