Title: Global Burden, Temporal Trends, and Health Workforce Correlations of Gallbladder and
Biliary Tract Cancer: A Comprehensive Analysis from 1990 to 2021 with Projections to 2046
Version: 0 Date: 13 May 2025
Reviewer:  Mahsa Heidari-Foroozan
Reviewer's report:
This paper provides a well-structured analysis of the global burden of gallbladder and biliary
tract cancers. With some revisions, it has the potential to be suitable for publication. Below are
specific suggestions to strengthen the manuscript:
Abstract:
The objective should focus on the key burden measures assessed rather than mentioning DALYs
generically.
Please specify which burden metrics (e.g., incidence, mortality, disability-adjusted life years)
were calculated in the Methods section.
The conclusion is currently too broad and could apply to any disease burden study. It should be
revised to highlight unique findings specific to gallbladder and biliary tract cancers.
Methods:
The section on the Global Burden of Disease (GBD) methodology should be expanded to provide
a clearer explanation of the data sources, modeling approaches, and adjustments used.
The decomposition analysis requires a more detailed description, including its purpose,
methodology, and how it contributes to the study’s findings.
Results:
The Results section is well-presented and effectively communicates key data. No major revisions
are needed here.
Discussion:
To strengthen the context, please incorporate more comparisons with prior literature, discussing
how your findings align with or differ from existing studies.
The discussion should also include actionable recommendations for policymakers, addressing
how the study’s results could inform public health strategies.
Title: Global Burden, Temporal Trends, and Health Workforce Correlations of Gallbladder and
Biliary Tract Cancer: A Comprehensive Analysis from 1990 to 2021 with Projections to 2046
Version: 0 Date: 13 May 2025
Reviewer:  Mahsa Heidari-Foroozan
Reviewer's report:
This paper provides a well-structured analysis of the global burden of gallbladder and biliary
tract cancers. With some revisions, it has the potential to be suitable for publication. Below are
specific suggestions to strengthen the manuscript:
Abstract:
The objective should focus on the key burden measures assessed rather than mentioning DALYs
generically.
Please specify which burden metrics (e.g., incidence, mortality, disability-adjusted life years)
were calculated in the Methods section.
The conclusion is currently too broad and could apply to any disease burden study. It should be
revised to highlight unique findings specific to gallbladder and biliary tract cancers.
Methods:
The section on the Global Burden of Disease (GBD) methodology should be expanded to provide
a clearer explanation of the data sources, modeling approaches, and adjustments used.
The decomposition analysis requires a more detailed description, including its purpose,
methodology, and how it contributes to the study’s findings.
Results:
The Results section is well-presented and effectively communicates key data. No major revisions
are needed here.
Discussion:
To strengthen the context, please incorporate more comparisons with prior literature, discussing
how your findings align with or differ from existing studies.
The discussion should also include actionable recommendations for policymakers, addressing
how the study’s results could inform public health strategies.
Please review this paper.
user
Title: Global Burden, Temporal Trends, and Health Workforce Correlations of Gallbladder and
Biliary Tract Cancer: A Comprehensive Analysis from 1990 to 2021 with Projections to 2046
Version: 0 Date: 13 May 2025
Reviewer:  Mahsa Heidari-Foroozan
Reviewer's report:
This paper provides a well-structured analysis of the global burden of gallbladder and biliary
tract cancers. With some revisions, it has the potential to be suitable for publication. Below are
specific suggestions to strengthen the manuscript:
Abstract:
The objective should focus on the key burden measures assessed rather than mentioning DALYs
generically.
Please specify which burden metrics (e.g., incidence, mortality, disability-adjusted life years)
were calculated in the Methods section.
The conclusion is currently too broad and could apply to any disease burden study. It should be
revised to highlight unique findings specific to gallbladder and biliary tract cancers.
Methods:
The section on the Global Burden of Disease (GBD) methodology should be expanded to provide
a clearer explanation of the data sources, modeling approaches, and adjustments used.
The decomposition analysis requires a more detailed description, including its purpose,
methodology, and how it contributes to the study’s findings.
Results:
The Results section is well-presented and effectively communicates key data. No major revisions
are needed here.
Discussion:
To strengthen the context, please incorporate more comparisons with prior literature, discussing
how your findings align with or differ from existing studies.
The discussion should also include actionable recommendations for policymakers, addressing
how the study’s results could inform public health strategies.
assistant