Title: Efficacy of extracorporeal immunoadsorption therapy for removal of HBsAg
Version: 1 Date: 20 Feb 2025
Reviewer's report:
Dear Sirs/Madams,
I really enjoyed your article.
I understand you want to commercialize your research and in this case many details in the article
were missing.  If this article is about affinity resin preparation, where there is no discussion about
ligand and matrix itself, why exactly did these were used. Ligand interaction with vivo objects
was not investigated. Even if your experiments (cytotoxicity and rabbits) show what resin looks
safe, you have not investigated the worst case, when your ligand will start to leak in some case,
which is pretty common for such affinity resins.
If you are working on the platform for this method to obtain immunoadsorption medical devices
it is a good step, but HBsAG probably not hottest target for it.
I think you did great work and wish you luck in your further research and real product
development.
Kind regards
Title: Efficacy of extracorporeal immunoadsorption therapy for removal of HBsAg
Version: 1 Date: 20 Feb 2025
Reviewer's report:
Dear Sirs/Madams,
I really enjoyed your article.
I understand you want to commercialize your research and in this case many details in the article
were missing.  If this article is about affinity resin preparation, where there is no discussion about
ligand and matrix itself, why exactly did these were used. Ligand interaction with vivo objects
was not investigated. Even if your experiments (cytotoxicity and rabbits) show what resin looks
safe, you have not investigated the worst case, when your ligand will start to leak in some case,
which is pretty common for such affinity resins.
If you are working on the platform for this method to obtain immunoadsorption medical devices
it is a good step, but HBsAG probably not hottest target for it.
I think you did great work and wish you luck in your further research and real product
development.
Kind regards
Please review this paper.
user
Title: Efficacy of extracorporeal immunoadsorption therapy for removal of HBsAg
Version: 1 Date: 20 Feb 2025
Reviewer's report:
Dear Sirs/Madams,
I really enjoyed your article.
I understand you want to commercialize your research and in this case many details in the article
were missing.  If this article is about affinity resin preparation, where there is no discussion about
ligand and matrix itself, why exactly did these were used. Ligand interaction with vivo objects
was not investigated. Even if your experiments (cytotoxicity and rabbits) show what resin looks
safe, you have not investigated the worst case, when your ligand will start to leak in some case,
which is pretty common for such affinity resins.
If you are working on the platform for this method to obtain immunoadsorption medical devices
it is a good step, but HBsAG probably not hottest target for it.
I think you did great work and wish you luck in your further research and real product
development.
Kind regards
assistant