Reviewer's report
Title:Angiotensin II receptor expression and relation to Helicobacter
pylori-infection in stomach of the Mongolian gerbil
Version: 2Date:24 July 2009
Reviewer: Hiroto Miwa
Reviewer's report:
The authors described expression of angiotensin II receptors in the stomach was
described in this manuscript. They reported different expression of these
receptors according to SS1 and TN2GF4 H.pylori strain. They found levels of
Angiotensin II receptors expression correlates to PMN cells, yet
pathophysiological roles of this finding is unfortunately unclrear because their
study is basically observational.
1) Do only the PMN cells in the gastric wall express AT1R? Was the level of
expression of AT1R on PMNs different between PMNs in H.pylori infected gastric
mucosa and those in peripheral circulating blood? In other words, does AT1R in
PMNs in gastric epithelium have any specific physiological roles or just an
epi-phenomenon by infiltration of PMNs?
2) The discussion is tedious and too long.
3) P17, third sentence, “ Another finfdings…….” Such explanation of TN2GF4
bacteria possessing less AT1R is apparently overstated. The speculation “Taken
together…..” (p16, line 20) does not make sense to me either.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Angiotensin II receptor expression and relation to Helicobacter
pylori-infection in stomach of the Mongolian gerbil
Version: 2Date:24 July 2009
Reviewer: Hiroto Miwa
Reviewer's report:
The authors described expression of angiotensin II receptors in the stomach was
described in this manuscript. They reported different expression of these
receptors according to SS1 and TN2GF4 H.pylori strain. They found levels of
Angiotensin II receptors expression correlates to PMN cells, yet
pathophysiological roles of this finding is unfortunately unclrear because their
study is basically observational.
1) Do only the PMN cells in the gastric wall express AT1R? Was the level of
expression of AT1R on PMNs different between PMNs in H.pylori infected gastric
mucosa and those in peripheral circulating blood? In other words, does AT1R in
PMNs in gastric epithelium have any specific physiological roles or just an
epi-phenomenon by infiltration of PMNs?
2) The discussion is tedious and too long.
3) P17, third sentence, “ Another finfdings…….” Such explanation of TN2GF4
bacteria possessing less AT1R is apparently overstated. The speculation “Taken
together…..” (p16, line 20) does not make sense to me either.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Angiotensin II receptor expression and relation to Helicobacter
pylori-infection in stomach of the Mongolian gerbil
Version: 2Date:24 July 2009
Reviewer: Hiroto Miwa
Reviewer's report:
The authors described expression of angiotensin II receptors in the stomach was
described in this manuscript. They reported different expression of these
receptors according to SS1 and TN2GF4 H.pylori strain. They found levels of
Angiotensin II receptors expression correlates to PMN cells, yet
pathophysiological roles of this finding is unfortunately unclrear because their
study is basically observational.
1) Do only the PMN cells in the gastric wall express AT1R? Was the level of
expression of AT1R on PMNs different between PMNs in H.pylori infected gastric
mucosa and those in peripheral circulating blood? In other words, does AT1R in
PMNs in gastric epithelium have any specific physiological roles or just an
epi-phenomenon by infiltration of PMNs?
2) The discussion is tedious and too long.
3) P17, third sentence, “ Another finfdings…….” Such explanation of TN2GF4
bacteria possessing less AT1R is apparently overstated. The speculation “Taken
together…..” (p16, line 20) does not make sense to me either.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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