Reviewer ’s report  
 
Title: Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn's  
disease  
 
Version: 0 Date: 03 Oct 2016  
 
Reviewer: Anne Muller  
 
Reviewer's report:  
 
In this work, Lahat and co -workers have examined the HP infection state of 56 Crohn's disease 
patients, of whom 6 were positive, had extensive gastro -duodenitis and were subjected to Hp 
eradication therapy. The therapy did not change the histopathology as assessed per capsule 
endoscopy. Notably, 50% of all study subjects exhibited gastro -duodenitis despite being selected 
for the quiescent state of their disease. The conclusion of the study is that gastro -duodenitis 
symptoms will not go awa y upon Hp eradication in Crohn's disease patients, and confirm the 
known phenomenon that Hp infection is rare in CD patients.  
 
 
 
The manuscript will need to undergo extensive editing for language and grammar before 
publication. Also, it would help to have mor e meaningful figures. It is unclear to the lay person 
what is to be seen in Figures 2 and 3. Please provide a detailed figure legend and some guidance 
in interpreting the images.  
 
 
 
 
Are the me thods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statisti cal review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensiv ely edited  
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gai n or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the fu ture?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content o f the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
  
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript  is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativ ecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn's  
disease  
 
Version: 0 Date: 03 Oct 2016  
 
Reviewer: Anne Muller  
 
Reviewer's report:  
 
In this work, Lahat and co -workers have examined the HP infection state of 56 Crohn's disease 
patients, of whom 6 were positive, had extensive gastro -duodenitis and were subjected to Hp 
eradication therapy. The therapy did not change the histopathology as assessed per capsule 
endoscopy. Notably, 50% of all study subjects exhibited gastro -duodenitis despite being selected 
for the quiescent state of their disease. The conclusion of the study is that gastro -duodenitis 
symptoms will not go awa y upon Hp eradication in Crohn's disease patients, and confirm the 
known phenomenon that Hp infection is rare in CD patients.  
 
 
 
The manuscript will need to undergo extensive editing for language and grammar before 
publication. Also, it would help to have mor e meaningful figures. It is unclear to the lay person 
what is to be seen in Figures 2 and 3. Please provide a detailed figure legend and some guidance 
in interpreting the images.  
 
 
 
 
Are the me thods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statisti cal review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensiv ely edited  
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gai n or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the fu ture?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content o f the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
  
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript  is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativ ecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Helicobacter pylori prevalence and clinical significance in patients with quiescent Crohn's  
disease  
 
Version: 0 Date: 03 Oct 2016  
 
Reviewer: Anne Muller  
 
Reviewer's report:  
 
In this work, Lahat and co -workers have examined the HP infection state of 56 Crohn's disease 
patients, of whom 6 were positive, had extensive gastro -duodenitis and were subjected to Hp 
eradication therapy. The therapy did not change the histopathology as assessed per capsule 
endoscopy. Notably, 50% of all study subjects exhibited gastro -duodenitis despite being selected 
for the quiescent state of their disease. The conclusion of the study is that gastro -duodenitis 
symptoms will not go awa y upon Hp eradication in Crohn's disease patients, and confirm the 
known phenomenon that Hp infection is rare in CD patients.  
 
 
 
The manuscript will need to undergo extensive editing for language and grammar before 
publication. Also, it would help to have mor e meaningful figures. It is unclear to the lay person 
what is to be seen in Figures 2 and 3. Please provide a detailed figure legend and some guidance 
in interpreting the images.  
 
 
 
 
Are the me thods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statisti cal review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensiv ely edited  
 
 
 
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gai n or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the fu ture?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content o f the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
  
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript  is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativ ecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant