Reviewer's report
Title:Rapid Induction of Orthotopic Hepatocellular Carcinoma in
Immune-competent Rats by Ultrasound-guided Method and the Subsequent
Metronomic Chemotherapy
Version: 2Date:3 May 2010
Reviewer: Francesco Bertolini
Reviewer's report:
Major:
- The concept of metronomic chemotherapy is not from Hanahan. The two
seminal papers in the field are from Browder/folkman (Cancer Res), and from the
Kerbel lab (J Clin Invest).
- A treatment for only 7 days, albeit daily, can not be considered as metronomic.
In fact, the concept of metronomic chemotherapy implies a long treatment with
no breaks, and 7 days are a short period. Authors should a) discuss this issue or
b) report the results of their preclinical findings as "7-day treatment" and not as
metronomic or c) study the effect of this drug for a longer period of time.
- The preclinical efficacy of metronomic chemotherapy in HCC has beeen
recently reported by the Kerbel lab (Tang et al, Neoplasia 2010;12:264-74).
These data should be discussed and compared with results reported in the
current manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Rapid Induction of Orthotopic Hepatocellular Carcinoma in
Immune-competent Rats by Ultrasound-guided Method and the Subsequent
Metronomic Chemotherapy
Version: 2Date:3 May 2010
Reviewer: Francesco Bertolini
Reviewer's report:
Major:
- The concept of metronomic chemotherapy is not from Hanahan. The two
seminal papers in the field are from Browder/folkman (Cancer Res), and from the
Kerbel lab (J Clin Invest).
- A treatment for only 7 days, albeit daily, can not be considered as metronomic.
In fact, the concept of metronomic chemotherapy implies a long treatment with
no breaks, and 7 days are a short period. Authors should a) discuss this issue or
b) report the results of their preclinical findings as "7-day treatment" and not as
metronomic or c) study the effect of this drug for a longer period of time.
- The preclinical efficacy of metronomic chemotherapy in HCC has beeen
recently reported by the Kerbel lab (Tang et al, Neoplasia 2010;12:264-74).
These data should be discussed and compared with results reported in the
current manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Rapid Induction of Orthotopic Hepatocellular Carcinoma in
Immune-competent Rats by Ultrasound-guided Method and the Subsequent
Metronomic Chemotherapy
Version: 2Date:3 May 2010
Reviewer: Francesco Bertolini
Reviewer's report:
Major:
- The concept of metronomic chemotherapy is not from Hanahan. The two
seminal papers in the field are from Browder/folkman (Cancer Res), and from the
Kerbel lab (J Clin Invest).
- A treatment for only 7 days, albeit daily, can not be considered as metronomic.
In fact, the concept of metronomic chemotherapy implies a long treatment with
no breaks, and 7 days are a short period. Authors should a) discuss this issue or
b) report the results of their preclinical findings as "7-day treatment" and not as
metronomic or c) study the effect of this drug for a longer period of time.
- The preclinical efficacy of metronomic chemotherapy in HCC has beeen
recently reported by the Kerbel lab (Tang et al, Neoplasia 2010;12:264-74).
These data should be discussed and compared with results reported in the
current manuscript.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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