Title: Efficacy and safety of Bifidobacterium quadruple viable tablets combined with mosapride
citrate in the treatment of constipation in China: A systematic review and meta-analysis
Version: 1 Date: 20 Mar 2023
Reviewer's report:
This is a systematic review and meta-analysis of the comparison of mosapride plus Probiotic
with mosapride alone. There are a few suggestions for the improvement of the article below:
1. Please delete “13 studies were included”, either from the methods or results section of the
abstract
2. Please make the conclusion in the abstract more succinct.
3. In the opening paragraph of your introduction, please define chronic idiopathic constipation
as per ROME criteria.
4. “Prolonged duration of FC can cause hemorrhoids, increase the risk of cardiovascular disease
and bowel cancer, lead to negative emotions such as anxiety and depression, and seriously affect
the quality of life of patients”. Please provide appropriate evidence to support this sentence,
especially the increased risk of CV disease and colon cancer.
5. What does “traditional treatment” mean? Do you mean the standard of care? If yes, fiber and
osmotic laxatives are the first lines of treatment. Please correct accordingly
6. There are multiple grammatical and language errors that need to be corrected throughout the
manuscript. Extensive revision is needed
7. The search strategy had very limited words. Why was the word “astriction” part of the
search strategy? Please revise the search strategy and add PRISMA-S to the manuscript as a
supplementary document
8. Please add the PRISMA checklist to the document
9. The search strategy mentions that all retrospective and prospective studies were included
while the inclusion criteria suggest that only RCTs were included. Please correct this.
10. The discussion is not streamlined, and it is hard for the reader to follow what the authors are
trying to convey. I would recommend rewriting the discussion and discussing your results and
their impact on managing this condition.
Title: Efficacy and safety of Bifidobacterium quadruple viable tablets combined with mosapride
citrate in the treatment of constipation in China: A systematic review and meta-analysis
Version: 1 Date: 20 Mar 2023
Reviewer's report:
This is a systematic review and meta-analysis of the comparison of mosapride plus Probiotic
with mosapride alone. There are a few suggestions for the improvement of the article below:
1. Please delete “13 studies were included”, either from the methods or results section of the
abstract
2. Please make the conclusion in the abstract more succinct.
3. In the opening paragraph of your introduction, please define chronic idiopathic constipation
as per ROME criteria.
4. “Prolonged duration of FC can cause hemorrhoids, increase the risk of cardiovascular disease
and bowel cancer, lead to negative emotions such as anxiety and depression, and seriously affect
the quality of life of patients”. Please provide appropriate evidence to support this sentence,
especially the increased risk of CV disease and colon cancer.
5. What does “traditional treatment” mean? Do you mean the standard of care? If yes, fiber and
osmotic laxatives are the first lines of treatment. Please correct accordingly
6. There are multiple grammatical and language errors that need to be corrected throughout the
manuscript. Extensive revision is needed
7. The search strategy had very limited words. Why was the word “astriction” part of the
search strategy? Please revise the search strategy and add PRISMA-S to the manuscript as a
supplementary document
8. Please add the PRISMA checklist to the document
9. The search strategy mentions that all retrospective and prospective studies were included
while the inclusion criteria suggest that only RCTs were included. Please correct this.
10. The discussion is not streamlined, and it is hard for the reader to follow what the authors are
trying to convey. I would recommend rewriting the discussion and discussing your results and
their impact on managing this condition.
Please review this paper.
user
Title: Efficacy and safety of Bifidobacterium quadruple viable tablets combined with mosapride
citrate in the treatment of constipation in China: A systematic review and meta-analysis
Version: 1 Date: 20 Mar 2023
Reviewer's report:
This is a systematic review and meta-analysis of the comparison of mosapride plus Probiotic
with mosapride alone. There are a few suggestions for the improvement of the article below:
1. Please delete “13 studies were included”, either from the methods or results section of the
abstract
2. Please make the conclusion in the abstract more succinct.
3. In the opening paragraph of your introduction, please define chronic idiopathic constipation
as per ROME criteria.
4. “Prolonged duration of FC can cause hemorrhoids, increase the risk of cardiovascular disease
and bowel cancer, lead to negative emotions such as anxiety and depression, and seriously affect
the quality of life of patients”. Please provide appropriate evidence to support this sentence,
especially the increased risk of CV disease and colon cancer.
5. What does “traditional treatment” mean? Do you mean the standard of care? If yes, fiber and
osmotic laxatives are the first lines of treatment. Please correct accordingly
6. There are multiple grammatical and language errors that need to be corrected throughout the
manuscript. Extensive revision is needed
7. The search strategy had very limited words. Why was the word “astriction” part of the
search strategy? Please revise the search strategy and add PRISMA-S to the manuscript as a
supplementary document
8. Please add the PRISMA checklist to the document
9. The search strategy mentions that all retrospective and prospective studies were included
while the inclusion criteria suggest that only RCTs were included. Please correct this.
10. The discussion is not streamlined, and it is hard for the reader to follow what the authors are
trying to convey. I would recommend rewriting the discussion and discussing your results and
their impact on managing this condition.
assistant