Title: Fecal calprotectin is a useful biomarker for predicting the clinical outcome of granulocyte
and monocyte adsorptive apheresis in ulcerative colitis patients: a prospective observation study.
Version: 2 Date: 23 May 2021
Reviewer:  Naveen Sharma
Reviewer's report:
Overall I think this is an interesting study in that the group assesses the use of FC as a biomarker
to assess endoscopic and clinical remission in active UC treated with apheresis. Particularly as
this treatment causes a depletion in neutrophils in the circulation and colonic mucosa which
would be the main source of stool FC.
The study appears well designed with appropriate analysis and statistical methods. The findings
suggest FC could be a useful biomarker to predict early response to apheresis therapy and also
mucosal healing after successful clinical remission.
This is a small study and the authors recognise this and in itself would be best regarded as pilot
study requiring further larger studies.
Minor point: Line 156 the word Adacolumn is misspelt.
Title: Fecal calprotectin is a useful biomarker for predicting the clinical outcome of granulocyte
and monocyte adsorptive apheresis in ulcerative colitis patients: a prospective observation study.
Version: 2 Date: 23 May 2021
Reviewer:  Naveen Sharma
Reviewer's report:
Overall I think this is an interesting study in that the group assesses the use of FC as a biomarker
to assess endoscopic and clinical remission in active UC treated with apheresis. Particularly as
this treatment causes a depletion in neutrophils in the circulation and colonic mucosa which
would be the main source of stool FC.
The study appears well designed with appropriate analysis and statistical methods. The findings
suggest FC could be a useful biomarker to predict early response to apheresis therapy and also
mucosal healing after successful clinical remission.
This is a small study and the authors recognise this and in itself would be best regarded as pilot
study requiring further larger studies.
Minor point: Line 156 the word Adacolumn is misspelt.
Please review this paper.
user
Title: Fecal calprotectin is a useful biomarker for predicting the clinical outcome of granulocyte
and monocyte adsorptive apheresis in ulcerative colitis patients: a prospective observation study.
Version: 2 Date: 23 May 2021
Reviewer:  Naveen Sharma
Reviewer's report:
Overall I think this is an interesting study in that the group assesses the use of FC as a biomarker
to assess endoscopic and clinical remission in active UC treated with apheresis. Particularly as
this treatment causes a depletion in neutrophils in the circulation and colonic mucosa which
would be the main source of stool FC.
The study appears well designed with appropriate analysis and statistical methods. The findings
suggest FC could be a useful biomarker to predict early response to apheresis therapy and also
mucosal healing after successful clinical remission.
This is a small study and the authors recognise this and in itself would be best regarded as pilot
study requiring further larger studies.
Minor point: Line 156 the word Adacolumn is misspelt.
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