Title: Iceball Growth 3D Simulation Model Based on Finite Element Method for Hepatic
Cryoablation Planning
Version: 2 Date: 25 Feb 2025
Reviewer's report:
Still, the model is not correct and the figure is not updated with modification of vessels
introduced.
Let us consider these two equations:
#C #T/#t=#·K#T+#_b #_b c_b (T_b-T)+Q_hs+Q_m
#C #T/#t=#·K#T+Q_hs-#_b#_b u_b·#T+Q_m
The difference between these two equations are on #_b #_b c_b (T_b-T) and #_b#_b u_b·#T
The first equation is a Netwonian heat exchange between T and T_b whereas the second equation
has a convective heat transfer term.
The first equation is an approximate model of the second equation. Researchers approximate
#_b#_b u_b·#T by #_b #_b c_b (T_b-T) because solving  u_b is time consuming.
The first equation is the Standard Pennes Bioheat equation (1948)
The second equation is the Chen & Holmes model (1980) where microvascular contributions
in tissue heat transfer are provided.
Similarly, there are other models such as distributed convection by Wuff (1974), and Kotte
model (1999) on hybrid bioheat equation. Two-phase models for tissue and blood (1992) are
also available.
The author is using either the microvascular model or the Wuff model. Therefore, the model
section has to be re-organized as follows:
Option (1)
Move the first equation after line number 233. Keep the second equation in line number 240.
State that the first equation is modified as the second equation.
Option(2)
No need to specify the first equation, you can specify only the second equation directly at line
241.
In both cases, the proper citation is required.
The citation for the Arrhenius model is missing. The reference [23] can be replaced by the
reference of
https://www.sciencedirect.com/science/article/pii/S0017931018348786?
pes=vor&utm_source=tfo&getft_integrator=tfo
Citation [25] states that the Machine learning model for the equation has no connection to the
vascular system. Please provide the proper reference for it.
The same is applicable for the 261 to 264.
Regarding the simulation and figures:
The author claims that "To model the vascular structure adjacent to the tumor, a cylindrical tube
with a 3 mm diameter and  20mm away from and parallel to the cryoprobe was introduced into
the domain to simulate the hepatic artery with the velocity of blood flow of 44.3 cm/s, consistent
with measurements from human liver anatomy"
This is not visible in any of the figures. The previous submission figure and this figure look the
same. Please check this figure if it was wrongly uploaded.
Title: Iceball Growth 3D Simulation Model Based on Finite Element Method for Hepatic
Cryoablation Planning
Version: 2 Date: 25 Feb 2025
Reviewer's report:
Still, the model is not correct and the figure is not updated with modification of vessels
introduced.
Let us consider these two equations:
#C #T/#t=#·K#T+#_b #_b c_b (T_b-T)+Q_hs+Q_m
#C #T/#t=#·K#T+Q_hs-#_b#_b u_b·#T+Q_m
The difference between these two equations are on #_b #_b c_b (T_b-T) and #_b#_b u_b·#T
The first equation is a Netwonian heat exchange between T and T_b whereas the second equation
has a convective heat transfer term.
The first equation is an approximate model of the second equation. Researchers approximate
#_b#_b u_b·#T by #_b #_b c_b (T_b-T) because solving  u_b is time consuming.
The first equation is the Standard Pennes Bioheat equation (1948)
The second equation is the Chen & Holmes model (1980) where microvascular contributions
in tissue heat transfer are provided.
Similarly, there are other models such as distributed convection by Wuff (1974), and Kotte
model (1999) on hybrid bioheat equation. Two-phase models for tissue and blood (1992) are
also available.
The author is using either the microvascular model or the Wuff model. Therefore, the model
section has to be re-organized as follows:
Option (1)
Move the first equation after line number 233. Keep the second equation in line number 240.
State that the first equation is modified as the second equation.
Option(2)
No need to specify the first equation, you can specify only the second equation directly at line
241.
In both cases, the proper citation is required.
The citation for the Arrhenius model is missing. The reference [23] can be replaced by the
reference of
https://www.sciencedirect.com/science/article/pii/S0017931018348786?
pes=vor&utm_source=tfo&getft_integrator=tfo
Citation [25] states that the Machine learning model for the equation has no connection to the
vascular system. Please provide the proper reference for it.
The same is applicable for the 261 to 264.
Regarding the simulation and figures:
The author claims that "To model the vascular structure adjacent to the tumor, a cylindrical tube
with a 3 mm diameter and  20mm away from and parallel to the cryoprobe was introduced into
the domain to simulate the hepatic artery with the velocity of blood flow of 44.3 cm/s, consistent
with measurements from human liver anatomy"
This is not visible in any of the figures. The previous submission figure and this figure look the
same. Please check this figure if it was wrongly uploaded.
Please review this paper.
user
Title: Iceball Growth 3D Simulation Model Based on Finite Element Method for Hepatic
Cryoablation Planning
Version: 2 Date: 25 Feb 2025
Reviewer's report:
Still, the model is not correct and the figure is not updated with modification of vessels
introduced.
Let us consider these two equations:
#C #T/#t=#·K#T+#_b #_b c_b (T_b-T)+Q_hs+Q_m
#C #T/#t=#·K#T+Q_hs-#_b#_b u_b·#T+Q_m
The difference between these two equations are on #_b #_b c_b (T_b-T) and #_b#_b u_b·#T
The first equation is a Netwonian heat exchange between T and T_b whereas the second equation
has a convective heat transfer term.
The first equation is an approximate model of the second equation. Researchers approximate
#_b#_b u_b·#T by #_b #_b c_b (T_b-T) because solving  u_b is time consuming.
The first equation is the Standard Pennes Bioheat equation (1948)
The second equation is the Chen & Holmes model (1980) where microvascular contributions
in tissue heat transfer are provided.
Similarly, there are other models such as distributed convection by Wuff (1974), and Kotte
model (1999) on hybrid bioheat equation. Two-phase models for tissue and blood (1992) are
also available.
The author is using either the microvascular model or the Wuff model. Therefore, the model
section has to be re-organized as follows:
Option (1)
Move the first equation after line number 233. Keep the second equation in line number 240.
State that the first equation is modified as the second equation.
Option(2)
No need to specify the first equation, you can specify only the second equation directly at line
241.
In both cases, the proper citation is required.
The citation for the Arrhenius model is missing. The reference [23] can be replaced by the
reference of
https://www.sciencedirect.com/science/article/pii/S0017931018348786?
pes=vor&utm_source=tfo&getft_integrator=tfo
Citation [25] states that the Machine learning model for the equation has no connection to the
vascular system. Please provide the proper reference for it.
The same is applicable for the 261 to 264.
Regarding the simulation and figures:
The author claims that "To model the vascular structure adjacent to the tumor, a cylindrical tube
with a 3 mm diameter and  20mm away from and parallel to the cryoprobe was introduced into
the domain to simulate the hepatic artery with the velocity of blood flow of 44.3 cm/s, consistent
with measurements from human liver anatomy"
This is not visible in any of the figures. The previous submission figure and this figure look the
same. Please check this figure if it was wrongly uploaded.
assistant