Title: Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in
central Iran
Version: 1 Date: 10 Jan 2021
Reviewer:  Yuqing Liu
Reviewer's report:
The present study is the first to report on the frequency of salmonellosis and its associated
resistance patterns for a panel of 16 antibiotics in central Iran. The conclusion is quite regionally
outstanding. High rates of quinolone resistance and low frequency of MDR in Salmonella spp.
were found to be prevalent in central Iran and other parts of Asia#maybe because the traditional
first-line drugs used to treat Salmonella spp. are chloramphenicol, ampicillin, and cotrimoxazole.
Empiric antibiotic therapy should surely be adapted by Uniform rotation of prescribed antibiotics
of AST susceptible to save more children.
Out of 230 samples of infectious diarrhea, 21 (9.1%) cases of Salmonella spp. were identified
using culture methods. Another 28 (12.1%) samples had positive PCR results, with S. serovar
Paratyphi B and C (9/21; 42.8%) and S. Typhi (3/21; 14.3%) being the most recognized. The
expression is not clear
Title: Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in
central Iran
Version: 1 Date: 10 Jan 2021
Reviewer:  Yuqing Liu
Reviewer's report:
The present study is the first to report on the frequency of salmonellosis and its associated
resistance patterns for a panel of 16 antibiotics in central Iran. The conclusion is quite regionally
outstanding. High rates of quinolone resistance and low frequency of MDR in Salmonella spp.
were found to be prevalent in central Iran and other parts of Asia#maybe because the traditional
first-line drugs used to treat Salmonella spp. are chloramphenicol, ampicillin, and cotrimoxazole.
Empiric antibiotic therapy should surely be adapted by Uniform rotation of prescribed antibiotics
of AST susceptible to save more children.
Out of 230 samples of infectious diarrhea, 21 (9.1%) cases of Salmonella spp. were identified
using culture methods. Another 28 (12.1%) samples had positive PCR results, with S. serovar
Paratyphi B and C (9/21; 42.8%) and S. Typhi (3/21; 14.3%) being the most recognized. The
expression is not clear
Please review this paper.
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Title: Quinolone resistant Salmonella species isolated from pediatric patients with diarrhea in
central Iran
Version: 1 Date: 10 Jan 2021
Reviewer:  Yuqing Liu
Reviewer's report:
The present study is the first to report on the frequency of salmonellosis and its associated
resistance patterns for a panel of 16 antibiotics in central Iran. The conclusion is quite regionally
outstanding. High rates of quinolone resistance and low frequency of MDR in Salmonella spp.
were found to be prevalent in central Iran and other parts of Asia#maybe because the traditional
first-line drugs used to treat Salmonella spp. are chloramphenicol, ampicillin, and cotrimoxazole.
Empiric antibiotic therapy should surely be adapted by Uniform rotation of prescribed antibiotics
of AST susceptible to save more children.
Out of 230 samples of infectious diarrhea, 21 (9.1%) cases of Salmonella spp. were identified
using culture methods. Another 28 (12.1%) samples had positive PCR results, with S. serovar
Paratyphi B and C (9/21; 42.8%) and S. Typhi (3/21; 14.3%) being the most recognized. The
expression is not clear
assistant