Reviewer's report
Title:Fibroblast growth factor 23 contributes to diminished bone mineral density
in childhood inflammatory bowel disease
Version: 1Date:13 March 2012
Reviewer: Franco Scaldaferri
Reviewer's report:
Well written, interesting paper, clear and simple descriptive aim. Methods are
well detailed, and data consistent with previous reports.
The introduction session is probably to brief, at least few more information about
the exact role of FGF23 and PHEX should be better clarified, so that the
hypothesis would sound more interesting and intriguing.
Few points need to be better addressed:
1 - which therapy enrolled patients were following before and after the flare;
2 - time for the second evaluation after reaching the remission (weeks,
months??)
3 - into the discussion session it should be stated issues related to bone density
and time related to normalization/reduction
4 - clarify, in case of vit D deficiency whether a therapeutical intervention was
provided and if not (as it appears reading this article), why and how this can be
justified
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:Fibroblast growth factor 23 contributes to diminished bone mineral density
in childhood inflammatory bowel disease
Version: 1Date:13 March 2012
Reviewer: Franco Scaldaferri
Reviewer's report:
Well written, interesting paper, clear and simple descriptive aim. Methods are
well detailed, and data consistent with previous reports.
The introduction session is probably to brief, at least few more information about
the exact role of FGF23 and PHEX should be better clarified, so that the
hypothesis would sound more interesting and intriguing.
Few points need to be better addressed:
1 - which therapy enrolled patients were following before and after the flare;
2 - time for the second evaluation after reaching the remission (weeks,
months??)
3 - into the discussion session it should be stated issues related to bone density
and time related to normalization/reduction
4 - clarify, in case of vit D deficiency whether a therapeutical intervention was
provided and if not (as it appears reading this article), why and how this can be
justified
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:Fibroblast growth factor 23 contributes to diminished bone mineral density
in childhood inflammatory bowel disease
Version: 1Date:13 March 2012
Reviewer: Franco Scaldaferri
Reviewer's report:
Well written, interesting paper, clear and simple descriptive aim. Methods are
well detailed, and data consistent with previous reports.
The introduction session is probably to brief, at least few more information about
the exact role of FGF23 and PHEX should be better clarified, so that the
hypothesis would sound more interesting and intriguing.
Few points need to be better addressed:
1 - which therapy enrolled patients were following before and after the flare;
2 - time for the second evaluation after reaching the remission (weeks,
months??)
3 - into the discussion session it should be stated issues related to bone density
and time related to normalization/reduction
4 - clarify, in case of vit D deficiency whether a therapeutical intervention was
provided and if not (as it appears reading this article), why and how this can be
justified
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant