Reviewer's report
Title:Combined effect of regulatory polymorphisms on transcription of UGT1A1
as a cause of Gilbert syndrome
Version: 3Date:14 April 2010
Reviewer: Libor Vítek
Reviewer's report:
Minor comments:
The paper has improved substantially by addressing of all comments.
Nevertheless, since authors were not able to relate genotypes with serum
bilirubin levels, it should be steted at the end of paper taht further studies are
needed/planned to elucidate this relationship.
UG1A1 gene is not always written in italics (see e.g. p. 18)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
Reviewer's report
Title:Combined effect of regulatory polymorphisms on transcription of UGT1A1
as a cause of Gilbert syndrome
Version: 3Date:14 April 2010
Reviewer: Libor Vítek
Reviewer's report:
Minor comments:
The paper has improved substantially by addressing of all comments.
Nevertheless, since authors were not able to relate genotypes with serum
bilirubin levels, it should be steted at the end of paper taht further studies are
needed/planned to elucidate this relationship.
UG1A1 gene is not always written in italics (see e.g. p. 18)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Combined effect of regulatory polymorphisms on transcription of UGT1A1
as a cause of Gilbert syndrome
Version: 3Date:14 April 2010
Reviewer: Libor Vítek
Reviewer's report:
Minor comments:
The paper has improved substantially by addressing of all comments.
Nevertheless, since authors were not able to relate genotypes with serum
bilirubin levels, it should be steted at the end of paper taht further studies are
needed/planned to elucidate this relationship.
UG1A1 gene is not always written in italics (see e.g. p. 18)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
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