Title: Association between gastrointestinal lesions in individuals undergoing gastroscopy and
colonoscopy simultaneously: a retrospective, observational study
Version: 0 Date: 14 Sep 2024
Reviewer's report:
The authors have conducted a large-scale study of gastrointestinal lesions in individuals
undergoing gastroscopy and the relationship with colonoscopy.Although this is an interesting
study, it seems necessary to reconsider the disease definition and analysis methods.
The definition of atrophic gastritis in this study is unclear as to whether it was determined by
endoscopic or pathological diagnosis. The authors state that they used the Kimura-Takemoto
classification to diagnose CAG. However, the details are not described. In many studies, C1
is often omitted from CAG, and the two types C and O are often distinguished. These points
should also be mentioned.
The definition of gastric polyp examined in this study is unclear. Does it refer only to fundic
gland polyps, or does it also include hyperplastic polyps and adenomas? Since the background
gastric mucosa is expected to differ significantly depending on the definition, it is likely to have
a large impact on the relationship with lower GI findings, not just on age and gender.
The authors emphasized that correlations between endoscopic diseases especially  between
conditions like CAG and CPs However, as already mentioned, the underlying mechanism might
be partially associated with H. Pylori infection, and many studies suggested that H. Pylori
infection increased the risk of CPs or CRC. It is unfortunate that H. Pylori was not examined
in this study.
Title: Association between gastrointestinal lesions in individuals undergoing gastroscopy and
colonoscopy simultaneously: a retrospective, observational study
Version: 0 Date: 14 Sep 2024
Reviewer's report:
The authors have conducted a large-scale study of gastrointestinal lesions in individuals
undergoing gastroscopy and the relationship with colonoscopy.Although this is an interesting
study, it seems necessary to reconsider the disease definition and analysis methods.
The definition of atrophic gastritis in this study is unclear as to whether it was determined by
endoscopic or pathological diagnosis. The authors state that they used the Kimura-Takemoto
classification to diagnose CAG. However, the details are not described. In many studies, C1
is often omitted from CAG, and the two types C and O are often distinguished. These points
should also be mentioned.
The definition of gastric polyp examined in this study is unclear. Does it refer only to fundic
gland polyps, or does it also include hyperplastic polyps and adenomas? Since the background
gastric mucosa is expected to differ significantly depending on the definition, it is likely to have
a large impact on the relationship with lower GI findings, not just on age and gender.
The authors emphasized that correlations between endoscopic diseases especially  between
conditions like CAG and CPs However, as already mentioned, the underlying mechanism might
be partially associated with H. Pylori infection, and many studies suggested that H. Pylori
infection increased the risk of CPs or CRC. It is unfortunate that H. Pylori was not examined
in this study.
Please review this paper.
user
Title: Association between gastrointestinal lesions in individuals undergoing gastroscopy and
colonoscopy simultaneously: a retrospective, observational study
Version: 0 Date: 14 Sep 2024
Reviewer's report:
The authors have conducted a large-scale study of gastrointestinal lesions in individuals
undergoing gastroscopy and the relationship with colonoscopy.Although this is an interesting
study, it seems necessary to reconsider the disease definition and analysis methods.
The definition of atrophic gastritis in this study is unclear as to whether it was determined by
endoscopic or pathological diagnosis. The authors state that they used the Kimura-Takemoto
classification to diagnose CAG. However, the details are not described. In many studies, C1
is often omitted from CAG, and the two types C and O are often distinguished. These points
should also be mentioned.
The definition of gastric polyp examined in this study is unclear. Does it refer only to fundic
gland polyps, or does it also include hyperplastic polyps and adenomas? Since the background
gastric mucosa is expected to differ significantly depending on the definition, it is likely to have
a large impact on the relationship with lower GI findings, not just on age and gender.
The authors emphasized that correlations between endoscopic diseases especially  between
conditions like CAG and CPs However, as already mentioned, the underlying mechanism might
be partially associated with H. Pylori infection, and many studies suggested that H. Pylori
infection increased the risk of CPs or CRC. It is unfortunate that H. Pylori was not examined
in this study.
assistant