Title: Association between the LRP5 rs556442 gene polymorphism and the risks of NAFLD
and CHD in a Chinese Han population
Version: 1 Date: 29 Jan 2022
Reviewer's report:
The manuscript was interesting and well written but there are some points that should be
addressed
1- Although the manuscript has a language certificate but it has some writing and grammar errors
for example:
Line 22: The comma before “this” should be changed to point
Line 257: This findings should be changed to these findings
The authors should explain the rationale for selecting LRP5 rs556442 among other variants in
the same gene.
Table 1 title: “characteristicses” should be changed to “characteristics”
2- There are some mistakes in the citations:
Line 76: Nima et al. is should be changed to Montazeri-Najafabady et al.
Line 80 and 220: Elham et al. should be changed to Adabi et al.
3- Give the eligibility criteria, and the sources and methods of case ascertainment
and control selection
4- It is better to explain the statistical analyses presented in Table 3 below the table.
5- Describe any efforts to address potential sources of bias
6- Explain how the sample size was calculated
7- It is better to report the results for Hardy-Weinberg equilibrium in the text instead of table
8-It is better to report the main findings of the study in the first paragraph of discussion section.
9- It is important to include some discussion on the implications of other polymorphism in strong
LD with the present variant
Title: Association between the LRP5 rs556442 gene polymorphism and the risks of NAFLD
and CHD in a Chinese Han population
Version: 1 Date: 29 Jan 2022
Reviewer's report:
The manuscript was interesting and well written but there are some points that should be
addressed
1- Although the manuscript has a language certificate but it has some writing and grammar errors
for example:
Line 22: The comma before “this” should be changed to point
Line 257: This findings should be changed to these findings
The authors should explain the rationale for selecting LRP5 rs556442 among other variants in
the same gene.
Table 1 title: “characteristicses” should be changed to “characteristics”
2- There are some mistakes in the citations:
Line 76: Nima et al. is should be changed to Montazeri-Najafabady et al.
Line 80 and 220: Elham et al. should be changed to Adabi et al.
3- Give the eligibility criteria, and the sources and methods of case ascertainment
and control selection
4- It is better to explain the statistical analyses presented in Table 3 below the table.
5- Describe any efforts to address potential sources of bias
6- Explain how the sample size was calculated
7- It is better to report the results for Hardy-Weinberg equilibrium in the text instead of table
8-It is better to report the main findings of the study in the first paragraph of discussion section.
9- It is important to include some discussion on the implications of other polymorphism in strong
LD with the present variant
Please review this paper.
user
Title: Association between the LRP5 rs556442 gene polymorphism and the risks of NAFLD
and CHD in a Chinese Han population
Version: 1 Date: 29 Jan 2022
Reviewer's report:
The manuscript was interesting and well written but there are some points that should be
addressed
1- Although the manuscript has a language certificate but it has some writing and grammar errors
for example:
Line 22: The comma before “this” should be changed to point
Line 257: This findings should be changed to these findings
The authors should explain the rationale for selecting LRP5 rs556442 among other variants in
the same gene.
Table 1 title: “characteristicses” should be changed to “characteristics”
2- There are some mistakes in the citations:
Line 76: Nima et al. is should be changed to Montazeri-Najafabady et al.
Line 80 and 220: Elham et al. should be changed to Adabi et al.
3- Give the eligibility criteria, and the sources and methods of case ascertainment
and control selection
4- It is better to explain the statistical analyses presented in Table 3 below the table.
5- Describe any efforts to address potential sources of bias
6- Explain how the sample size was calculated
7- It is better to report the results for Hardy-Weinberg equilibrium in the text instead of table
8-It is better to report the main findings of the study in the first paragraph of discussion section.
9- It is important to include some discussion on the implications of other polymorphism in strong
LD with the present variant
assistant