Title: IS CHEMODENERVATION WITH INCOBOTULINUMTOXINA AN
ALTERNATIVE TO INVASIVE CHRONIC ANAL FISSURE TREATMENTS?
Version: 4 Date: 18 Aug 2024
Reviewer:  Michele Schiano di Visconte
Reviewer's report:
The authors conducted insufficient review. One of the most important methodological errors is
not having identified the anal fissure according to Kennedy's classification (Kennedy ML, DCR
1992). This does not allow us to evaluate whether the withholding is effective. I don't think
a fourth degree fissure will heal with this treatment. The authors should therefore divide the
patients according to the severity of the clinical picture and then evaluate the results
Title: IS CHEMODENERVATION WITH INCOBOTULINUMTOXINA AN
ALTERNATIVE TO INVASIVE CHRONIC ANAL FISSURE TREATMENTS?
Version: 4 Date: 18 Aug 2024
Reviewer:  Michele Schiano di Visconte
Reviewer's report:
The authors conducted insufficient review. One of the most important methodological errors is
not having identified the anal fissure according to Kennedy's classification (Kennedy ML, DCR
1992). This does not allow us to evaluate whether the withholding is effective. I don't think
a fourth degree fissure will heal with this treatment. The authors should therefore divide the
patients according to the severity of the clinical picture and then evaluate the results
Please review this paper.
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Title: IS CHEMODENERVATION WITH INCOBOTULINUMTOXINA AN
ALTERNATIVE TO INVASIVE CHRONIC ANAL FISSURE TREATMENTS?
Version: 4 Date: 18 Aug 2024
Reviewer:  Michele Schiano di Visconte
Reviewer's report:
The authors conducted insufficient review. One of the most important methodological errors is
not having identified the anal fissure according to Kennedy's classification (Kennedy ML, DCR
1992). This does not allow us to evaluate whether the withholding is effective. I don't think
a fourth degree fissure will heal with this treatment. The authors should therefore divide the
patients according to the severity of the clinical picture and then evaluate the results
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