Title: Evaluation of the association between periodontitis and inflammatory bowel disease: A
Systematic Review and Meta-analysis
Version: 0 Date: 27 Apr 2025
Reviewer:  Vito Annese
Reviewer's report:
I read with interest the systematic review and meta-analysis by Narges Naghsh et al with focus
on the association among periodontitis and IBD. 11 studies have been selected with 1322 IBD
patients and 1031 controls. The main finding  was an increased risk of periodontitis in IBD
(OR=2.3), with an higher risk in UC (OR=3.2) than in CD (OR=2.1). The Authors commented
also in the Discussion some of the possible (hypothetic) shared pathogenetic mechanisms such
as dysbiosisis and abnormal handling of pathogens.
The review is in general well-written and targeting an interesting aspect of the systemic
involvement of IBD.
I have only some minor suggestions:
In the conclusion of the abstract I would suggest that "more  longitudinal studies with larger
sample size are needed to  confirm such association and possibly disclose  the common
pathogenesis" rather than "mechanisms of IBD and treatment strategies".
The ORs of CD and UC are repetitively  reversed in the abstract and discussion. Please correct
11 studies are reported in the results section and table, but only 10 are mentioned in the discussion
In the discussion I would acknowledged the small sample size of the included studies as
limitation of the analysis: only 1 study with over 600 subjects (IBD and controls) and 6 studies
with less than 150!
It would be interesting for the readers to know whether such association was somewhat
correlated with disease activity in IBD or not; provided that such information is available in the
reviewed studies.
Title: Evaluation of the association between periodontitis and inflammatory bowel disease: A
Systematic Review and Meta-analysis
Version: 0 Date: 27 Apr 2025
Reviewer:  Vito Annese
Reviewer's report:
I read with interest the systematic review and meta-analysis by Narges Naghsh et al with focus
on the association among periodontitis and IBD. 11 studies have been selected with 1322 IBD
patients and 1031 controls. The main finding  was an increased risk of periodontitis in IBD
(OR=2.3), with an higher risk in UC (OR=3.2) than in CD (OR=2.1). The Authors commented
also in the Discussion some of the possible (hypothetic) shared pathogenetic mechanisms such
as dysbiosisis and abnormal handling of pathogens.
The review is in general well-written and targeting an interesting aspect of the systemic
involvement of IBD.
I have only some minor suggestions:
In the conclusion of the abstract I would suggest that "more  longitudinal studies with larger
sample size are needed to  confirm such association and possibly disclose  the common
pathogenesis" rather than "mechanisms of IBD and treatment strategies".
The ORs of CD and UC are repetitively  reversed in the abstract and discussion. Please correct
11 studies are reported in the results section and table, but only 10 are mentioned in the discussion
In the discussion I would acknowledged the small sample size of the included studies as
limitation of the analysis: only 1 study with over 600 subjects (IBD and controls) and 6 studies
with less than 150!
It would be interesting for the readers to know whether such association was somewhat
correlated with disease activity in IBD or not; provided that such information is available in the
reviewed studies.
Please review this paper.
user
Title: Evaluation of the association between periodontitis and inflammatory bowel disease: A
Systematic Review and Meta-analysis
Version: 0 Date: 27 Apr 2025
Reviewer:  Vito Annese
Reviewer's report:
I read with interest the systematic review and meta-analysis by Narges Naghsh et al with focus
on the association among periodontitis and IBD. 11 studies have been selected with 1322 IBD
patients and 1031 controls. The main finding  was an increased risk of periodontitis in IBD
(OR=2.3), with an higher risk in UC (OR=3.2) than in CD (OR=2.1). The Authors commented
also in the Discussion some of the possible (hypothetic) shared pathogenetic mechanisms such
as dysbiosisis and abnormal handling of pathogens.
The review is in general well-written and targeting an interesting aspect of the systemic
involvement of IBD.
I have only some minor suggestions:
In the conclusion of the abstract I would suggest that "more  longitudinal studies with larger
sample size are needed to  confirm such association and possibly disclose  the common
pathogenesis" rather than "mechanisms of IBD and treatment strategies".
The ORs of CD and UC are repetitively  reversed in the abstract and discussion. Please correct
11 studies are reported in the results section and table, but only 10 are mentioned in the discussion
In the discussion I would acknowledged the small sample size of the included studies as
limitation of the analysis: only 1 study with over 600 subjects (IBD and controls) and 6 studies
with less than 150!
It would be interesting for the readers to know whether such association was somewhat
correlated with disease activity in IBD or not; provided that such information is available in the
reviewed studies.
assistant