Reviewer ’s report  
 
Title: Significantly different clinical features between hypertriglyceridemia and biliary acute 
pancreatitis: A Retrospective Study of 730 Patients from A Tertiary  
 
Version: 1 Date: 25 Dec 2017  
 
Reviewer: Eisuke Iwasaki  
 
Reviewer's report:  
 
I am honored to review your revision manuscript.  
Authors showed that HTG -AP patients suffered more severe systemic inflammation reaction, 
while BAP patients had a greater severity of infected complications. Authors should concern 
below points.  
I think that your conclusions do not appear to be suitable from the results of this report. HTG 
was found to be independently associated with only AKI, but not ARDS and DVT, while body 
mass index (BMI) was associated with all three complications in multivariate analysis. The 
results of multivariate analysis should be emphasized rather than the result s of univariate 
analysis. The author should describe that high BMI was more severe disease course in spite of 
etiology in conclusion.  
In the first section of the discussion, the author should describe that HTG was found to be 
independently associated wit h only AKI, but not ARDS and DVT, while body mass index (BMI) 
was associated with all three complications in multivariate analysis. The author also should 
describe the result of multivariate analysis rather than that of univariate analysis in abstract.   
Moreover, the incidence of systemic complication did not increased with the higher TG level by 
Cochran Armitage trend test. Even if there was limitation like the peak TG level within 72 h of 
hospital admission with AP, this result also did not support that  HTG AP patients suffered 
clinically more severe disease course, higher disease burden than patients with BAP.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
  
Are the conclusions drawn adequately supported  by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an ad ditional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscri pt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either no w or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to  the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing inte rests' 
below.  If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the m anuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Significantly different clinical features between hypertriglyceridemia and biliary acute 
pancreatitis: A Retrospective Study of 730 Patients from A Tertiary  
 
Version: 1 Date: 25 Dec 2017  
 
Reviewer: Eisuke Iwasaki  
 
Reviewer's report:  
 
I am honored to review your revision manuscript.  
Authors showed that HTG -AP patients suffered more severe systemic inflammation reaction, 
while BAP patients had a greater severity of infected complications. Authors should concern 
below points.  
I think that your conclusions do not appear to be suitable from the results of this report. HTG 
was found to be independently associated with only AKI, but not ARDS and DVT, while body 
mass index (BMI) was associated with all three complications in multivariate analysis. The 
results of multivariate analysis should be emphasized rather than the result s of univariate 
analysis. The author should describe that high BMI was more severe disease course in spite of 
etiology in conclusion.  
In the first section of the discussion, the author should describe that HTG was found to be 
independently associated wit h only AKI, but not ARDS and DVT, while body mass index (BMI) 
was associated with all three complications in multivariate analysis. The author also should 
describe the result of multivariate analysis rather than that of univariate analysis in abstract.   
Moreover, the incidence of systemic complication did not increased with the higher TG level by 
Cochran Armitage trend test. Even if there was limitation like the peak TG level within 72 h of 
hospital admission with AP, this result also did not support that  HTG AP patients suffered 
clinically more severe disease course, higher disease burden than patients with BAP.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
  
Are the conclusions drawn adequately supported  by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an ad ditional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscri pt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either no w or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to  the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing inte rests' 
below.  If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the m anuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Significantly different clinical features between hypertriglyceridemia and biliary acute 
pancreatitis: A Retrospective Study of 730 Patients from A Tertiary  
 
Version: 1 Date: 25 Dec 2017  
 
Reviewer: Eisuke Iwasaki  
 
Reviewer's report:  
 
I am honored to review your revision manuscript.  
Authors showed that HTG -AP patients suffered more severe systemic inflammation reaction, 
while BAP patients had a greater severity of infected complications. Authors should concern 
below points.  
I think that your conclusions do not appear to be suitable from the results of this report. HTG 
was found to be independently associated with only AKI, but not ARDS and DVT, while body 
mass index (BMI) was associated with all three complications in multivariate analysis. The 
results of multivariate analysis should be emphasized rather than the result s of univariate 
analysis. The author should describe that high BMI was more severe disease course in spite of 
etiology in conclusion.  
In the first section of the discussion, the author should describe that HTG was found to be 
independently associated wit h only AKI, but not ARDS and DVT, while body mass index (BMI) 
was associated with all three complications in multivariate analysis. The author also should 
describe the result of multivariate analysis rather than that of univariate analysis in abstract.   
Moreover, the incidence of systemic complication did not increased with the higher TG level by 
Cochran Armitage trend test. Even if there was limitation like the peak TG level within 72 h of 
hospital admission with AP, this result also did not support that  HTG AP patients suffered 
clinically more severe disease course, higher disease burden than patients with BAP.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
  
Are the conclusions drawn adequately supported  by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an ad ditional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I recommend additional statistical review  
 
Quality of written English  
Please indicate the quality of language in the manuscri pt: 
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either no w or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to  the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing inte rests' 
below.  If your reply is yes to any, please give details below.  
 
'I declare that I have no competing interests'  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the m anuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant