Reviewer's report
Title:Alpha-Fetoprotein Level as a Biomarker of Liver Fibrosis Status in 619
consecutive patients with Chronic Hepatitis B
Version:2Date:19 April 2014
Reviewer: Vincenza Calvaruso
Reviewer's report:
In this second version the authors improved the readability of the manuscript and
listed the several limitations of the manuscript in the discussion.
Even if the performance of AFP in predicting fibrosis among patients with chronic
hepatitis B remains contestable, the proposal to create a model using a
combination of different biomarkers could lead to interesting results.
In the previous version of the manuscript the median values of AFP at liver
inflammation stages null was 6.1 ng/ml which was higher than the values
reported for the severe stages of inflammation. However in the table 3 of this new
version the median value is 2.7 ng/ml. How the authors explain this difference?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
NA
Reviewer's report
Title:Alpha-Fetoprotein Level as a Biomarker of Liver Fibrosis Status in 619
consecutive patients with Chronic Hepatitis B
Version:2Date:19 April 2014
Reviewer: Vincenza Calvaruso
Reviewer's report:
In this second version the authors improved the readability of the manuscript and
listed the several limitations of the manuscript in the discussion.
Even if the performance of AFP in predicting fibrosis among patients with chronic
hepatitis B remains contestable, the proposal to create a model using a
combination of different biomarkers could lead to interesting results.
In the previous version of the manuscript the median values of AFP at liver
inflammation stages null was 6.1 ng/ml which was higher than the values
reported for the severe stages of inflammation. However in the table 3 of this new
version the median value is 2.7 ng/ml. How the authors explain this difference?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
NA
Please review this paper.
user
Reviewer's report
Title:Alpha-Fetoprotein Level as a Biomarker of Liver Fibrosis Status in 619
consecutive patients with Chronic Hepatitis B
Version:2Date:19 April 2014
Reviewer: Vincenza Calvaruso
Reviewer's report:
In this second version the authors improved the readability of the manuscript and
listed the several limitations of the manuscript in the discussion.
Even if the performance of AFP in predicting fibrosis among patients with chronic
hepatitis B remains contestable, the proposal to create a model using a
combination of different biomarkers could lead to interesting results.
In the previous version of the manuscript the median values of AFP at liver
inflammation stages null was 6.1 ng/ml which was higher than the values
reported for the severe stages of inflammation. However in the table 3 of this new
version the median value is 2.7 ng/ml. How the authors explain this difference?
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
NA
assistant