Reviewer's report
Title:Diagnostic accuracy of reused Pronto Dry(R) test and CLOtest(R) in the
detection of Helicobacter pylori infection
Version:1Date:26 June 2015
Reviewer: Alejandro Piscoya
Reviewer's report:
Major Compulsory Revision
Even though Likelihood ratios have been calculated for CLOtest (Table 1), they
are not described in Diagnostic Accuracy as the LR´s for Pronto Dry are. The
discussion says LR negative is not good for CLOtest but actually is quite good, it
will reduce probability from 17% (prevalence used as pre test probability) to less
than 2%.. So reuse of CLOtest will work borth both positive and negative results
Minor Essential Revision
Cost is an important issue here and should be discussed with numbers, how
much on average is the cost of Pronto Dry and CLOtest in order to better
understand the importance for low resource countries
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Diagnostic accuracy of reused Pronto Dry(R) test and CLOtest(R) in the
detection of Helicobacter pylori infection
Version:1Date:26 June 2015
Reviewer: Alejandro Piscoya
Reviewer's report:
Major Compulsory Revision
Even though Likelihood ratios have been calculated for CLOtest (Table 1), they
are not described in Diagnostic Accuracy as the LR´s for Pronto Dry are. The
discussion says LR negative is not good for CLOtest but actually is quite good, it
will reduce probability from 17% (prevalence used as pre test probability) to less
than 2%.. So reuse of CLOtest will work borth both positive and negative results
Minor Essential Revision
Cost is an important issue here and should be discussed with numbers, how
much on average is the cost of Pronto Dry and CLOtest in order to better
understand the importance for low resource countries
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Diagnostic accuracy of reused Pronto Dry(R) test and CLOtest(R) in the
detection of Helicobacter pylori infection
Version:1Date:26 June 2015
Reviewer: Alejandro Piscoya
Reviewer's report:
Major Compulsory Revision
Even though Likelihood ratios have been calculated for CLOtest (Table 1), they
are not described in Diagnostic Accuracy as the LR´s for Pronto Dry are. The
discussion says LR negative is not good for CLOtest but actually is quite good, it
will reduce probability from 17% (prevalence used as pre test probability) to less
than 2%.. So reuse of CLOtest will work borth both positive and negative results
Minor Essential Revision
Cost is an important issue here and should be discussed with numbers, how
much on average is the cost of Pronto Dry and CLOtest in order to better
understand the importance for low resource countries
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
assistant