Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 1 Date: 02 Dec 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a repeat review of a manuscript titled "Human blood
metabolites and gastric cancer: a Mendelian Randomization Analysis"".
Study demonstrates show causal connections between the genetic components predisposing
individuals to elevated or lowered levels of certain blood metabolites predispose to gastric cancer
or provide protection against the development of this malignant disease.
Manuscript is well written, and much improved after revision.  I see no problems with  statistical
analysis performed.
two small things (not requiring re-reviewing)
1) Please abbreviate phenylalanylphenylalanine to Phe-Phe dipeptide in abstract as well.
2) Please make sure that the gene names (as opposed to proteins)are italicized according to
HUGO convention. For example, in the phrases "in the PPM1K gene", "In the FADS1 gene"
ADDITIONAL REQUESTS/SUGGESTIONS:
Please do small corrections noted above (does not require re-review)
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 1 Date: 02 Dec 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a repeat review of a manuscript titled "Human blood
metabolites and gastric cancer: a Mendelian Randomization Analysis"".
Study demonstrates show causal connections between the genetic components predisposing
individuals to elevated or lowered levels of certain blood metabolites predispose to gastric cancer
or provide protection against the development of this malignant disease.
Manuscript is well written, and much improved after revision.  I see no problems with  statistical
analysis performed.
two small things (not requiring re-reviewing)
1) Please abbreviate phenylalanylphenylalanine to Phe-Phe dipeptide in abstract as well.
2) Please make sure that the gene names (as opposed to proteins)are italicized according to
HUGO convention. For example, in the phrases "in the PPM1K gene", "In the FADS1 gene"
ADDITIONAL REQUESTS/SUGGESTIONS:
Please do small corrections noted above (does not require re-review)
Please review this paper.
user
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 1 Date: 02 Dec 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
Yes - the author's interpretation is reasonable
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a repeat review of a manuscript titled "Human blood
metabolites and gastric cancer: a Mendelian Randomization Analysis"".
Study demonstrates show causal connections between the genetic components predisposing
individuals to elevated or lowered levels of certain blood metabolites predispose to gastric cancer
or provide protection against the development of this malignant disease.
Manuscript is well written, and much improved after revision.  I see no problems with  statistical
analysis performed.
two small things (not requiring re-reviewing)
1) Please abbreviate phenylalanylphenylalanine to Phe-Phe dipeptide in abstract as well.
2) Please make sure that the gene names (as opposed to proteins)are italicized according to
HUGO convention. For example, in the phrases "in the PPM1K gene", "In the FADS1 gene"
ADDITIONAL REQUESTS/SUGGESTIONS:
Please do small corrections noted above (does not require re-review)
assistant