Reviewer ’s report  
 
Title: Effect of Helicobacter pylori Eradication on Reflux Esop hagitis and GERD Symptoms 
after Endoscopic Resection of  Gastric Neoplasm: A Single -Center Prospective Study  
 
Version: 0 Date: 17 Mar 2020  
 
Reviewer: Vincenzo Savarino  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The athors have performed this stud y in order to assess whether the eradication of H. pylori 
infection determines a significant increase in reflux esophagitis and GERD symptoms after 
eradication of the germ in patients who underwent endoscopic resection of early gastric cancer. 
The study is  original and the methodology is good, but some features need to be improved:  
 
- The percentages of success of eradication therapy are not clear through the text  
 
- The authors should consider only typical reflux symptoms in the methods section, because 
extra-esophageal symptoms do not necessarily pertain to GERD  
 
- The number of patients with RE is so small that this reviewer does not think that the analysis of 
variables associated with this disease is appropriate  
 
- The functional evaluation of esophageal EGJ  would have been useful to corroborate the results 
of the study  
 
- Other relevant physiologic studies of the esophagus in patients with and without H. pylori 
infection should be quoted (for instance Zentilin P, Aliment Pharmacol Ther 2003).  
 
- English langua ge should be improved  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
 
 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in t he manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of  written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or share s in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you rece ived reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing intere sts in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
 
 
 
I agree to the open pe er review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named re port 
including any attachments I upload will be posted on the website along with the auth ors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be includ ed as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Effect of Helicobacter pylori Eradication on Reflux Esop hagitis and GERD Symptoms 
after Endoscopic Resection of  Gastric Neoplasm: A Single -Center Prospective Study  
 
Version: 0 Date: 17 Mar 2020  
 
Reviewer: Vincenzo Savarino  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The athors have performed this stud y in order to assess whether the eradication of H. pylori 
infection determines a significant increase in reflux esophagitis and GERD symptoms after 
eradication of the germ in patients who underwent endoscopic resection of early gastric cancer. 
The study is  original and the methodology is good, but some features need to be improved:  
 
- The percentages of success of eradication therapy are not clear through the text  
 
- The authors should consider only typical reflux symptoms in the methods section, because 
extra-esophageal symptoms do not necessarily pertain to GERD  
 
- The number of patients with RE is so small that this reviewer does not think that the analysis of 
variables associated with this disease is appropriate  
 
- The functional evaluation of esophageal EGJ  would have been useful to corroborate the results 
of the study  
 
- Other relevant physiologic studies of the esophagus in patients with and without H. pylori 
infection should be quoted (for instance Zentilin P, Aliment Pharmacol Ther 2003).  
 
- English langua ge should be improved  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
 
 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in t he manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of  written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or share s in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you rece ived reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing intere sts in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
 
 
 
I agree to the open pe er review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named re port 
including any attachments I upload will be posted on the website along with the auth ors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be includ ed as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Effect of Helicobacter pylori Eradication on Reflux Esop hagitis and GERD Symptoms 
after Endoscopic Resection of  Gastric Neoplasm: A Single -Center Prospective Study  
 
Version: 0 Date: 17 Mar 2020  
 
Reviewer: Vincenzo Savarino  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The athors have performed this stud y in order to assess whether the eradication of H. pylori 
infection determines a significant increase in reflux esophagitis and GERD symptoms after 
eradication of the germ in patients who underwent endoscopic resection of early gastric cancer. 
The study is  original and the methodology is good, but some features need to be improved:  
 
- The percentages of success of eradication therapy are not clear through the text  
 
- The authors should consider only typical reflux symptoms in the methods section, because 
extra-esophageal symptoms do not necessarily pertain to GERD  
 
- The number of patients with RE is so small that this reviewer does not think that the analysis of 
variables associated with this disease is appropriate  
 
- The functional evaluation of esophageal EGJ  would have been useful to corroborate the results 
of the study  
 
- Other relevant physiologic studies of the esophagus in patients with and without H. pylori 
infection should be quoted (for instance Zentilin P, Aliment Pharmacol Ther 2003).  
 
- English langua ge should be improved  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
 
 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in t he manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of  written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or share s in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you rece ived reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing intere sts in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
 
 
 
I agree to the open pe er review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named re port 
including any attachments I upload will be posted on the website along with the auth ors' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be includ ed as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant