Title: Systemic immune-inflammation index within the first postoperative hour as a predictor of
severe postoperative complications in upper abdominal surgery: A retrospective single-center
study
Version: 1 Date: 18 Jul 2022
Reviewer's report:
The paper seems technically sound however, the claims are not fully supported by the data.
Please see the comments below.
Statistical analysis of the data is sound.
The primary outcome as the incidence of postoperative complications in a well-defined and
researched elective population does not seem novel.
What is novel is the exploration of the prognostic value of  SII in this patient population.
Table 4: I am having trouble understanding how an OR of 1.0  for SII is a significant predictor
of postoperative complications.
Table 6:
please indicate what the actual cut of value is
please indicate how many had SII # 754.6×109/L  and how many <754.6×109/L
Page 4 line 22: the word "with" is repeated twice
Page 5 line 15: "cholecystectomy in 117 patients, cholecystectomy in 10 patients" - is there a
difference in these patient groups? I think its suppose to be "liver resections"
Page 7 lines 24-26: Can you suggest a potential correlation when you prior to that conclude that
no significant difference was detected in this study?
Page 7 lines 28-33: Please elaborate why there is a need for yet another variable to predict PPC
when we have - as you write - lactate, CRP, age, etc already?
Page 7 line 38: "Finally, we did not detect SII level change over time during the follow-up
visits." Nowhere in the method section is it indicated a follow-up visit. This sentence comes up
out of the blue.
Page 8 Line 2: Please specify, is it the 1-h SII altogether or the cutoff value of SII.
Thank you.
Title: Systemic immune-inflammation index within the first postoperative hour as a predictor of
severe postoperative complications in upper abdominal surgery: A retrospective single-center
study
Version: 1 Date: 18 Jul 2022
Reviewer's report:
The paper seems technically sound however, the claims are not fully supported by the data.
Please see the comments below.
Statistical analysis of the data is sound.
The primary outcome as the incidence of postoperative complications in a well-defined and
researched elective population does not seem novel.
What is novel is the exploration of the prognostic value of  SII in this patient population.
Table 4: I am having trouble understanding how an OR of 1.0  for SII is a significant predictor
of postoperative complications.
Table 6:
please indicate what the actual cut of value is
please indicate how many had SII # 754.6×109/L  and how many <754.6×109/L
Page 4 line 22: the word "with" is repeated twice
Page 5 line 15: "cholecystectomy in 117 patients, cholecystectomy in 10 patients" - is there a
difference in these patient groups? I think its suppose to be "liver resections"
Page 7 lines 24-26: Can you suggest a potential correlation when you prior to that conclude that
no significant difference was detected in this study?
Page 7 lines 28-33: Please elaborate why there is a need for yet another variable to predict PPC
when we have - as you write - lactate, CRP, age, etc already?
Page 7 line 38: "Finally, we did not detect SII level change over time during the follow-up
visits." Nowhere in the method section is it indicated a follow-up visit. This sentence comes up
out of the blue.
Page 8 Line 2: Please specify, is it the 1-h SII altogether or the cutoff value of SII.
Thank you.
Please review this paper.
user
Title: Systemic immune-inflammation index within the first postoperative hour as a predictor of
severe postoperative complications in upper abdominal surgery: A retrospective single-center
study
Version: 1 Date: 18 Jul 2022
Reviewer's report:
The paper seems technically sound however, the claims are not fully supported by the data.
Please see the comments below.
Statistical analysis of the data is sound.
The primary outcome as the incidence of postoperative complications in a well-defined and
researched elective population does not seem novel.
What is novel is the exploration of the prognostic value of  SII in this patient population.
Table 4: I am having trouble understanding how an OR of 1.0  for SII is a significant predictor
of postoperative complications.
Table 6:
please indicate what the actual cut of value is
please indicate how many had SII # 754.6×109/L  and how many <754.6×109/L
Page 4 line 22: the word "with" is repeated twice
Page 5 line 15: "cholecystectomy in 117 patients, cholecystectomy in 10 patients" - is there a
difference in these patient groups? I think its suppose to be "liver resections"
Page 7 lines 24-26: Can you suggest a potential correlation when you prior to that conclude that
no significant difference was detected in this study?
Page 7 lines 28-33: Please elaborate why there is a need for yet another variable to predict PPC
when we have - as you write - lactate, CRP, age, etc already?
Page 7 line 38: "Finally, we did not detect SII level change over time during the follow-up
visits." Nowhere in the method section is it indicated a follow-up visit. This sentence comes up
out of the blue.
Page 8 Line 2: Please specify, is it the 1-h SII altogether or the cutoff value of SII.
Thank you.
assistant