Reviewer's report
Title:Montelukast in the treatment of duodenal eosinophilia in children with
dyspepsia: Effect on eosinophil density and activation in relation to
pharmacokinetics
Version: 1Date:5 February 2009
Reviewer: Frantisek Kopriva
Reviewer's report:
The author must complete demograhpic patient data, history of atopy - family and
patiens, family history of dyspepsia, kind of cuisine ?
The method of morphologic evaluation eosinohpilic granules is not very precise.
The pharmakokinetic study of montelukast is innapropriate for evaluation clinical
response in pateints with dyspepsia. Leukotrienens are effector meidators of
neurogenic inflammation. The author must complete discussion in relationship
between eosinophils and mast cells, regulation of neurogenic inflammattion.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have no interests
Reviewer's report
Title:Montelukast in the treatment of duodenal eosinophilia in children with
dyspepsia: Effect on eosinophil density and activation in relation to
pharmacokinetics
Version: 1Date:5 February 2009
Reviewer: Frantisek Kopriva
Reviewer's report:
The author must complete demograhpic patient data, history of atopy - family and
patiens, family history of dyspepsia, kind of cuisine ?
The method of morphologic evaluation eosinohpilic granules is not very precise.
The pharmakokinetic study of montelukast is innapropriate for evaluation clinical
response in pateints with dyspepsia. Leukotrienens are effector meidators of
neurogenic inflammation. The author must complete discussion in relationship
between eosinophils and mast cells, regulation of neurogenic inflammattion.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have no interests
Please review this paper.
user
Reviewer's report
Title:Montelukast in the treatment of duodenal eosinophilia in children with
dyspepsia: Effect on eosinophil density and activation in relation to
pharmacokinetics
Version: 1Date:5 February 2009
Reviewer: Frantisek Kopriva
Reviewer's report:
The author must complete demograhpic patient data, history of atopy - family and
patiens, family history of dyspepsia, kind of cuisine ?
The method of morphologic evaluation eosinohpilic granules is not very precise.
The pharmakokinetic study of montelukast is innapropriate for evaluation clinical
response in pateints with dyspepsia. Leukotrienens are effector meidators of
neurogenic inflammation. The author must complete discussion in relationship
between eosinophils and mast cells, regulation of neurogenic inflammattion.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I have no interests
assistant