Title: The Diagnostic Value of Dynamic Contrast-Enhanced Ultrasound for Evaluation of
Tissue Oxygen Status in Rat Hepatoma Model
Version: 2 Date: 15 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Because hypoxia was not recorded  the experimental model can verify that CEUS can measure
normal oxygenation and in such a condition there is a good correlation between CEUS
parameters and pO2 Thus conclusions should be accordingly adapted Methods Authors should
explain why they have selected tumor diameters of 10 and 15 mm which proved to be
insufficient to produce hypoxia An additional group with hypoxia would have been perfect
Afterall immunohistochemistry for hypoxia proved to be a useless additive
Title: The Diagnostic Value of Dynamic Contrast-Enhanced Ultrasound for Evaluation of
Tissue Oxygen Status in Rat Hepatoma Model
Version: 2 Date: 15 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Because hypoxia was not recorded  the experimental model can verify that CEUS can measure
normal oxygenation and in such a condition there is a good correlation between CEUS
parameters and pO2 Thus conclusions should be accordingly adapted Methods Authors should
explain why they have selected tumor diameters of 10 and 15 mm which proved to be
insufficient to produce hypoxia An additional group with hypoxia would have been perfect
Afterall immunohistochemistry for hypoxia proved to be a useless additive
Please review this paper.
user
Title: The Diagnostic Value of Dynamic Contrast-Enhanced Ultrasound for Evaluation of
Tissue Oxygen Status in Rat Hepatoma Model
Version: 2 Date: 15 Oct 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Because hypoxia was not recorded  the experimental model can verify that CEUS can measure
normal oxygenation and in such a condition there is a good correlation between CEUS
parameters and pO2 Thus conclusions should be accordingly adapted Methods Authors should
explain why they have selected tumor diameters of 10 and 15 mm which proved to be
insufficient to produce hypoxia An additional group with hypoxia would have been perfect
Afterall immunohistochemistry for hypoxia proved to be a useless additive
assistant