Title: Analysis of the Correlation between Defunctioning Stoma and Postoperative Low
Anterior Resection Syndrome in Rectal Cancer#A prospective cohort study
Version: 1 Date: 03 Jun 2024
Reviewer's report:
It is a great pleasure to review the article titled "Analysis of the Correlation between
Defunctioning Stoma and Postoperative Low Anterior Resection Syndrome in Rectal Cancer:
A prospective cohort study" by Yuhan Qi et al. This is an interesting article and well-designed;
however, I have some concerns that I should share with the authors.
Firstly, the article should be edited for grammar, sentence structure, and improved English
writing by a native English language specialist, as there are some typos present.
In the abstract, please provide an explanation of LARS first, and then use the LARS abbreviation
thereafter.
In the introduction, in the third sentence, you used the word "anastomotic" twice; did you mean
"anastomotic leakage"? It's not clear.
In the method section, please provide some information about the preoperative neoadjuvant
treatment protocol (such as short-term radiotherapy, long-term chemoradiotherapy, etc.). Did
you use open, laparoscopic, and robotic surgeries? Please provide some information on this as
well. Did you perform preoperative mechanical bowel cleaning or pre/perop antibiotic therapy?
Please mention these issues in the method section.
Regarding the results, what were the TNM stages in your patients? In Table 2, you mentioned
only 1 patient with anastomotic leakage; I think there might be an error as only 1 patient out
of 480 experienced anastomotic leakage. The occurrence of anastomotic leakage in world-class
centers after rectal cancer surgeries ranges from 5% to 15%. Please check your data carefully.
Also, what was the median stoma closure time in your study?
In the discussion, please add the limitations and strengths of your study to the end of the
discussion part, before the conclusion.
Please provide some more references regarding rectal cancer surgery techniques, etc. I have
some newly published article suggestions that you can use.
In the introduction, in the second sentence, you can add the phrase "improving the neoadjuvant
chemoradiotherapy treatment" as well. You can use the following articles as references for the
second sentence:
This should provide a more comprehensive and detailed review of the article.
Shadmanov N, Aliyev V, Piozzi GN, Bak#r B, Goksel S, Asoglu O. Perioperative and long-term
oncological outcomes of robotic versus laparoscopic total mesorectal excision: a retrospective
study of 672 patients. J Robot Surg. 2024 Mar 30;18(1):144. doi: 10.1007/s11701-024-01922-
w. PMID: 38554211.
Piozzi GN, Baek SJ, Kwak JM, Kim J, Kim SH. Anus-Preserving Surgery in Advanced
Low-Lying Rectal Cancer: A Perspective on Oncological Safety of Intersphincteric Resection.
Cancers (Basel). 2021 Sep 24;13(19):4793. doi: 10.3390/cancers13194793. PMID: 34638278;
PMCID: PMC8507715.
Piozzi GN, Khobragade K, Aliyev V, Asoglu O, Bianchi PP, Butiurca VO, Chen WT, Cheong
JY, Choi GS, Coratti A, Denost Q, Fukunaga Y, Gorgun E, Guerra F, Ito M, Khan JS, Kim HJ,
Kim JC, Kinugasa Y, Konishi T, Kuo LJ, Kuzu MA, Lefevre JH, Liang JT, Marks J, Molnar
C, Panis Y, Rouanet P, Rullier E, Saklani A, Spinelli A, Tsarkov P, Tsukamoto S, Weiser
M, Kim SH. International standardization and optimization group for intersphincteric resection
(ISOG-ISR): modified Delphi consensus on anatomy, definition, indication, surgical technique,
specimen description and functional outcome. Colorectal Dis. 2023 Sep;25(9):1896-1909. doi:
10.1111/codi.16704. Epub 2023 Aug 10. PMID: 37563772.
Aliyev V, Piozzi GN, Bulut A, Guven K, Bakir B, Saglam S, Goksel S, Asoglu O. Robotic
vs. laparoscopic intersphincteric resection for low rectal cancer: a case matched study reporting
a median of 7-year long-term oncological and functional outcomes. Updates Surg. 2022
Dec;74(6):1851-1860. doi: 10.1007/s13304-022-01396-1. Epub 2022 Oct 5. PMID: 36198884.
Aliyev V, Piozzi GN, Shadmanov N, Guven K, Bak#r B, Goksel S, Asoglu O. Robotic and
laparoscopic sphincter-saving resections have similar peri-operative, oncological and functional
outcomes in female patients with rectal cancer. Updates Surg. 2023 Dec;75(8):2201-2209. doi:
10.1007/s13304-023-01686-2. Epub 2023 Nov 13. PMID: 37955804.
Aliyev V, Goksoy B, Goksel S, Guven K, Bak#r B, Saglam S, Asoglu O. Intersphincteric
Resection for Low Rectal Cancer: Parameters Affecting Functional Outcomes and Survival
Rates. Surg Technol Int. 2021 Oct 26;39:166-172. doi: 10.52198/21.STI.39.CR1460. PMID:
34699602.
Asoglu O, Bulut A, Aliyev V, Piozzi GN, Guven K, Bak#r B, Goksel S. Chemoradiation
and consolidation chemotherapy for rectal cancer provides a high rate of organ preservation
with a very good long-term oncological outcome: a single-center cohort series. World J Surg
Oncol. 2022 Nov 10;20(1):358. doi: 10.1186/s12957-022-02816-7. PMID: 36352416; PMCID:
PMC9646475.
Title: Analysis of the Correlation between Defunctioning Stoma and Postoperative Low
Anterior Resection Syndrome in Rectal Cancer#A prospective cohort study
Version: 1 Date: 03 Jun 2024
Reviewer's report:
It is a great pleasure to review the article titled "Analysis of the Correlation between
Defunctioning Stoma and Postoperative Low Anterior Resection Syndrome in Rectal Cancer:
A prospective cohort study" by Yuhan Qi et al. This is an interesting article and well-designed;
however, I have some concerns that I should share with the authors.
Firstly, the article should be edited for grammar, sentence structure, and improved English
writing by a native English language specialist, as there are some typos present.
In the abstract, please provide an explanation of LARS first, and then use the LARS abbreviation
thereafter.
In the introduction, in the third sentence, you used the word "anastomotic" twice; did you mean
"anastomotic leakage"? It's not clear.
In the method section, please provide some information about the preoperative neoadjuvant
treatment protocol (such as short-term radiotherapy, long-term chemoradiotherapy, etc.). Did
you use open, laparoscopic, and robotic surgeries? Please provide some information on this as
well. Did you perform preoperative mechanical bowel cleaning or pre/perop antibiotic therapy?
Please mention these issues in the method section.
Regarding the results, what were the TNM stages in your patients? In Table 2, you mentioned
only 1 patient with anastomotic leakage; I think there might be an error as only 1 patient out
of 480 experienced anastomotic leakage. The occurrence of anastomotic leakage in world-class
centers after rectal cancer surgeries ranges from 5% to 15%. Please check your data carefully.
Also, what was the median stoma closure time in your study?
In the discussion, please add the limitations and strengths of your study to the end of the
discussion part, before the conclusion.
Please provide some more references regarding rectal cancer surgery techniques, etc. I have
some newly published article suggestions that you can use.
In the introduction, in the second sentence, you can add the phrase "improving the neoadjuvant
chemoradiotherapy treatment" as well. You can use the following articles as references for the
second sentence:
This should provide a more comprehensive and detailed review of the article.
Shadmanov N, Aliyev V, Piozzi GN, Bak#r B, Goksel S, Asoglu O. Perioperative and long-term
oncological outcomes of robotic versus laparoscopic total mesorectal excision: a retrospective
study of 672 patients. J Robot Surg. 2024 Mar 30;18(1):144. doi: 10.1007/s11701-024-01922-
w. PMID: 38554211.
Piozzi GN, Baek SJ, Kwak JM, Kim J, Kim SH. Anus-Preserving Surgery in Advanced
Low-Lying Rectal Cancer: A Perspective on Oncological Safety of Intersphincteric Resection.
Cancers (Basel). 2021 Sep 24;13(19):4793. doi: 10.3390/cancers13194793. PMID: 34638278;
PMCID: PMC8507715.
Piozzi GN, Khobragade K, Aliyev V, Asoglu O, Bianchi PP, Butiurca VO, Chen WT, Cheong
JY, Choi GS, Coratti A, Denost Q, Fukunaga Y, Gorgun E, Guerra F, Ito M, Khan JS, Kim HJ,
Kim JC, Kinugasa Y, Konishi T, Kuo LJ, Kuzu MA, Lefevre JH, Liang JT, Marks J, Molnar
C, Panis Y, Rouanet P, Rullier E, Saklani A, Spinelli A, Tsarkov P, Tsukamoto S, Weiser
M, Kim SH. International standardization and optimization group for intersphincteric resection
(ISOG-ISR): modified Delphi consensus on anatomy, definition, indication, surgical technique,
specimen description and functional outcome. Colorectal Dis. 2023 Sep;25(9):1896-1909. doi:
10.1111/codi.16704. Epub 2023 Aug 10. PMID: 37563772.
Aliyev V, Piozzi GN, Bulut A, Guven K, Bakir B, Saglam S, Goksel S, Asoglu O. Robotic
vs. laparoscopic intersphincteric resection for low rectal cancer: a case matched study reporting
a median of 7-year long-term oncological and functional outcomes. Updates Surg. 2022
Dec;74(6):1851-1860. doi: 10.1007/s13304-022-01396-1. Epub 2022 Oct 5. PMID: 36198884.
Aliyev V, Piozzi GN, Shadmanov N, Guven K, Bak#r B, Goksel S, Asoglu O. Robotic and
laparoscopic sphincter-saving resections have similar peri-operative, oncological and functional
outcomes in female patients with rectal cancer. Updates Surg. 2023 Dec;75(8):2201-2209. doi:
10.1007/s13304-023-01686-2. Epub 2023 Nov 13. PMID: 37955804.
Aliyev V, Goksoy B, Goksel S, Guven K, Bak#r B, Saglam S, Asoglu O. Intersphincteric
Resection for Low Rectal Cancer: Parameters Affecting Functional Outcomes and Survival
Rates. Surg Technol Int. 2021 Oct 26;39:166-172. doi: 10.52198/21.STI.39.CR1460. PMID:
34699602.
Asoglu O, Bulut A, Aliyev V, Piozzi GN, Guven K, Bak#r B, Goksel S. Chemoradiation
and consolidation chemotherapy for rectal cancer provides a high rate of organ preservation
with a very good long-term oncological outcome: a single-center cohort series. World J Surg
Oncol. 2022 Nov 10;20(1):358. doi: 10.1186/s12957-022-02816-7. PMID: 36352416; PMCID:
PMC9646475.
Please review this paper.
user
Title: Analysis of the Correlation between Defunctioning Stoma and Postoperative Low
Anterior Resection Syndrome in Rectal Cancer#A prospective cohort study
Version: 1 Date: 03 Jun 2024
Reviewer's report:
It is a great pleasure to review the article titled "Analysis of the Correlation between
Defunctioning Stoma and Postoperative Low Anterior Resection Syndrome in Rectal Cancer:
A prospective cohort study" by Yuhan Qi et al. This is an interesting article and well-designed;
however, I have some concerns that I should share with the authors.
Firstly, the article should be edited for grammar, sentence structure, and improved English
writing by a native English language specialist, as there are some typos present.
In the abstract, please provide an explanation of LARS first, and then use the LARS abbreviation
thereafter.
In the introduction, in the third sentence, you used the word "anastomotic" twice; did you mean
"anastomotic leakage"? It's not clear.
In the method section, please provide some information about the preoperative neoadjuvant
treatment protocol (such as short-term radiotherapy, long-term chemoradiotherapy, etc.). Did
you use open, laparoscopic, and robotic surgeries? Please provide some information on this as
well. Did you perform preoperative mechanical bowel cleaning or pre/perop antibiotic therapy?
Please mention these issues in the method section.
Regarding the results, what were the TNM stages in your patients? In Table 2, you mentioned
only 1 patient with anastomotic leakage; I think there might be an error as only 1 patient out
of 480 experienced anastomotic leakage. The occurrence of anastomotic leakage in world-class
centers after rectal cancer surgeries ranges from 5% to 15%. Please check your data carefully.
Also, what was the median stoma closure time in your study?
In the discussion, please add the limitations and strengths of your study to the end of the
discussion part, before the conclusion.
Please provide some more references regarding rectal cancer surgery techniques, etc. I have
some newly published article suggestions that you can use.
In the introduction, in the second sentence, you can add the phrase "improving the neoadjuvant
chemoradiotherapy treatment" as well. You can use the following articles as references for the
second sentence:
This should provide a more comprehensive and detailed review of the article.
Shadmanov N, Aliyev V, Piozzi GN, Bak#r B, Goksel S, Asoglu O. Perioperative and long-term
oncological outcomes of robotic versus laparoscopic total mesorectal excision: a retrospective
study of 672 patients. J Robot Surg. 2024 Mar 30;18(1):144. doi: 10.1007/s11701-024-01922-
w. PMID: 38554211.
Piozzi GN, Baek SJ, Kwak JM, Kim J, Kim SH. Anus-Preserving Surgery in Advanced
Low-Lying Rectal Cancer: A Perspective on Oncological Safety of Intersphincteric Resection.
Cancers (Basel). 2021 Sep 24;13(19):4793. doi: 10.3390/cancers13194793. PMID: 34638278;
PMCID: PMC8507715.
Piozzi GN, Khobragade K, Aliyev V, Asoglu O, Bianchi PP, Butiurca VO, Chen WT, Cheong
JY, Choi GS, Coratti A, Denost Q, Fukunaga Y, Gorgun E, Guerra F, Ito M, Khan JS, Kim HJ,
Kim JC, Kinugasa Y, Konishi T, Kuo LJ, Kuzu MA, Lefevre JH, Liang JT, Marks J, Molnar
C, Panis Y, Rouanet P, Rullier E, Saklani A, Spinelli A, Tsarkov P, Tsukamoto S, Weiser
M, Kim SH. International standardization and optimization group for intersphincteric resection
(ISOG-ISR): modified Delphi consensus on anatomy, definition, indication, surgical technique,
specimen description and functional outcome. Colorectal Dis. 2023 Sep;25(9):1896-1909. doi:
10.1111/codi.16704. Epub 2023 Aug 10. PMID: 37563772.
Aliyev V, Piozzi GN, Bulut A, Guven K, Bakir B, Saglam S, Goksel S, Asoglu O. Robotic
vs. laparoscopic intersphincteric resection for low rectal cancer: a case matched study reporting
a median of 7-year long-term oncological and functional outcomes. Updates Surg. 2022
Dec;74(6):1851-1860. doi: 10.1007/s13304-022-01396-1. Epub 2022 Oct 5. PMID: 36198884.
Aliyev V, Piozzi GN, Shadmanov N, Guven K, Bak#r B, Goksel S, Asoglu O. Robotic and
laparoscopic sphincter-saving resections have similar peri-operative, oncological and functional
outcomes in female patients with rectal cancer. Updates Surg. 2023 Dec;75(8):2201-2209. doi:
10.1007/s13304-023-01686-2. Epub 2023 Nov 13. PMID: 37955804.
Aliyev V, Goksoy B, Goksel S, Guven K, Bak#r B, Saglam S, Asoglu O. Intersphincteric
Resection for Low Rectal Cancer: Parameters Affecting Functional Outcomes and Survival
Rates. Surg Technol Int. 2021 Oct 26;39:166-172. doi: 10.52198/21.STI.39.CR1460. PMID:
34699602.
Asoglu O, Bulut A, Aliyev V, Piozzi GN, Guven K, Bak#r B, Goksel S. Chemoradiation
and consolidation chemotherapy for rectal cancer provides a high rate of organ preservation
with a very good long-term oncological outcome: a single-center cohort series. World J Surg
Oncol. 2022 Nov 10;20(1):358. doi: 10.1186/s12957-022-02816-7. PMID: 36352416; PMCID:
PMC9646475.
assistant