Title: Influencing factors and predictive model of postoperative infection in patients with
primary hepatic carcinoma
Version: 3 Date: 15 Feb 2023
Reviewer:  Takayuki Shimizu
Reviewer's report:
The authors has made the better predictive nomogram model for postoperative infection in
patients with HCC. This predictive model is acceptable and practical because BMI, AFP, total
bilirubin, blood loss and bile leakage had reported as predictors for infection.
I ask some questions to the authors.
Q1; What about an antibiotics intraoperatively? In method, there is no explanation about
intraoperative antibiotics. Do you use an antibiotics intraoperatively to prevent postoperative
infection? If you use an antibiotics intraoperatively, could you mention intraoperative antibiotics
in the method section?
Q2; Do you think how does intraoperative broad spectrum antibiotics or antibiotics-coated
sutures influence postoperative infection?
Q3; As you know, bile leakage is majorly associated with infection. How do we do intraoperative
or postoperative interventions to avoid or improve bile leakage? Does early intervention for
bile leakage such as endoscopic bile drainage or percutaneous drainage  improve  postoperative
infection?
Title: Influencing factors and predictive model of postoperative infection in patients with
primary hepatic carcinoma
Version: 3 Date: 15 Feb 2023
Reviewer:  Takayuki Shimizu
Reviewer's report:
The authors has made the better predictive nomogram model for postoperative infection in
patients with HCC. This predictive model is acceptable and practical because BMI, AFP, total
bilirubin, blood loss and bile leakage had reported as predictors for infection.
I ask some questions to the authors.
Q1; What about an antibiotics intraoperatively? In method, there is no explanation about
intraoperative antibiotics. Do you use an antibiotics intraoperatively to prevent postoperative
infection? If you use an antibiotics intraoperatively, could you mention intraoperative antibiotics
in the method section?
Q2; Do you think how does intraoperative broad spectrum antibiotics or antibiotics-coated
sutures influence postoperative infection?
Q3; As you know, bile leakage is majorly associated with infection. How do we do intraoperative
or postoperative interventions to avoid or improve bile leakage? Does early intervention for
bile leakage such as endoscopic bile drainage or percutaneous drainage  improve  postoperative
infection?
Please review this paper.
user
Title: Influencing factors and predictive model of postoperative infection in patients with
primary hepatic carcinoma
Version: 3 Date: 15 Feb 2023
Reviewer:  Takayuki Shimizu
Reviewer's report:
The authors has made the better predictive nomogram model for postoperative infection in
patients with HCC. This predictive model is acceptable and practical because BMI, AFP, total
bilirubin, blood loss and bile leakage had reported as predictors for infection.
I ask some questions to the authors.
Q1; What about an antibiotics intraoperatively? In method, there is no explanation about
intraoperative antibiotics. Do you use an antibiotics intraoperatively to prevent postoperative
infection? If you use an antibiotics intraoperatively, could you mention intraoperative antibiotics
in the method section?
Q2; Do you think how does intraoperative broad spectrum antibiotics or antibiotics-coated
sutures influence postoperative infection?
Q3; As you know, bile leakage is majorly associated with infection. How do we do intraoperative
or postoperative interventions to avoid or improve bile leakage? Does early intervention for
bile leakage such as endoscopic bile drainage or percutaneous drainage  improve  postoperative
infection?
assistant