Title: Liver histology pattern of young patients with inactive chronic hepatitis B virus infection
from a Hospital in South West Nigeria
Version: 4 Date: 02 Sep 2024
Reviewer's report:
The revised manuscript on liver histology patterns in young Nigerian patients with inactive
chronic hepatitis B virus infection has commendable improvements. The authors have clearly put
significant effort into addressing reviewer comments.  The discussion of non-invasive markers
and their limitations has been well-handled, providing valuable context for the study's findings.
I have few additional comments on the revised version.
- I appreciated  inclusion of a discussion about the degree of unexplained hyperbilirubinemia ,
although I found the explanation provided  not fully convincing. The cross-sectional nature of the
study might have affected this observation, limiting the ability to draw definitive conclusions.
- The utility of the pie chart is questionable, as it doesn't appear to convey key information more
effectively than alternative visualizations. Consider replacing it with a more informative graphic
or dropping it all-together
- Some tables appear busy, especially with the inclusion of different reference values for
laboratory tests. Consider simplifying by moving detailed reference values to footnotes or a
separate appendix.
- For tables with separate columns for raw frequencies and percentages, combine these into a
single column, presenting data as "n (%)". Authors could utilize an approach of comparative
analysis for most tables to add more insight into the study participants.
Title: Liver histology pattern of young patients with inactive chronic hepatitis B virus infection
from a Hospital in South West Nigeria
Version: 4 Date: 02 Sep 2024
Reviewer's report:
The revised manuscript on liver histology patterns in young Nigerian patients with inactive
chronic hepatitis B virus infection has commendable improvements. The authors have clearly put
significant effort into addressing reviewer comments.  The discussion of non-invasive markers
and their limitations has been well-handled, providing valuable context for the study's findings.
I have few additional comments on the revised version.
- I appreciated  inclusion of a discussion about the degree of unexplained hyperbilirubinemia ,
although I found the explanation provided  not fully convincing. The cross-sectional nature of the
study might have affected this observation, limiting the ability to draw definitive conclusions.
- The utility of the pie chart is questionable, as it doesn't appear to convey key information more
effectively than alternative visualizations. Consider replacing it with a more informative graphic
or dropping it all-together
- Some tables appear busy, especially with the inclusion of different reference values for
laboratory tests. Consider simplifying by moving detailed reference values to footnotes or a
separate appendix.
- For tables with separate columns for raw frequencies and percentages, combine these into a
single column, presenting data as "n (%)". Authors could utilize an approach of comparative
analysis for most tables to add more insight into the study participants.
Please review this paper.
user
Title: Liver histology pattern of young patients with inactive chronic hepatitis B virus infection
from a Hospital in South West Nigeria
Version: 4 Date: 02 Sep 2024
Reviewer's report:
The revised manuscript on liver histology patterns in young Nigerian patients with inactive
chronic hepatitis B virus infection has commendable improvements. The authors have clearly put
significant effort into addressing reviewer comments.  The discussion of non-invasive markers
and their limitations has been well-handled, providing valuable context for the study's findings.
I have few additional comments on the revised version.
- I appreciated  inclusion of a discussion about the degree of unexplained hyperbilirubinemia ,
although I found the explanation provided  not fully convincing. The cross-sectional nature of the
study might have affected this observation, limiting the ability to draw definitive conclusions.
- The utility of the pie chart is questionable, as it doesn't appear to convey key information more
effectively than alternative visualizations. Consider replacing it with a more informative graphic
or dropping it all-together
- Some tables appear busy, especially with the inclusion of different reference values for
laboratory tests. Consider simplifying by moving detailed reference values to footnotes or a
separate appendix.
- For tables with separate columns for raw frequencies and percentages, combine these into a
single column, presenting data as "n (%)". Authors could utilize an approach of comparative
analysis for most tables to add more insight into the study participants.
assistant