Reviewer's report 
 Effects of oral adenosine 5-'triphosphate and adenosine in enteric-coated capsules on Title: 
indomethacin-induced permeability changes in the human small intestine: a randomized cross-over study 
 1  26 March 2007 Version: Date: 
 Adrian Cummins Reviewer: 
Reviewer's report: 
General 
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This study is straight forward and it is unfortunate that a positive outcome was not obtained. The major 
issue is that I would like is more detail initially on the preceding study (reference 30) in the Introduction, as 
this information is scattered in various parts of the manuscript, but is critical to understanding this present study. Such issues are when the peak of permeability following indomethacin is expected and I wonder 
whether paragraph 4 in the Introduction could be deleted or moved to the Discussion. The study would be 
more interesting if the authors waited until further studies were completed (more frequent administration of 
ATP/adenosine) and hopefully these would yield a positive outcome. 
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None 
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None 
 Unable to decide on acceptance or rejection until the authors have responded to the major What next?: 
compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 No, the manuscript does not need to be seen by a statistician. Statistical review: 
Declaration of competing interests: 
I have no competing interests 
Reviewer's report 
 Effects of oral adenosine 5-'triphosphate and adenosine in enteric-coated capsules on Title: 
indomethacin-induced permeability changes in the human small intestine: a randomized cross-over study 
 1  26 March 2007 Version: Date: 
 Adrian Cummins Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
This study is straight forward and it is unfortunate that a positive outcome was not obtained. The major 
issue is that I would like is more detail initially on the preceding study (reference 30) in the Introduction, as 
this information is scattered in various parts of the manuscript, but is critical to understanding this present study. Such issues are when the peak of permeability following indomethacin is expected and I wonder 
whether paragraph 4 in the Introduction could be deleted or moved to the Discussion. The study would be 
more interesting if the authors waited until further studies were completed (more frequent administration of 
ATP/adenosine) and hopefully these would yield a positive outcome. 
------------------------------------------------------------------------------- 
None 
------------------------------------------------------------------------------- 
None 
 Unable to decide on acceptance or rejection until the authors have responded to the major What next?: 
compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 No, the manuscript does not need to be seen by a statistician. Statistical review: 
Declaration of competing interests: 
I have no competing interests 
Please review this paper.
user
Reviewer's report 
 Effects of oral adenosine 5-'triphosphate and adenosine in enteric-coated capsules on Title: 
indomethacin-induced permeability changes in the human small intestine: a randomized cross-over study 
 1  26 March 2007 Version: Date: 
 Adrian Cummins Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
This study is straight forward and it is unfortunate that a positive outcome was not obtained. The major 
issue is that I would like is more detail initially on the preceding study (reference 30) in the Introduction, as 
this information is scattered in various parts of the manuscript, but is critical to understanding this present study. Such issues are when the peak of permeability following indomethacin is expected and I wonder 
whether paragraph 4 in the Introduction could be deleted or moved to the Discussion. The study would be 
more interesting if the authors waited until further studies were completed (more frequent administration of 
ATP/adenosine) and hopefully these would yield a positive outcome. 
------------------------------------------------------------------------------- 
None 
------------------------------------------------------------------------------- 
None 
 Unable to decide on acceptance or rejection until the authors have responded to the major What next?: 
compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 No, the manuscript does not need to be seen by a statistician. Statistical review: 
Declaration of competing interests: 
I have no competing interests 
assistant