Reviewer's report
Title:Mucosal atrophy in collagenous colitis: A case report
Version: 1Date:18 January 2011
Reviewer: Junji Umeno
Reviewer's report:
Comments to the Author
Majores et al. presented a patient with collagenous colitis (CC) for more than 10
years who developed segmental mucosal atrophy in the ascending and
transverse colon. This case report is very interesting, however, it is hard to
recognize mucosal atrophy of the proximal colon as a complication of long
standing CC due to lack of adequate evidence.
Major Compulsory Revisions
1. The time course of the development of mucosal atrophy is unclear. The
authors should present the endoscopic images of the cecum and histological
images of the biopsy specimen in 1998 and 2003.
2. The authors reported that the pattern of mucosal atrophy is inversely related to
the pattern of subepithelial collagen deposition and speculated the influence of
additional luminal factors on the development of mucosal atrophy. As the authors
discussed, mucosal atrophy is deemed to develop by chance. The authors
should show the evidence of relation between mucosal atrophy and CC; for
example, association between the site of mucosal atrophy and histological grade
of inflammation infiltrate.
Minor Essential Revisions
1. Figure 1B shows only subepithelial part of the specimen and also does not
look like a vertically-cut specimen. The authors should present a low-magnified
image showing total mucosal layer.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Mucosal atrophy in collagenous colitis: A case report
Version: 1Date:18 January 2011
Reviewer: Junji Umeno
Reviewer's report:
Comments to the Author
Majores et al. presented a patient with collagenous colitis (CC) for more than 10
years who developed segmental mucosal atrophy in the ascending and
transverse colon. This case report is very interesting, however, it is hard to
recognize mucosal atrophy of the proximal colon as a complication of long
standing CC due to lack of adequate evidence.
Major Compulsory Revisions
1. The time course of the development of mucosal atrophy is unclear. The
authors should present the endoscopic images of the cecum and histological
images of the biopsy specimen in 1998 and 2003.
2. The authors reported that the pattern of mucosal atrophy is inversely related to
the pattern of subepithelial collagen deposition and speculated the influence of
additional luminal factors on the development of mucosal atrophy. As the authors
discussed, mucosal atrophy is deemed to develop by chance. The authors
should show the evidence of relation between mucosal atrophy and CC; for
example, association between the site of mucosal atrophy and histological grade
of inflammation infiltrate.
Minor Essential Revisions
1. Figure 1B shows only subepithelial part of the specimen and also does not
look like a vertically-cut specimen. The authors should present a low-magnified
image showing total mucosal layer.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
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Reviewer's report
Title:Mucosal atrophy in collagenous colitis: A case report
Version: 1Date:18 January 2011
Reviewer: Junji Umeno
Reviewer's report:
Comments to the Author
Majores et al. presented a patient with collagenous colitis (CC) for more than 10
years who developed segmental mucosal atrophy in the ascending and
transverse colon. This case report is very interesting, however, it is hard to
recognize mucosal atrophy of the proximal colon as a complication of long
standing CC due to lack of adequate evidence.
Major Compulsory Revisions
1. The time course of the development of mucosal atrophy is unclear. The
authors should present the endoscopic images of the cecum and histological
images of the biopsy specimen in 1998 and 2003.
2. The authors reported that the pattern of mucosal atrophy is inversely related to
the pattern of subepithelial collagen deposition and speculated the influence of
additional luminal factors on the development of mucosal atrophy. As the authors
discussed, mucosal atrophy is deemed to develop by chance. The authors
should show the evidence of relation between mucosal atrophy and CC; for
example, association between the site of mucosal atrophy and histological grade
of inflammation infiltrate.
Minor Essential Revisions
1. Figure 1B shows only subepithelial part of the specimen and also does not
look like a vertically-cut specimen. The authors should present a low-magnified
image showing total mucosal layer.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant