Title: Variations in the gastric mucosal microbiome and its predictive functions between
chronic atrophic gastritis and chronic nonatrophic gastritis patients based on Helicobacter pylori
negativity (A study of variations in the gastric mucosal microbiome)
Version: 1 Date: 14 Feb 2025
Reviewer's report:
Authors of the manuscript presents    results of interesting and significant study,  in particular
from methodical point  of view . On the other hand , considering the multifactor impact on
human microbiome,   evaluation of the results   and  the conclusion should be balanced if
group of patient from one hospital only is analysed. Authors  state that bacteria other than Hp
cause the inflammation  but they should consider also  that inflammation may facilitate bacterial
colonisation  due  to reduction release of H+ ions
Anyway,  the concept,    methodology  and structure of manuscript  is correct and I only address
some minor remarks listed below
• Line 170: the phrase “bacterial variation”  is as not clear enough and as the result confusing
• Or line 190  the phrase “ bacterial  correlation”  is confusing as well .   What is corelated?  -
in my opinion “coincidence „should be used instead
• Line  200, 203 “We observed alterations in the metabolism and signal transduction of gastric”
this attitude not mentioned in the description of methods
• Information  from introduction (line 50-52) is repeated in discussion (line 214)
Title: Variations in the gastric mucosal microbiome and its predictive functions between
chronic atrophic gastritis and chronic nonatrophic gastritis patients based on Helicobacter pylori
negativity (A study of variations in the gastric mucosal microbiome)
Version: 1 Date: 14 Feb 2025
Reviewer's report:
Authors of the manuscript presents    results of interesting and significant study,  in particular
from methodical point  of view . On the other hand , considering the multifactor impact on
human microbiome,   evaluation of the results   and  the conclusion should be balanced if
group of patient from one hospital only is analysed. Authors  state that bacteria other than Hp
cause the inflammation  but they should consider also  that inflammation may facilitate bacterial
colonisation  due  to reduction release of H+ ions
Anyway,  the concept,    methodology  and structure of manuscript  is correct and I only address
some minor remarks listed below
• Line 170: the phrase “bacterial variation”  is as not clear enough and as the result confusing
• Or line 190  the phrase “ bacterial  correlation”  is confusing as well .   What is corelated?  -
in my opinion “coincidence „should be used instead
• Line  200, 203 “We observed alterations in the metabolism and signal transduction of gastric”
this attitude not mentioned in the description of methods
• Information  from introduction (line 50-52) is repeated in discussion (line 214)
Please review this paper.
user
Title: Variations in the gastric mucosal microbiome and its predictive functions between
chronic atrophic gastritis and chronic nonatrophic gastritis patients based on Helicobacter pylori
negativity (A study of variations in the gastric mucosal microbiome)
Version: 1 Date: 14 Feb 2025
Reviewer's report:
Authors of the manuscript presents    results of interesting and significant study,  in particular
from methodical point  of view . On the other hand , considering the multifactor impact on
human microbiome,   evaluation of the results   and  the conclusion should be balanced if
group of patient from one hospital only is analysed. Authors  state that bacteria other than Hp
cause the inflammation  but they should consider also  that inflammation may facilitate bacterial
colonisation  due  to reduction release of H+ ions
Anyway,  the concept,    methodology  and structure of manuscript  is correct and I only address
some minor remarks listed below
• Line 170: the phrase “bacterial variation”  is as not clear enough and as the result confusing
• Or line 190  the phrase “ bacterial  correlation”  is confusing as well .   What is corelated?  -
in my opinion “coincidence „should be used instead
• Line  200, 203 “We observed alterations in the metabolism and signal transduction of gastric”
this attitude not mentioned in the description of methods
• Information  from introduction (line 50-52) is repeated in discussion (line 214)
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