Reviewer's report
Title:Likelihood of complete response for advanced liver cancer during sorafenib
therapy: Case Report
Version: 2Date:20 September 2010
Reviewer: Lorenza Rimassa
Reviewer's report:
The paper reports a case of complete response to sorafenib in a patients with
advanced HCV-related hepatocellular carcinoma.
Notwithstanding the limits of a case report, it could be of some interest due to the
few published data, the limited therapeutic options and the poor prognosis of
these patients.
The Authors point out and argue some interesting aspects of this case, as the old
age of the patient, the achieved complete response, the good tolerability of
sorafenib, the activity of the drug on the portal vein thrombosis and the reduction
of metallo-proteinase serum levels during the treatment. A minor limit of this case
is the lack of a tumor biopsy at diagnosis and during the treatment.
Minor Essential Revisions
The main limit of this paper consists in the English language that does not seem
very accurate and needs an extensive editing.
In conclusion, I think the paper could be of some interest but it needs major
editing review before it could be published.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Likelihood of complete response for advanced liver cancer during sorafenib
therapy: Case Report
Version: 2Date:20 September 2010
Reviewer: Lorenza Rimassa
Reviewer's report:
The paper reports a case of complete response to sorafenib in a patients with
advanced HCV-related hepatocellular carcinoma.
Notwithstanding the limits of a case report, it could be of some interest due to the
few published data, the limited therapeutic options and the poor prognosis of
these patients.
The Authors point out and argue some interesting aspects of this case, as the old
age of the patient, the achieved complete response, the good tolerability of
sorafenib, the activity of the drug on the portal vein thrombosis and the reduction
of metallo-proteinase serum levels during the treatment. A minor limit of this case
is the lack of a tumor biopsy at diagnosis and during the treatment.
Minor Essential Revisions
The main limit of this paper consists in the English language that does not seem
very accurate and needs an extensive editing.
In conclusion, I think the paper could be of some interest but it needs major
editing review before it could be published.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Likelihood of complete response for advanced liver cancer during sorafenib
therapy: Case Report
Version: 2Date:20 September 2010
Reviewer: Lorenza Rimassa
Reviewer's report:
The paper reports a case of complete response to sorafenib in a patients with
advanced HCV-related hepatocellular carcinoma.
Notwithstanding the limits of a case report, it could be of some interest due to the
few published data, the limited therapeutic options and the poor prognosis of
these patients.
The Authors point out and argue some interesting aspects of this case, as the old
age of the patient, the achieved complete response, the good tolerability of
sorafenib, the activity of the drug on the portal vein thrombosis and the reduction
of metallo-proteinase serum levels during the treatment. A minor limit of this case
is the lack of a tumor biopsy at diagnosis and during the treatment.
Minor Essential Revisions
The main limit of this paper consists in the English language that does not seem
very accurate and needs an extensive editing.
In conclusion, I think the paper could be of some interest but it needs major
editing review before it could be published.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant