Title: Adherence to infliximab treatment in patients with immune-mediated inflammatory
diseases from a Referral Center in Brazil: A cohort study
Version: 2 Date: 15 Aug 2024
Reviewer:  Abel Quaresma
Reviewer's report:
Q1: In the abstract, it is stated: "Individuals with inflammatory bowel diseases had a 39.1%
higher risk of non-adherence to treatment compared with other patients." I suggest adding "in
our sample" because this result was found in the study sample and does not represent a general
data from the literature. Additionally, mentioning that this finding was significant (p < 0.025)
would enhance the abstract’s clarity.
Q2: The methods section notes that patients who did not respond to treatment were excluded
from the sample. This information should be included in the abstract, as it is well known
that a positive treatment response influences adherence. When only patients who responded to
treatment are evaluated, higher adherence rates are expected compared to if these patients were
included in the total sample. This is an important detail that should be included in the abstract.
Q3: In the conclusion, it is written: "As the study site is a reference unit with multidisciplinary
care and continuous monitoring of effectiveness, safety, and treatment adherence, the welcoming
and good degree of communication between professionals and patients may have contributed
to the high adherence rates." These details seem more relevant to the discussion than to the
conclusion. It would be clearer to conclude that: "Reception and a good level of communication
between professionals and patients can contribute to higher adherence rates."
Q4: In the references, two different fonts (Times New Roman and Arial) and two different
citation styles were found, which should be standardized (citations 2 and 3).
Title: Adherence to infliximab treatment in patients with immune-mediated inflammatory
diseases from a Referral Center in Brazil: A cohort study
Version: 2 Date: 15 Aug 2024
Reviewer:  Abel Quaresma
Reviewer's report:
Q1: In the abstract, it is stated: "Individuals with inflammatory bowel diseases had a 39.1%
higher risk of non-adherence to treatment compared with other patients." I suggest adding "in
our sample" because this result was found in the study sample and does not represent a general
data from the literature. Additionally, mentioning that this finding was significant (p < 0.025)
would enhance the abstract’s clarity.
Q2: The methods section notes that patients who did not respond to treatment were excluded
from the sample. This information should be included in the abstract, as it is well known
that a positive treatment response influences adherence. When only patients who responded to
treatment are evaluated, higher adherence rates are expected compared to if these patients were
included in the total sample. This is an important detail that should be included in the abstract.
Q3: In the conclusion, it is written: "As the study site is a reference unit with multidisciplinary
care and continuous monitoring of effectiveness, safety, and treatment adherence, the welcoming
and good degree of communication between professionals and patients may have contributed
to the high adherence rates." These details seem more relevant to the discussion than to the
conclusion. It would be clearer to conclude that: "Reception and a good level of communication
between professionals and patients can contribute to higher adherence rates."
Q4: In the references, two different fonts (Times New Roman and Arial) and two different
citation styles were found, which should be standardized (citations 2 and 3).
Please review this paper.
user
Title: Adherence to infliximab treatment in patients with immune-mediated inflammatory
diseases from a Referral Center in Brazil: A cohort study
Version: 2 Date: 15 Aug 2024
Reviewer:  Abel Quaresma
Reviewer's report:
Q1: In the abstract, it is stated: "Individuals with inflammatory bowel diseases had a 39.1%
higher risk of non-adherence to treatment compared with other patients." I suggest adding "in
our sample" because this result was found in the study sample and does not represent a general
data from the literature. Additionally, mentioning that this finding was significant (p < 0.025)
would enhance the abstract’s clarity.
Q2: The methods section notes that patients who did not respond to treatment were excluded
from the sample. This information should be included in the abstract, as it is well known
that a positive treatment response influences adherence. When only patients who responded to
treatment are evaluated, higher adherence rates are expected compared to if these patients were
included in the total sample. This is an important detail that should be included in the abstract.
Q3: In the conclusion, it is written: "As the study site is a reference unit with multidisciplinary
care and continuous monitoring of effectiveness, safety, and treatment adherence, the welcoming
and good degree of communication between professionals and patients may have contributed
to the high adherence rates." These details seem more relevant to the discussion than to the
conclusion. It would be clearer to conclude that: "Reception and a good level of communication
between professionals and patients can contribute to higher adherence rates."
Q4: In the references, two different fonts (Times New Roman and Arial) and two different
citation styles were found, which should be standardized (citations 2 and 3).
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