Reviewer's report
Title:GDNF protects enteric glia from apoptosis: Evidence for an autocrine loop
Version: 4Date:12 August 2011
Reviewer: Bindu Chandrasekharan
Reviewer's report:
The authors Steinkamp et al in their article ‘GDNF protects apoptosis in enteric
glia: Evidence for an autocrine loop’ aims to unravel the role of a neurotrophin
glial derived neurotrophic factor (GDNF) in the regulation of enteric glial
apoptosis.
The authors have now performed additional experiments and included the new
data in the manuscript. They have also revised the discussion as suggested.
However one of the comments raised (comment no.4) has not been pursued as
the authors feel that it is beyond the scope of their manuscript. Otherwise I feel
that they have addressed all my concerns and the manuscript can be accepted
for publication in the current revised form.
Discretionary revision
1. The authors may include the statement that other cytokines like IL-6, IL-1B
had no effects on apoptosis in the results section (where they mention effects of
TNF-IFY), currently this is included as a part of the discussion in the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:GDNF protects enteric glia from apoptosis: Evidence for an autocrine loop
Version: 4Date:12 August 2011
Reviewer: Bindu Chandrasekharan
Reviewer's report:
The authors Steinkamp et al in their article ‘GDNF protects apoptosis in enteric
glia: Evidence for an autocrine loop’ aims to unravel the role of a neurotrophin
glial derived neurotrophic factor (GDNF) in the regulation of enteric glial
apoptosis.
The authors have now performed additional experiments and included the new
data in the manuscript. They have also revised the discussion as suggested.
However one of the comments raised (comment no.4) has not been pursued as
the authors feel that it is beyond the scope of their manuscript. Otherwise I feel
that they have addressed all my concerns and the manuscript can be accepted
for publication in the current revised form.
Discretionary revision
1. The authors may include the statement that other cytokines like IL-6, IL-1B
had no effects on apoptosis in the results section (where they mention effects of
TNF-IFY), currently this is included as a part of the discussion in the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:GDNF protects enteric glia from apoptosis: Evidence for an autocrine loop
Version: 4Date:12 August 2011
Reviewer: Bindu Chandrasekharan
Reviewer's report:
The authors Steinkamp et al in their article ‘GDNF protects apoptosis in enteric
glia: Evidence for an autocrine loop’ aims to unravel the role of a neurotrophin
glial derived neurotrophic factor (GDNF) in the regulation of enteric glial
apoptosis.
The authors have now performed additional experiments and included the new
data in the manuscript. They have also revised the discussion as suggested.
However one of the comments raised (comment no.4) has not been pursued as
the authors feel that it is beyond the scope of their manuscript. Otherwise I feel
that they have addressed all my concerns and the manuscript can be accepted
for publication in the current revised form.
Discretionary revision
1. The authors may include the statement that other cytokines like IL-6, IL-1B
had no effects on apoptosis in the results section (where they mention effects of
TNF-IFY), currently this is included as a part of the discussion in the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant