Reviewer's report
Title:Spontaneous remission of Crohn's disease following a febrile infection:
case report and literature review
Version: 1Date:29 March 2011
Reviewer: Marcel A Behr
Reviewer's report:
Major compulsory revisions:
The medical description of the case used some unclear terminology (e.g. twisting
of the bowel) and left out key information (what did the surgeon report when
doing the operation in mid-March and what did the pathology report state about
the excised material). The medical description needs to be edited by an MD
(potentially the patient's treating doctor) to ensure clarity and accuracy. The
time-line should be presented with dates, rather than late-February, mid-March,
etc. I do not understand the use of cephalexin for surgical prophylaxis beginning
3 weeks before surgery; normally peri-operative prophylaxis is
given...peri-operatively. Was the patient receiving this antibiotic for the treatment
of a proven/presumed active infection? What is meant by a flu-like infection?
What exact symptoms did the patient experience?
The scientific description started off as very interesting, placing this anecdote in
the context of the emerging literature that supports an innate immune deficiency
in Crohn's disease. However, the discussion was more about Ulcerative Colitis,
rather than Crohn's, which made for some confusion in interpreting the historical
literature. Given the immune-deficiency paradigm introduced by the authors, I
would want to know whether anyone has tried fever therapy for chronic
granulomatous disease (which shares pathology and anti-microbial antibodies
with Crohn's) or chronic variable immune deficiency (which also shares pathology
with Crohn's disease). Are there any case reports / case series of fever resulting
in clinical improvement of these established immunedeficiency states?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Spontaneous remission of Crohn's disease following a febrile infection:
case report and literature review
Version: 1Date:29 March 2011
Reviewer: Marcel A Behr
Reviewer's report:
Major compulsory revisions:
The medical description of the case used some unclear terminology (e.g. twisting
of the bowel) and left out key information (what did the surgeon report when
doing the operation in mid-March and what did the pathology report state about
the excised material). The medical description needs to be edited by an MD
(potentially the patient's treating doctor) to ensure clarity and accuracy. The
time-line should be presented with dates, rather than late-February, mid-March,
etc. I do not understand the use of cephalexin for surgical prophylaxis beginning
3 weeks before surgery; normally peri-operative prophylaxis is
given...peri-operatively. Was the patient receiving this antibiotic for the treatment
of a proven/presumed active infection? What is meant by a flu-like infection?
What exact symptoms did the patient experience?
The scientific description started off as very interesting, placing this anecdote in
the context of the emerging literature that supports an innate immune deficiency
in Crohn's disease. However, the discussion was more about Ulcerative Colitis,
rather than Crohn's, which made for some confusion in interpreting the historical
literature. Given the immune-deficiency paradigm introduced by the authors, I
would want to know whether anyone has tried fever therapy for chronic
granulomatous disease (which shares pathology and anti-microbial antibodies
with Crohn's) or chronic variable immune deficiency (which also shares pathology
with Crohn's disease). Are there any case reports / case series of fever resulting
in clinical improvement of these established immunedeficiency states?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Spontaneous remission of Crohn's disease following a febrile infection:
case report and literature review
Version: 1Date:29 March 2011
Reviewer: Marcel A Behr
Reviewer's report:
Major compulsory revisions:
The medical description of the case used some unclear terminology (e.g. twisting
of the bowel) and left out key information (what did the surgeon report when
doing the operation in mid-March and what did the pathology report state about
the excised material). The medical description needs to be edited by an MD
(potentially the patient's treating doctor) to ensure clarity and accuracy. The
time-line should be presented with dates, rather than late-February, mid-March,
etc. I do not understand the use of cephalexin for surgical prophylaxis beginning
3 weeks before surgery; normally peri-operative prophylaxis is
given...peri-operatively. Was the patient receiving this antibiotic for the treatment
of a proven/presumed active infection? What is meant by a flu-like infection?
What exact symptoms did the patient experience?
The scientific description started off as very interesting, placing this anecdote in
the context of the emerging literature that supports an innate immune deficiency
in Crohn's disease. However, the discussion was more about Ulcerative Colitis,
rather than Crohn's, which made for some confusion in interpreting the historical
literature. Given the immune-deficiency paradigm introduced by the authors, I
would want to know whether anyone has tried fever therapy for chronic
granulomatous disease (which shares pathology and anti-microbial antibodies
with Crohn's) or chronic variable immune deficiency (which also shares pathology
with Crohn's disease). Are there any case reports / case series of fever resulting
in clinical improvement of these established immunedeficiency states?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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