Reviewer's report
Title:A new family with hereditary lysozyme amyloidosis with gastritis and
inflammatory bowel disease as prevailing symptoms.
Version:4Date:10 July 2014
Reviewer: Jason Theis
Reviewer's report:
Major Compulsory Revisions: None
Minor Essential Revisions: None
Discretionary Revisions:
1) The authors state that Lysozyme immunohistochemistry was not performed on
all histological specimens. Given the wide array of amyloid subtypes and the
relative rarity of ALys I feel that is important to prove that each patients amyloid
deposits did consist of the lyzome protein. Did they consider requesting
unstained FFPE slides for lysozyme IHC?
2) Did the authors attempt any sort of computational modeling to assess the
potential of this mutation to alter the rate of fibril formation?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:A new family with hereditary lysozyme amyloidosis with gastritis and
inflammatory bowel disease as prevailing symptoms.
Version:4Date:10 July 2014
Reviewer: Jason Theis
Reviewer's report:
Major Compulsory Revisions: None
Minor Essential Revisions: None
Discretionary Revisions:
1) The authors state that Lysozyme immunohistochemistry was not performed on
all histological specimens. Given the wide array of amyloid subtypes and the
relative rarity of ALys I feel that is important to prove that each patients amyloid
deposits did consist of the lyzome protein. Did they consider requesting
unstained FFPE slides for lysozyme IHC?
2) Did the authors attempt any sort of computational modeling to assess the
potential of this mutation to alter the rate of fibril formation?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:A new family with hereditary lysozyme amyloidosis with gastritis and
inflammatory bowel disease as prevailing symptoms.
Version:4Date:10 July 2014
Reviewer: Jason Theis
Reviewer's report:
Major Compulsory Revisions: None
Minor Essential Revisions: None
Discretionary Revisions:
1) The authors state that Lysozyme immunohistochemistry was not performed on
all histological specimens. Given the wide array of amyloid subtypes and the
relative rarity of ALys I feel that is important to prove that each patients amyloid
deposits did consist of the lyzome protein. Did they consider requesting
unstained FFPE slides for lysozyme IHC?
2) Did the authors attempt any sort of computational modeling to assess the
potential of this mutation to alter the rate of fibril formation?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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