Title: Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal
cancer: a retrospective multicenter study
Version: 3 Date: 16 May 2023
Reviewer:  Tadahiko Masaki
Reviewer's report:
This study compared genetic alterations between sporadic and synchronous CRC, and attempted
to clarify its oncological implication. The authors succeeded on this point to some extent,
however, there are still some problems as shown below.
1. Results: The authors should describe the actual data of genetic mutations stratified by tumor
location using adquate Tables.
2. The authors claimed in Discussion section that the association between genetic mutations and
the prognosis of synchronous CRC patients remains unclear and is open to debate. Yes, that's
true.  In Dicussion section , they should discuss on this point in more details instead of citing lots
of previous publications. This reviewer believes that this discussion will improve the scientific
value of this paper.
Title: Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal
cancer: a retrospective multicenter study
Version: 3 Date: 16 May 2023
Reviewer:  Tadahiko Masaki
Reviewer's report:
This study compared genetic alterations between sporadic and synchronous CRC, and attempted
to clarify its oncological implication. The authors succeeded on this point to some extent,
however, there are still some problems as shown below.
1. Results: The authors should describe the actual data of genetic mutations stratified by tumor
location using adquate Tables.
2. The authors claimed in Discussion section that the association between genetic mutations and
the prognosis of synchronous CRC patients remains unclear and is open to debate. Yes, that's
true.  In Dicussion section , they should discuss on this point in more details instead of citing lots
of previous publications. This reviewer believes that this discussion will improve the scientific
value of this paper.
Please review this paper.
user
Title: Oncologic relevance of genetic alterations in sporadic synchronous and solitary colorectal
cancer: a retrospective multicenter study
Version: 3 Date: 16 May 2023
Reviewer:  Tadahiko Masaki
Reviewer's report:
This study compared genetic alterations between sporadic and synchronous CRC, and attempted
to clarify its oncological implication. The authors succeeded on this point to some extent,
however, there are still some problems as shown below.
1. Results: The authors should describe the actual data of genetic mutations stratified by tumor
location using adquate Tables.
2. The authors claimed in Discussion section that the association between genetic mutations and
the prognosis of synchronous CRC patients remains unclear and is open to debate. Yes, that's
true.  In Dicussion section , they should discuss on this point in more details instead of citing lots
of previous publications. This reviewer believes that this discussion will improve the scientific
value of this paper.
assistant