Reviewer ’s report  
 
Title: A combination of single -balloon enteroscopy -assisted lap aroscopy and endoscopic 
mucosal resection for treating gastrointestinal venous malformations in blue rubber bleb nev us 
syndrome: A case report  
 
Version: 0 Date: 25 Mar 2020  
 
Reviewer: Kinichi Hotta  
 
Reviewer's report:  
 
Dr. Xu Y et al. reported a case of BRBRS with multiple GI malformations. They described the 
patient were suc cessfully treated by SBE assisted laparoscopy and EMR. There are some 
question about a manuscripts.  
 
 
Comments:  
 
1) What is SBE assisted laparoscopy? Was it intraoperative enteroscopy? How did they 
treat small intestine lesions, only EMR, or partial resectio n of small intestine? Please 
explain detail of procedure.  
 
2) Were these lesions treated by EMRs by a single session?  
 
3) Did they try SBE without laparoscopy? Laparoscopy seemed not minimal -invasive.  
 
4) Please shorten discussion section. I think description  about therapeutic method is most 
important.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to thi s manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering t he following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you h old any stocks or shares in an organisation that may in any way gain or 
lose financia lly from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the websi te along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my name d report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: A combination of single -balloon enteroscopy -assisted lap aroscopy and endoscopic 
mucosal resection for treating gastrointestinal venous malformations in blue rubber bleb nev us 
syndrome: A case report  
 
Version: 0 Date: 25 Mar 2020  
 
Reviewer: Kinichi Hotta  
 
Reviewer's report:  
 
Dr. Xu Y et al. reported a case of BRBRS with multiple GI malformations. They described the 
patient were suc cessfully treated by SBE assisted laparoscopy and EMR. There are some 
question about a manuscripts.  
 
 
Comments:  
 
1) What is SBE assisted laparoscopy? Was it intraoperative enteroscopy? How did they 
treat small intestine lesions, only EMR, or partial resectio n of small intestine? Please 
explain detail of procedure.  
 
2) Were these lesions treated by EMRs by a single session?  
 
3) Did they try SBE without laparoscopy? Laparoscopy seemed not minimal -invasive.  
 
4) Please shorten discussion section. I think description  about therapeutic method is most 
important.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to thi s manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering t he following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you h old any stocks or shares in an organisation that may in any way gain or 
lose financia lly from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the websi te along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my name d report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: A combination of single -balloon enteroscopy -assisted lap aroscopy and endoscopic 
mucosal resection for treating gastrointestinal venous malformations in blue rubber bleb nev us 
syndrome: A case report  
 
Version: 0 Date: 25 Mar 2020  
 
Reviewer: Kinichi Hotta  
 
Reviewer's report:  
 
Dr. Xu Y et al. reported a case of BRBRS with multiple GI malformations. They described the 
patient were suc cessfully treated by SBE assisted laparoscopy and EMR. There are some 
question about a manuscripts.  
 
 
Comments:  
 
1) What is SBE assisted laparoscopy? Was it intraoperative enteroscopy? How did they 
treat small intestine lesions, only EMR, or partial resectio n of small intestine? Please 
explain detail of procedure.  
 
2) Were these lesions treated by EMRs by a single session?  
 
3) Did they try SBE without laparoscopy? Laparoscopy seemed not minimal -invasive.  
 
4) Please shorten discussion section. I think description  about therapeutic method is most 
important.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to thi s manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering t he following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you h old any stocks or shares in an organisation that may in any way gain or 
lose financia lly from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the websi te along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my name d report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant