Title: Assessing the longitudinal association between the GGT/HDL-C ratio and NAFLD: a
cohort study in a non-obese Chinese population
Version: 0 Date: 18 Oct 2022
Reviewer's report:
In this manuscript titled “Assessing the longitudinal association between the GGT/HDL-C ratio
and NAFLD: a cohort study in a non-obese Chinese population", authors present the findings
of their longitudinal study exploring the relationship between the ratio of GGT to HDL-C
and NAFLD in a cohort of non-obese Chinese individuals. They report a positive association
between GGT/HDL-C ratio and NAFLD risk. Furthermore, GGT/HDL-C ratio had a nonlinear
relationship with NAFLD. The paper overall is well written. The findings are of interest,
supporting the importance of the GGT/HDL-C ratio in determining NAFLD risk.
1. Since the recent research focuses on HDL functionality than just HDL-C levels, it would be
more informative if the authors discussed the HDL functions and their role in predicting the risk
of NAFLD in the discussion section.
2. Since insulin resistance is a universal finding in NAFLD, it would be interesting to see if
the insulin resistance markers (e.g., HOMA-IR) could influence the association between GGT/
HDL-C ratio and NAFLD using a stratified association as in Table 3.
3. The dataset is not accessible through the link provided in the manuscript.
Title: Assessing the longitudinal association between the GGT/HDL-C ratio and NAFLD: a
cohort study in a non-obese Chinese population
Version: 0 Date: 18 Oct 2022
Reviewer's report:
In this manuscript titled “Assessing the longitudinal association between the GGT/HDL-C ratio
and NAFLD: a cohort study in a non-obese Chinese population", authors present the findings
of their longitudinal study exploring the relationship between the ratio of GGT to HDL-C
and NAFLD in a cohort of non-obese Chinese individuals. They report a positive association
between GGT/HDL-C ratio and NAFLD risk. Furthermore, GGT/HDL-C ratio had a nonlinear
relationship with NAFLD. The paper overall is well written. The findings are of interest,
supporting the importance of the GGT/HDL-C ratio in determining NAFLD risk.
1. Since the recent research focuses on HDL functionality than just HDL-C levels, it would be
more informative if the authors discussed the HDL functions and their role in predicting the risk
of NAFLD in the discussion section.
2. Since insulin resistance is a universal finding in NAFLD, it would be interesting to see if
the insulin resistance markers (e.g., HOMA-IR) could influence the association between GGT/
HDL-C ratio and NAFLD using a stratified association as in Table 3.
3. The dataset is not accessible through the link provided in the manuscript.
Please review this paper.
user
Title: Assessing the longitudinal association between the GGT/HDL-C ratio and NAFLD: a
cohort study in a non-obese Chinese population
Version: 0 Date: 18 Oct 2022
Reviewer's report:
In this manuscript titled “Assessing the longitudinal association between the GGT/HDL-C ratio
and NAFLD: a cohort study in a non-obese Chinese population", authors present the findings
of their longitudinal study exploring the relationship between the ratio of GGT to HDL-C
and NAFLD in a cohort of non-obese Chinese individuals. They report a positive association
between GGT/HDL-C ratio and NAFLD risk. Furthermore, GGT/HDL-C ratio had a nonlinear
relationship with NAFLD. The paper overall is well written. The findings are of interest,
supporting the importance of the GGT/HDL-C ratio in determining NAFLD risk.
1. Since the recent research focuses on HDL functionality than just HDL-C levels, it would be
more informative if the authors discussed the HDL functions and their role in predicting the risk
of NAFLD in the discussion section.
2. Since insulin resistance is a universal finding in NAFLD, it would be interesting to see if
the insulin resistance markers (e.g., HOMA-IR) could influence the association between GGT/
HDL-C ratio and NAFLD using a stratified association as in Table 3.
3. The dataset is not accessible through the link provided in the manuscript.
assistant