Title: The effect of cardiovascular disease on the perioperative period of radical surgery in
elderly rectal cancer
Version: 1 Date: 20 Feb 2024
Reviewer's report:
The authors report a retrospective study about the impact of cardiovascular comorbidities in
elderly (>75 years) on postoperative outcomes of radical surgeery for rectal cancer, using
a propensity score. Patients with cardiovascular comorbidities were sgnificantly associated
with severe complications, especially anastomotic leakage and cardiac disorders, in spite of
postoperative ICU admission.
Major comments:
- Why elderly was considered after 75 years?
- It would be interesting to know the proportion of excluded patients, particularly distant
metastasis, palliative surgery and emergency surgery due to intestinal obstruction and intestinal
perforation , which are usually the more important prooportion of elderly patients wiith
colorectal cancer
- The definition of cardiovascular comorbidities does not include vascular diseases such as aortic
aneurism, peripheral arteriopathy, cerebral attack etc..
- neoadjuvant chemoradiotherapy was not indicated for T3 stage, it’s not usual. Please justify.
- Why patients over 80 years of age were not treated with nCRT?
- It’s surprising that ASA score was not significantly different betweeen patients with
cardiovascular disease and those without. Do you have any explanation?
- In table 1: Does Low anterior resection mean with anastomosis?
Is there patients with anastomosis and temporary diverting stoma
- Patients who went to ICU: is it scheduled ou not because intraoperative complication?
Minor comments:
- pathological instead of pathologic
- it’s difficult to obtain written informed consent in a retrospective study starting in 2011. Did
you loss somee patients? If yes, and probably, it would be intresting to know this proportion too.
- outcomes instead of diseases for the definition of postoperative complication
- Tables: from instead of in, in the title
- Tables: significant p value could be in bold
Title: The effect of cardiovascular disease on the perioperative period of radical surgery in
elderly rectal cancer
Version: 1 Date: 20 Feb 2024
Reviewer's report:
The authors report a retrospective study about the impact of cardiovascular comorbidities in
elderly (>75 years) on postoperative outcomes of radical surgeery for rectal cancer, using
a propensity score. Patients with cardiovascular comorbidities were sgnificantly associated
with severe complications, especially anastomotic leakage and cardiac disorders, in spite of
postoperative ICU admission.
Major comments:
- Why elderly was considered after 75 years?
- It would be interesting to know the proportion of excluded patients, particularly distant
metastasis, palliative surgery and emergency surgery due to intestinal obstruction and intestinal
perforation , which are usually the more important prooportion of elderly patients wiith
colorectal cancer
- The definition of cardiovascular comorbidities does not include vascular diseases such as aortic
aneurism, peripheral arteriopathy, cerebral attack etc..
- neoadjuvant chemoradiotherapy was not indicated for T3 stage, it’s not usual. Please justify.
- Why patients over 80 years of age were not treated with nCRT?
- It’s surprising that ASA score was not significantly different betweeen patients with
cardiovascular disease and those without. Do you have any explanation?
- In table 1: Does Low anterior resection mean with anastomosis?
Is there patients with anastomosis and temporary diverting stoma
- Patients who went to ICU: is it scheduled ou not because intraoperative complication?
Minor comments:
- pathological instead of pathologic
- it’s difficult to obtain written informed consent in a retrospective study starting in 2011. Did
you loss somee patients? If yes, and probably, it would be intresting to know this proportion too.
- outcomes instead of diseases for the definition of postoperative complication
- Tables: from instead of in, in the title
- Tables: significant p value could be in bold
Please review this paper.
user
Title: The effect of cardiovascular disease on the perioperative period of radical surgery in
elderly rectal cancer
Version: 1 Date: 20 Feb 2024
Reviewer's report:
The authors report a retrospective study about the impact of cardiovascular comorbidities in
elderly (>75 years) on postoperative outcomes of radical surgeery for rectal cancer, using
a propensity score. Patients with cardiovascular comorbidities were sgnificantly associated
with severe complications, especially anastomotic leakage and cardiac disorders, in spite of
postoperative ICU admission.
Major comments:
- Why elderly was considered after 75 years?
- It would be interesting to know the proportion of excluded patients, particularly distant
metastasis, palliative surgery and emergency surgery due to intestinal obstruction and intestinal
perforation , which are usually the more important prooportion of elderly patients wiith
colorectal cancer
- The definition of cardiovascular comorbidities does not include vascular diseases such as aortic
aneurism, peripheral arteriopathy, cerebral attack etc..
- neoadjuvant chemoradiotherapy was not indicated for T3 stage, it’s not usual. Please justify.
- Why patients over 80 years of age were not treated with nCRT?
- It’s surprising that ASA score was not significantly different betweeen patients with
cardiovascular disease and those without. Do you have any explanation?
- In table 1: Does Low anterior resection mean with anastomosis?
Is there patients with anastomosis and temporary diverting stoma
- Patients who went to ICU: is it scheduled ou not because intraoperative complication?
Minor comments:
- pathological instead of pathologic
- it’s difficult to obtain written informed consent in a retrospective study starting in 2011. Did
you loss somee patients? If yes, and probably, it would be intresting to know this proportion too.
- outcomes instead of diseases for the definition of postoperative complication
- Tables: from instead of in, in the title
- Tables: significant p value could be in bold
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