Reviewer's report
Title:The relationship between unrecognized gastroesophageal reflux disease
and excessive daytime sleepiness in Taiwan: A pilot study
Version: 2Date:13 January 2011
Reviewer: Yasuhiro Fujiwara
Reviewer's report:
Summary
The authors examined relationship between GERD and excessive daytime
sleepiness using two questionnaires including CESS and CGERDQ, and found
that about half of 73 patients with excessive daytime sleepiness without liver
diseases had GERD. This small clinical study has several problems in
methodology.
1- I could not understand why the primary care doctor suspected excessive
daytime sleepiness is related to liver disease. How many such patients visited at
the hospital? How many patients were excluded by exclusion criteria? Why the
authors excluded HBV and HCV carrier? Is there any evidence about positive
associations between daytime sleepiness and hepatitis virus carriers? In
addition, generally ESS is used for sleep apnea syndrome which might be
associated with GERD.
2- In results, the authors should show how many patients had positive ESS
(>10). It is no meaning that GERD patients showed higher score of CGERDQ
compared with non-GERD patients. Lack of control weakened the study power.
3- Although the study subjects had excessive daytime sleepiness, score of ESS
was low.
4- There are several grammatical errors in this manuscript.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:The relationship between unrecognized gastroesophageal reflux disease
and excessive daytime sleepiness in Taiwan: A pilot study
Version: 2Date:13 January 2011
Reviewer: Yasuhiro Fujiwara
Reviewer's report:
Summary
The authors examined relationship between GERD and excessive daytime
sleepiness using two questionnaires including CESS and CGERDQ, and found
that about half of 73 patients with excessive daytime sleepiness without liver
diseases had GERD. This small clinical study has several problems in
methodology.
1- I could not understand why the primary care doctor suspected excessive
daytime sleepiness is related to liver disease. How many such patients visited at
the hospital? How many patients were excluded by exclusion criteria? Why the
authors excluded HBV and HCV carrier? Is there any evidence about positive
associations between daytime sleepiness and hepatitis virus carriers? In
addition, generally ESS is used for sleep apnea syndrome which might be
associated with GERD.
2- In results, the authors should show how many patients had positive ESS
(>10). It is no meaning that GERD patients showed higher score of CGERDQ
compared with non-GERD patients. Lack of control weakened the study power.
3- Although the study subjects had excessive daytime sleepiness, score of ESS
was low.
4- There are several grammatical errors in this manuscript.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:The relationship between unrecognized gastroesophageal reflux disease
and excessive daytime sleepiness in Taiwan: A pilot study
Version: 2Date:13 January 2011
Reviewer: Yasuhiro Fujiwara
Reviewer's report:
Summary
The authors examined relationship between GERD and excessive daytime
sleepiness using two questionnaires including CESS and CGERDQ, and found
that about half of 73 patients with excessive daytime sleepiness without liver
diseases had GERD. This small clinical study has several problems in
methodology.
1- I could not understand why the primary care doctor suspected excessive
daytime sleepiness is related to liver disease. How many such patients visited at
the hospital? How many patients were excluded by exclusion criteria? Why the
authors excluded HBV and HCV carrier? Is there any evidence about positive
associations between daytime sleepiness and hepatitis virus carriers? In
addition, generally ESS is used for sleep apnea syndrome which might be
associated with GERD.
2- In results, the authors should show how many patients had positive ESS
(>10). It is no meaning that GERD patients showed higher score of CGERDQ
compared with non-GERD patients. Lack of control weakened the study power.
3- Although the study subjects had excessive daytime sleepiness, score of ESS
was low.
4- There are several grammatical errors in this manuscript.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
assistant