Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 4 Date: 11 Aug 2024
Reviewer's report:
The manuscript by Diallo and coworkers titled ‘KIF3C Promotes Human Colorectal Cancer Cell
Proliferation by Inhibiting Dependant Cell Cycle Progression’ describes the oncogenic potential
of KIF3C in colorectal cancer.
I ask the authors to address the following concerns.
1.        Please revisit the title. It does not make sense to write ‘….. by Inhibiting Dependant
Cell Cycle……’.
2.        Authors showed that manipulating KIF3c affects PI3K and AKT signaling. Authors claim
that KIF3C promotes migration and invasion by affecting the PI3K/AKT pathway. It is essential
to show that this pathway is sufficient to promote migration and invasion by rescue experiments
using overexpression or knockdown of PI3K/AKT or by using phosphomimetic mutants.
3.        Please show error bars in figure 3B.
Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 4 Date: 11 Aug 2024
Reviewer's report:
The manuscript by Diallo and coworkers titled ‘KIF3C Promotes Human Colorectal Cancer Cell
Proliferation by Inhibiting Dependant Cell Cycle Progression’ describes the oncogenic potential
of KIF3C in colorectal cancer.
I ask the authors to address the following concerns.
1.        Please revisit the title. It does not make sense to write ‘….. by Inhibiting Dependant
Cell Cycle……’.
2.        Authors showed that manipulating KIF3c affects PI3K and AKT signaling. Authors claim
that KIF3C promotes migration and invasion by affecting the PI3K/AKT pathway. It is essential
to show that this pathway is sufficient to promote migration and invasion by rescue experiments
using overexpression or knockdown of PI3K/AKT or by using phosphomimetic mutants.
3.        Please show error bars in figure 3B.
Please review this paper.
user
Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 4 Date: 11 Aug 2024
Reviewer's report:
The manuscript by Diallo and coworkers titled ‘KIF3C Promotes Human Colorectal Cancer Cell
Proliferation by Inhibiting Dependant Cell Cycle Progression’ describes the oncogenic potential
of KIF3C in colorectal cancer.
I ask the authors to address the following concerns.
1.        Please revisit the title. It does not make sense to write ‘….. by Inhibiting Dependant
Cell Cycle……’.
2.        Authors showed that manipulating KIF3c affects PI3K and AKT signaling. Authors claim
that KIF3C promotes migration and invasion by affecting the PI3K/AKT pathway. It is essential
to show that this pathway is sufficient to promote migration and invasion by rescue experiments
using overexpression or knockdown of PI3K/AKT or by using phosphomimetic mutants.
3.        Please show error bars in figure 3B.
assistant