Title: Poly-#-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: An
experimental piglet study
Version: 1 Date: 06 Dec 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors present a very interesting research study using a scaffold
in order to improve the quality of the anastomosis in colorectal surgery. They present a case
series in animal model of the proposed scaffold. The study is correctly conduced respecting
ethical principles about animal wellness. The results are presented very well with completeness.
The findings are about the usefulness of a scaffold in order to improve the quality of colorectal
anastomosis. They experimented that the histologic findings prove that the quality of the
anastomosis is improved because of it impacts in the quality of the scar tissue around the
anastomosis itself that is quite reasonable due to the use of the scaffold. It is not usual to imagine
to use devices to improve anastomosis despite anastomosis leakage remains a major problem
in this surgical field. The results should be an important starting point for further studies and
evaluations.
Title: Poly-#-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: An
experimental piglet study
Version: 1 Date: 06 Dec 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors present a very interesting research study using a scaffold
in order to improve the quality of the anastomosis in colorectal surgery. They present a case
series in animal model of the proposed scaffold. The study is correctly conduced respecting
ethical principles about animal wellness. The results are presented very well with completeness.
The findings are about the usefulness of a scaffold in order to improve the quality of colorectal
anastomosis. They experimented that the histologic findings prove that the quality of the
anastomosis is improved because of it impacts in the quality of the scar tissue around the
anastomosis itself that is quite reasonable due to the use of the scaffold. It is not usual to imagine
to use devices to improve anastomosis despite anastomosis leakage remains a major problem
in this surgical field. The results should be an important starting point for further studies and
evaluations.
Please review this paper.
user
Title: Poly-#-caprolactone scaffold as staple-line reinforcement of rectal anastomosis: An
experimental piglet study
Version: 1 Date: 06 Dec 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors present a very interesting research study using a scaffold
in order to improve the quality of the anastomosis in colorectal surgery. They present a case
series in animal model of the proposed scaffold. The study is correctly conduced respecting
ethical principles about animal wellness. The results are presented very well with completeness.
The findings are about the usefulness of a scaffold in order to improve the quality of colorectal
anastomosis. They experimented that the histologic findings prove that the quality of the
anastomosis is improved because of it impacts in the quality of the scar tissue around the
anastomosis itself that is quite reasonable due to the use of the scaffold. It is not usual to imagine
to use devices to improve anastomosis despite anastomosis leakage remains a major problem
in this surgical field. The results should be an important starting point for further studies and
evaluations.
assistant