Reviewer's report
Title:Effectiveness and Safety of Ferric Carboxymaltose Treatment in Children
and Adolescents with Inflammatory Bowel Disease
Version:2Date:5 June 2014
Reviewer: juergen stein
Reviewer's report:
In their retrospective study entitled “Effectiveness and Safety of Ferric
Carboxymaltose; Treatment in Children and Adolescents with Inflammatory
Bowel Disease” the authors presented for the first time important data on the use
of FCM in the pediatric population. The paper is well written, however some
points are too imprecisely formulated. In general, more references should be
cited.
Background:
Page 5, Line 11: this is incorrect; there three different forms of iron deficiency
anaemia in IBD: IDA, ACD, and combined IDA/ACD, which is not uncommon
(see Stein et al. Nat Rev. Gastroenterol Hepatol 2010, Blumenstein et al. J
Crohn´s Colitis 2014)
Page 6, line 4: …aggravating intestinal inflammation: please cite reference
Methods:
Definition of Anaemia: What do the authors mean by “defined by the local
laboratory”? What are the exact values? Are these values different from the
WHO classification?
Claasification of IDA: What is meant by “below the lower reference of the lab”?
Precise values should be defined according to recently described algorithms
(Weiss G, Goodnough LT. N Engl J Med 2005) as done by Blumenstein et al. J
Crohn´s Colitis 2014 or Voegtlin et al. J Crohn´s Colitis 2010.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Effectiveness and Safety of Ferric Carboxymaltose Treatment in Children
and Adolescents with Inflammatory Bowel Disease
Version:2Date:5 June 2014
Reviewer: juergen stein
Reviewer's report:
In their retrospective study entitled “Effectiveness and Safety of Ferric
Carboxymaltose; Treatment in Children and Adolescents with Inflammatory
Bowel Disease” the authors presented for the first time important data on the use
of FCM in the pediatric population. The paper is well written, however some
points are too imprecisely formulated. In general, more references should be
cited.
Background:
Page 5, Line 11: this is incorrect; there three different forms of iron deficiency
anaemia in IBD: IDA, ACD, and combined IDA/ACD, which is not uncommon
(see Stein et al. Nat Rev. Gastroenterol Hepatol 2010, Blumenstein et al. J
Crohn´s Colitis 2014)
Page 6, line 4: …aggravating intestinal inflammation: please cite reference
Methods:
Definition of Anaemia: What do the authors mean by “defined by the local
laboratory”? What are the exact values? Are these values different from the
WHO classification?
Claasification of IDA: What is meant by “below the lower reference of the lab”?
Precise values should be defined according to recently described algorithms
(Weiss G, Goodnough LT. N Engl J Med 2005) as done by Blumenstein et al. J
Crohn´s Colitis 2014 or Voegtlin et al. J Crohn´s Colitis 2010.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Effectiveness and Safety of Ferric Carboxymaltose Treatment in Children
and Adolescents with Inflammatory Bowel Disease
Version:2Date:5 June 2014
Reviewer: juergen stein
Reviewer's report:
In their retrospective study entitled “Effectiveness and Safety of Ferric
Carboxymaltose; Treatment in Children and Adolescents with Inflammatory
Bowel Disease” the authors presented for the first time important data on the use
of FCM in the pediatric population. The paper is well written, however some
points are too imprecisely formulated. In general, more references should be
cited.
Background:
Page 5, Line 11: this is incorrect; there three different forms of iron deficiency
anaemia in IBD: IDA, ACD, and combined IDA/ACD, which is not uncommon
(see Stein et al. Nat Rev. Gastroenterol Hepatol 2010, Blumenstein et al. J
Crohn´s Colitis 2014)
Page 6, line 4: …aggravating intestinal inflammation: please cite reference
Methods:
Definition of Anaemia: What do the authors mean by “defined by the local
laboratory”? What are the exact values? Are these values different from the
WHO classification?
Claasification of IDA: What is meant by “below the lower reference of the lab”?
Precise values should be defined according to recently described algorithms
(Weiss G, Goodnough LT. N Engl J Med 2005) as done by Blumenstein et al. J
Crohn´s Colitis 2014 or Voegtlin et al. J Crohn´s Colitis 2010.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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