Title: Study on the relationship of depression, anxiety, lifestyle and eating habits with the
severity of reflux esophagitis
Version: 4 Date: 03 Jan 2021
Reviewer's report:
This is a retrospective case-controlled study attempting to identify the risk factors or associated
factors of reflux esophagitis, including demographic data, lifestyle habits, eating habits,
depression, and anxiety. The study also tried to correlate the severity of reflux esophagitis and
the severity of anxiety and depression, as well as the severity of anxiety and depression with
patients’ quality of life.
Major comments:
1. Given the retrospective nature of this study, risk factors or causation cannot be determined.
May consider using the word “correlation or association or relationship” instead.
2. The timeline of when patients getting the diagnosis of reflux esophagitis and completing the
questionnaires should be mentioned in the study design.
3. Authors provided clear definitions of multiple measures. Please also clarify “sleeping on low
pillow.”
Minor comments:
1. There are multiple spacing, punctuation errors that should be corrected
2. Please correct “There were also significant differences in the relationship between smoking,
drinking alcohol, coffee and other lifestyles and RE similar to previous some of the previous
studies.”
3. Please expand h. (in 2.4 definitions section)
4. Please format citations and references per journal specifications.
Title: Study on the relationship of depression, anxiety, lifestyle and eating habits with the
severity of reflux esophagitis
Version: 4 Date: 03 Jan 2021
Reviewer's report:
This is a retrospective case-controlled study attempting to identify the risk factors or associated
factors of reflux esophagitis, including demographic data, lifestyle habits, eating habits,
depression, and anxiety. The study also tried to correlate the severity of reflux esophagitis and
the severity of anxiety and depression, as well as the severity of anxiety and depression with
patients’ quality of life.
Major comments:
1. Given the retrospective nature of this study, risk factors or causation cannot be determined.
May consider using the word “correlation or association or relationship” instead.
2. The timeline of when patients getting the diagnosis of reflux esophagitis and completing the
questionnaires should be mentioned in the study design.
3. Authors provided clear definitions of multiple measures. Please also clarify “sleeping on low
pillow.”
Minor comments:
1. There are multiple spacing, punctuation errors that should be corrected
2. Please correct “There were also significant differences in the relationship between smoking,
drinking alcohol, coffee and other lifestyles and RE similar to previous some of the previous
studies.”
3. Please expand h. (in 2.4 definitions section)
4. Please format citations and references per journal specifications.
Please review this paper.
user
Title: Study on the relationship of depression, anxiety, lifestyle and eating habits with the
severity of reflux esophagitis
Version: 4 Date: 03 Jan 2021
Reviewer's report:
This is a retrospective case-controlled study attempting to identify the risk factors or associated
factors of reflux esophagitis, including demographic data, lifestyle habits, eating habits,
depression, and anxiety. The study also tried to correlate the severity of reflux esophagitis and
the severity of anxiety and depression, as well as the severity of anxiety and depression with
patients’ quality of life.
Major comments:
1. Given the retrospective nature of this study, risk factors or causation cannot be determined.
May consider using the word “correlation or association or relationship” instead.
2. The timeline of when patients getting the diagnosis of reflux esophagitis and completing the
questionnaires should be mentioned in the study design.
3. Authors provided clear definitions of multiple measures. Please also clarify “sleeping on low
pillow.”
Minor comments:
1. There are multiple spacing, punctuation errors that should be corrected
2. Please correct “There were also significant differences in the relationship between smoking,
drinking alcohol, coffee and other lifestyles and RE similar to previous some of the previous
studies.”
3. Please expand h. (in 2.4 definitions section)
4. Please format citations and references per journal specifications.
assistant