Title: Triglyceride Glucose-Waist Circumference: The Optimum Index to Screen Nonalcoholic
Fatty Liver Disease in Non-obese Adults
Version: 1 Date: 12 Jun 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a ""classically"" executed NHANES secondary analysis
study aimed to find non-invasive biomarkers of NAFLD in non-obese populations. Study is
correctly designed and executed. There is one principal weakness in this study as it does not
compare performance of a proposed marker with other minimally invasive and validated markers
available in NHANES data (for example, but not limited to APRI)
REQUESTED REVISIONS:
Authors should augment their MS with a performance comparison for other known ""simple""
biomarkers of NAFLD (like APRI, etc.). Also, thorough proofreading in needed. More detailed
discussion concerning very high percent of Fibroscan NAFLD in NHANES cohort of non-obese
should be discussed. Differentiation with AFLD may be needed. Was it discussed in the literature
earlier? If so, need refs and explanations."
Title: Triglyceride Glucose-Waist Circumference: The Optimum Index to Screen Nonalcoholic
Fatty Liver Disease in Non-obese Adults
Version: 1 Date: 12 Jun 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a ""classically"" executed NHANES secondary analysis
study aimed to find non-invasive biomarkers of NAFLD in non-obese populations. Study is
correctly designed and executed. There is one principal weakness in this study as it does not
compare performance of a proposed marker with other minimally invasive and validated markers
available in NHANES data (for example, but not limited to APRI)
REQUESTED REVISIONS:
Authors should augment their MS with a performance comparison for other known ""simple""
biomarkers of NAFLD (like APRI, etc.). Also, thorough proofreading in needed. More detailed
discussion concerning very high percent of Fibroscan NAFLD in NHANES cohort of non-obese
should be discussed. Differentiation with AFLD may be needed. Was it discussed in the literature
earlier? If so, need refs and explanations."
Please review this paper.
user
Title: Triglyceride Glucose-Waist Circumference: The Optimum Index to Screen Nonalcoholic
Fatty Liver Disease in Non-obese Adults
Version: 1 Date: 12 Jun 2023
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a ""classically"" executed NHANES secondary analysis
study aimed to find non-invasive biomarkers of NAFLD in non-obese populations. Study is
correctly designed and executed. There is one principal weakness in this study as it does not
compare performance of a proposed marker with other minimally invasive and validated markers
available in NHANES data (for example, but not limited to APRI)
REQUESTED REVISIONS:
Authors should augment their MS with a performance comparison for other known ""simple""
biomarkers of NAFLD (like APRI, etc.). Also, thorough proofreading in needed. More detailed
discussion concerning very high percent of Fibroscan NAFLD in NHANES cohort of non-obese
should be discussed. Differentiation with AFLD may be needed. Was it discussed in the literature
earlier? If so, need refs and explanations."
assistant