Reviewer's report
Title:Fecal Lactoferrin in Discriminating Inflammatory Bowel Disease from
Irritable Bowel Syndrome: A Diagnostic Meta-analysis
Version:1Date:2 May 2014
Reviewer: Charles N Bernstein
Reviewer's report:
Major compulsory revisions
1.The authors do not report the actual cut off level of positive fecal lactoferrin
used. Was it the same for all studies included?
2There are 349 subjects included with UC and 365 with CD; it would still be of
interest to conduct separate analyses for UC ad CD since it would be helpful to
know if this test was useful in CD especially
3The authors do not discuss the differences between using fecal lactoferrin and
calprotectin and need to
4The English language of the paper needs to be improved
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Fecal Lactoferrin in Discriminating Inflammatory Bowel Disease from
Irritable Bowel Syndrome: A Diagnostic Meta-analysis
Version:1Date:2 May 2014
Reviewer: Charles N Bernstein
Reviewer's report:
Major compulsory revisions
1.The authors do not report the actual cut off level of positive fecal lactoferrin
used. Was it the same for all studies included?
2There are 349 subjects included with UC and 365 with CD; it would still be of
interest to conduct separate analyses for UC ad CD since it would be helpful to
know if this test was useful in CD especially
3The authors do not discuss the differences between using fecal lactoferrin and
calprotectin and need to
4The English language of the paper needs to be improved
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Fecal Lactoferrin in Discriminating Inflammatory Bowel Disease from
Irritable Bowel Syndrome: A Diagnostic Meta-analysis
Version:1Date:2 May 2014
Reviewer: Charles N Bernstein
Reviewer's report:
Major compulsory revisions
1.The authors do not report the actual cut off level of positive fecal lactoferrin
used. Was it the same for all studies included?
2There are 349 subjects included with UC and 365 with CD; it would still be of
interest to conduct separate analyses for UC ad CD since it would be helpful to
know if this test was useful in CD especially
3The authors do not discuss the differences between using fecal lactoferrin and
calprotectin and need to
4The English language of the paper needs to be improved
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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