Title: Long Transparent Cap-Assisted Clip Closure Technique: A New Choice for
Gastrointestinal Defect Closure
Version: 2 Date: 08 Feb 2025
Reviewer:  Teppei Masunaga
Reviewer's report:
Thank you for allowing me to review the manuscript. You mentioned new closure technique. It
is unique and interesting. However, there are several concerns which should be considered.
1. How is the closure outcome of the LTCCC group before propensity scores matching? Were
the any dehiscence of the defect cases or long hospital stay cases or severe adverse events?
Comparison is important, but you should also show the feasibility of this new closure method
without adjusting the sample size.
2, Theoretically, this closure method can close the defect only in cases where the length between
the both side of the wound is less than the diameter of the distal attachment. The defect of the
cases presented in the video and figure was small. What is the indication of this method? How
large a defect can be closed by this method?
3. In this method, can large clip (width >10mm) be used? What is your recommendation about
the type of the clips.
4, How long is the length between the distal edge of the endoscope and the distal edge of the
attachment ?
5. What are the covariates for propensity scores matching? You should mention it in the statistics
section.
6. You mentioned “the protruding clip often pushes the wound mucosa further away,” in the
discussion session. I cannot understand the meaning of this sentence. Please explain that more
understandably?
Title: Long Transparent Cap-Assisted Clip Closure Technique: A New Choice for
Gastrointestinal Defect Closure
Version: 2 Date: 08 Feb 2025
Reviewer:  Teppei Masunaga
Reviewer's report:
Thank you for allowing me to review the manuscript. You mentioned new closure technique. It
is unique and interesting. However, there are several concerns which should be considered.
1. How is the closure outcome of the LTCCC group before propensity scores matching? Were
the any dehiscence of the defect cases or long hospital stay cases or severe adverse events?
Comparison is important, but you should also show the feasibility of this new closure method
without adjusting the sample size.
2, Theoretically, this closure method can close the defect only in cases where the length between
the both side of the wound is less than the diameter of the distal attachment. The defect of the
cases presented in the video and figure was small. What is the indication of this method? How
large a defect can be closed by this method?
3. In this method, can large clip (width >10mm) be used? What is your recommendation about
the type of the clips.
4, How long is the length between the distal edge of the endoscope and the distal edge of the
attachment ?
5. What are the covariates for propensity scores matching? You should mention it in the statistics
section.
6. You mentioned “the protruding clip often pushes the wound mucosa further away,” in the
discussion session. I cannot understand the meaning of this sentence. Please explain that more
understandably?
Please review this paper.
user
Title: Long Transparent Cap-Assisted Clip Closure Technique: A New Choice for
Gastrointestinal Defect Closure
Version: 2 Date: 08 Feb 2025
Reviewer:  Teppei Masunaga
Reviewer's report:
Thank you for allowing me to review the manuscript. You mentioned new closure technique. It
is unique and interesting. However, there are several concerns which should be considered.
1. How is the closure outcome of the LTCCC group before propensity scores matching? Were
the any dehiscence of the defect cases or long hospital stay cases or severe adverse events?
Comparison is important, but you should also show the feasibility of this new closure method
without adjusting the sample size.
2, Theoretically, this closure method can close the defect only in cases where the length between
the both side of the wound is less than the diameter of the distal attachment. The defect of the
cases presented in the video and figure was small. What is the indication of this method? How
large a defect can be closed by this method?
3. In this method, can large clip (width >10mm) be used? What is your recommendation about
the type of the clips.
4, How long is the length between the distal edge of the endoscope and the distal edge of the
attachment ?
5. What are the covariates for propensity scores matching? You should mention it in the statistics
section.
6. You mentioned “the protruding clip often pushes the wound mucosa further away,” in the
discussion session. I cannot understand the meaning of this sentence. Please explain that more
understandably?
assistant