Title: Factors contributing to flares of ulcerative colitis in North India- A case-control study
Version: 2 Date: 31 Mar 2023
Reviewer:  Bincy Abraham
Reviewer's report:
Wonderful assessment of determining etiology of flares in a specific population.
Few comments:
Did alternative meds include any ayurvedic treatment?
Also, were all the patients that took alternative meds take it after discontinuing their IBD therapy
or was it taken as adjunct therapy.
In the addiction question, was there adequate reasoning for patients to include other drugs
besides alcohol (marijuana, any illegal drug use, etc)?
It is interesting to note the very small number of biologics & small molecules.
Consider using a different term than "painkiller";
the term is suggestive of narcotic medication.
Consider pain medications
Please also clarify what were the nonNSAIDs, (was this acetominophen/ equivalent, or did this
include narcotic medications, or others? )
AFter the sentence with 22 reference, what does the (Reference) signify?  Did the authors have
another reference to place here?
*Recommend highlighting/ bolding the predictors that were significant in Table 2 and similarly
highlighting the thiopurine use that was significant in Table 1.
Title: Factors contributing to flares of ulcerative colitis in North India- A case-control study
Version: 2 Date: 31 Mar 2023
Reviewer:  Bincy Abraham
Reviewer's report:
Wonderful assessment of determining etiology of flares in a specific population.
Few comments:
Did alternative meds include any ayurvedic treatment?
Also, were all the patients that took alternative meds take it after discontinuing their IBD therapy
or was it taken as adjunct therapy.
In the addiction question, was there adequate reasoning for patients to include other drugs
besides alcohol (marijuana, any illegal drug use, etc)?
It is interesting to note the very small number of biologics & small molecules.
Consider using a different term than "painkiller";
the term is suggestive of narcotic medication.
Consider pain medications
Please also clarify what were the nonNSAIDs, (was this acetominophen/ equivalent, or did this
include narcotic medications, or others? )
AFter the sentence with 22 reference, what does the (Reference) signify?  Did the authors have
another reference to place here?
*Recommend highlighting/ bolding the predictors that were significant in Table 2 and similarly
highlighting the thiopurine use that was significant in Table 1.
Please review this paper.
user
Title: Factors contributing to flares of ulcerative colitis in North India- A case-control study
Version: 2 Date: 31 Mar 2023
Reviewer:  Bincy Abraham
Reviewer's report:
Wonderful assessment of determining etiology of flares in a specific population.
Few comments:
Did alternative meds include any ayurvedic treatment?
Also, were all the patients that took alternative meds take it after discontinuing their IBD therapy
or was it taken as adjunct therapy.
In the addiction question, was there adequate reasoning for patients to include other drugs
besides alcohol (marijuana, any illegal drug use, etc)?
It is interesting to note the very small number of biologics & small molecules.
Consider using a different term than "painkiller";
the term is suggestive of narcotic medication.
Consider pain medications
Please also clarify what were the nonNSAIDs, (was this acetominophen/ equivalent, or did this
include narcotic medications, or others? )
AFter the sentence with 22 reference, what does the (Reference) signify?  Did the authors have
another reference to place here?
*Recommend highlighting/ bolding the predictors that were significant in Table 2 and similarly
highlighting the thiopurine use that was significant in Table 1.
assistant