Title: Prognostic Factors and Adjuvant Chemotherapy Efficacy in Stage I Gastric Cancer
Patients: A Retrospective Analysis
Version: 2 Date: 24 Nov 2024
Reviewer's report:
This is a retrospective clinical sudy regarding stage I gastric cancer. Authors would like to
investigate possible prognostic factors as well as to evaluate adjuvant chemotherapy efficacy
in stage I gastric cancer patients. For this purpose they retrospectively analyses 902 patients
data regarding recurrence, mortality, TNM status, effect of chemotherapy etc. According to this
analyses they found 3 independent risk factors ( age #65 years, pT2 stage, and tumor diameter
#5 cm) for recurrence or mortality. They also found that adjuvant chemotherapy has no survival
benefit and could adversely affect stage I gastric cancer patients without risk factors.
The study is well designed and well written. Hypothesis is solid, introduction section is clear
and understantable. Patients and method section has enough information for study population,
surgical treatment methods,statistical analyses. Results are objectively explains with good
graphics and tables. Results are scientifically discusses and compares with current literature in
discussion section.
Overall I would say publication of this study is going to be important contribution to the
literature.
Title: Prognostic Factors and Adjuvant Chemotherapy Efficacy in Stage I Gastric Cancer
Patients: A Retrospective Analysis
Version: 2 Date: 24 Nov 2024
Reviewer's report:
This is a retrospective clinical sudy regarding stage I gastric cancer. Authors would like to
investigate possible prognostic factors as well as to evaluate adjuvant chemotherapy efficacy
in stage I gastric cancer patients. For this purpose they retrospectively analyses 902 patients
data regarding recurrence, mortality, TNM status, effect of chemotherapy etc. According to this
analyses they found 3 independent risk factors ( age #65 years, pT2 stage, and tumor diameter
#5 cm) for recurrence or mortality. They also found that adjuvant chemotherapy has no survival
benefit and could adversely affect stage I gastric cancer patients without risk factors.
The study is well designed and well written. Hypothesis is solid, introduction section is clear
and understantable. Patients and method section has enough information for study population,
surgical treatment methods,statistical analyses. Results are objectively explains with good
graphics and tables. Results are scientifically discusses and compares with current literature in
discussion section.
Overall I would say publication of this study is going to be important contribution to the
literature.
Please review this paper.
user
Title: Prognostic Factors and Adjuvant Chemotherapy Efficacy in Stage I Gastric Cancer
Patients: A Retrospective Analysis
Version: 2 Date: 24 Nov 2024
Reviewer's report:
This is a retrospective clinical sudy regarding stage I gastric cancer. Authors would like to
investigate possible prognostic factors as well as to evaluate adjuvant chemotherapy efficacy
in stage I gastric cancer patients. For this purpose they retrospectively analyses 902 patients
data regarding recurrence, mortality, TNM status, effect of chemotherapy etc. According to this
analyses they found 3 independent risk factors ( age #65 years, pT2 stage, and tumor diameter
#5 cm) for recurrence or mortality. They also found that adjuvant chemotherapy has no survival
benefit and could adversely affect stage I gastric cancer patients without risk factors.
The study is well designed and well written. Hypothesis is solid, introduction section is clear
and understantable. Patients and method section has enough information for study population,
surgical treatment methods,statistical analyses. Results are objectively explains with good
graphics and tables. Results are scientifically discusses and compares with current literature in
discussion section.
Overall I would say publication of this study is going to be important contribution to the
literature.
assistant