Title: Is Serum Albumin a Pivotal Biomarker in Anticipating Acute Pancreatitis Outcomes?
Version: 4 Date: 17 May 2024
Reviewer's report:
At present I could find these major issue in the manuscript.
1. Was research question defined before start of study?
• It is not clear from methodology.
• I think this was simply a retrospective audit of the patients presented in the department.
2. It was an expected outcome – as in any acute condition secondary to stress response albumin
level definitely expected low and its level further depends on severity of acute response.
• So basically it is effect of acute inflammation and it’s severity, not a cause for severe
pancreatitis. However to confirm this needs prospective studies.
My suggestion to authors: it may be useful to use ROC curve which may give better input
regarding at what cut-off value the complications significantly increase which give some thought
for use of albumin beneficial in decreasing complications.
Title: Is Serum Albumin a Pivotal Biomarker in Anticipating Acute Pancreatitis Outcomes?
Version: 4 Date: 17 May 2024
Reviewer's report:
At present I could find these major issue in the manuscript.
1. Was research question defined before start of study?
• It is not clear from methodology.
• I think this was simply a retrospective audit of the patients presented in the department.
2. It was an expected outcome – as in any acute condition secondary to stress response albumin
level definitely expected low and its level further depends on severity of acute response.
• So basically it is effect of acute inflammation and it’s severity, not a cause for severe
pancreatitis. However to confirm this needs prospective studies.
My suggestion to authors: it may be useful to use ROC curve which may give better input
regarding at what cut-off value the complications significantly increase which give some thought
for use of albumin beneficial in decreasing complications.
Please review this paper.
user
Title: Is Serum Albumin a Pivotal Biomarker in Anticipating Acute Pancreatitis Outcomes?
Version: 4 Date: 17 May 2024
Reviewer's report:
At present I could find these major issue in the manuscript.
1. Was research question defined before start of study?
• It is not clear from methodology.
• I think this was simply a retrospective audit of the patients presented in the department.
2. It was an expected outcome – as in any acute condition secondary to stress response albumin
level definitely expected low and its level further depends on severity of acute response.
• So basically it is effect of acute inflammation and it’s severity, not a cause for severe
pancreatitis. However to confirm this needs prospective studies.
My suggestion to authors: it may be useful to use ROC curve which may give better input
regarding at what cut-off value the complications significantly increase which give some thought
for use of albumin beneficial in decreasing complications.
assistant