Reviewer's report
Title:Differences in the mutations of K-ras and mitochondrial DNA and in
microsatellite instability between Vietnamese and Japanese colorectal cancers
Version:4Date:5 October 2014
Reviewer: Barbara Pardini
Reviewer's report:
Major Compulsory Revisions
The authors reply in a sufficient manner to the points raised by the Reviewer.
However, there are still 2 main points to be clarified:
1) Figure 1 is really terrible. I understand that the assay could be tricky and to
obtain a good image may be hard, but as it is (and now it seems that Authors
magnified it making it even worst) the image is really not telling much.
2) I still believe that there was not a proof reading by an English -Native speaker,
since in the text that ere are many repetitions and not clear sentences..The
modified title, for example is not so clear and correct: I would suggest
"Differences in K-ras mutations, mitochondrial DNA, and microsatellite instability
between Vietnamese and Japanese colorectal cancers patients"
For the rest I am satisfied with the replies given by the Authors.
Discretionary Revisions
In the future, I would suggest the Authors to improve the number of samples and
to be more careful in the comparison of different populations trying to avoid
possible bias.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Differences in the mutations of K-ras and mitochondrial DNA and in
microsatellite instability between Vietnamese and Japanese colorectal cancers
Version:4Date:5 October 2014
Reviewer: Barbara Pardini
Reviewer's report:
Major Compulsory Revisions
The authors reply in a sufficient manner to the points raised by the Reviewer.
However, there are still 2 main points to be clarified:
1) Figure 1 is really terrible. I understand that the assay could be tricky and to
obtain a good image may be hard, but as it is (and now it seems that Authors
magnified it making it even worst) the image is really not telling much.
2) I still believe that there was not a proof reading by an English -Native speaker,
since in the text that ere are many repetitions and not clear sentences..The
modified title, for example is not so clear and correct: I would suggest
"Differences in K-ras mutations, mitochondrial DNA, and microsatellite instability
between Vietnamese and Japanese colorectal cancers patients"
For the rest I am satisfied with the replies given by the Authors.
Discretionary Revisions
In the future, I would suggest the Authors to improve the number of samples and
to be more careful in the comparison of different populations trying to avoid
possible bias.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Differences in the mutations of K-ras and mitochondrial DNA and in
microsatellite instability between Vietnamese and Japanese colorectal cancers
Version:4Date:5 October 2014
Reviewer: Barbara Pardini
Reviewer's report:
Major Compulsory Revisions
The authors reply in a sufficient manner to the points raised by the Reviewer.
However, there are still 2 main points to be clarified:
1) Figure 1 is really terrible. I understand that the assay could be tricky and to
obtain a good image may be hard, but as it is (and now it seems that Authors
magnified it making it even worst) the image is really not telling much.
2) I still believe that there was not a proof reading by an English -Native speaker,
since in the text that ere are many repetitions and not clear sentences..The
modified title, for example is not so clear and correct: I would suggest
"Differences in K-ras mutations, mitochondrial DNA, and microsatellite instability
between Vietnamese and Japanese colorectal cancers patients"
For the rest I am satisfied with the replies given by the Authors.
Discretionary Revisions
In the future, I would suggest the Authors to improve the number of samples and
to be more careful in the comparison of different populations trying to avoid
possible bias.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant