Title: Normal values for high-resolution anorectal manometry in healthy young adults: Evidence
from Vietnam
Version: 1 Date: 05 Apr 2021
Reviewer's report:
This study establishes normal values of HRAM in young healthy adults in Vietnam, and in
particular, examine the influence of sex on various outcomes. The Design of case studies
is statistically sounding. The Method/Results are fairly explained. The Discussion are well
conducted, including comparison with literature and reasoning from physiology. The limitation
on sample size and constraint of single center is also well addressed.
I have two recommendations for a minor revision.
1) Method section: It is helpful to clearly explain how to derive/calculate below outcomes
from HRAM:  maximum resting pressure, maximum squeezing pressure, maximum coughing
pressure, and maximum strain pressure values. Optionally, one can cite related literature that
gives details on those calculations.
2) Result section: As HRMA consists of eight-channel sensors, illustration on (temporal-)spatial
variations among those 8-channel pressure data could provide more physiological information.
Hence, two pressure figure/topography, one for a male and the other for a female subject, may
help the reader to appreciate the difference.
Title: Normal values for high-resolution anorectal manometry in healthy young adults: Evidence
from Vietnam
Version: 1 Date: 05 Apr 2021
Reviewer's report:
This study establishes normal values of HRAM in young healthy adults in Vietnam, and in
particular, examine the influence of sex on various outcomes. The Design of case studies
is statistically sounding. The Method/Results are fairly explained. The Discussion are well
conducted, including comparison with literature and reasoning from physiology. The limitation
on sample size and constraint of single center is also well addressed.
I have two recommendations for a minor revision.
1) Method section: It is helpful to clearly explain how to derive/calculate below outcomes
from HRAM:  maximum resting pressure, maximum squeezing pressure, maximum coughing
pressure, and maximum strain pressure values. Optionally, one can cite related literature that
gives details on those calculations.
2) Result section: As HRMA consists of eight-channel sensors, illustration on (temporal-)spatial
variations among those 8-channel pressure data could provide more physiological information.
Hence, two pressure figure/topography, one for a male and the other for a female subject, may
help the reader to appreciate the difference.
Please review this paper.
user
Title: Normal values for high-resolution anorectal manometry in healthy young adults: Evidence
from Vietnam
Version: 1 Date: 05 Apr 2021
Reviewer's report:
This study establishes normal values of HRAM in young healthy adults in Vietnam, and in
particular, examine the influence of sex on various outcomes. The Design of case studies
is statistically sounding. The Method/Results are fairly explained. The Discussion are well
conducted, including comparison with literature and reasoning from physiology. The limitation
on sample size and constraint of single center is also well addressed.
I have two recommendations for a minor revision.
1) Method section: It is helpful to clearly explain how to derive/calculate below outcomes
from HRAM:  maximum resting pressure, maximum squeezing pressure, maximum coughing
pressure, and maximum strain pressure values. Optionally, one can cite related literature that
gives details on those calculations.
2) Result section: As HRMA consists of eight-channel sensors, illustration on (temporal-)spatial
variations among those 8-channel pressure data could provide more physiological information.
Hence, two pressure figure/topography, one for a male and the other for a female subject, may
help the reader to appreciate the difference.
assistant