Title: Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center
case series
Version: 3 Date: 09 Aug 2024
Reviewer's report:
This paper examines the clinical characteristics and endoscopic findings of PGA based on case
examples. The following points require careful consideration:
While there are commonalities in histological features and immunohistochemical staining
between PGA of the stomach and duodenum and that of the gallbladder, reports suggest that
they differ in genetic abnormalities and directions of cellular differentiation. These two entities
should be clearly distinguished, and analyzing them together seems challenging.
Since one of the aims of this paper, as indicated by its title, is to explore endoscopic
characteristics, the analysis should be limited to the stomach and duodenum, where endoscopic
findings can be observed.
Regarding gallbladder PGA, the discussion does not address it. To analyze it within a single
paper, it is necessary to include a discussion on gallbladder PGA as well. The conclusion omits
mention of the gallbladder.
Your consideration on these matters would be greatly appreciated.
Title: Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center
case series
Version: 3 Date: 09 Aug 2024
Reviewer's report:
This paper examines the clinical characteristics and endoscopic findings of PGA based on case
examples. The following points require careful consideration:
While there are commonalities in histological features and immunohistochemical staining
between PGA of the stomach and duodenum and that of the gallbladder, reports suggest that
they differ in genetic abnormalities and directions of cellular differentiation. These two entities
should be clearly distinguished, and analyzing them together seems challenging.
Since one of the aims of this paper, as indicated by its title, is to explore endoscopic
characteristics, the analysis should be limited to the stomach and duodenum, where endoscopic
findings can be observed.
Regarding gallbladder PGA, the discussion does not address it. To analyze it within a single
paper, it is necessary to include a discussion on gallbladder PGA as well. The conclusion omits
mention of the gallbladder.
Your consideration on these matters would be greatly appreciated.
Please review this paper.
user
Title: Clinicopathological characteristics of 30 cases of pyloric gland adenoma: a single center
case series
Version: 3 Date: 09 Aug 2024
Reviewer's report:
This paper examines the clinical characteristics and endoscopic findings of PGA based on case
examples. The following points require careful consideration:
While there are commonalities in histological features and immunohistochemical staining
between PGA of the stomach and duodenum and that of the gallbladder, reports suggest that
they differ in genetic abnormalities and directions of cellular differentiation. These two entities
should be clearly distinguished, and analyzing them together seems challenging.
Since one of the aims of this paper, as indicated by its title, is to explore endoscopic
characteristics, the analysis should be limited to the stomach and duodenum, where endoscopic
findings can be observed.
Regarding gallbladder PGA, the discussion does not address it. To analyze it within a single
paper, it is necessary to include a discussion on gallbladder PGA as well. The conclusion omits
mention of the gallbladder.
Your consideration on these matters would be greatly appreciated.
assistant