Title: Perioperative risk factors for survival outcomes in elective colorectal cancer surgery: A
retrospective cohort study
Version: 6 Date: 30 Mar 2021
Reviewer:  Dario Parini
Reviewer's report:
Dear Authors,
I really appreciated to read your study and to have the possibility to review it.
Is very interesting to read about relation between inflammation status, inhalation anesthesia and
survival outcomes.
I have some considerations to submit to you:
1. In your analysis, you didn’t consider, between risk factors for long-term survival, surgical
complications, above all anastomotic leak, that is known to worse oncologic outcomes.
2. Similarly, you didn’t consider adjuvant chemotherapy, an other important factor in
determining long-term oncologic outcomes.
3. An other factor that you didn’t analyze is budding, an histological characteristic more and
more important in predict oncologic outcomes.
Would you be able to add these 3 factors in your statistical analysis? Anastomotic leak, in
particular, is a peri-operative risk factor that I think has to be considered
4. Why did you use Inflammation Prognostic Score (IPS) as inflammation grading and not other
scores, for example Glasgow Prognostic Score (GPS), a validated and easier to calculate score?
5. When you consider inflammatory cell response, you use Klintrup–Makinen score: is this
grading system the most diffused? Could you add references about that?
Thanks for the answers you will be able to give
Title: Perioperative risk factors for survival outcomes in elective colorectal cancer surgery: A
retrospective cohort study
Version: 6 Date: 30 Mar 2021
Reviewer:  Dario Parini
Reviewer's report:
Dear Authors,
I really appreciated to read your study and to have the possibility to review it.
Is very interesting to read about relation between inflammation status, inhalation anesthesia and
survival outcomes.
I have some considerations to submit to you:
1. In your analysis, you didn’t consider, between risk factors for long-term survival, surgical
complications, above all anastomotic leak, that is known to worse oncologic outcomes.
2. Similarly, you didn’t consider adjuvant chemotherapy, an other important factor in
determining long-term oncologic outcomes.
3. An other factor that you didn’t analyze is budding, an histological characteristic more and
more important in predict oncologic outcomes.
Would you be able to add these 3 factors in your statistical analysis? Anastomotic leak, in
particular, is a peri-operative risk factor that I think has to be considered
4. Why did you use Inflammation Prognostic Score (IPS) as inflammation grading and not other
scores, for example Glasgow Prognostic Score (GPS), a validated and easier to calculate score?
5. When you consider inflammatory cell response, you use Klintrup–Makinen score: is this
grading system the most diffused? Could you add references about that?
Thanks for the answers you will be able to give
Please review this paper.
user
Title: Perioperative risk factors for survival outcomes in elective colorectal cancer surgery: A
retrospective cohort study
Version: 6 Date: 30 Mar 2021
Reviewer:  Dario Parini
Reviewer's report:
Dear Authors,
I really appreciated to read your study and to have the possibility to review it.
Is very interesting to read about relation between inflammation status, inhalation anesthesia and
survival outcomes.
I have some considerations to submit to you:
1. In your analysis, you didn’t consider, between risk factors for long-term survival, surgical
complications, above all anastomotic leak, that is known to worse oncologic outcomes.
2. Similarly, you didn’t consider adjuvant chemotherapy, an other important factor in
determining long-term oncologic outcomes.
3. An other factor that you didn’t analyze is budding, an histological characteristic more and
more important in predict oncologic outcomes.
Would you be able to add these 3 factors in your statistical analysis? Anastomotic leak, in
particular, is a peri-operative risk factor that I think has to be considered
4. Why did you use Inflammation Prognostic Score (IPS) as inflammation grading and not other
scores, for example Glasgow Prognostic Score (GPS), a validated and easier to calculate score?
5. When you consider inflammatory cell response, you use Klintrup–Makinen score: is this
grading system the most diffused? Could you add references about that?
Thanks for the answers you will be able to give
assistant