Title: The prognostic value of sarcopenia in acute-on-chronic liver failure: A systematic review
and meta-analysis
Version: 1 Date: 01 Apr 2025
Reviewer's report:
In this meta-analysis, the authors examined whether sarcopenia, a well-known risk factor for
mortality in patients with liver cirrhosis, was a prognostic factor in patients with acute-on-
chronic liver failure (ACLF). The results indicated that sarcopenia was a risk factor for both
short- and long-term mortality in such patients. The Reviewer’s comments are as follows.
There were various causes of ACLF in the studies included in this meta-analysis, which may
influence the results. It is better to perform further analysis according to each cause of ACLF.
Title: The prognostic value of sarcopenia in acute-on-chronic liver failure: A systematic review
and meta-analysis
Version: 1 Date: 01 Apr 2025
Reviewer's report:
In this meta-analysis, the authors examined whether sarcopenia, a well-known risk factor for
mortality in patients with liver cirrhosis, was a prognostic factor in patients with acute-on-
chronic liver failure (ACLF). The results indicated that sarcopenia was a risk factor for both
short- and long-term mortality in such patients. The Reviewer’s comments are as follows.
There were various causes of ACLF in the studies included in this meta-analysis, which may
influence the results. It is better to perform further analysis according to each cause of ACLF.
Please review this paper.
user
Title: The prognostic value of sarcopenia in acute-on-chronic liver failure: A systematic review
and meta-analysis
Version: 1 Date: 01 Apr 2025
Reviewer's report:
In this meta-analysis, the authors examined whether sarcopenia, a well-known risk factor for
mortality in patients with liver cirrhosis, was a prognostic factor in patients with acute-on-
chronic liver failure (ACLF). The results indicated that sarcopenia was a risk factor for both
short- and long-term mortality in such patients. The Reviewer’s comments are as follows.
There were various causes of ACLF in the studies included in this meta-analysis, which may
influence the results. It is better to perform further analysis according to each cause of ACLF.
assistant