Reviewer's report
Title:Comparison of clinical course and outcome of acute pancreatitis according
to the two main etiologies: alcohol and gallstone
Version:2Date:14 March 2015
Reviewer: Tsukasa Ikeura
Reviewer's report:
Major Compulsory Revisions
To compare the clinical course, outcomes, and mortality between alcoholic and
gallstone AP, it is important to determine the differences in the severity of AP on
admission between these two conditions. The authors reported that, there were
no significant differences in Ranson, BISAP, and APACHE-II scores within 48
hours after admission, whereas the prevalence of severe AP and the mortality
were significantly higher in the alcohol group than in the biliary group. I am sure
that these results indicated that there was no difference in the severity of AP on
admission between alcoholic and gallstone AP, but the patients with alcoholic AP
were more likely to become severe during the clinical course compared with
gallstone AP. Authors should discuss more about this point.
Minor Essential Revisions
None.
Discretionary Revisions
In patients with gallstone pancreatitis, the severity, clinical course and prognosis
could be associated with acute cholangitis and cholestasis. Recommend authors
discuss this issue.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Comparison of clinical course and outcome of acute pancreatitis according
to the two main etiologies: alcohol and gallstone
Version:2Date:14 March 2015
Reviewer: Tsukasa Ikeura
Reviewer's report:
Major Compulsory Revisions
To compare the clinical course, outcomes, and mortality between alcoholic and
gallstone AP, it is important to determine the differences in the severity of AP on
admission between these two conditions. The authors reported that, there were
no significant differences in Ranson, BISAP, and APACHE-II scores within 48
hours after admission, whereas the prevalence of severe AP and the mortality
were significantly higher in the alcohol group than in the biliary group. I am sure
that these results indicated that there was no difference in the severity of AP on
admission between alcoholic and gallstone AP, but the patients with alcoholic AP
were more likely to become severe during the clinical course compared with
gallstone AP. Authors should discuss more about this point.
Minor Essential Revisions
None.
Discretionary Revisions
In patients with gallstone pancreatitis, the severity, clinical course and prognosis
could be associated with acute cholangitis and cholestasis. Recommend authors
discuss this issue.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Comparison of clinical course and outcome of acute pancreatitis according
to the two main etiologies: alcohol and gallstone
Version:2Date:14 March 2015
Reviewer: Tsukasa Ikeura
Reviewer's report:
Major Compulsory Revisions
To compare the clinical course, outcomes, and mortality between alcoholic and
gallstone AP, it is important to determine the differences in the severity of AP on
admission between these two conditions. The authors reported that, there were
no significant differences in Ranson, BISAP, and APACHE-II scores within 48
hours after admission, whereas the prevalence of severe AP and the mortality
were significantly higher in the alcohol group than in the biliary group. I am sure
that these results indicated that there was no difference in the severity of AP on
admission between alcoholic and gallstone AP, but the patients with alcoholic AP
were more likely to become severe during the clinical course compared with
gallstone AP. Authors should discuss more about this point.
Minor Essential Revisions
None.
Discretionary Revisions
In patients with gallstone pancreatitis, the severity, clinical course and prognosis
could be associated with acute cholangitis and cholestasis. Recommend authors
discuss this issue.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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