Title: The Prevalence and Severity of Upper Gastrointestinal Complications among Patients
with Chronic Diseases: A Cross-Sectional Study from Palestine
Version: 2 Date: 15 Dec 2023
Reviewer:  Hani Naseef
Reviewer's report:
Introduction:
• The author mentioned: “Recent studies showed that the prevalence of dyspepsia associated
with aspirin”
Comment: Why is aspirin related to dyspepsia since this medicine is now available as enteric-
coated tablets? Need clarification
• The study aims to assess the prevalence : aimed to
• To the best of our knowledge, this study is the first of its type in Palestine:
Comment: A new paper was published; hopefully the author will take it into consideration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646118/
Material and methods:
• This study was conducted in Jenin city in the West Bank and included patients visiting
outpatient clinics in Ibn Sina hospital.
Comment: Why did the authors select this hospital and city? Does this sample really represent
all Palestinians? It's possible that the authors should retitle their manuscript. Additinaly need
clarifications for the city selection
• The clinics are for patients with internal diseases, and most of them are suffering from chronic
diseases
Comment: What percentage of patients have from chronic diseases ? need references also
• Comment: must address the  total population
• The inclusion criteria were as follows: males and females, confirmed diagnosis of chronic
diseases and using one or more chronic medications
•
Comment: Did the authors obtain these details from the patient's record?  And the age below
eighteen? If any, were they included in the study?
• Comment: Was the Dyspepsia Questionnaire delivered in Arabic or English? If in Arabic: Who
did the translation?
•
• Comment: Who participates in the data collection process?  Did they receive any training?
Results:
• Table 2: Table 2: The total number of patients with dyspepsia is 137 + 98 + 104 + 51 + 10
= 263 instead of 264. the same comment for the Heartburn. . Please check all of the numbers
in the tables.,
• Comment: Why did the authors not make associations between dyspepsia and diseases or
drugs?  Given that some illnesses and/or medications may have an impact on dyspepsia, I believe
it is crucial to make these associations.
Discussion:
More than 90% of participants reported having dyspepsia to some extent, according to the
authors. I believe that the discussion should have focused on the causes of these outcomes and
tried to explain these results in light of the findings of this study.
Title: The Prevalence and Severity of Upper Gastrointestinal Complications among Patients
with Chronic Diseases: A Cross-Sectional Study from Palestine
Version: 2 Date: 15 Dec 2023
Reviewer:  Hani Naseef
Reviewer's report:
Introduction:
• The author mentioned: “Recent studies showed that the prevalence of dyspepsia associated
with aspirin”
Comment: Why is aspirin related to dyspepsia since this medicine is now available as enteric-
coated tablets? Need clarification
• The study aims to assess the prevalence : aimed to
• To the best of our knowledge, this study is the first of its type in Palestine:
Comment: A new paper was published; hopefully the author will take it into consideration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646118/
Material and methods:
• This study was conducted in Jenin city in the West Bank and included patients visiting
outpatient clinics in Ibn Sina hospital.
Comment: Why did the authors select this hospital and city? Does this sample really represent
all Palestinians? It's possible that the authors should retitle their manuscript. Additinaly need
clarifications for the city selection
• The clinics are for patients with internal diseases, and most of them are suffering from chronic
diseases
Comment: What percentage of patients have from chronic diseases ? need references also
• Comment: must address the  total population
• The inclusion criteria were as follows: males and females, confirmed diagnosis of chronic
diseases and using one or more chronic medications
•
Comment: Did the authors obtain these details from the patient's record?  And the age below
eighteen? If any, were they included in the study?
• Comment: Was the Dyspepsia Questionnaire delivered in Arabic or English? If in Arabic: Who
did the translation?
•
• Comment: Who participates in the data collection process?  Did they receive any training?
Results:
• Table 2: Table 2: The total number of patients with dyspepsia is 137 + 98 + 104 + 51 + 10
= 263 instead of 264. the same comment for the Heartburn. . Please check all of the numbers
in the tables.,
• Comment: Why did the authors not make associations between dyspepsia and diseases or
drugs?  Given that some illnesses and/or medications may have an impact on dyspepsia, I believe
it is crucial to make these associations.
Discussion:
More than 90% of participants reported having dyspepsia to some extent, according to the
authors. I believe that the discussion should have focused on the causes of these outcomes and
tried to explain these results in light of the findings of this study.
Please review this paper.
user
Title: The Prevalence and Severity of Upper Gastrointestinal Complications among Patients
with Chronic Diseases: A Cross-Sectional Study from Palestine
Version: 2 Date: 15 Dec 2023
Reviewer:  Hani Naseef
Reviewer's report:
Introduction:
• The author mentioned: “Recent studies showed that the prevalence of dyspepsia associated
with aspirin”
Comment: Why is aspirin related to dyspepsia since this medicine is now available as enteric-
coated tablets? Need clarification
• The study aims to assess the prevalence : aimed to
• To the best of our knowledge, this study is the first of its type in Palestine:
Comment: A new paper was published; hopefully the author will take it into consideration.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10646118/
Material and methods:
• This study was conducted in Jenin city in the West Bank and included patients visiting
outpatient clinics in Ibn Sina hospital.
Comment: Why did the authors select this hospital and city? Does this sample really represent
all Palestinians? It's possible that the authors should retitle their manuscript. Additinaly need
clarifications for the city selection
• The clinics are for patients with internal diseases, and most of them are suffering from chronic
diseases
Comment: What percentage of patients have from chronic diseases ? need references also
• Comment: must address the  total population
• The inclusion criteria were as follows: males and females, confirmed diagnosis of chronic
diseases and using one or more chronic medications
•
Comment: Did the authors obtain these details from the patient's record?  And the age below
eighteen? If any, were they included in the study?
• Comment: Was the Dyspepsia Questionnaire delivered in Arabic or English? If in Arabic: Who
did the translation?
•
• Comment: Who participates in the data collection process?  Did they receive any training?
Results:
• Table 2: Table 2: The total number of patients with dyspepsia is 137 + 98 + 104 + 51 + 10
= 263 instead of 264. the same comment for the Heartburn. . Please check all of the numbers
in the tables.,
• Comment: Why did the authors not make associations between dyspepsia and diseases or
drugs?  Given that some illnesses and/or medications may have an impact on dyspepsia, I believe
it is crucial to make these associations.
Discussion:
More than 90% of participants reported having dyspepsia to some extent, according to the
authors. I believe that the discussion should have focused on the causes of these outcomes and
tried to explain these results in light of the findings of this study.
assistant