Title: A nomogram for predicting survival in patients with advanced (stage III/IV) pancreatic
body tail cancer: A SEER-based study
Version: 1 Date: 29 Apr 2022
Reviewer's report:
The authors investigated a predictive nomogram based on SEER database for PBTC survival.
There are several comments to be addressed.
1. In page 5 line 12-13, the authors mentioned that they used AJCC 7th TMN stage in this study.
AJCC 8th could predicted the prognosis more precisely than AJCC 7th, So why not the authors
manually adjusted to AJCC 8th in this study?
2. In Table.2, it is confused that N stage and chemotherapy had no effect on survival in univariate
analysis, but they were independent factors after multivariate analysis. It is unclear that this
is caused by other confounding factors in or multi-collinearity factors. Multi-collinearity bias
should be excluded before multivariate analysis.
3. It would be better to enrolled another external validation cohort (non-American patient cohort
would be better) to validate the predictive value.
Title: A nomogram for predicting survival in patients with advanced (stage III/IV) pancreatic
body tail cancer: A SEER-based study
Version: 1 Date: 29 Apr 2022
Reviewer's report:
The authors investigated a predictive nomogram based on SEER database for PBTC survival.
There are several comments to be addressed.
1. In page 5 line 12-13, the authors mentioned that they used AJCC 7th TMN stage in this study.
AJCC 8th could predicted the prognosis more precisely than AJCC 7th, So why not the authors
manually adjusted to AJCC 8th in this study?
2. In Table.2, it is confused that N stage and chemotherapy had no effect on survival in univariate
analysis, but they were independent factors after multivariate analysis. It is unclear that this
is caused by other confounding factors in or multi-collinearity factors. Multi-collinearity bias
should be excluded before multivariate analysis.
3. It would be better to enrolled another external validation cohort (non-American patient cohort
would be better) to validate the predictive value.
Please review this paper.
user
Title: A nomogram for predicting survival in patients with advanced (stage III/IV) pancreatic
body tail cancer: A SEER-based study
Version: 1 Date: 29 Apr 2022
Reviewer's report:
The authors investigated a predictive nomogram based on SEER database for PBTC survival.
There are several comments to be addressed.
1. In page 5 line 12-13, the authors mentioned that they used AJCC 7th TMN stage in this study.
AJCC 8th could predicted the prognosis more precisely than AJCC 7th, So why not the authors
manually adjusted to AJCC 8th in this study?
2. In Table.2, it is confused that N stage and chemotherapy had no effect on survival in univariate
analysis, but they were independent factors after multivariate analysis. It is unclear that this
is caused by other confounding factors in or multi-collinearity factors. Multi-collinearity bias
should be excluded before multivariate analysis.
3. It would be better to enrolled another external validation cohort (non-American patient cohort
would be better) to validate the predictive value.
assistant