Reviewer's report
Title:Examination of the gastric enteric nervous system and muscle in patients
with diabetic gastroparesis
Version: 1Date:9 October 2007
Reviewer: Michael Horowitz
Reviewer's report:
This is a well performed and presented study that represents a useful addition to
existing literature. The absence of formal assessment of autonomic function is a
limitation. My comments all relate to minor / discretionary revision.
(i) p 3,4 It would be helpful to provide additional information about glycaemic
control (glycated haemoglobin), diabetes management and body weight / BMI in
both patients if available. Case I is unusual because of the short duration of
diabetes.
The results of the gastric emptying measurements should ideally be included.
(ii) p4 When was the response to gastric electrical stimulation evaluated?
(iii) In the ‘discussion’ it may be appropriate to comment more specifically about
the effects of acute hyperglycaemia. (eg. Gastroenterology 1997:113;60-6), and
insulin-induced hypoglycaemia (eg. J. Clin Endocrinol Metab 2005:90;4489-95),
on gastric emptying . It is likely that gastroparesis predisposes to postprandial
hypoglycaemia in insulin-treated patients (Neurogastroenterol Motil
2005:18;405-7)
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
Reviewer's report
Title:Examination of the gastric enteric nervous system and muscle in patients
with diabetic gastroparesis
Version: 1Date:9 October 2007
Reviewer: Michael Horowitz
Reviewer's report:
This is a well performed and presented study that represents a useful addition to
existing literature. The absence of formal assessment of autonomic function is a
limitation. My comments all relate to minor / discretionary revision.
(i) p 3,4 It would be helpful to provide additional information about glycaemic
control (glycated haemoglobin), diabetes management and body weight / BMI in
both patients if available. Case I is unusual because of the short duration of
diabetes.
The results of the gastric emptying measurements should ideally be included.
(ii) p4 When was the response to gastric electrical stimulation evaluated?
(iii) In the ‘discussion’ it may be appropriate to comment more specifically about
the effects of acute hyperglycaemia. (eg. Gastroenterology 1997:113;60-6), and
insulin-induced hypoglycaemia (eg. J. Clin Endocrinol Metab 2005:90;4489-95),
on gastric emptying . It is likely that gastroparesis predisposes to postprandial
hypoglycaemia in insulin-treated patients (Neurogastroenterol Motil
2005:18;405-7)
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Examination of the gastric enteric nervous system and muscle in patients
with diabetic gastroparesis
Version: 1Date:9 October 2007
Reviewer: Michael Horowitz
Reviewer's report:
This is a well performed and presented study that represents a useful addition to
existing literature. The absence of formal assessment of autonomic function is a
limitation. My comments all relate to minor / discretionary revision.
(i) p 3,4 It would be helpful to provide additional information about glycaemic
control (glycated haemoglobin), diabetes management and body weight / BMI in
both patients if available. Case I is unusual because of the short duration of
diabetes.
The results of the gastric emptying measurements should ideally be included.
(ii) p4 When was the response to gastric electrical stimulation evaluated?
(iii) In the ‘discussion’ it may be appropriate to comment more specifically about
the effects of acute hyperglycaemia. (eg. Gastroenterology 1997:113;60-6), and
insulin-induced hypoglycaemia (eg. J. Clin Endocrinol Metab 2005:90;4489-95),
on gastric emptying . It is likely that gastroparesis predisposes to postprandial
hypoglycaemia in insulin-treated patients (Neurogastroenterol Motil
2005:18;405-7)
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
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