Reviewer's report
Title:Psychological stress induced zinc accumulation and up-regulation of ZIP14
and metallothionein in rat liver
Version: 1Date:27 June 2013
Reviewer: Matthew Cave
Reviewer's report:
Although much is known about zinc dyshomeostasis in medical diseases
(including liver disease), less is known about zinc dyshomesotasis in
psychological stress and the potential role of this liver. This manuscript,
demonstrates hypozincemia following psychological stress in an animal model
due to increased liver uptake related to IL6 induced zip14 expression and cortisol
induced metallothionein expression. The findings appear novel and build on the
author's previous work which is of interest to the field (albeit possibly more
interesting to mental health and zinc researchers moreso than
gastroenterologists). the manuscript is generally well written for English
language, although I do recommend several minor essential revisions.
1);Page 9 - The middle third of the page beginning with "However, body zinc
stores..." and ending with "...in rats treated PS exposure." requires editing for
English language.
2) Page 10 - conclusion requires editing for English language
3) should also indicate in discussion that other modes of action for hypozincemia
including decreased dietary absorption or increased urinary losses are also
possible (and have occured in other zinc deficient states) but were not evaluated
in this study
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Psychological stress induced zinc accumulation and up-regulation of ZIP14
and metallothionein in rat liver
Version: 1Date:27 June 2013
Reviewer: Matthew Cave
Reviewer's report:
Although much is known about zinc dyshomeostasis in medical diseases
(including liver disease), less is known about zinc dyshomesotasis in
psychological stress and the potential role of this liver. This manuscript,
demonstrates hypozincemia following psychological stress in an animal model
due to increased liver uptake related to IL6 induced zip14 expression and cortisol
induced metallothionein expression. The findings appear novel and build on the
author's previous work which is of interest to the field (albeit possibly more
interesting to mental health and zinc researchers moreso than
gastroenterologists). the manuscript is generally well written for English
language, although I do recommend several minor essential revisions.
1);Page 9 - The middle third of the page beginning with "However, body zinc
stores..." and ending with "...in rats treated PS exposure." requires editing for
English language.
2) Page 10 - conclusion requires editing for English language
3) should also indicate in discussion that other modes of action for hypozincemia
including decreased dietary absorption or increased urinary losses are also
possible (and have occured in other zinc deficient states) but were not evaluated
in this study
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Psychological stress induced zinc accumulation and up-regulation of ZIP14
and metallothionein in rat liver
Version: 1Date:27 June 2013
Reviewer: Matthew Cave
Reviewer's report:
Although much is known about zinc dyshomeostasis in medical diseases
(including liver disease), less is known about zinc dyshomesotasis in
psychological stress and the potential role of this liver. This manuscript,
demonstrates hypozincemia following psychological stress in an animal model
due to increased liver uptake related to IL6 induced zip14 expression and cortisol
induced metallothionein expression. The findings appear novel and build on the
author's previous work which is of interest to the field (albeit possibly more
interesting to mental health and zinc researchers moreso than
gastroenterologists). the manuscript is generally well written for English
language, although I do recommend several minor essential revisions.
1);Page 9 - The middle third of the page beginning with "However, body zinc
stores..." and ending with "...in rats treated PS exposure." requires editing for
English language.
2) Page 10 - conclusion requires editing for English language
3) should also indicate in discussion that other modes of action for hypozincemia
including decreased dietary absorption or increased urinary losses are also
possible (and have occured in other zinc deficient states) but were not evaluated
in this study
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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