Title: Omeprazole taken once every other day can effectively prevent aspirin-induced
gastrointestinal mucosal damage in rats
Version: 3 Date: 29 Dec 2023
Reviewer's report:
(1) Due to the requirement of normality assumption for the application of the ANOVA test
and considering the small sample size (n=8) in this study, it is necessary to perform a Shapiro-
Wilk test beforehand to confirm the normal distribution. Alternatively, the ANOVA test may be
replaced with the Kruskal–Wallis test if the normality assumption is not met.
(2) The mechanism of proton pump inhibitors involves the inhibition of H-K-ATPase, the final
step in gastric acid secretion by parietal cells.  Please elucidate the plausible mechanism behind
the significantly higher cell proliferation ability observed in the Asp + Ome qd group compared
to both the Asp + Ome qod group and the Asp  group.
(3) Because successful eradication of H. pylori also improves the natural history of peptic ulcers,
please provide details on the Helicobacter pylori status (including whether eradication therapy
was administered) of the two patients enrolled in the study.
(4) Please provide the daily dosage of aspirin for two enrolled patients in the study.
(5) Due to the predominantly animal experimental result of this study and the limited human
trial involving only two patients, it is recommended to incorporate the phrase 'animal model'
into the study title.
Title: Omeprazole taken once every other day can effectively prevent aspirin-induced
gastrointestinal mucosal damage in rats
Version: 3 Date: 29 Dec 2023
Reviewer's report:
(1) Due to the requirement of normality assumption for the application of the ANOVA test
and considering the small sample size (n=8) in this study, it is necessary to perform a Shapiro-
Wilk test beforehand to confirm the normal distribution. Alternatively, the ANOVA test may be
replaced with the Kruskal–Wallis test if the normality assumption is not met.
(2) The mechanism of proton pump inhibitors involves the inhibition of H-K-ATPase, the final
step in gastric acid secretion by parietal cells.  Please elucidate the plausible mechanism behind
the significantly higher cell proliferation ability observed in the Asp + Ome qd group compared
to both the Asp + Ome qod group and the Asp  group.
(3) Because successful eradication of H. pylori also improves the natural history of peptic ulcers,
please provide details on the Helicobacter pylori status (including whether eradication therapy
was administered) of the two patients enrolled in the study.
(4) Please provide the daily dosage of aspirin for two enrolled patients in the study.
(5) Due to the predominantly animal experimental result of this study and the limited human
trial involving only two patients, it is recommended to incorporate the phrase 'animal model'
into the study title.
Please review this paper.
user
Title: Omeprazole taken once every other day can effectively prevent aspirin-induced
gastrointestinal mucosal damage in rats
Version: 3 Date: 29 Dec 2023
Reviewer's report:
(1) Due to the requirement of normality assumption for the application of the ANOVA test
and considering the small sample size (n=8) in this study, it is necessary to perform a Shapiro-
Wilk test beforehand to confirm the normal distribution. Alternatively, the ANOVA test may be
replaced with the Kruskal–Wallis test if the normality assumption is not met.
(2) The mechanism of proton pump inhibitors involves the inhibition of H-K-ATPase, the final
step in gastric acid secretion by parietal cells.  Please elucidate the plausible mechanism behind
the significantly higher cell proliferation ability observed in the Asp + Ome qd group compared
to both the Asp + Ome qod group and the Asp  group.
(3) Because successful eradication of H. pylori also improves the natural history of peptic ulcers,
please provide details on the Helicobacter pylori status (including whether eradication therapy
was administered) of the two patients enrolled in the study.
(4) Please provide the daily dosage of aspirin for two enrolled patients in the study.
(5) Due to the predominantly animal experimental result of this study and the limited human
trial involving only two patients, it is recommended to incorporate the phrase 'animal model'
into the study title.
assistant