Reviewer's report
Title:Intrahepatic Biliary Mucinous Cystic Neoplasms: Clinicoradiological
Characteristics and Surgical Results
Version:2Date:8 February 2015
Reviewer: Terry Lairmore
Reviewer's report:
The manuscript was reviewed for clarity, organization, appropriate grammar,
appropriateness of results/conclusions based on data presented, and scientific
impact/interest. The following comments/criticisms are made:
Minor Essential Revisions:
1. While it is understood that English is not the author's first language, there are
some language/grammatical errors. These are minor but too numerous to list.
The manuscript should be read and corrected by a primary English speaking
author/editor.
2. This is a retrospective review of the clinicopathilogic features of patients with
intrahepatic biliary cystic mucinous neoplasms at a single high volume HPB
center over a 25 year period. This is a rare clinical entity and the current data
review does provide important features of the presentation and imaging features
of these tumors. This manuscript reports one of the largest series of such
patients and therefore adds to the current literature.
3. The clinical and radiographic features are described effectively and in
adequate detail, and the imaging features are illustrated will by the figures. The
typical features of presentation are also well described and useful. There are
inherent limitations to this type of retrospective analysis, specifically the fact that
the study period encompasses a long period with differing surgical approaches,
technology, imaging capabiliites , and pathologic understanding or classification
of the neoplasms described. These limitations cannot be avoided due to the rare
nature of these tumors and the nature of retrospective collection of data.
4. The report of results regarding the usefulness of tumor markers as measured
in cyst fluid or serum is also useful and is reported for a significant percentage of
the tumors in this large collected series. This data is useful and adds to the
current literature.
5. One of the most significant results of the current study is the authors'
conclusion that less than radical resection results in a higher recurrence rate, and
therefore a statement that radical resection is preferred whenever possible. The
manuscipt states that patients included in the study had their extent of hepatic
resection determined by individual factors and surgeon preference. The author's
should state the factors that should be considered in choosing the extent of
surgery. For example, magnitude of comorbid conditions, hepatic reserve or
underlying function, positivity for Hepatitic B or C, etc.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Intrahepatic Biliary Mucinous Cystic Neoplasms: Clinicoradiological
Characteristics and Surgical Results
Version:2Date:8 February 2015
Reviewer: Terry Lairmore
Reviewer's report:
The manuscript was reviewed for clarity, organization, appropriate grammar,
appropriateness of results/conclusions based on data presented, and scientific
impact/interest. The following comments/criticisms are made:
Minor Essential Revisions:
1. While it is understood that English is not the author's first language, there are
some language/grammatical errors. These are minor but too numerous to list.
The manuscript should be read and corrected by a primary English speaking
author/editor.
2. This is a retrospective review of the clinicopathilogic features of patients with
intrahepatic biliary cystic mucinous neoplasms at a single high volume HPB
center over a 25 year period. This is a rare clinical entity and the current data
review does provide important features of the presentation and imaging features
of these tumors. This manuscript reports one of the largest series of such
patients and therefore adds to the current literature.
3. The clinical and radiographic features are described effectively and in
adequate detail, and the imaging features are illustrated will by the figures. The
typical features of presentation are also well described and useful. There are
inherent limitations to this type of retrospective analysis, specifically the fact that
the study period encompasses a long period with differing surgical approaches,
technology, imaging capabiliites , and pathologic understanding or classification
of the neoplasms described. These limitations cannot be avoided due to the rare
nature of these tumors and the nature of retrospective collection of data.
4. The report of results regarding the usefulness of tumor markers as measured
in cyst fluid or serum is also useful and is reported for a significant percentage of
the tumors in this large collected series. This data is useful and adds to the
current literature.
5. One of the most significant results of the current study is the authors'
conclusion that less than radical resection results in a higher recurrence rate, and
therefore a statement that radical resection is preferred whenever possible. The
manuscipt states that patients included in the study had their extent of hepatic
resection determined by individual factors and surgeon preference. The author's
should state the factors that should be considered in choosing the extent of
surgery. For example, magnitude of comorbid conditions, hepatic reserve or
underlying function, positivity for Hepatitic B or C, etc.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Intrahepatic Biliary Mucinous Cystic Neoplasms: Clinicoradiological
Characteristics and Surgical Results
Version:2Date:8 February 2015
Reviewer: Terry Lairmore
Reviewer's report:
The manuscript was reviewed for clarity, organization, appropriate grammar,
appropriateness of results/conclusions based on data presented, and scientific
impact/interest. The following comments/criticisms are made:
Minor Essential Revisions:
1. While it is understood that English is not the author's first language, there are
some language/grammatical errors. These are minor but too numerous to list.
The manuscript should be read and corrected by a primary English speaking
author/editor.
2. This is a retrospective review of the clinicopathilogic features of patients with
intrahepatic biliary cystic mucinous neoplasms at a single high volume HPB
center over a 25 year period. This is a rare clinical entity and the current data
review does provide important features of the presentation and imaging features
of these tumors. This manuscript reports one of the largest series of such
patients and therefore adds to the current literature.
3. The clinical and radiographic features are described effectively and in
adequate detail, and the imaging features are illustrated will by the figures. The
typical features of presentation are also well described and useful. There are
inherent limitations to this type of retrospective analysis, specifically the fact that
the study period encompasses a long period with differing surgical approaches,
technology, imaging capabiliites , and pathologic understanding or classification
of the neoplasms described. These limitations cannot be avoided due to the rare
nature of these tumors and the nature of retrospective collection of data.
4. The report of results regarding the usefulness of tumor markers as measured
in cyst fluid or serum is also useful and is reported for a significant percentage of
the tumors in this large collected series. This data is useful and adds to the
current literature.
5. One of the most significant results of the current study is the authors'
conclusion that less than radical resection results in a higher recurrence rate, and
therefore a statement that radical resection is preferred whenever possible. The
manuscipt states that patients included in the study had their extent of hepatic
resection determined by individual factors and surgeon preference. The author's
should state the factors that should be considered in choosing the extent of
surgery. For example, magnitude of comorbid conditions, hepatic reserve or
underlying function, positivity for Hepatitic B or C, etc.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant