Title: Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal
cancer: a retrospective multicenter study
Version: 3 Date: 16 Jun 2023
Reviewer's report:
Thank you for the manuscript regarding Oncologic relevance of genetic alterations in sporadic
synchronous and solitary colorectal cancer. The article is devoted to an actual topic, namely the
significance of genetic changes in genes in synchronous and solitary tumors in patients with
colorectal cancer. The research carried out is undoubtedly interesting. However, there are some
clarifications and questions.
1. Why exons 3 and 4 of the gene were not studied of KRAS gene? It is need to be clarified
in the article.
2. Did all patients with MSI it have the BRAF mutation? It is not clear from the text of the
article, it is necessary to clarify
In general, the article can be accepted for publication after some clarifications.
Title: Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal
cancer: a retrospective multicenter study
Version: 3 Date: 16 Jun 2023
Reviewer's report:
Thank you for the manuscript regarding Oncologic relevance of genetic alterations in sporadic
synchronous and solitary colorectal cancer. The article is devoted to an actual topic, namely the
significance of genetic changes in genes in synchronous and solitary tumors in patients with
colorectal cancer. The research carried out is undoubtedly interesting. However, there are some
clarifications and questions.
1. Why exons 3 and 4 of the gene were not studied of KRAS gene? It is need to be clarified
in the article.
2. Did all patients with MSI it have the BRAF mutation? It is not clear from the text of the
article, it is necessary to clarify
In general, the article can be accepted for publication after some clarifications.
Please review this paper.
user
Title: Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal
cancer: a retrospective multicenter study
Version: 3 Date: 16 Jun 2023
Reviewer's report:
Thank you for the manuscript regarding Oncologic relevance of genetic alterations in sporadic
synchronous and solitary colorectal cancer. The article is devoted to an actual topic, namely the
significance of genetic changes in genes in synchronous and solitary tumors in patients with
colorectal cancer. The research carried out is undoubtedly interesting. However, there are some
clarifications and questions.
1. Why exons 3 and 4 of the gene were not studied of KRAS gene? It is need to be clarified
in the article.
2. Did all patients with MSI it have the BRAF mutation? It is not clear from the text of the
article, it is necessary to clarify
In general, the article can be accepted for publication after some clarifications.
assistant