Title: Efficacy and safety of tenofovir disoproxil fumarate versus entecavir in the treatment of
acute-on-chronic liver failure with hepatitis B: a systematic review and meta-analysis
Version: 1 Date: 17 Jun 2023
Reviewer's report:
Thank you for the opportunity to review your manuscript "Efficacy and safety of tenofovir
disoproxil fumarate versus entecavir in the treatment of acute-on-chronic liver failure with
hepatitis B: a systematic review and meta-analysis" where you examined whether there was a
difference between the use of entecavir and tenofovir disoproxil fumarate in HBV related acute/
chronic liver failure. You found no difference with regards to survival (either short term or long
term) between the two agent with the major difference being the agents being renal function
with tenofovir having worse outcomes.
Comments on the manuscript are as follows:
1. Could you please include the search strategy used for this analysis (i.e. exact strings searched).
2. It is unclear which arm is which on the figures; please label them.
3. How was data extracted from the graphs? Was this done by hand or what technique was used?
Title: Efficacy and safety of tenofovir disoproxil fumarate versus entecavir in the treatment of
acute-on-chronic liver failure with hepatitis B: a systematic review and meta-analysis
Version: 1 Date: 17 Jun 2023
Reviewer's report:
Thank you for the opportunity to review your manuscript "Efficacy and safety of tenofovir
disoproxil fumarate versus entecavir in the treatment of acute-on-chronic liver failure with
hepatitis B: a systematic review and meta-analysis" where you examined whether there was a
difference between the use of entecavir and tenofovir disoproxil fumarate in HBV related acute/
chronic liver failure. You found no difference with regards to survival (either short term or long
term) between the two agent with the major difference being the agents being renal function
with tenofovir having worse outcomes.
Comments on the manuscript are as follows:
1. Could you please include the search strategy used for this analysis (i.e. exact strings searched).
2. It is unclear which arm is which on the figures; please label them.
3. How was data extracted from the graphs? Was this done by hand or what technique was used?
Please review this paper.
user
Title: Efficacy and safety of tenofovir disoproxil fumarate versus entecavir in the treatment of
acute-on-chronic liver failure with hepatitis B: a systematic review and meta-analysis
Version: 1 Date: 17 Jun 2023
Reviewer's report:
Thank you for the opportunity to review your manuscript "Efficacy and safety of tenofovir
disoproxil fumarate versus entecavir in the treatment of acute-on-chronic liver failure with
hepatitis B: a systematic review and meta-analysis" where you examined whether there was a
difference between the use of entecavir and tenofovir disoproxil fumarate in HBV related acute/
chronic liver failure. You found no difference with regards to survival (either short term or long
term) between the two agent with the major difference being the agents being renal function
with tenofovir having worse outcomes.
Comments on the manuscript are as follows:
1. Could you please include the search strategy used for this analysis (i.e. exact strings searched).
2. It is unclear which arm is which on the figures; please label them.
3. How was data extracted from the graphs? Was this done by hand or what technique was used?
assistant