Reviewer's report
Title:Treatment of children and adolescents with ulcerative colitis by adsorptive
depletion of myeloid lineage leucocytes as monotherapy or in combination with
low dose prednisolone after failure of first-line medications
Version: 3Date:16 July 2013
Reviewer: Jennifer deBruyn
Reviewer's report:
Thank you for the opportunity to review the revised manuscript by Tanaka et al.
The authors have adequately addressed the majority of comments.
I also suggest future use of more widely-used disease activity and endoscopic
indices, such as the PUCAI and Mayo endoscopic score.
Minor essential revisions:
1. There is a discrepancy in enrolment period. The abstract states that subjects
participated between 2010 and 2012 whereas the methods section indicates the
trial period between 2000 and 2012. Please clarify.
2. All acronyms should be defined prior to their use. What is CE? (Methods: GMA
procedures)
3. Correct grammar and spelling errors in ‘Treatment safety, feasibility, and
patients’ compliance”
4. Categorize Table 1 by patient response (to salicylates alone, GMA alone, or
GMA and prednisolone). This helps the reader identify the baseline
demographics of each class of patients. Alternatively, the data can also be
presented differently in Table 1 to improve it’s readability: Ie, Column titles:
Salicylate alone, GMA alone, GMA and prednisolone. Rows would read: Gender
(M/F) n (%), Age (mean or median with standard deviation or range), weight
(mean or median with standard deviation or range), baseline medication (mean
or median with standard deviation or range), location of UC, n (%), duration of
UC (mean or median with standard deviation or range), CAI (mean or median
with standard deviation or range), DAI (mean or median with standard deviation
or range).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Treatment of children and adolescents with ulcerative colitis by adsorptive
depletion of myeloid lineage leucocytes as monotherapy or in combination with
low dose prednisolone after failure of first-line medications
Version: 3Date:16 July 2013
Reviewer: Jennifer deBruyn
Reviewer's report:
Thank you for the opportunity to review the revised manuscript by Tanaka et al.
The authors have adequately addressed the majority of comments.
I also suggest future use of more widely-used disease activity and endoscopic
indices, such as the PUCAI and Mayo endoscopic score.
Minor essential revisions:
1. There is a discrepancy in enrolment period. The abstract states that subjects
participated between 2010 and 2012 whereas the methods section indicates the
trial period between 2000 and 2012. Please clarify.
2. All acronyms should be defined prior to their use. What is CE? (Methods: GMA
procedures)
3. Correct grammar and spelling errors in ‘Treatment safety, feasibility, and
patients’ compliance”
4. Categorize Table 1 by patient response (to salicylates alone, GMA alone, or
GMA and prednisolone). This helps the reader identify the baseline
demographics of each class of patients. Alternatively, the data can also be
presented differently in Table 1 to improve it’s readability: Ie, Column titles:
Salicylate alone, GMA alone, GMA and prednisolone. Rows would read: Gender
(M/F) n (%), Age (mean or median with standard deviation or range), weight
(mean or median with standard deviation or range), baseline medication (mean
or median with standard deviation or range), location of UC, n (%), duration of
UC (mean or median with standard deviation or range), CAI (mean or median
with standard deviation or range), DAI (mean or median with standard deviation
or range).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Treatment of children and adolescents with ulcerative colitis by adsorptive
depletion of myeloid lineage leucocytes as monotherapy or in combination with
low dose prednisolone after failure of first-line medications
Version: 3Date:16 July 2013
Reviewer: Jennifer deBruyn
Reviewer's report:
Thank you for the opportunity to review the revised manuscript by Tanaka et al.
The authors have adequately addressed the majority of comments.
I also suggest future use of more widely-used disease activity and endoscopic
indices, such as the PUCAI and Mayo endoscopic score.
Minor essential revisions:
1. There is a discrepancy in enrolment period. The abstract states that subjects
participated between 2010 and 2012 whereas the methods section indicates the
trial period between 2000 and 2012. Please clarify.
2. All acronyms should be defined prior to their use. What is CE? (Methods: GMA
procedures)
3. Correct grammar and spelling errors in ‘Treatment safety, feasibility, and
patients’ compliance”
4. Categorize Table 1 by patient response (to salicylates alone, GMA alone, or
GMA and prednisolone). This helps the reader identify the baseline
demographics of each class of patients. Alternatively, the data can also be
presented differently in Table 1 to improve it’s readability: Ie, Column titles:
Salicylate alone, GMA alone, GMA and prednisolone. Rows would read: Gender
(M/F) n (%), Age (mean or median with standard deviation or range), weight
(mean or median with standard deviation or range), baseline medication (mean
or median with standard deviation or range), location of UC, n (%), duration of
UC (mean or median with standard deviation or range), CAI (mean or median
with standard deviation or range), DAI (mean or median with standard deviation
or range).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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