Reviewer's report
Title:Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4
serum levels, in patients with inflammatory bowel disease
Version: 1Date:31 March 2008
Reviewer: N Yoshida
Reviewer's report:
In this study, authors demonstrate the importance of serum levels of TMP-1 and
–4 in the patients with IBD. In the clinical field, it is very important to detect the
marker of the activity in IBD patients. As the authors conclude that the TIMP-1
serum levels may be a useful marker of disease activity in IBD, this paper
includes very important and interesting points.
Major points
1. In this study, serum TIMP-2 levels have no statistically significant difference
between IBD patients and HC. So the authors do not have to show “figure 2”;
serum TIMP-2 data.
2. In this study, the author should show the importance of serum TIMP-1 levels
which is correlated with the activity of IBD. They determined that TIMP-1 levels
are significantly higher in patients with active IBD as compared with patients with
inactive disease. This data should be much more important than figure 2; serum
TIMP-2 data.
No minor points are detected.
Reviewer's report
Title:Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4
serum levels, in patients with inflammatory bowel disease
Version: 1Date:31 March 2008
Reviewer: N Yoshida
Reviewer's report:
In this study, authors demonstrate the importance of serum levels of TMP-1 and
–4 in the patients with IBD. In the clinical field, it is very important to detect the
marker of the activity in IBD patients. As the authors conclude that the TIMP-1
serum levels may be a useful marker of disease activity in IBD, this paper
includes very important and interesting points.
Major points
1. In this study, serum TIMP-2 levels have no statistically significant difference
between IBD patients and HC. So the authors do not have to show “figure 2”;
serum TIMP-2 data.
2. In this study, the author should show the importance of serum TIMP-1 levels
which is correlated with the activity of IBD. They determined that TIMP-1 levels
are significantly higher in patients with active IBD as compared with patients with
inactive disease. This data should be much more important than figure 2; serum
TIMP-2 data.
No minor points are detected.
Please review this paper.
user
Reviewer's report
Title:Imbalance of tissue inhibitors of metalloproteinases (TIMP) - 1 and - 4
serum levels, in patients with inflammatory bowel disease
Version: 1Date:31 March 2008
Reviewer: N Yoshida
Reviewer's report:
In this study, authors demonstrate the importance of serum levels of TMP-1 and
–4 in the patients with IBD. In the clinical field, it is very important to detect the
marker of the activity in IBD patients. As the authors conclude that the TIMP-1
serum levels may be a useful marker of disease activity in IBD, this paper
includes very important and interesting points.
Major points
1. In this study, serum TIMP-2 levels have no statistically significant difference
between IBD patients and HC. So the authors do not have to show “figure 2”;
serum TIMP-2 data.
2. In this study, the author should show the importance of serum TIMP-1 levels
which is correlated with the activity of IBD. They determined that TIMP-1 levels
are significantly higher in patients with active IBD as compared with patients with
inactive disease. This data should be much more important than figure 2; serum
TIMP-2 data.
No minor points are detected.
assistant