Reviewer's report
Title:Potential blood-based markers of celiac disease
Version:1Date:24 May 2014
Reviewer: Maria Cristina Mazzilli
Reviewer's report:
In the present manuscript Hanna Bragde and colleagues identify three blood
markers potentially useful in the diagnostic of celiac disease. Protein level of
CXCL11 and mRNA levels of TNFRSF9 and TNFSF13B resulted significantly
increased in cases with CD compared with controls. All three potential CD
markers are involved in the regulation of the NF-#B complex.
A blood-based test that allows to skip the intestinal biopsy would be a valuable
advance in the diagnostic procedure of CD. The data given here, in a relatively
small number of patients, does not let any certainty on the diagnostic value of
these markers but it gives a starting point for further investigations.
The study is well designed, written and performed. The results are interesting
and important for the scientific community. It seems to be suitable for acceptance
in this journal.
Minor revisions:
1. Genes, but not proteins, must be in italics. Eg DQ2 (DQA1*05/DQB1*02,
without any spaces).
2. For the HLA risk gradient, in addition to ref 8, should be mentioned:
Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G, Lulli P,
Mazzilli MC: HLA-DQ and risk gradient for celiac disease. Hum Immunol. 2009;
70(1):55-9.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interests
Reviewer's report
Title:Potential blood-based markers of celiac disease
Version:1Date:24 May 2014
Reviewer: Maria Cristina Mazzilli
Reviewer's report:
In the present manuscript Hanna Bragde and colleagues identify three blood
markers potentially useful in the diagnostic of celiac disease. Protein level of
CXCL11 and mRNA levels of TNFRSF9 and TNFSF13B resulted significantly
increased in cases with CD compared with controls. All three potential CD
markers are involved in the regulation of the NF-#B complex.
A blood-based test that allows to skip the intestinal biopsy would be a valuable
advance in the diagnostic procedure of CD. The data given here, in a relatively
small number of patients, does not let any certainty on the diagnostic value of
these markers but it gives a starting point for further investigations.
The study is well designed, written and performed. The results are interesting
and important for the scientific community. It seems to be suitable for acceptance
in this journal.
Minor revisions:
1. Genes, but not proteins, must be in italics. Eg DQ2 (DQA1*05/DQB1*02,
without any spaces).
2. For the HLA risk gradient, in addition to ref 8, should be mentioned:
Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G, Lulli P,
Mazzilli MC: HLA-DQ and risk gradient for celiac disease. Hum Immunol. 2009;
70(1):55-9.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Potential blood-based markers of celiac disease
Version:1Date:24 May 2014
Reviewer: Maria Cristina Mazzilli
Reviewer's report:
In the present manuscript Hanna Bragde and colleagues identify three blood
markers potentially useful in the diagnostic of celiac disease. Protein level of
CXCL11 and mRNA levels of TNFRSF9 and TNFSF13B resulted significantly
increased in cases with CD compared with controls. All three potential CD
markers are involved in the regulation of the NF-#B complex.
A blood-based test that allows to skip the intestinal biopsy would be a valuable
advance in the diagnostic procedure of CD. The data given here, in a relatively
small number of patients, does not let any certainty on the diagnostic value of
these markers but it gives a starting point for further investigations.
The study is well designed, written and performed. The results are interesting
and important for the scientific community. It seems to be suitable for acceptance
in this journal.
Minor revisions:
1. Genes, but not proteins, must be in italics. Eg DQ2 (DQA1*05/DQB1*02,
without any spaces).
2. For the HLA risk gradient, in addition to ref 8, should be mentioned:
Megiorni F, Mora B, Bonamico M, Barbato M, Nenna R, Maiella G, Lulli P,
Mazzilli MC: HLA-DQ and risk gradient for celiac disease. Hum Immunol. 2009;
70(1):55-9.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I have no competing interests
assistant