Title: The disease course in microscopic colitis may be influenced by hormonal factors
Version: 2 Date: 05 Feb 2025
Reviewer's report:
Main critique is around the contraceptive data. Not sure it makes physiologic sense to combine
all contraceptives into one group, though I understand it makes statistical sense. IUDs, for
example, have very little systemic effects in theory. Also this would benefit from description of
what the "other" contraceptives were to ensure they were hormonal based methods.
Not sure what authors mean in discussion "Since the age at study inclusion was higher in patients
that had bilateral oophorectomy the longer duration and more treatment rounds could very
well be explained by this fact. " In the results, authors state "Even though the age at inclusion
was higher; 75 compared to 71 years (in line with the longer disease duration), respectively
(p=0.001)., the age at diagnosis was the same in both groups; 60 years." These sentences seem
to be contradictory? Please reword/rewrite.
Overall an interesting paper. Some rewording would be beneficial to help reader more easily
understand.
Title: The disease course in microscopic colitis may be influenced by hormonal factors
Version: 2 Date: 05 Feb 2025
Reviewer's report:
Main critique is around the contraceptive data. Not sure it makes physiologic sense to combine
all contraceptives into one group, though I understand it makes statistical sense. IUDs, for
example, have very little systemic effects in theory. Also this would benefit from description of
what the "other" contraceptives were to ensure they were hormonal based methods.
Not sure what authors mean in discussion "Since the age at study inclusion was higher in patients
that had bilateral oophorectomy the longer duration and more treatment rounds could very
well be explained by this fact. " In the results, authors state "Even though the age at inclusion
was higher; 75 compared to 71 years (in line with the longer disease duration), respectively
(p=0.001)., the age at diagnosis was the same in both groups; 60 years." These sentences seem
to be contradictory? Please reword/rewrite.
Overall an interesting paper. Some rewording would be beneficial to help reader more easily
understand.
Please review this paper.
user
Title: The disease course in microscopic colitis may be influenced by hormonal factors
Version: 2 Date: 05 Feb 2025
Reviewer's report:
Main critique is around the contraceptive data. Not sure it makes physiologic sense to combine
all contraceptives into one group, though I understand it makes statistical sense. IUDs, for
example, have very little systemic effects in theory. Also this would benefit from description of
what the "other" contraceptives were to ensure they were hormonal based methods.
Not sure what authors mean in discussion "Since the age at study inclusion was higher in patients
that had bilateral oophorectomy the longer duration and more treatment rounds could very
well be explained by this fact. " In the results, authors state "Even though the age at inclusion
was higher; 75 compared to 71 years (in line with the longer disease duration), respectively
(p=0.001)., the age at diagnosis was the same in both groups; 60 years." These sentences seem
to be contradictory? Please reword/rewrite.
Overall an interesting paper. Some rewording would be beneficial to help reader more easily
understand.
assistant