Reviewer's report
Title:Antiulcer activity of fluvoxamine in rats and its effect on oxidant and
antioxidant parameters in stomach tissue
Version: 3Date:31 March 2009
Reviewer: Jonathan Kaunitz
Reviewer's report:
General:
The authors resubmitted a manuscript in which they report that the compound
fluvoxamine, clinically used as an antidepressant, at high doses impairs gastric
ulceration in a standard indomethacin rat model.
The authors have conducted new studies in order to address concerns raised in
the critiques.
Major Compulsory Revisions:
Please provide more details regarding the GSH, NO, MPO, and MDA assays.
Simply stating that the samples were "sent to a biochemistry laboratory" was no
adequate.
Minor Essential Revisions:
Please explain abbreviations: LSD, MAO-B, GIS, etc.
Please use consistent spelling e.g. fluvoxamine, leukotriene, polymorph
Discretionary Revisions: None
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Antiulcer activity of fluvoxamine in rats and its effect on oxidant and
antioxidant parameters in stomach tissue
Version: 3Date:31 March 2009
Reviewer: Jonathan Kaunitz
Reviewer's report:
General:
The authors resubmitted a manuscript in which they report that the compound
fluvoxamine, clinically used as an antidepressant, at high doses impairs gastric
ulceration in a standard indomethacin rat model.
The authors have conducted new studies in order to address concerns raised in
the critiques.
Major Compulsory Revisions:
Please provide more details regarding the GSH, NO, MPO, and MDA assays.
Simply stating that the samples were "sent to a biochemistry laboratory" was no
adequate.
Minor Essential Revisions:
Please explain abbreviations: LSD, MAO-B, GIS, etc.
Please use consistent spelling e.g. fluvoxamine, leukotriene, polymorph
Discretionary Revisions: None
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Antiulcer activity of fluvoxamine in rats and its effect on oxidant and
antioxidant parameters in stomach tissue
Version: 3Date:31 March 2009
Reviewer: Jonathan Kaunitz
Reviewer's report:
General:
The authors resubmitted a manuscript in which they report that the compound
fluvoxamine, clinically used as an antidepressant, at high doses impairs gastric
ulceration in a standard indomethacin rat model.
The authors have conducted new studies in order to address concerns raised in
the critiques.
Major Compulsory Revisions:
Please provide more details regarding the GSH, NO, MPO, and MDA assays.
Simply stating that the samples were "sent to a biochemistry laboratory" was no
adequate.
Minor Essential Revisions:
Please explain abbreviations: LSD, MAO-B, GIS, etc.
Please use consistent spelling e.g. fluvoxamine, leukotriene, polymorph
Discretionary Revisions: None
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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