Reviewer's report
Title:Efficacy and tolerability of alpha galactosidase in treating gas-related
symptoms in children: a randomized, double-blind, placebo controlled trial.
Version: 4Date:29 April 2013
Reviewer: Anshu Srivastava
Reviewer's report:
Minor essential revisions:
• Abstract: Age needs to be added as shown in red. “Fifty-two pediatric patients
(32 female, age range 4-17) with chronic or recurrent gas-related symptoms were
randomized to receive placebo (n = 25) or #-galactosidase (n = 27)”.
• It is adequate to give the p value as 2 digits after decimal i.e 0.02 rather than
0.023
• Table 2, 3 and 4 can be put together as one table. And baseline symptom
section can be removed from table 1 as the same data will be shown in the
combined table of 2/3 and 4. Add the baseline data for number of days with
moderately to severe bloating also in the same table. So total FPS-R score, no of
days with severe bloating and individual symptoms baseline and end of treatment
will be shown in one table.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interest
Reviewer's report
Title:Efficacy and tolerability of alpha galactosidase in treating gas-related
symptoms in children: a randomized, double-blind, placebo controlled trial.
Version: 4Date:29 April 2013
Reviewer: Anshu Srivastava
Reviewer's report:
Minor essential revisions:
• Abstract: Age needs to be added as shown in red. “Fifty-two pediatric patients
(32 female, age range 4-17) with chronic or recurrent gas-related symptoms were
randomized to receive placebo (n = 25) or #-galactosidase (n = 27)”.
• It is adequate to give the p value as 2 digits after decimal i.e 0.02 rather than
0.023
• Table 2, 3 and 4 can be put together as one table. And baseline symptom
section can be removed from table 1 as the same data will be shown in the
combined table of 2/3 and 4. Add the baseline data for number of days with
moderately to severe bloating also in the same table. So total FPS-R score, no of
days with severe bloating and individual symptoms baseline and end of treatment
will be shown in one table.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interest
Please review this paper.
user
Reviewer's report
Title:Efficacy and tolerability of alpha galactosidase in treating gas-related
symptoms in children: a randomized, double-blind, placebo controlled trial.
Version: 4Date:29 April 2013
Reviewer: Anshu Srivastava
Reviewer's report:
Minor essential revisions:
• Abstract: Age needs to be added as shown in red. “Fifty-two pediatric patients
(32 female, age range 4-17) with chronic or recurrent gas-related symptoms were
randomized to receive placebo (n = 25) or #-galactosidase (n = 27)”.
• It is adequate to give the p value as 2 digits after decimal i.e 0.02 rather than
0.023
• Table 2, 3 and 4 can be put together as one table. And baseline symptom
section can be removed from table 1 as the same data will be shown in the
combined table of 2/3 and 4. Add the baseline data for number of days with
moderately to severe bloating also in the same table. So total FPS-R score, no of
days with severe bloating and individual symptoms baseline and end of treatment
will be shown in one table.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
no competing interest
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