Title: The frequency of colorectal lesions in the first-degree relatives of patients with colorectal
lesions among PERSIAN Guilan Cohort Study population (PGCS)
Version: 1 Date: 18 Dec 2023
Reviewer's report:
This manuscript, The frequency of colon lesions in the first-degree relatives of patients with
adenomatous polyp or premalignant/ malignant colon lesions referring to the PERSIAN Guilan
Elderly Cohort Study (PGECS), will be of interest, to both field experts and non-experts who
are merely interested in metabolic health. The manuscript is well written but could be improved.
I only have some minor comments for final improvements.
1. English editing is recommended by a professional language editing before it can be publish.
2. Please check carefully that all tables, and references are appropriately quoted in the core
manuscript.
3. In abstract section, according to the obtained results, please point out the reports of the
statistical analysis in the section of result.
4. The manuscript contains an elaborate literature review, but you should describe dietary habit
effect in colon polyps in the introduction.
5. Given the relationship between diabetes and greater risk of having colon polyps, it is
an important point to understand precisely the probable mechanisms. This aspect should be
highlighted in the discussion.
6. In the conclusion section, it will be beneficial, especially to non-experts if the authors can
give some dietary recommendations which may be required to protect against colon polyp.
Title: The frequency of colorectal lesions in the first-degree relatives of patients with colorectal
lesions among PERSIAN Guilan Cohort Study population (PGCS)
Version: 1 Date: 18 Dec 2023
Reviewer's report:
This manuscript, The frequency of colon lesions in the first-degree relatives of patients with
adenomatous polyp or premalignant/ malignant colon lesions referring to the PERSIAN Guilan
Elderly Cohort Study (PGECS), will be of interest, to both field experts and non-experts who
are merely interested in metabolic health. The manuscript is well written but could be improved.
I only have some minor comments for final improvements.
1. English editing is recommended by a professional language editing before it can be publish.
2. Please check carefully that all tables, and references are appropriately quoted in the core
manuscript.
3. In abstract section, according to the obtained results, please point out the reports of the
statistical analysis in the section of result.
4. The manuscript contains an elaborate literature review, but you should describe dietary habit
effect in colon polyps in the introduction.
5. Given the relationship between diabetes and greater risk of having colon polyps, it is
an important point to understand precisely the probable mechanisms. This aspect should be
highlighted in the discussion.
6. In the conclusion section, it will be beneficial, especially to non-experts if the authors can
give some dietary recommendations which may be required to protect against colon polyp.
Please review this paper.
user
Title: The frequency of colorectal lesions in the first-degree relatives of patients with colorectal
lesions among PERSIAN Guilan Cohort Study population (PGCS)
Version: 1 Date: 18 Dec 2023
Reviewer's report:
This manuscript, The frequency of colon lesions in the first-degree relatives of patients with
adenomatous polyp or premalignant/ malignant colon lesions referring to the PERSIAN Guilan
Elderly Cohort Study (PGECS), will be of interest, to both field experts and non-experts who
are merely interested in metabolic health. The manuscript is well written but could be improved.
I only have some minor comments for final improvements.
1. English editing is recommended by a professional language editing before it can be publish.
2. Please check carefully that all tables, and references are appropriately quoted in the core
manuscript.
3. In abstract section, according to the obtained results, please point out the reports of the
statistical analysis in the section of result.
4. The manuscript contains an elaborate literature review, but you should describe dietary habit
effect in colon polyps in the introduction.
5. Given the relationship between diabetes and greater risk of having colon polyps, it is
an important point to understand precisely the probable mechanisms. This aspect should be
highlighted in the discussion.
6. In the conclusion section, it will be beneficial, especially to non-experts if the authors can
give some dietary recommendations which may be required to protect against colon polyp.
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