Reviewer's report 
 Oxytocin and cholecystokinin secretion in women with colectomy. Title: 
 1  29 May 2004 Version: Date: 
 PAULUS S. WANG Reviewer: 
Reviewer's report: 
General 
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Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
1. The physiological role or significance of oxytocin in regulating GI function should be mentioned or 
discussed in the "Introduction" and/or "Discussion". 
2. The current evidence (Fig. 4) was not enough to support a decrease of metabolic clearance of 
CCK in colectomized women. The level of CCK in human plasma had to be saturated by infusion of CCK before measurement of metabolic clearance rate (MCR). 
3. Authors have to design an experiment (e.g. to use CCK receptor blockers) to confirm the source of 
oxytocin secretion (from brain or GI) following CCK challenge. 
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Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
The poor quality of figures should be improved. (e.g. use different symbols between control and 
patients or between basal and peak in both Fig. 1 and Fig. 3, and make clear scales over X-axis in 
both Fig. 2 and Fig. 4; n value should be exposed in each figure.) 
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Discretionary Revisions (which the author can choose to ignore) 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 Yes Statistical review: 
Declaration of competing interests: 
None 
Reviewer's report 
 Oxytocin and cholecystokinin secretion in women with colectomy. Title: 
 1  29 May 2004 Version: Date: 
 PAULUS S. WANG Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
1. The physiological role or significance of oxytocin in regulating GI function should be mentioned or 
discussed in the "Introduction" and/or "Discussion". 
2. The current evidence (Fig. 4) was not enough to support a decrease of metabolic clearance of 
CCK in colectomized women. The level of CCK in human plasma had to be saturated by infusion of CCK before measurement of metabolic clearance rate (MCR). 
3. Authors have to design an experiment (e.g. to use CCK receptor blockers) to confirm the source of 
oxytocin secretion (from brain or GI) following CCK challenge. 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
The poor quality of figures should be improved. (e.g. use different symbols between control and 
patients or between basal and peak in both Fig. 1 and Fig. 3, and make clear scales over X-axis in 
both Fig. 2 and Fig. 4; n value should be exposed in each figure.) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 Yes Statistical review: 
Declaration of competing interests: 
None 
Please review this paper.
user
Reviewer's report 
 Oxytocin and cholecystokinin secretion in women with colectomy. Title: 
 1  29 May 2004 Version: Date: 
 PAULUS S. WANG Reviewer: 
Reviewer's report: 
General 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
1. The physiological role or significance of oxytocin in regulating GI function should be mentioned or 
discussed in the "Introduction" and/or "Discussion". 
2. The current evidence (Fig. 4) was not enough to support a decrease of metabolic clearance of 
CCK in colectomized women. The level of CCK in human plasma had to be saturated by infusion of CCK before measurement of metabolic clearance rate (MCR). 
3. Authors have to design an experiment (e.g. to use CCK receptor blockers) to confirm the source of 
oxytocin secretion (from brain or GI) following CCK challenge. 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
The poor quality of figures should be improved. (e.g. use different symbols between control and 
patients or between basal and peak in both Fig. 1 and Fig. 3, and make clear scales over X-axis in 
both Fig. 2 and Fig. 4; n value should be exposed in each figure.) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
 Unable to decide on acceptance or rejection until the authors have responded to the What next?: 
major compulsory revisions 
 An article of limited interest Level of interest: 
 Acceptable Quality of written English: 
 Yes Statistical review: 
Declaration of competing interests: 
None 
assistant