Title: Long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver
failure: a retrospective study
Version: 3 Date: 19 Jan 2022
Reviewer:  Premashish Kar
Reviewer's report:
1. It is not mentioned in t  text of the paper whether it is a prospective or retrospective study,
this should be mentioned in the methodology.
2. The various risk factors assessing the long term prognosis of the in both study groups should
be mentioned clearly in the methodology .
3. It was not mentioned what were the non cirrhotic cases in these groups
4. What was the distribution of the cases of cirrhosis with refer to child Pugh score
5. Why was liver biopsy done to document the diagnosis cirrhosis when it could have been made
on the basis of clinically features imaging and radiological features. how this was overlooked
by the ethical community of the institution.
These days liver biopsy is never done for confirmation of cirrhosis
Limitations of such retrospective  interpretation of data for clinical interpretation requires
validation and this should be mentioned in the discussion
Title: Long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver
failure: a retrospective study
Version: 3 Date: 19 Jan 2022
Reviewer:  Premashish Kar
Reviewer's report:
1. It is not mentioned in t  text of the paper whether it is a prospective or retrospective study,
this should be mentioned in the methodology.
2. The various risk factors assessing the long term prognosis of the in both study groups should
be mentioned clearly in the methodology .
3. It was not mentioned what were the non cirrhotic cases in these groups
4. What was the distribution of the cases of cirrhosis with refer to child Pugh score
5. Why was liver biopsy done to document the diagnosis cirrhosis when it could have been made
on the basis of clinically features imaging and radiological features. how this was overlooked
by the ethical community of the institution.
These days liver biopsy is never done for confirmation of cirrhosis
Limitations of such retrospective  interpretation of data for clinical interpretation requires
validation and this should be mentioned in the discussion
Please review this paper.
user
Title: Long-term prognosis of patients with hepatitis B virus-related acute-on-chronic liver
failure: a retrospective study
Version: 3 Date: 19 Jan 2022
Reviewer:  Premashish Kar
Reviewer's report:
1. It is not mentioned in t  text of the paper whether it is a prospective or retrospective study,
this should be mentioned in the methodology.
2. The various risk factors assessing the long term prognosis of the in both study groups should
be mentioned clearly in the methodology .
3. It was not mentioned what were the non cirrhotic cases in these groups
4. What was the distribution of the cases of cirrhosis with refer to child Pugh score
5. Why was liver biopsy done to document the diagnosis cirrhosis when it could have been made
on the basis of clinically features imaging and radiological features. how this was overlooked
by the ethical community of the institution.
These days liver biopsy is never done for confirmation of cirrhosis
Limitations of such retrospective  interpretation of data for clinical interpretation requires
validation and this should be mentioned in the discussion
assistant