Title: Survival Nomograms for Colorectal Carcinoma Patients with Lung Metastasis and Lung-
Only Metastasis, Based on the SEER Database and a Single-Center External Validation Cohort
Version: 2 Date: 24 Aug 2022
Reviewer's report:
The paper is overall well written but there are some flaws that should be addressed.
1) Like many other SEER papers, the manuscript lacks of granularity and several data are
missing. I acknowledge that this is an intrinsic limitation of this kind of studies but the authors
should clearly address it among the limitations
2) English grammar requires some polishing....
3) The external validation cohort is too limited to get reliable assumptions....
4) It would be interesting to speculate on the potential impact of some inflammatory biomarkers,
for example lymphocyte-monocyte ratio (cite the recent paper  PMID: 27122671)
5) Some comments on the surveillance should be also done either in terms of systemic and local
recurrence (cite the paper PMID: 27005802)
Title: Survival Nomograms for Colorectal Carcinoma Patients with Lung Metastasis and Lung-
Only Metastasis, Based on the SEER Database and a Single-Center External Validation Cohort
Version: 2 Date: 24 Aug 2022
Reviewer's report:
The paper is overall well written but there are some flaws that should be addressed.
1) Like many other SEER papers, the manuscript lacks of granularity and several data are
missing. I acknowledge that this is an intrinsic limitation of this kind of studies but the authors
should clearly address it among the limitations
2) English grammar requires some polishing....
3) The external validation cohort is too limited to get reliable assumptions....
4) It would be interesting to speculate on the potential impact of some inflammatory biomarkers,
for example lymphocyte-monocyte ratio (cite the recent paper  PMID: 27122671)
5) Some comments on the surveillance should be also done either in terms of systemic and local
recurrence (cite the paper PMID: 27005802)
Please review this paper.
user
Title: Survival Nomograms for Colorectal Carcinoma Patients with Lung Metastasis and Lung-
Only Metastasis, Based on the SEER Database and a Single-Center External Validation Cohort
Version: 2 Date: 24 Aug 2022
Reviewer's report:
The paper is overall well written but there are some flaws that should be addressed.
1) Like many other SEER papers, the manuscript lacks of granularity and several data are
missing. I acknowledge that this is an intrinsic limitation of this kind of studies but the authors
should clearly address it among the limitations
2) English grammar requires some polishing....
3) The external validation cohort is too limited to get reliable assumptions....
4) It would be interesting to speculate on the potential impact of some inflammatory biomarkers,
for example lymphocyte-monocyte ratio (cite the recent paper  PMID: 27122671)
5) Some comments on the surveillance should be also done either in terms of systemic and local
recurrence (cite the paper PMID: 27005802)
assistant