Title: The intestinal flora and nutritional status and immune function characteristics of obese
colon cancer patients
Version: 3 Date: 03 Jun 2024
Reviewer's report:
The manuscript improved significantly.
A few minor issues still remained:
1. A  thorough read to correct a few grammar / wording issues is needed.
2. The used survival analysis method (repeated chi-squared test) still raises some questions,
as no standard method had been used. Indeed, the logrank method is based on the same chi-
aquared testing basis, however, in Authors'  method no p-value corrections were mentioned. It
is suggested, that Authors should also include some additional testing methods. E.g., perform
pairwise logrank-test for  every possible combinations (A-B , A-C and B-C) followed by a Holm
pvalue correction. Or the same, just with Cox regression method. These test can provide more
information about the survival curves, compared to the current chi-square-based methodology.
Title: The intestinal flora and nutritional status and immune function characteristics of obese
colon cancer patients
Version: 3 Date: 03 Jun 2024
Reviewer's report:
The manuscript improved significantly.
A few minor issues still remained:
1. A  thorough read to correct a few grammar / wording issues is needed.
2. The used survival analysis method (repeated chi-squared test) still raises some questions,
as no standard method had been used. Indeed, the logrank method is based on the same chi-
aquared testing basis, however, in Authors'  method no p-value corrections were mentioned. It
is suggested, that Authors should also include some additional testing methods. E.g., perform
pairwise logrank-test for  every possible combinations (A-B , A-C and B-C) followed by a Holm
pvalue correction. Or the same, just with Cox regression method. These test can provide more
information about the survival curves, compared to the current chi-square-based methodology.
Please review this paper.
user
Title: The intestinal flora and nutritional status and immune function characteristics of obese
colon cancer patients
Version: 3 Date: 03 Jun 2024
Reviewer's report:
The manuscript improved significantly.
A few minor issues still remained:
1. A  thorough read to correct a few grammar / wording issues is needed.
2. The used survival analysis method (repeated chi-squared test) still raises some questions,
as no standard method had been used. Indeed, the logrank method is based on the same chi-
aquared testing basis, however, in Authors'  method no p-value corrections were mentioned. It
is suggested, that Authors should also include some additional testing methods. E.g., perform
pairwise logrank-test for  every possible combinations (A-B , A-C and B-C) followed by a Holm
pvalue correction. Or the same, just with Cox regression method. These test can provide more
information about the survival curves, compared to the current chi-square-based methodology.
assistant