Title: Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease: A Bidirectional
Mendelian Randomization Study
Version: 0 Date: 13 Aug 2024
Reviewer's report:
The manuscript titled "Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease:
A Bidirectional Mendelian Randomization Study" by Hang Lei et al. evaluates the genetic
influences of plasma lipids on IBD risk using Mendelian randomization (MR) analysis. For this
manuscript, I have the following comments:
1. The authors should provide detailed information about the instrumental variables, including
their p-values in the IBD GWAS data, to assess whether assumption 3 is valid.
2. For the p-values of the MR results, the authors should provide both the original and corrected
p-values.
3. Some results exhibit pleiotropy; the authors should discuss the potential impact of pleiotropy
on the study findings.
4. Dysregulation of the lipidome may lead to intestinal inflammation, thereby triggering
endoplasmic reticulum stress, which could play a crucial role in the process of mucosal damage.
Previous studies have also indicated a relationship between endoplasmic reticulum stress
and IBD (refer to the following articles: DOI: 10.1016/j.yexcr.2023.113472; DOI: 10.3389/
fgene.2023.1270085). Could the authors further discuss the potential mechanisms linking
lipidome dysregulation, endoplasmic reticulum stress, and mucosal damage, and suggest future
research directions?
5.Discuss the implications of the findings and their relevance for public health recommendations
regarding IBD prevention.
Title: Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease: A Bidirectional
Mendelian Randomization Study
Version: 0 Date: 13 Aug 2024
Reviewer's report:
The manuscript titled "Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease:
A Bidirectional Mendelian Randomization Study" by Hang Lei et al. evaluates the genetic
influences of plasma lipids on IBD risk using Mendelian randomization (MR) analysis. For this
manuscript, I have the following comments:
1. The authors should provide detailed information about the instrumental variables, including
their p-values in the IBD GWAS data, to assess whether assumption 3 is valid.
2. For the p-values of the MR results, the authors should provide both the original and corrected
p-values.
3. Some results exhibit pleiotropy; the authors should discuss the potential impact of pleiotropy
on the study findings.
4. Dysregulation of the lipidome may lead to intestinal inflammation, thereby triggering
endoplasmic reticulum stress, which could play a crucial role in the process of mucosal damage.
Previous studies have also indicated a relationship between endoplasmic reticulum stress
and IBD (refer to the following articles: DOI: 10.1016/j.yexcr.2023.113472; DOI: 10.3389/
fgene.2023.1270085). Could the authors further discuss the potential mechanisms linking
lipidome dysregulation, endoplasmic reticulum stress, and mucosal damage, and suggest future
research directions?
5.Discuss the implications of the findings and their relevance for public health recommendations
regarding IBD prevention.
Please review this paper.
user
Title: Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease: A Bidirectional
Mendelian Randomization Study
Version: 0 Date: 13 Aug 2024
Reviewer's report:
The manuscript titled "Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease:
A Bidirectional Mendelian Randomization Study" by Hang Lei et al. evaluates the genetic
influences of plasma lipids on IBD risk using Mendelian randomization (MR) analysis. For this
manuscript, I have the following comments:
1. The authors should provide detailed information about the instrumental variables, including
their p-values in the IBD GWAS data, to assess whether assumption 3 is valid.
2. For the p-values of the MR results, the authors should provide both the original and corrected
p-values.
3. Some results exhibit pleiotropy; the authors should discuss the potential impact of pleiotropy
on the study findings.
4. Dysregulation of the lipidome may lead to intestinal inflammation, thereby triggering
endoplasmic reticulum stress, which could play a crucial role in the process of mucosal damage.
Previous studies have also indicated a relationship between endoplasmic reticulum stress
and IBD (refer to the following articles: DOI: 10.1016/j.yexcr.2023.113472; DOI: 10.3389/
fgene.2023.1270085). Could the authors further discuss the potential mechanisms linking
lipidome dysregulation, endoplasmic reticulum stress, and mucosal damage, and suggest future
research directions?
5.Discuss the implications of the findings and their relevance for public health recommendations
regarding IBD prevention.
assistant