Reviewer ’s report  
 
Title: Successful Treatment of Pyoderma Gangrenosum in a Patient with A utoimmune 
Hepatitis.A  case report and review of the literature.  
 
Version: 0 Date: 24 Aug 2015  
 
Reviewer: Renumathy Dhanasekaran  
 
Reviewer ’s report:  
 
The case report on a patient with pyoderma gangrenosum and auto immune hepatitis is well 
written and highlights an interesting association. Some minor changes have been suggested for 
author review.  
 
1. Case Presentation (page 4, line 26) do the authors mean anti nuclear antibody (ANA) and 
not anti neutrophillic antibod y) 
 
2. Figure 3 Please use arrow marks to point to the intradermal abscesses mentioned in the 
legend. Please expand the legend to explain more histopathologic details.  
 
3. There is some evidence to support that PG can be treated with Azathioprine, so the 
authors should add to discussion a comment on why this patient had to be switched to 
Cycosporine from Azathioprine.  
 
4. Please consider displaying all the images of the ulcer as one figure in a panel with the 
timelines marked in legend. For eg. Figure 1a at  presentation, 1b at 6months and so forth.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please  specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in th e manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of wri tten English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received rei mbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content o f the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any  non-financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing i nterests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Successful Treatment of Pyoderma Gangrenosum in a Patient with A utoimmune 
Hepatitis.A  case report and review of the literature.  
 
Version: 0 Date: 24 Aug 2015  
 
Reviewer: Renumathy Dhanasekaran  
 
Reviewer ’s report:  
 
The case report on a patient with pyoderma gangrenosum and auto immune hepatitis is well 
written and highlights an interesting association. Some minor changes have been suggested for 
author review.  
 
1. Case Presentation (page 4, line 26) do the authors mean anti nuclear antibody (ANA) and 
not anti neutrophillic antibod y) 
 
2. Figure 3 Please use arrow marks to point to the intradermal abscesses mentioned in the 
legend. Please expand the legend to explain more histopathologic details.  
 
3. There is some evidence to support that PG can be treated with Azathioprine, so the 
authors should add to discussion a comment on why this patient had to be switched to 
Cycosporine from Azathioprine.  
 
4. Please consider displaying all the images of the ulcer as one figure in a panel with the 
timelines marked in legend. For eg. Figure 1a at  presentation, 1b at 6months and so forth.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please  specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in th e manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of wri tten English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received rei mbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content o f the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any  non-financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing i nterests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Successful Treatment of Pyoderma Gangrenosum in a Patient with A utoimmune 
Hepatitis.A  case report and review of the literature.  
 
Version: 0 Date: 24 Aug 2015  
 
Reviewer: Renumathy Dhanasekaran  
 
Reviewer ’s report:  
 
The case report on a patient with pyoderma gangrenosum and auto immune hepatitis is well 
written and highlights an interesting association. Some minor changes have been suggested for 
author review.  
 
1. Case Presentation (page 4, line 26) do the authors mean anti nuclear antibody (ANA) and 
not anti neutrophillic antibod y) 
 
2. Figure 3 Please use arrow marks to point to the intradermal abscesses mentioned in the 
legend. Please expand the legend to explain more histopathologic details.  
 
3. There is some evidence to support that PG can be treated with Azathioprine, so the 
authors should add to discussion a comment on why this patient had to be switched to 
Cycosporine from Azathioprine.  
 
4. Please consider displaying all the images of the ulcer as one figure in a panel with the 
timelines marked in legend. For eg. Figure 1a at  presentation, 1b at 6months and so forth.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please  specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in th e manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of wri tten English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received rei mbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content o f the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any  non-financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing i nterests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant