Title: Effectiveness of betadine-coating gastrostomy tube to reduce peristomal infection after
percutaneous endoscopic gastrostomy: a randomized controlled trial
Version: 3 Date: 07 Jan 2023
Reviewer:  Anna Cominardi
Reviewer's report:
The work is about a relatively new topic and it's well-written.
Although betadine coating gastrostomy tube method doesn't reduce peristomal infection after
PEG, the study underlines the importance of 24-h delta CRP as predictor of peristomal wound
infection and all-cause infection within 14 days after PEG. We could easily use it in daily practice
since it is low-cost and routinely performed.
The study design is exhaustively described.
I have only some concerns:
- line 47: best cut-off point instead of points
- line 249-250: "Delta WBC, CRP, and hospitalization days were associated with higher all-
cause infection rates in univariable analysis..". I don't understand why you cite also delta WBC
since in the univariate analysis reported in table 3 the P value for delta WBC isn't statistically
significant (0.061).
SInce oral microbes represent most of the peristomal infection after PEG you can add some
suggestions in your text to overcome this (e.g. use of different antibiotics,...).
Title: Effectiveness of betadine-coating gastrostomy tube to reduce peristomal infection after
percutaneous endoscopic gastrostomy: a randomized controlled trial
Version: 3 Date: 07 Jan 2023
Reviewer:  Anna Cominardi
Reviewer's report:
The work is about a relatively new topic and it's well-written.
Although betadine coating gastrostomy tube method doesn't reduce peristomal infection after
PEG, the study underlines the importance of 24-h delta CRP as predictor of peristomal wound
infection and all-cause infection within 14 days after PEG. We could easily use it in daily practice
since it is low-cost and routinely performed.
The study design is exhaustively described.
I have only some concerns:
- line 47: best cut-off point instead of points
- line 249-250: "Delta WBC, CRP, and hospitalization days were associated with higher all-
cause infection rates in univariable analysis..". I don't understand why you cite also delta WBC
since in the univariate analysis reported in table 3 the P value for delta WBC isn't statistically
significant (0.061).
SInce oral microbes represent most of the peristomal infection after PEG you can add some
suggestions in your text to overcome this (e.g. use of different antibiotics,...).
Please review this paper.
user
Title: Effectiveness of betadine-coating gastrostomy tube to reduce peristomal infection after
percutaneous endoscopic gastrostomy: a randomized controlled trial
Version: 3 Date: 07 Jan 2023
Reviewer:  Anna Cominardi
Reviewer's report:
The work is about a relatively new topic and it's well-written.
Although betadine coating gastrostomy tube method doesn't reduce peristomal infection after
PEG, the study underlines the importance of 24-h delta CRP as predictor of peristomal wound
infection and all-cause infection within 14 days after PEG. We could easily use it in daily practice
since it is low-cost and routinely performed.
The study design is exhaustively described.
I have only some concerns:
- line 47: best cut-off point instead of points
- line 249-250: "Delta WBC, CRP, and hospitalization days were associated with higher all-
cause infection rates in univariable analysis..". I don't understand why you cite also delta WBC
since in the univariate analysis reported in table 3 the P value for delta WBC isn't statistically
significant (0.061).
SInce oral microbes represent most of the peristomal infection after PEG you can add some
suggestions in your text to overcome this (e.g. use of different antibiotics,...).
assistant