Title: Management of hepatocellular carcinoma, an important cause of death in Japanese
autoimmune hepatitis patients
Version: 3 Date: 11 Feb 2024
Reviewer's report:
The authors investigated the characteristics of hepatocellular carcinoma (HCC) in autoimmune
hepatitis (AIH) patients. They found that HCC could occur as the duration of AIH. Cirrhosis at
the diagnosis of AIH was defined as a risk factor for carcinogenesis. Although the content of
this study is interesting, the following points need to be addressed:
Major
1. The main findings that cirrhosis as the risk for hepatocarcinogenesis is widely accepted. There
must be some additional new findings to define the result as new. Is there any difference between
old cases and recent cases?
2. Since the diagnosis of cirrhosis involves subjective factors, why don’t you consider what
would happen if you did a multivariate analysis using only objective factors?
Title: Management of hepatocellular carcinoma, an important cause of death in Japanese
autoimmune hepatitis patients
Version: 3 Date: 11 Feb 2024
Reviewer's report:
The authors investigated the characteristics of hepatocellular carcinoma (HCC) in autoimmune
hepatitis (AIH) patients. They found that HCC could occur as the duration of AIH. Cirrhosis at
the diagnosis of AIH was defined as a risk factor for carcinogenesis. Although the content of
this study is interesting, the following points need to be addressed:
Major
1. The main findings that cirrhosis as the risk for hepatocarcinogenesis is widely accepted. There
must be some additional new findings to define the result as new. Is there any difference between
old cases and recent cases?
2. Since the diagnosis of cirrhosis involves subjective factors, why don’t you consider what
would happen if you did a multivariate analysis using only objective factors?
Please review this paper.
user
Title: Management of hepatocellular carcinoma, an important cause of death in Japanese
autoimmune hepatitis patients
Version: 3 Date: 11 Feb 2024
Reviewer's report:
The authors investigated the characteristics of hepatocellular carcinoma (HCC) in autoimmune
hepatitis (AIH) patients. They found that HCC could occur as the duration of AIH. Cirrhosis at
the diagnosis of AIH was defined as a risk factor for carcinogenesis. Although the content of
this study is interesting, the following points need to be addressed:
Major
1. The main findings that cirrhosis as the risk for hepatocarcinogenesis is widely accepted. There
must be some additional new findings to define the result as new. Is there any difference between
old cases and recent cases?
2. Since the diagnosis of cirrhosis involves subjective factors, why don’t you consider what
would happen if you did a multivariate analysis using only objective factors?
assistant