Reviewer ’s report  
 
Title: Serious postoperative complications induced by medical glue: three case reports  
   
Version: 3 Date: 29 Jul 2019  
 
Reviewer: Reviewer 2  
 
Reviewer's report:  
"REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER:  
 
Has the author addressed your concerns sufficiently for you to now recommend th e work as a 
technically sound contribution? Yes  
 
Reviewer comments: HAVE THE AUTHORS RESPONDED ADEQUATELY TO EACH OF 
THE QUESTIONS YOU RAISED IN YOUR COMMENTS?  
  Yes these authors have responded in a very courteous way and appropriately to my suggestions 
to markedly I prove the paper. I hope they understand that I was not criticizing THEM but rather 
their editing service.  I can only imagine trying to write a paper in Chinese characters!  
 
 
HAVE THEY MADE THE APPROPRIATE CHANGES IN THE MANUSCRIPT?  
  Yes in l arge part  
 
WHAT IS YOUR OVERALL IMPRESSION OF THE REVISED MANUSCRIPT?  
  I like the concept and would suggest the editor pursue this manuscript. Still it will need the help 
of an editing service that I assume the journal publisher's editors can do. I reite rate that I hope 
these authors reproached the original editing service and asked for their money back because that 
editing service did a TERRIBLE JOB!!!!!!  
  
 
REQUESTED REVISIONS:  
ARE THERE ANY ADDITIONAL REVISIONS THE AUTHORS SHOULD MAKE?  
 
1. Abstract: I w ould suggest that you add the phrase "'Various types of medical 
glues/adhesives/topical coagulants' which we will refer to as medical glues (MG)".   This would 
cover the multiple types being used currently!  
 
2. Abstract line 7: Change to "a the possible in appropriate use of the medical glue  B - butyl -2-
cyanoacrylate ". Reads better  
 
3. Abstract line 12: change to "intestinal obstruction related to a mass of residual non -absorbed 
MG  causing an internal hernia from  a dense adhesion"  
 
4. Page 3 line 2: Agai n I would say "In surgical practice, various forms of topical medical glues 
(MG) have widespread application as an adhesive or a topical anticoagulant"  
 
5 Page 3 line 10: Change "was effective" to "appeared to be effective in minimizing the 
occurrence of a delayed duodenal perforation"  
 
6. Page 3 line 13: Start a new paragraph here  
 
7. Page 3 line 17: Change "dissemination" to "distal embolization"  
 
8. Page 3 line 19: Add the words "can be" after the word "but"  
 
9 From now on I really cannot define every place that needs these subtle but important changes 
so I will concentrate of the bigger picture.  The journal editor and the publisher's editing service 
should deal with the type of edits I have suggested above.  
 
10. Page 4 line 7: Add the word "into" after "eroding"  
     Page 4 line 11: Change "roughening" to "irregularity"  
     Page 4 line 12: Delete the phrase "fat place" and only say "fat plane"  
     Page 4 line 17: Delete the word "pierced" this word is not appropriate, say "eroded"  
     Page 4 line 19: Delete the phrase "and embedded it in the neuromuscular layer".  I have no 
idea what you mean by this phrase nor the next sentence which can also be de leted because it 
makes no sense.  
 
11. Page 5 line 18: Delete the end of the sentence after the word "and".   Remember, of course 
you sent her home only after passing flatus and stool etc., no need to say that.  
 
12. Page 6 line 1: Put the word "close" in qu otes like I just did because this is NOT an accepted 
way to   "close" a mesenteric defect!  
 
13. Page 6 line 10: Replace the phrase "partial enterectomy" with "small bowel resection and 
primary enteroenterostomy"  
 
14. Page 6 line 16: Add the phrase "using a ppropriate indications" after the word "agent"  
 
15. Page 6 line 21: Add the phrase " in time, probably because of excessive quantities used"  
 
16. Page 7 lines 2 and 3: Change to "Because of what appears to be excessive application of"  
 
17. Page 7 line 8: Change to "The inappropriate and possibly excessive use of MG to "close" an 
operative mesenteric defect"  
 
18. Page 7 line 13: Delete "injure" and replace by "adhere to and erode into surrounding tissues 
and hollow organs like the gut"  
 
19. Page 12 line 2: Change "gastroscopic" to duodenoscopic" or "endoscopic""  
 
 
Are the methods appropriate and well des cribed?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions draw n adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript : 
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding , or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the  publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, writ e 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organization, Research Square. Reviewers with 
declared or apparent competing interests are no t utilized for t hese reviews. This reviewer has 
agreed to publication of their comments online under a Creat ive Commons Attribution License 
attributed to Research Square and was paid a small honorarium for  completing the review within 
a specified timeframe . Honoraria for reviews such as this are paid regardless of the reviewer 
recommendation.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as  confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Serious postoperative complications induced by medical glue: three case reports  
   
Version: 3 Date: 29 Jul 2019  
 
Reviewer: Reviewer 2  
 
Reviewer's report:  
"REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER:  
 
Has the author addressed your concerns sufficiently for you to now recommend th e work as a 
technically sound contribution? Yes  
 
Reviewer comments: HAVE THE AUTHORS RESPONDED ADEQUATELY TO EACH OF 
THE QUESTIONS YOU RAISED IN YOUR COMMENTS?  
  Yes these authors have responded in a very courteous way and appropriately to my suggestions 
to markedly I prove the paper. I hope they understand that I was not criticizing THEM but rather 
their editing service.  I can only imagine trying to write a paper in Chinese characters!  
 
 
HAVE THEY MADE THE APPROPRIATE CHANGES IN THE MANUSCRIPT?  
  Yes in l arge part  
 
WHAT IS YOUR OVERALL IMPRESSION OF THE REVISED MANUSCRIPT?  
  I like the concept and would suggest the editor pursue this manuscript. Still it will need the help 
of an editing service that I assume the journal publisher's editors can do. I reite rate that I hope 
these authors reproached the original editing service and asked for their money back because that 
editing service did a TERRIBLE JOB!!!!!!  
  
 
REQUESTED REVISIONS:  
ARE THERE ANY ADDITIONAL REVISIONS THE AUTHORS SHOULD MAKE?  
 
1. Abstract: I w ould suggest that you add the phrase "'Various types of medical 
glues/adhesives/topical coagulants' which we will refer to as medical glues (MG)".   This would 
cover the multiple types being used currently!  
 
2. Abstract line 7: Change to "a the possible in appropriate use of the medical glue  B - butyl -2-
cyanoacrylate ". Reads better  
 
3. Abstract line 12: change to "intestinal obstruction related to a mass of residual non -absorbed 
MG  causing an internal hernia from  a dense adhesion"  
 
4. Page 3 line 2: Agai n I would say "In surgical practice, various forms of topical medical glues 
(MG) have widespread application as an adhesive or a topical anticoagulant"  
 
5 Page 3 line 10: Change "was effective" to "appeared to be effective in minimizing the 
occurrence of a delayed duodenal perforation"  
 
6. Page 3 line 13: Start a new paragraph here  
 
7. Page 3 line 17: Change "dissemination" to "distal embolization"  
 
8. Page 3 line 19: Add the words "can be" after the word "but"  
 
9 From now on I really cannot define every place that needs these subtle but important changes 
so I will concentrate of the bigger picture.  The journal editor and the publisher's editing service 
should deal with the type of edits I have suggested above.  
 
10. Page 4 line 7: Add the word "into" after "eroding"  
     Page 4 line 11: Change "roughening" to "irregularity"  
     Page 4 line 12: Delete the phrase "fat place" and only say "fat plane"  
     Page 4 line 17: Delete the word "pierced" this word is not appropriate, say "eroded"  
     Page 4 line 19: Delete the phrase "and embedded it in the neuromuscular layer".  I have no 
idea what you mean by this phrase nor the next sentence which can also be de leted because it 
makes no sense.  
 
11. Page 5 line 18: Delete the end of the sentence after the word "and".   Remember, of course 
you sent her home only after passing flatus and stool etc., no need to say that.  
 
12. Page 6 line 1: Put the word "close" in qu otes like I just did because this is NOT an accepted 
way to   "close" a mesenteric defect!  
 
13. Page 6 line 10: Replace the phrase "partial enterectomy" with "small bowel resection and 
primary enteroenterostomy"  
 
14. Page 6 line 16: Add the phrase "using a ppropriate indications" after the word "agent"  
 
15. Page 6 line 21: Add the phrase " in time, probably because of excessive quantities used"  
 
16. Page 7 lines 2 and 3: Change to "Because of what appears to be excessive application of"  
 
17. Page 7 line 8: Change to "The inappropriate and possibly excessive use of MG to "close" an 
operative mesenteric defect"  
 
18. Page 7 line 13: Delete "injure" and replace by "adhere to and erode into surrounding tissues 
and hollow organs like the gut"  
 
19. Page 12 line 2: Change "gastroscopic" to duodenoscopic" or "endoscopic""  
 
 
Are the methods appropriate and well des cribed?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions draw n adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript : 
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding , or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the  publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, writ e 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organization, Research Square. Reviewers with 
declared or apparent competing interests are no t utilized for t hese reviews. This reviewer has 
agreed to publication of their comments online under a Creat ive Commons Attribution License 
attributed to Research Square and was paid a small honorarium for  completing the review within 
a specified timeframe . Honoraria for reviews such as this are paid regardless of the reviewer 
recommendation.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as  confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Serious postoperative complications induced by medical glue: three case reports  
   
Version: 3 Date: 29 Jul 2019  
 
Reviewer: Reviewer 2  
 
Reviewer's report:  
"REVISION ASSESSMENT FROM THE ACADEMIC PEER REVIEWER:  
 
Has the author addressed your concerns sufficiently for you to now recommend th e work as a 
technically sound contribution? Yes  
 
Reviewer comments: HAVE THE AUTHORS RESPONDED ADEQUATELY TO EACH OF 
THE QUESTIONS YOU RAISED IN YOUR COMMENTS?  
  Yes these authors have responded in a very courteous way and appropriately to my suggestions 
to markedly I prove the paper. I hope they understand that I was not criticizing THEM but rather 
their editing service.  I can only imagine trying to write a paper in Chinese characters!  
 
 
HAVE THEY MADE THE APPROPRIATE CHANGES IN THE MANUSCRIPT?  
  Yes in l arge part  
 
WHAT IS YOUR OVERALL IMPRESSION OF THE REVISED MANUSCRIPT?  
  I like the concept and would suggest the editor pursue this manuscript. Still it will need the help 
of an editing service that I assume the journal publisher's editors can do. I reite rate that I hope 
these authors reproached the original editing service and asked for their money back because that 
editing service did a TERRIBLE JOB!!!!!!  
  
 
REQUESTED REVISIONS:  
ARE THERE ANY ADDITIONAL REVISIONS THE AUTHORS SHOULD MAKE?  
 
1. Abstract: I w ould suggest that you add the phrase "'Various types of medical 
glues/adhesives/topical coagulants' which we will refer to as medical glues (MG)".   This would 
cover the multiple types being used currently!  
 
2. Abstract line 7: Change to "a the possible in appropriate use of the medical glue  B - butyl -2-
cyanoacrylate ". Reads better  
 
3. Abstract line 12: change to "intestinal obstruction related to a mass of residual non -absorbed 
MG  causing an internal hernia from  a dense adhesion"  
 
4. Page 3 line 2: Agai n I would say "In surgical practice, various forms of topical medical glues 
(MG) have widespread application as an adhesive or a topical anticoagulant"  
 
5 Page 3 line 10: Change "was effective" to "appeared to be effective in minimizing the 
occurrence of a delayed duodenal perforation"  
 
6. Page 3 line 13: Start a new paragraph here  
 
7. Page 3 line 17: Change "dissemination" to "distal embolization"  
 
8. Page 3 line 19: Add the words "can be" after the word "but"  
 
9 From now on I really cannot define every place that needs these subtle but important changes 
so I will concentrate of the bigger picture.  The journal editor and the publisher's editing service 
should deal with the type of edits I have suggested above.  
 
10. Page 4 line 7: Add the word "into" after "eroding"  
     Page 4 line 11: Change "roughening" to "irregularity"  
     Page 4 line 12: Delete the phrase "fat place" and only say "fat plane"  
     Page 4 line 17: Delete the word "pierced" this word is not appropriate, say "eroded"  
     Page 4 line 19: Delete the phrase "and embedded it in the neuromuscular layer".  I have no 
idea what you mean by this phrase nor the next sentence which can also be de leted because it 
makes no sense.  
 
11. Page 5 line 18: Delete the end of the sentence after the word "and".   Remember, of course 
you sent her home only after passing flatus and stool etc., no need to say that.  
 
12. Page 6 line 1: Put the word "close" in qu otes like I just did because this is NOT an accepted 
way to   "close" a mesenteric defect!  
 
13. Page 6 line 10: Replace the phrase "partial enterectomy" with "small bowel resection and 
primary enteroenterostomy"  
 
14. Page 6 line 16: Add the phrase "using a ppropriate indications" after the word "agent"  
 
15. Page 6 line 21: Add the phrase " in time, probably because of excessive quantities used"  
 
16. Page 7 lines 2 and 3: Change to "Because of what appears to be excessive application of"  
 
17. Page 7 line 8: Change to "The inappropriate and possibly excessive use of MG to "close" an 
operative mesenteric defect"  
 
18. Page 7 line 13: Delete "injure" and replace by "adhere to and erode into surrounding tissues 
and hollow organs like the gut"  
 
19. Page 12 line 2: Change "gastroscopic" to duodenoscopic" or "endoscopic""  
 
 
Are the methods appropriate and well des cribed?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions draw n adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript : 
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding , or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the  publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, writ e 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
This reviewer has been recruited by a partner organization, Research Square. Reviewers with 
declared or apparent competing interests are no t utilized for t hese reviews. This reviewer has 
agreed to publication of their comments online under a Creat ive Commons Attribution License 
attributed to Research Square and was paid a small honorarium for  completing the review within 
a specified timeframe . Honoraria for reviews such as this are paid regardless of the reviewer 
recommendation.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as  confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant