Reviewer's report 
 Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary Title: 
infection: Case report 
 3  23 November 2005 Version: Date: 
 Jerome Dumortier Reviewer: 
Reviewer's report: 
Spahr and coll. report the case of a young woman who presented the association of a portal and 
hepatic vein thrombosis during an acute cytomegalovirus primoinfection with probable liver involvement. The paper is interesting because of the rarity of such complication of CMV infection. 
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I have some comments on the case. 
1/ Did the authors explore the other causes of liver diseases, especially auto-immunity in this young 
woman ? Did histological examination exclude a pre-existing liver disease ? 
2/ Was the patient treated with ganciclovir or other antiviral treatment ? If not, this point has to be 
discussed. 
3/ Did the authors detect DNA-CMV by PCR on the liver biopsy ? 
4/ The authors state that the patient was immunocompetent. What were the explorations made ? 
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 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research Level of interest: 
interests 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests'
Reviewer's report 
 Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary Title: 
infection: Case report 
 3  23 November 2005 Version: Date: 
 Jerome Dumortier Reviewer: 
Reviewer's report: 
Spahr and coll. report the case of a young woman who presented the association of a portal and 
hepatic vein thrombosis during an acute cytomegalovirus primoinfection with probable liver involvement. The paper is interesting because of the rarity of such complication of CMV infection. 
------------------------------------------------------------------------------- 
------------------------------------------------------------------------------- 
I have some comments on the case. 
1/ Did the authors explore the other causes of liver diseases, especially auto-immunity in this young 
woman ? Did histological examination exclude a pre-existing liver disease ? 
2/ Was the patient treated with ganciclovir or other antiviral treatment ? If not, this point has to be 
discussed. 
3/ Did the authors detect DNA-CMV by PCR on the liver biopsy ? 
4/ The authors state that the patient was immunocompetent. What were the explorations made ? 
------------------------------------------------------------------------------- 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research Level of interest: 
interests 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report 
 Acute partial Budd-Chiari syndrome and portal vein thrombosis in cytomegalovirus primary Title: 
infection: Case report 
 3  23 November 2005 Version: Date: 
 Jerome Dumortier Reviewer: 
Reviewer's report: 
Spahr and coll. report the case of a young woman who presented the association of a portal and 
hepatic vein thrombosis during an acute cytomegalovirus primoinfection with probable liver involvement. The paper is interesting because of the rarity of such complication of CMV infection. 
------------------------------------------------------------------------------- 
------------------------------------------------------------------------------- 
I have some comments on the case. 
1/ Did the authors explore the other causes of liver diseases, especially auto-immunity in this young 
woman ? Did histological examination exclude a pre-existing liver disease ? 
2/ Was the patient treated with ganciclovir or other antiviral treatment ? If not, this point has to be 
discussed. 
3/ Did the authors detect DNA-CMV by PCR on the liver biopsy ? 
4/ The authors state that the patient was immunocompetent. What were the explorations made ? 
------------------------------------------------------------------------------- 
 Accept after minor essential revisions What next?: 
 An article whose findings are important to those with closely related research Level of interest: 
interests 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests'
assistant