Title: Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant
chemoradiotherapy for locally advanced rectal cancer: An updated meta-analysis
Version: 1 Date: 18 Nov 2024
Reviewer's report:
1) The new-castle Ottawa scale is used for observational studies. Please use another tool for
assessing risk of bias in RCTs
2) Risk of bias assessment is done for individual outcomes and cannot be generalized to every
outcome. Either define the main outcome measure and assess risk of bias for that and report that
particular only, or perform risk of bias assessment for every outcome.
3) Local recurrence and distant metastasis are time dependenet variables, using Odds ratio as
the outcomes cannot be justified. Please use meta-analysis with Hazard ratio as the outcome
measure.
4) Quality of strength of evidence should be reported
5) Sensitivity analysis should be reported with only prospective studies
Title: Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant
chemoradiotherapy for locally advanced rectal cancer: An updated meta-analysis
Version: 1 Date: 18 Nov 2024
Reviewer's report:
1) The new-castle Ottawa scale is used for observational studies. Please use another tool for
assessing risk of bias in RCTs
2) Risk of bias assessment is done for individual outcomes and cannot be generalized to every
outcome. Either define the main outcome measure and assess risk of bias for that and report that
particular only, or perform risk of bias assessment for every outcome.
3) Local recurrence and distant metastasis are time dependenet variables, using Odds ratio as
the outcomes cannot be justified. Please use meta-analysis with Hazard ratio as the outcome
measure.
4) Quality of strength of evidence should be reported
5) Sensitivity analysis should be reported with only prospective studies
Please review this paper.
user
Title: Short- and long-term outcomes of neoadjuvant chemotherapy compared with neoadjuvant
chemoradiotherapy for locally advanced rectal cancer: An updated meta-analysis
Version: 1 Date: 18 Nov 2024
Reviewer's report:
1) The new-castle Ottawa scale is used for observational studies. Please use another tool for
assessing risk of bias in RCTs
2) Risk of bias assessment is done for individual outcomes and cannot be generalized to every
outcome. Either define the main outcome measure and assess risk of bias for that and report that
particular only, or perform risk of bias assessment for every outcome.
3) Local recurrence and distant metastasis are time dependenet variables, using Odds ratio as
the outcomes cannot be justified. Please use meta-analysis with Hazard ratio as the outcome
measure.
4) Quality of strength of evidence should be reported
5) Sensitivity analysis should be reported with only prospective studies
assistant