Title: Ilaprazole-amoxicillin dual therapy at high dose as a first-line treatment for Helicobacter
pylori infection in Hainan: A single-center, open-label, noninferiority, randomized controlled
trial
Version: 3 Date: 10 Jun 2023
Reviewer's report:
Dear Dr. Bai,
Thank you for your efforts in the field of H. pylori eradication. My comments were listed below
1. The bismuth quadruple therapy in your article is not a typical regimen. It only contained one
antibiotic (furazolidone) and the other three drugs provide acid suppression. According to the
updated Maastricht Consensus, this regimen would not sub-optimal for eradication. Although
you had good result, please explain the reason you chose a potential suboptimal regimen .
2. This study enrolled three adolescent patients, please provide the evidence that Eprazole and
bismuth were safe for these adolescent patients.
3. Whether dual high-dosed therapy or suboptimal quadruple therapy , it is reasnable that these
regimen might result in lower eradication rate to enrolled patients. Please provide the rescue
treatment and the result for those patients with treatment failure.
Title: Ilaprazole-amoxicillin dual therapy at high dose as a first-line treatment for Helicobacter
pylori infection in Hainan: A single-center, open-label, noninferiority, randomized controlled
trial
Version: 3 Date: 10 Jun 2023
Reviewer's report:
Dear Dr. Bai,
Thank you for your efforts in the field of H. pylori eradication. My comments were listed below
1. The bismuth quadruple therapy in your article is not a typical regimen. It only contained one
antibiotic (furazolidone) and the other three drugs provide acid suppression. According to the
updated Maastricht Consensus, this regimen would not sub-optimal for eradication. Although
you had good result, please explain the reason you chose a potential suboptimal regimen .
2. This study enrolled three adolescent patients, please provide the evidence that Eprazole and
bismuth were safe for these adolescent patients.
3. Whether dual high-dosed therapy or suboptimal quadruple therapy , it is reasnable that these
regimen might result in lower eradication rate to enrolled patients. Please provide the rescue
treatment and the result for those patients with treatment failure.
Please review this paper.
user
Title: Ilaprazole-amoxicillin dual therapy at high dose as a first-line treatment for Helicobacter
pylori infection in Hainan: A single-center, open-label, noninferiority, randomized controlled
trial
Version: 3 Date: 10 Jun 2023
Reviewer's report:
Dear Dr. Bai,
Thank you for your efforts in the field of H. pylori eradication. My comments were listed below
1. The bismuth quadruple therapy in your article is not a typical regimen. It only contained one
antibiotic (furazolidone) and the other three drugs provide acid suppression. According to the
updated Maastricht Consensus, this regimen would not sub-optimal for eradication. Although
you had good result, please explain the reason you chose a potential suboptimal regimen .
2. This study enrolled three adolescent patients, please provide the evidence that Eprazole and
bismuth were safe for these adolescent patients.
3. Whether dual high-dosed therapy or suboptimal quadruple therapy , it is reasnable that these
regimen might result in lower eradication rate to enrolled patients. Please provide the rescue
treatment and the result for those patients with treatment failure.
assistant