Title: Mucosal healing of small intestinal stricture is associated with improved prognosis post-
dilation in Crohn’s disease
Version: 1 Date: 27 Feb 2022
Reviewer:  Jorge Amil-dias
Reviewer's report:
This is an important study and the authors were careful to consider the various variables that
may influence the prognosis and subsequent need for surgery after elective dilation of the small
bowel. However it is intriguing that the ongoing or previous treatment was not considered with
the same scrutiny and analysis.
Looking at the data file I noticed that most patients were under treatment with 5-ASA or
corticosteroids that are known to be poorly effective (5-ASA) or not promoting mucosal healing
(steroids). The use of biologics may help promote mucosal healing and the subset of patients
using them in appropriate schedule might be analysed on the same endpoint.
It would be interesting to evaluate whether previous aggressive treatment promoting effective
mucosal healing might reduce the need for surgery.
Title: Mucosal healing of small intestinal stricture is associated with improved prognosis post-
dilation in Crohn’s disease
Version: 1 Date: 27 Feb 2022
Reviewer:  Jorge Amil-dias
Reviewer's report:
This is an important study and the authors were careful to consider the various variables that
may influence the prognosis and subsequent need for surgery after elective dilation of the small
bowel. However it is intriguing that the ongoing or previous treatment was not considered with
the same scrutiny and analysis.
Looking at the data file I noticed that most patients were under treatment with 5-ASA or
corticosteroids that are known to be poorly effective (5-ASA) or not promoting mucosal healing
(steroids). The use of biologics may help promote mucosal healing and the subset of patients
using them in appropriate schedule might be analysed on the same endpoint.
It would be interesting to evaluate whether previous aggressive treatment promoting effective
mucosal healing might reduce the need for surgery.
Please review this paper.
user
Title: Mucosal healing of small intestinal stricture is associated with improved prognosis post-
dilation in Crohn’s disease
Version: 1 Date: 27 Feb 2022
Reviewer:  Jorge Amil-dias
Reviewer's report:
This is an important study and the authors were careful to consider the various variables that
may influence the prognosis and subsequent need for surgery after elective dilation of the small
bowel. However it is intriguing that the ongoing or previous treatment was not considered with
the same scrutiny and analysis.
Looking at the data file I noticed that most patients were under treatment with 5-ASA or
corticosteroids that are known to be poorly effective (5-ASA) or not promoting mucosal healing
(steroids). The use of biologics may help promote mucosal healing and the subset of patients
using them in appropriate schedule might be analysed on the same endpoint.
It would be interesting to evaluate whether previous aggressive treatment promoting effective
mucosal healing might reduce the need for surgery.
assistant