Reviewer's report
Title:KRAS mutations: variable incidences in a Brazilian cohort of 8,234
metastatic colorectal cancer patients
Version:1Date:17 January 2014
Reviewer: Iris Nagtegaal
Reviewer's report:
The current paper reports on a large number of CRC cases in which the KRAS
mutation status has been determined. This wealth of data adds to the available
literature, however, there are a number of questions and comments:
- in the introduction there is a large paragraph on ER, and relation to CRC. This
is not relevant in the introduction, so a summarised part might be replaced to the
discussion. However, since the manuscript does not investigate ER status I think
this is speculative.
- figure 1 is incomplete
- although there is a significant difference between women and men in the
frequency of KRAS mutation, this difference is rather small.
- in the part about the age distribution the authors discuss all results as if these
are significant, however, this is not the case and I think that it is not realistic to
state that an opposite results is obtained in these cases.
- at least part of the data could be gathered in figures rather than tables, which
would make it easier to see the differences.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:KRAS mutations: variable incidences in a Brazilian cohort of 8,234
metastatic colorectal cancer patients
Version:1Date:17 January 2014
Reviewer: Iris Nagtegaal
Reviewer's report:
The current paper reports on a large number of CRC cases in which the KRAS
mutation status has been determined. This wealth of data adds to the available
literature, however, there are a number of questions and comments:
- in the introduction there is a large paragraph on ER, and relation to CRC. This
is not relevant in the introduction, so a summarised part might be replaced to the
discussion. However, since the manuscript does not investigate ER status I think
this is speculative.
- figure 1 is incomplete
- although there is a significant difference between women and men in the
frequency of KRAS mutation, this difference is rather small.
- in the part about the age distribution the authors discuss all results as if these
are significant, however, this is not the case and I think that it is not realistic to
state that an opposite results is obtained in these cases.
- at least part of the data could be gathered in figures rather than tables, which
would make it easier to see the differences.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:KRAS mutations: variable incidences in a Brazilian cohort of 8,234
metastatic colorectal cancer patients
Version:1Date:17 January 2014
Reviewer: Iris Nagtegaal
Reviewer's report:
The current paper reports on a large number of CRC cases in which the KRAS
mutation status has been determined. This wealth of data adds to the available
literature, however, there are a number of questions and comments:
- in the introduction there is a large paragraph on ER, and relation to CRC. This
is not relevant in the introduction, so a summarised part might be replaced to the
discussion. However, since the manuscript does not investigate ER status I think
this is speculative.
- figure 1 is incomplete
- although there is a significant difference between women and men in the
frequency of KRAS mutation, this difference is rather small.
- in the part about the age distribution the authors discuss all results as if these
are significant, however, this is not the case and I think that it is not realistic to
state that an opposite results is obtained in these cases.
- at least part of the data could be gathered in figures rather than tables, which
would make it easier to see the differences.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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