Reviewer's report
Title:Testosterone-receptor positive hepatocellular carcinoma in a 29-year old
bodybuilder with a history of anabolic androgenic steroid abuse: a case report
Version:2Date:27 February 2015
Reviewer: Matias A Avila
Reviewer's report:
This is a very interesting case report. The case is well described and discussed. I
believe it is important to make this information available to the medical
community to provide adequate guidance and avoid similar situations.
I only have one Major Compulsory Revision (according to the journal's
instructions for reviewers):
It would be very helpful to determine the existence of b-catenin mutations and or
deletions in the liver lesions from this patient. It would help to relate the
use/abuse of AAS to the mechanisms that may underlie hepatic tumorigenesis.
Minor essential revisions:
Page 6, line 159: "glutamine syntahtasis" should be glutamine synthetase
Page 8, line 189: The authors state that "b-catenin is not expressed in normal
hepatocytes". This is not correct, b-catenin is expressed in normal hepatocytes.
The authors may refer to the fact that b-catenin is overexpressed in the tumoral
tissues. This should be corrected.
Page 12, line 301: "glutamin-synthetasis" should be glutamine synthetase.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Testosterone-receptor positive hepatocellular carcinoma in a 29-year old
bodybuilder with a history of anabolic androgenic steroid abuse: a case report
Version:2Date:27 February 2015
Reviewer: Matias A Avila
Reviewer's report:
This is a very interesting case report. The case is well described and discussed. I
believe it is important to make this information available to the medical
community to provide adequate guidance and avoid similar situations.
I only have one Major Compulsory Revision (according to the journal's
instructions for reviewers):
It would be very helpful to determine the existence of b-catenin mutations and or
deletions in the liver lesions from this patient. It would help to relate the
use/abuse of AAS to the mechanisms that may underlie hepatic tumorigenesis.
Minor essential revisions:
Page 6, line 159: "glutamine syntahtasis" should be glutamine synthetase
Page 8, line 189: The authors state that "b-catenin is not expressed in normal
hepatocytes". This is not correct, b-catenin is expressed in normal hepatocytes.
The authors may refer to the fact that b-catenin is overexpressed in the tumoral
tissues. This should be corrected.
Page 12, line 301: "glutamin-synthetasis" should be glutamine synthetase.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Testosterone-receptor positive hepatocellular carcinoma in a 29-year old
bodybuilder with a history of anabolic androgenic steroid abuse: a case report
Version:2Date:27 February 2015
Reviewer: Matias A Avila
Reviewer's report:
This is a very interesting case report. The case is well described and discussed. I
believe it is important to make this information available to the medical
community to provide adequate guidance and avoid similar situations.
I only have one Major Compulsory Revision (according to the journal's
instructions for reviewers):
It would be very helpful to determine the existence of b-catenin mutations and or
deletions in the liver lesions from this patient. It would help to relate the
use/abuse of AAS to the mechanisms that may underlie hepatic tumorigenesis.
Minor essential revisions:
Page 6, line 159: "glutamine syntahtasis" should be glutamine synthetase
Page 8, line 189: The authors state that "b-catenin is not expressed in normal
hepatocytes". This is not correct, b-catenin is expressed in normal hepatocytes.
The authors may refer to the fact that b-catenin is overexpressed in the tumoral
tissues. This should be corrected.
Page 12, line 301: "glutamin-synthetasis" should be glutamine synthetase.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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