Title: The molecular characteristics of gastric cancer patients living in Qinghai-Tibetan Plateau
Version: 4 Date: 04 Apr 2022
Reviewer:  EDOARDO VIRGILIO
Reviewer's report:
Please consider the following:
Introduction:
- "The incidence of gastric cancer in China ranks third in the world, and the mortality rate among
malignant tumors ranks first [7]. " It is not clear if you are talking about China or the rest of
the world. Please, rephrase.
- "Here, for better understanding the molecular mechanism of gastric cancer patients living in
and offer the targeted therapeutic strategies specially designed for patients living in QTP, we
collect ...": I do not understand when you say "offer". Please, rephrase.
- "We found that, these 31 patients are among 40 to 70 years old, most of them are male,
tumors are always located in antrum. By sequenced 31 paired tumor and normal bio-samples,
we found that, most of single nucleotide polymorphisms (SNP) are in chromosome 7 with C->T
and G->A as the most common alteration types, and the very different cancer driver genes from
western patients. The further analysis on driver genes indicates there is no significant differences
between minor ethnic groups and Han Chinese. Using an adapted kernel-based learning model
and a compilation of pharmacogenomics data of 462 patient-derived tumor cells (PDCs) that
illustrate the diverse genetic and molecular backgrounds of cancer patients [13], the specific
targeted therapeutics for these 31 sequenced patients are suggested." I would remove this part
from Introduction section.
- In general, please align the verb tenses in this section.
Methods:
- Tumor specimens and their paired normal bio-samples: Please, revise witing only  one sentence
about the compliance with ethical standards.
Results
- Clinical characteristics: Please, align the verb tenses.
Title: The molecular characteristics of gastric cancer patients living in Qinghai-Tibetan Plateau
Version: 4 Date: 04 Apr 2022
Reviewer:  EDOARDO VIRGILIO
Reviewer's report:
Please consider the following:
Introduction:
- "The incidence of gastric cancer in China ranks third in the world, and the mortality rate among
malignant tumors ranks first [7]. " It is not clear if you are talking about China or the rest of
the world. Please, rephrase.
- "Here, for better understanding the molecular mechanism of gastric cancer patients living in
and offer the targeted therapeutic strategies specially designed for patients living in QTP, we
collect ...": I do not understand when you say "offer". Please, rephrase.
- "We found that, these 31 patients are among 40 to 70 years old, most of them are male,
tumors are always located in antrum. By sequenced 31 paired tumor and normal bio-samples,
we found that, most of single nucleotide polymorphisms (SNP) are in chromosome 7 with C->T
and G->A as the most common alteration types, and the very different cancer driver genes from
western patients. The further analysis on driver genes indicates there is no significant differences
between minor ethnic groups and Han Chinese. Using an adapted kernel-based learning model
and a compilation of pharmacogenomics data of 462 patient-derived tumor cells (PDCs) that
illustrate the diverse genetic and molecular backgrounds of cancer patients [13], the specific
targeted therapeutics for these 31 sequenced patients are suggested." I would remove this part
from Introduction section.
- In general, please align the verb tenses in this section.
Methods:
- Tumor specimens and their paired normal bio-samples: Please, revise witing only  one sentence
about the compliance with ethical standards.
Results
- Clinical characteristics: Please, align the verb tenses.
Please review this paper.
user
Title: The molecular characteristics of gastric cancer patients living in Qinghai-Tibetan Plateau
Version: 4 Date: 04 Apr 2022
Reviewer:  EDOARDO VIRGILIO
Reviewer's report:
Please consider the following:
Introduction:
- "The incidence of gastric cancer in China ranks third in the world, and the mortality rate among
malignant tumors ranks first [7]. " It is not clear if you are talking about China or the rest of
the world. Please, rephrase.
- "Here, for better understanding the molecular mechanism of gastric cancer patients living in
and offer the targeted therapeutic strategies specially designed for patients living in QTP, we
collect ...": I do not understand when you say "offer". Please, rephrase.
- "We found that, these 31 patients are among 40 to 70 years old, most of them are male,
tumors are always located in antrum. By sequenced 31 paired tumor and normal bio-samples,
we found that, most of single nucleotide polymorphisms (SNP) are in chromosome 7 with C->T
and G->A as the most common alteration types, and the very different cancer driver genes from
western patients. The further analysis on driver genes indicates there is no significant differences
between minor ethnic groups and Han Chinese. Using an adapted kernel-based learning model
and a compilation of pharmacogenomics data of 462 patient-derived tumor cells (PDCs) that
illustrate the diverse genetic and molecular backgrounds of cancer patients [13], the specific
targeted therapeutics for these 31 sequenced patients are suggested." I would remove this part
from Introduction section.
- In general, please align the verb tenses in this section.
Methods:
- Tumor specimens and their paired normal bio-samples: Please, revise witing only  one sentence
about the compliance with ethical standards.
Results
- Clinical characteristics: Please, align the verb tenses.
assistant