Title: Lymph node ratio is a prognostic indicator for locally advanced gastric cancer after
neoadjuvant immunochemotherapy
Version: 4 Date: 18 Sep 2024
Reviewer:  Shunji Endo
Reviewer's report:
Thank you for the opportunity to review your article "Lymph node ratio is a prognostic indicator
for locally advanced gastric cancer after neoadjuvant immunochemotherapy".
Neoadjuvant immunochemotherapy is a hot topic at present, so I read your paper with great
interest.
I think it is a great paper, but I have a few comments.
1. Because ypN and LNR are strongly correlated, I think it is inappropriate to include both in
the multivariate analysis. Therefore, we cannot say that LNR is a better prognostic factor than
ypN in this study.
2. I don't quite understand the meaning of "The results show that LNR is an effective means
of identifying patients who do not achieve pCR with higher accuracy than other approaches" in
the Discussion section. If LNR is higher than 0.33, it of course means non-pCR, because pCR
means LNR = 0.
3. The texts in the figures are too small to read.
Title: Lymph node ratio is a prognostic indicator for locally advanced gastric cancer after
neoadjuvant immunochemotherapy
Version: 4 Date: 18 Sep 2024
Reviewer:  Shunji Endo
Reviewer's report:
Thank you for the opportunity to review your article "Lymph node ratio is a prognostic indicator
for locally advanced gastric cancer after neoadjuvant immunochemotherapy".
Neoadjuvant immunochemotherapy is a hot topic at present, so I read your paper with great
interest.
I think it is a great paper, but I have a few comments.
1. Because ypN and LNR are strongly correlated, I think it is inappropriate to include both in
the multivariate analysis. Therefore, we cannot say that LNR is a better prognostic factor than
ypN in this study.
2. I don't quite understand the meaning of "The results show that LNR is an effective means
of identifying patients who do not achieve pCR with higher accuracy than other approaches" in
the Discussion section. If LNR is higher than 0.33, it of course means non-pCR, because pCR
means LNR = 0.
3. The texts in the figures are too small to read.
Please review this paper.
user
Title: Lymph node ratio is a prognostic indicator for locally advanced gastric cancer after
neoadjuvant immunochemotherapy
Version: 4 Date: 18 Sep 2024
Reviewer:  Shunji Endo
Reviewer's report:
Thank you for the opportunity to review your article "Lymph node ratio is a prognostic indicator
for locally advanced gastric cancer after neoadjuvant immunochemotherapy".
Neoadjuvant immunochemotherapy is a hot topic at present, so I read your paper with great
interest.
I think it is a great paper, but I have a few comments.
1. Because ypN and LNR are strongly correlated, I think it is inappropriate to include both in
the multivariate analysis. Therefore, we cannot say that LNR is a better prognostic factor than
ypN in this study.
2. I don't quite understand the meaning of "The results show that LNR is an effective means
of identifying patients who do not achieve pCR with higher accuracy than other approaches" in
the Discussion section. If LNR is higher than 0.33, it of course means non-pCR, because pCR
means LNR = 0.
3. The texts in the figures are too small to read.
assistant