Title: Significance and Clinical Utility of Targeted Metabolomic Analysis of Serum Bile Acid
Profiles for Early Diagnosis of Patients with Acute Pancreatitis
Version: 1 Date: 16 Dec 2024
Reviewer's report:
Using metabolomics research methods to search for biomarkers of acute pancreatitis is a valuable
endeavor. However, there are some important issues that the authors need to address.
1.Clinical studies should first consider multicenter, large sample size to ensure the validity of
the results. The author used only 150 clinical samples from one hospital. How reliable are the
study results?
2.More clinical information from the 150 clinical samples should be presented, especially
information such as imaging.
3.Quality control should be included in the study results to indicate the reliability of the results.
4.Figure 2 and Table 1 are the same batch of data and there is no need for a double presentation.
5.Detectors for metabolomics are generally serum, urine, and tissue, etc. Considering that the
goal of this study is to find biomarkers that may provide a scientific reference for non-invasive
diagnosis at a later stage, would it have been better to choose to test urine?
6.Figure quality is too poor, improve the clarity of the figure.
7.The article is crudely written with many formatting issues, while the language should be
revised.
Title: Significance and Clinical Utility of Targeted Metabolomic Analysis of Serum Bile Acid
Profiles for Early Diagnosis of Patients with Acute Pancreatitis
Version: 1 Date: 16 Dec 2024
Reviewer's report:
Using metabolomics research methods to search for biomarkers of acute pancreatitis is a valuable
endeavor. However, there are some important issues that the authors need to address.
1.Clinical studies should first consider multicenter, large sample size to ensure the validity of
the results. The author used only 150 clinical samples from one hospital. How reliable are the
study results?
2.More clinical information from the 150 clinical samples should be presented, especially
information such as imaging.
3.Quality control should be included in the study results to indicate the reliability of the results.
4.Figure 2 and Table 1 are the same batch of data and there is no need for a double presentation.
5.Detectors for metabolomics are generally serum, urine, and tissue, etc. Considering that the
goal of this study is to find biomarkers that may provide a scientific reference for non-invasive
diagnosis at a later stage, would it have been better to choose to test urine?
6.Figure quality is too poor, improve the clarity of the figure.
7.The article is crudely written with many formatting issues, while the language should be
revised.
Please review this paper.
user
Title: Significance and Clinical Utility of Targeted Metabolomic Analysis of Serum Bile Acid
Profiles for Early Diagnosis of Patients with Acute Pancreatitis
Version: 1 Date: 16 Dec 2024
Reviewer's report:
Using metabolomics research methods to search for biomarkers of acute pancreatitis is a valuable
endeavor. However, there are some important issues that the authors need to address.
1.Clinical studies should first consider multicenter, large sample size to ensure the validity of
the results. The author used only 150 clinical samples from one hospital. How reliable are the
study results?
2.More clinical information from the 150 clinical samples should be presented, especially
information such as imaging.
3.Quality control should be included in the study results to indicate the reliability of the results.
4.Figure 2 and Table 1 are the same batch of data and there is no need for a double presentation.
5.Detectors for metabolomics are generally serum, urine, and tissue, etc. Considering that the
goal of this study is to find biomarkers that may provide a scientific reference for non-invasive
diagnosis at a later stage, would it have been better to choose to test urine?
6.Figure quality is too poor, improve the clarity of the figure.
7.The article is crudely written with many formatting issues, while the language should be
revised.
assistant