Reviewer's report
Title:Activity of Corilagin to treat animal model of acute cholestasis by
anti-inflammatory and anti-oxidative pathway
Version: 1Date:5 December 2012
Reviewer: Bo Yan
Reviewer's report:
Major compulsory revision:
In this study, effects of corilagin on inflammation and oxidation were investigated
in animal model of acute cholestasis. Several physiological and biochemical
parameters were examined within 3 days post-administration of corilagin.
According to these results, authors concluded that Corilagin is a potential
component to relieve cholestasis. In general, this is a preliminary and short-term
study, which was well conducted. My major concern is the duration of
observation. Long-term effects may provide strong support for their conclusions.
Minor points:
1. In the Instruction section, please explain why corilagin was chosen in this
study.
2. In this study, 90 animals were divided into 5 groups, which indicated that each
group had less than 20 animals. The results would be more convincing with more
animals in each group.
3. Please clarify each group in detail in the Results section.
4. It is suggested that all author go over the whole manuscript to correct English
writings as a group.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Activity of Corilagin to treat animal model of acute cholestasis by
anti-inflammatory and anti-oxidative pathway
Version: 1Date:5 December 2012
Reviewer: Bo Yan
Reviewer's report:
Major compulsory revision:
In this study, effects of corilagin on inflammation and oxidation were investigated
in animal model of acute cholestasis. Several physiological and biochemical
parameters were examined within 3 days post-administration of corilagin.
According to these results, authors concluded that Corilagin is a potential
component to relieve cholestasis. In general, this is a preliminary and short-term
study, which was well conducted. My major concern is the duration of
observation. Long-term effects may provide strong support for their conclusions.
Minor points:
1. In the Instruction section, please explain why corilagin was chosen in this
study.
2. In this study, 90 animals were divided into 5 groups, which indicated that each
group had less than 20 animals. The results would be more convincing with more
animals in each group.
3. Please clarify each group in detail in the Results section.
4. It is suggested that all author go over the whole manuscript to correct English
writings as a group.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Activity of Corilagin to treat animal model of acute cholestasis by
anti-inflammatory and anti-oxidative pathway
Version: 1Date:5 December 2012
Reviewer: Bo Yan
Reviewer's report:
Major compulsory revision:
In this study, effects of corilagin on inflammation and oxidation were investigated
in animal model of acute cholestasis. Several physiological and biochemical
parameters were examined within 3 days post-administration of corilagin.
According to these results, authors concluded that Corilagin is a potential
component to relieve cholestasis. In general, this is a preliminary and short-term
study, which was well conducted. My major concern is the duration of
observation. Long-term effects may provide strong support for their conclusions.
Minor points:
1. In the Instruction section, please explain why corilagin was chosen in this
study.
2. In this study, 90 animals were divided into 5 groups, which indicated that each
group had less than 20 animals. The results would be more convincing with more
animals in each group.
3. Please clarify each group in detail in the Results section.
4. It is suggested that all author go over the whole manuscript to correct English
writings as a group.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant