Title: A Systems Biology Approach to Pathogenesis of Gastric Cancer: Gene Network Modeling
and Pathway Analysis
Version: 0 Date: 04 May 2023
Reviewer's report:
1. Use same format for mentioning the version in the whole manuscript, ex. Ver, version,
Version.
2. Rewrite sentence - side heading, Reconstruction .... analysis : "Four computational algor...
as hub genes".
3. In figure 1 and 2 explanation has "previous studies using", is it published anywhere or what?
4. In table 2, use comma or semicolon for separating the other names.
5. Combine figure 3, 4 and 5 as a single figure, follow the enclosed reference article.
6. Do not use any software or tool address repeatedly, ex. string in many places.
7. Correct whether biological function or molecular function.
8. What is the valid output for motif analysis result?
9. Discussion part should be needed extensive editing: Do not include too much available others
information, discuss only your output with other reference, is there any similar result predicted
when comparing with other GC articles. There are so many research articles available for GC.
Reference Article:
Chinnappan J, Ramu A, V VR, S AK. Integrative Bioinformatics approaches to therapeutic gene
target selection in various cancers for Nitroglycerin. Sci Rep. 2021 Nov 11;11(1):22036. doi:
10.1038/s41598-021-01508-8. PMID: 34764329; PMCID: PMC8586365.
Title: A Systems Biology Approach to Pathogenesis of Gastric Cancer: Gene Network Modeling
and Pathway Analysis
Version: 0 Date: 04 May 2023
Reviewer's report:
1. Use same format for mentioning the version in the whole manuscript, ex. Ver, version,
Version.
2. Rewrite sentence - side heading, Reconstruction .... analysis : "Four computational algor...
as hub genes".
3. In figure 1 and 2 explanation has "previous studies using", is it published anywhere or what?
4. In table 2, use comma or semicolon for separating the other names.
5. Combine figure 3, 4 and 5 as a single figure, follow the enclosed reference article.
6. Do not use any software or tool address repeatedly, ex. string in many places.
7. Correct whether biological function or molecular function.
8. What is the valid output for motif analysis result?
9. Discussion part should be needed extensive editing: Do not include too much available others
information, discuss only your output with other reference, is there any similar result predicted
when comparing with other GC articles. There are so many research articles available for GC.
Reference Article:
Chinnappan J, Ramu A, V VR, S AK. Integrative Bioinformatics approaches to therapeutic gene
target selection in various cancers for Nitroglycerin. Sci Rep. 2021 Nov 11;11(1):22036. doi:
10.1038/s41598-021-01508-8. PMID: 34764329; PMCID: PMC8586365.
Please review this paper.
user
Title: A Systems Biology Approach to Pathogenesis of Gastric Cancer: Gene Network Modeling
and Pathway Analysis
Version: 0 Date: 04 May 2023
Reviewer's report:
1. Use same format for mentioning the version in the whole manuscript, ex. Ver, version,
Version.
2. Rewrite sentence - side heading, Reconstruction .... analysis : "Four computational algor...
as hub genes".
3. In figure 1 and 2 explanation has "previous studies using", is it published anywhere or what?
4. In table 2, use comma or semicolon for separating the other names.
5. Combine figure 3, 4 and 5 as a single figure, follow the enclosed reference article.
6. Do not use any software or tool address repeatedly, ex. string in many places.
7. Correct whether biological function or molecular function.
8. What is the valid output for motif analysis result?
9. Discussion part should be needed extensive editing: Do not include too much available others
information, discuss only your output with other reference, is there any similar result predicted
when comparing with other GC articles. There are so many research articles available for GC.
Reference Article:
Chinnappan J, Ramu A, V VR, S AK. Integrative Bioinformatics approaches to therapeutic gene
target selection in various cancers for Nitroglycerin. Sci Rep. 2021 Nov 11;11(1):22036. doi:
10.1038/s41598-021-01508-8. PMID: 34764329; PMCID: PMC8586365.
assistant