Title: Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS
and FIB-4 in NAFLD patients
Version: 2 Date: 08 Sep 2024
Reviewer's report:
Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS and
FIB-4 in NAFLD patients
This is a very interesting study, I got acquainted with the information and results that are of
practical importance with great interest. However, I have a few comments.
1. Sarcopenia was diagnosed by measuring the thickness of the rectus femoris by
ultrasonography.  Muscle strength and physical performance were not determined. There are
no cumulative signs of sarcopenia. Please read and add this consensus to references: https://
doi.org/10.1093/ageing/afy169. It is advisable to rename the article, namely, to indicate not
"Association of sarcopenia with ...", but "Association of ultrasound signs of sarcopenia with ...".
2. The results in the abstract look like this: «According to statistical analysis, there is a significant
association between the level of ferritin in serum and sarcopenia. Besides, there is a significant
association between NFS, Fib4, and sarcopenia». I would like to see more specific formulations
here (what is the positive correlation? what is the prevalence of ultrasound signs of sarcopenia
in the study participants?). The results in the article take up 1 page and 3 tables. The tables
indicate that 82% of patients are overweight. It is not clear how many patients had ultrasound
signs of sarcopenia. A significant positive correlation between sarcopenia and ferritin, NFS and
Fib4 was revealed. And what follows from this? Please describe it in more detail.
3. Discussion: - the Kwon Y. study https://doi.org/10.3390/jcm9103355 - This comparison in
the discussion is not correct, given the difference in the age of patients in the two studies.
4. The authors write that serum ferritin levels are associated with criteria that determine fibrosis.
Perhaps it would be appropriate to write in more detail about ferritin in the «Introduction» or
«Discussion» and explain why it was chosen for this study. It is necessary to explain to the
reader the logic of the authors.
5. In the same part, it is desirable to note about sarcopenic obesity and make analogies with
other studies.
Title: Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS
and FIB-4 in NAFLD patients
Version: 2 Date: 08 Sep 2024
Reviewer's report:
Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS and
FIB-4 in NAFLD patients
This is a very interesting study, I got acquainted with the information and results that are of
practical importance with great interest. However, I have a few comments.
1. Sarcopenia was diagnosed by measuring the thickness of the rectus femoris by
ultrasonography.  Muscle strength and physical performance were not determined. There are
no cumulative signs of sarcopenia. Please read and add this consensus to references: https://
doi.org/10.1093/ageing/afy169. It is advisable to rename the article, namely, to indicate not
"Association of sarcopenia with ...", but "Association of ultrasound signs of sarcopenia with ...".
2. The results in the abstract look like this: «According to statistical analysis, there is a significant
association between the level of ferritin in serum and sarcopenia. Besides, there is a significant
association between NFS, Fib4, and sarcopenia». I would like to see more specific formulations
here (what is the positive correlation? what is the prevalence of ultrasound signs of sarcopenia
in the study participants?). The results in the article take up 1 page and 3 tables. The tables
indicate that 82% of patients are overweight. It is not clear how many patients had ultrasound
signs of sarcopenia. A significant positive correlation between sarcopenia and ferritin, NFS and
Fib4 was revealed. And what follows from this? Please describe it in more detail.
3. Discussion: - the Kwon Y. study https://doi.org/10.3390/jcm9103355 - This comparison in
the discussion is not correct, given the difference in the age of patients in the two studies.
4. The authors write that serum ferritin levels are associated with criteria that determine fibrosis.
Perhaps it would be appropriate to write in more detail about ferritin in the «Introduction» or
«Discussion» and explain why it was chosen for this study. It is necessary to explain to the
reader the logic of the authors.
5. In the same part, it is desirable to note about sarcopenic obesity and make analogies with
other studies.
Please review this paper.
user
Title: Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS
and FIB-4 in NAFLD patients
Version: 2 Date: 08 Sep 2024
Reviewer's report:
Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS and
FIB-4 in NAFLD patients
This is a very interesting study, I got acquainted with the information and results that are of
practical importance with great interest. However, I have a few comments.
1. Sarcopenia was diagnosed by measuring the thickness of the rectus femoris by
ultrasonography.  Muscle strength and physical performance were not determined. There are
no cumulative signs of sarcopenia. Please read and add this consensus to references: https://
doi.org/10.1093/ageing/afy169. It is advisable to rename the article, namely, to indicate not
"Association of sarcopenia with ...", but "Association of ultrasound signs of sarcopenia with ...".
2. The results in the abstract look like this: «According to statistical analysis, there is a significant
association between the level of ferritin in serum and sarcopenia. Besides, there is a significant
association between NFS, Fib4, and sarcopenia». I would like to see more specific formulations
here (what is the positive correlation? what is the prevalence of ultrasound signs of sarcopenia
in the study participants?). The results in the article take up 1 page and 3 tables. The tables
indicate that 82% of patients are overweight. It is not clear how many patients had ultrasound
signs of sarcopenia. A significant positive correlation between sarcopenia and ferritin, NFS and
Fib4 was revealed. And what follows from this? Please describe it in more detail.
3. Discussion: - the Kwon Y. study https://doi.org/10.3390/jcm9103355 - This comparison in
the discussion is not correct, given the difference in the age of patients in the two studies.
4. The authors write that serum ferritin levels are associated with criteria that determine fibrosis.
Perhaps it would be appropriate to write in more detail about ferritin in the «Introduction» or
«Discussion» and explain why it was chosen for this study. It is necessary to explain to the
reader the logic of the authors.
5. In the same part, it is desirable to note about sarcopenic obesity and make analogies with
other studies.
assistant