Reviewer's report
Title:Influence of HRH2 promoter polymorphism on aberrant DNA methylation of
DAPK and CDH1 in the gastric epithelium
Version: 1Date:31 July 2012
Reviewer: Michiro Otaka
Reviewer's report:
Authors have investigated the relationship between HRH2 promoter
polymorphism and DNA methylation of DAPK and CDH1 in non-cancerous
gastric epithelium. They demonstrated differences in DNA methylation status
between gastric cancer patients and non-cancerous subjects. The study is well
designed and results are interesting.
Please discuss or show some data, if possible, before publication.
General
1) In both GC and non-GC subjects, are there any difference in use of gastric
acid suppressant such as PPI or H2RA?
2) Authors should describe about endoscopic findings in the subjects (gastric
ulcer and/or duodenal ulcers).
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Influence of HRH2 promoter polymorphism on aberrant DNA methylation of
DAPK and CDH1 in the gastric epithelium
Version: 1Date:31 July 2012
Reviewer: Michiro Otaka
Reviewer's report:
Authors have investigated the relationship between HRH2 promoter
polymorphism and DNA methylation of DAPK and CDH1 in non-cancerous
gastric epithelium. They demonstrated differences in DNA methylation status
between gastric cancer patients and non-cancerous subjects. The study is well
designed and results are interesting.
Please discuss or show some data, if possible, before publication.
General
1) In both GC and non-GC subjects, are there any difference in use of gastric
acid suppressant such as PPI or H2RA?
2) Authors should describe about endoscopic findings in the subjects (gastric
ulcer and/or duodenal ulcers).
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Influence of HRH2 promoter polymorphism on aberrant DNA methylation of
DAPK and CDH1 in the gastric epithelium
Version: 1Date:31 July 2012
Reviewer: Michiro Otaka
Reviewer's report:
Authors have investigated the relationship between HRH2 promoter
polymorphism and DNA methylation of DAPK and CDH1 in non-cancerous
gastric epithelium. They demonstrated differences in DNA methylation status
between gastric cancer patients and non-cancerous subjects. The study is well
designed and results are interesting.
Please discuss or show some data, if possible, before publication.
General
1) In both GC and non-GC subjects, are there any difference in use of gastric
acid suppressant such as PPI or H2RA?
2) Authors should describe about endoscopic findings in the subjects (gastric
ulcer and/or duodenal ulcers).
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant