Reviewer's report
Title:Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are
neuroprotective on cultured and mast cell co-cultured rat myenteric neurons
Version: 1Date:21 December 2011
Reviewer: Dorit Samocha-Bonet
Reviewer's report:
This is a well-performed and written study of the effect of GLP1, GLP2 and VIP
on cultured rat myenteric neurons.
There is evidence that diabetes is associated with neurodegenerative processes
in the enteric nervous system that eventually lead to the neuropathy and
intestinal dysfunction, including delayed gastric emptying, that is well-established
in diabetes.
The rationale of the study is well-explained and the authors build on previous
knowledge to answer yet unanswered questions in the field.
The authors present their data in a clear way and they are not over-interpreting
their data.
Minor essential revision:
What were the diluting agents used with the different pharmacological agents
and were the control cells treated with the diluent? This should be added to the
'Methods' section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are
neuroprotective on cultured and mast cell co-cultured rat myenteric neurons
Version: 1Date:21 December 2011
Reviewer: Dorit Samocha-Bonet
Reviewer's report:
This is a well-performed and written study of the effect of GLP1, GLP2 and VIP
on cultured rat myenteric neurons.
There is evidence that diabetes is associated with neurodegenerative processes
in the enteric nervous system that eventually lead to the neuropathy and
intestinal dysfunction, including delayed gastric emptying, that is well-established
in diabetes.
The rationale of the study is well-explained and the authors build on previous
knowledge to answer yet unanswered questions in the field.
The authors present their data in a clear way and they are not over-interpreting
their data.
Minor essential revision:
What were the diluting agents used with the different pharmacological agents
and were the control cells treated with the diluent? This should be added to the
'Methods' section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Glucagon-like peptides 1 and 2 and vasoactive intestinal peptide are
neuroprotective on cultured and mast cell co-cultured rat myenteric neurons
Version: 1Date:21 December 2011
Reviewer: Dorit Samocha-Bonet
Reviewer's report:
This is a well-performed and written study of the effect of GLP1, GLP2 and VIP
on cultured rat myenteric neurons.
There is evidence that diabetes is associated with neurodegenerative processes
in the enteric nervous system that eventually lead to the neuropathy and
intestinal dysfunction, including delayed gastric emptying, that is well-established
in diabetes.
The rationale of the study is well-explained and the authors build on previous
knowledge to answer yet unanswered questions in the field.
The authors present their data in a clear way and they are not over-interpreting
their data.
Minor essential revision:
What were the diluting agents used with the different pharmacological agents
and were the control cells treated with the diluent? This should be added to the
'Methods' section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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