Title: Serum Levels of Oxidative Stress, IL-8, and Pepsinogen I/II Ratio in Helicobacter pylori
and Gastric Cancer Patients: Potential Diagnostic Biomarkers
Version: 4 Date: 17 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Abbreviations should be explained on their first appearance in the text Numerical and p-
values for significant factors presented in the results should be provided  Space could be found in
the expense of background and terms repetition   Methods Protocol of tissue biopsies in patients
with gastritis and gastric cancer should be provided Was an endoscopy performed in controls?
Since they might had a gastritis and could have eradicated H. pylori after an antibiotic course
received in the past , in which way had authors secure that their patients  presented no gastritis?
Was UBT performed in every patient entered  the study?  Why had authors selected UBT instead
of histology for H. pylori status determination? In such a case it should be described in full
detail Should dyspepsia be a prerequisite to enter the study? Stage of gastric Ca belongs in th
results Comorbidities should be described in detail There is no reference about alcohol or opiois
use Have authors asked for them? Statistics Power of the study calculation belongs in statistics
Bacuse ANOVA have been used all three groups could be compared instead of pair comparisons
Results Apart from bar chart authors could include numerical values for Ile-8 determination
Title: Serum Levels of Oxidative Stress, IL-8, and Pepsinogen I/II Ratio in Helicobacter pylori
and Gastric Cancer Patients: Potential Diagnostic Biomarkers
Version: 4 Date: 17 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Abbreviations should be explained on their first appearance in the text Numerical and p-
values for significant factors presented in the results should be provided  Space could be found in
the expense of background and terms repetition   Methods Protocol of tissue biopsies in patients
with gastritis and gastric cancer should be provided Was an endoscopy performed in controls?
Since they might had a gastritis and could have eradicated H. pylori after an antibiotic course
received in the past , in which way had authors secure that their patients  presented no gastritis?
Was UBT performed in every patient entered  the study?  Why had authors selected UBT instead
of histology for H. pylori status determination? In such a case it should be described in full
detail Should dyspepsia be a prerequisite to enter the study? Stage of gastric Ca belongs in th
results Comorbidities should be described in detail There is no reference about alcohol or opiois
use Have authors asked for them? Statistics Power of the study calculation belongs in statistics
Bacuse ANOVA have been used all three groups could be compared instead of pair comparisons
Results Apart from bar chart authors could include numerical values for Ile-8 determination
Please review this paper.
user
Title: Serum Levels of Oxidative Stress, IL-8, and Pepsinogen I/II Ratio in Helicobacter pylori
and Gastric Cancer Patients: Potential Diagnostic Biomarkers
Version: 4 Date: 17 Nov 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Abstract Abbreviations should be explained on their first appearance in the text Numerical and p-
values for significant factors presented in the results should be provided  Space could be found in
the expense of background and terms repetition   Methods Protocol of tissue biopsies in patients
with gastritis and gastric cancer should be provided Was an endoscopy performed in controls?
Since they might had a gastritis and could have eradicated H. pylori after an antibiotic course
received in the past , in which way had authors secure that their patients  presented no gastritis?
Was UBT performed in every patient entered  the study?  Why had authors selected UBT instead
of histology for H. pylori status determination? In such a case it should be described in full
detail Should dyspepsia be a prerequisite to enter the study? Stage of gastric Ca belongs in th
results Comorbidities should be described in detail There is no reference about alcohol or opiois
use Have authors asked for them? Statistics Power of the study calculation belongs in statistics
Bacuse ANOVA have been used all three groups could be compared instead of pair comparisons
Results Apart from bar chart authors could include numerical values for Ile-8 determination
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