Reviewer's report
Title:Cholestasis induces reversible accumulation of periplakin in mouse liver
Version: 1Date:3 June 2013
Reviewer: Stefano Fiorucci
Reviewer's report:
The study S. Ito et al., suggests that liver accumulation of periplakin occurs in
response to cholestasis and links this finding to the activation of FXR.
Comments
The study contains a number of data and observations appear to be corroborates
by investigating PPl expression in normal and diseased livers. Three models of
cholestasis have been investigated.
I think the data are well presented. I have the following comments: 1. why
GW4064 fails to increase Ppl in the liver; and 2. There is any evidence that the
PpL genes has a putative FXRE in its promoter region?.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no conflict of interest
Reviewer's report
Title:Cholestasis induces reversible accumulation of periplakin in mouse liver
Version: 1Date:3 June 2013
Reviewer: Stefano Fiorucci
Reviewer's report:
The study S. Ito et al., suggests that liver accumulation of periplakin occurs in
response to cholestasis and links this finding to the activation of FXR.
Comments
The study contains a number of data and observations appear to be corroborates
by investigating PPl expression in normal and diseased livers. Three models of
cholestasis have been investigated.
I think the data are well presented. I have the following comments: 1. why
GW4064 fails to increase Ppl in the liver; and 2. There is any evidence that the
PpL genes has a putative FXRE in its promoter region?.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no conflict of interest
Please review this paper.
user
Reviewer's report
Title:Cholestasis induces reversible accumulation of periplakin in mouse liver
Version: 1Date:3 June 2013
Reviewer: Stefano Fiorucci
Reviewer's report:
The study S. Ito et al., suggests that liver accumulation of periplakin occurs in
response to cholestasis and links this finding to the activation of FXR.
Comments
The study contains a number of data and observations appear to be corroborates
by investigating PPl expression in normal and diseased livers. Three models of
cholestasis have been investigated.
I think the data are well presented. I have the following comments: 1. why
GW4064 fails to increase Ppl in the liver; and 2. There is any evidence that the
PpL genes has a putative FXRE in its promoter region?.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no conflict of interest
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