Title: Efficacy and safety of tenofovir disoproxil fumarate versus entecavir in the treatment of
acute-on-chronic liver failure with hepatitis B: a systematic review and meta-analysis
Version: 3 Date: 18 Sep 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: In their present revised version, authors have correctly addressed
comments raised by reviewers. The Discussion is nicely presented, however, authors might
consider the following suggestions to improve their content :
REQUESTED REVISIONS:
Authors ended with only five eligible observational studies all from Asia. Given that HBV is
also highly prevalent in sub-Saharan Africa and to a less extent in South America, reports form
other regions should be supported.
In the conclusion, authors stated that TDF has a more pronounced effect on renal function during
long-term use than ETV. Given the small difference in found between TDF and ETV in eGRF
decrease (-5.83 vs -4.75 mL/min/1.73m2) I would mitigate the message that requires additional
studies."
Title: Efficacy and safety of tenofovir disoproxil fumarate versus entecavir in the treatment of
acute-on-chronic liver failure with hepatitis B: a systematic review and meta-analysis
Version: 3 Date: 18 Sep 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: In their present revised version, authors have correctly addressed
comments raised by reviewers. The Discussion is nicely presented, however, authors might
consider the following suggestions to improve their content :
REQUESTED REVISIONS:
Authors ended with only five eligible observational studies all from Asia. Given that HBV is
also highly prevalent in sub-Saharan Africa and to a less extent in South America, reports form
other regions should be supported.
In the conclusion, authors stated that TDF has a more pronounced effect on renal function during
long-term use than ETV. Given the small difference in found between TDF and ETV in eGRF
decrease (-5.83 vs -4.75 mL/min/1.73m2) I would mitigate the message that requires additional
studies."
Please review this paper.
user
Title: Efficacy and safety of tenofovir disoproxil fumarate versus entecavir in the treatment of
acute-on-chronic liver failure with hepatitis B: a systematic review and meta-analysis
Version: 3 Date: 18 Sep 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: In their present revised version, authors have correctly addressed
comments raised by reviewers. The Discussion is nicely presented, however, authors might
consider the following suggestions to improve their content :
REQUESTED REVISIONS:
Authors ended with only five eligible observational studies all from Asia. Given that HBV is
also highly prevalent in sub-Saharan Africa and to a less extent in South America, reports form
other regions should be supported.
In the conclusion, authors stated that TDF has a more pronounced effect on renal function during
long-term use than ETV. Given the small difference in found between TDF and ETV in eGRF
decrease (-5.83 vs -4.75 mL/min/1.73m2) I would mitigate the message that requires additional
studies."
assistant