Title: Circulatory Resistin Levels in Inflammatory Bowel Disease: A Systematic Review and
Meta-Analysis
Version: 0 Date: 27 Jan 2024
Reviewer's report:
The article was well written and the statistics is reliable. I don't have major comments.
My only concern is about the high heterogeneity observed in all the analyses. Meta-regression
doesn't seem able to explore properly the sources of heterogeneity so the the authors should do
more efforts to assess this issue.
The authors could also try to run a ROC analysis to find the best cut-off value to discriminate
between positive and negative outcomes in IBD patients.
Discriminative ability based on an AUC curve 0.66 doesnt seem very high..........does this value
have a clinical meaning?
Title: Circulatory Resistin Levels in Inflammatory Bowel Disease: A Systematic Review and
Meta-Analysis
Version: 0 Date: 27 Jan 2024
Reviewer's report:
The article was well written and the statistics is reliable. I don't have major comments.
My only concern is about the high heterogeneity observed in all the analyses. Meta-regression
doesn't seem able to explore properly the sources of heterogeneity so the the authors should do
more efforts to assess this issue.
The authors could also try to run a ROC analysis to find the best cut-off value to discriminate
between positive and negative outcomes in IBD patients.
Discriminative ability based on an AUC curve 0.66 doesnt seem very high..........does this value
have a clinical meaning?
Please review this paper.
user
Title: Circulatory Resistin Levels in Inflammatory Bowel Disease: A Systematic Review and
Meta-Analysis
Version: 0 Date: 27 Jan 2024
Reviewer's report:
The article was well written and the statistics is reliable. I don't have major comments.
My only concern is about the high heterogeneity observed in all the analyses. Meta-regression
doesn't seem able to explore properly the sources of heterogeneity so the the authors should do
more efforts to assess this issue.
The authors could also try to run a ROC analysis to find the best cut-off value to discriminate
between positive and negative outcomes in IBD patients.
Discriminative ability based on an AUC curve 0.66 doesnt seem very high..........does this value
have a clinical meaning?
assistant