Title: Vitamin B6 ameliorates acute pancreatitis by suppressing the Caspase3 signaling pathway
Version: 1 Date: 05 Dec 2023
Reviewer's report:
The authors have performed an excellent study, well designed with a potential direct application
in the preclinical drug discovery for pancreatitis. The manuscript can be accepted after revision.
1. Improvement of the grammar is required.
2. What is the clinical translation pathway for this treatment? Any trials planned? Write in
discussion section.
3. What are the limitations of this study? Write in discussion section.
4. As it is vitamin, I suggest the authors should comment on the pharmacokinetic problems.
5. The quality of the figures is low. The resolution should be improved.
Title: Vitamin B6 ameliorates acute pancreatitis by suppressing the Caspase3 signaling pathway
Version: 1 Date: 05 Dec 2023
Reviewer's report:
The authors have performed an excellent study, well designed with a potential direct application
in the preclinical drug discovery for pancreatitis. The manuscript can be accepted after revision.
1. Improvement of the grammar is required.
2. What is the clinical translation pathway for this treatment? Any trials planned? Write in
discussion section.
3. What are the limitations of this study? Write in discussion section.
4. As it is vitamin, I suggest the authors should comment on the pharmacokinetic problems.
5. The quality of the figures is low. The resolution should be improved.
Please review this paper.
user
Title: Vitamin B6 ameliorates acute pancreatitis by suppressing the Caspase3 signaling pathway
Version: 1 Date: 05 Dec 2023
Reviewer's report:
The authors have performed an excellent study, well designed with a potential direct application
in the preclinical drug discovery for pancreatitis. The manuscript can be accepted after revision.
1. Improvement of the grammar is required.
2. What is the clinical translation pathway for this treatment? Any trials planned? Write in
discussion section.
3. What are the limitations of this study? Write in discussion section.
4. As it is vitamin, I suggest the authors should comment on the pharmacokinetic problems.
5. The quality of the figures is low. The resolution should be improved.
assistant