Title: Serum pepsinogen levels in different regions of China and its influencing factors-a
multicenter cross-sectional study
Version: 1 Date: 17 Mar 2021
Reviewer's report:
The paper appears interesting making differences between regions of China as regards
pepsinogens levels and PGI/PGII ratio and for point out the rate of atrophic gastritis and more
severe OLGA staging has screening test in healthy population.
Nevertheless, I’m quite confuse about some points, in particular the relationship between
pepsinogens differences in various areas and possible involved factors. For instance, Pepsinogen
II is claimed worldwide as marker of inflammation of gastric mucosa, been related with H.p.
infection, but in the study the more elevated values of PGII are find in northeast and central north,
while the higher rate of H.p. infection where in southern and eastern. As regards the supposed
relationship between increase in PGI levels and presence of minority ethnic groups, the authors
mean genetics or environmental factors, like dietary, smoking habit, etc…
Some questions:
1 What about levels of PGI and ratio in subjects affected by atrophic gastritis (17.3%)?
2 What about the PGI values in patients with pictures of OLGA III/IV (2.5%)?
Title: Serum pepsinogen levels in different regions of China and its influencing factors-a
multicenter cross-sectional study
Version: 1 Date: 17 Mar 2021
Reviewer's report:
The paper appears interesting making differences between regions of China as regards
pepsinogens levels and PGI/PGII ratio and for point out the rate of atrophic gastritis and more
severe OLGA staging has screening test in healthy population.
Nevertheless, I’m quite confuse about some points, in particular the relationship between
pepsinogens differences in various areas and possible involved factors. For instance, Pepsinogen
II is claimed worldwide as marker of inflammation of gastric mucosa, been related with H.p.
infection, but in the study the more elevated values of PGII are find in northeast and central north,
while the higher rate of H.p. infection where in southern and eastern. As regards the supposed
relationship between increase in PGI levels and presence of minority ethnic groups, the authors
mean genetics or environmental factors, like dietary, smoking habit, etc…
Some questions:
1 What about levels of PGI and ratio in subjects affected by atrophic gastritis (17.3%)?
2 What about the PGI values in patients with pictures of OLGA III/IV (2.5%)?
Please review this paper.
user
Title: Serum pepsinogen levels in different regions of China and its influencing factors-a
multicenter cross-sectional study
Version: 1 Date: 17 Mar 2021
Reviewer's report:
The paper appears interesting making differences between regions of China as regards
pepsinogens levels and PGI/PGII ratio and for point out the rate of atrophic gastritis and more
severe OLGA staging has screening test in healthy population.
Nevertheless, I’m quite confuse about some points, in particular the relationship between
pepsinogens differences in various areas and possible involved factors. For instance, Pepsinogen
II is claimed worldwide as marker of inflammation of gastric mucosa, been related with H.p.
infection, but in the study the more elevated values of PGII are find in northeast and central north,
while the higher rate of H.p. infection where in southern and eastern. As regards the supposed
relationship between increase in PGI levels and presence of minority ethnic groups, the authors
mean genetics or environmental factors, like dietary, smoking habit, etc…
Some questions:
1 What about levels of PGI and ratio in subjects affected by atrophic gastritis (17.3%)?
2 What about the PGI values in patients with pictures of OLGA III/IV (2.5%)?
assistant