Title: Host cytokine genetic polymorphisms in a selected population of persons living with
hepatitis B virus infection in the Central Region of Ghana
Version: 2 Date: 15 Jul 2024
Reviewer's report:
Report on Host cytokine genetic polymorphisms in a selected population of persons living with
hepatitis B virus infection in the Central Region of Ghana
introduction
What is the difference between liver disease and liver cancer
Too  many unnecessary repetitions: infection is a public health concern in sub-Sahara Africa
(SSA); infections occur in Eastern and Sub-Saharan Africa; occur in the African region ?????.
Where is realy HBV?
Cytokines were already talked off in the first paragraph of the introduction. Why come now
to reintroduce cytokines afresh in the next paragraph? The introduction looks like pieces of
information cut and pasted without any coherence and a lot of repetition.
Materials and methods: OK
Results:
Tables 1& 2  talk of many parameters that were not announced in the introduction  It’s not
understood their role in the work. Does marital status, BMI, Alcohol,  education etc affect the
development of hepatitis B?. If yes, Please indicate in the introduction how these numerous
parameters in tables 1 &2 have been found to  affect HBV infection. The title of the work is
genetic polymorphisms and the work should be focused on this
Table 2 talks of clinical & anthropometric factors: Which are the anthropometric data in the
table?. I do not see.
Various ethnic groups were considered in this work. What is the frequency distribution of
cytokine genotypes in various ethnic groups in the country?
Table 5:  Comparison of variant allele frequency with other populations: Where are the values
from? Did authors work with Asians, Americans?
Title: Host cytokine genetic polymorphisms in a selected population of persons living with
hepatitis B virus infection in the Central Region of Ghana
Version: 2 Date: 15 Jul 2024
Reviewer's report:
Report on Host cytokine genetic polymorphisms in a selected population of persons living with
hepatitis B virus infection in the Central Region of Ghana
introduction
What is the difference between liver disease and liver cancer
Too  many unnecessary repetitions: infection is a public health concern in sub-Sahara Africa
(SSA); infections occur in Eastern and Sub-Saharan Africa; occur in the African region ?????.
Where is realy HBV?
Cytokines were already talked off in the first paragraph of the introduction. Why come now
to reintroduce cytokines afresh in the next paragraph? The introduction looks like pieces of
information cut and pasted without any coherence and a lot of repetition.
Materials and methods: OK
Results:
Tables 1& 2  talk of many parameters that were not announced in the introduction  It’s not
understood their role in the work. Does marital status, BMI, Alcohol,  education etc affect the
development of hepatitis B?. If yes, Please indicate in the introduction how these numerous
parameters in tables 1 &2 have been found to  affect HBV infection. The title of the work is
genetic polymorphisms and the work should be focused on this
Table 2 talks of clinical & anthropometric factors: Which are the anthropometric data in the
table?. I do not see.
Various ethnic groups were considered in this work. What is the frequency distribution of
cytokine genotypes in various ethnic groups in the country?
Table 5:  Comparison of variant allele frequency with other populations: Where are the values
from? Did authors work with Asians, Americans?
Please review this paper.
user
Title: Host cytokine genetic polymorphisms in a selected population of persons living with
hepatitis B virus infection in the Central Region of Ghana
Version: 2 Date: 15 Jul 2024
Reviewer's report:
Report on Host cytokine genetic polymorphisms in a selected population of persons living with
hepatitis B virus infection in the Central Region of Ghana
introduction
What is the difference between liver disease and liver cancer
Too  many unnecessary repetitions: infection is a public health concern in sub-Sahara Africa
(SSA); infections occur in Eastern and Sub-Saharan Africa; occur in the African region ?????.
Where is realy HBV?
Cytokines were already talked off in the first paragraph of the introduction. Why come now
to reintroduce cytokines afresh in the next paragraph? The introduction looks like pieces of
information cut and pasted without any coherence and a lot of repetition.
Materials and methods: OK
Results:
Tables 1& 2  talk of many parameters that were not announced in the introduction  It’s not
understood their role in the work. Does marital status, BMI, Alcohol,  education etc affect the
development of hepatitis B?. If yes, Please indicate in the introduction how these numerous
parameters in tables 1 &2 have been found to  affect HBV infection. The title of the work is
genetic polymorphisms and the work should be focused on this
Table 2 talks of clinical & anthropometric factors: Which are the anthropometric data in the
table?. I do not see.
Various ethnic groups were considered in this work. What is the frequency distribution of
cytokine genotypes in various ethnic groups in the country?
Table 5:  Comparison of variant allele frequency with other populations: Where are the values
from? Did authors work with Asians, Americans?
assistant