Title: Analysis of the status and risk factors for Helicobacter pylori infection and drug resistance
in the Lianyungang area, China
Version: 0 Date: 31 Dec 2024
Reviewer's report:
This manuscript by Yang et al. investigated the prevalence and mechanisms of antibiotic
resistance in H. pylori from the Lianyungang area. However, the study primarily employed
molecular methods for analysis and did not include H. pylori cultivation to verify phenotypic
characteristics. Therefore, I have the following comments:
Major comments:
1. The study limitations should address the potential inconsistency between phenotype and
genotype. The absence of H. pylori cultivation and subsequent antibiotic susceptibility testing
should be noted as a limitation of the study.
2. In Table S2, it is recommended to categorize the data into CagA+, VacA+, CagA+/VacA
+, and CagA-/VacA- groups. Additionally, previous studies have reported correlations between
CagA/VacA genotypes and disease outcomes, which should be further explored in this study.
Minor comments:
Please revise the formatting of gene names and bacterial species names throughout the
manuscript. For example, H. pylori should be italicized, and "23SrRNA" should be written as
"23S rRNA."
Title: Analysis of the status and risk factors for Helicobacter pylori infection and drug resistance
in the Lianyungang area, China
Version: 0 Date: 31 Dec 2024
Reviewer's report:
This manuscript by Yang et al. investigated the prevalence and mechanisms of antibiotic
resistance in H. pylori from the Lianyungang area. However, the study primarily employed
molecular methods for analysis and did not include H. pylori cultivation to verify phenotypic
characteristics. Therefore, I have the following comments:
Major comments:
1. The study limitations should address the potential inconsistency between phenotype and
genotype. The absence of H. pylori cultivation and subsequent antibiotic susceptibility testing
should be noted as a limitation of the study.
2. In Table S2, it is recommended to categorize the data into CagA+, VacA+, CagA+/VacA
+, and CagA-/VacA- groups. Additionally, previous studies have reported correlations between
CagA/VacA genotypes and disease outcomes, which should be further explored in this study.
Minor comments:
Please revise the formatting of gene names and bacterial species names throughout the
manuscript. For example, H. pylori should be italicized, and "23SrRNA" should be written as
"23S rRNA."
Please review this paper.
user
Title: Analysis of the status and risk factors for Helicobacter pylori infection and drug resistance
in the Lianyungang area, China
Version: 0 Date: 31 Dec 2024
Reviewer's report:
This manuscript by Yang et al. investigated the prevalence and mechanisms of antibiotic
resistance in H. pylori from the Lianyungang area. However, the study primarily employed
molecular methods for analysis and did not include H. pylori cultivation to verify phenotypic
characteristics. Therefore, I have the following comments:
Major comments:
1. The study limitations should address the potential inconsistency between phenotype and
genotype. The absence of H. pylori cultivation and subsequent antibiotic susceptibility testing
should be noted as a limitation of the study.
2. In Table S2, it is recommended to categorize the data into CagA+, VacA+, CagA+/VacA
+, and CagA-/VacA- groups. Additionally, previous studies have reported correlations between
CagA/VacA genotypes and disease outcomes, which should be further explored in this study.
Minor comments:
Please revise the formatting of gene names and bacterial species names throughout the
manuscript. For example, H. pylori should be italicized, and "23SrRNA" should be written as
"23S rRNA."
assistant