Title: Association between colorectal cancer, the frequency of Bacteroides fragilis, and the
levels of mismatch repair genes expression in the biopsy samples of Iranian patients
Version: 2 Date: 25 Sep 2023
Reviewer's report:
Dear authors
The manuscript novelty is acceptable.
What does “MMR genes” mean in the abstract?
Introduction:
Please re-write “According to 2020 reports, 1.9 million people are globally each year (2, 3), and
since its lethality is also determined”.
The writing of the manuscript can be improved.
These manuscripts can be cited in the introduction:
Microbiome dysbiosis and predominant bacterial species as human cancer biomarkers. Journal
of gastrointestinal cancer. 2020 Sep;51:725-8.
Assessment of oncogenic role of intestinal microbiota in colorectal cancer patients. Journal of
gastrointestinal cancer. 2021 Sep;52:1016-21.
Probiotics and their increasing importance in human health and infection control. Reviews and
Research in Medical Microbiology. 2018 Oct 1;29(4):153-8.
Methods and results are good.
The discussion section is suitable, but recent studies from 2022 and 2023 can be added.
Kind regards
Title: Association between colorectal cancer, the frequency of Bacteroides fragilis, and the
levels of mismatch repair genes expression in the biopsy samples of Iranian patients
Version: 2 Date: 25 Sep 2023
Reviewer's report:
Dear authors
The manuscript novelty is acceptable.
What does “MMR genes” mean in the abstract?
Introduction:
Please re-write “According to 2020 reports, 1.9 million people are globally each year (2, 3), and
since its lethality is also determined”.
The writing of the manuscript can be improved.
These manuscripts can be cited in the introduction:
Microbiome dysbiosis and predominant bacterial species as human cancer biomarkers. Journal
of gastrointestinal cancer. 2020 Sep;51:725-8.
Assessment of oncogenic role of intestinal microbiota in colorectal cancer patients. Journal of
gastrointestinal cancer. 2021 Sep;52:1016-21.
Probiotics and their increasing importance in human health and infection control. Reviews and
Research in Medical Microbiology. 2018 Oct 1;29(4):153-8.
Methods and results are good.
The discussion section is suitable, but recent studies from 2022 and 2023 can be added.
Kind regards
Please review this paper.
user
Title: Association between colorectal cancer, the frequency of Bacteroides fragilis, and the
levels of mismatch repair genes expression in the biopsy samples of Iranian patients
Version: 2 Date: 25 Sep 2023
Reviewer's report:
Dear authors
The manuscript novelty is acceptable.
What does “MMR genes” mean in the abstract?
Introduction:
Please re-write “According to 2020 reports, 1.9 million people are globally each year (2, 3), and
since its lethality is also determined”.
The writing of the manuscript can be improved.
These manuscripts can be cited in the introduction:
Microbiome dysbiosis and predominant bacterial species as human cancer biomarkers. Journal
of gastrointestinal cancer. 2020 Sep;51:725-8.
Assessment of oncogenic role of intestinal microbiota in colorectal cancer patients. Journal of
gastrointestinal cancer. 2021 Sep;52:1016-21.
Probiotics and their increasing importance in human health and infection control. Reviews and
Research in Medical Microbiology. 2018 Oct 1;29(4):153-8.
Methods and results are good.
The discussion section is suitable, but recent studies from 2022 and 2023 can be added.
Kind regards
assistant