Title: Evaluation of the Rock1 and microRNA-148a expression in biopsies collected from
patients with Helicobacter pylori induced gastritis
Version: 1 Date: 18 Oct 2023
Reviewer:  Daniela Dobru
Reviewer's report:
The review of the manuscript leads to the following remarks :
- the article address an important pathological issue of the chronic H.Pylori infection - the genetic
expression of associated genes in positive H.Pylori patients as MicroRNA-148a is involved in
the regulation of various genes, including ROCK1, which is altered in gastric cancer. Decreased
expression of mir-148a leads to tumor metastasis and increased ROCK1 gene expression in
gastric cancer. However, according to some recent data , miRNA-148a is downregulated in
gastric cancers .
- the study design  and methodology is  accurate but small sample size of the present study is
an important limitation for the final results .
- in order to obtain more accurate results I would recommend to expand the study with more
patients and it would be interesting to study the gene expression in patients with premalignant
conditions for gastric cancer as atrophic gastritis.
Title: Evaluation of the Rock1 and microRNA-148a expression in biopsies collected from
patients with Helicobacter pylori induced gastritis
Version: 1 Date: 18 Oct 2023
Reviewer:  Daniela Dobru
Reviewer's report:
The review of the manuscript leads to the following remarks :
- the article address an important pathological issue of the chronic H.Pylori infection - the genetic
expression of associated genes in positive H.Pylori patients as MicroRNA-148a is involved in
the regulation of various genes, including ROCK1, which is altered in gastric cancer. Decreased
expression of mir-148a leads to tumor metastasis and increased ROCK1 gene expression in
gastric cancer. However, according to some recent data , miRNA-148a is downregulated in
gastric cancers .
- the study design  and methodology is  accurate but small sample size of the present study is
an important limitation for the final results .
- in order to obtain more accurate results I would recommend to expand the study with more
patients and it would be interesting to study the gene expression in patients with premalignant
conditions for gastric cancer as atrophic gastritis.
Please review this paper.
user
Title: Evaluation of the Rock1 and microRNA-148a expression in biopsies collected from
patients with Helicobacter pylori induced gastritis
Version: 1 Date: 18 Oct 2023
Reviewer:  Daniela Dobru
Reviewer's report:
The review of the manuscript leads to the following remarks :
- the article address an important pathological issue of the chronic H.Pylori infection - the genetic
expression of associated genes in positive H.Pylori patients as MicroRNA-148a is involved in
the regulation of various genes, including ROCK1, which is altered in gastric cancer. Decreased
expression of mir-148a leads to tumor metastasis and increased ROCK1 gene expression in
gastric cancer. However, according to some recent data , miRNA-148a is downregulated in
gastric cancers .
- the study design  and methodology is  accurate but small sample size of the present study is
an important limitation for the final results .
- in order to obtain more accurate results I would recommend to expand the study with more
patients and it would be interesting to study the gene expression in patients with premalignant
conditions for gastric cancer as atrophic gastritis.
assistant