Title: Young adults with colon cancer: clinical features and surgical outcomes
Version: 0 Date: 10 Dec 2022
Reviewer:  Zi-ye Zhao
Reviewer's report:
I am very glad to see a study on early onset colon cancer. Through their analysis, the authors
found that colon cancers occurred in young people is essentially not a different type of cancer
from those occurred in seniors. But I think the flaws of both samples and methods compromised
the points that the authors wanted to make.
1. The total number of cases involved in this study is only seventy, so I think the results out of
this group of patients are obvious labile. Even if the authors’ opinion is remarkable and correct,
the data here cannot support it thoroughly.
2. The linear regression without a significant result cannot support the idea that no significant
rising trend of early onset colon cancer in the past 8 years. It can only indicate there is not a
linear rising trend. The corresponding explanations in the manuscript are wrong, including the
meaning of the P value and the judgment of the trend.
3. In the methods part, the exclusion criteria are not comprehensive. As to the hereditary CRC
syndrome, why is FAP the only disease being excluded? How about other intestinal polyposis?
4. In the first paragraph of the discussion part, the authors concluded that colon cancer in
young- onset adults was not special. The expression is strange, so the manuscript may need a
thorough language polishing. And authors seem not put forward the data of CRC in seniors as
the references to prove the non-specificity.
Title: Young adults with colon cancer: clinical features and surgical outcomes
Version: 0 Date: 10 Dec 2022
Reviewer:  Zi-ye Zhao
Reviewer's report:
I am very glad to see a study on early onset colon cancer. Through their analysis, the authors
found that colon cancers occurred in young people is essentially not a different type of cancer
from those occurred in seniors. But I think the flaws of both samples and methods compromised
the points that the authors wanted to make.
1. The total number of cases involved in this study is only seventy, so I think the results out of
this group of patients are obvious labile. Even if the authors’ opinion is remarkable and correct,
the data here cannot support it thoroughly.
2. The linear regression without a significant result cannot support the idea that no significant
rising trend of early onset colon cancer in the past 8 years. It can only indicate there is not a
linear rising trend. The corresponding explanations in the manuscript are wrong, including the
meaning of the P value and the judgment of the trend.
3. In the methods part, the exclusion criteria are not comprehensive. As to the hereditary CRC
syndrome, why is FAP the only disease being excluded? How about other intestinal polyposis?
4. In the first paragraph of the discussion part, the authors concluded that colon cancer in
young- onset adults was not special. The expression is strange, so the manuscript may need a
thorough language polishing. And authors seem not put forward the data of CRC in seniors as
the references to prove the non-specificity.
Please review this paper.
user
Title: Young adults with colon cancer: clinical features and surgical outcomes
Version: 0 Date: 10 Dec 2022
Reviewer:  Zi-ye Zhao
Reviewer's report:
I am very glad to see a study on early onset colon cancer. Through their analysis, the authors
found that colon cancers occurred in young people is essentially not a different type of cancer
from those occurred in seniors. But I think the flaws of both samples and methods compromised
the points that the authors wanted to make.
1. The total number of cases involved in this study is only seventy, so I think the results out of
this group of patients are obvious labile. Even if the authors’ opinion is remarkable and correct,
the data here cannot support it thoroughly.
2. The linear regression without a significant result cannot support the idea that no significant
rising trend of early onset colon cancer in the past 8 years. It can only indicate there is not a
linear rising trend. The corresponding explanations in the manuscript are wrong, including the
meaning of the P value and the judgment of the trend.
3. In the methods part, the exclusion criteria are not comprehensive. As to the hereditary CRC
syndrome, why is FAP the only disease being excluded? How about other intestinal polyposis?
4. In the first paragraph of the discussion part, the authors concluded that colon cancer in
young- onset adults was not special. The expression is strange, so the manuscript may need a
thorough language polishing. And authors seem not put forward the data of CRC in seniors as
the references to prove the non-specificity.
assistant