Reviewer's report
Title:Small invasive colon cancer with severe distant metastasis: A case report
Version: 3Date:5 February 2011
Reviewer: parham minoo
Reviewer's report:
Minori Matsumoto and colleagues have reported an interesting case of relatively
small sized-colon cancer with aggressive behavior. The authors have described
a 12mm lesion in transverse colon with raised borders and a depressed center
associated with local invasion and distant lymph node metastasis. The authors
have suggested that this case may represent an example of newly described “de
novo” colorectal cancer characterized by distinct pathway of carcinogenesis.
This case is very interesting in the context of clinical presentation and
pathological behavior. The authors did not explain how the molecular pathway for
“de novo” colon cancers is different from traditional adenoma-carcinoma
sequence. If this has not been addressed in the literature, the authors should
acknowledge this and emphasize that their assumption to classify this lesion as
“de novo” colon cancer is just based on the morphology and clinical behavior.
The authors should also include the data from microsatellite instability testing (at
least by Immunohistochemistry) to rule out MSI-H type cancer.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Small invasive colon cancer with severe distant metastasis: A case report
Version: 3Date:5 February 2011
Reviewer: parham minoo
Reviewer's report:
Minori Matsumoto and colleagues have reported an interesting case of relatively
small sized-colon cancer with aggressive behavior. The authors have described
a 12mm lesion in transverse colon with raised borders and a depressed center
associated with local invasion and distant lymph node metastasis. The authors
have suggested that this case may represent an example of newly described “de
novo” colorectal cancer characterized by distinct pathway of carcinogenesis.
This case is very interesting in the context of clinical presentation and
pathological behavior. The authors did not explain how the molecular pathway for
“de novo” colon cancers is different from traditional adenoma-carcinoma
sequence. If this has not been addressed in the literature, the authors should
acknowledge this and emphasize that their assumption to classify this lesion as
“de novo” colon cancer is just based on the morphology and clinical behavior.
The authors should also include the data from microsatellite instability testing (at
least by Immunohistochemistry) to rule out MSI-H type cancer.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Small invasive colon cancer with severe distant metastasis: A case report
Version: 3Date:5 February 2011
Reviewer: parham minoo
Reviewer's report:
Minori Matsumoto and colleagues have reported an interesting case of relatively
small sized-colon cancer with aggressive behavior. The authors have described
a 12mm lesion in transverse colon with raised borders and a depressed center
associated with local invasion and distant lymph node metastasis. The authors
have suggested that this case may represent an example of newly described “de
novo” colorectal cancer characterized by distinct pathway of carcinogenesis.
This case is very interesting in the context of clinical presentation and
pathological behavior. The authors did not explain how the molecular pathway for
“de novo” colon cancers is different from traditional adenoma-carcinoma
sequence. If this has not been addressed in the literature, the authors should
acknowledge this and emphasize that their assumption to classify this lesion as
“de novo” colon cancer is just based on the morphology and clinical behavior.
The authors should also include the data from microsatellite instability testing (at
least by Immunohistochemistry) to rule out MSI-H type cancer.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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