Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 1 Date: 06 Jul 2022
Reviewer's report:
Thank you for the opportunity to review a manuscript entitled “Sex-dependent associations
between MAP3K1 gene polymorphisms and soy products with the incidence of gastric cancer in
Korea: A case-control study” by Jung Hyun Kwak and his colleagues in BMC Gastroenterology.
In this paper, the authors investigated the association between MAP3K1 gene polymorphisms
and GC incidence by sex and whether these associations differ depending on soy product intake.
They made a conclusion that men with the risk allele of MAP3K1 had a significantly increased
risk of GC incidence compared to GG homozygotes and this trend was more pronounced in
those with low intake of soy products. However, the authors collected the participants between
December 2002 and September 2006, almost two decades ago. The behavior and eating habits
have changed dramatically during 20 years worldwide, including Korea undoubtedly. So the
significance of this study has been greatly weakened due to the backwardness of samples.
Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 1 Date: 06 Jul 2022
Reviewer's report:
Thank you for the opportunity to review a manuscript entitled “Sex-dependent associations
between MAP3K1 gene polymorphisms and soy products with the incidence of gastric cancer in
Korea: A case-control study” by Jung Hyun Kwak and his colleagues in BMC Gastroenterology.
In this paper, the authors investigated the association between MAP3K1 gene polymorphisms
and GC incidence by sex and whether these associations differ depending on soy product intake.
They made a conclusion that men with the risk allele of MAP3K1 had a significantly increased
risk of GC incidence compared to GG homozygotes and this trend was more pronounced in
those with low intake of soy products. However, the authors collected the participants between
December 2002 and September 2006, almost two decades ago. The behavior and eating habits
have changed dramatically during 20 years worldwide, including Korea undoubtedly. So the
significance of this study has been greatly weakened due to the backwardness of samples.
Please review this paper.
user
Title: Sex-dependent associations between MAP3K1 gene polymorphisms and soy products
with the gastric cancer risk in Korea: A case-control study
Version: 1 Date: 06 Jul 2022
Reviewer's report:
Thank you for the opportunity to review a manuscript entitled “Sex-dependent associations
between MAP3K1 gene polymorphisms and soy products with the incidence of gastric cancer in
Korea: A case-control study” by Jung Hyun Kwak and his colleagues in BMC Gastroenterology.
In this paper, the authors investigated the association between MAP3K1 gene polymorphisms
and GC incidence by sex and whether these associations differ depending on soy product intake.
They made a conclusion that men with the risk allele of MAP3K1 had a significantly increased
risk of GC incidence compared to GG homozygotes and this trend was more pronounced in
those with low intake of soy products. However, the authors collected the participants between
December 2002 and September 2006, almost two decades ago. The behavior and eating habits
have changed dramatically during 20 years worldwide, including Korea undoubtedly. So the
significance of this study has been greatly weakened due to the backwardness of samples.
assistant