Title: Identification of a vascular invasion-related signature based on lncRNA pairs for
predicting prognosis in hepatocellular carcinoma
Version: 5 Date: 14 Sep 2023
Reviewer's report:
In this article, authors present the concept of “DElncRNA pairs”, which is special, but we have
some questions about this concept.
1. The expression of a single gene is a continuous variable, which has different levels. Do your
DElncRNA pairs mask a lot of information by using only 0 and 1 to represent the expression of
lncRNA? Is this a common usage and has it been used in other literature?
2. In Suppl Table 4, 14 lncRNAs were identified as DElncRNAs associatied with prognosis
and all of these 14 DElncRNAs were upregulated. But the gene pairs formed between them are
protective factors for prognosis, such as AC048341.2|LENG8-AS1, AC048341.2|GIHCG. How
do you explain this result and do you think it is reasonable?
3. How are the immune components of C1-C6 identified. This needs to be explained in the
Materials and methods.
Title: Identification of a vascular invasion-related signature based on lncRNA pairs for
predicting prognosis in hepatocellular carcinoma
Version: 5 Date: 14 Sep 2023
Reviewer's report:
In this article, authors present the concept of “DElncRNA pairs”, which is special, but we have
some questions about this concept.
1. The expression of a single gene is a continuous variable, which has different levels. Do your
DElncRNA pairs mask a lot of information by using only 0 and 1 to represent the expression of
lncRNA? Is this a common usage and has it been used in other literature?
2. In Suppl Table 4, 14 lncRNAs were identified as DElncRNAs associatied with prognosis
and all of these 14 DElncRNAs were upregulated. But the gene pairs formed between them are
protective factors for prognosis, such as AC048341.2|LENG8-AS1, AC048341.2|GIHCG. How
do you explain this result and do you think it is reasonable?
3. How are the immune components of C1-C6 identified. This needs to be explained in the
Materials and methods.
Please review this paper.
user
Title: Identification of a vascular invasion-related signature based on lncRNA pairs for
predicting prognosis in hepatocellular carcinoma
Version: 5 Date: 14 Sep 2023
Reviewer's report:
In this article, authors present the concept of “DElncRNA pairs”, which is special, but we have
some questions about this concept.
1. The expression of a single gene is a continuous variable, which has different levels. Do your
DElncRNA pairs mask a lot of information by using only 0 and 1 to represent the expression of
lncRNA? Is this a common usage and has it been used in other literature?
2. In Suppl Table 4, 14 lncRNAs were identified as DElncRNAs associatied with prognosis
and all of these 14 DElncRNAs were upregulated. But the gene pairs formed between them are
protective factors for prognosis, such as AC048341.2|LENG8-AS1, AC048341.2|GIHCG. How
do you explain this result and do you think it is reasonable?
3. How are the immune components of C1-C6 identified. This needs to be explained in the
Materials and methods.
assistant