Title: Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in
nonalcoholic steatohepatitis
Version: 1 Date: 02 Nov 2022
Reviewer's report:
The authors assessed soluble CD163 as a predictor of fibrosis and hepatocellular carcinoma
development in nonalcoholic steatohepatitis; the study is interesting and well written; However:
=Sample size analysis and power of the study is needed to validate the results of the study.
=Discussion: Comparison with other markers are needed to better demonstrate the validity of
this marker.
=References need to be updated with important references about some markers in HCC
development in hepatic patients; I suggest some revlevant references:
-El-Gebaly F, Abou-Saif S, Elkadeem M, et al. Study of Serum Soluble Programmed Death
Ligand 1 as a Prognostic Factor in Hepatocellular Carcinoma in Egyptian Patients. Curr Cancer
Drug Targets. 2019; 19(11):896-905.
-Watany M, Badawi R, Elkhalawany W, et al. Study of Dickkopf-1 (DKK-1) Gene Expression
in Hepatocellular Carcinoma Patients. J Clin Diagn Res. 2017 Feb; 11(2):OC32-OC34.
-Elhendawy M, Abdul-Baki EA, Abd-Elsalam S, et al. MicroRNA signature in
hepatocellular carcinoma patients: identification of potential markers. Mol Biol Rep. 2020
Jul;47(7):4945-4953.
Title: Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in
nonalcoholic steatohepatitis
Version: 1 Date: 02 Nov 2022
Reviewer's report:
The authors assessed soluble CD163 as a predictor of fibrosis and hepatocellular carcinoma
development in nonalcoholic steatohepatitis; the study is interesting and well written; However:
=Sample size analysis and power of the study is needed to validate the results of the study.
=Discussion: Comparison with other markers are needed to better demonstrate the validity of
this marker.
=References need to be updated with important references about some markers in HCC
development in hepatic patients; I suggest some revlevant references:
-El-Gebaly F, Abou-Saif S, Elkadeem M, et al. Study of Serum Soluble Programmed Death
Ligand 1 as a Prognostic Factor in Hepatocellular Carcinoma in Egyptian Patients. Curr Cancer
Drug Targets. 2019; 19(11):896-905.
-Watany M, Badawi R, Elkhalawany W, et al. Study of Dickkopf-1 (DKK-1) Gene Expression
in Hepatocellular Carcinoma Patients. J Clin Diagn Res. 2017 Feb; 11(2):OC32-OC34.
-Elhendawy M, Abdul-Baki EA, Abd-Elsalam S, et al. MicroRNA signature in
hepatocellular carcinoma patients: identification of potential markers. Mol Biol Rep. 2020
Jul;47(7):4945-4953.
Please review this paper.
user
Title: Soluble CD163 is a predictor of fibrosis and hepatocellular carcinoma development in
nonalcoholic steatohepatitis
Version: 1 Date: 02 Nov 2022
Reviewer's report:
The authors assessed soluble CD163 as a predictor of fibrosis and hepatocellular carcinoma
development in nonalcoholic steatohepatitis; the study is interesting and well written; However:
=Sample size analysis and power of the study is needed to validate the results of the study.
=Discussion: Comparison with other markers are needed to better demonstrate the validity of
this marker.
=References need to be updated with important references about some markers in HCC
development in hepatic patients; I suggest some revlevant references:
-El-Gebaly F, Abou-Saif S, Elkadeem M, et al. Study of Serum Soluble Programmed Death
Ligand 1 as a Prognostic Factor in Hepatocellular Carcinoma in Egyptian Patients. Curr Cancer
Drug Targets. 2019; 19(11):896-905.
-Watany M, Badawi R, Elkhalawany W, et al. Study of Dickkopf-1 (DKK-1) Gene Expression
in Hepatocellular Carcinoma Patients. J Clin Diagn Res. 2017 Feb; 11(2):OC32-OC34.
-Elhendawy M, Abdul-Baki EA, Abd-Elsalam S, et al. MicroRNA signature in
hepatocellular carcinoma patients: identification of potential markers. Mol Biol Rep. 2020
Jul;47(7):4945-4953.
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