Title: Ultrasound-Derived Fat Fraction: A Novel Approach for Assessing Wilson's Disease-
Related Hepatic Steatosis
Version: 1 Date: 11 Mar 2025
Reviewer's report:
This study aimed to evaluate the clinical utility and measurement consistency of ultrasound-
derived fat fraction (UDFF) in assessing hepatic steatosis in patients with Wilson’s disease
(WD).
While the study explores an important topic and provides interesting insights into the application
of UDFF in WD, the use of the Hamaguchi score (a qualitative and operator-dependent
method with limited reproducibility) as the reference standard for diagnosing hepatic steatosis
is unacceptable.
Title: Ultrasound-Derived Fat Fraction: A Novel Approach for Assessing Wilson's Disease-
Related Hepatic Steatosis
Version: 1 Date: 11 Mar 2025
Reviewer's report:
This study aimed to evaluate the clinical utility and measurement consistency of ultrasound-
derived fat fraction (UDFF) in assessing hepatic steatosis in patients with Wilson’s disease
(WD).
While the study explores an important topic and provides interesting insights into the application
of UDFF in WD, the use of the Hamaguchi score (a qualitative and operator-dependent
method with limited reproducibility) as the reference standard for diagnosing hepatic steatosis
is unacceptable.
Please review this paper.
user
Title: Ultrasound-Derived Fat Fraction: A Novel Approach for Assessing Wilson's Disease-
Related Hepatic Steatosis
Version: 1 Date: 11 Mar 2025
Reviewer's report:
This study aimed to evaluate the clinical utility and measurement consistency of ultrasound-
derived fat fraction (UDFF) in assessing hepatic steatosis in patients with Wilson’s disease
(WD).
While the study explores an important topic and provides interesting insights into the application
of UDFF in WD, the use of the Hamaguchi score (a qualitative and operator-dependent
method with limited reproducibility) as the reference standard for diagnosing hepatic steatosis
is unacceptable.
assistant