Reviewer ’s report  
 
Title: Molecular and serologic characterization of rotavirus from children with acute  
gastroenteritis in Northern Iran, Gorgan  
 
Version: 0 Date: 08 May 2019  
 
Reviewer: Hsu-Heng Yen  
 
Reviewer's report:  
 
Dear Editor  
 
This is an interesting article describe the update data about rotavirus infection in Iran.  
 
#1. Article Line 276. One of the most importa nt challenges for future rotavirus 277 vaccine is 
absence of epidemiological studies and sufficient information about geographical 278 
distribution of different human rotavirus strains. A recent publication ( An meta -analysis for 
rotavirus infection was pu blished in 2017 (  Epidemiology of Rotavirus in the Iranian Children: 
A Systematic Review and Meta -analysis  
 
J Glob Infect Dis. 2017 Apr -Jun; 9(2): 66 -7 ) reported different distribution of rotavirus infection 
infection even in Iran. Please address this iss ue in the discussion and provide discussion about 
geographic variation of Iran rotavirus infection  
 
Are the methods appropriate and well described?  
If not, please spe cify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data show n? 
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be include d 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as  confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Molecular and serologic characterization of rotavirus from children with acute  
gastroenteritis in Northern Iran, Gorgan  
 
Version: 0 Date: 08 May 2019  
 
Reviewer: Hsu-Heng Yen  
 
Reviewer's report:  
 
Dear Editor  
 
This is an interesting article describe the update data about rotavirus infection in Iran.  
 
#1. Article Line 276. One of the most importa nt challenges for future rotavirus 277 vaccine is 
absence of epidemiological studies and sufficient information about geographical 278 
distribution of different human rotavirus strains. A recent publication ( An meta -analysis for 
rotavirus infection was pu blished in 2017 (  Epidemiology of Rotavirus in the Iranian Children: 
A Systematic Review and Meta -analysis  
 
J Glob Infect Dis. 2017 Apr -Jun; 9(2): 66 -7 ) reported different distribution of rotavirus infection 
infection even in Iran. Please address this iss ue in the discussion and provide discussion about 
geographic variation of Iran rotavirus infection  
 
Are the methods appropriate and well described?  
If not, please spe cify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data show n? 
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be include d 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as  confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Molecular and serologic characterization of rotavirus from children with acute  
gastroenteritis in Northern Iran, Gorgan  
 
Version: 0 Date: 08 May 2019  
 
Reviewer: Hsu-Heng Yen  
 
Reviewer's report:  
 
Dear Editor  
 
This is an interesting article describe the update data about rotavirus infection in Iran.  
 
#1. Article Line 276. One of the most importa nt challenges for future rotavirus 277 vaccine is 
absence of epidemiological studies and sufficient information about geographical 278 
distribution of different human rotavirus strains. A recent publication ( An meta -analysis for 
rotavirus infection was pu blished in 2017 (  Epidemiology of Rotavirus in the Iranian Children: 
A Systematic Review and Meta -analysis  
 
J Glob Infect Dis. 2017 Apr -Jun; 9(2): 66 -7 ) reported different distribution of rotavirus infection 
infection even in Iran. Please address this iss ue in the discussion and provide discussion about 
geographic variation of Iran rotavirus infection  
 
Are the methods appropriate and well described?  
If not, please spe cify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data show n? 
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
None  
 
I agree to the open peer review policy of the journal. I understand that my name will be include d 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as  confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant