Reviewer’s report
Title: Whipple disease diagnosed by enteroscopy: First case report in Colombia of an underdiagnosed
disease and literature review.
Version: 0 Date: 26 Feb 2020
Reviewer: Paolo Usai Satta
Reviewer's report:
This  case  report  describes  a  female  patient  with  a  suspected  Whipple's  disease  diagnosed  by
enteroscopy.Several points need a clarification:
1. Concerning the abstract it is not clear the sequence of endoscopic studies and the enteroscopic role
and the enteroscopic findings are not specified.
2.  Standard  esophagogastroduodenoscopy evidenced  an  erythematous  pangastropathy with  normal
findings  in  the  biopsies:  were  normal  hystological  results  also  in  the  duodenum?Were  multiple
duodenal biopsies performed?
3.Were hystological signs of Whipple's disease achieved in duodenum or in jejunum biopsies by
eneteroscopy?
4. Should capsule enteroscopy have a role more prognostic than diagnostic?
5. Where is the literature review? A specific paragraph should be prepared before the discussion and the
authors should specify if this review concerns Whipple's disease or only the role of enteroscopy in this
condition.
6. A revision of English language is needed.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
Reviewer’s report
Title: Whipple disease diagnosed by enteroscopy: First case report in Colombia of an underdiagnosed
disease and literature review.
Version: 0 Date: 26 Feb 2020
Reviewer: Paolo Usai Satta
Reviewer's report:
This  case  report  describes  a  female  patient  with  a  suspected  Whipple's  disease  diagnosed  by
enteroscopy.Several points need a clarification:
1. Concerning the abstract it is not clear the sequence of endoscopic studies and the enteroscopic role
and the enteroscopic findings are not specified.
2.  Standard  esophagogastroduodenoscopy evidenced  an  erythematous  pangastropathy with  normal
findings  in  the  biopsies:  were  normal  hystological  results  also  in  the  duodenum?Were  multiple
duodenal biopsies performed?
3.Were hystological signs of Whipple's disease achieved in duodenum or in jejunum biopsies by
eneteroscopy?
4. Should capsule enteroscopy have a role more prognostic than diagnostic?
5. Where is the literature review? A specific paragraph should be prepared before the discussion and the
authors should specify if this review concerns Whipple's disease or only the role of enteroscopy in this
condition.
6. A revision of English language is needed.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’s report
Title: Whipple disease diagnosed by enteroscopy: First case report in Colombia of an underdiagnosed
disease and literature review.
Version: 0 Date: 26 Feb 2020
Reviewer: Paolo Usai Satta
Reviewer's report:
This  case  report  describes  a  female  patient  with  a  suspected  Whipple's  disease  diagnosed  by
enteroscopy.Several points need a clarification:
1. Concerning the abstract it is not clear the sequence of endoscopic studies and the enteroscopic role
and the enteroscopic findings are not specified.
2.  Standard  esophagogastroduodenoscopy evidenced  an  erythematous  pangastropathy with  normal
findings  in  the  biopsies:  were  normal  hystological  results  also  in  the  duodenum?Were  multiple
duodenal biopsies performed?
3.Were hystological signs of Whipple's disease achieved in duodenum or in jejunum biopsies by
eneteroscopy?
4. Should capsule enteroscopy have a role more prognostic than diagnostic?
5. Where is the literature review? A specific paragraph should be prepared before the discussion and the
authors should specify if this review concerns Whipple's disease or only the role of enteroscopy in this
condition.
6. A revision of English language is needed.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
No
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If  an  additional  statistical  review  is  recommended,  please  specify  what  aspects  require  further
assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If
your reply is yes to any, please give details below.
I declare that I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
assistant