Title: Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis
Version: 2 Date: 26 Jan 2021
Reviewer's report:
The present study was performed to evaluate the mucosal IL-12/23 expression and its
relationship with endoscopic severity, histological activity, and UC relapse.
The manuscript proposes points of novelty about a critical role of IL-12 in UC pathogenesis and
the molecular mechanism of UC relapse. The statistical methods are adequate.
I have a couple of request:
1) Do the authors have evidence about the serum levels of IL-12 and IL-23?
2) It could be of interest to evaluate the expression of tight junctions (claudin-2 occludin and
zonulin-1) and their correlation with IL-12 expression
Title: Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis
Version: 2 Date: 26 Jan 2021
Reviewer's report:
The present study was performed to evaluate the mucosal IL-12/23 expression and its
relationship with endoscopic severity, histological activity, and UC relapse.
The manuscript proposes points of novelty about a critical role of IL-12 in UC pathogenesis and
the molecular mechanism of UC relapse. The statistical methods are adequate.
I have a couple of request:
1) Do the authors have evidence about the serum levels of IL-12 and IL-23?
2) It could be of interest to evaluate the expression of tight junctions (claudin-2 occludin and
zonulin-1) and their correlation with IL-12 expression
Please review this paper.
user
Title: Increased mucosal IL-12 expression is associated with relapse of ulcerative colitis
Version: 2 Date: 26 Jan 2021
Reviewer's report:
The present study was performed to evaluate the mucosal IL-12/23 expression and its
relationship with endoscopic severity, histological activity, and UC relapse.
The manuscript proposes points of novelty about a critical role of IL-12 in UC pathogenesis and
the molecular mechanism of UC relapse. The statistical methods are adequate.
I have a couple of request:
1) Do the authors have evidence about the serum levels of IL-12 and IL-23?
2) It could be of interest to evaluate the expression of tight junctions (claudin-2 occludin and
zonulin-1) and their correlation with IL-12 expression
assistant