Title: Prognostic Implications of CK19 Positivity in Patients with Early
Recurrent Hepatocellular Carcinoma after Hepatic Resection Undergoing Transarterial
Chemoembolization
Version: 1 Date: 30 Mar 2024
Reviewer:  Tsuyoshi Kobayashi
Reviewer's report:
1) There have been many previous reports of CK19 being a poor prognostic factor for HCC.
Although this analysis is limited to cases of early intrahepatic recurrence after HCC resection
and TACE, it is not surprising that CK19 positivity is a poor prognostic factor for HCC.
2) TACE unsuitability should be discussed.
3) DPHCC is not a generally accepted concept and seems abrupt. It is not logical that it is used
in the subgroup analysis of this study and that it is a negative result.
Title: Prognostic Implications of CK19 Positivity in Patients with Early
Recurrent Hepatocellular Carcinoma after Hepatic Resection Undergoing Transarterial
Chemoembolization
Version: 1 Date: 30 Mar 2024
Reviewer:  Tsuyoshi Kobayashi
Reviewer's report:
1) There have been many previous reports of CK19 being a poor prognostic factor for HCC.
Although this analysis is limited to cases of early intrahepatic recurrence after HCC resection
and TACE, it is not surprising that CK19 positivity is a poor prognostic factor for HCC.
2) TACE unsuitability should be discussed.
3) DPHCC is not a generally accepted concept and seems abrupt. It is not logical that it is used
in the subgroup analysis of this study and that it is a negative result.
Please review this paper.
user
Title: Prognostic Implications of CK19 Positivity in Patients with Early
Recurrent Hepatocellular Carcinoma after Hepatic Resection Undergoing Transarterial
Chemoembolization
Version: 1 Date: 30 Mar 2024
Reviewer:  Tsuyoshi Kobayashi
Reviewer's report:
1) There have been many previous reports of CK19 being a poor prognostic factor for HCC.
Although this analysis is limited to cases of early intrahepatic recurrence after HCC resection
and TACE, it is not surprising that CK19 positivity is a poor prognostic factor for HCC.
2) TACE unsuitability should be discussed.
3) DPHCC is not a generally accepted concept and seems abrupt. It is not logical that it is used
in the subgroup analysis of this study and that it is a negative result.
assistant