Title: Incidence and Risk factors of Fasting Hyperglycaemia Following First-attack Acute
Pancreatitis Before Discharge: A Retrospective Study
Version: 1 Date: 07 Nov 2022
Reviewer's report:
Dear Editor,
The current study entitled “Incidence and Risk factors of Fasting Hyperglycemia Following
First-Attack Acute Pancreatitis: A Retrospective Study” analysed risk factors for developing
fasting hyperglycaemia in 311 individuals with first-attack acute pancreatitis in a single tertiary
centre in China. The authors identified that old age, high CTSI score, serum triglycerides, serum
total cholesterol, hypocalcaemia, and aetiology were associated with fasting hyperglycaemia.
Of these, age # 60 years old and TG # 5.65 mmol/L were independent risk factors for fasting
hyperglycaemia following first-attack acute pancreatitis. This study is interesting. I have the
following comments:
1. How hyperlipidaemia-associated acute pancreatitis was defined? Since TG #5.65mmol/L was
an independent risk factor for fasting hyperglycaemia, but why not hyperlipidaemia aetiology?
2. What are the basic comorbidity status (e.g. fatty liver diseases) of the included patients?
3. The study is poorly written with many of important papers missing in the introduction and
discussion.
For stress hyperglycaemia:
Stress hyperglycemia is independently associated with persistent organ failure in acute
pancreatitis. Dig Dis Sci. 2022 May;67(5):1879-1889.
Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute
pancreatitis. Front Endocrinol (Lausanne). 2022 Oct 7;13:998499.
For diabetes following acute pancreatitis:
Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic
Review and Meta-Analysis. Front Physiol. 2019 May 31;10:637.
Diabetes following acute pancreatitis. Lancet Gastroenterol Hepatol. 2021 Aug;6(8):668-675.
Title: Incidence and Risk factors of Fasting Hyperglycaemia Following First-attack Acute
Pancreatitis Before Discharge: A Retrospective Study
Version: 1 Date: 07 Nov 2022
Reviewer's report:
Dear Editor,
The current study entitled “Incidence and Risk factors of Fasting Hyperglycemia Following
First-Attack Acute Pancreatitis: A Retrospective Study” analysed risk factors for developing
fasting hyperglycaemia in 311 individuals with first-attack acute pancreatitis in a single tertiary
centre in China. The authors identified that old age, high CTSI score, serum triglycerides, serum
total cholesterol, hypocalcaemia, and aetiology were associated with fasting hyperglycaemia.
Of these, age # 60 years old and TG # 5.65 mmol/L were independent risk factors for fasting
hyperglycaemia following first-attack acute pancreatitis. This study is interesting. I have the
following comments:
1. How hyperlipidaemia-associated acute pancreatitis was defined? Since TG #5.65mmol/L was
an independent risk factor for fasting hyperglycaemia, but why not hyperlipidaemia aetiology?
2. What are the basic comorbidity status (e.g. fatty liver diseases) of the included patients?
3. The study is poorly written with many of important papers missing in the introduction and
discussion.
For stress hyperglycaemia:
Stress hyperglycemia is independently associated with persistent organ failure in acute
pancreatitis. Dig Dis Sci. 2022 May;67(5):1879-1889.
Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute
pancreatitis. Front Endocrinol (Lausanne). 2022 Oct 7;13:998499.
For diabetes following acute pancreatitis:
Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic
Review and Meta-Analysis. Front Physiol. 2019 May 31;10:637.
Diabetes following acute pancreatitis. Lancet Gastroenterol Hepatol. 2021 Aug;6(8):668-675.
Please review this paper.
user
Title: Incidence and Risk factors of Fasting Hyperglycaemia Following First-attack Acute
Pancreatitis Before Discharge: A Retrospective Study
Version: 1 Date: 07 Nov 2022
Reviewer's report:
Dear Editor,
The current study entitled “Incidence and Risk factors of Fasting Hyperglycemia Following
First-Attack Acute Pancreatitis: A Retrospective Study” analysed risk factors for developing
fasting hyperglycaemia in 311 individuals with first-attack acute pancreatitis in a single tertiary
centre in China. The authors identified that old age, high CTSI score, serum triglycerides, serum
total cholesterol, hypocalcaemia, and aetiology were associated with fasting hyperglycaemia.
Of these, age # 60 years old and TG # 5.65 mmol/L were independent risk factors for fasting
hyperglycaemia following first-attack acute pancreatitis. This study is interesting. I have the
following comments:
1. How hyperlipidaemia-associated acute pancreatitis was defined? Since TG #5.65mmol/L was
an independent risk factor for fasting hyperglycaemia, but why not hyperlipidaemia aetiology?
2. What are the basic comorbidity status (e.g. fatty liver diseases) of the included patients?
3. The study is poorly written with many of important papers missing in the introduction and
discussion.
For stress hyperglycaemia:
Stress hyperglycemia is independently associated with persistent organ failure in acute
pancreatitis. Dig Dis Sci. 2022 May;67(5):1879-1889.
Impact of admission and early persistent stress hyperglycaemia on clinical outcomes in acute
pancreatitis. Front Endocrinol (Lausanne). 2022 Oct 7;13:998499.
For diabetes following acute pancreatitis:
Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis: A Systematic
Review and Meta-Analysis. Front Physiol. 2019 May 31;10:637.
Diabetes following acute pancreatitis. Lancet Gastroenterol Hepatol. 2021 Aug;6(8):668-675.
assistant