Reviewer's report
Title:Obesity and diabetes mellitus and/or hyperlipidaemia are independent risk
factors for pre-transplant portal venous thrombosis in liver recipients
Version: 4Date:27 June 2012
Reviewer: massimo primignani
Reviewer's report:
In this revised manuscript I have just few questions/ suggestions. The main
refers to the title of the study: since at multivariate analysis the only variable
associated with pre-transplant PVT was obesity I suggest to modify the title,
quitting diabetes and/or high lipid., as follows : "Obesity is an independent risk
factor for pre-transplant PVT in liver recipients" .
This relevant point should be more emphasized in the discussion. Moreover,
since diabetes and/or high lipid values loose their signifcance at multivariate
analysis, I suggest to taper any other conclusion ragarding this point. tAs far as
genetic thrombophilia is concerned, the fact that the rate of FV Leiden and
Prothrombin gene mutation in the study population coincide with the rate
observed in the general population proves that genetic thrombophilia has no role
in pre-transplant PVT in cirrhosis. This is an important point and should be more
emphasized
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Obesity and diabetes mellitus and/or hyperlipidaemia are independent risk
factors for pre-transplant portal venous thrombosis in liver recipients
Version: 4Date:27 June 2012
Reviewer: massimo primignani
Reviewer's report:
In this revised manuscript I have just few questions/ suggestions. The main
refers to the title of the study: since at multivariate analysis the only variable
associated with pre-transplant PVT was obesity I suggest to modify the title,
quitting diabetes and/or high lipid., as follows : "Obesity is an independent risk
factor for pre-transplant PVT in liver recipients" .
This relevant point should be more emphasized in the discussion. Moreover,
since diabetes and/or high lipid values loose their signifcance at multivariate
analysis, I suggest to taper any other conclusion ragarding this point. tAs far as
genetic thrombophilia is concerned, the fact that the rate of FV Leiden and
Prothrombin gene mutation in the study population coincide with the rate
observed in the general population proves that genetic thrombophilia has no role
in pre-transplant PVT in cirrhosis. This is an important point and should be more
emphasized
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Obesity and diabetes mellitus and/or hyperlipidaemia are independent risk
factors for pre-transplant portal venous thrombosis in liver recipients
Version: 4Date:27 June 2012
Reviewer: massimo primignani
Reviewer's report:
In this revised manuscript I have just few questions/ suggestions. The main
refers to the title of the study: since at multivariate analysis the only variable
associated with pre-transplant PVT was obesity I suggest to modify the title,
quitting diabetes and/or high lipid., as follows : "Obesity is an independent risk
factor for pre-transplant PVT in liver recipients" .
This relevant point should be more emphasized in the discussion. Moreover,
since diabetes and/or high lipid values loose their signifcance at multivariate
analysis, I suggest to taper any other conclusion ragarding this point. tAs far as
genetic thrombophilia is concerned, the fact that the rate of FV Leiden and
Prothrombin gene mutation in the study population coincide with the rate
observed in the general population proves that genetic thrombophilia has no role
in pre-transplant PVT in cirrhosis. This is an important point and should be more
emphasized
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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