Reviewer ’s report  
 
Title: Preliminary analysis of Single Nucleotide Polymorph isms in IL -10, IL -4 and IL -4Rα 
genes and profile of circulating cytokines in patients with Gastric Cancer  
 
Version: 1 Date: 20 Nov 2018  
 
Reviewer: Reviewer 2  
 
Reviewer's report:  
 
REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER:  
 
Has the author addressed your concerns sufficiently for you to now recommend the work as a 
technically sound contribution? Yes  
 
Reviewer comments: Summa ry 
The authors have addressed all the suggestions in the peer review.  
 
Methods  
The authors have included the requested patient information (age, sex and other data) in the 
Table II.  
Tables  
The tables were enclosed separately.  
 
Figures  
The figure number has been corrected.  
 
References  
The authors have added new references, as it has been suggested in the peer review, including 
the references on interleukin gene polymorphisms and the risk of gastric cancer.  
 
Editorial corrections  
The auth ors have made the corrections mentioned in the peer review.  
 
Conclusion  
The authors of the study have responded to all the comments included in the peer review. Thus, 
this paper may be considered as a technically sound contribution. The results will be int eresting 
for both oncologists and gastroenterologists.  
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written En glish  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares  in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you recei ved reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organization, Research Square. Reviewers with 
declared or apparent competing interests are not utilized for these reviews. Th is reviewer has 
agreed to publication of their comments online under a Creative Commons Attribution License 
attributed to Research Square and was paid a small honorarium for completing the review within 
a specified timeframe. Honoraria for reviews such as this are paid regardless of the reviewer 
recommendation.  
 
I agree to the open peer r eview policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included a s confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Preliminary analysis of Single Nucleotide Polymorph isms in IL -10, IL -4 and IL -4Rα 
genes and profile of circulating cytokines in patients with Gastric Cancer  
 
Version: 1 Date: 20 Nov 2018  
 
Reviewer: Reviewer 2  
 
Reviewer's report:  
 
REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER:  
 
Has the author addressed your concerns sufficiently for you to now recommend the work as a 
technically sound contribution? Yes  
 
Reviewer comments: Summa ry 
The authors have addressed all the suggestions in the peer review.  
 
Methods  
The authors have included the requested patient information (age, sex and other data) in the 
Table II.  
Tables  
The tables were enclosed separately.  
 
Figures  
The figure number has been corrected.  
 
References  
The authors have added new references, as it has been suggested in the peer review, including 
the references on interleukin gene polymorphisms and the risk of gastric cancer.  
 
Editorial corrections  
The auth ors have made the corrections mentioned in the peer review.  
 
Conclusion  
The authors of the study have responded to all the comments included in the peer review. Thus, 
this paper may be considered as a technically sound contribution. The results will be int eresting 
for both oncologists and gastroenterologists.  
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written En glish  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares  in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you recei ved reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organization, Research Square. Reviewers with 
declared or apparent competing interests are not utilized for these reviews. Th is reviewer has 
agreed to publication of their comments online under a Creative Commons Attribution License 
attributed to Research Square and was paid a small honorarium for completing the review within 
a specified timeframe. Honoraria for reviews such as this are paid regardless of the reviewer 
recommendation.  
 
I agree to the open peer r eview policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included a s confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Preliminary analysis of Single Nucleotide Polymorph isms in IL -10, IL -4 and IL -4Rα 
genes and profile of circulating cytokines in patients with Gastric Cancer  
 
Version: 1 Date: 20 Nov 2018  
 
Reviewer: Reviewer 2  
 
Reviewer's report:  
 
REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER:  
 
Has the author addressed your concerns sufficiently for you to now recommend the work as a 
technically sound contribution? Yes  
 
Reviewer comments: Summa ry 
The authors have addressed all the suggestions in the peer review.  
 
Methods  
The authors have included the requested patient information (age, sex and other data) in the 
Table II.  
Tables  
The tables were enclosed separately.  
 
Figures  
The figure number has been corrected.  
 
References  
The authors have added new references, as it has been suggested in the peer review, including 
the references on interleukin gene polymorphisms and the risk of gastric cancer.  
 
Editorial corrections  
The auth ors have made the corrections mentioned in the peer review.  
 
Conclusion  
The authors of the study have responded to all the comments included in the peer review. Thus, 
this paper may be considered as a technically sound contribution. The results will be int eresting 
for both oncologists and gastroenterologists.  
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written En glish  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares  in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you recei ved reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organization, Research Square. Reviewers with 
declared or apparent competing interests are not utilized for these reviews. Th is reviewer has 
agreed to publication of their comments online under a Creative Commons Attribution License 
attributed to Research Square and was paid a small honorarium for completing the review within 
a specified timeframe. Honoraria for reviews such as this are paid regardless of the reviewer 
recommendation.  
 
I agree to the open peer r eview policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included a s confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant