Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 25 Jul 2024
Reviewer's report:
Dear Authors,
Thank you for your diligent revisions and the improvements made to the manuscript. Your
responses to the feedback have significantly enhanced the quality of the work. I particularly
appreciate the following:
Abstract and Methods Clarification:
The correction in the abstract to reflect that the purpose was to identify factors associated
with survival in synchronous colorectal cancer using univariate and multivariate Cox regression
analyses was well done.
Background Section:
The revision to clarify that the tool is for predicting the prognosis (survival) of SCRCs.
Patient and Methods Section:
Including the start and end dates of the training cohort.
Results Section:
Identifying the predictors included in the final model and providing the full model equation has
made the results more transparent.
These revisions are commendable and have greatly strengthened the manuscript. However, there
are two remaining points that need to be addressed:
1- Title:
Please revise the title to "Development and validation of a prognostic model for survival
among…" rather than "predicting prognosis." Including "validation" is essential as your study
encompasses both the development and validation phases, with an excellent job done on the
external validation. This should not be overlooked in the title.
2- Equations:
Please exchange the equations for the hazard  h(t#X) with the equations for survival probability
S(t#X).
Addressing these points will further enhance the clarity and accuracy of your manuscript. I look
forward to your revised submission.
Best regards,
Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 25 Jul 2024
Reviewer's report:
Dear Authors,
Thank you for your diligent revisions and the improvements made to the manuscript. Your
responses to the feedback have significantly enhanced the quality of the work. I particularly
appreciate the following:
Abstract and Methods Clarification:
The correction in the abstract to reflect that the purpose was to identify factors associated
with survival in synchronous colorectal cancer using univariate and multivariate Cox regression
analyses was well done.
Background Section:
The revision to clarify that the tool is for predicting the prognosis (survival) of SCRCs.
Patient and Methods Section:
Including the start and end dates of the training cohort.
Results Section:
Identifying the predictors included in the final model and providing the full model equation has
made the results more transparent.
These revisions are commendable and have greatly strengthened the manuscript. However, there
are two remaining points that need to be addressed:
1- Title:
Please revise the title to "Development and validation of a prognostic model for survival
among…" rather than "predicting prognosis." Including "validation" is essential as your study
encompasses both the development and validation phases, with an excellent job done on the
external validation. This should not be overlooked in the title.
2- Equations:
Please exchange the equations for the hazard  h(t#X) with the equations for survival probability
S(t#X).
Addressing these points will further enhance the clarity and accuracy of your manuscript. I look
forward to your revised submission.
Best regards,
Please review this paper.
user
Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 25 Jul 2024
Reviewer's report:
Dear Authors,
Thank you for your diligent revisions and the improvements made to the manuscript. Your
responses to the feedback have significantly enhanced the quality of the work. I particularly
appreciate the following:
Abstract and Methods Clarification:
The correction in the abstract to reflect that the purpose was to identify factors associated
with survival in synchronous colorectal cancer using univariate and multivariate Cox regression
analyses was well done.
Background Section:
The revision to clarify that the tool is for predicting the prognosis (survival) of SCRCs.
Patient and Methods Section:
Including the start and end dates of the training cohort.
Results Section:
Identifying the predictors included in the final model and providing the full model equation has
made the results more transparent.
These revisions are commendable and have greatly strengthened the manuscript. However, there
are two remaining points that need to be addressed:
1- Title:
Please revise the title to "Development and validation of a prognostic model for survival
among…" rather than "predicting prognosis." Including "validation" is essential as your study
encompasses both the development and validation phases, with an excellent job done on the
external validation. This should not be overlooked in the title.
2- Equations:
Please exchange the equations for the hazard  h(t#X) with the equations for survival probability
S(t#X).
Addressing these points will further enhance the clarity and accuracy of your manuscript. I look
forward to your revised submission.
Best regards,
assistant