Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 2 Date: 28 Aug 2022
Reviewer's report:
Gastric cancer is caused by the interaction of genes and environmental factors. The purpose of
this study is of great significance to analyze the risk of GC by combining gene polymorphism and
dietary factors. But there are a few questions I want answered. First, whether the significantly
lower GC risk in those who were overweight and obese people shown in the second part of
the results is consistent with other published studies. Second, when analyzing the association
between MAP3K1 gene polymorphism and the risk of GC in the third part, whether to consider
the relationship between the number of bad alleles and the risk of GC? Finally, in the discussion
section, you listed the advantages and limitations of this study. I noticed that the sample
representativeness was not good (lines 290-292). This is a serious problem in my opinion,
which may affect the reliability and persuasiveness of the whole study and greatly reduce the
significance of the study.
Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 2 Date: 28 Aug 2022
Reviewer's report:
Gastric cancer is caused by the interaction of genes and environmental factors. The purpose of
this study is of great significance to analyze the risk of GC by combining gene polymorphism and
dietary factors. But there are a few questions I want answered. First, whether the significantly
lower GC risk in those who were overweight and obese people shown in the second part of
the results is consistent with other published studies. Second, when analyzing the association
between MAP3K1 gene polymorphism and the risk of GC in the third part, whether to consider
the relationship between the number of bad alleles and the risk of GC? Finally, in the discussion
section, you listed the advantages and limitations of this study. I noticed that the sample
representativeness was not good (lines 290-292). This is a serious problem in my opinion,
which may affect the reliability and persuasiveness of the whole study and greatly reduce the
significance of the study.
Please review this paper.
user
Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 2 Date: 28 Aug 2022
Reviewer's report:
Gastric cancer is caused by the interaction of genes and environmental factors. The purpose of
this study is of great significance to analyze the risk of GC by combining gene polymorphism and
dietary factors. But there are a few questions I want answered. First, whether the significantly
lower GC risk in those who were overweight and obese people shown in the second part of
the results is consistent with other published studies. Second, when analyzing the association
between MAP3K1 gene polymorphism and the risk of GC in the third part, whether to consider
the relationship between the number of bad alleles and the risk of GC? Finally, in the discussion
section, you listed the advantages and limitations of this study. I noticed that the sample
representativeness was not good (lines 290-292). This is a serious problem in my opinion,
which may affect the reliability and persuasiveness of the whole study and greatly reduce the
significance of the study.
assistant