Reviewer's report
Title:The Association Between Celiac Disease and Eosinophilic Esophagitis in
Children and Adults
Version: 1Date:14 February 2013
Reviewer: Peter Green
Reviewer's report:
In this study the authors have examined the association af EoE and celiac
disease in a population based study.
Major points that need to be addressed.
The most obvious issue is that pediatric gastroenterologists routinely biopsy the
entire upper GI tract, while adult GI doctors rarely do this. The authors could
examine this and find out the percent of pediatric patients with both biopsies of
the esophagus and duodenum and compare this with the adult data.
The data is only as good as the diagnosing physicians. We have no idea from the
data how good the physicians are at diagnosing both EoE and CD. The
prevalence of both conditions (EoE and CD) in the study population needs to be
compared to other North american population derived data / study results. For
EoE the authors can compare the EoE prevalence to Olmsted County data and
for CD the authors can compare to US derived NHANES data from the recent
publication from the Mayo Clinic that demonstrated that CD occurs in ~0.7% of
the population with only 17% aware that they have CD.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:The Association Between Celiac Disease and Eosinophilic Esophagitis in
Children and Adults
Version: 1Date:14 February 2013
Reviewer: Peter Green
Reviewer's report:
In this study the authors have examined the association af EoE and celiac
disease in a population based study.
Major points that need to be addressed.
The most obvious issue is that pediatric gastroenterologists routinely biopsy the
entire upper GI tract, while adult GI doctors rarely do this. The authors could
examine this and find out the percent of pediatric patients with both biopsies of
the esophagus and duodenum and compare this with the adult data.
The data is only as good as the diagnosing physicians. We have no idea from the
data how good the physicians are at diagnosing both EoE and CD. The
prevalence of both conditions (EoE and CD) in the study population needs to be
compared to other North american population derived data / study results. For
EoE the authors can compare the EoE prevalence to Olmsted County data and
for CD the authors can compare to US derived NHANES data from the recent
publication from the Mayo Clinic that demonstrated that CD occurs in ~0.7% of
the population with only 17% aware that they have CD.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:The Association Between Celiac Disease and Eosinophilic Esophagitis in
Children and Adults
Version: 1Date:14 February 2013
Reviewer: Peter Green
Reviewer's report:
In this study the authors have examined the association af EoE and celiac
disease in a population based study.
Major points that need to be addressed.
The most obvious issue is that pediatric gastroenterologists routinely biopsy the
entire upper GI tract, while adult GI doctors rarely do this. The authors could
examine this and find out the percent of pediatric patients with both biopsies of
the esophagus and duodenum and compare this with the adult data.
The data is only as good as the diagnosing physicians. We have no idea from the
data how good the physicians are at diagnosing both EoE and CD. The
prevalence of both conditions (EoE and CD) in the study population needs to be
compared to other North american population derived data / study results. For
EoE the authors can compare the EoE prevalence to Olmsted County data and
for CD the authors can compare to US derived NHANES data from the recent
publication from the Mayo Clinic that demonstrated that CD occurs in ~0.7% of
the population with only 17% aware that they have CD.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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