Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 1 Date: 09 Aug 2024
Reviewer:  Yi-Chuan Yu
Reviewer's report:
Many thanks to the authors’ responses and revisions. There are still many grammar and spelling
typos throughout this revised manuscript. Besides, the methods section in the revised manuscript
still requires some heavy revisions. My specific comments are listed below.
1. “Alcohol related liver disease” should be revised to “Alcohol-related liver disease”
2. “The RCS indicated that there is not a linear relationship between LE8 and cardiovascular
mortality.” Should be revised to “The RCS indicated that there is NO linear relationship between
LE8 and cardiovascular mortality.”
3. “LE8 socre is inversely and…” should be revised to “LE8 SCORE is inversely and…”
4. I appreciate the authors’ responses on how LE8 is calculated. However, as the primary
exposure variable of the study, a detailed derivation of LE8 should be included for the
transparency of the article and for the reproducibility of all potential future research.
5. Please provide a detailed explanation of how the 63-month median follow-up time is
calculated. Are all the essential variables for LE8 measured on the same day for the participants?
If not, how do the authors handle the inconsistent start date in the Cox model? Besides, if
participants without follow-up data were excluded, why not include these individuals in Figure
1?
6. “…which measures adherence to a set of lifestyle behaviors and health factors, including
healthy diet…” should be “which measures adherence to a set of lifestyle behaviors and health
factors, including A healthy diet”.
7. There are 2 “the”s in the following statement: “Our study also revealed the dose-response
relationship between LE8 score and the the risk of long-term mortality in ALD patients using
restricted cubic splines (RCS), which has not been previously reported.”
8. Figure 3 seems to be mis-uploaded to the system.
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 1 Date: 09 Aug 2024
Reviewer:  Yi-Chuan Yu
Reviewer's report:
Many thanks to the authors’ responses and revisions. There are still many grammar and spelling
typos throughout this revised manuscript. Besides, the methods section in the revised manuscript
still requires some heavy revisions. My specific comments are listed below.
1. “Alcohol related liver disease” should be revised to “Alcohol-related liver disease”
2. “The RCS indicated that there is not a linear relationship between LE8 and cardiovascular
mortality.” Should be revised to “The RCS indicated that there is NO linear relationship between
LE8 and cardiovascular mortality.”
3. “LE8 socre is inversely and…” should be revised to “LE8 SCORE is inversely and…”
4. I appreciate the authors’ responses on how LE8 is calculated. However, as the primary
exposure variable of the study, a detailed derivation of LE8 should be included for the
transparency of the article and for the reproducibility of all potential future research.
5. Please provide a detailed explanation of how the 63-month median follow-up time is
calculated. Are all the essential variables for LE8 measured on the same day for the participants?
If not, how do the authors handle the inconsistent start date in the Cox model? Besides, if
participants without follow-up data were excluded, why not include these individuals in Figure
1?
6. “…which measures adherence to a set of lifestyle behaviors and health factors, including
healthy diet…” should be “which measures adherence to a set of lifestyle behaviors and health
factors, including A healthy diet”.
7. There are 2 “the”s in the following statement: “Our study also revealed the dose-response
relationship between LE8 score and the the risk of long-term mortality in ALD patients using
restricted cubic splines (RCS), which has not been previously reported.”
8. Figure 3 seems to be mis-uploaded to the system.
Please review this paper.
user
Title: Association of Life’s Essential 8 with Mortalities in Patients with Alcohol-Related Liver
Disease
Version: 1 Date: 09 Aug 2024
Reviewer:  Yi-Chuan Yu
Reviewer's report:
Many thanks to the authors’ responses and revisions. There are still many grammar and spelling
typos throughout this revised manuscript. Besides, the methods section in the revised manuscript
still requires some heavy revisions. My specific comments are listed below.
1. “Alcohol related liver disease” should be revised to “Alcohol-related liver disease”
2. “The RCS indicated that there is not a linear relationship between LE8 and cardiovascular
mortality.” Should be revised to “The RCS indicated that there is NO linear relationship between
LE8 and cardiovascular mortality.”
3. “LE8 socre is inversely and…” should be revised to “LE8 SCORE is inversely and…”
4. I appreciate the authors’ responses on how LE8 is calculated. However, as the primary
exposure variable of the study, a detailed derivation of LE8 should be included for the
transparency of the article and for the reproducibility of all potential future research.
5. Please provide a detailed explanation of how the 63-month median follow-up time is
calculated. Are all the essential variables for LE8 measured on the same day for the participants?
If not, how do the authors handle the inconsistent start date in the Cox model? Besides, if
participants without follow-up data were excluded, why not include these individuals in Figure
1?
6. “…which measures adherence to a set of lifestyle behaviors and health factors, including
healthy diet…” should be “which measures adherence to a set of lifestyle behaviors and health
factors, including A healthy diet”.
7. There are 2 “the”s in the following statement: “Our study also revealed the dose-response
relationship between LE8 score and the the risk of long-term mortality in ALD patients using
restricted cubic splines (RCS), which has not been previously reported.”
8. Figure 3 seems to be mis-uploaded to the system.
assistant