Title: Prognostic Value of Tumor Deposits and Positive Lymph Nodes in Colorectal Cancer
Surgery: Improved Staging for Long-Term Prognosis
Version: 3 Date: 22 Dec 2024
Reviewer's report:
The aim of the study is very interesting and current with important implications in clinical
practice, especially surgical and oncology.The introduction adequately presents the aim of
the work, also citing the literature regarding other types of neoplasms on the same topic.
The Materials and Methods are well described with a detailed subdivision into paragraphs.
The inclusion and exclusion criteria are good. The results, with the precise help of statistical
studies, report clear and important data. Tables and figures correctly reported and useful for a
better understanding of the results obtained. Relevant and well-explained discussion, updated
bibliography.  I would recommend:
1) In table 1, patients with TD were classified as N0, N1, and N2 in the N stage.According to
the eighth edition of TNM staging of malignant tumors released by the UICC, tumor deposition
(TD) (+) patients without regional lymph node metastases are classified as N1c, as described in
your article. So what is the definition of N0 in the N stage for TD-positive patients in Table 1?
Title: Prognostic Value of Tumor Deposits and Positive Lymph Nodes in Colorectal Cancer
Surgery: Improved Staging for Long-Term Prognosis
Version: 3 Date: 22 Dec 2024
Reviewer's report:
The aim of the study is very interesting and current with important implications in clinical
practice, especially surgical and oncology.The introduction adequately presents the aim of
the work, also citing the literature regarding other types of neoplasms on the same topic.
The Materials and Methods are well described with a detailed subdivision into paragraphs.
The inclusion and exclusion criteria are good. The results, with the precise help of statistical
studies, report clear and important data. Tables and figures correctly reported and useful for a
better understanding of the results obtained. Relevant and well-explained discussion, updated
bibliography.  I would recommend:
1) In table 1, patients with TD were classified as N0, N1, and N2 in the N stage.According to
the eighth edition of TNM staging of malignant tumors released by the UICC, tumor deposition
(TD) (+) patients without regional lymph node metastases are classified as N1c, as described in
your article. So what is the definition of N0 in the N stage for TD-positive patients in Table 1?
Please review this paper.
user
Title: Prognostic Value of Tumor Deposits and Positive Lymph Nodes in Colorectal Cancer
Surgery: Improved Staging for Long-Term Prognosis
Version: 3 Date: 22 Dec 2024
Reviewer's report:
The aim of the study is very interesting and current with important implications in clinical
practice, especially surgical and oncology.The introduction adequately presents the aim of
the work, also citing the literature regarding other types of neoplasms on the same topic.
The Materials and Methods are well described with a detailed subdivision into paragraphs.
The inclusion and exclusion criteria are good. The results, with the precise help of statistical
studies, report clear and important data. Tables and figures correctly reported and useful for a
better understanding of the results obtained. Relevant and well-explained discussion, updated
bibliography.  I would recommend:
1) In table 1, patients with TD were classified as N0, N1, and N2 in the N stage.According to
the eighth edition of TNM staging of malignant tumors released by the UICC, tumor deposition
(TD) (+) patients without regional lymph node metastases are classified as N1c, as described in
your article. So what is the definition of N0 in the N stage for TD-positive patients in Table 1?
assistant