Title: Inflammatory bowel disease increases the risk of pancreatitis: A two-sample bidirectional
mendelian randomization analysis
Version: 2 Date: 29 Nov 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is the repeat review of the manuscript titled "Inflammatory
bowel disease increases the risk of pancreatitis: A two-sample Mendelian randomization
analysis". Using Mendelian Randomization (MR) approach, authors investigated  the genetic
connections between  IBD (as its Crohn' and Ulcerative colitis subtypes taken separately) and
pancreatitis (acute and chronic subtypes), and possible causal connections between these two
sets of inflammatory conditions. MS is interesting, and reads well. Authors have made necessary
improvements, including expanding the connection of their results to previous MR studies,
performing meta-analysis of 2 databases, and explaining the trends observed in applying three
different MR techniques.
From statistics standpoint, this MS is executed correctly. In my opinion, MS is ready for
publishing now.
ADDITIONAL REQUESTS/SUGGESTIONS:
MS has much improved and now is ready for publishing
Title: Inflammatory bowel disease increases the risk of pancreatitis: A two-sample bidirectional
mendelian randomization analysis
Version: 2 Date: 29 Nov 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is the repeat review of the manuscript titled "Inflammatory
bowel disease increases the risk of pancreatitis: A two-sample Mendelian randomization
analysis". Using Mendelian Randomization (MR) approach, authors investigated  the genetic
connections between  IBD (as its Crohn' and Ulcerative colitis subtypes taken separately) and
pancreatitis (acute and chronic subtypes), and possible causal connections between these two
sets of inflammatory conditions. MS is interesting, and reads well. Authors have made necessary
improvements, including expanding the connection of their results to previous MR studies,
performing meta-analysis of 2 databases, and explaining the trends observed in applying three
different MR techniques.
From statistics standpoint, this MS is executed correctly. In my opinion, MS is ready for
publishing now.
ADDITIONAL REQUESTS/SUGGESTIONS:
MS has much improved and now is ready for publishing
Please review this paper.
user
Title: Inflammatory bowel disease increases the risk of pancreatitis: A two-sample bidirectional
mendelian randomization analysis
Version: 2 Date: 29 Nov 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is the repeat review of the manuscript titled "Inflammatory
bowel disease increases the risk of pancreatitis: A two-sample Mendelian randomization
analysis". Using Mendelian Randomization (MR) approach, authors investigated  the genetic
connections between  IBD (as its Crohn' and Ulcerative colitis subtypes taken separately) and
pancreatitis (acute and chronic subtypes), and possible causal connections between these two
sets of inflammatory conditions. MS is interesting, and reads well. Authors have made necessary
improvements, including expanding the connection of their results to previous MR studies,
performing meta-analysis of 2 databases, and explaining the trends observed in applying three
different MR techniques.
From statistics standpoint, this MS is executed correctly. In my opinion, MS is ready for
publishing now.
ADDITIONAL REQUESTS/SUGGESTIONS:
MS has much improved and now is ready for publishing
assistant