Reviewer's report
Title:Clinicopathological characteristics of high expression of Bmi-1 in
esophageal adenocarcinoma and squamous cell carcinoma
Version: 3Date:31 July 2012
Reviewer: Reuben Kim
Reviewer's report:
Minor essential revisions
In this manuscript entitled, “Clinicopathological characteristics of high expression
of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma,” Choy et
al. examined the correlation between the expression of Bmi-1 in esophageal
cancers and clinicopathological parameters. From this study, they conclude that
Bmi-1 expression positively correlates with different histological grades of
esophageal tissues from normal to cancers. The authors ruled out Bmi-1
amplification as a reason form the high expression of Bmi-1 in tissues. From the
study, the authors concluded that Bmi-1 may play an important role in early
carcinogenesis in esophageal adenocarcinoma. The current study is interesting,
and the results were supported by the findings. However, prior to publication
consideration in GMC Gasteroenterology, the manuscript needs grammatical
corrections.
Major Issues
1) There are typos in the Abstract; “Bmi-1” is either spelled as “Bmil-1” or
“BMI-1.”
2) All the references should come before the period. For example, not “.[1,2]” but
“[1,2].”
3) In method section, “5-µ” should be “5 µm.”
4) Please include the reference for “Dulak et al.”
5) When scoring IHC, the authors did not count the cytoplasmic staining patterns
for Bmi-1. Cytoplasmic staining of Bmi-1 on tissue sections was frequently noted.
Therefore, authors should include rationale as to why cytoplasmic staining was
not counted. Authors should consider citing Cohen et al., MCB, 1996.
6) It is recommended to put the results of multivariate survival analysis of clinical
covariates including p values in the table form.
Minor issues
1) Any reasons to leave blank columns in the Table 1 and Table 2?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Clinicopathological characteristics of high expression of Bmi-1 in
esophageal adenocarcinoma and squamous cell carcinoma
Version: 3Date:31 July 2012
Reviewer: Reuben Kim
Reviewer's report:
Minor essential revisions
In this manuscript entitled, “Clinicopathological characteristics of high expression
of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma,” Choy et
al. examined the correlation between the expression of Bmi-1 in esophageal
cancers and clinicopathological parameters. From this study, they conclude that
Bmi-1 expression positively correlates with different histological grades of
esophageal tissues from normal to cancers. The authors ruled out Bmi-1
amplification as a reason form the high expression of Bmi-1 in tissues. From the
study, the authors concluded that Bmi-1 may play an important role in early
carcinogenesis in esophageal adenocarcinoma. The current study is interesting,
and the results were supported by the findings. However, prior to publication
consideration in GMC Gasteroenterology, the manuscript needs grammatical
corrections.
Major Issues
1) There are typos in the Abstract; “Bmi-1” is either spelled as “Bmil-1” or
“BMI-1.”
2) All the references should come before the period. For example, not “.[1,2]” but
“[1,2].”
3) In method section, “5-µ” should be “5 µm.”
4) Please include the reference for “Dulak et al.”
5) When scoring IHC, the authors did not count the cytoplasmic staining patterns
for Bmi-1. Cytoplasmic staining of Bmi-1 on tissue sections was frequently noted.
Therefore, authors should include rationale as to why cytoplasmic staining was
not counted. Authors should consider citing Cohen et al., MCB, 1996.
6) It is recommended to put the results of multivariate survival analysis of clinical
covariates including p values in the table form.
Minor issues
1) Any reasons to leave blank columns in the Table 1 and Table 2?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Clinicopathological characteristics of high expression of Bmi-1 in
esophageal adenocarcinoma and squamous cell carcinoma
Version: 3Date:31 July 2012
Reviewer: Reuben Kim
Reviewer's report:
Minor essential revisions
In this manuscript entitled, “Clinicopathological characteristics of high expression
of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma,” Choy et
al. examined the correlation between the expression of Bmi-1 in esophageal
cancers and clinicopathological parameters. From this study, they conclude that
Bmi-1 expression positively correlates with different histological grades of
esophageal tissues from normal to cancers. The authors ruled out Bmi-1
amplification as a reason form the high expression of Bmi-1 in tissues. From the
study, the authors concluded that Bmi-1 may play an important role in early
carcinogenesis in esophageal adenocarcinoma. The current study is interesting,
and the results were supported by the findings. However, prior to publication
consideration in GMC Gasteroenterology, the manuscript needs grammatical
corrections.
Major Issues
1) There are typos in the Abstract; “Bmi-1” is either spelled as “Bmil-1” or
“BMI-1.”
2) All the references should come before the period. For example, not “.[1,2]” but
“[1,2].”
3) In method section, “5-µ” should be “5 µm.”
4) Please include the reference for “Dulak et al.”
5) When scoring IHC, the authors did not count the cytoplasmic staining patterns
for Bmi-1. Cytoplasmic staining of Bmi-1 on tissue sections was frequently noted.
Therefore, authors should include rationale as to why cytoplasmic staining was
not counted. Authors should consider citing Cohen et al., MCB, 1996.
6) It is recommended to put the results of multivariate survival analysis of clinical
covariates including p values in the table form.
Minor issues
1) Any reasons to leave blank columns in the Table 1 and Table 2?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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