Title: Clinicopathological significance of HSP70 expression in gastric cancer: a systematic
review and meta-analysis
Version: 0 Date: 11 Aug 2021
Reviewer's report:
In this manuscript, Wang et al tried to show the clinicopathological meaning of HSP70 in GC
by meta-analysis. In general, the manuscript showed some work, the methods is fine. However,
the most recent included study for meta-analysis were published 5 years ago. Thus, it maybe
useless to publish such a meta-analysis. I suggest a review on the meaning of HSP70 in GC and
included most recent studies is more useful. My detailed comments is as followed:
1. The most recent included study for meta-analysis were published 5 years ago in 2016. Since
2016, many studies have also discussed the meaning of HSP70 in GC. Maybe unable to include
these studies in meta-analysis, the author could consider a review on this topic and provide more
information for readers.
2. The NOS score should be provided in detail by table.
3. The results “Association between HSP70 expression and TNM stage” should be provided in
detail. Are included studies used some criteria to define high and low TNM stage?
Title: Clinicopathological significance of HSP70 expression in gastric cancer: a systematic
review and meta-analysis
Version: 0 Date: 11 Aug 2021
Reviewer's report:
In this manuscript, Wang et al tried to show the clinicopathological meaning of HSP70 in GC
by meta-analysis. In general, the manuscript showed some work, the methods is fine. However,
the most recent included study for meta-analysis were published 5 years ago. Thus, it maybe
useless to publish such a meta-analysis. I suggest a review on the meaning of HSP70 in GC and
included most recent studies is more useful. My detailed comments is as followed:
1. The most recent included study for meta-analysis were published 5 years ago in 2016. Since
2016, many studies have also discussed the meaning of HSP70 in GC. Maybe unable to include
these studies in meta-analysis, the author could consider a review on this topic and provide more
information for readers.
2. The NOS score should be provided in detail by table.
3. The results “Association between HSP70 expression and TNM stage” should be provided in
detail. Are included studies used some criteria to define high and low TNM stage?
Please review this paper.
user
Title: Clinicopathological significance of HSP70 expression in gastric cancer: a systematic
review and meta-analysis
Version: 0 Date: 11 Aug 2021
Reviewer's report:
In this manuscript, Wang et al tried to show the clinicopathological meaning of HSP70 in GC
by meta-analysis. In general, the manuscript showed some work, the methods is fine. However,
the most recent included study for meta-analysis were published 5 years ago. Thus, it maybe
useless to publish such a meta-analysis. I suggest a review on the meaning of HSP70 in GC and
included most recent studies is more useful. My detailed comments is as followed:
1. The most recent included study for meta-analysis were published 5 years ago in 2016. Since
2016, many studies have also discussed the meaning of HSP70 in GC. Maybe unable to include
these studies in meta-analysis, the author could consider a review on this topic and provide more
information for readers.
2. The NOS score should be provided in detail by table.
3. The results “Association between HSP70 expression and TNM stage” should be provided in
detail. Are included studies used some criteria to define high and low TNM stage?
assistant