Reviewer's report
Title:Gluten sensitivity enteropathy and recurrent aphthous stomatitis
Version: 6Date:4 March 2009
Reviewer: Julio C Bai
Reviewer's report:
The manuscript has been improved including most of the changes suggested by
the reviwers. In my opinion, the response from the authors to my main concern
(the possibility of a higher prevalence of a seronegative gluten sensitive
enteropathy) seems to be pertinent. However, this does not exclude the fact that
seronegative enteropathy are also gluten sensitive. In such event, response
(clinical and histological) to the GFD sould be confirmatory. What´s about clinical
improvement with GFD despite no serological or histological evidences of glten
sensitivity. Please, remember that 1/3 of patients with DH neither histological
damage nor positive serology tests. The authors should postulate potential
factors explaining discrepancies in prevalence among studies. Therefore, I
believe the manuscript could be viable just adding comments about this topics in
the discussion section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interest
Reviewer's report
Title:Gluten sensitivity enteropathy and recurrent aphthous stomatitis
Version: 6Date:4 March 2009
Reviewer: Julio C Bai
Reviewer's report:
The manuscript has been improved including most of the changes suggested by
the reviwers. In my opinion, the response from the authors to my main concern
(the possibility of a higher prevalence of a seronegative gluten sensitive
enteropathy) seems to be pertinent. However, this does not exclude the fact that
seronegative enteropathy are also gluten sensitive. In such event, response
(clinical and histological) to the GFD sould be confirmatory. What´s about clinical
improvement with GFD despite no serological or histological evidences of glten
sensitivity. Please, remember that 1/3 of patients with DH neither histological
damage nor positive serology tests. The authors should postulate potential
factors explaining discrepancies in prevalence among studies. Therefore, I
believe the manuscript could be viable just adding comments about this topics in
the discussion section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interest
Please review this paper.
user
Reviewer's report
Title:Gluten sensitivity enteropathy and recurrent aphthous stomatitis
Version: 6Date:4 March 2009
Reviewer: Julio C Bai
Reviewer's report:
The manuscript has been improved including most of the changes suggested by
the reviwers. In my opinion, the response from the authors to my main concern
(the possibility of a higher prevalence of a seronegative gluten sensitive
enteropathy) seems to be pertinent. However, this does not exclude the fact that
seronegative enteropathy are also gluten sensitive. In such event, response
(clinical and histological) to the GFD sould be confirmatory. What´s about clinical
improvement with GFD despite no serological or histological evidences of glten
sensitivity. Please, remember that 1/3 of patients with DH neither histological
damage nor positive serology tests. The authors should postulate potential
factors explaining discrepancies in prevalence among studies. Therefore, I
believe the manuscript could be viable just adding comments about this topics in
the discussion section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interest
assistant