Title: Inflammatory Biomarker Correlations and Prognosis in High-risk Gastrointestinal
Stromal Tumor Patients: A Multicenter Retrospective Analysis
Version: 4 Date: 27 Dec 2024
Reviewer:  Tsunehiko Maruyama
Reviewer's report:
The authors changed the method for determining the cut-off value from the median to using
the ROC curve, and reported preoperative PNI and postoperative imatinib administration as
independent prognostic factors.
It is not a new finding that preoperative PNI is a prognostic factor in various cancers, but it is
worth evaluating that this study only included high-risk GIST cases.
Therefore, it is necessary to describe in detail the criteria used to select cases that received
postoperative imatinib and those that did not.
Preoperative PNI is said to reflect inflammatory conditions rather than just the patient's
nutritional status. This point should be mentioned in the discussion.
Title: Inflammatory Biomarker Correlations and Prognosis in High-risk Gastrointestinal
Stromal Tumor Patients: A Multicenter Retrospective Analysis
Version: 4 Date: 27 Dec 2024
Reviewer:  Tsunehiko Maruyama
Reviewer's report:
The authors changed the method for determining the cut-off value from the median to using
the ROC curve, and reported preoperative PNI and postoperative imatinib administration as
independent prognostic factors.
It is not a new finding that preoperative PNI is a prognostic factor in various cancers, but it is
worth evaluating that this study only included high-risk GIST cases.
Therefore, it is necessary to describe in detail the criteria used to select cases that received
postoperative imatinib and those that did not.
Preoperative PNI is said to reflect inflammatory conditions rather than just the patient's
nutritional status. This point should be mentioned in the discussion.
Please review this paper.
user
Title: Inflammatory Biomarker Correlations and Prognosis in High-risk Gastrointestinal
Stromal Tumor Patients: A Multicenter Retrospective Analysis
Version: 4 Date: 27 Dec 2024
Reviewer:  Tsunehiko Maruyama
Reviewer's report:
The authors changed the method for determining the cut-off value from the median to using
the ROC curve, and reported preoperative PNI and postoperative imatinib administration as
independent prognostic factors.
It is not a new finding that preoperative PNI is a prognostic factor in various cancers, but it is
worth evaluating that this study only included high-risk GIST cases.
Therefore, it is necessary to describe in detail the criteria used to select cases that received
postoperative imatinib and those that did not.
Preoperative PNI is said to reflect inflammatory conditions rather than just the patient's
nutritional status. This point should be mentioned in the discussion.
assistant