Title: Association between metabolic syndrome and colorectal cancer incidence and all-cause
mortality: a hospital-based observational study
Version: 3 Date: 07 Apr 2022
Reviewer's report:
Using large national database from Taiwan, the authors revealed association between CRC and
the components of MetS. Patients with 3-4 components of MetS had a higher risk of CRC and
all-cause mortality than those with 1-2 components of MetS. To note, they also investigated the
effect of other components, such as co-morbidities and aspirin and/or statin intake. Their study
includes important clinical information and expand our knowledge of CRC.
Major revision:
1. Endoscopic removal of colorectal adenoma is important for primary prevention of colorectal
cancer. If the authors have data of colonoscopy, it would be interesting to do an analysis with
or without colonoscopy. If not, please add it in the limitation.
2. The preventive effect of metformin has been evaluated in RCT (Lancet Oncol 2016; 17:
475-83), the authors should address the association between DM and CRC more detail.
Title: Association between metabolic syndrome and colorectal cancer incidence and all-cause
mortality: a hospital-based observational study
Version: 3 Date: 07 Apr 2022
Reviewer's report:
Using large national database from Taiwan, the authors revealed association between CRC and
the components of MetS. Patients with 3-4 components of MetS had a higher risk of CRC and
all-cause mortality than those with 1-2 components of MetS. To note, they also investigated the
effect of other components, such as co-morbidities and aspirin and/or statin intake. Their study
includes important clinical information and expand our knowledge of CRC.
Major revision:
1. Endoscopic removal of colorectal adenoma is important for primary prevention of colorectal
cancer. If the authors have data of colonoscopy, it would be interesting to do an analysis with
or without colonoscopy. If not, please add it in the limitation.
2. The preventive effect of metformin has been evaluated in RCT (Lancet Oncol 2016; 17:
475-83), the authors should address the association between DM and CRC more detail.
Please review this paper.
user
Title: Association between metabolic syndrome and colorectal cancer incidence and all-cause
mortality: a hospital-based observational study
Version: 3 Date: 07 Apr 2022
Reviewer's report:
Using large national database from Taiwan, the authors revealed association between CRC and
the components of MetS. Patients with 3-4 components of MetS had a higher risk of CRC and
all-cause mortality than those with 1-2 components of MetS. To note, they also investigated the
effect of other components, such as co-morbidities and aspirin and/or statin intake. Their study
includes important clinical information and expand our knowledge of CRC.
Major revision:
1. Endoscopic removal of colorectal adenoma is important for primary prevention of colorectal
cancer. If the authors have data of colonoscopy, it would be interesting to do an analysis with
or without colonoscopy. If not, please add it in the limitation.
2. The preventive effect of metformin has been evaluated in RCT (Lancet Oncol 2016; 17:
475-83), the authors should address the association between DM and CRC more detail.
assistant