Reviewer's report
Title:Chromosomal imbalances are uncommon in Chagasic megaesophagus
Version: 4Date:8 January 2010
Reviewer: Clara Isabel González
Reviewer's report:
The authors have answered my points sufficiently well to allow their manuscript
to be published.
Discretionary revisions:
a) The study analyzed tissues obtained from patients with diagnosis of chagasic
megaesophagus. However, the authors did not mention how the diagnosis was
established and confirmed.
OK. Include a sentence related to the diagnosis of Chagas Disease.
b) Highlight the data in the frequency of Chagas disease in Brazil and South
America and its appearance in non-endemic areas.
OK.
c) The number of cases in each category as gender, alcoholism and tabaquism is
too small to evaluate the risk factors. Mention the limitation of the low number of
samples.
OK.
d) Reduce the number of references to those which are essential.
OK. Check if all the references are correct, on page 11 the reference 69 is
mentioned, when the total is 53.
Minor essential revision:
a) In the current form, table 1 is very difficult to read and understand, review it.
Some abbreviations are not defined; an example is “T”.
OK.
b) Tables 2 and 3 are misconfigured, therefore, it is suggested to correct its
formatting in the revised manuscript.
OK.
c) Figure 1 F shows lower resolution compared to the other quadrants.
OK.
d) The resolution of figure 2 could be improved especially in quadrants C and D.
OK.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Chromosomal imbalances are uncommon in Chagasic megaesophagus
Version: 4Date:8 January 2010
Reviewer: Clara Isabel González
Reviewer's report:
The authors have answered my points sufficiently well to allow their manuscript
to be published.
Discretionary revisions:
a) The study analyzed tissues obtained from patients with diagnosis of chagasic
megaesophagus. However, the authors did not mention how the diagnosis was
established and confirmed.
OK. Include a sentence related to the diagnosis of Chagas Disease.
b) Highlight the data in the frequency of Chagas disease in Brazil and South
America and its appearance in non-endemic areas.
OK.
c) The number of cases in each category as gender, alcoholism and tabaquism is
too small to evaluate the risk factors. Mention the limitation of the low number of
samples.
OK.
d) Reduce the number of references to those which are essential.
OK. Check if all the references are correct, on page 11 the reference 69 is
mentioned, when the total is 53.
Minor essential revision:
a) In the current form, table 1 is very difficult to read and understand, review it.
Some abbreviations are not defined; an example is “T”.
OK.
b) Tables 2 and 3 are misconfigured, therefore, it is suggested to correct its
formatting in the revised manuscript.
OK.
c) Figure 1 F shows lower resolution compared to the other quadrants.
OK.
d) The resolution of figure 2 could be improved especially in quadrants C and D.
OK.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Chromosomal imbalances are uncommon in Chagasic megaesophagus
Version: 4Date:8 January 2010
Reviewer: Clara Isabel González
Reviewer's report:
The authors have answered my points sufficiently well to allow their manuscript
to be published.
Discretionary revisions:
a) The study analyzed tissues obtained from patients with diagnosis of chagasic
megaesophagus. However, the authors did not mention how the diagnosis was
established and confirmed.
OK. Include a sentence related to the diagnosis of Chagas Disease.
b) Highlight the data in the frequency of Chagas disease in Brazil and South
America and its appearance in non-endemic areas.
OK.
c) The number of cases in each category as gender, alcoholism and tabaquism is
too small to evaluate the risk factors. Mention the limitation of the low number of
samples.
OK.
d) Reduce the number of references to those which are essential.
OK. Check if all the references are correct, on page 11 the reference 69 is
mentioned, when the total is 53.
Minor essential revision:
a) In the current form, table 1 is very difficult to read and understand, review it.
Some abbreviations are not defined; an example is “T”.
OK.
b) Tables 2 and 3 are misconfigured, therefore, it is suggested to correct its
formatting in the revised manuscript.
OK.
c) Figure 1 F shows lower resolution compared to the other quadrants.
OK.
d) The resolution of figure 2 could be improved especially in quadrants C and D.
OK.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant