Title: Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote
esophageal squamous cell carcinoma migration and invasion
Version: 2 Date: 15 Mar 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
Re: "Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote
esophageal squamous cell carcinoma progression"
I would like to commend the authors on their study exploring the role of hypoxia-induced
exosomal circNRIP1 in the activation of cancer-associated fibroblasts (CAFs) and its impact
on esophageal squamous cell carcinoma (ESCC) progression. This study provides valuable
mechanistic insights into tumor-stroma interactions and highlights a potential therapeutic target
for ESCC. The integration of in vitro experiments, molecular analyses, and bioinformatics
predictions adds depth to the findings.
the study is well-structured and methodologically sound, and i find no comments to state
Sincerely,
Title: Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote
esophageal squamous cell carcinoma migration and invasion
Version: 2 Date: 15 Mar 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
Re: "Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote
esophageal squamous cell carcinoma progression"
I would like to commend the authors on their study exploring the role of hypoxia-induced
exosomal circNRIP1 in the activation of cancer-associated fibroblasts (CAFs) and its impact
on esophageal squamous cell carcinoma (ESCC) progression. This study provides valuable
mechanistic insights into tumor-stroma interactions and highlights a potential therapeutic target
for ESCC. The integration of in vitro experiments, molecular analyses, and bioinformatics
predictions adds depth to the findings.
the study is well-structured and methodologically sound, and i find no comments to state
Sincerely,
Please review this paper.
user
Title: Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote
esophageal squamous cell carcinoma migration and invasion
Version: 2 Date: 15 Mar 2025
Reviewer:  Mohamed H. Zidan
Reviewer's report:
Dear Authors,
Re: "Hypoxia-induced exosomal circNRIP1 activates cancer-associated fibroblasts to promote
esophageal squamous cell carcinoma progression"
I would like to commend the authors on their study exploring the role of hypoxia-induced
exosomal circNRIP1 in the activation of cancer-associated fibroblasts (CAFs) and its impact
on esophageal squamous cell carcinoma (ESCC) progression. This study provides valuable
mechanistic insights into tumor-stroma interactions and highlights a potential therapeutic target
for ESCC. The integration of in vitro experiments, molecular analyses, and bioinformatics
predictions adds depth to the findings.
the study is well-structured and methodologically sound, and i find no comments to state
Sincerely,
assistant