Title: The effect of chewing gum on postoperative ileus after laparotomy for gastroduodenal
perforations: A randomized controlled trial.
Version: 2 Date: 17 Jun 2024
Reviewer's report:
This study evaluated the effect of chewing gum on the postoperative ileus which develop after
laparotomy for gastroduodenal perforations. The results demonstrated that chewing gum shorten
the duration of post-operative ileus and the length of hospital stay. Although the sample size is
relatively small, the outcome assessors were blinded about this trial, and these findings are likely
valid. On the other hand, since relatively more patients in chewing gum group had leakage and
burst abdomen, it is difficult to interpret the outcomes regarding the superiority of chewing gum.
Major points
1.The resolution of postoperative ileus and the timing of discharge is also affected by the degree
of inflammation including peritonitis and SIRS as well as postoperative complications, but the
findings of inflammation during or after surgery is not evaluated. Furthermore, according to the
protocol, postoperative antibiotics are supposed to be administered for 5 days, but some patients
discharged before POD5.
2.This study did not evaluate the type of surgical procedure, which can affect the postoperative
course. In addition, resumption of oral take after surgery of gastroduodenal perforations may be
complicated compared to other surgeries, which should be described.
Title: The effect of chewing gum on postoperative ileus after laparotomy for gastroduodenal
perforations: A randomized controlled trial.
Version: 2 Date: 17 Jun 2024
Reviewer's report:
This study evaluated the effect of chewing gum on the postoperative ileus which develop after
laparotomy for gastroduodenal perforations. The results demonstrated that chewing gum shorten
the duration of post-operative ileus and the length of hospital stay. Although the sample size is
relatively small, the outcome assessors were blinded about this trial, and these findings are likely
valid. On the other hand, since relatively more patients in chewing gum group had leakage and
burst abdomen, it is difficult to interpret the outcomes regarding the superiority of chewing gum.
Major points
1.The resolution of postoperative ileus and the timing of discharge is also affected by the degree
of inflammation including peritonitis and SIRS as well as postoperative complications, but the
findings of inflammation during or after surgery is not evaluated. Furthermore, according to the
protocol, postoperative antibiotics are supposed to be administered for 5 days, but some patients
discharged before POD5.
2.This study did not evaluate the type of surgical procedure, which can affect the postoperative
course. In addition, resumption of oral take after surgery of gastroduodenal perforations may be
complicated compared to other surgeries, which should be described.
Please review this paper.
user
Title: The effect of chewing gum on postoperative ileus after laparotomy for gastroduodenal
perforations: A randomized controlled trial.
Version: 2 Date: 17 Jun 2024
Reviewer's report:
This study evaluated the effect of chewing gum on the postoperative ileus which develop after
laparotomy for gastroduodenal perforations. The results demonstrated that chewing gum shorten
the duration of post-operative ileus and the length of hospital stay. Although the sample size is
relatively small, the outcome assessors were blinded about this trial, and these findings are likely
valid. On the other hand, since relatively more patients in chewing gum group had leakage and
burst abdomen, it is difficult to interpret the outcomes regarding the superiority of chewing gum.
Major points
1.The resolution of postoperative ileus and the timing of discharge is also affected by the degree
of inflammation including peritonitis and SIRS as well as postoperative complications, but the
findings of inflammation during or after surgery is not evaluated. Furthermore, according to the
protocol, postoperative antibiotics are supposed to be administered for 5 days, but some patients
discharged before POD5.
2.This study did not evaluate the type of surgical procedure, which can affect the postoperative
course. In addition, resumption of oral take after surgery of gastroduodenal perforations may be
complicated compared to other surgeries, which should be described.
assistant