Title: Relationship between HER2 overexpression and long-term outcomes of early gastric
cancer: A prospective observational study with a 6-year follow-up
Version: 1 Date: 06 Mar 2022
Reviewer:  Akio Kaito
Reviewer's report:
Dear authors,
Thank you very much for giving me such a great opportunity of reviewing valuable manuscripts.
Your current study seemed well written and worth publishing on this journal, because prognostic
significance of HER2 status in early gastric cancer had not been clarified  yet. The recurrence
rate for HER2 positive EGC in the current study was surprisingly high compared to those of
HER2 negative and other recurrence rate in the multicenter study  such as JCOG0607 (Hasuike,
et al. Gastric cancer, 2017).
Major comments:
1. The recurrence pattern would be stated on your manuscript. Does recurrence included not only
metastatic extra-gastric lesion but metachronous  gastric cancer? If so, these two lesions should
be classified. Recurrence rate for HER2 positive EGC in this study was very high compared
to those of previous reports, granted metachronous lesions were not included as recurrence in
the current study.
Title: Relationship between HER2 overexpression and long-term outcomes of early gastric
cancer: A prospective observational study with a 6-year follow-up
Version: 1 Date: 06 Mar 2022
Reviewer:  Akio Kaito
Reviewer's report:
Dear authors,
Thank you very much for giving me such a great opportunity of reviewing valuable manuscripts.
Your current study seemed well written and worth publishing on this journal, because prognostic
significance of HER2 status in early gastric cancer had not been clarified  yet. The recurrence
rate for HER2 positive EGC in the current study was surprisingly high compared to those of
HER2 negative and other recurrence rate in the multicenter study  such as JCOG0607 (Hasuike,
et al. Gastric cancer, 2017).
Major comments:
1. The recurrence pattern would be stated on your manuscript. Does recurrence included not only
metastatic extra-gastric lesion but metachronous  gastric cancer? If so, these two lesions should
be classified. Recurrence rate for HER2 positive EGC in this study was very high compared
to those of previous reports, granted metachronous lesions were not included as recurrence in
the current study.
Please review this paper.
user
Title: Relationship between HER2 overexpression and long-term outcomes of early gastric
cancer: A prospective observational study with a 6-year follow-up
Version: 1 Date: 06 Mar 2022
Reviewer:  Akio Kaito
Reviewer's report:
Dear authors,
Thank you very much for giving me such a great opportunity of reviewing valuable manuscripts.
Your current study seemed well written and worth publishing on this journal, because prognostic
significance of HER2 status in early gastric cancer had not been clarified  yet. The recurrence
rate for HER2 positive EGC in the current study was surprisingly high compared to those of
HER2 negative and other recurrence rate in the multicenter study  such as JCOG0607 (Hasuike,
et al. Gastric cancer, 2017).
Major comments:
1. The recurrence pattern would be stated on your manuscript. Does recurrence included not only
metastatic extra-gastric lesion but metachronous  gastric cancer? If so, these two lesions should
be classified. Recurrence rate for HER2 positive EGC in this study was very high compared
to those of previous reports, granted metachronous lesions were not included as recurrence in
the current study.
assistant