Reviewer's report
Title:Association of an NF-kappaB1 intron SNP (rs4648068) with gastric cancer
patients in Chinese Han population
Version: 2Date:21 December 2011
Reviewer: Joanne M Bowen
Reviewer's report:
I am grateful for the opportunity to review this manuscript. The authors describe a
case control study investigating the relationship between an NFKB1
polymorphism and risk of gastric cancer. In addition, the association between this
polymorphism and clinicopathologic variables was assessed.
Major Compulsory Revisions
Results: Patient characteristics of the cancer vs control patients are not shown.
Please include a table of age and sex demographics, and an evaluation of
balance between groups.
Minor Essential Revisions
Throughout the manuscript (including the title) the authors refer to their gene of
interest using the protein name, NF-#B 1. All references to the gene should be as
NFKB1 (italicised).
The manuscript contains editing errors related to; spacing, gene names not
shown in italics and inconsistent presentation of protein names.
Background section, paragraph 3. Please remove the results of the pilot
genotyping study from this section, since this is repetitive of what is covered in
the results section.
Methods section, paragraph 2. MJ Research have “Opticon” thermal cyclers, not
“Option”. Please check correct name of instrumentation.
Methods section, paragraph 3. The statistical analysis description lacks sufficient
detail to determine which measures were applied to each analysis.
Results section, paragraph 2. Change extron to exon
Results section, paragraph 4. Change from (Table 4) to (Table 3)
Discretionary Revisions
Include 3 – 10 keywords
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Association of an NF-kappaB1 intron SNP (rs4648068) with gastric cancer
patients in Chinese Han population
Version: 2Date:21 December 2011
Reviewer: Joanne M Bowen
Reviewer's report:
I am grateful for the opportunity to review this manuscript. The authors describe a
case control study investigating the relationship between an NFKB1
polymorphism and risk of gastric cancer. In addition, the association between this
polymorphism and clinicopathologic variables was assessed.
Major Compulsory Revisions
Results: Patient characteristics of the cancer vs control patients are not shown.
Please include a table of age and sex demographics, and an evaluation of
balance between groups.
Minor Essential Revisions
Throughout the manuscript (including the title) the authors refer to their gene of
interest using the protein name, NF-#B 1. All references to the gene should be as
NFKB1 (italicised).
The manuscript contains editing errors related to; spacing, gene names not
shown in italics and inconsistent presentation of protein names.
Background section, paragraph 3. Please remove the results of the pilot
genotyping study from this section, since this is repetitive of what is covered in
the results section.
Methods section, paragraph 2. MJ Research have “Opticon” thermal cyclers, not
“Option”. Please check correct name of instrumentation.
Methods section, paragraph 3. The statistical analysis description lacks sufficient
detail to determine which measures were applied to each analysis.
Results section, paragraph 2. Change extron to exon
Results section, paragraph 4. Change from (Table 4) to (Table 3)
Discretionary Revisions
Include 3 – 10 keywords
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Association of an NF-kappaB1 intron SNP (rs4648068) with gastric cancer
patients in Chinese Han population
Version: 2Date:21 December 2011
Reviewer: Joanne M Bowen
Reviewer's report:
I am grateful for the opportunity to review this manuscript. The authors describe a
case control study investigating the relationship between an NFKB1
polymorphism and risk of gastric cancer. In addition, the association between this
polymorphism and clinicopathologic variables was assessed.
Major Compulsory Revisions
Results: Patient characteristics of the cancer vs control patients are not shown.
Please include a table of age and sex demographics, and an evaluation of
balance between groups.
Minor Essential Revisions
Throughout the manuscript (including the title) the authors refer to their gene of
interest using the protein name, NF-#B 1. All references to the gene should be as
NFKB1 (italicised).
The manuscript contains editing errors related to; spacing, gene names not
shown in italics and inconsistent presentation of protein names.
Background section, paragraph 3. Please remove the results of the pilot
genotyping study from this section, since this is repetitive of what is covered in
the results section.
Methods section, paragraph 2. MJ Research have “Opticon” thermal cyclers, not
“Option”. Please check correct name of instrumentation.
Methods section, paragraph 3. The statistical analysis description lacks sufficient
detail to determine which measures were applied to each analysis.
Results section, paragraph 2. Change extron to exon
Results section, paragraph 4. Change from (Table 4) to (Table 3)
Discretionary Revisions
Include 3 – 10 keywords
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant