Title: Incidental detection of upper gastrointestinal epithelial neoplasia by screening endoscopy
prior to endoscopic ultrasonography in patients with pancreaticobiliary disease
Version: 1 Date: 19 Oct 2023
Reviewer's report:
Comments to the Author
Comment:
In the present study, the authors investigated the utility of screening
esophagogastroduodenoscopy performed sequentially with endoscopic ultrasonography for
patients with pancreaticobiliary disease. The authors described in this article that the detection
rate of gastric epithelial neoplasms in the protocol was higher than that in the medical checkup
center. The authors also suggested that magnification endoscopy may facilitate detection in the
protocol. It is clinically valuable to examine the usefulness of this protocol, however, as many
institutions are probably already conducting this protocol. However, the manuscript has several
flaws that need to be assessed.
Comments
##      In Japan, Helicobacter pylori (H. pylori) is the main causative factor of gastric cancer.
  Regarding the Characteristics in Table 1, do you have any data on H. pylori infection?
## Comments on the comparison of gastric epithelial neoplasia detection rates between the EUS
and MCC groups: 31.1% of the EUS group used a magnification endoscope while the MCC
group did not use a magnification endoscope. Is there an analysis of both groups only with
subjects not using the magnification endoscope?
Title: Incidental detection of upper gastrointestinal epithelial neoplasia by screening endoscopy
prior to endoscopic ultrasonography in patients with pancreaticobiliary disease
Version: 1 Date: 19 Oct 2023
Reviewer's report:
Comments to the Author
Comment:
In the present study, the authors investigated the utility of screening
esophagogastroduodenoscopy performed sequentially with endoscopic ultrasonography for
patients with pancreaticobiliary disease. The authors described in this article that the detection
rate of gastric epithelial neoplasms in the protocol was higher than that in the medical checkup
center. The authors also suggested that magnification endoscopy may facilitate detection in the
protocol. It is clinically valuable to examine the usefulness of this protocol, however, as many
institutions are probably already conducting this protocol. However, the manuscript has several
flaws that need to be assessed.
Comments
##      In Japan, Helicobacter pylori (H. pylori) is the main causative factor of gastric cancer.
  Regarding the Characteristics in Table 1, do you have any data on H. pylori infection?
## Comments on the comparison of gastric epithelial neoplasia detection rates between the EUS
and MCC groups: 31.1% of the EUS group used a magnification endoscope while the MCC
group did not use a magnification endoscope. Is there an analysis of both groups only with
subjects not using the magnification endoscope?
Please review this paper.
user
Title: Incidental detection of upper gastrointestinal epithelial neoplasia by screening endoscopy
prior to endoscopic ultrasonography in patients with pancreaticobiliary disease
Version: 1 Date: 19 Oct 2023
Reviewer's report:
Comments to the Author
Comment:
In the present study, the authors investigated the utility of screening
esophagogastroduodenoscopy performed sequentially with endoscopic ultrasonography for
patients with pancreaticobiliary disease. The authors described in this article that the detection
rate of gastric epithelial neoplasms in the protocol was higher than that in the medical checkup
center. The authors also suggested that magnification endoscopy may facilitate detection in the
protocol. It is clinically valuable to examine the usefulness of this protocol, however, as many
institutions are probably already conducting this protocol. However, the manuscript has several
flaws that need to be assessed.
Comments
##      In Japan, Helicobacter pylori (H. pylori) is the main causative factor of gastric cancer.
  Regarding the Characteristics in Table 1, do you have any data on H. pylori infection?
## Comments on the comparison of gastric epithelial neoplasia detection rates between the EUS
and MCC groups: 31.1% of the EUS group used a magnification endoscope while the MCC
group did not use a magnification endoscope. Is there an analysis of both groups only with
subjects not using the magnification endoscope?
assistant