Title: The Impact of Treatment with Bile Acid Sequestrants on Quality of Life in Patients with
Bile Acid Diarrhoea
Version: 2 Date: 15 Apr 2022
Reviewer:  Ginevra Berti
Reviewer's report:
I have examined again the article and I am grateful that the authors have accepted my suggestions
for the correction. The manuscript is now clearer. I would like just to clarify some points:
- I apologize for some mistakes that prevented the authors to understand two points of my
previous review, I have reported them with the correct number of page and lines (referring to
the updated manuscript)
o Page 14 line 365 for SF-36 MCS could you check if the values of P and N are correct?
o Page 14-15 lines 364-367 The phrase is a bit confused. It would be useful to separate
clinically and statistically significant findings. I also suggest correcting as “EQ-5D-3L pain and
discomfort”. Is not IBDQ32 also statistically significant? Talking about the moderate effect size
coefficient, should not it be >0.5?
- Page 23 Figure 1 legend line 525: The number of patients that completed the visit in figure 1
is 109, I think you should correct the legend
- About the comparison of the three groups’ scores (PC; BAD and CD) pre and post treatment
using the Student’s t-tests, check if it can be used to compare three groups or if it would be better
use another test like ANOVA
Title: The Impact of Treatment with Bile Acid Sequestrants on Quality of Life in Patients with
Bile Acid Diarrhoea
Version: 2 Date: 15 Apr 2022
Reviewer:  Ginevra Berti
Reviewer's report:
I have examined again the article and I am grateful that the authors have accepted my suggestions
for the correction. The manuscript is now clearer. I would like just to clarify some points:
- I apologize for some mistakes that prevented the authors to understand two points of my
previous review, I have reported them with the correct number of page and lines (referring to
the updated manuscript)
o Page 14 line 365 for SF-36 MCS could you check if the values of P and N are correct?
o Page 14-15 lines 364-367 The phrase is a bit confused. It would be useful to separate
clinically and statistically significant findings. I also suggest correcting as “EQ-5D-3L pain and
discomfort”. Is not IBDQ32 also statistically significant? Talking about the moderate effect size
coefficient, should not it be >0.5?
- Page 23 Figure 1 legend line 525: The number of patients that completed the visit in figure 1
is 109, I think you should correct the legend
- About the comparison of the three groups’ scores (PC; BAD and CD) pre and post treatment
using the Student’s t-tests, check if it can be used to compare three groups or if it would be better
use another test like ANOVA
Please review this paper.
user
Title: The Impact of Treatment with Bile Acid Sequestrants on Quality of Life in Patients with
Bile Acid Diarrhoea
Version: 2 Date: 15 Apr 2022
Reviewer:  Ginevra Berti
Reviewer's report:
I have examined again the article and I am grateful that the authors have accepted my suggestions
for the correction. The manuscript is now clearer. I would like just to clarify some points:
- I apologize for some mistakes that prevented the authors to understand two points of my
previous review, I have reported them with the correct number of page and lines (referring to
the updated manuscript)
o Page 14 line 365 for SF-36 MCS could you check if the values of P and N are correct?
o Page 14-15 lines 364-367 The phrase is a bit confused. It would be useful to separate
clinically and statistically significant findings. I also suggest correcting as “EQ-5D-3L pain and
discomfort”. Is not IBDQ32 also statistically significant? Talking about the moderate effect size
coefficient, should not it be >0.5?
- Page 23 Figure 1 legend line 525: The number of patients that completed the visit in figure 1
is 109, I think you should correct the legend
- About the comparison of the three groups’ scores (PC; BAD and CD) pre and post treatment
using the Student’s t-tests, check if it can be used to compare three groups or if it would be better
use another test like ANOVA
assistant