Title: Eosinophilic Esophagitis Patients Report Substantial Disease Burden Comparable to
More Systemic Immune-Mediated Diseases
Version: 3 Date: 08 Apr 2025
Reviewer's report:
In this patient-initiated study, Theswet et al used a web-based questionnaire to assess quality
of life and disease-related impairment in Eosinophilic Esophagitis Patients compared to SSc,
SLE and IBD patients.
Among the 608 patients participated in the survey, EoE patients' perceived impairment in
everyday life appears to be comparable to that experienced by patients with other immune-
mediated disease states and worse among female EoE patients and those with a longer diagnostic
delay.
Overall, the manuscript is well written and the study well conducted.
Here are some comments:
1. The lack of formal validation of the questionnaire represents a major limitation for the
interpretation of data. A way to improve generazability would have been to use general QoL
questionnaires such as Sf-36 or the EuroQol.
2. Adding analysis of correlation between variables (general and within each group of patients)
would be helpful.
3. figures: Was a visual analogue scale (VAS) used or rather a numering rating scale (NRS)?
Please correct as appropriate.
Title: Eosinophilic Esophagitis Patients Report Substantial Disease Burden Comparable to
More Systemic Immune-Mediated Diseases
Version: 3 Date: 08 Apr 2025
Reviewer's report:
In this patient-initiated study, Theswet et al used a web-based questionnaire to assess quality
of life and disease-related impairment in Eosinophilic Esophagitis Patients compared to SSc,
SLE and IBD patients.
Among the 608 patients participated in the survey, EoE patients' perceived impairment in
everyday life appears to be comparable to that experienced by patients with other immune-
mediated disease states and worse among female EoE patients and those with a longer diagnostic
delay.
Overall, the manuscript is well written and the study well conducted.
Here are some comments:
1. The lack of formal validation of the questionnaire represents a major limitation for the
interpretation of data. A way to improve generazability would have been to use general QoL
questionnaires such as Sf-36 or the EuroQol.
2. Adding analysis of correlation between variables (general and within each group of patients)
would be helpful.
3. figures: Was a visual analogue scale (VAS) used or rather a numering rating scale (NRS)?
Please correct as appropriate.
Please review this paper.
user
Title: Eosinophilic Esophagitis Patients Report Substantial Disease Burden Comparable to
More Systemic Immune-Mediated Diseases
Version: 3 Date: 08 Apr 2025
Reviewer's report:
In this patient-initiated study, Theswet et al used a web-based questionnaire to assess quality
of life and disease-related impairment in Eosinophilic Esophagitis Patients compared to SSc,
SLE and IBD patients.
Among the 608 patients participated in the survey, EoE patients' perceived impairment in
everyday life appears to be comparable to that experienced by patients with other immune-
mediated disease states and worse among female EoE patients and those with a longer diagnostic
delay.
Overall, the manuscript is well written and the study well conducted.
Here are some comments:
1. The lack of formal validation of the questionnaire represents a major limitation for the
interpretation of data. A way to improve generazability would have been to use general QoL
questionnaires such as Sf-36 or the EuroQol.
2. Adding analysis of correlation between variables (general and within each group of patients)
would be helpful.
3. figures: Was a visual analogue scale (VAS) used or rather a numering rating scale (NRS)?
Please correct as appropriate.
assistant