Title: Prognostic Role of Preoperative Inflammatory Markers in Postoperative Lung Metastasis
of Colorectal Cancer: A Retrospective Study
Version: 1 Date: 25 Dec 2024
Reviewer's report:
There is a lack of detailed discussion on why lung metastasis was studied independently rather
than liver metastasis. It is recommended to elaborate on the unique prognostic or biological
mechanisms of lung metastasis, even though its prognosis may be better than that of liver
metastasis.
The rationale for selecting the inflammatory markers (e.g., NLR, PLR, CALLY) needs further
explanation. For instance, how do these markers address gaps in existing research?
Explain why patients with pre-existing inflammation or other malignancies were excluded from
the study.
Provide a biological or clinical explanation for the chosen cutoff values of the inflammatory
markers and clarify whether these cutoff values have been externally
How were missing data handled in the analysis?
Explain why logistic regression was used for baseline characteristic analysis, while Cox
regression was applied for outcome analysis, ensuring consistency in model selection and result
interpretation.
Further clarify why certain markers (e.g., SIRI, PLR) were significant in univariate analysis but
lost statistical significance in the multivariate model.
It is recommended to add more descriptive figure legends to the Kaplan-Meier curves to help
readers unfamiliar with specific markers quickly understand the results.
The discussion focuses heavily on positive findings (e.g., PNI and CALLY) but insufficiently
addresses negative results (e.g., LMR not being an independent predictor). It is suggested to
analyze the potential reasons for these findings.
Supplement the discussion with the biological mechanisms linking CALLY and PNI to
lung metastasis. For example, how do albumin and CRP levels influence the progression of
metastasis?
Title: Prognostic Role of Preoperative Inflammatory Markers in Postoperative Lung Metastasis
of Colorectal Cancer: A Retrospective Study
Version: 1 Date: 25 Dec 2024
Reviewer's report:
There is a lack of detailed discussion on why lung metastasis was studied independently rather
than liver metastasis. It is recommended to elaborate on the unique prognostic or biological
mechanisms of lung metastasis, even though its prognosis may be better than that of liver
metastasis.
The rationale for selecting the inflammatory markers (e.g., NLR, PLR, CALLY) needs further
explanation. For instance, how do these markers address gaps in existing research?
Explain why patients with pre-existing inflammation or other malignancies were excluded from
the study.
Provide a biological or clinical explanation for the chosen cutoff values of the inflammatory
markers and clarify whether these cutoff values have been externally
How were missing data handled in the analysis?
Explain why logistic regression was used for baseline characteristic analysis, while Cox
regression was applied for outcome analysis, ensuring consistency in model selection and result
interpretation.
Further clarify why certain markers (e.g., SIRI, PLR) were significant in univariate analysis but
lost statistical significance in the multivariate model.
It is recommended to add more descriptive figure legends to the Kaplan-Meier curves to help
readers unfamiliar with specific markers quickly understand the results.
The discussion focuses heavily on positive findings (e.g., PNI and CALLY) but insufficiently
addresses negative results (e.g., LMR not being an independent predictor). It is suggested to
analyze the potential reasons for these findings.
Supplement the discussion with the biological mechanisms linking CALLY and PNI to
lung metastasis. For example, how do albumin and CRP levels influence the progression of
metastasis?
Please review this paper.
user
Title: Prognostic Role of Preoperative Inflammatory Markers in Postoperative Lung Metastasis
of Colorectal Cancer: A Retrospective Study
Version: 1 Date: 25 Dec 2024
Reviewer's report:
There is a lack of detailed discussion on why lung metastasis was studied independently rather
than liver metastasis. It is recommended to elaborate on the unique prognostic or biological
mechanisms of lung metastasis, even though its prognosis may be better than that of liver
metastasis.
The rationale for selecting the inflammatory markers (e.g., NLR, PLR, CALLY) needs further
explanation. For instance, how do these markers address gaps in existing research?
Explain why patients with pre-existing inflammation or other malignancies were excluded from
the study.
Provide a biological or clinical explanation for the chosen cutoff values of the inflammatory
markers and clarify whether these cutoff values have been externally
How were missing data handled in the analysis?
Explain why logistic regression was used for baseline characteristic analysis, while Cox
regression was applied for outcome analysis, ensuring consistency in model selection and result
interpretation.
Further clarify why certain markers (e.g., SIRI, PLR) were significant in univariate analysis but
lost statistical significance in the multivariate model.
It is recommended to add more descriptive figure legends to the Kaplan-Meier curves to help
readers unfamiliar with specific markers quickly understand the results.
The discussion focuses heavily on positive findings (e.g., PNI and CALLY) but insufficiently
addresses negative results (e.g., LMR not being an independent predictor). It is suggested to
analyze the potential reasons for these findings.
Supplement the discussion with the biological mechanisms linking CALLY and PNI to
lung metastasis. For example, how do albumin and CRP levels influence the progression of
metastasis?
assistant