Title: Impact of Chemotherapy and Radiotherapy on the Survival of Elderly Esophageal Cancer
Patients Undergoing Surgery: A SEER Database Analysis
Version: 10 Date: 06 Oct 2021
Reviewer's report:
The revised paper improved its clarity and quality. Here are two minor comments:
1. In the result session with subtitle of "Analysis in Pre-match Cohort", the following sentences
"... histological grade ("poorly or un-differentiation grade"...) repeated all the hazard ratio listed
in the results table. I'd suggest to remove those repeated result and simplify it as "... poorly or
un-differentiated grade, tumor size #33 mm, T stage >T1, positive lymph nodes, and metastasis
diseases had associated with increased risk of death.".
2. In the 3rd paragraph of the discussion session, I'd suggest to delete the following sentence
since these are results. The discussion should focus on why CRT treatment in low-risk patients.
Here are the sentences that can be removed "Using the variables mentioned above, a nomogram
was established to estimate the risk score for every patient, and the high- and low-risk groups
were derived from the whole-population cohort. With a series of analyses, CRT was shown to
decrease the probability of CSD and to improve the survival in the high-risk group, indicating
that elderly patients with EC characterized as middle- and upper-third of tumor location, poorly-
and undifferentiated of histological grade, # 33 mm of tumor size, advanced T stage, positive
lymph node, and/or metastasis tend to benefit from the relatively aggressive treatment. ".
Title: Impact of Chemotherapy and Radiotherapy on the Survival of Elderly Esophageal Cancer
Patients Undergoing Surgery: A SEER Database Analysis
Version: 10 Date: 06 Oct 2021
Reviewer's report:
The revised paper improved its clarity and quality. Here are two minor comments:
1. In the result session with subtitle of "Analysis in Pre-match Cohort", the following sentences
"... histological grade ("poorly or un-differentiation grade"...) repeated all the hazard ratio listed
in the results table. I'd suggest to remove those repeated result and simplify it as "... poorly or
un-differentiated grade, tumor size #33 mm, T stage >T1, positive lymph nodes, and metastasis
diseases had associated with increased risk of death.".
2. In the 3rd paragraph of the discussion session, I'd suggest to delete the following sentence
since these are results. The discussion should focus on why CRT treatment in low-risk patients.
Here are the sentences that can be removed "Using the variables mentioned above, a nomogram
was established to estimate the risk score for every patient, and the high- and low-risk groups
were derived from the whole-population cohort. With a series of analyses, CRT was shown to
decrease the probability of CSD and to improve the survival in the high-risk group, indicating
that elderly patients with EC characterized as middle- and upper-third of tumor location, poorly-
and undifferentiated of histological grade, # 33 mm of tumor size, advanced T stage, positive
lymph node, and/or metastasis tend to benefit from the relatively aggressive treatment. ".
Please review this paper.
user
Title: Impact of Chemotherapy and Radiotherapy on the Survival of Elderly Esophageal Cancer
Patients Undergoing Surgery: A SEER Database Analysis
Version: 10 Date: 06 Oct 2021
Reviewer's report:
The revised paper improved its clarity and quality. Here are two minor comments:
1. In the result session with subtitle of "Analysis in Pre-match Cohort", the following sentences
"... histological grade ("poorly or un-differentiation grade"...) repeated all the hazard ratio listed
in the results table. I'd suggest to remove those repeated result and simplify it as "... poorly or
un-differentiated grade, tumor size #33 mm, T stage >T1, positive lymph nodes, and metastasis
diseases had associated with increased risk of death.".
2. In the 3rd paragraph of the discussion session, I'd suggest to delete the following sentence
since these are results. The discussion should focus on why CRT treatment in low-risk patients.
Here are the sentences that can be removed "Using the variables mentioned above, a nomogram
was established to estimate the risk score for every patient, and the high- and low-risk groups
were derived from the whole-population cohort. With a series of analyses, CRT was shown to
decrease the probability of CSD and to improve the survival in the high-risk group, indicating
that elderly patients with EC characterized as middle- and upper-third of tumor location, poorly-
and undifferentiated of histological grade, # 33 mm of tumor size, advanced T stage, positive
lymph node, and/or metastasis tend to benefit from the relatively aggressive treatment. ".
assistant