Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 4 Date: 01 Sep 2022
Reviewer:  Gilles R. G. Monif
Reviewer's report:
A cleanly constructed manuscript.
It's limitations reside in Crohn's disease having been already well established as an immune-
mediated disease. The discussion of the demography and cost of disease, while well presented,
do little for the presentation of the research data.
Several statements need to be cleaned up: page 3 para 3 line 1-4 CD affects  a very specific
area of the gastrointestinal tract, the ileocecum (Chapter20 Doi: 10.9734/bpi/dmmr/v11/14229D
C .Emerging Trends in Disease and Health Vol.9 may help clarify the disease entity that you are
studying). Only after surgery alters the cite of primary fecal stasis does the site of the disease
move. Oral cavity involvement is a direct consequence of microbial infection  by Mycobacterium
avium subspecies paratuberculosis and the consequence of MAP's immune-mediated  disease
process (see reference 18 & 21)
Page 3, para 4 lines1-3 are best deleted .
Overall, let the data specific for itself:  A cytokine cascade is in evidence in individuals with
Crohn's disease and there is a positive correlation between their level and disease manifestation.
Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 4 Date: 01 Sep 2022
Reviewer:  Gilles R. G. Monif
Reviewer's report:
A cleanly constructed manuscript.
It's limitations reside in Crohn's disease having been already well established as an immune-
mediated disease. The discussion of the demography and cost of disease, while well presented,
do little for the presentation of the research data.
Several statements need to be cleaned up: page 3 para 3 line 1-4 CD affects  a very specific
area of the gastrointestinal tract, the ileocecum (Chapter20 Doi: 10.9734/bpi/dmmr/v11/14229D
C .Emerging Trends in Disease and Health Vol.9 may help clarify the disease entity that you are
studying). Only after surgery alters the cite of primary fecal stasis does the site of the disease
move. Oral cavity involvement is a direct consequence of microbial infection  by Mycobacterium
avium subspecies paratuberculosis and the consequence of MAP's immune-mediated  disease
process (see reference 18 & 21)
Page 3, para 4 lines1-3 are best deleted .
Overall, let the data specific for itself:  A cytokine cascade is in evidence in individuals with
Crohn's disease and there is a positive correlation between their level and disease manifestation.
Please review this paper.
user
Title: The profile of the key pro-inflammatory cytokines in the serum of patients with CD and
their association with the disease severity and activity
Version: 4 Date: 01 Sep 2022
Reviewer:  Gilles R. G. Monif
Reviewer's report:
A cleanly constructed manuscript.
It's limitations reside in Crohn's disease having been already well established as an immune-
mediated disease. The discussion of the demography and cost of disease, while well presented,
do little for the presentation of the research data.
Several statements need to be cleaned up: page 3 para 3 line 1-4 CD affects  a very specific
area of the gastrointestinal tract, the ileocecum (Chapter20 Doi: 10.9734/bpi/dmmr/v11/14229D
C .Emerging Trends in Disease and Health Vol.9 may help clarify the disease entity that you are
studying). Only after surgery alters the cite of primary fecal stasis does the site of the disease
move. Oral cavity involvement is a direct consequence of microbial infection  by Mycobacterium
avium subspecies paratuberculosis and the consequence of MAP's immune-mediated  disease
process (see reference 18 & 21)
Page 3, para 4 lines1-3 are best deleted .
Overall, let the data specific for itself:  A cytokine cascade is in evidence in individuals with
Crohn's disease and there is a positive correlation between their level and disease manifestation.
assistant