Title: Platelet-to-High-Density Lipoprotein Ratio (PHR) as a Predictive Biomarker for
Gastrointestinal Cancers: Evidence from NHANES
Version: 2 Date: 21 Mar 2025
Reviewer's report:
The revised manuscript addresses all major concerns raised in the initial review and significantly
improves the clarity, scientific rigor, and transparency of the study. The authors have
thoughtfully incorporated feedback, particularly regarding potential confounders, subgroup
interpretation, and limitations. The manuscript now provides a robust analysis of PHR
as a biomarker for gastrointestinal (GI) cancer risk, aligning with current literature and
clinical relevance. The study's strengths include its large, nationally representative dataset,
comprehensive covariate adjustments, and novel insights into systemic inflammation and lipid
metabolism. While minor limitations persist (e.g., cross-sectional design, lack of subtype-
specific analysis), these are appropriately acknowledged, and the findings remain compelling.
Overall, the manuscript is now ready for publication. The authors have addressed all reviewer
concerns effectively, and the revised work meets the journal's standards for scientific quality
and originality.
Title: Platelet-to-High-Density Lipoprotein Ratio (PHR) as a Predictive Biomarker for
Gastrointestinal Cancers: Evidence from NHANES
Version: 2 Date: 21 Mar 2025
Reviewer's report:
The revised manuscript addresses all major concerns raised in the initial review and significantly
improves the clarity, scientific rigor, and transparency of the study. The authors have
thoughtfully incorporated feedback, particularly regarding potential confounders, subgroup
interpretation, and limitations. The manuscript now provides a robust analysis of PHR
as a biomarker for gastrointestinal (GI) cancer risk, aligning with current literature and
clinical relevance. The study's strengths include its large, nationally representative dataset,
comprehensive covariate adjustments, and novel insights into systemic inflammation and lipid
metabolism. While minor limitations persist (e.g., cross-sectional design, lack of subtype-
specific analysis), these are appropriately acknowledged, and the findings remain compelling.
Overall, the manuscript is now ready for publication. The authors have addressed all reviewer
concerns effectively, and the revised work meets the journal's standards for scientific quality
and originality.
Please review this paper.
user
Title: Platelet-to-High-Density Lipoprotein Ratio (PHR) as a Predictive Biomarker for
Gastrointestinal Cancers: Evidence from NHANES
Version: 2 Date: 21 Mar 2025
Reviewer's report:
The revised manuscript addresses all major concerns raised in the initial review and significantly
improves the clarity, scientific rigor, and transparency of the study. The authors have
thoughtfully incorporated feedback, particularly regarding potential confounders, subgroup
interpretation, and limitations. The manuscript now provides a robust analysis of PHR
as a biomarker for gastrointestinal (GI) cancer risk, aligning with current literature and
clinical relevance. The study's strengths include its large, nationally representative dataset,
comprehensive covariate adjustments, and novel insights into systemic inflammation and lipid
metabolism. While minor limitations persist (e.g., cross-sectional design, lack of subtype-
specific analysis), these are appropriately acknowledged, and the findings remain compelling.
Overall, the manuscript is now ready for publication. The authors have addressed all reviewer
concerns effectively, and the revised work meets the journal's standards for scientific quality
and originality.
assistant