Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 2 Date: 08 Jul 2022
Reviewer's report:
I would like to congratulate the authors on discussing a very pertinent  topic . However going
through the article , I would like to offer a few comments
1. The topic is increasingly been discussed with a number of prediction models already being
published including those from regions with  high TB incidence
2. Therefore the introduction need to be edited to highlight the importance of this study citing
relevant stats: What is the statistics of TB and Crohn's in your region and how does it differ from
rest of the world including the developing world
3. You have cited studies with small sample size.  However, your study suffers from the same
drawback: 133 patients (CD 90 and ITB 43)
4. You have added the histological appearance of granuloma into your  nomogram(37.2% of
patients with ITB and in 16.7% of patients with CD (P =0.009) . Curiously caseation necrosis
has not been found to be clinically significant. Is the appearance of only granuloma i.e, in the
absence of caseation necrosis  a confounding variable?
5. The discussion is pertinent to the results but may be edited
6. Lastly mistakes in grammar and syntax may be improved in consultation with a native English
language expert.
Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 2 Date: 08 Jul 2022
Reviewer's report:
I would like to congratulate the authors on discussing a very pertinent  topic . However going
through the article , I would like to offer a few comments
1. The topic is increasingly been discussed with a number of prediction models already being
published including those from regions with  high TB incidence
2. Therefore the introduction need to be edited to highlight the importance of this study citing
relevant stats: What is the statistics of TB and Crohn's in your region and how does it differ from
rest of the world including the developing world
3. You have cited studies with small sample size.  However, your study suffers from the same
drawback: 133 patients (CD 90 and ITB 43)
4. You have added the histological appearance of granuloma into your  nomogram(37.2% of
patients with ITB and in 16.7% of patients with CD (P =0.009) . Curiously caseation necrosis
has not been found to be clinically significant. Is the appearance of only granuloma i.e, in the
absence of caseation necrosis  a confounding variable?
5. The discussion is pertinent to the results but may be edited
6. Lastly mistakes in grammar and syntax may be improved in consultation with a native English
language expert.
Please review this paper.
user
Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 2 Date: 08 Jul 2022
Reviewer's report:
I would like to congratulate the authors on discussing a very pertinent  topic . However going
through the article , I would like to offer a few comments
1. The topic is increasingly been discussed with a number of prediction models already being
published including those from regions with  high TB incidence
2. Therefore the introduction need to be edited to highlight the importance of this study citing
relevant stats: What is the statistics of TB and Crohn's in your region and how does it differ from
rest of the world including the developing world
3. You have cited studies with small sample size.  However, your study suffers from the same
drawback: 133 patients (CD 90 and ITB 43)
4. You have added the histological appearance of granuloma into your  nomogram(37.2% of
patients with ITB and in 16.7% of patients with CD (P =0.009) . Curiously caseation necrosis
has not been found to be clinically significant. Is the appearance of only granuloma i.e, in the
absence of caseation necrosis  a confounding variable?
5. The discussion is pertinent to the results but may be edited
6. Lastly mistakes in grammar and syntax may be improved in consultation with a native English
language expert.
assistant