Reviewer's report
Title:The Prevalence, Incidence and Natural History of Primary Sclerosing
Cholangitis in an Ethnically Diverse Population
Version: 1Date:14 June 2011
Reviewer: Timothy Card
Reviewer's report:
This is a nicely written report of what seems to me a well conducted study in a
dataset appropriate to the questions it seeks to answer. I have no major
concerns regarding it.
Discretionary Revisions
Though I appreciate that the authors have sought to place their work in most
regards in the mainstream in this subject, I think they have underplayed the
differences somewhat. This is as they point out the second recent population
based study of a large unselected population to find that PSC is rarer than stated
by some enthusiasts. It would appear to me that another departure of both these
studies is that they have found lower rates of IBD in PSC than often stated.
Precisely how this should be interpreted is open to debate, as it would imply
either that the more selected populations are atypical in having so much IBD, or
that in the generality of cases IBD is under diagnosed. I would have welcomed
more discussion around this point.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:The Prevalence, Incidence and Natural History of Primary Sclerosing
Cholangitis in an Ethnically Diverse Population
Version: 1Date:14 June 2011
Reviewer: Timothy Card
Reviewer's report:
This is a nicely written report of what seems to me a well conducted study in a
dataset appropriate to the questions it seeks to answer. I have no major
concerns regarding it.
Discretionary Revisions
Though I appreciate that the authors have sought to place their work in most
regards in the mainstream in this subject, I think they have underplayed the
differences somewhat. This is as they point out the second recent population
based study of a large unselected population to find that PSC is rarer than stated
by some enthusiasts. It would appear to me that another departure of both these
studies is that they have found lower rates of IBD in PSC than often stated.
Precisely how this should be interpreted is open to debate, as it would imply
either that the more selected populations are atypical in having so much IBD, or
that in the generality of cases IBD is under diagnosed. I would have welcomed
more discussion around this point.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:The Prevalence, Incidence and Natural History of Primary Sclerosing
Cholangitis in an Ethnically Diverse Population
Version: 1Date:14 June 2011
Reviewer: Timothy Card
Reviewer's report:
This is a nicely written report of what seems to me a well conducted study in a
dataset appropriate to the questions it seeks to answer. I have no major
concerns regarding it.
Discretionary Revisions
Though I appreciate that the authors have sought to place their work in most
regards in the mainstream in this subject, I think they have underplayed the
differences somewhat. This is as they point out the second recent population
based study of a large unselected population to find that PSC is rarer than stated
by some enthusiasts. It would appear to me that another departure of both these
studies is that they have found lower rates of IBD in PSC than often stated.
Precisely how this should be interpreted is open to debate, as it would imply
either that the more selected populations are atypical in having so much IBD, or
that in the generality of cases IBD is under diagnosed. I would have welcomed
more discussion around this point.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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