Title: Association of circulating tumor cell-white blood cell clusters with survival outcomes in
patients with colorectal cancer after curative intent surgery
Version: 1 Date: 15 Oct 2022
Reviewer:  Amirhossein Hessami
Reviewer's report:
The authors have reported the association of Circulating Tumor Cell-White Blood Cell (CTC-
WBC) clusters with outcomes of patients with colorectal cancer. In this article authors have
included two cohorts of patients undergone colorectal cancer surgery  which included CTC-only
and CTC-WBC patients. They have compared the progression free survival and overall survival
and factors affecting them in these two groups. The manuscript is novel and providing a very
good insight on the CTC-WBC use in clinical setting. While this is a single-center retrospective
cohort study, the authors have addressed the limitations and insight for future research. The
following comments could improve the manuscript further.
1- Please mention the advantage of using CTCs for monitoring response to therapy.
2- It is recommended to analyze and compare the data of patients in different CTC-WBC ranges
(which could help the further studies for determining a cut-off value).
Title: Association of circulating tumor cell-white blood cell clusters with survival outcomes in
patients with colorectal cancer after curative intent surgery
Version: 1 Date: 15 Oct 2022
Reviewer:  Amirhossein Hessami
Reviewer's report:
The authors have reported the association of Circulating Tumor Cell-White Blood Cell (CTC-
WBC) clusters with outcomes of patients with colorectal cancer. In this article authors have
included two cohorts of patients undergone colorectal cancer surgery  which included CTC-only
and CTC-WBC patients. They have compared the progression free survival and overall survival
and factors affecting them in these two groups. The manuscript is novel and providing a very
good insight on the CTC-WBC use in clinical setting. While this is a single-center retrospective
cohort study, the authors have addressed the limitations and insight for future research. The
following comments could improve the manuscript further.
1- Please mention the advantage of using CTCs for monitoring response to therapy.
2- It is recommended to analyze and compare the data of patients in different CTC-WBC ranges
(which could help the further studies for determining a cut-off value).
Please review this paper.
user
Title: Association of circulating tumor cell-white blood cell clusters with survival outcomes in
patients with colorectal cancer after curative intent surgery
Version: 1 Date: 15 Oct 2022
Reviewer:  Amirhossein Hessami
Reviewer's report:
The authors have reported the association of Circulating Tumor Cell-White Blood Cell (CTC-
WBC) clusters with outcomes of patients with colorectal cancer. In this article authors have
included two cohorts of patients undergone colorectal cancer surgery  which included CTC-only
and CTC-WBC patients. They have compared the progression free survival and overall survival
and factors affecting them in these two groups. The manuscript is novel and providing a very
good insight on the CTC-WBC use in clinical setting. While this is a single-center retrospective
cohort study, the authors have addressed the limitations and insight for future research. The
following comments could improve the manuscript further.
1- Please mention the advantage of using CTCs for monitoring response to therapy.
2- It is recommended to analyze and compare the data of patients in different CTC-WBC ranges
(which could help the further studies for determining a cut-off value).
assistant