Reviewer's report
Title:Food allergy alters jejunal circular muscle contractility and induces local
inflammatory cytokine expression in a mouse model
Version: 1Date:23 November 2008
Reviewer: Hirotada Akiho
Reviewer's report:
Comments to Authors
The experiments are carefully performed and the manuscript has implications for
investigators in the fields of both motility and inflammation.
Minor comments
#1 Results
Page 11, cytokine expression
Do you have any data for cytokine expression in circular muscle alone?
If not, you should mention about how local Th2 cytokines affect the circular
muscle contractility in discussion. (e.g. Macrophage, Zhao A et al.
Gastroenterology 2008, 5-HT, Motomura Y et al. Gut 2008)
#2 Page 11, smooth muscle contractility
It is worthwhile to look at the ileal smooth muscle contractility.
#3 Page 22
Table 1
You should delete the results of 1:20 dilution.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Food allergy alters jejunal circular muscle contractility and induces local
inflammatory cytokine expression in a mouse model
Version: 1Date:23 November 2008
Reviewer: Hirotada Akiho
Reviewer's report:
Comments to Authors
The experiments are carefully performed and the manuscript has implications for
investigators in the fields of both motility and inflammation.
Minor comments
#1 Results
Page 11, cytokine expression
Do you have any data for cytokine expression in circular muscle alone?
If not, you should mention about how local Th2 cytokines affect the circular
muscle contractility in discussion. (e.g. Macrophage, Zhao A et al.
Gastroenterology 2008, 5-HT, Motomura Y et al. Gut 2008)
#2 Page 11, smooth muscle contractility
It is worthwhile to look at the ileal smooth muscle contractility.
#3 Page 22
Table 1
You should delete the results of 1:20 dilution.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Food allergy alters jejunal circular muscle contractility and induces local
inflammatory cytokine expression in a mouse model
Version: 1Date:23 November 2008
Reviewer: Hirotada Akiho
Reviewer's report:
Comments to Authors
The experiments are carefully performed and the manuscript has implications for
investigators in the fields of both motility and inflammation.
Minor comments
#1 Results
Page 11, cytokine expression
Do you have any data for cytokine expression in circular muscle alone?
If not, you should mention about how local Th2 cytokines affect the circular
muscle contractility in discussion. (e.g. Macrophage, Zhao A et al.
Gastroenterology 2008, 5-HT, Motomura Y et al. Gut 2008)
#2 Page 11, smooth muscle contractility
It is worthwhile to look at the ileal smooth muscle contractility.
#3 Page 22
Table 1
You should delete the results of 1:20 dilution.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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