Title: C-reactive protein is associated with postoperative outcomes in patients with intestinal
Behçet’s disease
Version: 1 Date: 15 Apr 2021
Reviewer's report:
Thank you for reviewing the manuscript titled “ Role of C-reactive protein in predicting
postoperative outcomes in patients with intestinal Behçet’s disease”
The present manuscript is well written regarding the importance of measuring serum CRP
level immediately after surgery to predict postoperative complication and clinical recurrences.
Because intestinal Behçet’s disease is relatively rare disease, therefore there few evidences about
usefulness of biomarkers including CRP in patients with intestinal Behçet’s disease. I have
several comments described as below.
1 The authors assessed CRP levels within 5 days after surgery. This reviewer is considering that
CRP levels are quite different among Day1, Day3 and Day5. The authors should discuss about
the differences of CRP levels depending on the days after surgery.
2 Also, CRP levels, albumin levels, the presence of large ulcer (volcano ulcer), fistula, or abscess
prior to surgery should be collected and then, relationship between postoperative complication
and disease severity/serum markers should be assessed.
3 As Table 4 and Figure 1 indicate, the diagnostic value does not seem to be so well. The authors
should discuss the benefit (easy?, non-invasive?, low cost?) and limitation of measuring CRP
just after surgery to assess the complication and prognosis.
Minor
1 For assessment of prognosis, median (mean) follow-up period should be presented.
2 Number of events including clinical relapse, re-operation, and re-admission should be
presented.
3 It should be clarified whether the presence of ulcer with volcano type before surgery was not
associated with postoperative surgy, described as above.
4 Please cite the reference regarding higher complication rate in BD than Crohn’s disease (page
4 L 78).
Title: C-reactive protein is associated with postoperative outcomes in patients with intestinal
Behçet’s disease
Version: 1 Date: 15 Apr 2021
Reviewer's report:
Thank you for reviewing the manuscript titled “ Role of C-reactive protein in predicting
postoperative outcomes in patients with intestinal Behçet’s disease”
The present manuscript is well written regarding the importance of measuring serum CRP
level immediately after surgery to predict postoperative complication and clinical recurrences.
Because intestinal Behçet’s disease is relatively rare disease, therefore there few evidences about
usefulness of biomarkers including CRP in patients with intestinal Behçet’s disease. I have
several comments described as below.
1 The authors assessed CRP levels within 5 days after surgery. This reviewer is considering that
CRP levels are quite different among Day1, Day3 and Day5. The authors should discuss about
the differences of CRP levels depending on the days after surgery.
2 Also, CRP levels, albumin levels, the presence of large ulcer (volcano ulcer), fistula, or abscess
prior to surgery should be collected and then, relationship between postoperative complication
and disease severity/serum markers should be assessed.
3 As Table 4 and Figure 1 indicate, the diagnostic value does not seem to be so well. The authors
should discuss the benefit (easy?, non-invasive?, low cost?) and limitation of measuring CRP
just after surgery to assess the complication and prognosis.
Minor
1 For assessment of prognosis, median (mean) follow-up period should be presented.
2 Number of events including clinical relapse, re-operation, and re-admission should be
presented.
3 It should be clarified whether the presence of ulcer with volcano type before surgery was not
associated with postoperative surgy, described as above.
4 Please cite the reference regarding higher complication rate in BD than Crohn’s disease (page
4 L 78).
Please review this paper.
user
Title: C-reactive protein is associated with postoperative outcomes in patients with intestinal
Behçet’s disease
Version: 1 Date: 15 Apr 2021
Reviewer's report:
Thank you for reviewing the manuscript titled “ Role of C-reactive protein in predicting
postoperative outcomes in patients with intestinal Behçet’s disease”
The present manuscript is well written regarding the importance of measuring serum CRP
level immediately after surgery to predict postoperative complication and clinical recurrences.
Because intestinal Behçet’s disease is relatively rare disease, therefore there few evidences about
usefulness of biomarkers including CRP in patients with intestinal Behçet’s disease. I have
several comments described as below.
1 The authors assessed CRP levels within 5 days after surgery. This reviewer is considering that
CRP levels are quite different among Day1, Day3 and Day5. The authors should discuss about
the differences of CRP levels depending on the days after surgery.
2 Also, CRP levels, albumin levels, the presence of large ulcer (volcano ulcer), fistula, or abscess
prior to surgery should be collected and then, relationship between postoperative complication
and disease severity/serum markers should be assessed.
3 As Table 4 and Figure 1 indicate, the diagnostic value does not seem to be so well. The authors
should discuss the benefit (easy?, non-invasive?, low cost?) and limitation of measuring CRP
just after surgery to assess the complication and prognosis.
Minor
1 For assessment of prognosis, median (mean) follow-up period should be presented.
2 Number of events including clinical relapse, re-operation, and re-admission should be
presented.
3 It should be clarified whether the presence of ulcer with volcano type before surgery was not
associated with postoperative surgy, described as above.
4 Please cite the reference regarding higher complication rate in BD than Crohn’s disease (page
4 L 78).
assistant