Reviewer's report
Title:Inverse association between gastroesophageal reflux and blood pressure:
results of a large community based study.
Version: 1Date:1 November 2007
Reviewer: Michael Mendall
Reviewer's report:
The study is interesting but I have a number of concerns:
The biological plausibility for the hypothesis is relatively weak.
Of most concern is the fact that in the whole population including subjects with
hypertension there are no relationships or if anything relationships in the other
direction. The most honest analysis is to include all the subjects adjusting for
treatment with anti-hypertensive medication.
Only one of the four possible analyses(systolic BP v regurg and heartburn,
diastolic BP v regurgitation and heartburn) is statistically significant.
There is no evidence of any dose response ie increasing severity of reflux and
heart burn being associated with a graded response of BP.
Why were not all of the subjects available from the community study included?
Reviewer's report
Title:Inverse association between gastroesophageal reflux and blood pressure:
results of a large community based study.
Version: 1Date:1 November 2007
Reviewer: Michael Mendall
Reviewer's report:
The study is interesting but I have a number of concerns:
The biological plausibility for the hypothesis is relatively weak.
Of most concern is the fact that in the whole population including subjects with
hypertension there are no relationships or if anything relationships in the other
direction. The most honest analysis is to include all the subjects adjusting for
treatment with anti-hypertensive medication.
Only one of the four possible analyses(systolic BP v regurg and heartburn,
diastolic BP v regurgitation and heartburn) is statistically significant.
There is no evidence of any dose response ie increasing severity of reflux and
heart burn being associated with a graded response of BP.
Why were not all of the subjects available from the community study included?
Please review this paper.
user
Reviewer's report
Title:Inverse association between gastroesophageal reflux and blood pressure:
results of a large community based study.
Version: 1Date:1 November 2007
Reviewer: Michael Mendall
Reviewer's report:
The study is interesting but I have a number of concerns:
The biological plausibility for the hypothesis is relatively weak.
Of most concern is the fact that in the whole population including subjects with
hypertension there are no relationships or if anything relationships in the other
direction. The most honest analysis is to include all the subjects adjusting for
treatment with anti-hypertensive medication.
Only one of the four possible analyses(systolic BP v regurg and heartburn,
diastolic BP v regurgitation and heartburn) is statistically significant.
There is no evidence of any dose response ie increasing severity of reflux and
heart burn being associated with a graded response of BP.
Why were not all of the subjects available from the community study included?
assistant