Title: Combining Endoscopic variceal ligation and omeprazole sodium in treating upper
gastrointestinal hemorrhage combined with liver cirrhosis
Version: 1 Date: 02 Mar 2025
Reviewer:  Mohamed Emara
Reviewer's report:
The authors retrospectively compared 2 groups of cirrhotics with portal HTN and ruptures OVs
comparing EVL alone to EVLs with peri-endoscopic omeprazole treatment and they reported
clinical, endoscopic, hemodynamic, and laboratory superiority of the combined therapy, the
work looks interesting  and we have some comments aiming to improve quality of the work:
A- In the study design/structure: The main comments of the current study are directed to improve
the methodology section:
- Are patients treatment naive?
- What is hemostasis time? how it is calculated?
- All treatment outcome indicators should be clearly defined in the methodology section
- To avoid confusion clinical outcomes can be categorized into highly effective, effective, and
ineffective
- Total effective rate= effective+ effective????????????????????it is more clear to be highly
effective+ effective
- It is not clear how the authors judged bleeding as successfully stopped, what is the parameter
(s) used or that?
- Any predictors of efficacy in omeprazole treated group
- What is the rationale behind improved stress markers in omeprazole group
B- In manuscript writing:
- Please define some abbreviations on its first use
- Please check the attached word file for further comments
Title: Combining Endoscopic variceal ligation and omeprazole sodium in treating upper
gastrointestinal hemorrhage combined with liver cirrhosis
Version: 1 Date: 02 Mar 2025
Reviewer:  Mohamed Emara
Reviewer's report:
The authors retrospectively compared 2 groups of cirrhotics with portal HTN and ruptures OVs
comparing EVL alone to EVLs with peri-endoscopic omeprazole treatment and they reported
clinical, endoscopic, hemodynamic, and laboratory superiority of the combined therapy, the
work looks interesting  and we have some comments aiming to improve quality of the work:
A- In the study design/structure: The main comments of the current study are directed to improve
the methodology section:
- Are patients treatment naive?
- What is hemostasis time? how it is calculated?
- All treatment outcome indicators should be clearly defined in the methodology section
- To avoid confusion clinical outcomes can be categorized into highly effective, effective, and
ineffective
- Total effective rate= effective+ effective????????????????????it is more clear to be highly
effective+ effective
- It is not clear how the authors judged bleeding as successfully stopped, what is the parameter
(s) used or that?
- Any predictors of efficacy in omeprazole treated group
- What is the rationale behind improved stress markers in omeprazole group
B- In manuscript writing:
- Please define some abbreviations on its first use
- Please check the attached word file for further comments
Please review this paper.
user
Title: Combining Endoscopic variceal ligation and omeprazole sodium in treating upper
gastrointestinal hemorrhage combined with liver cirrhosis
Version: 1 Date: 02 Mar 2025
Reviewer:  Mohamed Emara
Reviewer's report:
The authors retrospectively compared 2 groups of cirrhotics with portal HTN and ruptures OVs
comparing EVL alone to EVLs with peri-endoscopic omeprazole treatment and they reported
clinical, endoscopic, hemodynamic, and laboratory superiority of the combined therapy, the
work looks interesting  and we have some comments aiming to improve quality of the work:
A- In the study design/structure: The main comments of the current study are directed to improve
the methodology section:
- Are patients treatment naive?
- What is hemostasis time? how it is calculated?
- All treatment outcome indicators should be clearly defined in the methodology section
- To avoid confusion clinical outcomes can be categorized into highly effective, effective, and
ineffective
- Total effective rate= effective+ effective????????????????????it is more clear to be highly
effective+ effective
- It is not clear how the authors judged bleeding as successfully stopped, what is the parameter
(s) used or that?
- Any predictors of efficacy in omeprazole treated group
- What is the rationale behind improved stress markers in omeprazole group
B- In manuscript writing:
- Please define some abbreviations on its first use
- Please check the attached word file for further comments
assistant