Title: The causal relationship between inflammatory bowel diseases and erythema nodosum: a
bidirectional two-sample Mendelian randomization study
Version: 1 Date: 25 Jun 2024
Reviewer's report:
This is a well-structured and statistically robust investigation into the bidirectional relationship
between IBD and EN using Mendelian randomization. Despite a few limitations due to the study
design, I believe the study effectively addresses an interesting topic. The following are some
of my comments:
1. Is it possible to perform subgroup analysis given that IBD is a heterogeneous disease? I wonder
how the age of onset (early-onset IBD, elderly-onset IBD, VEO-IBD, etc.) and disease extent
(especially in CD - ileocolonic, colonic, small bowel, UGI) would affect the outcomes.
2. As noted, there could be variations across different ethnic backgrounds, necessitating careful
interpretation.
3. Additionally, due to the study design, there are inherent limitations, such as the inability to
consider various clinical factors, including disease activity, medication use, and endoscopic/
radiologic findings.
Title: The causal relationship between inflammatory bowel diseases and erythema nodosum: a
bidirectional two-sample Mendelian randomization study
Version: 1 Date: 25 Jun 2024
Reviewer's report:
This is a well-structured and statistically robust investigation into the bidirectional relationship
between IBD and EN using Mendelian randomization. Despite a few limitations due to the study
design, I believe the study effectively addresses an interesting topic. The following are some
of my comments:
1. Is it possible to perform subgroup analysis given that IBD is a heterogeneous disease? I wonder
how the age of onset (early-onset IBD, elderly-onset IBD, VEO-IBD, etc.) and disease extent
(especially in CD - ileocolonic, colonic, small bowel, UGI) would affect the outcomes.
2. As noted, there could be variations across different ethnic backgrounds, necessitating careful
interpretation.
3. Additionally, due to the study design, there are inherent limitations, such as the inability to
consider various clinical factors, including disease activity, medication use, and endoscopic/
radiologic findings.
Please review this paper.
user
Title: The causal relationship between inflammatory bowel diseases and erythema nodosum: a
bidirectional two-sample Mendelian randomization study
Version: 1 Date: 25 Jun 2024
Reviewer's report:
This is a well-structured and statistically robust investigation into the bidirectional relationship
between IBD and EN using Mendelian randomization. Despite a few limitations due to the study
design, I believe the study effectively addresses an interesting topic. The following are some
of my comments:
1. Is it possible to perform subgroup analysis given that IBD is a heterogeneous disease? I wonder
how the age of onset (early-onset IBD, elderly-onset IBD, VEO-IBD, etc.) and disease extent
(especially in CD - ileocolonic, colonic, small bowel, UGI) would affect the outcomes.
2. As noted, there could be variations across different ethnic backgrounds, necessitating careful
interpretation.
3. Additionally, due to the study design, there are inherent limitations, such as the inability to
consider various clinical factors, including disease activity, medication use, and endoscopic/
radiologic findings.
assistant