Title: Assessing the longitudinal association between the GGT/HDL-C ratio and NAFLD: a
cohort study in a non-obese Chinese population
Version: 0 Date: 11 Oct 2022
Reviewer's report:
In the study titled “Assessing the longitudinal association between the GGT/HDL-C ratio
and NAFLD: a cohort study in a non-obese Chinese population”, the authors have explored
the association between GGT/HDL-C ratio and the development of NAFLD in a cohort of
12,126 individuals over a follow-up period of 5 years. The authors found a positive association
between GGT/HDL-C ratio and NAFLD development. The association remained significant
after adjusting for numerous possible confounding factors. The authors also demonstrate that
the association between the GGT/HDL-C ratio and NAFLD is non-linear.
This is a well-written manuscript, and the data support the conclusions drawn in the study.
The present study provides a biomarker with possible clinical utility in predicting the incidence
of NAFLD. The authors have built upon the previous cross-sectional studies to provide a
piece of clinically relevant information. I have minor suggestions to improve the quality of the
manuscript.
Minor comments
1. The data set based on which the inferences are made in the present study is not accessible
using the link provided in the manuscript.
2. The utility of the GGT/HDL-C ratio in predicting the incidence of NAFLD in comparison to
the established risk factors like BMI needs to be discussed. This will help the readers to put the
utility of the GGT/HDL-C ratio in the clinical context.
3. It has been shown that predictive models with a combination of risk factors perform better
than any single variable in predicting the incidence of NAFLD. This needs to be discussed.
4. Though there are many predictive models for NAFLD, many of them are based on cross-
sectional data. Building a predictive model based on the longitudinal data would be a useful
exercise to better understand the contribution of various risk factors to the development of
NAFLD, though not necessary for the current manuscript.
Title: Assessing the longitudinal association between the GGT/HDL-C ratio and NAFLD: a
cohort study in a non-obese Chinese population
Version: 0 Date: 11 Oct 2022
Reviewer's report:
In the study titled “Assessing the longitudinal association between the GGT/HDL-C ratio
and NAFLD: a cohort study in a non-obese Chinese population”, the authors have explored
the association between GGT/HDL-C ratio and the development of NAFLD in a cohort of
12,126 individuals over a follow-up period of 5 years. The authors found a positive association
between GGT/HDL-C ratio and NAFLD development. The association remained significant
after adjusting for numerous possible confounding factors. The authors also demonstrate that
the association between the GGT/HDL-C ratio and NAFLD is non-linear.
This is a well-written manuscript, and the data support the conclusions drawn in the study.
The present study provides a biomarker with possible clinical utility in predicting the incidence
of NAFLD. The authors have built upon the previous cross-sectional studies to provide a
piece of clinically relevant information. I have minor suggestions to improve the quality of the
manuscript.
Minor comments
1. The data set based on which the inferences are made in the present study is not accessible
using the link provided in the manuscript.
2. The utility of the GGT/HDL-C ratio in predicting the incidence of NAFLD in comparison to
the established risk factors like BMI needs to be discussed. This will help the readers to put the
utility of the GGT/HDL-C ratio in the clinical context.
3. It has been shown that predictive models with a combination of risk factors perform better
than any single variable in predicting the incidence of NAFLD. This needs to be discussed.
4. Though there are many predictive models for NAFLD, many of them are based on cross-
sectional data. Building a predictive model based on the longitudinal data would be a useful
exercise to better understand the contribution of various risk factors to the development of
NAFLD, though not necessary for the current manuscript.
Please review this paper.
user
Title: Assessing the longitudinal association between the GGT/HDL-C ratio and NAFLD: a
cohort study in a non-obese Chinese population
Version: 0 Date: 11 Oct 2022
Reviewer's report:
In the study titled “Assessing the longitudinal association between the GGT/HDL-C ratio
and NAFLD: a cohort study in a non-obese Chinese population”, the authors have explored
the association between GGT/HDL-C ratio and the development of NAFLD in a cohort of
12,126 individuals over a follow-up period of 5 years. The authors found a positive association
between GGT/HDL-C ratio and NAFLD development. The association remained significant
after adjusting for numerous possible confounding factors. The authors also demonstrate that
the association between the GGT/HDL-C ratio and NAFLD is non-linear.
This is a well-written manuscript, and the data support the conclusions drawn in the study.
The present study provides a biomarker with possible clinical utility in predicting the incidence
of NAFLD. The authors have built upon the previous cross-sectional studies to provide a
piece of clinically relevant information. I have minor suggestions to improve the quality of the
manuscript.
Minor comments
1. The data set based on which the inferences are made in the present study is not accessible
using the link provided in the manuscript.
2. The utility of the GGT/HDL-C ratio in predicting the incidence of NAFLD in comparison to
the established risk factors like BMI needs to be discussed. This will help the readers to put the
utility of the GGT/HDL-C ratio in the clinical context.
3. It has been shown that predictive models with a combination of risk factors perform better
than any single variable in predicting the incidence of NAFLD. This needs to be discussed.
4. Though there are many predictive models for NAFLD, many of them are based on cross-
sectional data. Building a predictive model based on the longitudinal data would be a useful
exercise to better understand the contribution of various risk factors to the development of
NAFLD, though not necessary for the current manuscript.
assistant