Title: The Prognostic Value of Systemic Inflammation Response Index in Digestive System
Carcinomas: A Systematic Review and Meta-Analysis
Version: 4 Date: 19 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-A brief section on the mechanistic pathways through which inflammation contributes to cancer
progression, particularly in the context of DSC, would enhance the depth of the introduction.
This would also help to better justify the clinical relevance of SIRI.
-Acknowledging the limitation of restricting to English-language studies and discussing its
potential impact on the results would add transparency and allow readers to consider this factor
when interpreting the findings.
-While the discussion provides an overview of the roles of immune cells in cancer progression,
further exploration of the molecular mechanisms behind SIRI’s predictive value could provide
more clarity. For example, linking SIRI to specific inflammatory cytokines, immune pathways,
or tumor microenvironment changes would help strengthen the biological plausibility of the
findings.
-The authors should discuss how different cut-off values for SIRI might impact its prognostic
accuracy. What are the implications of using an "optimal" cut-off, and how does it vary across
different cancers or treatment regimens?
-While the potential clinical applications of SIRI are mentioned, the discussion could benefit
from specific examples of how SIRI could be integrated into clinical practice. For example,
could it be used as a screening tool for identifying high-risk DSC patients, or could it help guide
decisions regarding treatment intensification or de-escalation?
-The authors could expand on how publication bias might affect their findings, and discuss the
implications of this bias in more detail. Could alternative methods for addressing publication
bias (e.g., sensitivity analyses for negative studies or gray literature) further strengthen the
conclusions?
Title: The Prognostic Value of Systemic Inflammation Response Index in Digestive System
Carcinomas: A Systematic Review and Meta-Analysis
Version: 4 Date: 19 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-A brief section on the mechanistic pathways through which inflammation contributes to cancer
progression, particularly in the context of DSC, would enhance the depth of the introduction.
This would also help to better justify the clinical relevance of SIRI.
-Acknowledging the limitation of restricting to English-language studies and discussing its
potential impact on the results would add transparency and allow readers to consider this factor
when interpreting the findings.
-While the discussion provides an overview of the roles of immune cells in cancer progression,
further exploration of the molecular mechanisms behind SIRI’s predictive value could provide
more clarity. For example, linking SIRI to specific inflammatory cytokines, immune pathways,
or tumor microenvironment changes would help strengthen the biological plausibility of the
findings.
-The authors should discuss how different cut-off values for SIRI might impact its prognostic
accuracy. What are the implications of using an "optimal" cut-off, and how does it vary across
different cancers or treatment regimens?
-While the potential clinical applications of SIRI are mentioned, the discussion could benefit
from specific examples of how SIRI could be integrated into clinical practice. For example,
could it be used as a screening tool for identifying high-risk DSC patients, or could it help guide
decisions regarding treatment intensification or de-escalation?
-The authors could expand on how publication bias might affect their findings, and discuss the
implications of this bias in more detail. Could alternative methods for addressing publication
bias (e.g., sensitivity analyses for negative studies or gray literature) further strengthen the
conclusions?
Please review this paper.
user
Title: The Prognostic Value of Systemic Inflammation Response Index in Digestive System
Carcinomas: A Systematic Review and Meta-Analysis
Version: 4 Date: 19 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-A brief section on the mechanistic pathways through which inflammation contributes to cancer
progression, particularly in the context of DSC, would enhance the depth of the introduction.
This would also help to better justify the clinical relevance of SIRI.
-Acknowledging the limitation of restricting to English-language studies and discussing its
potential impact on the results would add transparency and allow readers to consider this factor
when interpreting the findings.
-While the discussion provides an overview of the roles of immune cells in cancer progression,
further exploration of the molecular mechanisms behind SIRI’s predictive value could provide
more clarity. For example, linking SIRI to specific inflammatory cytokines, immune pathways,
or tumor microenvironment changes would help strengthen the biological plausibility of the
findings.
-The authors should discuss how different cut-off values for SIRI might impact its prognostic
accuracy. What are the implications of using an "optimal" cut-off, and how does it vary across
different cancers or treatment regimens?
-While the potential clinical applications of SIRI are mentioned, the discussion could benefit
from specific examples of how SIRI could be integrated into clinical practice. For example,
could it be used as a screening tool for identifying high-risk DSC patients, or could it help guide
decisions regarding treatment intensification or de-escalation?
-The authors could expand on how publication bias might affect their findings, and discuss the
implications of this bias in more detail. Could alternative methods for addressing publication
bias (e.g., sensitivity analyses for negative studies or gray literature) further strengthen the
conclusions?
assistant