Reviewer’ s report
Title: A case report of gastric amyloidosis due to multiple myeloma mimicking gastric cancer
Version: 0Date: 16 May 2020
Reviewer's report:The authors described an interesting case of gastric amyloidosis due to multiple myeloma.
However, the English language need to be polished extensively. For example, what is "gastric
horn""in older people"... and numerous grammar mistakes. From the case presentation point ofview, I have some questions:1. "Biopsies were taken in gastric antrum demonstrated chronicsuperficial gastritis (mild) and esophagus biopsies demonstrated moderate to severe atypicalhyperplasiaof squamous epithelium." Then, please add the endoscopic picture of the esophageallesion where you did the biopsy.2."Gastric antrum biopsies demonstrated chronic superficialgastritis (mild) and biopsies of esophagus demonstrated moderate to severe atypicalhyperplasia ofsquamous epithelium. Gastric cancer was thus suspected." I didn't find the logic between the twosentences, why was gastric cancer suspected while biopsies in the stomach showed gastritis.3.Figure 1AB's quality wasn't very good and didn't add much information to the description how itwas mimicking a gastric cancer.4. Did you perform EUS on this patient? What was the EUSresult?5."previous studies ignored that there are many similarities between gastric amyloidosis andgastric cancer, such as clinical and endoscopic manifestation andeven the appearance of biopsyunder a microscope." please describe how microscopically similar between gastric amyloidosisand gastric cancer?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assessAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
Reviewer’ s report
Title: A case report of gastric amyloidosis due to multiple myeloma mimicking gastric cancer
Version: 0Date: 16 May 2020
Reviewer's report:The authors described an interesting case of gastric amyloidosis due to multiple myeloma.
However, the English language need to be polished extensively. For example, what is "gastric
horn""in older people"... and numerous grammar mistakes. From the case presentation point ofview, I have some questions:1. "Biopsies were taken in gastric antrum demonstrated chronicsuperficial gastritis (mild) and esophagus biopsies demonstrated moderate to severe atypicalhyperplasiaof squamous epithelium." Then, please add the endoscopic picture of the esophageallesion where you did the biopsy.2."Gastric antrum biopsies demonstrated chronic superficialgastritis (mild) and biopsies of esophagus demonstrated moderate to severe atypicalhyperplasia ofsquamous epithelium. Gastric cancer was thus suspected." I didn't find the logic between the twosentences, why was gastric cancer suspected while biopsies in the stomach showed gastritis.3.Figure 1AB's quality wasn't very good and didn't add much information to the description how itwas mimicking a gastric cancer.4. Did you perform EUS on this patient? What was the EUSresult?5."previous studies ignored that there are many similarities between gastric amyloidosis andgastric cancer, such as clinical and endoscopic manifestation andeven the appearance of biopsyunder a microscope." please describe how microscopically similar between gastric amyloidosisand gastric cancer?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assessAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
Please review this paper.
user
Reviewer’ s report
Title: A case report of gastric amyloidosis due to multiple myeloma mimicking gastric cancer
Version: 0Date: 16 May 2020
Reviewer's report:The authors described an interesting case of gastric amyloidosis due to multiple myeloma.
However, the English language need to be polished extensively. For example, what is "gastric
horn""in older people"... and numerous grammar mistakes. From the case presentation point ofview, I have some questions:1. "Biopsies were taken in gastric antrum demonstrated chronicsuperficial gastritis (mild) and esophagus biopsies demonstrated moderate to severe atypicalhyperplasiaof squamous epithelium." Then, please add the endoscopic picture of the esophageallesion where you did the biopsy.2."Gastric antrum biopsies demonstrated chronic superficialgastritis (mild) and biopsies of esophagus demonstrated moderate to severe atypicalhyperplasia ofsquamous epithelium. Gastric cancer was thus suspected." I didn't find the logic between the twosentences, why was gastric cancer suspected while biopsies in the stomach showed gastritis.3.Figure 1AB's quality wasn't very good and didn't add much information to the description how itwas mimicking a gastric cancer.4. Did you perform EUS on this patient? What was the EUSresult?5."previous studies ignored that there are many similarities between gastric amyloidosis andgastric cancer, such as clinical and endoscopic manifestation andeven the appearance of biopsyunder a microscope." please describe how microscopically similar between gastric amyloidosisand gastric cancer?
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assessAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Not suitable for publication unless extensively editedDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-script is accepted for publication. Any comments that I do not wish to be included in the publishedreport have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please do not publish my name with my report.
(default)
assistant