Title: Diagnostic performance and transportability of fecal Helicobacter pylori antigen test in
Uganda
Version: 1 Date: 27 Sep 2022
Reviewer:  Seiji Shiota
Reviewer's report:
The authors examined the diagnostic performance of a qualitative stool antigen test (SAT) in
individuals with dyspepsia in rural Uganda. They found that the SAT is a robust diagnostic test
to improve the diagnosis of H. pylori infection in people with dyspepsia. However, there are
several concerns in this study.
Major points
1. In this study, the authors used fifty-nine tested positive for the stool antigen test. The number
of subjects is small to conclude.
2. In this study, PCR method using biopsy specimen from gastric spot was used as gold standard.
However, H. pylori can be negative in the severe atrophy. Therefore, other test such as urea
breath test (UBT) is necessary to conclude.
3. Overall, the findings in this study are not enough for the level of this journal.
Minor comments
1. This manuscript needs native English editing.
Title: Diagnostic performance and transportability of fecal Helicobacter pylori antigen test in
Uganda
Version: 1 Date: 27 Sep 2022
Reviewer:  Seiji Shiota
Reviewer's report:
The authors examined the diagnostic performance of a qualitative stool antigen test (SAT) in
individuals with dyspepsia in rural Uganda. They found that the SAT is a robust diagnostic test
to improve the diagnosis of H. pylori infection in people with dyspepsia. However, there are
several concerns in this study.
Major points
1. In this study, the authors used fifty-nine tested positive for the stool antigen test. The number
of subjects is small to conclude.
2. In this study, PCR method using biopsy specimen from gastric spot was used as gold standard.
However, H. pylori can be negative in the severe atrophy. Therefore, other test such as urea
breath test (UBT) is necessary to conclude.
3. Overall, the findings in this study are not enough for the level of this journal.
Minor comments
1. This manuscript needs native English editing.
Please review this paper.
user
Title: Diagnostic performance and transportability of fecal Helicobacter pylori antigen test in
Uganda
Version: 1 Date: 27 Sep 2022
Reviewer:  Seiji Shiota
Reviewer's report:
The authors examined the diagnostic performance of a qualitative stool antigen test (SAT) in
individuals with dyspepsia in rural Uganda. They found that the SAT is a robust diagnostic test
to improve the diagnosis of H. pylori infection in people with dyspepsia. However, there are
several concerns in this study.
Major points
1. In this study, the authors used fifty-nine tested positive for the stool antigen test. The number
of subjects is small to conclude.
2. In this study, PCR method using biopsy specimen from gastric spot was used as gold standard.
However, H. pylori can be negative in the severe atrophy. Therefore, other test such as urea
breath test (UBT) is necessary to conclude.
3. Overall, the findings in this study are not enough for the level of this journal.
Minor comments
1. This manuscript needs native English editing.
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