Reviewer’s report
Title: 
Preoperative platelet count predicts posttransplant portal vein complications in orthotopic liver
transplantation: a propensity score analysis
Version: 
0 
Date: 
12 Jul 2020
Reviewer's report:
There are many reports about the impact of the post-transplant platelet count on the outcome of livre
transplantation, and also there are some about the pre-transplant platelet count, too. 
Generally, lower
platelet count has been reported with worse outcome. In the contrary, the submitted manuscript mentions
the worse outcome on the incidence of porta vein thrombosis (PVT). I have serious concern about the
message that may be published by this report, as below.
1. The title should be more focused to PVT. 
"Predicts posttransplant morbidity" 
is too wide.
2. There are no data about the change of the platelet count in the immediate post-transplant period. 
If
platelet may have influence of the hemostatic function, the real time count should be clarified in the post-
transplant period. 
3. The incidence of pretransplant PVT is shown in the table, and that shows no difference between the low
and high groups. 
However, as many reports have already shown, pretransplant PVT have positive influence
on the incidence of post-transplant PVT. 
If authors mention about the incidence of the PVT, grade of the
pre-transplant PVT and surgical procedures performed for PVT during the operation. 
Meticulous analysis
may give different result from the present one.
4.The result sounds like a statistical magic. Do authors consider that the smaller the platelet count is the
better? 
Because this result is generally against the consensus about the pretransplant platelet count, larger
sample size is necessary to stress the impact. 
Because platelet count is the continuous number, focused
study about the incidence of PVT using other statistical method is mandatory. 
Publons Reviewer Recognition
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metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such
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published on its webservice if you have registered for such service or help editors to identify candidate
reviewers. Please find the details of processing in Publons’ privacy policy
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Yes
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If an additional statistical review is recommended, please specify what aspects require further assessment
in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this manuscript,
either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an organization that holds or has
applied for patents relating to the content of the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If your
reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (
 http://creativecommons.org/licenses/by/4.0
) if this manuscript is
accepted for publication. Any comments that I do not wish to be included in the published report have
been included as confidential comments to the editor, which will not be published.
If you are not happy for us to publish this report, please contact the editorial office before completing
the review.
If you wish, you can include your name in your published report. Please note you must decide whether
to include your name at the start of the process and confirm this decision whenever prompted. If you
change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name with my report. (default)
Reviewer’s report
Title: 
Preoperative platelet count predicts posttransplant portal vein complications in orthotopic liver
transplantation: a propensity score analysis
Version: 
0 
Date: 
12 Jul 2020
Reviewer's report:
There are many reports about the impact of the post-transplant platelet count on the outcome of livre
transplantation, and also there are some about the pre-transplant platelet count, too. 
Generally, lower
platelet count has been reported with worse outcome. In the contrary, the submitted manuscript mentions
the worse outcome on the incidence of porta vein thrombosis (PVT). I have serious concern about the
message that may be published by this report, as below.
1. The title should be more focused to PVT. 
"Predicts posttransplant morbidity" 
is too wide.
2. There are no data about the change of the platelet count in the immediate post-transplant period. 
If
platelet may have influence of the hemostatic function, the real time count should be clarified in the post-
transplant period. 
3. The incidence of pretransplant PVT is shown in the table, and that shows no difference between the low
and high groups. 
However, as many reports have already shown, pretransplant PVT have positive influence
on the incidence of post-transplant PVT. 
If authors mention about the incidence of the PVT, grade of the
pre-transplant PVT and surgical procedures performed for PVT during the operation. 
Meticulous analysis
may give different result from the present one.
4.The result sounds like a statistical magic. Do authors consider that the smaller the platelet count is the
better? 
Because this result is generally against the consensus about the pretransplant platelet count, larger
sample size is necessary to stress the impact. 
Because platelet count is the continuous number, focused
study about the incidence of PVT using other statistical method is mandatory. 
Publons Reviewer Recognition
. Springer Nature can send verification of this review directly to Publons
(a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on
the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal,
and date of your review submission (the “Review Data”) will then be transmitted to Publons upon
publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt
of this review and update your profile 
as per your settings and their policy. If you are not registered with
Publons, you will receive an email from them asking you to register in order for them to be able to
recognize your review on your new profile page. Publons may use the Review Data to generate derivative
metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such
information. For example, Publons may verify your record as a reviewer by updating your profile
published on its webservice if you have registered for such service or help editors to identify candidate
reviewers. Please find the details of processing in Publons’ privacy policy
https://publons.com/about/terms
Yes
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If an additional statistical review is recommended, please specify what aspects require further assessment
in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this manuscript,
either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an organization that holds or has
applied for patents relating to the content of the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If your
reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (
 http://creativecommons.org/licenses/by/4.0
) if this manuscript is
accepted for publication. Any comments that I do not wish to be included in the published report have
been included as confidential comments to the editor, which will not be published.
If you are not happy for us to publish this report, please contact the editorial office before completing
the review.
If you wish, you can include your name in your published report. Please note you must decide whether
to include your name at the start of the process and confirm this decision whenever prompted. If you
change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name with my report. (default)
Please review this paper.
user
Reviewer’s report
Title: 
Preoperative platelet count predicts posttransplant portal vein complications in orthotopic liver
transplantation: a propensity score analysis
Version: 
0 
Date: 
12 Jul 2020
Reviewer's report:
There are many reports about the impact of the post-transplant platelet count on the outcome of livre
transplantation, and also there are some about the pre-transplant platelet count, too. 
Generally, lower
platelet count has been reported with worse outcome. In the contrary, the submitted manuscript mentions
the worse outcome on the incidence of porta vein thrombosis (PVT). I have serious concern about the
message that may be published by this report, as below.
1. The title should be more focused to PVT. 
"Predicts posttransplant morbidity" 
is too wide.
2. There are no data about the change of the platelet count in the immediate post-transplant period. 
If
platelet may have influence of the hemostatic function, the real time count should be clarified in the post-
transplant period. 
3. The incidence of pretransplant PVT is shown in the table, and that shows no difference between the low
and high groups. 
However, as many reports have already shown, pretransplant PVT have positive influence
on the incidence of post-transplant PVT. 
If authors mention about the incidence of the PVT, grade of the
pre-transplant PVT and surgical procedures performed for PVT during the operation. 
Meticulous analysis
may give different result from the present one.
4.The result sounds like a statistical magic. Do authors consider that the smaller the platelet count is the
better? 
Because this result is generally against the consensus about the pretransplant platelet count, larger
sample size is necessary to stress the impact. 
Because platelet count is the continuous number, focused
study about the incidence of PVT using other statistical method is mandatory. 
Publons Reviewer Recognition
. Springer Nature can send verification of this review directly to Publons
(a subsidiary of Clarivate Analytics). If you would like to take advantage of this service, please click on
the “Yes” option below. Your name, email address, title of the reviewed manuscript, name of the journal,
and date of your review submission (the “Review Data”) will then be transmitted to Publons upon
publication of the manuscript. If you have already registered at Publons, they will notify you of the receipt
of this review and update your profile 
as per your settings and their policy. If you are not registered with
Publons, you will receive an email from them asking you to register in order for them to be able to
recognize your review on your new profile page. Publons may use the Review Data to generate derivative
metadata for the benefit of Publons and you as a reviewer, carefully considering the sensitivity of such
information. For example, Publons may verify your record as a reviewer by updating your profile
published on its webservice if you have registered for such service or help editors to identify candidate
reviewers. Please find the details of processing in Publons’ privacy policy
https://publons.com/about/terms
Yes
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
No
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional
statistical review?
If an additional statistical review is recommended, please specify what aspects require further assessment
in your comments to the editors.
I recommend additional statistical review
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of this manuscript,
either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an organization that holds or has
applied for patents relating to the content of the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If your
reply is yes to any, please give details below.
I declare that I have no competing interests.
Reviewer Publication Consent.
 I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (
 http://creativecommons.org/licenses/by/4.0
) if this manuscript is
accepted for publication. Any comments that I do not wish to be included in the published report have
been included as confidential comments to the editor, which will not be published.
If you are not happy for us to publish this report, please contact the editorial office before completing
the review.
If you wish, you can include your name in your published report. Please note you must decide whether
to include your name at the start of the process and confirm this decision whenever prompted. If you
change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please 
do not
 publish my name with my report. (default)
assistant