Reviewer's report
Title:Sphered cell subpopulations with cancer stem cell properties in human
hepatoma cell lines
Version: 2Date:3 May 2011
Reviewer: Malcolm Alison
Reviewer's report:
Minor essential revisions.
The authors appear to have responded positively to the referees comments, in
particular using a gamma secretase inhibitor to further implicate the Notch
pathway and increasing the number of drugs tested to which the sphere-forming
cells were more resistant. There is still a big problem with the English language
throughout e.g. tenses, 'CSCs is regarded'; starting sentences with 'And... and
the use of 'Sphered cells' throughout including the title - replace 'sphered cells'
with 'sphere-forming cells'.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests'
Reviewer's report
Title:Sphered cell subpopulations with cancer stem cell properties in human
hepatoma cell lines
Version: 2Date:3 May 2011
Reviewer: Malcolm Alison
Reviewer's report:
Minor essential revisions.
The authors appear to have responded positively to the referees comments, in
particular using a gamma secretase inhibitor to further implicate the Notch
pathway and increasing the number of drugs tested to which the sphere-forming
cells were more resistant. There is still a big problem with the English language
throughout e.g. tenses, 'CSCs is regarded'; starting sentences with 'And... and
the use of 'Sphered cells' throughout including the title - replace 'sphered cells'
with 'sphere-forming cells'.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Sphered cell subpopulations with cancer stem cell properties in human
hepatoma cell lines
Version: 2Date:3 May 2011
Reviewer: Malcolm Alison
Reviewer's report:
Minor essential revisions.
The authors appear to have responded positively to the referees comments, in
particular using a gamma secretase inhibitor to further implicate the Notch
pathway and increasing the number of drugs tested to which the sphere-forming
cells were more resistant. There is still a big problem with the English language
throughout e.g. tenses, 'CSCs is regarded'; starting sentences with 'And... and
the use of 'Sphered cells' throughout including the title - replace 'sphered cells'
with 'sphere-forming cells'.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests'
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