Title: Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer
over age 80: a retrospective study
Version: 2 Date: 23 Feb 2021
Reviewer:  Taishi Hata
Reviewer's report:
To the author
The authors concluded that carcinoembryonic antigen and prognostic nutritional index were
independent prognostic factors in super-elderly patients with mCRC. The reviewer thinks that
this paper is interested in colorectal surgeons and oncologists. Before the final decision, the
authors should revise several places so that the message of this paper more clearly This reviewer
believes that the process would make the manuscript more attractive.
Comments
Characteristics of the participants
Table1
The reviewer thinks that it is useful for the reader if there is a comparison of the metastatic sites
in the background.
Table1
Tumor located on the right side
Is this percentage calculated including rectal cancer? Also, what is the ratio in the two groups
of rectal cancer? The reviewer believes that the authors should clarify this point.
Chemotherapy
The reviewer was unable to find Table 3.
Survival
Are most of the deaths of super-elderly patients due to current illness? In particular, there were
only 12 patients who received chemotherapy, and if death from other diseases is included, the
data becomes unreliable.The authors should provide details on the cause of death of the super-
elderly patients included this study.
Title: Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer
over age 80: a retrospective study
Version: 2 Date: 23 Feb 2021
Reviewer:  Taishi Hata
Reviewer's report:
To the author
The authors concluded that carcinoembryonic antigen and prognostic nutritional index were
independent prognostic factors in super-elderly patients with mCRC. The reviewer thinks that
this paper is interested in colorectal surgeons and oncologists. Before the final decision, the
authors should revise several places so that the message of this paper more clearly This reviewer
believes that the process would make the manuscript more attractive.
Comments
Characteristics of the participants
Table1
The reviewer thinks that it is useful for the reader if there is a comparison of the metastatic sites
in the background.
Table1
Tumor located on the right side
Is this percentage calculated including rectal cancer? Also, what is the ratio in the two groups
of rectal cancer? The reviewer believes that the authors should clarify this point.
Chemotherapy
The reviewer was unable to find Table 3.
Survival
Are most of the deaths of super-elderly patients due to current illness? In particular, there were
only 12 patients who received chemotherapy, and if death from other diseases is included, the
data becomes unreliable.The authors should provide details on the cause of death of the super-
elderly patients included this study.
Please review this paper.
user
Title: Clinical and therapeutic features and prognostic factors of metastatic colorectal cancer
over age 80: a retrospective study
Version: 2 Date: 23 Feb 2021
Reviewer:  Taishi Hata
Reviewer's report:
To the author
The authors concluded that carcinoembryonic antigen and prognostic nutritional index were
independent prognostic factors in super-elderly patients with mCRC. The reviewer thinks that
this paper is interested in colorectal surgeons and oncologists. Before the final decision, the
authors should revise several places so that the message of this paper more clearly This reviewer
believes that the process would make the manuscript more attractive.
Comments
Characteristics of the participants
Table1
The reviewer thinks that it is useful for the reader if there is a comparison of the metastatic sites
in the background.
Table1
Tumor located on the right side
Is this percentage calculated including rectal cancer? Also, what is the ratio in the two groups
of rectal cancer? The reviewer believes that the authors should clarify this point.
Chemotherapy
The reviewer was unable to find Table 3.
Survival
Are most of the deaths of super-elderly patients due to current illness? In particular, there were
only 12 patients who received chemotherapy, and if death from other diseases is included, the
data becomes unreliable.The authors should provide details on the cause of death of the super-
elderly patients included this study.
assistant