Title: Higher relative fat mass was associated with a higher prevalence of gallstones in US adults
Version: 2 Date: 02 Feb 2025
Reviewer's report:
In this manuscript entitled “Higher relative fat mass was associated with a higher prevalence of
gallstones in US adults”, the authors examined the association between relative fat mass (RFM)
and gallstone. Although this is an interesting topic, there are several points which should be
clarified in the current paper.
1. The RFM is not a simple score to calculate. The authors should explain the clinical rationale
of this study.
2. Although the RFM was superior to BMI, the AUC was not strong enough as a marker (<0.7)
3. The authors should explain the reference article of RFM in the method section.
4. This study shows better ability to identify gallstone than the present work (PMID: 39881275).
The authors should compare and make a discussion.
5. Body fat accumulation is also associated with steatotic liver disease. The authors should
compare and make a discussion (PMID: 37143429).
Title: Higher relative fat mass was associated with a higher prevalence of gallstones in US adults
Version: 2 Date: 02 Feb 2025
Reviewer's report:
In this manuscript entitled “Higher relative fat mass was associated with a higher prevalence of
gallstones in US adults”, the authors examined the association between relative fat mass (RFM)
and gallstone. Although this is an interesting topic, there are several points which should be
clarified in the current paper.
1. The RFM is not a simple score to calculate. The authors should explain the clinical rationale
of this study.
2. Although the RFM was superior to BMI, the AUC was not strong enough as a marker (<0.7)
3. The authors should explain the reference article of RFM in the method section.
4. This study shows better ability to identify gallstone than the present work (PMID: 39881275).
The authors should compare and make a discussion.
5. Body fat accumulation is also associated with steatotic liver disease. The authors should
compare and make a discussion (PMID: 37143429).
Please review this paper.
user
Title: Higher relative fat mass was associated with a higher prevalence of gallstones in US adults
Version: 2 Date: 02 Feb 2025
Reviewer's report:
In this manuscript entitled “Higher relative fat mass was associated with a higher prevalence of
gallstones in US adults”, the authors examined the association between relative fat mass (RFM)
and gallstone. Although this is an interesting topic, there are several points which should be
clarified in the current paper.
1. The RFM is not a simple score to calculate. The authors should explain the clinical rationale
of this study.
2. Although the RFM was superior to BMI, the AUC was not strong enough as a marker (<0.7)
3. The authors should explain the reference article of RFM in the method section.
4. This study shows better ability to identify gallstone than the present work (PMID: 39881275).
The authors should compare and make a discussion.
5. Body fat accumulation is also associated with steatotic liver disease. The authors should
compare and make a discussion (PMID: 37143429).
assistant