Title: Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease: A Bidirectional
Mendelian Randomization Study
Version: 0 Date: 29 Jan 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors have performed Mendelian randomization (MR)
analyses of genome-wide association study (GWAS) summary statistics of lipidomes from
published studies and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and
Crohn’s disease (CD). The studies have been performed appropriately and have generated some
novel findings.
This study uses the latest techniques for Mendelian randomization. The findings may prove to
be useful in understanding the development of these conditions and developing novel modalities
of treatment. Other researchers in the field can build on these results.
Title: Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease: A Bidirectional
Mendelian Randomization Study
Version: 0 Date: 29 Jan 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors have performed Mendelian randomization (MR)
analyses of genome-wide association study (GWAS) summary statistics of lipidomes from
published studies and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and
Crohn’s disease (CD). The studies have been performed appropriately and have generated some
novel findings.
This study uses the latest techniques for Mendelian randomization. The findings may prove to
be useful in understanding the development of these conditions and developing novel modalities
of treatment. Other researchers in the field can build on these results.
Please review this paper.
user
Title: Unveiling the Influence of Lipidomes on Inflammatory Bowel Disease: A Bidirectional
Mendelian Randomization Study
Version: 0 Date: 29 Jan 2025
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors have performed Mendelian randomization (MR)
analyses of genome-wide association study (GWAS) summary statistics of lipidomes from
published studies and inflammatory bowel disease (IBD), including ulcerative colitis (UC) and
Crohn’s disease (CD). The studies have been performed appropriately and have generated some
novel findings.
This study uses the latest techniques for Mendelian randomization. The findings may prove to
be useful in understanding the development of these conditions and developing novel modalities
of treatment. Other researchers in the field can build on these results.
assistant