Title: Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease
(ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-
G including 15 cases followed more than 5 years.
Version: 1 Date: 06 Jun 2021
Reviewer's report:
The inclusion criteria of ESD-G are not clear. The PPI refractory GERD might include
Functional heartburn (FH) and Reflux hypersensitivity (RH). Both the 24 hour-pH and
impedance monitoring are necessary for the exclusion of these diseases. Furthermore, 24 hour-
pH monitoring is also required for checking the insufficient effect of PPI. Therefore, the PPI
refractory GERD in this study might include several functional esophageal disorders, and I
concern about that the patients with FH and RH might be performed ESD-G in this study.
The way of evaluation is not unified. Despite containing many patients with NERD, it is strange
to evaluate the effect of ESD-G by endoscopy. FSSG is also not effective for the evaluation of
FH and RH. The evaluation of gastric acid secretion suppressants is not sufficient in the cases
without 24 hour-pH monitoring.
Title: Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease
(ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-
G including 15 cases followed more than 5 years.
Version: 1 Date: 06 Jun 2021
Reviewer's report:
The inclusion criteria of ESD-G are not clear. The PPI refractory GERD might include
Functional heartburn (FH) and Reflux hypersensitivity (RH). Both the 24 hour-pH and
impedance monitoring are necessary for the exclusion of these diseases. Furthermore, 24 hour-
pH monitoring is also required for checking the insufficient effect of PPI. Therefore, the PPI
refractory GERD in this study might include several functional esophageal disorders, and I
concern about that the patients with FH and RH might be performed ESD-G in this study.
The way of evaluation is not unified. Despite containing many patients with NERD, it is strange
to evaluate the effect of ESD-G by endoscopy. FSSG is also not effective for the evaluation of
FH and RH. The evaluation of gastric acid secretion suppressants is not sufficient in the cases
without 24 hour-pH monitoring.
Please review this paper.
user
Title: Outcomes of endoscopic submucosal dissection for gastroesophageal reflux disease
(ESD-G) for medication-refractory gastroesophageal reflux disease: 35 cases underwent ESD-
G including 15 cases followed more than 5 years.
Version: 1 Date: 06 Jun 2021
Reviewer's report:
The inclusion criteria of ESD-G are not clear. The PPI refractory GERD might include
Functional heartburn (FH) and Reflux hypersensitivity (RH). Both the 24 hour-pH and
impedance monitoring are necessary for the exclusion of these diseases. Furthermore, 24 hour-
pH monitoring is also required for checking the insufficient effect of PPI. Therefore, the PPI
refractory GERD in this study might include several functional esophageal disorders, and I
concern about that the patients with FH and RH might be performed ESD-G in this study.
The way of evaluation is not unified. Despite containing many patients with NERD, it is strange
to evaluate the effect of ESD-G by endoscopy. FSSG is also not effective for the evaluation of
FH and RH. The evaluation of gastric acid secretion suppressants is not sufficient in the cases
without 24 hour-pH monitoring.
assistant