Title: Prevalence of Autoimmune Pancreatitis in Pancreatic Resection for Suspected
Malignancy: A Systematic Review and Meta-analysis
Version: 3 Date: 09 Nov 2023
Reviewer's report:
I read the manuscript by Karamya et al. Prevalence of Autoimmune Pancreatitis in Pancreatic
Resection for Suspected Malignancy: A Scoping Review.
The authors collected data form 10 reports about patients that underwent pancreatic resection due
to suspicion of malignancy with some of those cases resulting in a benign process specifically
autoimmune pancreatitis.
This is an interesting and challenging topic however several issues should be addressed before
considering ir for publication.
1. English grammar needs to be revised.
2. Currently, the manuscript only reports on the prevalence of AIP 1 and 2. It would be useful to
provide some information (if available) on what was the diagnostic approach of the cases before
indicating surgery. Some places recommend immediate resection if a pancreatic mass seems
resectable without any further investigation. Such practices may affect the estimated prevalence
of benign disease undergoing surgery.
3. Reporting only AIP prevalence seems an opportunity may be wasted. Authors should try to
extract as much possible data and try to evaluate what clinical, serum and imaging characteristics
could increase the suspicion for either a bening or malignant mass. Other reports such as the
following should be considered and added to the results and discussion:
Chari ST, Takahashi N, Levy MJ, Smyrk TC, Clain JE, Pearson RK, et al: A diagnostic strat-
egy to distinguish autoimmune pancreatitis from pancreatic cancer. Clin Gastroenterol Hepatol
2009;7:1097–1103.
Yadav AK, Sharma R, Kandasamy D, Prad- han RK, Garg PK, Bhalla AS, et al: Perfusion CT
- can it resolve the pancreatic carcinoma versus mass forming chronic pancreatitis conundrum?
Pancreatology 2006; 16: 979
Zaheer A, Singh VK, Akshintala VS, Kawa- moto S, Tsai SD, Gage KL, et al: Differentiat-
ing autoimmune pancreatitis from pancreatic adenocarcinoma using dual-phase computed
tomography . J Comput Assist Tomogr 2014; 38:146–152.
Peláez-Luna M, Medina-Campos C, Uscanga-Domínuez L, Hernandez-Calleros J, Chan-
Nuñez C, Negrete E, Angeles A. A Nondilated Main Pancreatic Duct Predicts Type 2
Autoimmune Pancreatitis: Comparative Study of Resected Pancreatic Head Masses. Digestion.
2020;101(2):137-143.
4. Discussion should be revised accordingly to the potential modifications on content.
Title: Prevalence of Autoimmune Pancreatitis in Pancreatic Resection for Suspected
Malignancy: A Systematic Review and Meta-analysis
Version: 3 Date: 09 Nov 2023
Reviewer's report:
I read the manuscript by Karamya et al. Prevalence of Autoimmune Pancreatitis in Pancreatic
Resection for Suspected Malignancy: A Scoping Review.
The authors collected data form 10 reports about patients that underwent pancreatic resection due
to suspicion of malignancy with some of those cases resulting in a benign process specifically
autoimmune pancreatitis.
This is an interesting and challenging topic however several issues should be addressed before
considering ir for publication.
1. English grammar needs to be revised.
2. Currently, the manuscript only reports on the prevalence of AIP 1 and 2. It would be useful to
provide some information (if available) on what was the diagnostic approach of the cases before
indicating surgery. Some places recommend immediate resection if a pancreatic mass seems
resectable without any further investigation. Such practices may affect the estimated prevalence
of benign disease undergoing surgery.
3. Reporting only AIP prevalence seems an opportunity may be wasted. Authors should try to
extract as much possible data and try to evaluate what clinical, serum and imaging characteristics
could increase the suspicion for either a bening or malignant mass. Other reports such as the
following should be considered and added to the results and discussion:
Chari ST, Takahashi N, Levy MJ, Smyrk TC, Clain JE, Pearson RK, et al: A diagnostic strat-
egy to distinguish autoimmune pancreatitis from pancreatic cancer. Clin Gastroenterol Hepatol
2009;7:1097–1103.
Yadav AK, Sharma R, Kandasamy D, Prad- han RK, Garg PK, Bhalla AS, et al: Perfusion CT
- can it resolve the pancreatic carcinoma versus mass forming chronic pancreatitis conundrum?
Pancreatology 2006; 16: 979
Zaheer A, Singh VK, Akshintala VS, Kawa- moto S, Tsai SD, Gage KL, et al: Differentiat-
ing autoimmune pancreatitis from pancreatic adenocarcinoma using dual-phase computed
tomography . J Comput Assist Tomogr 2014; 38:146–152.
Peláez-Luna M, Medina-Campos C, Uscanga-Domínuez L, Hernandez-Calleros J, Chan-
Nuñez C, Negrete E, Angeles A. A Nondilated Main Pancreatic Duct Predicts Type 2
Autoimmune Pancreatitis: Comparative Study of Resected Pancreatic Head Masses. Digestion.
2020;101(2):137-143.
4. Discussion should be revised accordingly to the potential modifications on content.
Please review this paper.
user
Title: Prevalence of Autoimmune Pancreatitis in Pancreatic Resection for Suspected
Malignancy: A Systematic Review and Meta-analysis
Version: 3 Date: 09 Nov 2023
Reviewer's report:
I read the manuscript by Karamya et al. Prevalence of Autoimmune Pancreatitis in Pancreatic
Resection for Suspected Malignancy: A Scoping Review.
The authors collected data form 10 reports about patients that underwent pancreatic resection due
to suspicion of malignancy with some of those cases resulting in a benign process specifically
autoimmune pancreatitis.
This is an interesting and challenging topic however several issues should be addressed before
considering ir for publication.
1. English grammar needs to be revised.
2. Currently, the manuscript only reports on the prevalence of AIP 1 and 2. It would be useful to
provide some information (if available) on what was the diagnostic approach of the cases before
indicating surgery. Some places recommend immediate resection if a pancreatic mass seems
resectable without any further investigation. Such practices may affect the estimated prevalence
of benign disease undergoing surgery.
3. Reporting only AIP prevalence seems an opportunity may be wasted. Authors should try to
extract as much possible data and try to evaluate what clinical, serum and imaging characteristics
could increase the suspicion for either a bening or malignant mass. Other reports such as the
following should be considered and added to the results and discussion:
Chari ST, Takahashi N, Levy MJ, Smyrk TC, Clain JE, Pearson RK, et al: A diagnostic strat-
egy to distinguish autoimmune pancreatitis from pancreatic cancer. Clin Gastroenterol Hepatol
2009;7:1097–1103.
Yadav AK, Sharma R, Kandasamy D, Prad- han RK, Garg PK, Bhalla AS, et al: Perfusion CT
- can it resolve the pancreatic carcinoma versus mass forming chronic pancreatitis conundrum?
Pancreatology 2006; 16: 979
Zaheer A, Singh VK, Akshintala VS, Kawa- moto S, Tsai SD, Gage KL, et al: Differentiat-
ing autoimmune pancreatitis from pancreatic adenocarcinoma using dual-phase computed
tomography . J Comput Assist Tomogr 2014; 38:146–152.
Peláez-Luna M, Medina-Campos C, Uscanga-Domínuez L, Hernandez-Calleros J, Chan-
Nuñez C, Negrete E, Angeles A. A Nondilated Main Pancreatic Duct Predicts Type 2
Autoimmune Pancreatitis: Comparative Study of Resected Pancreatic Head Masses. Digestion.
2020;101(2):137-143.
4. Discussion should be revised accordingly to the potential modifications on content.
assistant