Reviewe r’s report  
 
Title: Human gastric magnet -controlled capsule endoscopy co nducted in a standing position: 
The phase 1 study  
 
Version: 1 Date: 01 Jul 2019  
 
Reviewer: Zhuan Liao  
 
Reviewer's report:  
 
1. This is a newly developed magnet -controlled capsule endoscopy, which is consists of an 
ingestible capsule endoscope; a guidance magnet robot; a data recorder; and a computer 
workstation. However, there is no data on the resolution, the view angle or view depth of the 
capsule endoscopy. Besid es， there is no data on the magnetic field generated by the magnetic 
robot. If the patient is obese, is the magnetic field generated strong enough?  
 
 
2. The current magnetically controlled capsule endoscopy has sufficient ability to perform a 
complete examin ation of the gastric mucosa including gastric fundus and gastric cardia. Your 
description 'Current magnet -controlled capsule endoscopy (MCE) for the stomach is not yet 
satisfactory with respect to navigation control, especially in the gastric fundus and ca rdia' in the 
background may be inappropriate. Therefore, the important highlight of this newly developed 
MCE in the article, which is described as 'manipulation in the fundus and cardia regions was as 
easy as that in the antrum and body', seems not to be i nnovative enough.  
 
 
3. The time for the entire stomach examination took 27.8± 8.3 min (12 -45 min). The patient 
needs to stand for such a long time to receive the examination. Many patients with weak 
constitution can't tolerate standing for such a long time. Is the supine position more friendly to 
the patient?  
 
 
4. Since gastric preparation quality is one of the primary endpoints of this manuscript. Maybe 
you can add the images of the stomach in different degree of cleanliness and distention.  
 
 
5. In this manuscri pt, we did not see the images of the lesions detected by MCE. Have these 
diagnoses of polys and erosive lesions been confirmed by gastroscopy and histopathology ？ 
 
 
6. Could you provide the reference of the description of 'the angle becomes flattened to near 180° 
while the fundus' longitudinal axis comes to nearly overlap the longitudinal body axis'?  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please sp ecify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
  
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you  in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organi sation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursement s, fees, funding, or salary from an organization that 
holdsor has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this pa per? 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I unde rstand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report t o be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my name d report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewe r’s report  
 
Title: Human gastric magnet -controlled capsule endoscopy co nducted in a standing position: 
The phase 1 study  
 
Version: 1 Date: 01 Jul 2019  
 
Reviewer: Zhuan Liao  
 
Reviewer's report:  
 
1. This is a newly developed magnet -controlled capsule endoscopy, which is consists of an 
ingestible capsule endoscope; a guidance magnet robot; a data recorder; and a computer 
workstation. However, there is no data on the resolution, the view angle or view depth of the 
capsule endoscopy. Besid es， there is no data on the magnetic field generated by the magnetic 
robot. If the patient is obese, is the magnetic field generated strong enough?  
 
 
2. The current magnetically controlled capsule endoscopy has sufficient ability to perform a 
complete examin ation of the gastric mucosa including gastric fundus and gastric cardia. Your 
description 'Current magnet -controlled capsule endoscopy (MCE) for the stomach is not yet 
satisfactory with respect to navigation control, especially in the gastric fundus and ca rdia' in the 
background may be inappropriate. Therefore, the important highlight of this newly developed 
MCE in the article, which is described as 'manipulation in the fundus and cardia regions was as 
easy as that in the antrum and body', seems not to be i nnovative enough.  
 
 
3. The time for the entire stomach examination took 27.8± 8.3 min (12 -45 min). The patient 
needs to stand for such a long time to receive the examination. Many patients with weak 
constitution can't tolerate standing for such a long time. Is the supine position more friendly to 
the patient?  
 
 
4. Since gastric preparation quality is one of the primary endpoints of this manuscript. Maybe 
you can add the images of the stomach in different degree of cleanliness and distention.  
 
 
5. In this manuscri pt, we did not see the images of the lesions detected by MCE. Have these 
diagnoses of polys and erosive lesions been confirmed by gastroscopy and histopathology ？ 
 
 
6. Could you provide the reference of the description of 'the angle becomes flattened to near 180° 
while the fundus' longitudinal axis comes to nearly overlap the longitudinal body axis'?  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please sp ecify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
  
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you  in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organi sation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursement s, fees, funding, or salary from an organization that 
holdsor has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this pa per? 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I unde rstand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report t o be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my name d report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewe r’s report  
 
Title: Human gastric magnet -controlled capsule endoscopy co nducted in a standing position: 
The phase 1 study  
 
Version: 1 Date: 01 Jul 2019  
 
Reviewer: Zhuan Liao  
 
Reviewer's report:  
 
1. This is a newly developed magnet -controlled capsule endoscopy, which is consists of an 
ingestible capsule endoscope; a guidance magnet robot; a data recorder; and a computer 
workstation. However, there is no data on the resolution, the view angle or view depth of the 
capsule endoscopy. Besid es， there is no data on the magnetic field generated by the magnetic 
robot. If the patient is obese, is the magnetic field generated strong enough?  
 
 
2. The current magnetically controlled capsule endoscopy has sufficient ability to perform a 
complete examin ation of the gastric mucosa including gastric fundus and gastric cardia. Your 
description 'Current magnet -controlled capsule endoscopy (MCE) for the stomach is not yet 
satisfactory with respect to navigation control, especially in the gastric fundus and ca rdia' in the 
background may be inappropriate. Therefore, the important highlight of this newly developed 
MCE in the article, which is described as 'manipulation in the fundus and cardia regions was as 
easy as that in the antrum and body', seems not to be i nnovative enough.  
 
 
3. The time for the entire stomach examination took 27.8± 8.3 min (12 -45 min). The patient 
needs to stand for such a long time to receive the examination. Many patients with weak 
constitution can't tolerate standing for such a long time. Is the supine position more friendly to 
the patient?  
 
 
4. Since gastric preparation quality is one of the primary endpoints of this manuscript. Maybe 
you can add the images of the stomach in different degree of cleanliness and distention.  
 
 
5. In this manuscri pt, we did not see the images of the lesions detected by MCE. Have these 
diagnoses of polys and erosive lesions been confirmed by gastroscopy and histopathology ？ 
 
 
6. Could you provide the reference of the description of 'the angle becomes flattened to near 180° 
while the fundus' longitudinal axis comes to nearly overlap the longitudinal body axis'?  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please sp ecify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
  
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you  in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organi sation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursement s, fees, funding, or salary from an organization that 
holdsor has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this pa per? 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I unde rstand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report t o be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my name d report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant