Title: Correlation analysis of MAFLD combined with central obesity and the incidence of
colorectal adenoma
Version: 1 Date: 19 Jul 2023
Reviewer's report:
Interesting paper, here are the comments of this reviewer  :
Title- make the title more "open", it is not appropriate to put the result of the study in the title .
Introduction- p 3 line 87 :  unclear sentence.
Patients and Methods - p 4 line 111 : this is a case.control study with incident cases and with
the measurement of exposure at the same time as the outcome measurement; p 4 line 115 : If
possible list the reasons for colonoscopy.
Results - P 7 line 194 : please describe the patients who did not enter the study ; p 8 table 1 :
please, indicate at the foot of the page the statistical tests used for the P values ;  p 10 table 3 :
the composition of the multivariable model is unclear ;  p 12 lines 264-5 : not clear ; p 13  tab
5:  multivariable model unclear  ; p 15 tab 6 : odds ratios are missing.
Discussion - The study has the problem that exposure and outcome measures are contemporary,
with uncertain direction of causality. p 16 line 314 : there are also flat adenomas ; p 20 line
419 : that is a problem of external validity ;  p 20 line 420 : absent knowledge of mechanisms
of associations are not a problem in epidemiology ;  p 20 line 422 : by introducing external
variables such as diet into models, biological variables become intermediate variables and create
problems in causal models.
Summary - p 20 lines 428-32  :  unclear sentence.
Title: Correlation analysis of MAFLD combined with central obesity and the incidence of
colorectal adenoma
Version: 1 Date: 19 Jul 2023
Reviewer's report:
Interesting paper, here are the comments of this reviewer  :
Title- make the title more "open", it is not appropriate to put the result of the study in the title .
Introduction- p 3 line 87 :  unclear sentence.
Patients and Methods - p 4 line 111 : this is a case.control study with incident cases and with
the measurement of exposure at the same time as the outcome measurement; p 4 line 115 : If
possible list the reasons for colonoscopy.
Results - P 7 line 194 : please describe the patients who did not enter the study ; p 8 table 1 :
please, indicate at the foot of the page the statistical tests used for the P values ;  p 10 table 3 :
the composition of the multivariable model is unclear ;  p 12 lines 264-5 : not clear ; p 13  tab
5:  multivariable model unclear  ; p 15 tab 6 : odds ratios are missing.
Discussion - The study has the problem that exposure and outcome measures are contemporary,
with uncertain direction of causality. p 16 line 314 : there are also flat adenomas ; p 20 line
419 : that is a problem of external validity ;  p 20 line 420 : absent knowledge of mechanisms
of associations are not a problem in epidemiology ;  p 20 line 422 : by introducing external
variables such as diet into models, biological variables become intermediate variables and create
problems in causal models.
Summary - p 20 lines 428-32  :  unclear sentence.
Please review this paper.
user
Title: Correlation analysis of MAFLD combined with central obesity and the incidence of
colorectal adenoma
Version: 1 Date: 19 Jul 2023
Reviewer's report:
Interesting paper, here are the comments of this reviewer  :
Title- make the title more "open", it is not appropriate to put the result of the study in the title .
Introduction- p 3 line 87 :  unclear sentence.
Patients and Methods - p 4 line 111 : this is a case.control study with incident cases and with
the measurement of exposure at the same time as the outcome measurement; p 4 line 115 : If
possible list the reasons for colonoscopy.
Results - P 7 line 194 : please describe the patients who did not enter the study ; p 8 table 1 :
please, indicate at the foot of the page the statistical tests used for the P values ;  p 10 table 3 :
the composition of the multivariable model is unclear ;  p 12 lines 264-5 : not clear ; p 13  tab
5:  multivariable model unclear  ; p 15 tab 6 : odds ratios are missing.
Discussion - The study has the problem that exposure and outcome measures are contemporary,
with uncertain direction of causality. p 16 line 314 : there are also flat adenomas ; p 20 line
419 : that is a problem of external validity ;  p 20 line 420 : absent knowledge of mechanisms
of associations are not a problem in epidemiology ;  p 20 line 422 : by introducing external
variables such as diet into models, biological variables become intermediate variables and create
problems in causal models.
Summary - p 20 lines 428-32  :  unclear sentence.
assistant