Title: Three-to-Six Month Post-POEM Timed Barium Esophagram Can Predict Esophageal
Contents and May Stratify Aspiration Risk on Follow-up EGD
Version: 2 Date: 09 Mar 2025
Reviewer's report:
1. First, as a method, no details of the protocol for barium esophagography are given. It is unclear
if all contrast agents were administered to the same standard. Please clarify how many milliliters
of barium were administered, what the imaging interval was, and after how many minutes the
examination was completed.
The authors also mention tablet passage, but I could not find this statement in the methods section
either. Please clarify this as well.
2. I think it would be recommended to perform multivariate as well as univariate analysis.
Results considering other confounding factors (e.g., patient age, gender, type of achalasia, etc.)
would also be helpful.
3. I think that changes in IRP values should also be shown, since the authors use HRM to identify
the type of achalasia.
4. The authors mentioned that 23 (47.9%) post-POEM EGD were performed under tracheal
intubation, but considering the present results, how many patients did not require tracheal
intubation?
5. You should describe the methods and software used in the statistics.
Title: Three-to-Six Month Post-POEM Timed Barium Esophagram Can Predict Esophageal
Contents and May Stratify Aspiration Risk on Follow-up EGD
Version: 2 Date: 09 Mar 2025
Reviewer's report:
1. First, as a method, no details of the protocol for barium esophagography are given. It is unclear
if all contrast agents were administered to the same standard. Please clarify how many milliliters
of barium were administered, what the imaging interval was, and after how many minutes the
examination was completed.
The authors also mention tablet passage, but I could not find this statement in the methods section
either. Please clarify this as well.
2. I think it would be recommended to perform multivariate as well as univariate analysis.
Results considering other confounding factors (e.g., patient age, gender, type of achalasia, etc.)
would also be helpful.
3. I think that changes in IRP values should also be shown, since the authors use HRM to identify
the type of achalasia.
4. The authors mentioned that 23 (47.9%) post-POEM EGD were performed under tracheal
intubation, but considering the present results, how many patients did not require tracheal
intubation?
5. You should describe the methods and software used in the statistics.
Please review this paper.
user
Title: Three-to-Six Month Post-POEM Timed Barium Esophagram Can Predict Esophageal
Contents and May Stratify Aspiration Risk on Follow-up EGD
Version: 2 Date: 09 Mar 2025
Reviewer's report:
1. First, as a method, no details of the protocol for barium esophagography are given. It is unclear
if all contrast agents were administered to the same standard. Please clarify how many milliliters
of barium were administered, what the imaging interval was, and after how many minutes the
examination was completed.
The authors also mention tablet passage, but I could not find this statement in the methods section
either. Please clarify this as well.
2. I think it would be recommended to perform multivariate as well as univariate analysis.
Results considering other confounding factors (e.g., patient age, gender, type of achalasia, etc.)
would also be helpful.
3. I think that changes in IRP values should also be shown, since the authors use HRM to identify
the type of achalasia.
4. The authors mentioned that 23 (47.9%) post-POEM EGD were performed under tracheal
intubation, but considering the present results, how many patients did not require tracheal
intubation?
5. You should describe the methods and software used in the statistics.
assistant