Title: Risk factors for pathological upgrading and noncurative resection in patients with gastric
mucosal lesions after endoscopic submucosal dissection
Version: 2 Date: 02 Jul 2024
Reviewer's report:
The authors have revised a manuscript entitled " Risk factors for pathological upgrading and
noncurative resection in patients with gastric mucosal lesions after endoscopic submucosal
dissection". The point-by-point responses to the reviewers' comments were mostly accepted.
However, there is some concern to be addressed for publication.
1. Abstract:
For the first abbreviations, "EGC" and "GIN", the correct full spelling should be written.
2. Materials and Methods :
#P8 line 173-178 “Ensure that the patient has ~ after anesthesia.”
#P9 line 187-188 “After the process, the endoscope was gradually removed to finish the
examination.”
#P10 line 226-228 “If the lesion is ~ , it is separated anally.”
#P10 line 223-225 “The solution was injected ~ for this change.”
# I don’t think this sentence is necessary.
#P9 line 203 “~ to assess the depth of tumor invasion”
# I think endoscopic ultrasonography is usually used to assess the depth of tumor invasion.
Contrast-enhanced CT of the abdomen would be used to evaluate lymph nodes and distant
metastases.
3. Results :
#P15 line 322-323 “intramucosal IC” # intramucosal carcinoma?
#P16 line 351-352 “Most of these risk factors are ~ noncurative resection.”
# I don’t think you can mention so much from Table 4.
#P17 line 379-388, and Table 7.
# Isn't this sentence and Table 7 almost identical to lines 362-378 and Table 6?
Because you analyzed multivariate logistic regression analysis about noncurative resection, I
think this sentence and table 7 are unnecessary.
4. Discussion:
P22 line 480-481. “Consequently, poorly ~ the surrounding mucosa.”
# You said “There was a greater rate of submucosal infiltration in undifferentiated malignancies
than in differentiated cancers.”
And table 7 show no undifferentiated malignancies are horizontal margin positive.
Therefore, I think you cannot say so much like line 480-481.
Title: Risk factors for pathological upgrading and noncurative resection in patients with gastric
mucosal lesions after endoscopic submucosal dissection
Version: 2 Date: 02 Jul 2024
Reviewer's report:
The authors have revised a manuscript entitled " Risk factors for pathological upgrading and
noncurative resection in patients with gastric mucosal lesions after endoscopic submucosal
dissection". The point-by-point responses to the reviewers' comments were mostly accepted.
However, there is some concern to be addressed for publication.
1. Abstract:
For the first abbreviations, "EGC" and "GIN", the correct full spelling should be written.
2. Materials and Methods :
#P8 line 173-178 “Ensure that the patient has ~ after anesthesia.”
#P9 line 187-188 “After the process, the endoscope was gradually removed to finish the
examination.”
#P10 line 226-228 “If the lesion is ~ , it is separated anally.”
#P10 line 223-225 “The solution was injected ~ for this change.”
# I don’t think this sentence is necessary.
#P9 line 203 “~ to assess the depth of tumor invasion”
# I think endoscopic ultrasonography is usually used to assess the depth of tumor invasion.
Contrast-enhanced CT of the abdomen would be used to evaluate lymph nodes and distant
metastases.
3. Results :
#P15 line 322-323 “intramucosal IC” # intramucosal carcinoma?
#P16 line 351-352 “Most of these risk factors are ~ noncurative resection.”
# I don’t think you can mention so much from Table 4.
#P17 line 379-388, and Table 7.
# Isn't this sentence and Table 7 almost identical to lines 362-378 and Table 6?
Because you analyzed multivariate logistic regression analysis about noncurative resection, I
think this sentence and table 7 are unnecessary.
4. Discussion:
P22 line 480-481. “Consequently, poorly ~ the surrounding mucosa.”
# You said “There was a greater rate of submucosal infiltration in undifferentiated malignancies
than in differentiated cancers.”
And table 7 show no undifferentiated malignancies are horizontal margin positive.
Therefore, I think you cannot say so much like line 480-481.
Please review this paper.
user
Title: Risk factors for pathological upgrading and noncurative resection in patients with gastric
mucosal lesions after endoscopic submucosal dissection
Version: 2 Date: 02 Jul 2024
Reviewer's report:
The authors have revised a manuscript entitled " Risk factors for pathological upgrading and
noncurative resection in patients with gastric mucosal lesions after endoscopic submucosal
dissection". The point-by-point responses to the reviewers' comments were mostly accepted.
However, there is some concern to be addressed for publication.
1. Abstract:
For the first abbreviations, "EGC" and "GIN", the correct full spelling should be written.
2. Materials and Methods :
#P8 line 173-178 “Ensure that the patient has ~ after anesthesia.”
#P9 line 187-188 “After the process, the endoscope was gradually removed to finish the
examination.”
#P10 line 226-228 “If the lesion is ~ , it is separated anally.”
#P10 line 223-225 “The solution was injected ~ for this change.”
# I don’t think this sentence is necessary.
#P9 line 203 “~ to assess the depth of tumor invasion”
# I think endoscopic ultrasonography is usually used to assess the depth of tumor invasion.
Contrast-enhanced CT of the abdomen would be used to evaluate lymph nodes and distant
metastases.
3. Results :
#P15 line 322-323 “intramucosal IC” # intramucosal carcinoma?
#P16 line 351-352 “Most of these risk factors are ~ noncurative resection.”
# I don’t think you can mention so much from Table 4.
#P17 line 379-388, and Table 7.
# Isn't this sentence and Table 7 almost identical to lines 362-378 and Table 6?
Because you analyzed multivariate logistic regression analysis about noncurative resection, I
think this sentence and table 7 are unnecessary.
4. Discussion:
P22 line 480-481. “Consequently, poorly ~ the surrounding mucosa.”
# You said “There was a greater rate of submucosal infiltration in undifferentiated malignancies
than in differentiated cancers.”
And table 7 show no undifferentiated malignancies are horizontal margin positive.
Therefore, I think you cannot say so much like line 480-481.
assistant