Reviewer's report
Title:Influence of acute pancreatitis on the responsiveness of rat mesenteric and
pulmonary arteries
Version: 1Date:26 February 2008
Reviewer: Jean-Louis Frossard
Reviewer's report:
The paper by Camargo et al is aimed at evaluating the influence of acute
pancreatitis on the responsiveness of rat mesenteric and pulmonary arteries. The
authors used the well known model of taurocholate induced acute pancreatitis
and presented their data in two main figures. They found minor changes
(although some are significantly different from control groups) in the dose
response curves using Ach, Phe and SNP as pharmacological agents.
Several points deserve comments.
Major points:
The authors do not demonstrate how severe the pancreatitis was in the rat. They
must give amylase or lipase concentrations in all groups, and show others
parameters that are usually used to illustrate the occurrence of pancreatitis
(pancreatic edema, pancreatic necrosis, sequestration of inflammatory cells
within the pancreas).
They focus on a very pivotal remote organ injury studying the lung during acute
pancreatitis. The data provided in this study add minor incremental new data and
even if some of the results brought by the authors are statistically different in
figure 1 from control treated animals, it does not mean to me at least anything
relevant.
The nitrite/nitrate data are not new.
Altogether the paper does not bring important new data.
What next?: Reject because scientifically unsound
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Influence of acute pancreatitis on the responsiveness of rat mesenteric and
pulmonary arteries
Version: 1Date:26 February 2008
Reviewer: Jean-Louis Frossard
Reviewer's report:
The paper by Camargo et al is aimed at evaluating the influence of acute
pancreatitis on the responsiveness of rat mesenteric and pulmonary arteries. The
authors used the well known model of taurocholate induced acute pancreatitis
and presented their data in two main figures. They found minor changes
(although some are significantly different from control groups) in the dose
response curves using Ach, Phe and SNP as pharmacological agents.
Several points deserve comments.
Major points:
The authors do not demonstrate how severe the pancreatitis was in the rat. They
must give amylase or lipase concentrations in all groups, and show others
parameters that are usually used to illustrate the occurrence of pancreatitis
(pancreatic edema, pancreatic necrosis, sequestration of inflammatory cells
within the pancreas).
They focus on a very pivotal remote organ injury studying the lung during acute
pancreatitis. The data provided in this study add minor incremental new data and
even if some of the results brought by the authors are statistically different in
figure 1 from control treated animals, it does not mean to me at least anything
relevant.
The nitrite/nitrate data are not new.
Altogether the paper does not bring important new data.
What next?: Reject because scientifically unsound
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Influence of acute pancreatitis on the responsiveness of rat mesenteric and
pulmonary arteries
Version: 1Date:26 February 2008
Reviewer: Jean-Louis Frossard
Reviewer's report:
The paper by Camargo et al is aimed at evaluating the influence of acute
pancreatitis on the responsiveness of rat mesenteric and pulmonary arteries. The
authors used the well known model of taurocholate induced acute pancreatitis
and presented their data in two main figures. They found minor changes
(although some are significantly different from control groups) in the dose
response curves using Ach, Phe and SNP as pharmacological agents.
Several points deserve comments.
Major points:
The authors do not demonstrate how severe the pancreatitis was in the rat. They
must give amylase or lipase concentrations in all groups, and show others
parameters that are usually used to illustrate the occurrence of pancreatitis
(pancreatic edema, pancreatic necrosis, sequestration of inflammatory cells
within the pancreas).
They focus on a very pivotal remote organ injury studying the lung during acute
pancreatitis. The data provided in this study add minor incremental new data and
even if some of the results brought by the authors are statistically different in
figure 1 from control treated animals, it does not mean to me at least anything
relevant.
The nitrite/nitrate data are not new.
Altogether the paper does not bring important new data.
What next?: Reject because scientifically unsound
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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