Title: Bile acid diarrhoea and metabolic changes after cholecystectomy: A prospective case-
control study
Version: 1 Date: 30 Jun 2024
Reviewer:  Subba Rao Kanchustambam
Reviewer's report:
While the study provides  well designed methodology and clear presentation of findings , some
explanations in the discussion could  provide clarity on the implications of FGF and PPAR
findings
1. The accuracy of results can be more meaningful if p-values are given along with confidence
intervals
2. The study concludes that FGF 19 levels increase post cholecystectomy but do not correlate
with BAD. Is it serum levels or gall bladder tissue levels?
3. The significant correlation between PPAR concentration( Where ? bowel or serum) and stool
consistency post operatively  is noted . Is this conclusion  overemphasising, as there is no
correlation between triglyceride level and stool consistency ?
Title: Bile acid diarrhoea and metabolic changes after cholecystectomy: A prospective case-
control study
Version: 1 Date: 30 Jun 2024
Reviewer:  Subba Rao Kanchustambam
Reviewer's report:
While the study provides  well designed methodology and clear presentation of findings , some
explanations in the discussion could  provide clarity on the implications of FGF and PPAR
findings
1. The accuracy of results can be more meaningful if p-values are given along with confidence
intervals
2. The study concludes that FGF 19 levels increase post cholecystectomy but do not correlate
with BAD. Is it serum levels or gall bladder tissue levels?
3. The significant correlation between PPAR concentration( Where ? bowel or serum) and stool
consistency post operatively  is noted . Is this conclusion  overemphasising, as there is no
correlation between triglyceride level and stool consistency ?
Please review this paper.
user
Title: Bile acid diarrhoea and metabolic changes after cholecystectomy: A prospective case-
control study
Version: 1 Date: 30 Jun 2024
Reviewer:  Subba Rao Kanchustambam
Reviewer's report:
While the study provides  well designed methodology and clear presentation of findings , some
explanations in the discussion could  provide clarity on the implications of FGF and PPAR
findings
1. The accuracy of results can be more meaningful if p-values are given along with confidence
intervals
2. The study concludes that FGF 19 levels increase post cholecystectomy but do not correlate
with BAD. Is it serum levels or gall bladder tissue levels?
3. The significant correlation between PPAR concentration( Where ? bowel or serum) and stool
consistency post operatively  is noted . Is this conclusion  overemphasising, as there is no
correlation between triglyceride level and stool consistency ?
assistant