Title: Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing Enterocolitis:
A Retrospective Case-control Study
Version: 2 Date: 15 Mar 2022
Reviewer's report:
The paper titled "Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing
Enterocolitis: A Retrospective Case-control Study" has been reviewed. Although it is well
written, there are some  issues hat require revisions.
1. Title, abstract and keywords are adequate.  Authors may consider adding "inflammation" as
an additional keyword.
2. Introduction is too long, yet lacks adequate background data about  NLR.
NLR is a novel marker of inflammation derived from routine blood count test.
Its association with inflammation has been reported in inflammatory bowel disease
(Wiener klinische Wochenschrift (2015)127:262-265. DOI 10.1007/s00508-014-0683-5),
irritable bowel disease (Fam Med Prim Care Rev 2020; 22(2): 107–110. DOI: 10.5114/
fmpcr.2020.95311. ), diabetes mellitus type 2 (Aging Male, 2020;23(5):923-927. DOI:
10.1080/13685538.2019.1632283), thyroiditis (Rev Assoc Med Bras 2017; 63(12):1065-1068.
DOI: 10.1590/1806-9282.63.12.1065), and Covid-19 infection (Rev Assoc Med Bras
2021;67(Suppl 1):1-2. DOI: 10.1590/1806-9282.67.Suppl1.20200678.). All these conditions are
inflammatory processes alike with NEC. Background should be improved adequately.
3. Methods were expressed well and statistics are mostly accurate. However, normality analysis
of the study variables was not mentioned. Did authors conduct Kolmogorov-Smirnov or Shapiro
wilk test for this analysis?
4. Results presented systematically and Discussion is fair enough. Only # can suggest adding a
sentence or two about possible clinical utility of the study findings in discussion.
Overall, I recommend publication after suitably revised.
Title: Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing Enterocolitis:
A Retrospective Case-control Study
Version: 2 Date: 15 Mar 2022
Reviewer's report:
The paper titled "Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing
Enterocolitis: A Retrospective Case-control Study" has been reviewed. Although it is well
written, there are some  issues hat require revisions.
1. Title, abstract and keywords are adequate.  Authors may consider adding "inflammation" as
an additional keyword.
2. Introduction is too long, yet lacks adequate background data about  NLR.
NLR is a novel marker of inflammation derived from routine blood count test.
Its association with inflammation has been reported in inflammatory bowel disease
(Wiener klinische Wochenschrift (2015)127:262-265. DOI 10.1007/s00508-014-0683-5),
irritable bowel disease (Fam Med Prim Care Rev 2020; 22(2): 107–110. DOI: 10.5114/
fmpcr.2020.95311. ), diabetes mellitus type 2 (Aging Male, 2020;23(5):923-927. DOI:
10.1080/13685538.2019.1632283), thyroiditis (Rev Assoc Med Bras 2017; 63(12):1065-1068.
DOI: 10.1590/1806-9282.63.12.1065), and Covid-19 infection (Rev Assoc Med Bras
2021;67(Suppl 1):1-2. DOI: 10.1590/1806-9282.67.Suppl1.20200678.). All these conditions are
inflammatory processes alike with NEC. Background should be improved adequately.
3. Methods were expressed well and statistics are mostly accurate. However, normality analysis
of the study variables was not mentioned. Did authors conduct Kolmogorov-Smirnov or Shapiro
wilk test for this analysis?
4. Results presented systematically and Discussion is fair enough. Only # can suggest adding a
sentence or two about possible clinical utility of the study findings in discussion.
Overall, I recommend publication after suitably revised.
Please review this paper.
user
Title: Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing Enterocolitis:
A Retrospective Case-control Study
Version: 2 Date: 15 Mar 2022
Reviewer's report:
The paper titled "Association of Neutrophil to Lymphocyte Ratio with Preterm Necrotizing
Enterocolitis: A Retrospective Case-control Study" has been reviewed. Although it is well
written, there are some  issues hat require revisions.
1. Title, abstract and keywords are adequate.  Authors may consider adding "inflammation" as
an additional keyword.
2. Introduction is too long, yet lacks adequate background data about  NLR.
NLR is a novel marker of inflammation derived from routine blood count test.
Its association with inflammation has been reported in inflammatory bowel disease
(Wiener klinische Wochenschrift (2015)127:262-265. DOI 10.1007/s00508-014-0683-5),
irritable bowel disease (Fam Med Prim Care Rev 2020; 22(2): 107–110. DOI: 10.5114/
fmpcr.2020.95311. ), diabetes mellitus type 2 (Aging Male, 2020;23(5):923-927. DOI:
10.1080/13685538.2019.1632283), thyroiditis (Rev Assoc Med Bras 2017; 63(12):1065-1068.
DOI: 10.1590/1806-9282.63.12.1065), and Covid-19 infection (Rev Assoc Med Bras
2021;67(Suppl 1):1-2. DOI: 10.1590/1806-9282.67.Suppl1.20200678.). All these conditions are
inflammatory processes alike with NEC. Background should be improved adequately.
3. Methods were expressed well and statistics are mostly accurate. However, normality analysis
of the study variables was not mentioned. Did authors conduct Kolmogorov-Smirnov or Shapiro
wilk test for this analysis?
4. Results presented systematically and Discussion is fair enough. Only # can suggest adding a
sentence or two about possible clinical utility of the study findings in discussion.
Overall, I recommend publication after suitably revised.
assistant