Reviewer's report
Title:Nine-year incident diabetes is predicted by fatty liver indices: The French
D.E.S.I.R. study
Version: 1Date:15 February 2010
Reviewer: Melania Manco
Reviewer's report:
Balkau and Coll. aim to verify the effectiveness of 2 recently developed
mathematical indexes to predict incident T2DM, the FLI and the NAFLD-FLS.
Both indexes use surrogates of the MetS and liver enzymes.
To accomplish their aim, the researchers use data from a large cohort study, the
DESIR. Incident diabetes was estimated using as markers prescription of anti
diabetic drugs and values of fasting PG #7.0 mmol/l.
In this context, the manuscript may deserve publication as background for future
epidemiological studies. I think the manuscript can be improved by discussing
the high OR for T2DM which was observed in women with a FLI >70 and/or by
discussing the utility of such indexes as compared with traditional risk factors.
The authors present some of these results in the table but there is no discussion.
Major comment:
1. The risk for diabetes was particularly high in women with a FLI >70 (OR 37).
This gender related effect deserves additional analysis and discussion, i.e. in
relation to an effect of the menopause.
2. Please, make clear which is the plus value of the FLI index or of the
NAFLD-FLS respect to common predictors of T2DM such as familiarity for the
disease. Do the indexes identify different samples of high-risk individuals as
compared with traditional risk factors?
Minor comments:
1. Bedogni and not Bedogini (page 3)
2. BMI and not (BM)I (page 3)
3. In the introduction there is no need to talk about CRP or NEFA or TNF-alpha
as these measures do not enter the FLI or the NAFLD-FLS scores. May be the
authors want to highlight the concept that the NAFLD can be considered the
hepatic component of the MetS and that component of the syndrome enter both
the indexes.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Nine-year incident diabetes is predicted by fatty liver indices: The French
D.E.S.I.R. study
Version: 1Date:15 February 2010
Reviewer: Melania Manco
Reviewer's report:
Balkau and Coll. aim to verify the effectiveness of 2 recently developed
mathematical indexes to predict incident T2DM, the FLI and the NAFLD-FLS.
Both indexes use surrogates of the MetS and liver enzymes.
To accomplish their aim, the researchers use data from a large cohort study, the
DESIR. Incident diabetes was estimated using as markers prescription of anti
diabetic drugs and values of fasting PG #7.0 mmol/l.
In this context, the manuscript may deserve publication as background for future
epidemiological studies. I think the manuscript can be improved by discussing
the high OR for T2DM which was observed in women with a FLI >70 and/or by
discussing the utility of such indexes as compared with traditional risk factors.
The authors present some of these results in the table but there is no discussion.
Major comment:
1. The risk for diabetes was particularly high in women with a FLI >70 (OR 37).
This gender related effect deserves additional analysis and discussion, i.e. in
relation to an effect of the menopause.
2. Please, make clear which is the plus value of the FLI index or of the
NAFLD-FLS respect to common predictors of T2DM such as familiarity for the
disease. Do the indexes identify different samples of high-risk individuals as
compared with traditional risk factors?
Minor comments:
1. Bedogni and not Bedogini (page 3)
2. BMI and not (BM)I (page 3)
3. In the introduction there is no need to talk about CRP or NEFA or TNF-alpha
as these measures do not enter the FLI or the NAFLD-FLS scores. May be the
authors want to highlight the concept that the NAFLD can be considered the
hepatic component of the MetS and that component of the syndrome enter both
the indexes.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Nine-year incident diabetes is predicted by fatty liver indices: The French
D.E.S.I.R. study
Version: 1Date:15 February 2010
Reviewer: Melania Manco
Reviewer's report:
Balkau and Coll. aim to verify the effectiveness of 2 recently developed
mathematical indexes to predict incident T2DM, the FLI and the NAFLD-FLS.
Both indexes use surrogates of the MetS and liver enzymes.
To accomplish their aim, the researchers use data from a large cohort study, the
DESIR. Incident diabetes was estimated using as markers prescription of anti
diabetic drugs and values of fasting PG #7.0 mmol/l.
In this context, the manuscript may deserve publication as background for future
epidemiological studies. I think the manuscript can be improved by discussing
the high OR for T2DM which was observed in women with a FLI >70 and/or by
discussing the utility of such indexes as compared with traditional risk factors.
The authors present some of these results in the table but there is no discussion.
Major comment:
1. The risk for diabetes was particularly high in women with a FLI >70 (OR 37).
This gender related effect deserves additional analysis and discussion, i.e. in
relation to an effect of the menopause.
2. Please, make clear which is the plus value of the FLI index or of the
NAFLD-FLS respect to common predictors of T2DM such as familiarity for the
disease. Do the indexes identify different samples of high-risk individuals as
compared with traditional risk factors?
Minor comments:
1. Bedogni and not Bedogini (page 3)
2. BMI and not (BM)I (page 3)
3. In the introduction there is no need to talk about CRP or NEFA or TNF-alpha
as these measures do not enter the FLI or the NAFLD-FLS scores. May be the
authors want to highlight the concept that the NAFLD can be considered the
hepatic component of the MetS and that component of the syndrome enter both
the indexes.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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