Reviewer ’s report  
 
Title: Current role of colonoscopy in infants and young children: a multicenter study  
 
Version: 1 Date: 25 Jun 2019  
 
Reviewer: Looi Cheng Ee  
Reviewer's report:  
Study describes colonoscopy findings in young children aged <6yrs.  
 
Ileal intunbation rate was only described in  patients having general anaesthesia but not those 
with sedation. Was there a reason for this? Some explanation as to why that was so would be 
helpful.  
 
There are several grammatical changes that would improve how the paper reads including:  
 
In Background, the starting sentence should be "Advances in anesthetic techniques.......etc". The 
next sentence "........colon cancer in adults, there are few" not is few.  
 
In Discussion:  
"incompleting" is not a real word. Suggest sentence should read "Reasons for incom plete 
colonoscopy include severe colitis.........etc"  
 
The sentence "We defined EGID...........and malignancy" is already in Methods so no need to 
repeat it. Suggest delete this sentence from discussion.  
 
Also in discussion, the sentence "In the present st udy, it seems logical...........is therefore thought 
to be logical", the sentence would read better if the last part of the sentence "......is therefore 
thought to be logical" is omitted since you have already said it at the start. Suggest the sentence 
should read " In the present study, it seems logical that EGID and IBD were the most common 
diagnoses for children undergoing colonoscopy".   
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify whic h controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you r ecommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indi cate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares  in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you recei ved reimbursements, fees, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Current role of colonoscopy in infants and young children: a multicenter study  
 
Version: 1 Date: 25 Jun 2019  
 
Reviewer: Looi Cheng Ee  
Reviewer's report:  
Study describes colonoscopy findings in young children aged <6yrs.  
 
Ileal intunbation rate was only described in  patients having general anaesthesia but not those 
with sedation. Was there a reason for this? Some explanation as to why that was so would be 
helpful.  
 
There are several grammatical changes that would improve how the paper reads including:  
 
In Background, the starting sentence should be "Advances in anesthetic techniques.......etc". The 
next sentence "........colon cancer in adults, there are few" not is few.  
 
In Discussion:  
"incompleting" is not a real word. Suggest sentence should read "Reasons for incom plete 
colonoscopy include severe colitis.........etc"  
 
The sentence "We defined EGID...........and malignancy" is already in Methods so no need to 
repeat it. Suggest delete this sentence from discussion.  
 
Also in discussion, the sentence "In the present st udy, it seems logical...........is therefore thought 
to be logical", the sentence would read better if the last part of the sentence "......is therefore 
thought to be logical" is omitted since you have already said it at the start. Suggest the sentence 
should read " In the present study, it seems logical that EGID and IBD were the most common 
diagnoses for children undergoing colonoscopy".   
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify whic h controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you r ecommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indi cate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares  in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you recei ved reimbursements, fees, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Current role of colonoscopy in infants and young children: a multicenter study  
 
Version: 1 Date: 25 Jun 2019  
 
Reviewer: Looi Cheng Ee  
Reviewer's report:  
Study describes colonoscopy findings in young children aged <6yrs.  
 
Ileal intunbation rate was only described in  patients having general anaesthesia but not those 
with sedation. Was there a reason for this? Some explanation as to why that was so would be 
helpful.  
 
There are several grammatical changes that would improve how the paper reads including:  
 
In Background, the starting sentence should be "Advances in anesthetic techniques.......etc". The 
next sentence "........colon cancer in adults, there are few" not is few.  
 
In Discussion:  
"incompleting" is not a real word. Suggest sentence should read "Reasons for incom plete 
colonoscopy include severe colitis.........etc"  
 
The sentence "We defined EGID...........and malignancy" is already in Methods so no need to 
repeat it. Suggest delete this sentence from discussion.  
 
Also in discussion, the sentence "In the present st udy, it seems logical...........is therefore thought 
to be logical", the sentence would read better if the last part of the sentence "......is therefore 
thought to be logical" is omitted since you have already said it at the start. Suggest the sentence 
should read " In the present study, it seems logical that EGID and IBD were the most common 
diagnoses for children undergoing colonoscopy".   
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify whic h controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you r ecommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indi cate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares  in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you recei ved reimbursements, fees, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors ' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant