Title: A novel inflammatory marker for extensive ulcerative colitis; Endocan
Version: 3 Date: 01 Feb 2023
Reviewer:  Ilhami Yüksel
Reviewer's report:
In this study, the authors aimed to evaluate the usability of endocan level in determining the
extent and severity in patients with ulcerative colitis and to determine whether it can be a
candidate noninvasive marker for evaluation and monitoring in UC patients.
In the presented study, the authors found that there was a significant difference between all
ulcerative colitis patients and the control group in both endocan and CRP levels, and also there
was a significant correlation between endocan and CRP in the patient group.
This study will provide valuable information in our knowledge.  However, I do have some
suggestions.
I would like to suggest a title “A novel inflammatory marker for severe and extensive ulcerative
colitis; Endocan” instead of the current title “A novel inflammatory indicator in extensive
ulcerative colitis; Endocan?”
There are certain grammatical mistakes, including “…in the control group. patients with
newly…, Background and study aim: .., D#SCUSS#ON …”. Please correct all grammar
mistakes. Please switch to English-language tools; the paper was originally written in Turkish.
The last statement in the abstract and conclusion section,  “Stool markers may not always be
available due to patient compliance” should be removed.
Because this research will reveal whether there is a relationship between UC severity and
endocan levels, the authors should be evaluated to determine whether there is any correlation
between endocan and MES in patients with UC .
Title: A novel inflammatory marker for extensive ulcerative colitis; Endocan
Version: 3 Date: 01 Feb 2023
Reviewer:  Ilhami Yüksel
Reviewer's report:
In this study, the authors aimed to evaluate the usability of endocan level in determining the
extent and severity in patients with ulcerative colitis and to determine whether it can be a
candidate noninvasive marker for evaluation and monitoring in UC patients.
In the presented study, the authors found that there was a significant difference between all
ulcerative colitis patients and the control group in both endocan and CRP levels, and also there
was a significant correlation between endocan and CRP in the patient group.
This study will provide valuable information in our knowledge.  However, I do have some
suggestions.
I would like to suggest a title “A novel inflammatory marker for severe and extensive ulcerative
colitis; Endocan” instead of the current title “A novel inflammatory indicator in extensive
ulcerative colitis; Endocan?”
There are certain grammatical mistakes, including “…in the control group. patients with
newly…, Background and study aim: .., D#SCUSS#ON …”. Please correct all grammar
mistakes. Please switch to English-language tools; the paper was originally written in Turkish.
The last statement in the abstract and conclusion section,  “Stool markers may not always be
available due to patient compliance” should be removed.
Because this research will reveal whether there is a relationship between UC severity and
endocan levels, the authors should be evaluated to determine whether there is any correlation
between endocan and MES in patients with UC .
Please review this paper.
user
Title: A novel inflammatory marker for extensive ulcerative colitis; Endocan
Version: 3 Date: 01 Feb 2023
Reviewer:  Ilhami Yüksel
Reviewer's report:
In this study, the authors aimed to evaluate the usability of endocan level in determining the
extent and severity in patients with ulcerative colitis and to determine whether it can be a
candidate noninvasive marker for evaluation and monitoring in UC patients.
In the presented study, the authors found that there was a significant difference between all
ulcerative colitis patients and the control group in both endocan and CRP levels, and also there
was a significant correlation between endocan and CRP in the patient group.
This study will provide valuable information in our knowledge.  However, I do have some
suggestions.
I would like to suggest a title “A novel inflammatory marker for severe and extensive ulcerative
colitis; Endocan” instead of the current title “A novel inflammatory indicator in extensive
ulcerative colitis; Endocan?”
There are certain grammatical mistakes, including “…in the control group. patients with
newly…, Background and study aim: .., D#SCUSS#ON …”. Please correct all grammar
mistakes. Please switch to English-language tools; the paper was originally written in Turkish.
The last statement in the abstract and conclusion section,  “Stool markers may not always be
available due to patient compliance” should be removed.
Because this research will reveal whether there is a relationship between UC severity and
endocan levels, the authors should be evaluated to determine whether there is any correlation
between endocan and MES in patients with UC .
assistant