Reviewer's report
Title:Early effects of oral administration of lafutidine with mosapride compared
with lafutidine alone on intragastric pH values
Version: 1Date:17 March 2009
Reviewer: Spiros Ladas
Reviewer's report:
In this study Iida et al compare the effect of the co-administration of an H-2
receptor antagonist (lafutidine) and a prokinetic (mosapride) versus the
administration of the H-2 receptor antagonist alone, on the intragastric pH during
the immediate post-administration period. The hypothesis to test is that the
co-administration of the prokinetic would accelerate the absorption of the H-2
antagonist by accelerating gastric emptying resulting in a more rapid and
effective on-demand therapy for GERD.
Major Compulsory Revisions
In the introduction (line 9) the authors state that their study was aiming to
examine whether H2RA + mosapride could more rapidly increase intragastric pH.
This is repeated in the Discussion (page 9, lines 10 and 15-16). However, they
have not measured the time elapsed since the administration of the drug(s) for
intragastric pH to increase above a certain pH, e.g. 4, 5 or 6.
Minor Essential Revisions
1. The authors comment that the combined administration of lafutidine and
mosapride could be an effective on-demand therapy for GERD. However, they
have studied healthy volunteers and not GERD patients requiring on-demand
therapy. They should, therefore, comment on this in the discussion section.
2. In the Background page 4) the authors comment about gastric ulcer
haemorrhage and gastric pH. This is not relevant with study and should be
omitted (lines 1-4)
3. The authors may wish to refer and comment on a recently published study on
the same topic (Dig Dis Sci. 2008;53:3128-32)
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Early effects of oral administration of lafutidine with mosapride compared
with lafutidine alone on intragastric pH values
Version: 1Date:17 March 2009
Reviewer: Spiros Ladas
Reviewer's report:
In this study Iida et al compare the effect of the co-administration of an H-2
receptor antagonist (lafutidine) and a prokinetic (mosapride) versus the
administration of the H-2 receptor antagonist alone, on the intragastric pH during
the immediate post-administration period. The hypothesis to test is that the
co-administration of the prokinetic would accelerate the absorption of the H-2
antagonist by accelerating gastric emptying resulting in a more rapid and
effective on-demand therapy for GERD.
Major Compulsory Revisions
In the introduction (line 9) the authors state that their study was aiming to
examine whether H2RA + mosapride could more rapidly increase intragastric pH.
This is repeated in the Discussion (page 9, lines 10 and 15-16). However, they
have not measured the time elapsed since the administration of the drug(s) for
intragastric pH to increase above a certain pH, e.g. 4, 5 or 6.
Minor Essential Revisions
1. The authors comment that the combined administration of lafutidine and
mosapride could be an effective on-demand therapy for GERD. However, they
have studied healthy volunteers and not GERD patients requiring on-demand
therapy. They should, therefore, comment on this in the discussion section.
2. In the Background page 4) the authors comment about gastric ulcer
haemorrhage and gastric pH. This is not relevant with study and should be
omitted (lines 1-4)
3. The authors may wish to refer and comment on a recently published study on
the same topic (Dig Dis Sci. 2008;53:3128-32)
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Early effects of oral administration of lafutidine with mosapride compared
with lafutidine alone on intragastric pH values
Version: 1Date:17 March 2009
Reviewer: Spiros Ladas
Reviewer's report:
In this study Iida et al compare the effect of the co-administration of an H-2
receptor antagonist (lafutidine) and a prokinetic (mosapride) versus the
administration of the H-2 receptor antagonist alone, on the intragastric pH during
the immediate post-administration period. The hypothesis to test is that the
co-administration of the prokinetic would accelerate the absorption of the H-2
antagonist by accelerating gastric emptying resulting in a more rapid and
effective on-demand therapy for GERD.
Major Compulsory Revisions
In the introduction (line 9) the authors state that their study was aiming to
examine whether H2RA + mosapride could more rapidly increase intragastric pH.
This is repeated in the Discussion (page 9, lines 10 and 15-16). However, they
have not measured the time elapsed since the administration of the drug(s) for
intragastric pH to increase above a certain pH, e.g. 4, 5 or 6.
Minor Essential Revisions
1. The authors comment that the combined administration of lafutidine and
mosapride could be an effective on-demand therapy for GERD. However, they
have studied healthy volunteers and not GERD patients requiring on-demand
therapy. They should, therefore, comment on this in the discussion section.
2. In the Background page 4) the authors comment about gastric ulcer
haemorrhage and gastric pH. This is not relevant with study and should be
omitted (lines 1-4)
3. The authors may wish to refer and comment on a recently published study on
the same topic (Dig Dis Sci. 2008;53:3128-32)
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant