Title: Impact of donor age on liver transplant outcomes in patients with hepatocellular
carcinoma: analysis of the SRTR database
Version: 4 Date: 13 Feb 2021
Reviewer's report:
The authors provide in their revised version the cause of death. However, in my previous review,
I asked for liver-related mortality. Maybe that was a misunderstanding. What I meant was the
liver-specific survival? Can the authors provide that.
I also asked to shorten the discussion. It is still very long (4.5 pages) and somehow hard to read.
Please streamline it. Only discuss what is truly relevant.
The survival differences of the four groups are minimal and only significant because of the
large sample size included. Statistical significance does not mean clinical relevance. Instead of
elaborating on these small differences between the groups in the discussion, you should just state
that differences were small. This is actually good, as it suggests that older donor age may not
implicate long-term outcome in a clinically relevant way.
Title: Impact of donor age on liver transplant outcomes in patients with hepatocellular
carcinoma: analysis of the SRTR database
Version: 4 Date: 13 Feb 2021
Reviewer's report:
The authors provide in their revised version the cause of death. However, in my previous review,
I asked for liver-related mortality. Maybe that was a misunderstanding. What I meant was the
liver-specific survival? Can the authors provide that.
I also asked to shorten the discussion. It is still very long (4.5 pages) and somehow hard to read.
Please streamline it. Only discuss what is truly relevant.
The survival differences of the four groups are minimal and only significant because of the
large sample size included. Statistical significance does not mean clinical relevance. Instead of
elaborating on these small differences between the groups in the discussion, you should just state
that differences were small. This is actually good, as it suggests that older donor age may not
implicate long-term outcome in a clinically relevant way.
Please review this paper.
user
Title: Impact of donor age on liver transplant outcomes in patients with hepatocellular
carcinoma: analysis of the SRTR database
Version: 4 Date: 13 Feb 2021
Reviewer's report:
The authors provide in their revised version the cause of death. However, in my previous review,
I asked for liver-related mortality. Maybe that was a misunderstanding. What I meant was the
liver-specific survival? Can the authors provide that.
I also asked to shorten the discussion. It is still very long (4.5 pages) and somehow hard to read.
Please streamline it. Only discuss what is truly relevant.
The survival differences of the four groups are minimal and only significant because of the
large sample size included. Statistical significance does not mean clinical relevance. Instead of
elaborating on these small differences between the groups in the discussion, you should just state
that differences were small. This is actually good, as it suggests that older donor age may not
implicate long-term outcome in a clinically relevant way.
assistant