Title: Serum and Salivary Tissue Transglutaminase IGA (tTG-IGA) Level in Celiac Patients
Version: 1 Date: 09 Jun 2022
Reviewer's report:
I suggest to use CD after the first time Celiac Disease has been quoted.
Why did the authors use pediatric diagnostic criteria to include adult patients? How many of
those have been diagnosed during infancy/childhood so that the guidelines cited are applicable?
Was the level of xerostomia associated to celiac disease age at diagnosis and possibly disease
duration?
Please also indicate how long patients of the study have been on a gluten-free diet since this
might impact on anti-tissue transglutaminase IgA in the saliva
p value should have a p not in capital
In discussion when citing that CD has a wide range of clinical manifestations please cite PMID:
31772571; PMID: 25162363  PMID: 34684612
Since the authors focused on xerostomia, please quickly mention in discussion also other
possible oral manifestation of CD; with this regard, please cite the paper by Amato M PMID:
29207559
Conclusion should be downsized since saliva evalutation has been performed during follow-up
and not at diagnosis.
Title: Serum and Salivary Tissue Transglutaminase IGA (tTG-IGA) Level in Celiac Patients
Version: 1 Date: 09 Jun 2022
Reviewer's report:
I suggest to use CD after the first time Celiac Disease has been quoted.
Why did the authors use pediatric diagnostic criteria to include adult patients? How many of
those have been diagnosed during infancy/childhood so that the guidelines cited are applicable?
Was the level of xerostomia associated to celiac disease age at diagnosis and possibly disease
duration?
Please also indicate how long patients of the study have been on a gluten-free diet since this
might impact on anti-tissue transglutaminase IgA in the saliva
p value should have a p not in capital
In discussion when citing that CD has a wide range of clinical manifestations please cite PMID:
31772571; PMID: 25162363  PMID: 34684612
Since the authors focused on xerostomia, please quickly mention in discussion also other
possible oral manifestation of CD; with this regard, please cite the paper by Amato M PMID:
29207559
Conclusion should be downsized since saliva evalutation has been performed during follow-up
and not at diagnosis.
Please review this paper.
user
Title: Serum and Salivary Tissue Transglutaminase IGA (tTG-IGA) Level in Celiac Patients
Version: 1 Date: 09 Jun 2022
Reviewer's report:
I suggest to use CD after the first time Celiac Disease has been quoted.
Why did the authors use pediatric diagnostic criteria to include adult patients? How many of
those have been diagnosed during infancy/childhood so that the guidelines cited are applicable?
Was the level of xerostomia associated to celiac disease age at diagnosis and possibly disease
duration?
Please also indicate how long patients of the study have been on a gluten-free diet since this
might impact on anti-tissue transglutaminase IgA in the saliva
p value should have a p not in capital
In discussion when citing that CD has a wide range of clinical manifestations please cite PMID:
31772571; PMID: 25162363  PMID: 34684612
Since the authors focused on xerostomia, please quickly mention in discussion also other
possible oral manifestation of CD; with this regard, please cite the paper by Amato M PMID:
29207559
Conclusion should be downsized since saliva evalutation has been performed during follow-up
and not at diagnosis.
assistant