Title: Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections
Version: 0 Date: 13 Aug 2021
Reviewer's report:
I have several comments:
1. Please provide one section about probiotic supplementation effect on gut microbiome
during H pylori therapy and include more ref about this issue  e.g. Helicobacter 2016
Dec;21(6):493-503. Microb Pathog. 2017 Aug;109:156-161. Eur J Clin Microbiol Infect Dis.
2020 Jul;39(7):1365-1372.
2.Table 4: Please provide P value or statistical significance in each study. And I don't know if
the following study "Iran J Pediatr. 2013 Feb; 23(1): 79–84." was listed in Table 4
3. Table 5:Please revise the title :"Summary of current meta-analysis on the efficacy of probiotics
in cure of H. pylori infection" The listing study was not meta analysis and may add the term
"adult population "
4. Please re-write abstract. The following sentence "Helicobacter pylori (H. pylori) is one of
the most common causes of bacterial infections worldwide, mostly colonized in the human
stomach during childhood. Chronic infection with this bacterium increases the risk of developing
severe complications such as peptic ulcer and gastric adenocarcinoma. Unfortunately, none of
the available treatment regimens can completely eradicate this pathogen. Factors such as acidic
stomach conditions, trapping of antibiotics in the gastric mucosa, side effects of antibiotics,
dormancy phenomenon, and antibiotic resistance all contribute in reducing the rate of infection
eradication. In recent decades, probiotic therapy has been considered as one of the most desirable
ways to treat the infection of this bacterium."   should be deleted. And please add more concise
and important information focus on probiotic effect on H.P therapy.
Title: Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections
Version: 0 Date: 13 Aug 2021
Reviewer's report:
I have several comments:
1. Please provide one section about probiotic supplementation effect on gut microbiome
during H pylori therapy and include more ref about this issue  e.g. Helicobacter 2016
Dec;21(6):493-503. Microb Pathog. 2017 Aug;109:156-161. Eur J Clin Microbiol Infect Dis.
2020 Jul;39(7):1365-1372.
2.Table 4: Please provide P value or statistical significance in each study. And I don't know if
the following study "Iran J Pediatr. 2013 Feb; 23(1): 79–84." was listed in Table 4
3. Table 5:Please revise the title :"Summary of current meta-analysis on the efficacy of probiotics
in cure of H. pylori infection" The listing study was not meta analysis and may add the term
"adult population "
4. Please re-write abstract. The following sentence "Helicobacter pylori (H. pylori) is one of
the most common causes of bacterial infections worldwide, mostly colonized in the human
stomach during childhood. Chronic infection with this bacterium increases the risk of developing
severe complications such as peptic ulcer and gastric adenocarcinoma. Unfortunately, none of
the available treatment regimens can completely eradicate this pathogen. Factors such as acidic
stomach conditions, trapping of antibiotics in the gastric mucosa, side effects of antibiotics,
dormancy phenomenon, and antibiotic resistance all contribute in reducing the rate of infection
eradication. In recent decades, probiotic therapy has been considered as one of the most desirable
ways to treat the infection of this bacterium."   should be deleted. And please add more concise
and important information focus on probiotic effect on H.P therapy.
Please review this paper.
user
Title: Probiotics as the live microscopic fighters against Helicobacter pylori gastric infections
Version: 0 Date: 13 Aug 2021
Reviewer's report:
I have several comments:
1. Please provide one section about probiotic supplementation effect on gut microbiome
during H pylori therapy and include more ref about this issue  e.g. Helicobacter 2016
Dec;21(6):493-503. Microb Pathog. 2017 Aug;109:156-161. Eur J Clin Microbiol Infect Dis.
2020 Jul;39(7):1365-1372.
2.Table 4: Please provide P value or statistical significance in each study. And I don't know if
the following study "Iran J Pediatr. 2013 Feb; 23(1): 79–84." was listed in Table 4
3. Table 5:Please revise the title :"Summary of current meta-analysis on the efficacy of probiotics
in cure of H. pylori infection" The listing study was not meta analysis and may add the term
"adult population "
4. Please re-write abstract. The following sentence "Helicobacter pylori (H. pylori) is one of
the most common causes of bacterial infections worldwide, mostly colonized in the human
stomach during childhood. Chronic infection with this bacterium increases the risk of developing
severe complications such as peptic ulcer and gastric adenocarcinoma. Unfortunately, none of
the available treatment regimens can completely eradicate this pathogen. Factors such as acidic
stomach conditions, trapping of antibiotics in the gastric mucosa, side effects of antibiotics,
dormancy phenomenon, and antibiotic resistance all contribute in reducing the rate of infection
eradication. In recent decades, probiotic therapy has been considered as one of the most desirable
ways to treat the infection of this bacterium."   should be deleted. And please add more concise
and important information focus on probiotic effect on H.P therapy.
assistant