Reviewer's report
Title:Urine neutrophil gelatinase-associated lipocalin: a diagnostic and
prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients
with AKI-prone conditions.
Version:2Date:29 July 2015
Reviewer: Yuki Ohya
Reviewer's report:
In this article, the authors did prospective study to evaluate the accuracy of
uNGAL as a biomarker for the early identification of AKU in cirrhotic patients.
This is very important and interesting.
Major Compulsory Revisions
1. Authors compared evaluation factors between AKI and No AKI in Table 1 and
Table 2. But, authors should compare evaluation factors between uNGAL>56
ng/mL group and uNGAL<56 group ng/mL in another table. This table would be
helpful to evaluate the uNGAL as a biomarker.
Minor Essential Revisions
1. Tables are very difficult to see. The format should be changed.
2. Authors are using uNGAL and UNGAL. Authors should standardize
abbreviation.
3. Because some papers reported relation increase of uNGAL and malignancy,
author should mention HCC and another malignancy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Urine neutrophil gelatinase-associated lipocalin: a diagnostic and
prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients
with AKI-prone conditions.
Version:2Date:29 July 2015
Reviewer: Yuki Ohya
Reviewer's report:
In this article, the authors did prospective study to evaluate the accuracy of
uNGAL as a biomarker for the early identification of AKU in cirrhotic patients.
This is very important and interesting.
Major Compulsory Revisions
1. Authors compared evaluation factors between AKI and No AKI in Table 1 and
Table 2. But, authors should compare evaluation factors between uNGAL>56
ng/mL group and uNGAL<56 group ng/mL in another table. This table would be
helpful to evaluate the uNGAL as a biomarker.
Minor Essential Revisions
1. Tables are very difficult to see. The format should be changed.
2. Authors are using uNGAL and UNGAL. Authors should standardize
abbreviation.
3. Because some papers reported relation increase of uNGAL and malignancy,
author should mention HCC and another malignancy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Urine neutrophil gelatinase-associated lipocalin: a diagnostic and
prognostic marker for acute kidney injury (AKI) in hospitalized cirrhotic patients
with AKI-prone conditions.
Version:2Date:29 July 2015
Reviewer: Yuki Ohya
Reviewer's report:
In this article, the authors did prospective study to evaluate the accuracy of
uNGAL as a biomarker for the early identification of AKU in cirrhotic patients.
This is very important and interesting.
Major Compulsory Revisions
1. Authors compared evaluation factors between AKI and No AKI in Table 1 and
Table 2. But, authors should compare evaluation factors between uNGAL>56
ng/mL group and uNGAL<56 group ng/mL in another table. This table would be
helpful to evaluate the uNGAL as a biomarker.
Minor Essential Revisions
1. Tables are very difficult to see. The format should be changed.
2. Authors are using uNGAL and UNGAL. Authors should standardize
abbreviation.
3. Because some papers reported relation increase of uNGAL and malignancy,
author should mention HCC and another malignancy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant