Title: Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to
lymphocyte ratio in a sample of Chinese Han population
Version: 3 Date: 11 Jul 2022
Reviewer's report:
The authors reported the results of an observational study that aimed to examine the
the reference range of Gamma-glutamyl transpeptidase to platelet ratio (GPR) and gamma-
glutamyl transpeptidase to lymphocyte ratio (GLR) in the Chinese Han population in the
Chaoshan region in South China. By analyzing the data of healthy patients admitted to a hospital
in South China, the authors showed the referenced ranges of GPR and GLR in different sex
and age groups. Significant differences in GPR and GLR between different sex and age groups
were found.
There are some comments.
Comments:
1. Title: This study analyzed data of patients admitted to a hospital. Whether this sample
resembles the Chinese Han population is questionable. I would suggest revising the title.
An example would be “Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl
transpeptidase to lymphocyte ratio in a sample of Chinese Han population.”
2. Methods: “Healthy persons aged 20-79 years were reviewed-.” How was “healthy” defined?
How many patients were screened for eligibility? How many screened patients were noted to be
“healthy”? How many screened patients did not fulfill the “healthy” criteria and were excluded?
Please clarify these issues in more detail.
3. Methods: “The subjects with serious hepatic insufficiency were excluded-.” How was “hepatic
insufficiency” defined? Was it based on a doctor’s diagnosis in ICD codes or laboratory tests?
What were the ICD codes or laboratory tests? Please clarify in more detail.
4. Methods: “Platelet and lymphocyte counts were determined by the Coulter method. GGT
was determined by the rate method.” Please provide more details regarding the measurement
methods (for instance, the name and manufacturer of the machine and the quality control
measures (such as coefficients of variation)).
5. Results (Table 1): It is long known that GGT levels are affected by excessive weight, alcohol,
and drugs (even herbal supplements) intake. A presentation of body mass index (or body weight),
alcohol, and drugs (including herbal supplements) intake information in this table is suggested.
6. Results (Tables 2 and 3): GGT levels are sensitive to multiple factors (for instance, excessive
weight, alcohol, and drugs, among others) in addition to demographic factors. It is unclear how
the authors considered these factors when establishing the reference ranges of GPR and GLR,
as presented in these tables. A strategy would be to exclude those with obesity and those who
drank alcohol or took high-risk medications.
Title: Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to
lymphocyte ratio in a sample of Chinese Han population
Version: 3 Date: 11 Jul 2022
Reviewer's report:
The authors reported the results of an observational study that aimed to examine the
the reference range of Gamma-glutamyl transpeptidase to platelet ratio (GPR) and gamma-
glutamyl transpeptidase to lymphocyte ratio (GLR) in the Chinese Han population in the
Chaoshan region in South China. By analyzing the data of healthy patients admitted to a hospital
in South China, the authors showed the referenced ranges of GPR and GLR in different sex
and age groups. Significant differences in GPR and GLR between different sex and age groups
were found.
There are some comments.
Comments:
1. Title: This study analyzed data of patients admitted to a hospital. Whether this sample
resembles the Chinese Han population is questionable. I would suggest revising the title.
An example would be “Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl
transpeptidase to lymphocyte ratio in a sample of Chinese Han population.”
2. Methods: “Healthy persons aged 20-79 years were reviewed-.” How was “healthy” defined?
How many patients were screened for eligibility? How many screened patients were noted to be
“healthy”? How many screened patients did not fulfill the “healthy” criteria and were excluded?
Please clarify these issues in more detail.
3. Methods: “The subjects with serious hepatic insufficiency were excluded-.” How was “hepatic
insufficiency” defined? Was it based on a doctor’s diagnosis in ICD codes or laboratory tests?
What were the ICD codes or laboratory tests? Please clarify in more detail.
4. Methods: “Platelet and lymphocyte counts were determined by the Coulter method. GGT
was determined by the rate method.” Please provide more details regarding the measurement
methods (for instance, the name and manufacturer of the machine and the quality control
measures (such as coefficients of variation)).
5. Results (Table 1): It is long known that GGT levels are affected by excessive weight, alcohol,
and drugs (even herbal supplements) intake. A presentation of body mass index (or body weight),
alcohol, and drugs (including herbal supplements) intake information in this table is suggested.
6. Results (Tables 2 and 3): GGT levels are sensitive to multiple factors (for instance, excessive
weight, alcohol, and drugs, among others) in addition to demographic factors. It is unclear how
the authors considered these factors when establishing the reference ranges of GPR and GLR,
as presented in these tables. A strategy would be to exclude those with obesity and those who
drank alcohol or took high-risk medications.
Please review this paper.
user
Title: Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl transpeptidase to
lymphocyte ratio in a sample of Chinese Han population
Version: 3 Date: 11 Jul 2022
Reviewer's report:
The authors reported the results of an observational study that aimed to examine the
the reference range of Gamma-glutamyl transpeptidase to platelet ratio (GPR) and gamma-
glutamyl transpeptidase to lymphocyte ratio (GLR) in the Chinese Han population in the
Chaoshan region in South China. By analyzing the data of healthy patients admitted to a hospital
in South China, the authors showed the referenced ranges of GPR and GLR in different sex
and age groups. Significant differences in GPR and GLR between different sex and age groups
were found.
There are some comments.
Comments:
1. Title: This study analyzed data of patients admitted to a hospital. Whether this sample
resembles the Chinese Han population is questionable. I would suggest revising the title.
An example would be “Gamma-glutamyl transpeptidase to platelet and gamma-glutamyl
transpeptidase to lymphocyte ratio in a sample of Chinese Han population.”
2. Methods: “Healthy persons aged 20-79 years were reviewed-.” How was “healthy” defined?
How many patients were screened for eligibility? How many screened patients were noted to be
“healthy”? How many screened patients did not fulfill the “healthy” criteria and were excluded?
Please clarify these issues in more detail.
3. Methods: “The subjects with serious hepatic insufficiency were excluded-.” How was “hepatic
insufficiency” defined? Was it based on a doctor’s diagnosis in ICD codes or laboratory tests?
What were the ICD codes or laboratory tests? Please clarify in more detail.
4. Methods: “Platelet and lymphocyte counts were determined by the Coulter method. GGT
was determined by the rate method.” Please provide more details regarding the measurement
methods (for instance, the name and manufacturer of the machine and the quality control
measures (such as coefficients of variation)).
5. Results (Table 1): It is long known that GGT levels are affected by excessive weight, alcohol,
and drugs (even herbal supplements) intake. A presentation of body mass index (or body weight),
alcohol, and drugs (including herbal supplements) intake information in this table is suggested.
6. Results (Tables 2 and 3): GGT levels are sensitive to multiple factors (for instance, excessive
weight, alcohol, and drugs, among others) in addition to demographic factors. It is unclear how
the authors considered these factors when establishing the reference ranges of GPR and GLR,
as presented in these tables. A strategy would be to exclude those with obesity and those who
drank alcohol or took high-risk medications.
assistant