Title: Network meta-analysis of adjuvant treatments for patients with hepatocellular carcinoma
after curative resection
Version: 1 Date: 20 Jun 2023
Reviewer:  Ken Shirabe
Reviewer's report:
Comments:
It is an interesting and this paper is well structured and will give useful information to
the readers .However, it requires a modification in the following points
Major comments
1. Some trials in this study, include HCC patients with vascular invasion, Surgical margins
are diverse for different trails. Especially, vascular invasion is a strong factor that affects HCC
recurrence and survival. The authors should discuss the effects and bias, affecting the results by
the background difference.
2. The primary outcome was the prevention of recurrence between different procedures. The
second outcomes were one-year survival, three-year survival and five-year survival. By timing
of outcome, the results are different. The authors should discuss about the reason in differences
in the impact of procedures on survival and recurrence.
Minor comment
1. You should correct one-year survival to three-year survival, on page 5 line 206.
Title: Network meta-analysis of adjuvant treatments for patients with hepatocellular carcinoma
after curative resection
Version: 1 Date: 20 Jun 2023
Reviewer:  Ken Shirabe
Reviewer's report:
Comments:
It is an interesting and this paper is well structured and will give useful information to
the readers .However, it requires a modification in the following points
Major comments
1. Some trials in this study, include HCC patients with vascular invasion, Surgical margins
are diverse for different trails. Especially, vascular invasion is a strong factor that affects HCC
recurrence and survival. The authors should discuss the effects and bias, affecting the results by
the background difference.
2. The primary outcome was the prevention of recurrence between different procedures. The
second outcomes were one-year survival, three-year survival and five-year survival. By timing
of outcome, the results are different. The authors should discuss about the reason in differences
in the impact of procedures on survival and recurrence.
Minor comment
1. You should correct one-year survival to three-year survival, on page 5 line 206.
Please review this paper.
user
Title: Network meta-analysis of adjuvant treatments for patients with hepatocellular carcinoma
after curative resection
Version: 1 Date: 20 Jun 2023
Reviewer:  Ken Shirabe
Reviewer's report:
Comments:
It is an interesting and this paper is well structured and will give useful information to
the readers .However, it requires a modification in the following points
Major comments
1. Some trials in this study, include HCC patients with vascular invasion, Surgical margins
are diverse for different trails. Especially, vascular invasion is a strong factor that affects HCC
recurrence and survival. The authors should discuss the effects and bias, affecting the results by
the background difference.
2. The primary outcome was the prevention of recurrence between different procedures. The
second outcomes were one-year survival, three-year survival and five-year survival. By timing
of outcome, the results are different. The authors should discuss about the reason in differences
in the impact of procedures on survival and recurrence.
Minor comment
1. You should correct one-year survival to three-year survival, on page 5 line 206.
assistant