Reviewer's report
Title:Rifaximin for maintenance therapy in antibiotic-dependent pouchitis
Version: 1Date:26 December 2007
Reviewer: Ayman S Abdelrazeq
Reviewer's report:
Thank you for the opportunity to re-review this manuscript. The manuscript is of
interest I have listed few comments
Major Compulsory Revisions
1-It will be very useful to present your pouchitis management algorithm.
2- When would you use a single vs. combination therapy to induce remission?
Minor Essential Revisions
1- A reference is required to support your statement that many patients
experience only one acute episode of pouchitis.
2- Your group has reported that the use of NSAID is an independent risk factor
for chronic pouchitis. Yet you have asked your patients who are on regular
NSAIDs to stop using these drugs for the duration of study ONLY, please clarify.
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Rifaximin for maintenance therapy in antibiotic-dependent pouchitis
Version: 1Date:26 December 2007
Reviewer: Ayman S Abdelrazeq
Reviewer's report:
Thank you for the opportunity to re-review this manuscript. The manuscript is of
interest I have listed few comments
Major Compulsory Revisions
1-It will be very useful to present your pouchitis management algorithm.
2- When would you use a single vs. combination therapy to induce remission?
Minor Essential Revisions
1- A reference is required to support your statement that many patients
experience only one acute episode of pouchitis.
2- Your group has reported that the use of NSAID is an independent risk factor
for chronic pouchitis. Yet you have asked your patients who are on regular
NSAIDs to stop using these drugs for the duration of study ONLY, please clarify.
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Rifaximin for maintenance therapy in antibiotic-dependent pouchitis
Version: 1Date:26 December 2007
Reviewer: Ayman S Abdelrazeq
Reviewer's report:
Thank you for the opportunity to re-review this manuscript. The manuscript is of
interest I have listed few comments
Major Compulsory Revisions
1-It will be very useful to present your pouchitis management algorithm.
2- When would you use a single vs. combination therapy to induce remission?
Minor Essential Revisions
1- A reference is required to support your statement that many patients
experience only one acute episode of pouchitis.
2- Your group has reported that the use of NSAID is an independent risk factor
for chronic pouchitis. Yet you have asked your patients who are on regular
NSAIDs to stop using these drugs for the duration of study ONLY, please clarify.
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
assistant