Title: Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver
disease: A bidirectional Mendelian randomization study
Version: 2 Date: 18 Jul 2024
Reviewer's report:
The authors attempted to evaluate the association between NAFLD and psychiatric disorders.
There are some concerns that need to be addressed;
1. We need to focus on NAFLD patients as organic diseases, and we need to consider more
confounding factors to improve the robustness of the results. Multivariate MR can be used to
address this issue.
2. page 13 "Genes that predict NAFLD on neuropsychiatric disorders", what does this mean? I
recommended that a professional language editing agency handle the whole text.
3. I noticed that the abstract introduced reverse MR, which I did not find in the results section.
Reverse MR can greatly resolve the direction of causal association.
4. The discussion should provide a detailed discussion of positive/interesting results and analysis
of potential mechanisms.
Title: Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver
disease: A bidirectional Mendelian randomization study
Version: 2 Date: 18 Jul 2024
Reviewer's report:
The authors attempted to evaluate the association between NAFLD and psychiatric disorders.
There are some concerns that need to be addressed;
1. We need to focus on NAFLD patients as organic diseases, and we need to consider more
confounding factors to improve the robustness of the results. Multivariate MR can be used to
address this issue.
2. page 13 "Genes that predict NAFLD on neuropsychiatric disorders", what does this mean? I
recommended that a professional language editing agency handle the whole text.
3. I noticed that the abstract introduced reverse MR, which I did not find in the results section.
Reverse MR can greatly resolve the direction of causal association.
4. The discussion should provide a detailed discussion of positive/interesting results and analysis
of potential mechanisms.
Please review this paper.
user
Title: Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver
disease: A bidirectional Mendelian randomization study
Version: 2 Date: 18 Jul 2024
Reviewer's report:
The authors attempted to evaluate the association between NAFLD and psychiatric disorders.
There are some concerns that need to be addressed;
1. We need to focus on NAFLD patients as organic diseases, and we need to consider more
confounding factors to improve the robustness of the results. Multivariate MR can be used to
address this issue.
2. page 13 "Genes that predict NAFLD on neuropsychiatric disorders", what does this mean? I
recommended that a professional language editing agency handle the whole text.
3. I noticed that the abstract introduced reverse MR, which I did not find in the results section.
Reverse MR can greatly resolve the direction of causal association.
4. The discussion should provide a detailed discussion of positive/interesting results and analysis
of potential mechanisms.
assistant