Title: Local Resection Versus Radical Resection After Neoadjuvant Chemoradiotherapy for
Patients with Locally Advanced Rectal Cancer: A Propensity-score Matched Cohort Analysis
Version: 2 Date: 15 Feb 2023
Reviewer's report:
I would like to congratulate the authors on their work. They used a propensity-score matched
cohort analysis study to address the shortage of evidence regarding the safety of the local
resection
approach. Finally, they concluded that local resection can be a management option in selected
patients with middle-low rectal
cancer after nCRT for LARC. However, I do have some concerns that need to be addressed.
1."LR" appears for the first time in Introduction, so the full name of the word should be used.
2.Lymph node metastasis cannot be evaluated after local resection. How do we determine
ypTNM stage?
3.Through the K-M curve of DM, we can see that the result of LR is better than that of radical
resection. It is suggested that the author explain it in the discussion section.
4.The author mentioned in the discussion part that LN positivity rates was  21.4% for ypT2
tumors after receiving nCRT. ycT2 is included in the criteria for LR, In this case, the lymph
node metastasis rate is high, and the prognosis of patients will be relatively poor.
Title: Local Resection Versus Radical Resection After Neoadjuvant Chemoradiotherapy for
Patients with Locally Advanced Rectal Cancer: A Propensity-score Matched Cohort Analysis
Version: 2 Date: 15 Feb 2023
Reviewer's report:
I would like to congratulate the authors on their work. They used a propensity-score matched
cohort analysis study to address the shortage of evidence regarding the safety of the local
resection
approach. Finally, they concluded that local resection can be a management option in selected
patients with middle-low rectal
cancer after nCRT for LARC. However, I do have some concerns that need to be addressed.
1."LR" appears for the first time in Introduction, so the full name of the word should be used.
2.Lymph node metastasis cannot be evaluated after local resection. How do we determine
ypTNM stage?
3.Through the K-M curve of DM, we can see that the result of LR is better than that of radical
resection. It is suggested that the author explain it in the discussion section.
4.The author mentioned in the discussion part that LN positivity rates was  21.4% for ypT2
tumors after receiving nCRT. ycT2 is included in the criteria for LR, In this case, the lymph
node metastasis rate is high, and the prognosis of patients will be relatively poor.
Please review this paper.
user
Title: Local Resection Versus Radical Resection After Neoadjuvant Chemoradiotherapy for
Patients with Locally Advanced Rectal Cancer: A Propensity-score Matched Cohort Analysis
Version: 2 Date: 15 Feb 2023
Reviewer's report:
I would like to congratulate the authors on their work. They used a propensity-score matched
cohort analysis study to address the shortage of evidence regarding the safety of the local
resection
approach. Finally, they concluded that local resection can be a management option in selected
patients with middle-low rectal
cancer after nCRT for LARC. However, I do have some concerns that need to be addressed.
1."LR" appears for the first time in Introduction, so the full name of the word should be used.
2.Lymph node metastasis cannot be evaluated after local resection. How do we determine
ypTNM stage?
3.Through the K-M curve of DM, we can see that the result of LR is better than that of radical
resection. It is suggested that the author explain it in the discussion section.
4.The author mentioned in the discussion part that LN positivity rates was  21.4% for ypT2
tumors after receiving nCRT. ycT2 is included in the criteria for LR, In this case, the lymph
node metastasis rate is high, and the prognosis of patients will be relatively poor.
assistant