Reviewer's report
Title:Dome-type Carcinoma of the Colon; A Rare Variant of Adenocarcinoma
Resembling a Submucosal Tumor: a case report
Version: 3Date:15 December 2011
Reviewer: Susanne Holck
Reviewer's report:
Yamada et al provide a beautifully illustrated example of dome carcinoma. Its
publication can be recommended as a reminder to the GI-pathologists of the
existence of this unique variant of colorectal carcinoma. Dome carcinoma has
been the subject of merely a handful of case reports since its introduction to the
literature in 2000. Noteworthy, this tumour was not included in the most recent
edition of the WHO Classification of Tumours of the Digestive System.
At variance with the few previously reported cases, the present one has retained
the unique histological attributes, including the prominent lymphoid tissue,
despite its high pT-stage. Since this is not always the case, its correct
classification relies on a high diagnostic acumen on the part of the pathologist.
With the advent of screening for colorectal neoplasms that implies the
identification of lower cancer stages, more likely to retain the characteristic
qualities, more such cases may be identified.
Thereby, data on the molecular pathology aspects and issues concerning
carcinogenesis, specifically the role of M-cells and the accompanying lymphoid
component may be provided.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Dome-type Carcinoma of the Colon; A Rare Variant of Adenocarcinoma
Resembling a Submucosal Tumor: a case report
Version: 3Date:15 December 2011
Reviewer: Susanne Holck
Reviewer's report:
Yamada et al provide a beautifully illustrated example of dome carcinoma. Its
publication can be recommended as a reminder to the GI-pathologists of the
existence of this unique variant of colorectal carcinoma. Dome carcinoma has
been the subject of merely a handful of case reports since its introduction to the
literature in 2000. Noteworthy, this tumour was not included in the most recent
edition of the WHO Classification of Tumours of the Digestive System.
At variance with the few previously reported cases, the present one has retained
the unique histological attributes, including the prominent lymphoid tissue,
despite its high pT-stage. Since this is not always the case, its correct
classification relies on a high diagnostic acumen on the part of the pathologist.
With the advent of screening for colorectal neoplasms that implies the
identification of lower cancer stages, more likely to retain the characteristic
qualities, more such cases may be identified.
Thereby, data on the molecular pathology aspects and issues concerning
carcinogenesis, specifically the role of M-cells and the accompanying lymphoid
component may be provided.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Dome-type Carcinoma of the Colon; A Rare Variant of Adenocarcinoma
Resembling a Submucosal Tumor: a case report
Version: 3Date:15 December 2011
Reviewer: Susanne Holck
Reviewer's report:
Yamada et al provide a beautifully illustrated example of dome carcinoma. Its
publication can be recommended as a reminder to the GI-pathologists of the
existence of this unique variant of colorectal carcinoma. Dome carcinoma has
been the subject of merely a handful of case reports since its introduction to the
literature in 2000. Noteworthy, this tumour was not included in the most recent
edition of the WHO Classification of Tumours of the Digestive System.
At variance with the few previously reported cases, the present one has retained
the unique histological attributes, including the prominent lymphoid tissue,
despite its high pT-stage. Since this is not always the case, its correct
classification relies on a high diagnostic acumen on the part of the pathologist.
With the advent of screening for colorectal neoplasms that implies the
identification of lower cancer stages, more likely to retain the characteristic
qualities, more such cases may be identified.
Thereby, data on the molecular pathology aspects and issues concerning
carcinogenesis, specifically the role of M-cells and the accompanying lymphoid
component may be provided.
Declaration of competing interests:
'I declare that I have no competing interests'
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