Title: Methylated septin 9 gene is an important prognostic marker in stage II and stage III
colorectal cancer for evaluating local recurrence or distant metastasis after surgery
Version: 1 Date: 16 Dec 2021
Reviewer's report:
I am very honored to be peer-reviewed this time. This study shows that the Methylated septin
9 gene may be a prognostic factor in post-curative Stage II and III colorectal cancer cases.
Interesting results, but with some questions.
Major comment)
What are the details of the located areas of colon cancer?
What are the details of the surgical procedure for rectal cancer cases?
I would like to know the CRM status in rectal cancer cases.
How do you interpret that there is a significant difference between the T stage and the M stage,
but not the N stage?
How do you interpret the high number of positives in the lower rectum?
Minor comment)
Are there cases of lateral lymph node metastasis in rectal cancer cases? How many cases have
had lateral lymph node dissection?
Title: Methylated septin 9 gene is an important prognostic marker in stage II and stage III
colorectal cancer for evaluating local recurrence or distant metastasis after surgery
Version: 1 Date: 16 Dec 2021
Reviewer's report:
I am very honored to be peer-reviewed this time. This study shows that the Methylated septin
9 gene may be a prognostic factor in post-curative Stage II and III colorectal cancer cases.
Interesting results, but with some questions.
Major comment)
What are the details of the located areas of colon cancer?
What are the details of the surgical procedure for rectal cancer cases?
I would like to know the CRM status in rectal cancer cases.
How do you interpret that there is a significant difference between the T stage and the M stage,
but not the N stage?
How do you interpret the high number of positives in the lower rectum?
Minor comment)
Are there cases of lateral lymph node metastasis in rectal cancer cases? How many cases have
had lateral lymph node dissection?
Please review this paper.
user
Title: Methylated septin 9 gene is an important prognostic marker in stage II and stage III
colorectal cancer for evaluating local recurrence or distant metastasis after surgery
Version: 1 Date: 16 Dec 2021
Reviewer's report:
I am very honored to be peer-reviewed this time. This study shows that the Methylated septin
9 gene may be a prognostic factor in post-curative Stage II and III colorectal cancer cases.
Interesting results, but with some questions.
Major comment)
What are the details of the located areas of colon cancer?
What are the details of the surgical procedure for rectal cancer cases?
I would like to know the CRM status in rectal cancer cases.
How do you interpret that there is a significant difference between the T stage and the M stage,
but not the N stage?
How do you interpret the high number of positives in the lower rectum?
Minor comment)
Are there cases of lateral lymph node metastasis in rectal cancer cases? How many cases have
had lateral lymph node dissection?
assistant