Title: A method of “Noninjecting Resection using Bipolar Soft coagulation mode; NIRBS” for
superficial non-ampullary duodenal epithelial tumor: A pilot study
Version: 5 Date: 19 Aug 2024
Reviewer's report:
In this paper, Tokuhara M et al. reported the efficacy and safety of a novel endoscopic
resection method, "Noninjecting Resection using Bipolar Soft Coagulation Mode (NIRBS),"
for superficial non-ampullary duodenal epithelial tumors (SNADETs). Given the technical
challenges and high risk of complications associated with endoscopic treatment of duodenal
lesions, the development of a new technique is highly significant. Moreover, despite the
challenges posed by biopsy scars, en bloc resection was successfully performed in two patients
with such scars, although endoscopic resection (ER) can be difficult in these cases. No adverse
events (AEs) such as perforation or bleeding occurred in this study. Therefore, NIRBS appears
to be highly suitable for ER of SNADETs. Based on these findings, I recommend accepting this
manuscript for publication; however, I suggest that the authors consider one revision.
1) While this study strongly supports the efficacy and safety of NIRBS, I recommend adding
a more detailed comparison between NIRBS and other existing resection techniques, such as
Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD), in the
discussion section. For example, you could compare the shorter procedure time, lower risk of
complications, or the simplicity of the NIRBS technique relative to these other methods. This
comparison would clarify the relative advantages and limitations of NIRBS, making it easier for
readers to determine how best to apply NIRBS in clinical practice.
Title: A method of “Noninjecting Resection using Bipolar Soft coagulation mode; NIRBS” for
superficial non-ampullary duodenal epithelial tumor: A pilot study
Version: 5 Date: 19 Aug 2024
Reviewer's report:
In this paper, Tokuhara M et al. reported the efficacy and safety of a novel endoscopic
resection method, "Noninjecting Resection using Bipolar Soft Coagulation Mode (NIRBS),"
for superficial non-ampullary duodenal epithelial tumors (SNADETs). Given the technical
challenges and high risk of complications associated with endoscopic treatment of duodenal
lesions, the development of a new technique is highly significant. Moreover, despite the
challenges posed by biopsy scars, en bloc resection was successfully performed in two patients
with such scars, although endoscopic resection (ER) can be difficult in these cases. No adverse
events (AEs) such as perforation or bleeding occurred in this study. Therefore, NIRBS appears
to be highly suitable for ER of SNADETs. Based on these findings, I recommend accepting this
manuscript for publication; however, I suggest that the authors consider one revision.
1) While this study strongly supports the efficacy and safety of NIRBS, I recommend adding
a more detailed comparison between NIRBS and other existing resection techniques, such as
Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD), in the
discussion section. For example, you could compare the shorter procedure time, lower risk of
complications, or the simplicity of the NIRBS technique relative to these other methods. This
comparison would clarify the relative advantages and limitations of NIRBS, making it easier for
readers to determine how best to apply NIRBS in clinical practice.
Please review this paper.
user
Title: A method of “Noninjecting Resection using Bipolar Soft coagulation mode; NIRBS” for
superficial non-ampullary duodenal epithelial tumor: A pilot study
Version: 5 Date: 19 Aug 2024
Reviewer's report:
In this paper, Tokuhara M et al. reported the efficacy and safety of a novel endoscopic
resection method, "Noninjecting Resection using Bipolar Soft Coagulation Mode (NIRBS),"
for superficial non-ampullary duodenal epithelial tumors (SNADETs). Given the technical
challenges and high risk of complications associated with endoscopic treatment of duodenal
lesions, the development of a new technique is highly significant. Moreover, despite the
challenges posed by biopsy scars, en bloc resection was successfully performed in two patients
with such scars, although endoscopic resection (ER) can be difficult in these cases. No adverse
events (AEs) such as perforation or bleeding occurred in this study. Therefore, NIRBS appears
to be highly suitable for ER of SNADETs. Based on these findings, I recommend accepting this
manuscript for publication; however, I suggest that the authors consider one revision.
1) While this study strongly supports the efficacy and safety of NIRBS, I recommend adding
a more detailed comparison between NIRBS and other existing resection techniques, such as
Endoscopic Mucosal Resection (EMR) and Endoscopic Submucosal Dissection (ESD), in the
discussion section. For example, you could compare the shorter procedure time, lower risk of
complications, or the simplicity of the NIRBS technique relative to these other methods. This
comparison would clarify the relative advantages and limitations of NIRBS, making it easier for
readers to determine how best to apply NIRBS in clinical practice.
assistant