Reviewer's report
Title:Leiomyosarcoma of sigmoid colon with multiple liver metastases and
gastric cancer: case report
Version: 1Date:7 May 2012
Reviewer: Thomas Resch
Reviewer's report:
Conclusions: “An immunohistochemical analysis is essential for a definitive
diagnosis of LMS, which is regularly negative for c-kit and CD34 and quite
positive for smooth muscle markers such as actin, desmin and h-caldesmon.”
Vimentin is another SMC marker with relevance for the diagnosis of LMS.
Furthermore, none of these SMC markers are specific for smooth muscle cell
differentiation. This should be mentioned in the text.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Leiomyosarcoma of sigmoid colon with multiple liver metastases and
gastric cancer: case report
Version: 1Date:7 May 2012
Reviewer: Thomas Resch
Reviewer's report:
Conclusions: “An immunohistochemical analysis is essential for a definitive
diagnosis of LMS, which is regularly negative for c-kit and CD34 and quite
positive for smooth muscle markers such as actin, desmin and h-caldesmon.”
Vimentin is another SMC marker with relevance for the diagnosis of LMS.
Furthermore, none of these SMC markers are specific for smooth muscle cell
differentiation. This should be mentioned in the text.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
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Reviewer's report
Title:Leiomyosarcoma of sigmoid colon with multiple liver metastases and
gastric cancer: case report
Version: 1Date:7 May 2012
Reviewer: Thomas Resch
Reviewer's report:
Conclusions: “An immunohistochemical analysis is essential for a definitive
diagnosis of LMS, which is regularly negative for c-kit and CD34 and quite
positive for smooth muscle markers such as actin, desmin and h-caldesmon.”
Vimentin is another SMC marker with relevance for the diagnosis of LMS.
Furthermore, none of these SMC markers are specific for smooth muscle cell
differentiation. This should be mentioned in the text.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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