Reviewer ’s report  
 
Title: NEW MUTATION OF THE CERULOPLASMIN GENE IN THE CASE OF A 
NEUROLOGICALLY ASYMPTOMATIC PATIENT W ITH MICROCYTIC ANAEMIA, 
OBESITY AND SUPPOSED WILSON ’S DISEASE  
 
Version: 0 Date: 29 Dec 2019  
 
Reviewer: Uta Merle  
 
Reviewer's report:  
 
The authors descibe a case of a patient with aceruloplasminemia with a to date new homozygous 
mutation af the CP gene.  
 
The Patient i s stated to be asymptomatic before start of treatment and in 21 -month follow up 
control (under treatment with iron chelator).  
 
The magnitude of relevant new information is not high enough for consideration for publication 
in this journal.  
 
Besides, in any ca se I recommend to improve the manuscript with respect to written English. In 
addition giving more detailed information on the neurological and ophthalmological 
examinations performed to rule out symptoms, would also improve the report.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify whic h controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in th e manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
Quality of wri tten English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing i nterests' 
below. If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests.  
 
I agree to the open peer  review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the author s' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included  as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
 
Reviewer ’s report  
 
Title: NEW MUTATION OF THE CERULOPLASMIN GENE IN THE CASE OF A 
NEUROLOGICALLY ASYMPTOMATIC PATIENT W ITH MICROCYTIC ANAEMIA, 
OBESITY AND SUPPOSED WILSON ’S DISEASE  
 
Version: 0 Date: 29 Dec 2019  
 
Reviewer: Uta Merle  
 
Reviewer's report:  
 
The authors descibe a case of a patient with aceruloplasminemia with a to date new homozygous 
mutation af the CP gene.  
 
The Patient i s stated to be asymptomatic before start of treatment and in 21 -month follow up 
control (under treatment with iron chelator).  
 
The magnitude of relevant new information is not high enough for consideration for publication 
in this journal.  
 
Besides, in any ca se I recommend to improve the manuscript with respect to written English. In 
addition giving more detailed information on the neurological and ophthalmological 
examinations performed to rule out symptoms, would also improve the report.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify whic h controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in th e manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
Quality of wri tten English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing i nterests' 
below. If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests.  
 
I agree to the open peer  review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the author s' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included  as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
 
Please review this paper.
user
Reviewer ’s report  
 
Title: NEW MUTATION OF THE CERULOPLASMIN GENE IN THE CASE OF A 
NEUROLOGICALLY ASYMPTOMATIC PATIENT W ITH MICROCYTIC ANAEMIA, 
OBESITY AND SUPPOSED WILSON ’S DISEASE  
 
Version: 0 Date: 29 Dec 2019  
 
Reviewer: Uta Merle  
 
Reviewer's report:  
 
The authors descibe a case of a patient with aceruloplasminemia with a to date new homozygous 
mutation af the CP gene.  
 
The Patient i s stated to be asymptomatic before start of treatment and in 21 -month follow up 
control (under treatment with iron chelator).  
 
The magnitude of relevant new information is not high enough for consideration for publication 
in this journal.  
 
Besides, in any ca se I recommend to improve the manuscript with respect to written English. In 
addition giving more detailed information on the neurological and ophthalmological 
examinations performed to rule out symptoms, would also improve the report.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify whic h controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in th e manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
Quality of wri tten English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares  in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you recei ved reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing i nterests' 
below. If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests.  
 
I agree to the open peer  review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the author s' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included  as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
 
assistant