Reviewer's report
Title:Role of Vitamin K2 in Preventing the Recurrence of Hepatocellular
Carcinoma after Curative Treatment.A Meta-Analysis of Randomized Controlled
Trials.
Version: 1Date:3 July 2012
Reviewer: Masataka MS Seike
Reviewer's report:
In this article, the author summarized previous 5 RCTs that examined the effect
of vitamin K2 in preventing the recurrence of HCC using meta-analysis. The
author concluded that the efficacy of vitamin K2 in suppressing HCC recurrence
at 1 year was not confirmed in this meta-analysis.
Major compulsory revision
1.The largest and most recent trial by Yoshida and colleagues was performed as
a clinical trial (multicenter, placebo-controlled, double-blind trial enrolling 548
patients) to judge the preventive effect of vitamin K2 on HCC recurrence because
the previous results reported by Mizuta, Kakizaki and Hotta had been
inconsistent. So it is not appropriate to discuss these four manuscripts as same
category. In Japan, a consensus has been reached about no efficacy of vitamin
K2 in suppressing HCC recurrence after the clinical trial. Therefore we don’t think
this meta-analysis leads to a new knowledge in this field.
Minor essential revisions
1.Figure 1 is missing
2.In the Risults, 11th paragraph, 4th line, 95%CI:0.28-0.128 is a typographical
error, which should be read as 0.28-1.28.
3.Table 2, Mizuka is a typographical error for Mizuta.
4.Reference 1, the details of the journal are missing.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Role of Vitamin K2 in Preventing the Recurrence of Hepatocellular
Carcinoma after Curative Treatment.A Meta-Analysis of Randomized Controlled
Trials.
Version: 1Date:3 July 2012
Reviewer: Masataka MS Seike
Reviewer's report:
In this article, the author summarized previous 5 RCTs that examined the effect
of vitamin K2 in preventing the recurrence of HCC using meta-analysis. The
author concluded that the efficacy of vitamin K2 in suppressing HCC recurrence
at 1 year was not confirmed in this meta-analysis.
Major compulsory revision
1.The largest and most recent trial by Yoshida and colleagues was performed as
a clinical trial (multicenter, placebo-controlled, double-blind trial enrolling 548
patients) to judge the preventive effect of vitamin K2 on HCC recurrence because
the previous results reported by Mizuta, Kakizaki and Hotta had been
inconsistent. So it is not appropriate to discuss these four manuscripts as same
category. In Japan, a consensus has been reached about no efficacy of vitamin
K2 in suppressing HCC recurrence after the clinical trial. Therefore we don’t think
this meta-analysis leads to a new knowledge in this field.
Minor essential revisions
1.Figure 1 is missing
2.In the Risults, 11th paragraph, 4th line, 95%CI:0.28-0.128 is a typographical
error, which should be read as 0.28-1.28.
3.Table 2, Mizuka is a typographical error for Mizuta.
4.Reference 1, the details of the journal are missing.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Role of Vitamin K2 in Preventing the Recurrence of Hepatocellular
Carcinoma after Curative Treatment.A Meta-Analysis of Randomized Controlled
Trials.
Version: 1Date:3 July 2012
Reviewer: Masataka MS Seike
Reviewer's report:
In this article, the author summarized previous 5 RCTs that examined the effect
of vitamin K2 in preventing the recurrence of HCC using meta-analysis. The
author concluded that the efficacy of vitamin K2 in suppressing HCC recurrence
at 1 year was not confirmed in this meta-analysis.
Major compulsory revision
1.The largest and most recent trial by Yoshida and colleagues was performed as
a clinical trial (multicenter, placebo-controlled, double-blind trial enrolling 548
patients) to judge the preventive effect of vitamin K2 on HCC recurrence because
the previous results reported by Mizuta, Kakizaki and Hotta had been
inconsistent. So it is not appropriate to discuss these four manuscripts as same
category. In Japan, a consensus has been reached about no efficacy of vitamin
K2 in suppressing HCC recurrence after the clinical trial. Therefore we don’t think
this meta-analysis leads to a new knowledge in this field.
Minor essential revisions
1.Figure 1 is missing
2.In the Risults, 11th paragraph, 4th line, 95%CI:0.28-0.128 is a typographical
error, which should be read as 0.28-1.28.
3.Table 2, Mizuka is a typographical error for Mizuta.
4.Reference 1, the details of the journal are missing.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant