Title: NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot
tumor microenvironment in hepatocellular carcinoma
Version: 1 Date: 29 Jun 2022
Reviewer's report:
The potential biological functions of NAPSB were comprehensively explored in HCC,
including its differential expression,  prognosis value, and immunological role. We also
reported that high NAPSB expression was related to an immuno-hot TME and sensitive to
immunotherapy/chemotherapy, possibly affecting PANoptosis in HCC. The overall quality of
the article is good. The language is clear, and the logic is excellent. I think it is acceptable after
a minor revision.
1. A, B, C, and D in Figure 1 seem not aligned. Please make adjustments.
2. The font in Figure 5A is too dense. I hope the author can adjust it slightly.
3. The author conducted difference analysis and survival analysis in the Zhong nan cohort,
proving that the author had many samples. I hope the author can add WB or IHC experiments
or searched from the public database to check the expression of NAPSB protein in HCC.
Title: NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot
tumor microenvironment in hepatocellular carcinoma
Version: 1 Date: 29 Jun 2022
Reviewer's report:
The potential biological functions of NAPSB were comprehensively explored in HCC,
including its differential expression,  prognosis value, and immunological role. We also
reported that high NAPSB expression was related to an immuno-hot TME and sensitive to
immunotherapy/chemotherapy, possibly affecting PANoptosis in HCC. The overall quality of
the article is good. The language is clear, and the logic is excellent. I think it is acceptable after
a minor revision.
1. A, B, C, and D in Figure 1 seem not aligned. Please make adjustments.
2. The font in Figure 5A is too dense. I hope the author can adjust it slightly.
3. The author conducted difference analysis and survival analysis in the Zhong nan cohort,
proving that the author had many samples. I hope the author can add WB or IHC experiments
or searched from the public database to check the expression of NAPSB protein in HCC.
Please review this paper.
user
Title: NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot
tumor microenvironment in hepatocellular carcinoma
Version: 1 Date: 29 Jun 2022
Reviewer's report:
The potential biological functions of NAPSB were comprehensively explored in HCC,
including its differential expression,  prognosis value, and immunological role. We also
reported that high NAPSB expression was related to an immuno-hot TME and sensitive to
immunotherapy/chemotherapy, possibly affecting PANoptosis in HCC. The overall quality of
the article is good. The language is clear, and the logic is excellent. I think it is acceptable after
a minor revision.
1. A, B, C, and D in Figure 1 seem not aligned. Please make adjustments.
2. The font in Figure 5A is too dense. I hope the author can adjust it slightly.
3. The author conducted difference analysis and survival analysis in the Zhong nan cohort,
proving that the author had many samples. I hope the author can add WB or IHC experiments
or searched from the public database to check the expression of NAPSB protein in HCC.
assistant