Title: Effect of Helicobacter pylori Eradication evaluated using Magnifying Endoscopy with
Narrow- Band Imaging in Mixed-type Early Gastric Cancer
Version: 0 Date: 05 Nov 2023
Reviewer:  Jun-Hyung Cho
Reviewer's report:
I think that the authors showed the valuable data for magnifying NBI finding of mixed-type EGC
with pathologic review. However, some study limitation was found due to the characteristics of
this retrospective study as below;
First, please the characteristics of EGC treated with ESD in the hospital before mixed-type EGC
(n = 311 cases). For example, the numbers of intestinal and diffuse-type EGC cases in Figure 3
are required although they are excluded from this study.
Second, the inflammatory cell infiltration (normal-mild) of neutrophil and monoclear cells is
hard to be understood in the method section, Table 1, 2. Were these pathological analysis
performed in the resected ESD specimen or other biopsy sites? Please describe the methodology
and pathological study process in detail, because statistical significance of only this variable was
found between two groups.
Third, how many cancerous findings among five (loop, mesh, extended, waxy, and corkscrew)
were used in Table 3? Please describe the numbers of corresponding finding were one-two in
D-mix EGC and one-three in U-mix EGC.
Fourth, I think the conclusion in the abstract was overrated on the basis of data results. The last
sentence (42-44 in page 3) is generally well-known in diagnosing EGC regardless of mix-type.
Title: Effect of Helicobacter pylori Eradication evaluated using Magnifying Endoscopy with
Narrow- Band Imaging in Mixed-type Early Gastric Cancer
Version: 0 Date: 05 Nov 2023
Reviewer:  Jun-Hyung Cho
Reviewer's report:
I think that the authors showed the valuable data for magnifying NBI finding of mixed-type EGC
with pathologic review. However, some study limitation was found due to the characteristics of
this retrospective study as below;
First, please the characteristics of EGC treated with ESD in the hospital before mixed-type EGC
(n = 311 cases). For example, the numbers of intestinal and diffuse-type EGC cases in Figure 3
are required although they are excluded from this study.
Second, the inflammatory cell infiltration (normal-mild) of neutrophil and monoclear cells is
hard to be understood in the method section, Table 1, 2. Were these pathological analysis
performed in the resected ESD specimen or other biopsy sites? Please describe the methodology
and pathological study process in detail, because statistical significance of only this variable was
found between two groups.
Third, how many cancerous findings among five (loop, mesh, extended, waxy, and corkscrew)
were used in Table 3? Please describe the numbers of corresponding finding were one-two in
D-mix EGC and one-three in U-mix EGC.
Fourth, I think the conclusion in the abstract was overrated on the basis of data results. The last
sentence (42-44 in page 3) is generally well-known in diagnosing EGC regardless of mix-type.
Please review this paper.
user
Title: Effect of Helicobacter pylori Eradication evaluated using Magnifying Endoscopy with
Narrow- Band Imaging in Mixed-type Early Gastric Cancer
Version: 0 Date: 05 Nov 2023
Reviewer:  Jun-Hyung Cho
Reviewer's report:
I think that the authors showed the valuable data for magnifying NBI finding of mixed-type EGC
with pathologic review. However, some study limitation was found due to the characteristics of
this retrospective study as below;
First, please the characteristics of EGC treated with ESD in the hospital before mixed-type EGC
(n = 311 cases). For example, the numbers of intestinal and diffuse-type EGC cases in Figure 3
are required although they are excluded from this study.
Second, the inflammatory cell infiltration (normal-mild) of neutrophil and monoclear cells is
hard to be understood in the method section, Table 1, 2. Were these pathological analysis
performed in the resected ESD specimen or other biopsy sites? Please describe the methodology
and pathological study process in detail, because statistical significance of only this variable was
found between two groups.
Third, how many cancerous findings among five (loop, mesh, extended, waxy, and corkscrew)
were used in Table 3? Please describe the numbers of corresponding finding were one-two in
D-mix EGC and one-three in U-mix EGC.
Fourth, I think the conclusion in the abstract was overrated on the basis of data results. The last
sentence (42-44 in page 3) is generally well-known in diagnosing EGC regardless of mix-type.
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