Title: Genetic evidence causally linking gastroesophageal reflux disease to cholecystitis#A two-
sample Mendelian randomization study
Version: 1 Date: 22 Jun 2024
Reviewer's report:
The topic is interesting and the paper is quite well written.  The article covers a very interesting
and current topic. I think that the manuscript has been improved in agreement with previous
reviewers' comments. In my opinion, several parts  were improved, I have few comments:
1) 5. Conclusions
In summary, our MR analysis establishes a causal relationship between GERD and cholecystitis,
particularly an increased risk of cholecystitis in patients with genetically-predicted GERD.
However, further studies are required to elucidate the fundamental mechanisms underlying this
causal association. I suggest to improve this paragraph and underline the novelty of the sudy
and the possible clinical implications
Title: Genetic evidence causally linking gastroesophageal reflux disease to cholecystitis#A two-
sample Mendelian randomization study
Version: 1 Date: 22 Jun 2024
Reviewer's report:
The topic is interesting and the paper is quite well written.  The article covers a very interesting
and current topic. I think that the manuscript has been improved in agreement with previous
reviewers' comments. In my opinion, several parts  were improved, I have few comments:
1) 5. Conclusions
In summary, our MR analysis establishes a causal relationship between GERD and cholecystitis,
particularly an increased risk of cholecystitis in patients with genetically-predicted GERD.
However, further studies are required to elucidate the fundamental mechanisms underlying this
causal association. I suggest to improve this paragraph and underline the novelty of the sudy
and the possible clinical implications
Please review this paper.
user
Title: Genetic evidence causally linking gastroesophageal reflux disease to cholecystitis#A two-
sample Mendelian randomization study
Version: 1 Date: 22 Jun 2024
Reviewer's report:
The topic is interesting and the paper is quite well written.  The article covers a very interesting
and current topic. I think that the manuscript has been improved in agreement with previous
reviewers' comments. In my opinion, several parts  were improved, I have few comments:
1) 5. Conclusions
In summary, our MR analysis establishes a causal relationship between GERD and cholecystitis,
particularly an increased risk of cholecystitis in patients with genetically-predicted GERD.
However, further studies are required to elucidate the fundamental mechanisms underlying this
causal association. I suggest to improve this paragraph and underline the novelty of the sudy
and the possible clinical implications
assistant