Title: Efficacy comparison of 7- and 14-day P-CAB based bismuth-containing quadruple
regimen with PPI based bismuth-containing quadruple regimen for Helicobacter pylori
infection: rationale and design of an open-label, multicenter, randomized controlled trial
Version: 0 Date: 30 Sep 2023
Reviewer's report:
1.
In P4, study design, line 7, “The PC-BMT regimens will consist of tegoprazan 50 mg BID,
bismuth subcitrate 300 mg QID, tetracycline 500 mg QID, metronidazole 500 mg TID, and
tetracycline 500 mg QID daily.” tetracycline 500mg QID was mentioned twice, which is an
unnecessary repeat, please revise this sentence.
2.
In P4, study design, line 7, “whereas the P-BMT regimen will consist of a standard dose of PPI
BID, bismuth subcitrate 300 mg QID, metronidazole 500 mg TID, and tetracycline 500 mg QID
daily.” PPI bid use is vital in H.pylori eradication regimen. Which kind of PPI regimen will be
used in this protocol should be mentioned clearly. Different PPI regimen might have different
dosage or different treatment efficacy, it is better to use the same regimen in this study. If the
authors have different opinion or idea, welcome to clarify this point.
Title: Efficacy comparison of 7- and 14-day P-CAB based bismuth-containing quadruple
regimen with PPI based bismuth-containing quadruple regimen for Helicobacter pylori
infection: rationale and design of an open-label, multicenter, randomized controlled trial
Version: 0 Date: 30 Sep 2023
Reviewer's report:
1.
In P4, study design, line 7, “The PC-BMT regimens will consist of tegoprazan 50 mg BID,
bismuth subcitrate 300 mg QID, tetracycline 500 mg QID, metronidazole 500 mg TID, and
tetracycline 500 mg QID daily.” tetracycline 500mg QID was mentioned twice, which is an
unnecessary repeat, please revise this sentence.
2.
In P4, study design, line 7, “whereas the P-BMT regimen will consist of a standard dose of PPI
BID, bismuth subcitrate 300 mg QID, metronidazole 500 mg TID, and tetracycline 500 mg QID
daily.” PPI bid use is vital in H.pylori eradication regimen. Which kind of PPI regimen will be
used in this protocol should be mentioned clearly. Different PPI regimen might have different
dosage or different treatment efficacy, it is better to use the same regimen in this study. If the
authors have different opinion or idea, welcome to clarify this point.
Please review this paper.
user
Title: Efficacy comparison of 7- and 14-day P-CAB based bismuth-containing quadruple
regimen with PPI based bismuth-containing quadruple regimen for Helicobacter pylori
infection: rationale and design of an open-label, multicenter, randomized controlled trial
Version: 0 Date: 30 Sep 2023
Reviewer's report:
1.
In P4, study design, line 7, “The PC-BMT regimens will consist of tegoprazan 50 mg BID,
bismuth subcitrate 300 mg QID, tetracycline 500 mg QID, metronidazole 500 mg TID, and
tetracycline 500 mg QID daily.” tetracycline 500mg QID was mentioned twice, which is an
unnecessary repeat, please revise this sentence.
2.
In P4, study design, line 7, “whereas the P-BMT regimen will consist of a standard dose of PPI
BID, bismuth subcitrate 300 mg QID, metronidazole 500 mg TID, and tetracycline 500 mg QID
daily.” PPI bid use is vital in H.pylori eradication regimen. Which kind of PPI regimen will be
used in this protocol should be mentioned clearly. Different PPI regimen might have different
dosage or different treatment efficacy, it is better to use the same regimen in this study. If the
authors have different opinion or idea, welcome to clarify this point.
assistant