Title: Predictors of the experience of a Cytosponge test: analysis of patient survey data from
the BEST3 trial
Version: 2 Date: 15 Sep 2022
Reviewer:  Peter Knapp
Reviewer's report:
This is an interesting and potentially useful report of patient experience data in relation to  a
newly available diagnostic test for Barrett's oesophagus.
It compares those scoring in the lowest 11% of experience scores with the remaining participants.
Dividing the sample into 2 groups  is sensible. However, the mean score in the 'least positive'
group is 2.3, which is a long way below a mean of 5, which would  be the least positive mean
score that was available. The authors report the IQR but could they provide more data on the
numbers of participants who (for example) scored a mean of >3 or a mean of >4?
88% people managed the test + returned questionnaires. How many failed to manage the test
in total?
The authors report (ref 15) that completers and non-completers have been reported previously
- but what did these data show (in brief)?
In the discussion refs 25 and 26 are cited but these appear to show *the opposite* of what is
reported - ie  I think they show that higher satisfaction is associated with higher education level.
The relationships of experience with obesity and drinking frequency are not obvious to explain,
and these factors may well be proxies for other predictors.
The suggestions for preparation for the test, based on the study findings, seem sensible.
Tables 2 and 3 report the regression analyses. It's not clear why the unadjusted ORs are not
reported in Table 2 - can they be added?
I would suggest one small change to the abstract text: in the results change the text to "and more
frequent alcohol intake (p for trend = 0.010). "
A very picky point - in  Table 3 the OR for age (1.37) is missing its decimal point.
Title: Predictors of the experience of a Cytosponge test: analysis of patient survey data from
the BEST3 trial
Version: 2 Date: 15 Sep 2022
Reviewer:  Peter Knapp
Reviewer's report:
This is an interesting and potentially useful report of patient experience data in relation to  a
newly available diagnostic test for Barrett's oesophagus.
It compares those scoring in the lowest 11% of experience scores with the remaining participants.
Dividing the sample into 2 groups  is sensible. However, the mean score in the 'least positive'
group is 2.3, which is a long way below a mean of 5, which would  be the least positive mean
score that was available. The authors report the IQR but could they provide more data on the
numbers of participants who (for example) scored a mean of >3 or a mean of >4?
88% people managed the test + returned questionnaires. How many failed to manage the test
in total?
The authors report (ref 15) that completers and non-completers have been reported previously
- but what did these data show (in brief)?
In the discussion refs 25 and 26 are cited but these appear to show *the opposite* of what is
reported - ie  I think they show that higher satisfaction is associated with higher education level.
The relationships of experience with obesity and drinking frequency are not obvious to explain,
and these factors may well be proxies for other predictors.
The suggestions for preparation for the test, based on the study findings, seem sensible.
Tables 2 and 3 report the regression analyses. It's not clear why the unadjusted ORs are not
reported in Table 2 - can they be added?
I would suggest one small change to the abstract text: in the results change the text to "and more
frequent alcohol intake (p for trend = 0.010). "
A very picky point - in  Table 3 the OR for age (1.37) is missing its decimal point.
Please review this paper.
user
Title: Predictors of the experience of a Cytosponge test: analysis of patient survey data from
the BEST3 trial
Version: 2 Date: 15 Sep 2022
Reviewer:  Peter Knapp
Reviewer's report:
This is an interesting and potentially useful report of patient experience data in relation to  a
newly available diagnostic test for Barrett's oesophagus.
It compares those scoring in the lowest 11% of experience scores with the remaining participants.
Dividing the sample into 2 groups  is sensible. However, the mean score in the 'least positive'
group is 2.3, which is a long way below a mean of 5, which would  be the least positive mean
score that was available. The authors report the IQR but could they provide more data on the
numbers of participants who (for example) scored a mean of >3 or a mean of >4?
88% people managed the test + returned questionnaires. How many failed to manage the test
in total?
The authors report (ref 15) that completers and non-completers have been reported previously
- but what did these data show (in brief)?
In the discussion refs 25 and 26 are cited but these appear to show *the opposite* of what is
reported - ie  I think they show that higher satisfaction is associated with higher education level.
The relationships of experience with obesity and drinking frequency are not obvious to explain,
and these factors may well be proxies for other predictors.
The suggestions for preparation for the test, based on the study findings, seem sensible.
Tables 2 and 3 report the regression analyses. It's not clear why the unadjusted ORs are not
reported in Table 2 - can they be added?
I would suggest one small change to the abstract text: in the results change the text to "and more
frequent alcohol intake (p for trend = 0.010). "
A very picky point - in  Table 3 the OR for age (1.37) is missing its decimal point.
assistant