Reviewer's report
Title:Dietary L-Arginine Supplementation Reduces Methotrexate-Induced
Intestinal Mucosal Injury in Rat
Version: 3Date:8 February 2012
Reviewer: Moïse Coëffier
Reviewer's report:
'Dietary L-Arginine Supplementation Reduces Methotrexate-Induced Intestinal
Mucosal Injury in Rat'
Tal Koppelmann, Yulia Pollak, Jorge Mogilner, Jacob Bejar, Arnold G. Coran and
Igor Sukhotnik
BMC Gastroenterology
Research article
General comments:
I thank the authors for their responses and revision of the manuscript.
Minor Essential Revisions
1/ As arginine was provide arginine in drinking water, I think that water intake
should be provide in the text (even if water intake was similar in all groups).
2/ I understand that an additional group with an isonitrogenous supply would
complicate the experimental design. However, I think that this type of group is
necessary to conclude. It was previously reported that other amino acids like
glutamine, glycine or histidine have protective effects on intestinal mucosa during
chemotherapy or inflammatory conditions. Thus, in the present study, is it a
specific effect of arginine? The authors should thus discuss the limits of their
study.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Dietary L-Arginine Supplementation Reduces Methotrexate-Induced
Intestinal Mucosal Injury in Rat
Version: 3Date:8 February 2012
Reviewer: Moïse Coëffier
Reviewer's report:
'Dietary L-Arginine Supplementation Reduces Methotrexate-Induced Intestinal
Mucosal Injury in Rat'
Tal Koppelmann, Yulia Pollak, Jorge Mogilner, Jacob Bejar, Arnold G. Coran and
Igor Sukhotnik
BMC Gastroenterology
Research article
General comments:
I thank the authors for their responses and revision of the manuscript.
Minor Essential Revisions
1/ As arginine was provide arginine in drinking water, I think that water intake
should be provide in the text (even if water intake was similar in all groups).
2/ I understand that an additional group with an isonitrogenous supply would
complicate the experimental design. However, I think that this type of group is
necessary to conclude. It was previously reported that other amino acids like
glutamine, glycine or histidine have protective effects on intestinal mucosa during
chemotherapy or inflammatory conditions. Thus, in the present study, is it a
specific effect of arginine? The authors should thus discuss the limits of their
study.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Dietary L-Arginine Supplementation Reduces Methotrexate-Induced
Intestinal Mucosal Injury in Rat
Version: 3Date:8 February 2012
Reviewer: Moïse Coëffier
Reviewer's report:
'Dietary L-Arginine Supplementation Reduces Methotrexate-Induced Intestinal
Mucosal Injury in Rat'
Tal Koppelmann, Yulia Pollak, Jorge Mogilner, Jacob Bejar, Arnold G. Coran and
Igor Sukhotnik
BMC Gastroenterology
Research article
General comments:
I thank the authors for their responses and revision of the manuscript.
Minor Essential Revisions
1/ As arginine was provide arginine in drinking water, I think that water intake
should be provide in the text (even if water intake was similar in all groups).
2/ I understand that an additional group with an isonitrogenous supply would
complicate the experimental design. However, I think that this type of group is
necessary to conclude. It was previously reported that other amino acids like
glutamine, glycine or histidine have protective effects on intestinal mucosa during
chemotherapy or inflammatory conditions. Thus, in the present study, is it a
specific effect of arginine? The authors should thus discuss the limits of their
study.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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