Reviewer's report
Title:Derangements of Liver Tissue Bioenergetics in Concanavalin A-Induced
Hepatitis
Version: 2Date:13 September 2012
Reviewer: Dechun Feng
Reviewer's report:
In this study, the authors reported an interesting finding that O2 consumption in
the liver was increased after ConA injection. The increased O2 consumption in
the liver may be attribute to the elevation of serum IFN-gamma levels but not
increased infiltration of lymphocytes as suggested.
Major Compulsory Revisions:
ConA injection may increase many cytokines expression such as IL-6,
IFN-gamma, TNF-alpha , IL-4,IL-12 and so on. The authors observed reduced
O2 consumption in IFN-gamma KO mice after ConA injection and concluded that
IFN-gamma was the main reason for the increased O2 consumption. However,
more direct evidence should be provided such as treat the mice with exogenous
IFN-gamma or treat freshly isolated hepatocytes with IFN-gamma to see whether
O2 consumption will be altered.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Derangements of Liver Tissue Bioenergetics in Concanavalin A-Induced
Hepatitis
Version: 2Date:13 September 2012
Reviewer: Dechun Feng
Reviewer's report:
In this study, the authors reported an interesting finding that O2 consumption in
the liver was increased after ConA injection. The increased O2 consumption in
the liver may be attribute to the elevation of serum IFN-gamma levels but not
increased infiltration of lymphocytes as suggested.
Major Compulsory Revisions:
ConA injection may increase many cytokines expression such as IL-6,
IFN-gamma, TNF-alpha , IL-4,IL-12 and so on. The authors observed reduced
O2 consumption in IFN-gamma KO mice after ConA injection and concluded that
IFN-gamma was the main reason for the increased O2 consumption. However,
more direct evidence should be provided such as treat the mice with exogenous
IFN-gamma or treat freshly isolated hepatocytes with IFN-gamma to see whether
O2 consumption will be altered.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Derangements of Liver Tissue Bioenergetics in Concanavalin A-Induced
Hepatitis
Version: 2Date:13 September 2012
Reviewer: Dechun Feng
Reviewer's report:
In this study, the authors reported an interesting finding that O2 consumption in
the liver was increased after ConA injection. The increased O2 consumption in
the liver may be attribute to the elevation of serum IFN-gamma levels but not
increased infiltration of lymphocytes as suggested.
Major Compulsory Revisions:
ConA injection may increase many cytokines expression such as IL-6,
IFN-gamma, TNF-alpha , IL-4,IL-12 and so on. The authors observed reduced
O2 consumption in IFN-gamma KO mice after ConA injection and concluded that
IFN-gamma was the main reason for the increased O2 consumption. However,
more direct evidence should be provided such as treat the mice with exogenous
IFN-gamma or treat freshly isolated hepatocytes with IFN-gamma to see whether
O2 consumption will be altered.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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