Title: Clinical application and effectiveness analysis of modified Asia-Pacific colorectal cancer
screening score combined with fecal occult blood test for colorectal cancer screening in
asymptomatic population
Version: 0 Date: 24 Feb 2025
Reviewer's report:
1. Investigating the risk factors for LN metastasis in  patients with stage T1 CRC is a topic that
is not related to the parimary objetive of this study. I  recommend excluding this issue.
2. The AUC value of modified APCS score combined with FOBT is higher than that of modified
APCS score and FOBT alone, but the 95% CIs overlap. Can you statistically prove that there
is a difference?
Title: Clinical application and effectiveness analysis of modified Asia-Pacific colorectal cancer
screening score combined with fecal occult blood test for colorectal cancer screening in
asymptomatic population
Version: 0 Date: 24 Feb 2025
Reviewer's report:
1. Investigating the risk factors for LN metastasis in  patients with stage T1 CRC is a topic that
is not related to the parimary objetive of this study. I  recommend excluding this issue.
2. The AUC value of modified APCS score combined with FOBT is higher than that of modified
APCS score and FOBT alone, but the 95% CIs overlap. Can you statistically prove that there
is a difference?
Please review this paper.
user
Title: Clinical application and effectiveness analysis of modified Asia-Pacific colorectal cancer
screening score combined with fecal occult blood test for colorectal cancer screening in
asymptomatic population
Version: 0 Date: 24 Feb 2025
Reviewer's report:
1. Investigating the risk factors for LN metastasis in  patients with stage T1 CRC is a topic that
is not related to the parimary objetive of this study. I  recommend excluding this issue.
2. The AUC value of modified APCS score combined with FOBT is higher than that of modified
APCS score and FOBT alone, but the 95% CIs overlap. Can you statistically prove that there
is a difference?
assistant