Reviewer's report
Title:Differential detection of nuclear envelope autoantibodies in primary biliary
cirrhosis using routine and alternative methods
Version: 1Date:7 January 2010
Reviewer: Alessandro Granito
Reviewer's report:
Major points
- The study is clear presented and results are adequately discussed. The new
methodology presented by the authors seem to offer a gain of sensitivity of
Rim-like ANA pattern. I think it should be included a number of healthy and
pathological controls to verify the specificity of autoantibodies searched by the
new method.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Differential detection of nuclear envelope autoantibodies in primary biliary
cirrhosis using routine and alternative methods
Version: 1Date:7 January 2010
Reviewer: Alessandro Granito
Reviewer's report:
Major points
- The study is clear presented and results are adequately discussed. The new
methodology presented by the authors seem to offer a gain of sensitivity of
Rim-like ANA pattern. I think it should be included a number of healthy and
pathological controls to verify the specificity of autoantibodies searched by the
new method.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Differential detection of nuclear envelope autoantibodies in primary biliary
cirrhosis using routine and alternative methods
Version: 1Date:7 January 2010
Reviewer: Alessandro Granito
Reviewer's report:
Major points
- The study is clear presented and results are adequately discussed. The new
methodology presented by the authors seem to offer a gain of sensitivity of
Rim-like ANA pattern. I think it should be included a number of healthy and
pathological controls to verify the specificity of autoantibodies searched by the
new method.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
'I declare that I have no competing interests'
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