Title: Adenocarcinoma of the esophagogastric junction: characteristics of female patients
and young adult patients based on a 12-year retrospective and prospective multicenter
clinicoepidemiological cohort study in Japan
Version: 5 Date: 28 Aug 2024
Reviewer:  Elfriede Bollschweiler
Reviewer's report:
According to my opinion this manuscript is of interest for the reader of BMC Gastroenterology.
Explain this by the main points:
1. This is a prospective study, only the follow-up was retrospective collected.
2. The data are from a defined region, therefore  the selection bias is minimized.
3. Adenocarcinoma of the gastrointestinal junction are not so often seen in East
Asia compared to Western region.  Results from Japan for this tumour are rare. To compare data
from East and West these data are of interest.
4. The follow-up seems to be easier and as a consequence more exact according to the reasons
of death.
Of course, there may be some problems:
- small number of patients, especially in the subgroups
- non-significance may be caused by this fact.
- the description of the main findings are difficult, and so on.
My conclusion, the paper is of interest
I have two additional remarks:
1. Please,  add to the tables the therapeutic procedure for the tumor
e.g. Endoscopic - EMR or ESD
Surgery: Esophagectomy or Gastrectomy.
and a description of the main  procedures in the part "material and methods"
2. Please add a calculation of the overall survival
Title: Adenocarcinoma of the esophagogastric junction: characteristics of female patients
and young adult patients based on a 12-year retrospective and prospective multicenter
clinicoepidemiological cohort study in Japan
Version: 5 Date: 28 Aug 2024
Reviewer:  Elfriede Bollschweiler
Reviewer's report:
According to my opinion this manuscript is of interest for the reader of BMC Gastroenterology.
Explain this by the main points:
1. This is a prospective study, only the follow-up was retrospective collected.
2. The data are from a defined region, therefore  the selection bias is minimized.
3. Adenocarcinoma of the gastrointestinal junction are not so often seen in East
Asia compared to Western region.  Results from Japan for this tumour are rare. To compare data
from East and West these data are of interest.
4. The follow-up seems to be easier and as a consequence more exact according to the reasons
of death.
Of course, there may be some problems:
- small number of patients, especially in the subgroups
- non-significance may be caused by this fact.
- the description of the main findings are difficult, and so on.
My conclusion, the paper is of interest
I have two additional remarks:
1. Please,  add to the tables the therapeutic procedure for the tumor
e.g. Endoscopic - EMR or ESD
Surgery: Esophagectomy or Gastrectomy.
and a description of the main  procedures in the part "material and methods"
2. Please add a calculation of the overall survival
Please review this paper.
user
Title: Adenocarcinoma of the esophagogastric junction: characteristics of female patients
and young adult patients based on a 12-year retrospective and prospective multicenter
clinicoepidemiological cohort study in Japan
Version: 5 Date: 28 Aug 2024
Reviewer:  Elfriede Bollschweiler
Reviewer's report:
According to my opinion this manuscript is of interest for the reader of BMC Gastroenterology.
Explain this by the main points:
1. This is a prospective study, only the follow-up was retrospective collected.
2. The data are from a defined region, therefore  the selection bias is minimized.
3. Adenocarcinoma of the gastrointestinal junction are not so often seen in East
Asia compared to Western region.  Results from Japan for this tumour are rare. To compare data
from East and West these data are of interest.
4. The follow-up seems to be easier and as a consequence more exact according to the reasons
of death.
Of course, there may be some problems:
- small number of patients, especially in the subgroups
- non-significance may be caused by this fact.
- the description of the main findings are difficult, and so on.
My conclusion, the paper is of interest
I have two additional remarks:
1. Please,  add to the tables the therapeutic procedure for the tumor
e.g. Endoscopic - EMR or ESD
Surgery: Esophagectomy or Gastrectomy.
and a description of the main  procedures in the part "material and methods"
2. Please add a calculation of the overall survival
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