Title: Downregulation of SMOC1 is associated with progression of colorectal traditional
serrated adenomas
Version: 1 Date: 12 Jan 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This study sought to demonstrate the correlation between SMOC1
gene methylation and TSAs. It relies heavily on similar findings by the same authors (Reference
12) that they refer to extensively all over the manuscript. Nothing new as a result. The cohort
in thdif 1018 Oncotarget paper (reference 12) is even bigger than the one in the present study,
further undermining the added value of this study.
ADDITIONAL REQUESTS/SUGGESTIONS:
In addition to the lack of originality (Authors own 2018 Oncotarget paper-Reference 12), the
results section in Abstract NOT CLEAR and needs rewriting.
Title: Downregulation of SMOC1 is associated with progression of colorectal traditional
serrated adenomas
Version: 1 Date: 12 Jan 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This study sought to demonstrate the correlation between SMOC1
gene methylation and TSAs. It relies heavily on similar findings by the same authors (Reference
12) that they refer to extensively all over the manuscript. Nothing new as a result. The cohort
in thdif 1018 Oncotarget paper (reference 12) is even bigger than the one in the present study,
further undermining the added value of this study.
ADDITIONAL REQUESTS/SUGGESTIONS:
In addition to the lack of originality (Authors own 2018 Oncotarget paper-Reference 12), the
results section in Abstract NOT CLEAR and needs rewriting.
Please review this paper.
user
Title: Downregulation of SMOC1 is associated with progression of colorectal traditional
serrated adenomas
Version: 1 Date: 12 Jan 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Maybe - with major revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This study sought to demonstrate the correlation between SMOC1
gene methylation and TSAs. It relies heavily on similar findings by the same authors (Reference
12) that they refer to extensively all over the manuscript. Nothing new as a result. The cohort
in thdif 1018 Oncotarget paper (reference 12) is even bigger than the one in the present study,
further undermining the added value of this study.
ADDITIONAL REQUESTS/SUGGESTIONS:
In addition to the lack of originality (Authors own 2018 Oncotarget paper-Reference 12), the
results section in Abstract NOT CLEAR and needs rewriting.
assistant