Reviewer's report
Title:Histone deacetylase (HDAC)-1, -2, -4 and -6 expression in human
pancreatic adenocarcinoma: associations with clinicopathological parameters,
tumor proliferative capacity and patients' survival
Version:2Date:29 August 2015
Reviewer: Tao Liu
Reviewer's report:
Giaginis C et al examined HDAC1, HDAC2, HDAC4 and HDAC6 protein
expression in pancreatic cancer tissues and counterpart normal cells, and
correlated HDAC expression with patient prognosis. Overall, this is an interesting
study.
Major comments:
HDAC1 and HDAC2 belong to class I HDAC. It would be more informative, if the
authors analyse the expression of HDAC1 and HDAC2 proteins together against
patient prognosis. It would also be informative, if the authors analyse the
expression of HDAC1, HDAC2, HDAC4 and HDAC6 proteins together against
patient prognosis.
The authors need to provide IHC data on HDAC1, HDAC2, HDAC4 and HDAC6
staining in normal pancreatic cells.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Histone deacetylase (HDAC)-1, -2, -4 and -6 expression in human
pancreatic adenocarcinoma: associations with clinicopathological parameters,
tumor proliferative capacity and patients' survival
Version:2Date:29 August 2015
Reviewer: Tao Liu
Reviewer's report:
Giaginis C et al examined HDAC1, HDAC2, HDAC4 and HDAC6 protein
expression in pancreatic cancer tissues and counterpart normal cells, and
correlated HDAC expression with patient prognosis. Overall, this is an interesting
study.
Major comments:
HDAC1 and HDAC2 belong to class I HDAC. It would be more informative, if the
authors analyse the expression of HDAC1 and HDAC2 proteins together against
patient prognosis. It would also be informative, if the authors analyse the
expression of HDAC1, HDAC2, HDAC4 and HDAC6 proteins together against
patient prognosis.
The authors need to provide IHC data on HDAC1, HDAC2, HDAC4 and HDAC6
staining in normal pancreatic cells.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Histone deacetylase (HDAC)-1, -2, -4 and -6 expression in human
pancreatic adenocarcinoma: associations with clinicopathological parameters,
tumor proliferative capacity and patients' survival
Version:2Date:29 August 2015
Reviewer: Tao Liu
Reviewer's report:
Giaginis C et al examined HDAC1, HDAC2, HDAC4 and HDAC6 protein
expression in pancreatic cancer tissues and counterpart normal cells, and
correlated HDAC expression with patient prognosis. Overall, this is an interesting
study.
Major comments:
HDAC1 and HDAC2 belong to class I HDAC. It would be more informative, if the
authors analyse the expression of HDAC1 and HDAC2 proteins together against
patient prognosis. It would also be informative, if the authors analyse the
expression of HDAC1, HDAC2, HDAC4 and HDAC6 proteins together against
patient prognosis.
The authors need to provide IHC data on HDAC1, HDAC2, HDAC4 and HDAC6
staining in normal pancreatic cells.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant