Reviewer ’s report  
 
Title:  Relationship of Body Weigh t with Gastrointestinal Motor and Sensory Function: Studies 
in Anorexia Nervosa and Obesity  
 
Version: 0 Date:  05 Aug 2016 
 
Reviewer:  Sanja Klobucar  Majanovic  
 
Reviewer’s report:  
 
The authors have completed a comprehensive research focusing on the relationship of body 
weight with gastrointestonal motor and sensory function. They assessed postprandial 
gastrointestinal function and sensations of satiation across a wide range o f body weight and after 
weight change. Results indicate that gastric emptying rate is decreased and postprandial 
sensations of satiation are increased in anorexia nervosa patients compared to normal weight and 
overweight patients. These findings support th e authors  hypothesis that the physiological 
response to feeding is more pronounced in individuals with lower body weight and suggest that 
the differences in gastrointestinal motor and sensory function is unlikely to be a primary cause of 
underweight or ob esity. The article is well -organized, it contains all of the necessary 
components. Metodology is clearly explained and article is well -written and easy to understand. 
However, the results would have been even more important if more patients especially obes e, 
were included in the study as well as obese patients who managed to lose >5% of body weight.  
 
In the Abstract (line 43 and 46) space between parenthesis and kg/m2 is needed.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you rec ommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication o f this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied  for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I h ave no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I ha ve no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published . 
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title:  Relationship of Body Weigh t with Gastrointestinal Motor and Sensory Function: Studies 
in Anorexia Nervosa and Obesity  
 
Version: 0 Date:  05 Aug 2016 
 
Reviewer:  Sanja Klobucar  Majanovic  
 
Reviewer’s report:  
 
The authors have completed a comprehensive research focusing on the relationship of body 
weight with gastrointestonal motor and sensory function. They assessed postprandial 
gastrointestinal function and sensations of satiation across a wide range o f body weight and after 
weight change. Results indicate that gastric emptying rate is decreased and postprandial 
sensations of satiation are increased in anorexia nervosa patients compared to normal weight and 
overweight patients. These findings support th e authors  hypothesis that the physiological 
response to feeding is more pronounced in individuals with lower body weight and suggest that 
the differences in gastrointestinal motor and sensory function is unlikely to be a primary cause of 
underweight or ob esity. The article is well -organized, it contains all of the necessary 
components. Metodology is clearly explained and article is well -written and easy to understand. 
However, the results would have been even more important if more patients especially obes e, 
were included in the study as well as obese patients who managed to lose >5% of body weight.  
 
In the Abstract (line 43 and 46) space between parenthesis and kg/m2 is needed.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you rec ommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication o f this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied  for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I h ave no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I ha ve no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published . 
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title:  Relationship of Body Weigh t with Gastrointestinal Motor and Sensory Function: Studies 
in Anorexia Nervosa and Obesity  
 
Version: 0 Date:  05 Aug 2016 
 
Reviewer:  Sanja Klobucar  Majanovic  
 
Reviewer’s report:  
 
The authors have completed a comprehensive research focusing on the relationship of body 
weight with gastrointestonal motor and sensory function. They assessed postprandial 
gastrointestinal function and sensations of satiation across a wide range o f body weight and after 
weight change. Results indicate that gastric emptying rate is decreased and postprandial 
sensations of satiation are increased in anorexia nervosa patients compared to normal weight and 
overweight patients. These findings support th e authors  hypothesis that the physiological 
response to feeding is more pronounced in individuals with lower body weight and suggest that 
the differences in gastrointestinal motor and sensory function is unlikely to be a primary cause of 
underweight or ob esity. The article is well -organized, it contains all of the necessary 
components. Metodology is clearly explained and article is well -written and easy to understand. 
However, the results would have been even more important if more patients especially obes e, 
were included in the study as well as obese patients who managed to lose >5% of body weight.  
 
In the Abstract (line 43 and 46) space between parenthesis and kg/m2 is needed.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls ar e required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you rec ommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication o f this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied  for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I h ave no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I ha ve no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published . 
 
I agree to the open peer review policy of the journal  
assistant