Title: Pregnancy Outcomes in Women with Celiac Disease in Northeast Iran: A Regional
Retrospective Cohort Study
Version: 4 Date: 21 May 2024
Reviewer's report:
I thank the authors for their effort to respond and revise their manuscript according to the
reviewers comments and feed back. Unfortunately, the main concerns have not been enough
clarified and still needs profound revisions.
The methods and statistical analysis section is unstructured and difficult to follow. There are
still major concerns regarding how the authors came to the numbers of cases and controls. For
example, the study population is described in several sections. And, in 522 women who were
married, did only close to 20% choose to become pregnant? And, how did the authors come up
with the 2,2254 pregnant women from the general population of 533,894 pregnant women, of
which they then chose controls.  It seems it is a highly selected cases and controls.
The concern of adjusting factors in the logistic regression models is not addressed, it is still
stated that analyses were adjusted but not for what factors.
The manuscript continues to be unstructured, and without enough scientific grounds and
comparison with other data in the Discussion.
There is an improvement in the language, but the manuscript would still need profound language
editing.
Title: Pregnancy Outcomes in Women with Celiac Disease in Northeast Iran: A Regional
Retrospective Cohort Study
Version: 4 Date: 21 May 2024
Reviewer's report:
I thank the authors for their effort to respond and revise their manuscript according to the
reviewers comments and feed back. Unfortunately, the main concerns have not been enough
clarified and still needs profound revisions.
The methods and statistical analysis section is unstructured and difficult to follow. There are
still major concerns regarding how the authors came to the numbers of cases and controls. For
example, the study population is described in several sections. And, in 522 women who were
married, did only close to 20% choose to become pregnant? And, how did the authors come up
with the 2,2254 pregnant women from the general population of 533,894 pregnant women, of
which they then chose controls.  It seems it is a highly selected cases and controls.
The concern of adjusting factors in the logistic regression models is not addressed, it is still
stated that analyses were adjusted but not for what factors.
The manuscript continues to be unstructured, and without enough scientific grounds and
comparison with other data in the Discussion.
There is an improvement in the language, but the manuscript would still need profound language
editing.
Please review this paper.
user
Title: Pregnancy Outcomes in Women with Celiac Disease in Northeast Iran: A Regional
Retrospective Cohort Study
Version: 4 Date: 21 May 2024
Reviewer's report:
I thank the authors for their effort to respond and revise their manuscript according to the
reviewers comments and feed back. Unfortunately, the main concerns have not been enough
clarified and still needs profound revisions.
The methods and statistical analysis section is unstructured and difficult to follow. There are
still major concerns regarding how the authors came to the numbers of cases and controls. For
example, the study population is described in several sections. And, in 522 women who were
married, did only close to 20% choose to become pregnant? And, how did the authors come up
with the 2,2254 pregnant women from the general population of 533,894 pregnant women, of
which they then chose controls.  It seems it is a highly selected cases and controls.
The concern of adjusting factors in the logistic regression models is not addressed, it is still
stated that analyses were adjusted but not for what factors.
The manuscript continues to be unstructured, and without enough scientific grounds and
comparison with other data in the Discussion.
There is an improvement in the language, but the manuscript would still need profound language
editing.
assistant