Reviewer's report
Title:Safety and effectiveness using dexmedetomidine sedation versus propofol
TCI/alfentanil sedation during oesophagus interventions (SEDEX): A randomized
trial
Version: 1Date:12 July 2013
Reviewer: Reino Pöyhiä
Reviewer's report:
Major revisions: More information is needed about the following issues: a)The
dosing of dexmedetomidine should be clarified in a detailed way. b) What is the
time perspective the desired sedation level would be gained using - i.e. how
many minutes before the procedure the administration of dexmedetomidine will
be initiated?
Minor issues: The authors should add the study by Dr Mazanikov et al. Surg
Endosc. 2013 Jun;27(6):2163-8 in the reference list and consider their protocol in
the light of the results of that study.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Safety and effectiveness using dexmedetomidine sedation versus propofol
TCI/alfentanil sedation during oesophagus interventions (SEDEX): A randomized
trial
Version: 1Date:12 July 2013
Reviewer: Reino Pöyhiä
Reviewer's report:
Major revisions: More information is needed about the following issues: a)The
dosing of dexmedetomidine should be clarified in a detailed way. b) What is the
time perspective the desired sedation level would be gained using - i.e. how
many minutes before the procedure the administration of dexmedetomidine will
be initiated?
Minor issues: The authors should add the study by Dr Mazanikov et al. Surg
Endosc. 2013 Jun;27(6):2163-8 in the reference list and consider their protocol in
the light of the results of that study.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Safety and effectiveness using dexmedetomidine sedation versus propofol
TCI/alfentanil sedation during oesophagus interventions (SEDEX): A randomized
trial
Version: 1Date:12 July 2013
Reviewer: Reino Pöyhiä
Reviewer's report:
Major revisions: More information is needed about the following issues: a)The
dosing of dexmedetomidine should be clarified in a detailed way. b) What is the
time perspective the desired sedation level would be gained using - i.e. how
many minutes before the procedure the administration of dexmedetomidine will
be initiated?
Minor issues: The authors should add the study by Dr Mazanikov et al. Surg
Endosc. 2013 Jun;27(6):2163-8 in the reference list and consider their protocol in
the light of the results of that study.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant