Title: Efficacy and Safety of Chemoradiation Therapy Using One- Shot Cisplatin via Hepatic
Arterial Infusion for Advanced Hepatocellular Carcinoma with Major Macrovascular Invasion:
a Single-arm Retrospective Cohort Study
Version: 1 Date: 19 Feb 2022
Reviewer's report:
The author reported the efficacy of chemoradiation therapy using One-Shot Cisplatin for
Advanced Hepatocellular Carcinoma with Major Macrovascular Invasion. This regimen is an
important strategy for unresectable HCC with macrovascular invasion. However, there were
serious problems in this manuscript.
(1). Author mentioned that “Therefore, this study aimed to evaluate the safety and
efficacy of one-shot CDDP via HAI combined with RT for patients before systemic
chemotherapy.” (Introduction, Page 2, line 62-63). But, many people with poor liver function
(Child-Pugh class B, or ALBI grade 3) are registered in this study. Indication for systemic
chemotherapy is good liver function.
(2). In Figure 2, the number of PR patients is 20, However, the number of PR patients is 19.
Please clarify.
Title: Efficacy and Safety of Chemoradiation Therapy Using One- Shot Cisplatin via Hepatic
Arterial Infusion for Advanced Hepatocellular Carcinoma with Major Macrovascular Invasion:
a Single-arm Retrospective Cohort Study
Version: 1 Date: 19 Feb 2022
Reviewer's report:
The author reported the efficacy of chemoradiation therapy using One-Shot Cisplatin for
Advanced Hepatocellular Carcinoma with Major Macrovascular Invasion. This regimen is an
important strategy for unresectable HCC with macrovascular invasion. However, there were
serious problems in this manuscript.
(1). Author mentioned that “Therefore, this study aimed to evaluate the safety and
efficacy of one-shot CDDP via HAI combined with RT for patients before systemic
chemotherapy.” (Introduction, Page 2, line 62-63). But, many people with poor liver function
(Child-Pugh class B, or ALBI grade 3) are registered in this study. Indication for systemic
chemotherapy is good liver function.
(2). In Figure 2, the number of PR patients is 20, However, the number of PR patients is 19.
Please clarify.
Please review this paper.
user
Title: Efficacy and Safety of Chemoradiation Therapy Using One- Shot Cisplatin via Hepatic
Arterial Infusion for Advanced Hepatocellular Carcinoma with Major Macrovascular Invasion:
a Single-arm Retrospective Cohort Study
Version: 1 Date: 19 Feb 2022
Reviewer's report:
The author reported the efficacy of chemoradiation therapy using One-Shot Cisplatin for
Advanced Hepatocellular Carcinoma with Major Macrovascular Invasion. This regimen is an
important strategy for unresectable HCC with macrovascular invasion. However, there were
serious problems in this manuscript.
(1). Author mentioned that “Therefore, this study aimed to evaluate the safety and
efficacy of one-shot CDDP via HAI combined with RT for patients before systemic
chemotherapy.” (Introduction, Page 2, line 62-63). But, many people with poor liver function
(Child-Pugh class B, or ALBI grade 3) are registered in this study. Indication for systemic
chemotherapy is good liver function.
(2). In Figure 2, the number of PR patients is 20, However, the number of PR patients is 19.
Please clarify.
assistant