Title: Health-care resource use and costs associated with inflammatory bowel disease in
northwest London: a retrospective linked database study
Version: 0 Date: 09 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Authors try to estimate direct costs of IBD Usually indirect costs like lost of productivity,
DALYs, obligatory leaves from work to transfer patients unable to be self supported, increase of
anxiety and depressive mood etc represent the bottom of the iceberg For those cost authors have
to give a hint since they have selected to talk about the top of the iceberg An interesting point
is only 5% of patients were initially treated with biologics Thus the percentage of patients with
early remission was very low Abstract The first sentence has little to do with IBD economics
and should be replaced with something closer to the theme More data could be presented apart
from a general overview for active disease Methods  Statistics Was there a need for advance
statistics to asimilate costs taking into consideration various comorbidities, disease activity and
demographics? Results Multivariated analysis would be more effective to define risk factors for
non-elective treatment or use of biologics The same might be valid for increase expenses
Title: Health-care resource use and costs associated with inflammatory bowel disease in
northwest London: a retrospective linked database study
Version: 0 Date: 09 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Authors try to estimate direct costs of IBD Usually indirect costs like lost of productivity,
DALYs, obligatory leaves from work to transfer patients unable to be self supported, increase of
anxiety and depressive mood etc represent the bottom of the iceberg For those cost authors have
to give a hint since they have selected to talk about the top of the iceberg An interesting point
is only 5% of patients were initially treated with biologics Thus the percentage of patients with
early remission was very low Abstract The first sentence has little to do with IBD economics
and should be replaced with something closer to the theme More data could be presented apart
from a general overview for active disease Methods  Statistics Was there a need for advance
statistics to asimilate costs taking into consideration various comorbidities, disease activity and
demographics? Results Multivariated analysis would be more effective to define risk factors for
non-elective treatment or use of biologics The same might be valid for increase expenses
Please review this paper.
user
Title: Health-care resource use and costs associated with inflammatory bowel disease in
northwest London: a retrospective linked database study
Version: 0 Date: 09 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Authors try to estimate direct costs of IBD Usually indirect costs like lost of productivity,
DALYs, obligatory leaves from work to transfer patients unable to be self supported, increase of
anxiety and depressive mood etc represent the bottom of the iceberg For those cost authors have
to give a hint since they have selected to talk about the top of the iceberg An interesting point
is only 5% of patients were initially treated with biologics Thus the percentage of patients with
early remission was very low Abstract The first sentence has little to do with IBD economics
and should be replaced with something closer to the theme More data could be presented apart
from a general overview for active disease Methods  Statistics Was there a need for advance
statistics to asimilate costs taking into consideration various comorbidities, disease activity and
demographics? Results Multivariated analysis would be more effective to define risk factors for
non-elective treatment or use of biologics The same might be valid for increase expenses
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