Title: A Survey on Helicobacter pylori infection rate in Hainan Province and analysis of related
risk factors
Version: 3 Date: 22 Aug 2023
Reviewer's report:
The manuscript by Chen al aims to explore the prevalence and potential risk factors of
Helicobacter pylori infection in Hainan Province, China. This is an epidemiological status
survey on the prevalence of Helicobacter pylori infection, and the data presented in the
manuscript largely support their conclusion. This study has been of some value, the following
is a synopsis of concerns raised based on the data presented in the manuscript.
Major:
1) The methodology does not seem to mention the goodness-of-fit test of the model and
the predictive power of the model, please add this when available. E.g. Hosmer-Lemeshow
goodness-of-fit test and plotting of Receiver operating characteristic (ROC) curves can be
performed.
2) The authors mentioned "family history of gastric cancer" as a protective factor in both the
abstract and the results, which seems to be a surprising result. Such a result may lead to an
opposite conclusion to the previous one. In the discussion, the authors provide an explanation
for this. However, no clear data and previous literature were given to support this. In the cohort
of subjects included by the authors, what percentage of subjects with a family history of gastric
cancer received screening and eradication therapy? The authors are advised to be cautious in
their conclusions regarding this variable.
3) It is recommended that the inclusion criteria for the subjects of the study be described in
detail; the methodology in the manuscript does not elaborate on this section.
Some minor comments:
1) Bacterial names should be italicized. This applies to the Figure legends as much as anywhere
else.
2#In section "2.2 Questionnaire", what's the definition of BIM and is it BMI?
3) Section "2.4 Definition" seems to be consistent with some of the variable definitions in section
"2.2 Questionnaire", can they be effectively integrated?
4#Please note that all P-values need to be shown in italics.
5#What are the manifestations of "gastrointestinal symptoms", please add a description in the
appropriate section of the Methodology.
6) Manuscript should have a uniform paragraph format.
Title: A Survey on Helicobacter pylori infection rate in Hainan Province and analysis of related
risk factors
Version: 3 Date: 22 Aug 2023
Reviewer's report:
The manuscript by Chen al aims to explore the prevalence and potential risk factors of
Helicobacter pylori infection in Hainan Province, China. This is an epidemiological status
survey on the prevalence of Helicobacter pylori infection, and the data presented in the
manuscript largely support their conclusion. This study has been of some value, the following
is a synopsis of concerns raised based on the data presented in the manuscript.
Major:
1) The methodology does not seem to mention the goodness-of-fit test of the model and
the predictive power of the model, please add this when available. E.g. Hosmer-Lemeshow
goodness-of-fit test and plotting of Receiver operating characteristic (ROC) curves can be
performed.
2) The authors mentioned "family history of gastric cancer" as a protective factor in both the
abstract and the results, which seems to be a surprising result. Such a result may lead to an
opposite conclusion to the previous one. In the discussion, the authors provide an explanation
for this. However, no clear data and previous literature were given to support this. In the cohort
of subjects included by the authors, what percentage of subjects with a family history of gastric
cancer received screening and eradication therapy? The authors are advised to be cautious in
their conclusions regarding this variable.
3) It is recommended that the inclusion criteria for the subjects of the study be described in
detail; the methodology in the manuscript does not elaborate on this section.
Some minor comments:
1) Bacterial names should be italicized. This applies to the Figure legends as much as anywhere
else.
2#In section "2.2 Questionnaire", what's the definition of BIM and is it BMI?
3) Section "2.4 Definition" seems to be consistent with some of the variable definitions in section
"2.2 Questionnaire", can they be effectively integrated?
4#Please note that all P-values need to be shown in italics.
5#What are the manifestations of "gastrointestinal symptoms", please add a description in the
appropriate section of the Methodology.
6) Manuscript should have a uniform paragraph format.
Please review this paper.
user
Title: A Survey on Helicobacter pylori infection rate in Hainan Province and analysis of related
risk factors
Version: 3 Date: 22 Aug 2023
Reviewer's report:
The manuscript by Chen al aims to explore the prevalence and potential risk factors of
Helicobacter pylori infection in Hainan Province, China. This is an epidemiological status
survey on the prevalence of Helicobacter pylori infection, and the data presented in the
manuscript largely support their conclusion. This study has been of some value, the following
is a synopsis of concerns raised based on the data presented in the manuscript.
Major:
1) The methodology does not seem to mention the goodness-of-fit test of the model and
the predictive power of the model, please add this when available. E.g. Hosmer-Lemeshow
goodness-of-fit test and plotting of Receiver operating characteristic (ROC) curves can be
performed.
2) The authors mentioned "family history of gastric cancer" as a protective factor in both the
abstract and the results, which seems to be a surprising result. Such a result may lead to an
opposite conclusion to the previous one. In the discussion, the authors provide an explanation
for this. However, no clear data and previous literature were given to support this. In the cohort
of subjects included by the authors, what percentage of subjects with a family history of gastric
cancer received screening and eradication therapy? The authors are advised to be cautious in
their conclusions regarding this variable.
3) It is recommended that the inclusion criteria for the subjects of the study be described in
detail; the methodology in the manuscript does not elaborate on this section.
Some minor comments:
1) Bacterial names should be italicized. This applies to the Figure legends as much as anywhere
else.
2#In section "2.2 Questionnaire", what's the definition of BIM and is it BMI?
3) Section "2.4 Definition" seems to be consistent with some of the variable definitions in section
"2.2 Questionnaire", can they be effectively integrated?
4#Please note that all P-values need to be shown in italics.
5#What are the manifestations of "gastrointestinal symptoms", please add a description in the
appropriate section of the Methodology.
6) Manuscript should have a uniform paragraph format.
assistant