Title: Effect of L-carnitine Supplementation on Muscle Cramps in Liver Cirrhosis: Results from
a Retrospective Cohort Study
Version: 2 Date: 11 Jan 2025
Reviewer's report:
Thank you for your response to the comments.
Absence of baseline data like 1.disease severity (CTP/ MELD scores) 2. Nutritional status 3.
severity of sarcopenia makes it difficult to conclude if these are potential confounding factors
for response to L carnitine supplementation.
Perhaps the authors in their conclusion can add a note that this is a pilot study and results of
this study should be validated with a well designed prospective study to avoid all biases and
confounders.
Title: Effect of L-carnitine Supplementation on Muscle Cramps in Liver Cirrhosis: Results from
a Retrospective Cohort Study
Version: 2 Date: 11 Jan 2025
Reviewer's report:
Thank you for your response to the comments.
Absence of baseline data like 1.disease severity (CTP/ MELD scores) 2. Nutritional status 3.
severity of sarcopenia makes it difficult to conclude if these are potential confounding factors
for response to L carnitine supplementation.
Perhaps the authors in their conclusion can add a note that this is a pilot study and results of
this study should be validated with a well designed prospective study to avoid all biases and
confounders.
Please review this paper.
user
Title: Effect of L-carnitine Supplementation on Muscle Cramps in Liver Cirrhosis: Results from
a Retrospective Cohort Study
Version: 2 Date: 11 Jan 2025
Reviewer's report:
Thank you for your response to the comments.
Absence of baseline data like 1.disease severity (CTP/ MELD scores) 2. Nutritional status 3.
severity of sarcopenia makes it difficult to conclude if these are potential confounding factors
for response to L carnitine supplementation.
Perhaps the authors in their conclusion can add a note that this is a pilot study and results of
this study should be validated with a well designed prospective study to avoid all biases and
confounders.
assistant