Reviewer's report
Title:Marginal turbid band and light blue crest, signs observed in magnifying
narrow-band imaging endoscopy, are indicative of gastric intestinal metaplasia
Version: 1Date:1 July 2012
Reviewer: Tiing Leong Ang
Reviewer's report:
This study examined the use of NBI magnifying endoscopy for diagnosis of IM.
Major comments
1. Methods (study population): why were patients on h2 antagonists or PPI
excluded? Why were patients with treated H pylori i9nfection treated?
2. Methods (endoscopic procedures): The MTB appears similar to LBC from the
image. It is not convincigly shown that this is a novel finding, and ot part of
spectrum of LBC.
3. Methods (endoscopic procedures): How many biopsies were taken at each
site? Was this standardized?
4. Results: Why were only 93 areas (not 94) evaluated? number of patietns was
47 and the plan was to evalaute the lesser and greater curve.
5.Results and discssion: are the endoscopic features (LBC/ MTB) evalauting IM
and atrophy? Or are they evaluating IM, and the detection of any atrophy a
reflection of the severity of the gastric mucosal inflmmation and change?
Minor comments
1. NBI is current ly no longer considered a noew or novel technology as it has
been in clincial use for many years. Hence the terms "new" and "newly
developed" should be deleted in the text.
2. There are some grammatical and typographical erros tat should be corrected.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Marginal turbid band and light blue crest, signs observed in magnifying
narrow-band imaging endoscopy, are indicative of gastric intestinal metaplasia
Version: 1Date:1 July 2012
Reviewer: Tiing Leong Ang
Reviewer's report:
This study examined the use of NBI magnifying endoscopy for diagnosis of IM.
Major comments
1. Methods (study population): why were patients on h2 antagonists or PPI
excluded? Why were patients with treated H pylori i9nfection treated?
2. Methods (endoscopic procedures): The MTB appears similar to LBC from the
image. It is not convincigly shown that this is a novel finding, and ot part of
spectrum of LBC.
3. Methods (endoscopic procedures): How many biopsies were taken at each
site? Was this standardized?
4. Results: Why were only 93 areas (not 94) evaluated? number of patietns was
47 and the plan was to evalaute the lesser and greater curve.
5.Results and discssion: are the endoscopic features (LBC/ MTB) evalauting IM
and atrophy? Or are they evaluating IM, and the detection of any atrophy a
reflection of the severity of the gastric mucosal inflmmation and change?
Minor comments
1. NBI is current ly no longer considered a noew or novel technology as it has
been in clincial use for many years. Hence the terms "new" and "newly
developed" should be deleted in the text.
2. There are some grammatical and typographical erros tat should be corrected.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Marginal turbid band and light blue crest, signs observed in magnifying
narrow-band imaging endoscopy, are indicative of gastric intestinal metaplasia
Version: 1Date:1 July 2012
Reviewer: Tiing Leong Ang
Reviewer's report:
This study examined the use of NBI magnifying endoscopy for diagnosis of IM.
Major comments
1. Methods (study population): why were patients on h2 antagonists or PPI
excluded? Why were patients with treated H pylori i9nfection treated?
2. Methods (endoscopic procedures): The MTB appears similar to LBC from the
image. It is not convincigly shown that this is a novel finding, and ot part of
spectrum of LBC.
3. Methods (endoscopic procedures): How many biopsies were taken at each
site? Was this standardized?
4. Results: Why were only 93 areas (not 94) evaluated? number of patietns was
47 and the plan was to evalaute the lesser and greater curve.
5.Results and discssion: are the endoscopic features (LBC/ MTB) evalauting IM
and atrophy? Or are they evaluating IM, and the detection of any atrophy a
reflection of the severity of the gastric mucosal inflmmation and change?
Minor comments
1. NBI is current ly no longer considered a noew or novel technology as it has
been in clincial use for many years. Hence the terms "new" and "newly
developed" should be deleted in the text.
2. There are some grammatical and typographical erros tat should be corrected.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant