Title: Causal relationship between Hypothyroidism and Ulcerative Colitis: a Bidirectional
Mendelian Randomization study
Version: 3 Date: 15 Aug 2024
Reviewer's report:
1---Your use of bidirectional Mendelian randomization is commendable. However, there may be
opportunities to strengthen the approach, perhaps by considering additional sensitivity analyses
or methods to validate your genetic instruments.
2---While your statistical approach is sound, providing more detail on your methods, particularly
for addressing potential pleiotropy, could enhance the reproducibility of your work.
3---it's exciting to consider the potential clinical implications of your work, it might be helpful
to temper these discussions with acknowledgment of the need for further research to confirm
and extend your findings.
4---Consider elaborating on how hypothyroidism and ulcerative colitis were defined in your
study. Clearer definitions could enhance the reliability of your outcome measures.
Title: Causal relationship between Hypothyroidism and Ulcerative Colitis: a Bidirectional
Mendelian Randomization study
Version: 3 Date: 15 Aug 2024
Reviewer's report:
1---Your use of bidirectional Mendelian randomization is commendable. However, there may be
opportunities to strengthen the approach, perhaps by considering additional sensitivity analyses
or methods to validate your genetic instruments.
2---While your statistical approach is sound, providing more detail on your methods, particularly
for addressing potential pleiotropy, could enhance the reproducibility of your work.
3---it's exciting to consider the potential clinical implications of your work, it might be helpful
to temper these discussions with acknowledgment of the need for further research to confirm
and extend your findings.
4---Consider elaborating on how hypothyroidism and ulcerative colitis were defined in your
study. Clearer definitions could enhance the reliability of your outcome measures.
Please review this paper.
user
Title: Causal relationship between Hypothyroidism and Ulcerative Colitis: a Bidirectional
Mendelian Randomization study
Version: 3 Date: 15 Aug 2024
Reviewer's report:
1---Your use of bidirectional Mendelian randomization is commendable. However, there may be
opportunities to strengthen the approach, perhaps by considering additional sensitivity analyses
or methods to validate your genetic instruments.
2---While your statistical approach is sound, providing more detail on your methods, particularly
for addressing potential pleiotropy, could enhance the reproducibility of your work.
3---it's exciting to consider the potential clinical implications of your work, it might be helpful
to temper these discussions with acknowledgment of the need for further research to confirm
and extend your findings.
4---Consider elaborating on how hypothyroidism and ulcerative colitis were defined in your
study. Clearer definitions could enhance the reliability of your outcome measures.
assistant