Reviewer's report
Title:An adjuvant free mouse model of oral allergenic sensitization to rice seeds
protein
Version: 2Date:14 March 2011
Reviewer: Eva Untersmayr
Reviewer's report:
Review of revised Ms. Nr. 1531535814417669 by Xiao-Wei Chen et al.
The authors have revised their manuscript according to the reviewers’
suggestions. Unfortunately, several important questions have remained
unanswered.
Major compulsory revision:
1. 1. As the authors decided to not include additional immunization experiments
to discriminate whether rice flour feeding or extracted rice flour protein
challenges are responsible for the observed sensitization, it would be of
importance to disclose these limitations in the discussion section.
2. Not only in the table but also in the figures mean +/- SD should be given as the
standard error of the mean (SEM) is the standard deviation of the error in the
sample mean relative to the true mean and thus does not provide enough
statistical information.
3. The manuscript still needs revision regarding English language and typing
errors.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:An adjuvant free mouse model of oral allergenic sensitization to rice seeds
protein
Version: 2Date:14 March 2011
Reviewer: Eva Untersmayr
Reviewer's report:
Review of revised Ms. Nr. 1531535814417669 by Xiao-Wei Chen et al.
The authors have revised their manuscript according to the reviewers’
suggestions. Unfortunately, several important questions have remained
unanswered.
Major compulsory revision:
1. 1. As the authors decided to not include additional immunization experiments
to discriminate whether rice flour feeding or extracted rice flour protein
challenges are responsible for the observed sensitization, it would be of
importance to disclose these limitations in the discussion section.
2. Not only in the table but also in the figures mean +/- SD should be given as the
standard error of the mean (SEM) is the standard deviation of the error in the
sample mean relative to the true mean and thus does not provide enough
statistical information.
3. The manuscript still needs revision regarding English language and typing
errors.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:An adjuvant free mouse model of oral allergenic sensitization to rice seeds
protein
Version: 2Date:14 March 2011
Reviewer: Eva Untersmayr
Reviewer's report:
Review of revised Ms. Nr. 1531535814417669 by Xiao-Wei Chen et al.
The authors have revised their manuscript according to the reviewers’
suggestions. Unfortunately, several important questions have remained
unanswered.
Major compulsory revision:
1. 1. As the authors decided to not include additional immunization experiments
to discriminate whether rice flour feeding or extracted rice flour protein
challenges are responsible for the observed sensitization, it would be of
importance to disclose these limitations in the discussion section.
2. Not only in the table but also in the figures mean +/- SD should be given as the
standard error of the mean (SEM) is the standard deviation of the error in the
sample mean relative to the true mean and thus does not provide enough
statistical information.
3. The manuscript still needs revision regarding English language and typing
errors.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
assistant