Reviewer's report
Title:Life-threatening hypersplenism due to idiopathic portal hypertension in
early childhood: Case report and review of the literature
Version: 3Date:31 May 2010
Reviewer: moritz M ziegler
Reviewer's report:
The quality of the manuscript is much improved and its "readability" is
satisfactory. The author's have satisfactorily addressed the critques of the
reviewers. The patient outcome result of the case report is excellent, but the
cause-effect relationship of the abnormal marker expression and proposed
pathophysiology of Idiopathic Portal Hypertension is still not without a degree of
speculation since causality could be a "secondary effect" as well. The abstract,
conclusions, tables and figures are all improved and should not need further
modification.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Life-threatening hypersplenism due to idiopathic portal hypertension in
early childhood: Case report and review of the literature
Version: 3Date:31 May 2010
Reviewer: moritz M ziegler
Reviewer's report:
The quality of the manuscript is much improved and its "readability" is
satisfactory. The author's have satisfactorily addressed the critques of the
reviewers. The patient outcome result of the case report is excellent, but the
cause-effect relationship of the abnormal marker expression and proposed
pathophysiology of Idiopathic Portal Hypertension is still not without a degree of
speculation since causality could be a "secondary effect" as well. The abstract,
conclusions, tables and figures are all improved and should not need further
modification.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Life-threatening hypersplenism due to idiopathic portal hypertension in
early childhood: Case report and review of the literature
Version: 3Date:31 May 2010
Reviewer: moritz M ziegler
Reviewer's report:
The quality of the manuscript is much improved and its "readability" is
satisfactory. The author's have satisfactorily addressed the critques of the
reviewers. The patient outcome result of the case report is excellent, but the
cause-effect relationship of the abnormal marker expression and proposed
pathophysiology of Idiopathic Portal Hypertension is still not without a degree of
speculation since causality could be a "secondary effect" as well. The abstract,
conclusions, tables and figures are all improved and should not need further
modification.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant