Reviewer's report
Title:The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux
Disease
Version: 6Date:8 December 2009
Reviewer: Stanis&#322;aw Konturek
Reviewer's report:
The revised paper is much improved in comparison with original manuscript as
the gastric acid and serum gastrin data have been corporated. The measurement
of gastrin by RIA requires more details regarding the reproducibility and accuracy
of the gastrin assay as well as the gastrin antibodies used. Originally, I also
requested to insert the data with histological evaluation of the esophageal
mucosa in patients with GERD before and after treatment with melatonin, PPI or
their combination, but now I would drop out this request. I foud numerous English
errors in the text which have to be taken care before the publication of the paper.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interest below.
Reviewer's report
Title:The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux
Disease
Version: 6Date:8 December 2009
Reviewer: Stanis&#322;aw Konturek
Reviewer's report:
The revised paper is much improved in comparison with original manuscript as
the gastric acid and serum gastrin data have been corporated. The measurement
of gastrin by RIA requires more details regarding the reproducibility and accuracy
of the gastrin assay as well as the gastrin antibodies used. Originally, I also
requested to insert the data with histological evaluation of the esophageal
mucosa in patients with GERD before and after treatment with melatonin, PPI or
their combination, but now I would drop out this request. I foud numerous English
errors in the text which have to be taken care before the publication of the paper.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interest below.
Please review this paper.
user
Reviewer's report
Title:The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux
Disease
Version: 6Date:8 December 2009
Reviewer: Stanis&#322;aw Konturek
Reviewer's report:
The revised paper is much improved in comparison with original manuscript as
the gastric acid and serum gastrin data have been corporated. The measurement
of gastrin by RIA requires more details regarding the reproducibility and accuracy
of the gastrin assay as well as the gastrin antibodies used. Originally, I also
requested to insert the data with histological evaluation of the esophageal
mucosa in patients with GERD before and after treatment with melatonin, PPI or
their combination, but now I would drop out this request. I foud numerous English
errors in the text which have to be taken care before the publication of the paper.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interest below.
assistant