Reviewer's report
Title:Safety and efficacy of the immunosuppressive agent 6-tioguanine in
murine model of acute and chronic colitis
Version: 3Date:22 March 2011
Reviewer: Yuji Naito
Reviewer's report:
The authors revised it according the suggestion of us. However,in the mouse
model, they could not detect the serum levels of 6TGN, indicating the there may
be a big differences between human and mice. In addition,previous data clearly
indicate that the adverse effect of AZT and 6-tioguanine, in part, is derived from
the genetic differences of metabolic enzymes. In my opinion, this paper's
contribution for the safety/efficacy of this drug is small.
However, I agree with your final decision completely.
Reviewer's report
Title:Safety and efficacy of the immunosuppressive agent 6-tioguanine in
murine model of acute and chronic colitis
Version: 3Date:22 March 2011
Reviewer: Yuji Naito
Reviewer's report:
The authors revised it according the suggestion of us. However,in the mouse
model, they could not detect the serum levels of 6TGN, indicating the there may
be a big differences between human and mice. In addition,previous data clearly
indicate that the adverse effect of AZT and 6-tioguanine, in part, is derived from
the genetic differences of metabolic enzymes. In my opinion, this paper's
contribution for the safety/efficacy of this drug is small.
However, I agree with your final decision completely.
Please review this paper.
user
Reviewer's report
Title:Safety and efficacy of the immunosuppressive agent 6-tioguanine in
murine model of acute and chronic colitis
Version: 3Date:22 March 2011
Reviewer: Yuji Naito
Reviewer's report:
The authors revised it according the suggestion of us. However,in the mouse
model, they could not detect the serum levels of 6TGN, indicating the there may
be a big differences between human and mice. In addition,previous data clearly
indicate that the adverse effect of AZT and 6-tioguanine, in part, is derived from
the genetic differences of metabolic enzymes. In my opinion, this paper's
contribution for the safety/efficacy of this drug is small.
However, I agree with your final decision completely.
assistant