Title: RECENT ADVANCES IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS
Version: 3 Date: 27 Oct 2021
Reviewer's report:
This article is aim to review the latest diagnosis tools in clinic for the intestinal tuberculosis.
Although the article demonstrates the effectiveness of different diagnostic techniques, the paper
is too simple. The statistical and analytical data and discussion need further improve.
1-ABSTRACT
The results section simply lists the sensitivity and specificity of different detection methods,
which is not appropriate. It should show the range of sensitivity and specificity, since results
are  different in different reports.
The conclusion section “Recent modalities such as multiplex PCR and immunological marker
examinations have the highest sensitivity and specificity values and more evidence is expected
to support the application of this examination shortly soon”-highest specificity values is not
appropriate.
2-INTRODUCTION
“In 2017, 10 million cases of tuberculosis were reported worldwide with a mortality rate of
13%.”-should update the newest data.
3-RESULT
A.CLINICAL MANIFESTATIONS OF INTESTINAL TUBERCULOSIS
The results of this paper will be better compared with the results of imaging.
B.Immunological Markers
This manuscript lack the appropriate context to this part. For example, several articles have been
published this year defining some immunological markers to diagnosis of intestinal tuberculosis ,
such as CD73.
Scand J Gastroenterol. Oct-Nov 2018;53(10-11):1217-1221.
Dig Dis Sci. 2013 Aug;58(8):2301-7. doi: 10.1007/s10620-013-2667-0.
4-DISCUSSION
The discussion part is too simply, some questions need to discuss: What are the reason of defects
in different testing methods? What is the guiding effect for clinicians?What is the future of
diagnostic technology?
Title: RECENT ADVANCES IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS
Version: 3 Date: 27 Oct 2021
Reviewer's report:
This article is aim to review the latest diagnosis tools in clinic for the intestinal tuberculosis.
Although the article demonstrates the effectiveness of different diagnostic techniques, the paper
is too simple. The statistical and analytical data and discussion need further improve.
1-ABSTRACT
The results section simply lists the sensitivity and specificity of different detection methods,
which is not appropriate. It should show the range of sensitivity and specificity, since results
are  different in different reports.
The conclusion section “Recent modalities such as multiplex PCR and immunological marker
examinations have the highest sensitivity and specificity values and more evidence is expected
to support the application of this examination shortly soon”-highest specificity values is not
appropriate.
2-INTRODUCTION
“In 2017, 10 million cases of tuberculosis were reported worldwide with a mortality rate of
13%.”-should update the newest data.
3-RESULT
A.CLINICAL MANIFESTATIONS OF INTESTINAL TUBERCULOSIS
The results of this paper will be better compared with the results of imaging.
B.Immunological Markers
This manuscript lack the appropriate context to this part. For example, several articles have been
published this year defining some immunological markers to diagnosis of intestinal tuberculosis ,
such as CD73.
Scand J Gastroenterol. Oct-Nov 2018;53(10-11):1217-1221.
Dig Dis Sci. 2013 Aug;58(8):2301-7. doi: 10.1007/s10620-013-2667-0.
4-DISCUSSION
The discussion part is too simply, some questions need to discuss: What are the reason of defects
in different testing methods? What is the guiding effect for clinicians?What is the future of
diagnostic technology?
Please review this paper.
user
Title: RECENT ADVANCES IN THE DIAGNOSIS OF INTESTINAL TUBERCULOSIS
Version: 3 Date: 27 Oct 2021
Reviewer's report:
This article is aim to review the latest diagnosis tools in clinic for the intestinal tuberculosis.
Although the article demonstrates the effectiveness of different diagnostic techniques, the paper
is too simple. The statistical and analytical data and discussion need further improve.
1-ABSTRACT
The results section simply lists the sensitivity and specificity of different detection methods,
which is not appropriate. It should show the range of sensitivity and specificity, since results
are  different in different reports.
The conclusion section “Recent modalities such as multiplex PCR and immunological marker
examinations have the highest sensitivity and specificity values and more evidence is expected
to support the application of this examination shortly soon”-highest specificity values is not
appropriate.
2-INTRODUCTION
“In 2017, 10 million cases of tuberculosis were reported worldwide with a mortality rate of
13%.”-should update the newest data.
3-RESULT
A.CLINICAL MANIFESTATIONS OF INTESTINAL TUBERCULOSIS
The results of this paper will be better compared with the results of imaging.
B.Immunological Markers
This manuscript lack the appropriate context to this part. For example, several articles have been
published this year defining some immunological markers to diagnosis of intestinal tuberculosis ,
such as CD73.
Scand J Gastroenterol. Oct-Nov 2018;53(10-11):1217-1221.
Dig Dis Sci. 2013 Aug;58(8):2301-7. doi: 10.1007/s10620-013-2667-0.
4-DISCUSSION
The discussion part is too simply, some questions need to discuss: What are the reason of defects
in different testing methods? What is the guiding effect for clinicians?What is the future of
diagnostic technology?
assistant