Reviewer's report
Title:1 MAC Isoflurane Preconditioning Induce Protective Effects of Heme
oxygenase-1 on Hepatic Ischemia Reperfusion in Rats
Version: 1Date:17 May 2010
Reviewer: Holger K Eltzschig
Reviewer's report:
In the present study, Win Lv and co-authors investigate the role of
preconditioning with isoflurane on Heme oxygenase 1-dependent liver protection
during ischemia reperfusion injury.
Major comments:
1.) The authors need to include arterial blood pressure values for both groups. I
suspect that the induction and HO-1 protection are induced by
hypotension/ischemia - like ischemic preconditioning - by isoflurane induced
decrease in blood pressure.
2.) The authors need to provide genetic evidence for a role of HO-1 in their
responses.
3.) The paper needs to be re-written in better English.
Reviewer's report
Title:1 MAC Isoflurane Preconditioning Induce Protective Effects of Heme
oxygenase-1 on Hepatic Ischemia Reperfusion in Rats
Version: 1Date:17 May 2010
Reviewer: Holger K Eltzschig
Reviewer's report:
In the present study, Win Lv and co-authors investigate the role of
preconditioning with isoflurane on Heme oxygenase 1-dependent liver protection
during ischemia reperfusion injury.
Major comments:
1.) The authors need to include arterial blood pressure values for both groups. I
suspect that the induction and HO-1 protection are induced by
hypotension/ischemia - like ischemic preconditioning - by isoflurane induced
decrease in blood pressure.
2.) The authors need to provide genetic evidence for a role of HO-1 in their
responses.
3.) The paper needs to be re-written in better English.
Please review this paper.
user
Reviewer's report
Title:1 MAC Isoflurane Preconditioning Induce Protective Effects of Heme
oxygenase-1 on Hepatic Ischemia Reperfusion in Rats
Version: 1Date:17 May 2010
Reviewer: Holger K Eltzschig
Reviewer's report:
In the present study, Win Lv and co-authors investigate the role of
preconditioning with isoflurane on Heme oxygenase 1-dependent liver protection
during ischemia reperfusion injury.
Major comments:
1.) The authors need to include arterial blood pressure values for both groups. I
suspect that the induction and HO-1 protection are induced by
hypotension/ischemia - like ischemic preconditioning - by isoflurane induced
decrease in blood pressure.
2.) The authors need to provide genetic evidence for a role of HO-1 in their
responses.
3.) The paper needs to be re-written in better English.
assistant