Title: The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis
and related mortality: Results from an umbrella meta-analysis on meta-analyses of randomized
controlled trials
Version: 0 Date: 12 Dec 2024
Reviewer's report:
Thank you for giving me the opportunity to review the manuscript entitled: The effectiveness of
treatment with probiotics in preventing necrotizing enterocolitis and related mortality: Results
from an umbrella meta-analysis on meta-analyses of randomized controlled trials. I find the work
very interesting and it provides new evidence on the usefulness of probiotics in Neonatal Units.
However, I see some inconsistencies in the methodological material section that I present below:
- I do not understand the selection criteria and it deviates from the objective of the study. I can
understand that the participants are newborns weighing less than 1500g, but not that they refer
to children with Helicobacter pylori eradication treatment.
- I also do not understand that the selection criteria are patients aged 18 years or older, a criterion
that should be directed to a population of premature newborns with very low birth weight.
The other aspects of the manuscript seem adequate to me.
Title: The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis
and related mortality: Results from an umbrella meta-analysis on meta-analyses of randomized
controlled trials
Version: 0 Date: 12 Dec 2024
Reviewer's report:
Thank you for giving me the opportunity to review the manuscript entitled: The effectiveness of
treatment with probiotics in preventing necrotizing enterocolitis and related mortality: Results
from an umbrella meta-analysis on meta-analyses of randomized controlled trials. I find the work
very interesting and it provides new evidence on the usefulness of probiotics in Neonatal Units.
However, I see some inconsistencies in the methodological material section that I present below:
- I do not understand the selection criteria and it deviates from the objective of the study. I can
understand that the participants are newborns weighing less than 1500g, but not that they refer
to children with Helicobacter pylori eradication treatment.
- I also do not understand that the selection criteria are patients aged 18 years or older, a criterion
that should be directed to a population of premature newborns with very low birth weight.
The other aspects of the manuscript seem adequate to me.
Please review this paper.
user
Title: The effectiveness of treatment with probiotics in preventing necrotizing enterocolitis
and related mortality: Results from an umbrella meta-analysis on meta-analyses of randomized
controlled trials
Version: 0 Date: 12 Dec 2024
Reviewer's report:
Thank you for giving me the opportunity to review the manuscript entitled: The effectiveness of
treatment with probiotics in preventing necrotizing enterocolitis and related mortality: Results
from an umbrella meta-analysis on meta-analyses of randomized controlled trials. I find the work
very interesting and it provides new evidence on the usefulness of probiotics in Neonatal Units.
However, I see some inconsistencies in the methodological material section that I present below:
- I do not understand the selection criteria and it deviates from the objective of the study. I can
understand that the participants are newborns weighing less than 1500g, but not that they refer
to children with Helicobacter pylori eradication treatment.
- I also do not understand that the selection criteria are patients aged 18 years or older, a criterion
that should be directed to a population of premature newborns with very low birth weight.
The other aspects of the manuscript seem adequate to me.
assistant