Title: Development of a Novel Immune-Related lncRNA Prognostic Signature for Patients with
Hepatocellular Carcinoma
Version: 3 Date: 22 Jul 2022
Reviewer's report:
Overall, manuscript is well written and analysis is rigorous. I have few concerns that should
address in the manuscript.
1. Abstract, “ Principal basis of relevant deaths” revise this sentence.
2. Do not need to mention the data filtration process in the abstract.
3. The introduction lacks the details on roles of lncRNA in HCC prognosis and diagnosis.
Authors should elaborate on previous literature and method on identification of lncRNA
signatures in HCC prognosis. There are several studies on identifying lncRNAs or genes in
various cancers, authors should describe their approach and advantages over previous methods.
4. Citation is missing for the “the Immport database”
5. “Excluding the patients with survival time less than 30 days, to improve the accuracy of the
study, with 342 patients remaining”. This sentence is repetitive.
6. What is meaning of irregular split?
7. Line 84, elaborate FPKM.
8. Section 2.6, Is lncRNA expression in high and low expression groups significant or not? What
is the p-value?
9. Remove the repetitive sentences in discussion.
10. Be consistent with the wording, HCC or LIHC? carefully check for typos and grammatical
errors throughout the manuscript.
Title: Development of a Novel Immune-Related lncRNA Prognostic Signature for Patients with
Hepatocellular Carcinoma
Version: 3 Date: 22 Jul 2022
Reviewer's report:
Overall, manuscript is well written and analysis is rigorous. I have few concerns that should
address in the manuscript.
1. Abstract, “ Principal basis of relevant deaths” revise this sentence.
2. Do not need to mention the data filtration process in the abstract.
3. The introduction lacks the details on roles of lncRNA in HCC prognosis and diagnosis.
Authors should elaborate on previous literature and method on identification of lncRNA
signatures in HCC prognosis. There are several studies on identifying lncRNAs or genes in
various cancers, authors should describe their approach and advantages over previous methods.
4. Citation is missing for the “the Immport database”
5. “Excluding the patients with survival time less than 30 days, to improve the accuracy of the
study, with 342 patients remaining”. This sentence is repetitive.
6. What is meaning of irregular split?
7. Line 84, elaborate FPKM.
8. Section 2.6, Is lncRNA expression in high and low expression groups significant or not? What
is the p-value?
9. Remove the repetitive sentences in discussion.
10. Be consistent with the wording, HCC or LIHC? carefully check for typos and grammatical
errors throughout the manuscript.
Please review this paper.
user
Title: Development of a Novel Immune-Related lncRNA Prognostic Signature for Patients with
Hepatocellular Carcinoma
Version: 3 Date: 22 Jul 2022
Reviewer's report:
Overall, manuscript is well written and analysis is rigorous. I have few concerns that should
address in the manuscript.
1. Abstract, “ Principal basis of relevant deaths” revise this sentence.
2. Do not need to mention the data filtration process in the abstract.
3. The introduction lacks the details on roles of lncRNA in HCC prognosis and diagnosis.
Authors should elaborate on previous literature and method on identification of lncRNA
signatures in HCC prognosis. There are several studies on identifying lncRNAs or genes in
various cancers, authors should describe their approach and advantages over previous methods.
4. Citation is missing for the “the Immport database”
5. “Excluding the patients with survival time less than 30 days, to improve the accuracy of the
study, with 342 patients remaining”. This sentence is repetitive.
6. What is meaning of irregular split?
7. Line 84, elaborate FPKM.
8. Section 2.6, Is lncRNA expression in high and low expression groups significant or not? What
is the p-value?
9. Remove the repetitive sentences in discussion.
10. Be consistent with the wording, HCC or LIHC? carefully check for typos and grammatical
errors throughout the manuscript.
assistant