Reviewer's report
Title:Fatty liver index correlates with non-alcoholic fatty liver disease, but not
with newly diagnosed coronary artery atherosclerotic disease in Chinese patients
Version: 2Date:21 April 2013
Reviewer: Gianluca Perseghin
Reviewer's report:
I found little improvement in the revised version of the manuscript.
No efforts were performed by the authors to address the most critical issues
raised in the previous revision.
Major Compulsory Revisions
Point 1) I am sorry but I do believe you have to deal with this problem. As you
can easily realize based on your work it would result that diabetes is approaching
to be a protective factor for CAD based on your multivariate logistic regression
analyses of factors associated with CAD (OR in Table 4 is 0.4 in men (0.2-0.9)
and 0.6 (0.2-1.6) in women). This is obviously a bias related to the cross
sectional nature of the study. My feeling is that drug therapy is behind this
anomalous finding. You need to find a way to take into account for drug therapy.
You realize that the set of data shown as it is in the manuscript in your last
version does not represent a good service for the potential readers of the
manuscript.
Point 2) With this respect you have to put more efforts in listing the potential
factors; your duty is to drive the reader through your manuscript explaining what
might be missing with the cross sectional approach (duration of the disease, sex,
drug therapy, duration of drug assumption and so on) not simply to emphasize
that the cross sectional approach might be hiding something; you have to state
what ?
Point 3) OK
Point 4) OK
Point 5) This is a shame
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Fatty liver index correlates with non-alcoholic fatty liver disease, but not
with newly diagnosed coronary artery atherosclerotic disease in Chinese patients
Version: 2Date:21 April 2013
Reviewer: Gianluca Perseghin
Reviewer's report:
I found little improvement in the revised version of the manuscript.
No efforts were performed by the authors to address the most critical issues
raised in the previous revision.
Major Compulsory Revisions
Point 1) I am sorry but I do believe you have to deal with this problem. As you
can easily realize based on your work it would result that diabetes is approaching
to be a protective factor for CAD based on your multivariate logistic regression
analyses of factors associated with CAD (OR in Table 4 is 0.4 in men (0.2-0.9)
and 0.6 (0.2-1.6) in women). This is obviously a bias related to the cross
sectional nature of the study. My feeling is that drug therapy is behind this
anomalous finding. You need to find a way to take into account for drug therapy.
You realize that the set of data shown as it is in the manuscript in your last
version does not represent a good service for the potential readers of the
manuscript.
Point 2) With this respect you have to put more efforts in listing the potential
factors; your duty is to drive the reader through your manuscript explaining what
might be missing with the cross sectional approach (duration of the disease, sex,
drug therapy, duration of drug assumption and so on) not simply to emphasize
that the cross sectional approach might be hiding something; you have to state
what ?
Point 3) OK
Point 4) OK
Point 5) This is a shame
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Fatty liver index correlates with non-alcoholic fatty liver disease, but not
with newly diagnosed coronary artery atherosclerotic disease in Chinese patients
Version: 2Date:21 April 2013
Reviewer: Gianluca Perseghin
Reviewer's report:
I found little improvement in the revised version of the manuscript.
No efforts were performed by the authors to address the most critical issues
raised in the previous revision.
Major Compulsory Revisions
Point 1) I am sorry but I do believe you have to deal with this problem. As you
can easily realize based on your work it would result that diabetes is approaching
to be a protective factor for CAD based on your multivariate logistic regression
analyses of factors associated with CAD (OR in Table 4 is 0.4 in men (0.2-0.9)
and 0.6 (0.2-1.6) in women). This is obviously a bias related to the cross
sectional nature of the study. My feeling is that drug therapy is behind this
anomalous finding. You need to find a way to take into account for drug therapy.
You realize that the set of data shown as it is in the manuscript in your last
version does not represent a good service for the potential readers of the
manuscript.
Point 2) With this respect you have to put more efforts in listing the potential
factors; your duty is to drive the reader through your manuscript explaining what
might be missing with the cross sectional approach (duration of the disease, sex,
drug therapy, duration of drug assumption and so on) not simply to emphasize
that the cross sectional approach might be hiding something; you have to state
what ?
Point 3) OK
Point 4) OK
Point 5) This is a shame
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
assistant