Reviewer's report
Title:Esophageal peristaltic dysfunction in asthma is likely to be secondary to
increased gastro-esophageal reflux.
Version: 2Date:18 March 2012
Reviewer: Reginald V. Lord
Reviewer's report:
Review of “Esophageal peristaltic dysfunction in asthma is likely to be secondary
to increased gastro-esophageal reflux” by D Lakmali Amarasiri et al.
The study is well conducted and the manuscript is very well written. The
Discussion section is comprehensive. The study is not especially novel, as it is
well known that asthmatics have a high prevalence of GERD, esophageal
dysmotility, and hypervagal response. It may be wondered whether the
bronchospasm in some of the patients in this series did not have GERD as their
primary pathology, with the asthma secondary to reflux. This could be discussed
by the authors.
Were the control patients significantly different in terms of age, sex? Younger
individuals are less likely to have GERD and it can be tempting to enrol the
medical students etc. for these studies.
The rate of equipment failure during the esophageal manometry studies is high –
11 patients or individuals.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Esophageal peristaltic dysfunction in asthma is likely to be secondary to
increased gastro-esophageal reflux.
Version: 2Date:18 March 2012
Reviewer: Reginald V. Lord
Reviewer's report:
Review of “Esophageal peristaltic dysfunction in asthma is likely to be secondary
to increased gastro-esophageal reflux” by D Lakmali Amarasiri et al.
The study is well conducted and the manuscript is very well written. The
Discussion section is comprehensive. The study is not especially novel, as it is
well known that asthmatics have a high prevalence of GERD, esophageal
dysmotility, and hypervagal response. It may be wondered whether the
bronchospasm in some of the patients in this series did not have GERD as their
primary pathology, with the asthma secondary to reflux. This could be discussed
by the authors.
Were the control patients significantly different in terms of age, sex? Younger
individuals are less likely to have GERD and it can be tempting to enrol the
medical students etc. for these studies.
The rate of equipment failure during the esophageal manometry studies is high –
11 patients or individuals.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Esophageal peristaltic dysfunction in asthma is likely to be secondary to
increased gastro-esophageal reflux.
Version: 2Date:18 March 2012
Reviewer: Reginald V. Lord
Reviewer's report:
Review of “Esophageal peristaltic dysfunction in asthma is likely to be secondary
to increased gastro-esophageal reflux” by D Lakmali Amarasiri et al.
The study is well conducted and the manuscript is very well written. The
Discussion section is comprehensive. The study is not especially novel, as it is
well known that asthmatics have a high prevalence of GERD, esophageal
dysmotility, and hypervagal response. It may be wondered whether the
bronchospasm in some of the patients in this series did not have GERD as their
primary pathology, with the asthma secondary to reflux. This could be discussed
by the authors.
Were the control patients significantly different in terms of age, sex? Younger
individuals are less likely to have GERD and it can be tempting to enrol the
medical students etc. for these studies.
The rate of equipment failure during the esophageal manometry studies is high –
11 patients or individuals.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant