Reviewer's report
Title:Abnormal fecal microbiota community and functions in patients with
hepatitis B liver cirrhosis as revealed by a metagenomic approach
Version:4Date:11 December 2013
Reviewer: Isabella Inden
Reviewer's report:
Major compulsatory revisions
1. There is no correlation between the different viral load and the and microbiota
community and functions, but there is a correlation between patient and control
group. The definition of the control group is only done by HBV-DNA and cirrhosis
yes or no. Anti-HBc is completly ignored.
2. The relevance of the article and for the management is still poor- if there is no
difference in microbiota community between the different cirrhotic causes, so the
importance of the results are still circumstantial.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Reviewer's report
Title:Abnormal fecal microbiota community and functions in patients with
hepatitis B liver cirrhosis as revealed by a metagenomic approach
Version:4Date:11 December 2013
Reviewer: Isabella Inden
Reviewer's report:
Major compulsatory revisions
1. There is no correlation between the different viral load and the and microbiota
community and functions, but there is a correlation between patient and control
group. The definition of the control group is only done by HBV-DNA and cirrhosis
yes or no. Anti-HBc is completly ignored.
2. The relevance of the article and for the management is still poor- if there is no
difference in microbiota community between the different cirrhotic causes, so the
importance of the results are still circumstantial.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Please review this paper.
user
Reviewer's report
Title:Abnormal fecal microbiota community and functions in patients with
hepatitis B liver cirrhosis as revealed by a metagenomic approach
Version:4Date:11 December 2013
Reviewer: Isabella Inden
Reviewer's report:
Major compulsatory revisions
1. There is no correlation between the different viral load and the and microbiota
community and functions, but there is a correlation between patient and control
group. The definition of the control group is only done by HBV-DNA and cirrhosis
yes or no. Anti-HBc is completly ignored.
2. The relevance of the article and for the management is still poor- if there is no
difference in microbiota community between the different cirrhotic causes, so the
importance of the results are still circumstantial.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
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