Reviewer's report
Title:IkappaBalpha polymorphism at promoter region (rs2233408) influences the
susceptibility of gastric cancer in Chinese
Version: 1Date:13 November 2009
Reviewer: Mauro Magnani
Reviewer's report:
Major Compulsory Revisions
In this study, the athors investigate the association of a genetic variant at
promoter region of IkB -alpha gene and the susceptibility of gastric cancer. In
addition, association with patient outcome was also evaluated.
Since several polymorphisms of NFKBIA gene have been mentioned in the
introduction, the authors should explain more clearly why the rs2233408 variant
in the promoter region has been chosen among the others.
Minor Essential Revisions
The results suggest that heterozygotes and homozygotes for T allele were
associated to reduced gastric cancer risk compared to homozygotes CC, at least
for the intestinal-type. However, given the very small number of cases that were
taken into consideration for both the diffuse and the mix gastric cancer types, the
authors should not exclude the same association. In my opinion the authors
should include additional cases in this analysis.
Finally, the T heterozygotes were associated to non-cardiac gastric cancer
compared to cardiac gastric cancer. In addition, the authors could not establish
any association between rs2233408 polymorphism and patient outcome.
Discretionary Revisions
On the whole the article is clear and well structured but I suggest a language
revision.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:IkappaBalpha polymorphism at promoter region (rs2233408) influences the
susceptibility of gastric cancer in Chinese
Version: 1Date:13 November 2009
Reviewer: Mauro Magnani
Reviewer's report:
Major Compulsory Revisions
In this study, the athors investigate the association of a genetic variant at
promoter region of IkB -alpha gene and the susceptibility of gastric cancer. In
addition, association with patient outcome was also evaluated.
Since several polymorphisms of NFKBIA gene have been mentioned in the
introduction, the authors should explain more clearly why the rs2233408 variant
in the promoter region has been chosen among the others.
Minor Essential Revisions
The results suggest that heterozygotes and homozygotes for T allele were
associated to reduced gastric cancer risk compared to homozygotes CC, at least
for the intestinal-type. However, given the very small number of cases that were
taken into consideration for both the diffuse and the mix gastric cancer types, the
authors should not exclude the same association. In my opinion the authors
should include additional cases in this analysis.
Finally, the T heterozygotes were associated to non-cardiac gastric cancer
compared to cardiac gastric cancer. In addition, the authors could not establish
any association between rs2233408 polymorphism and patient outcome.
Discretionary Revisions
On the whole the article is clear and well structured but I suggest a language
revision.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:IkappaBalpha polymorphism at promoter region (rs2233408) influences the
susceptibility of gastric cancer in Chinese
Version: 1Date:13 November 2009
Reviewer: Mauro Magnani
Reviewer's report:
Major Compulsory Revisions
In this study, the athors investigate the association of a genetic variant at
promoter region of IkB -alpha gene and the susceptibility of gastric cancer. In
addition, association with patient outcome was also evaluated.
Since several polymorphisms of NFKBIA gene have been mentioned in the
introduction, the authors should explain more clearly why the rs2233408 variant
in the promoter region has been chosen among the others.
Minor Essential Revisions
The results suggest that heterozygotes and homozygotes for T allele were
associated to reduced gastric cancer risk compared to homozygotes CC, at least
for the intestinal-type. However, given the very small number of cases that were
taken into consideration for both the diffuse and the mix gastric cancer types, the
authors should not exclude the same association. In my opinion the authors
should include additional cases in this analysis.
Finally, the T heterozygotes were associated to non-cardiac gastric cancer
compared to cardiac gastric cancer. In addition, the authors could not establish
any association between rs2233408 polymorphism and patient outcome.
Discretionary Revisions
On the whole the article is clear and well structured but I suggest a language
revision.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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