Reviewer's report
Title:Hydroxyurea and colonic ulcers: a case report
Version:2Date:15 June 2014
Reviewer: Lajos Kiss
Reviewer's report:
The clinical case of this case report is interesting. It shows a possible association
between hydroxyurea therapy and appear of colon ulceration. The article is
well-proportioned the idioms of article are meet the requirements. This report
have four main section: background, case presentation, discussion, conclusion.
My comments are the following:
- One month after initiation of hydroxyurea therapy in line with naporxen usage
massive hemathochezia begun and periodic epigastric pain with mucous
diarrhea persisted. The author advice was avoidance of naproxen, but really
discarding of this therapy are unofficially on the text.
- After first colonoscopy findings the area of ulcers are thriven based on the
second and third colonoscopy. These concerned parts of the bowel ancillary
superior mesenteric artery and vein system, but CT angiograhy was not made for
separation of thromboembolic disorders.
- According to authors after discontinuation of hydroxyurea therapy all GI
symptoms disappeared in 2 months. The text not contains what was the gastric
or bowel complain of the patient after surgery. The hydroxyurea induced stomach
erosions or ulcers well known, so it may regrediated after discontinuation of
hydroxyurea therapy. However, the association between colon symptoms and
therapy discontinuation is not affirmable.
- Histo-pathologic findings of oro-pharyngeal ulcers shows similarity with colon
ulcers, but oro-pharyngeal deviation appeared one month later when colon ulcers
was eliminated by surgery. In spite of similarity the common procession is not
verifiable.
- Discontiunation of hydroxyurea therapy was after colon surgery procedure, so it
may not known colon ulcers would have disapperaed or not.
In summary, in this case report published appear of colon ulceration after
initiation of hydroxyurea and naproxen therapy may assumable, but association
between discontinuation of hydroxyurea therapy and disappear of colon
ulceration are not verifiable. Because of strict correlation between medical
therapy and side effect is not speakable, the case report is not proposable for
acceptance.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Hydroxyurea and colonic ulcers: a case report
Version:2Date:15 June 2014
Reviewer: Lajos Kiss
Reviewer's report:
The clinical case of this case report is interesting. It shows a possible association
between hydroxyurea therapy and appear of colon ulceration. The article is
well-proportioned the idioms of article are meet the requirements. This report
have four main section: background, case presentation, discussion, conclusion.
My comments are the following:
- One month after initiation of hydroxyurea therapy in line with naporxen usage
massive hemathochezia begun and periodic epigastric pain with mucous
diarrhea persisted. The author advice was avoidance of naproxen, but really
discarding of this therapy are unofficially on the text.
- After first colonoscopy findings the area of ulcers are thriven based on the
second and third colonoscopy. These concerned parts of the bowel ancillary
superior mesenteric artery and vein system, but CT angiograhy was not made for
separation of thromboembolic disorders.
- According to authors after discontinuation of hydroxyurea therapy all GI
symptoms disappeared in 2 months. The text not contains what was the gastric
or bowel complain of the patient after surgery. The hydroxyurea induced stomach
erosions or ulcers well known, so it may regrediated after discontinuation of
hydroxyurea therapy. However, the association between colon symptoms and
therapy discontinuation is not affirmable.
- Histo-pathologic findings of oro-pharyngeal ulcers shows similarity with colon
ulcers, but oro-pharyngeal deviation appeared one month later when colon ulcers
was eliminated by surgery. In spite of similarity the common procession is not
verifiable.
- Discontiunation of hydroxyurea therapy was after colon surgery procedure, so it
may not known colon ulcers would have disapperaed or not.
In summary, in this case report published appear of colon ulceration after
initiation of hydroxyurea and naproxen therapy may assumable, but association
between discontinuation of hydroxyurea therapy and disappear of colon
ulceration are not verifiable. Because of strict correlation between medical
therapy and side effect is not speakable, the case report is not proposable for
acceptance.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Hydroxyurea and colonic ulcers: a case report
Version:2Date:15 June 2014
Reviewer: Lajos Kiss
Reviewer's report:
The clinical case of this case report is interesting. It shows a possible association
between hydroxyurea therapy and appear of colon ulceration. The article is
well-proportioned the idioms of article are meet the requirements. This report
have four main section: background, case presentation, discussion, conclusion.
My comments are the following:
- One month after initiation of hydroxyurea therapy in line with naporxen usage
massive hemathochezia begun and periodic epigastric pain with mucous
diarrhea persisted. The author advice was avoidance of naproxen, but really
discarding of this therapy are unofficially on the text.
- After first colonoscopy findings the area of ulcers are thriven based on the
second and third colonoscopy. These concerned parts of the bowel ancillary
superior mesenteric artery and vein system, but CT angiograhy was not made for
separation of thromboembolic disorders.
- According to authors after discontinuation of hydroxyurea therapy all GI
symptoms disappeared in 2 months. The text not contains what was the gastric
or bowel complain of the patient after surgery. The hydroxyurea induced stomach
erosions or ulcers well known, so it may regrediated after discontinuation of
hydroxyurea therapy. However, the association between colon symptoms and
therapy discontinuation is not affirmable.
- Histo-pathologic findings of oro-pharyngeal ulcers shows similarity with colon
ulcers, but oro-pharyngeal deviation appeared one month later when colon ulcers
was eliminated by surgery. In spite of similarity the common procession is not
verifiable.
- Discontiunation of hydroxyurea therapy was after colon surgery procedure, so it
may not known colon ulcers would have disapperaed or not.
In summary, in this case report published appear of colon ulceration after
initiation of hydroxyurea and naproxen therapy may assumable, but association
between discontinuation of hydroxyurea therapy and disappear of colon
ulceration are not verifiable. Because of strict correlation between medical
therapy and side effect is not speakable, the case report is not proposable for
acceptance.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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