Title: Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in
children
Version: 4 Date: 17 Nov 2021
Reviewer's report:
I have put detailed my comments to your manuscript, you should receive it from the editor
It is really great work but in the present form can be very misleading for somebody who has
no experience in WD.
This paper suggests that low level of ceruloplasmin, below 16mg% is very sensitive and specific.
However, nobody even having such results should put diagnosis of WD. Having long experience
with WD, have seen many mistakes, when diagnosis was too fast.
Complexity diagnosis should be discussed.  Even DNA analysis which has 4 points, in my
opinion should have support by other metabolic tests – also there are mistakes.  It should be
discussed that ceruloplasmin results only apply only to the method used in your lab.
I do not understand who is in the group asymptomatic WD?
Results should be presented in more clear way,  details in Supplementary materials if needed.
However, changes of ceruloplasmin according to age, sex, in other liver disease, according to
genotype are interesting.
Title: Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in
children
Version: 4 Date: 17 Nov 2021
Reviewer's report:
I have put detailed my comments to your manuscript, you should receive it from the editor
It is really great work but in the present form can be very misleading for somebody who has
no experience in WD.
This paper suggests that low level of ceruloplasmin, below 16mg% is very sensitive and specific.
However, nobody even having such results should put diagnosis of WD. Having long experience
with WD, have seen many mistakes, when diagnosis was too fast.
Complexity diagnosis should be discussed.  Even DNA analysis which has 4 points, in my
opinion should have support by other metabolic tests – also there are mistakes.  It should be
discussed that ceruloplasmin results only apply only to the method used in your lab.
I do not understand who is in the group asymptomatic WD?
Results should be presented in more clear way,  details in Supplementary materials if needed.
However, changes of ceruloplasmin according to age, sex, in other liver disease, according to
genotype are interesting.
Please review this paper.
user
Title: Assessment of the diagnostic value of serum ceruloplasmin for Wilson’s disease in
children
Version: 4 Date: 17 Nov 2021
Reviewer's report:
I have put detailed my comments to your manuscript, you should receive it from the editor
It is really great work but in the present form can be very misleading for somebody who has
no experience in WD.
This paper suggests that low level of ceruloplasmin, below 16mg% is very sensitive and specific.
However, nobody even having such results should put diagnosis of WD. Having long experience
with WD, have seen many mistakes, when diagnosis was too fast.
Complexity diagnosis should be discussed.  Even DNA analysis which has 4 points, in my
opinion should have support by other metabolic tests – also there are mistakes.  It should be
discussed that ceruloplasmin results only apply only to the method used in your lab.
I do not understand who is in the group asymptomatic WD?
Results should be presented in more clear way,  details in Supplementary materials if needed.
However, changes of ceruloplasmin according to age, sex, in other liver disease, according to
genotype are interesting.
assistant