Title: Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease
Version: 3 Date: 09 Jun 2022
Reviewer's report:
It is a very interesting study about the mucosal cytokine’s gene transcription and the response
to biological therapy in IBD patients.
I suggest improving the description of the variables in table 1. For example: "Primary/secondary"
would be Primary/secondary non-response? "Mucosal TNF" would be Mucosal TNF gene
transcription?
It would be interesting to better describe the UC and CD groups that responded to the treatment,
especially which biologics they used.
An interesting comparison would be the comparison divided by disease (UC or CD) and by drug
(anti-TNF responder versus anti-TNF non-responder), for example. I understand that this type
of analysis may be limited by the low number of patients in the sample, but the results would be
interesting to evaluate the association between the expression of cytokines in the mucosa and
the response to a certain class of medication. Please include this observations in the discussion.
An idea for future studies.
Title: Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease
Version: 3 Date: 09 Jun 2022
Reviewer's report:
It is a very interesting study about the mucosal cytokine’s gene transcription and the response
to biological therapy in IBD patients.
I suggest improving the description of the variables in table 1. For example: "Primary/secondary"
would be Primary/secondary non-response? "Mucosal TNF" would be Mucosal TNF gene
transcription?
It would be interesting to better describe the UC and CD groups that responded to the treatment,
especially which biologics they used.
An interesting comparison would be the comparison divided by disease (UC or CD) and by drug
(anti-TNF responder versus anti-TNF non-responder), for example. I understand that this type
of analysis may be limited by the low number of patients in the sample, but the results would be
interesting to evaluate the association between the expression of cytokines in the mucosa and
the response to a certain class of medication. Please include this observations in the discussion.
An idea for future studies.
Please review this paper.
user
Title: Pharmacodynamic mechanisms behind a refractory state in inflammatory bowel disease
Version: 3 Date: 09 Jun 2022
Reviewer's report:
It is a very interesting study about the mucosal cytokine’s gene transcription and the response
to biological therapy in IBD patients.
I suggest improving the description of the variables in table 1. For example: "Primary/secondary"
would be Primary/secondary non-response? "Mucosal TNF" would be Mucosal TNF gene
transcription?
It would be interesting to better describe the UC and CD groups that responded to the treatment,
especially which biologics they used.
An interesting comparison would be the comparison divided by disease (UC or CD) and by drug
(anti-TNF responder versus anti-TNF non-responder), for example. I understand that this type
of analysis may be limited by the low number of patients in the sample, but the results would be
interesting to evaluate the association between the expression of cytokines in the mucosa and
the response to a certain class of medication. Please include this observations in the discussion.
An idea for future studies.
assistant