Title: The Causal Impact of Genetically Predicted Inflammatory Bowel Disease on
Extraintestinal Manifestations: A Mendelian Randomization Study
Version: 4 Date: 04 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Aim should be rephrase using causal relationship and not impact Authors should
mention that they evaluated IBD as a whole and UC or CD as separate entities In methods
section the part that remained unchanged is difficult to follow If I am not not wrong authors
used GWAS data to identify common SNPs between IBD and EIMs aiming to identify causal
relationship between the two entities using Mendelian randomisation A short conclusion should
be introduced at the expence of background Methods Authors should define in which way they
have adapted GWAS data or made any selection in the population Otherwise the document is
much improved and after a final linguistic adjustment it would be ready for publication
Title: The Causal Impact of Genetically Predicted Inflammatory Bowel Disease on
Extraintestinal Manifestations: A Mendelian Randomization Study
Version: 4 Date: 04 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Aim should be rephrase using causal relationship and not impact Authors should
mention that they evaluated IBD as a whole and UC or CD as separate entities In methods
section the part that remained unchanged is difficult to follow If I am not not wrong authors
used GWAS data to identify common SNPs between IBD and EIMs aiming to identify causal
relationship between the two entities using Mendelian randomisation A short conclusion should
be introduced at the expence of background Methods Authors should define in which way they
have adapted GWAS data or made any selection in the population Otherwise the document is
much improved and after a final linguistic adjustment it would be ready for publication
Please review this paper.
user
Title: The Causal Impact of Genetically Predicted Inflammatory Bowel Disease on
Extraintestinal Manifestations: A Mendelian Randomization Study
Version: 4 Date: 04 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Aim should be rephrase using causal relationship and not impact Authors should
mention that they evaluated IBD as a whole and UC or CD as separate entities In methods
section the part that remained unchanged is difficult to follow If I am not not wrong authors
used GWAS data to identify common SNPs between IBD and EIMs aiming to identify causal
relationship between the two entities using Mendelian randomisation A short conclusion should
be introduced at the expence of background Methods Authors should define in which way they
have adapted GWAS data or made any selection in the population Otherwise the document is
much improved and after a final linguistic adjustment it would be ready for publication
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