Reviewer’s report
Title: 
Mixed adenoneuroendocrine carcinoma of the hepatic bile duct:a case
report and review of the literature
Version: 
0 
Date: 
09 Feb 2020
Reviewer: 
Stefano Rausei
Reviewer's report:
The case presented by Zhong et al is rare and interesting. However, the
manuscript could be improved.
1) In different parts Authors show too many details, for example in "case
history" too many unhelpful laboratory exams as well as in "discussion" too
many weel-known classifications!
2) The reliability of CT scan is not so clear if compared with surgical report:
particularly, which surgical finding did Authors describe about suspected
invasion of portal hepatic hilum area and retroperitoneal nodes?
3) How Authors did perform follow-up of patient? CT? MR? Which f-up
schedule?
4) A picture of the specimen or the surgical field could improve the manuscript.
5) In the Discussion Authors should better clarify the link between "the early
onset" and "the poor prognosis" of this tumor.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name
will be included on my report to the authors and, if the manuscript is accepted
for publication, my named report including any attachments I upload will be
posted on the website along with the authors' responses. I agree for my report to
be made available under an Open Access Creative Commons CC-BY license
(
http://creativecommons.org/licenses/by/4.0/
). I understand that any comments
which I do not wish to be included in my named report can be included as
confidential comments to the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’s report
Title: 
Mixed adenoneuroendocrine carcinoma of the hepatic bile duct:a case
report and review of the literature
Version: 
0 
Date: 
09 Feb 2020
Reviewer: 
Stefano Rausei
Reviewer's report:
The case presented by Zhong et al is rare and interesting. However, the
manuscript could be improved.
1) In different parts Authors show too many details, for example in "case
history" too many unhelpful laboratory exams as well as in "discussion" too
many weel-known classifications!
2) The reliability of CT scan is not so clear if compared with surgical report:
particularly, which surgical finding did Authors describe about suspected
invasion of portal hepatic hilum area and retroperitoneal nodes?
3) How Authors did perform follow-up of patient? CT? MR? Which f-up
schedule?
4) A picture of the specimen or the surgical field could improve the manuscript.
5) In the Discussion Authors should better clarify the link between "the early
onset" and "the poor prognosis" of this tumor.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name
will be included on my report to the authors and, if the manuscript is accepted
for publication, my named report including any attachments I upload will be
posted on the website along with the authors' responses. I agree for my report to
be made available under an Open Access Creative Commons CC-BY license
(
http://creativecommons.org/licenses/by/4.0/
). I understand that any comments
which I do not wish to be included in my named report can be included as
confidential comments to the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’s report
Title: 
Mixed adenoneuroendocrine carcinoma of the hepatic bile duct:a case
report and review of the literature
Version: 
0 
Date: 
09 Feb 2020
Reviewer: 
Stefano Rausei
Reviewer's report:
The case presented by Zhong et al is rare and interesting. However, the
manuscript could be improved.
1) In different parts Authors show too many details, for example in "case
history" too many unhelpful laboratory exams as well as in "discussion" too
many weel-known classifications!
2) The reliability of CT scan is not so clear if compared with surgical report:
particularly, which surgical finding did Authors describe about suspected
invasion of portal hepatic hilum area and retroperitoneal nodes?
3) How Authors did perform follow-up of patient? CT? MR? Which f-up
schedule?
4) A picture of the specimen or the surgical field could improve the manuscript.
5) In the Discussion Authors should better clarify the link between "the early
onset" and "the poor prognosis" of this tumor.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the
authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you
recommend an additional statistical review?
If an additional statistical review is recommended, please specify what aspects
require further assessment in your comments to the editors.
Not relevant to this manuscript
Quality of written English
Please indicate the quality of language in the manuscript:
Needs some language corrections before being published
Declaration of competing interests
Please complete a declaration of competing interests, considering the following
questions:
1
. 
Have you in the past five years received reimbursements, fees, funding, or
salary from an organisation that may in any way gain or lose financially
from the publication of this manuscript, either now or in the future?
2
. 
Do you hold any stocks or shares in an organisation that may in any way
gain or lose financially from the publication of this manuscript, either now
or in the future?
3
. 
Do you hold or are you currently applying for any patents relating to the
content of the manuscript?
4
. 
Have you received reimbursements, fees, funding, or salary from an
organization that holds or has applied for patents relating to the content of
the manuscript?
5
. 
Do you have any other financial competing interests?
6
. 
Do you have any non-financial competing interests in relation to this
paper?
If you can answer no to all of the above, write 'I declare that I have no competing
interests' below. If your reply is yes to any, please give details below.
I have no competing interests
I agree to the open peer review policy of the journal. I understand that my name
will be included on my report to the authors and, if the manuscript is accepted
for publication, my named report including any attachments I upload will be
posted on the website along with the authors' responses. I agree for my report to
be made available under an Open Access Creative Commons CC-BY license
(
http://creativecommons.org/licenses/by/4.0/
). I understand that any comments
which I do not wish to be included in my named report can be included as
confidential comments to the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant