Title: Management of type 1 gastric neuroendocrine tumors: An 11-year retrospective single-
center study
Version: 2 Date: 09 Oct 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a large retrospective study of gastric type 1 NET. This study
is well performed and has a large sample. It is well written. I have few comments
ADDITIONAL REQUESTS/SUGGESTIONS:
Page 7. Results
discovered through gastrocopy due to physical examination... May the authors explain or clarify?
does the patients had a mass? that is unsual in type 1 gastric NET
Results please complete all the autoimmune diseases in order to delete the "etc"
Please specy % of patients with anti parietal cell antibodies, intrinsic factor antibodies, b12
deficiency. please also specify the type of anemia (b12 related, iron deficiency anemia). Patients
with B12 deficiency may have iron deficiency.
May the authors explain why 15 patients had surgery, typically gastrectomy is not the standard
of treatment for NET. Also, please clarify if those were the metastasic or the size-
Also, why 24 received SSA when only 5 were metastatic? This was not discussed
Title: Management of type 1 gastric neuroendocrine tumors: An 11-year retrospective single-
center study
Version: 2 Date: 09 Oct 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a large retrospective study of gastric type 1 NET. This study
is well performed and has a large sample. It is well written. I have few comments
ADDITIONAL REQUESTS/SUGGESTIONS:
Page 7. Results
discovered through gastrocopy due to physical examination... May the authors explain or clarify?
does the patients had a mass? that is unsual in type 1 gastric NET
Results please complete all the autoimmune diseases in order to delete the "etc"
Please specy % of patients with anti parietal cell antibodies, intrinsic factor antibodies, b12
deficiency. please also specify the type of anemia (b12 related, iron deficiency anemia). Patients
with B12 deficiency may have iron deficiency.
May the authors explain why 15 patients had surgery, typically gastrectomy is not the standard
of treatment for NET. Also, please clarify if those were the metastasic or the size-
Also, why 24 received SSA when only 5 were metastatic? This was not discussed
Please review this paper.
user
Title: Management of type 1 gastric neuroendocrine tumors: An 11-year retrospective single-
center study
Version: 2 Date: 09 Oct 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a large retrospective study of gastric type 1 NET. This study
is well performed and has a large sample. It is well written. I have few comments
ADDITIONAL REQUESTS/SUGGESTIONS:
Page 7. Results
discovered through gastrocopy due to physical examination... May the authors explain or clarify?
does the patients had a mass? that is unsual in type 1 gastric NET
Results please complete all the autoimmune diseases in order to delete the "etc"
Please specy % of patients with anti parietal cell antibodies, intrinsic factor antibodies, b12
deficiency. please also specify the type of anemia (b12 related, iron deficiency anemia). Patients
with B12 deficiency may have iron deficiency.
May the authors explain why 15 patients had surgery, typically gastrectomy is not the standard
of treatment for NET. Also, please clarify if those were the metastasic or the size-
Also, why 24 received SSA when only 5 were metastatic? This was not discussed
assistant