Title: A novel nomogram for identifying candidates for adjuvant chemotherapy in patients with
stage IB gastric adenocarcinoma
Version: 3 Date: 13 Oct 2022
Reviewer's report:
The authors have not answered the following questions, so I cannot accept this paper.
6. Given the results of this paper, it is hard to reach the conclusion. The authors
should perform below-mentioned survival analysis. First, the authors should divide
3 groups (low, intermediate, high) based on total points obtained by nomogram. The
authors should draw Kaplan-Meier survival curves in each risk group.
Response: According to your idea, I made further analysis using x-tile and divided
all the patients into three groups (low, intermediate, high) based on the total points
obtained by nomogram. The cut-off points were 99 and 133. However, there were no
significant outcomes. So, I don't think this is an effective method in this study. In this
article, we constructed a predictive nomogram to identify potential ACT-beneficial
cases based on the multivariable logistic regression model. The total score was
calculated by summing the scores corresponding to the six parameters. Then the model
could be used to predict the beneficial probability of ACT.  So I think this was a better
way than the risk-stratification method in this research.
Title: A novel nomogram for identifying candidates for adjuvant chemotherapy in patients with
stage IB gastric adenocarcinoma
Version: 3 Date: 13 Oct 2022
Reviewer's report:
The authors have not answered the following questions, so I cannot accept this paper.
6. Given the results of this paper, it is hard to reach the conclusion. The authors
should perform below-mentioned survival analysis. First, the authors should divide
3 groups (low, intermediate, high) based on total points obtained by nomogram. The
authors should draw Kaplan-Meier survival curves in each risk group.
Response: According to your idea, I made further analysis using x-tile and divided
all the patients into three groups (low, intermediate, high) based on the total points
obtained by nomogram. The cut-off points were 99 and 133. However, there were no
significant outcomes. So, I don't think this is an effective method in this study. In this
article, we constructed a predictive nomogram to identify potential ACT-beneficial
cases based on the multivariable logistic regression model. The total score was
calculated by summing the scores corresponding to the six parameters. Then the model
could be used to predict the beneficial probability of ACT.  So I think this was a better
way than the risk-stratification method in this research.
Please review this paper.
user
Title: A novel nomogram for identifying candidates for adjuvant chemotherapy in patients with
stage IB gastric adenocarcinoma
Version: 3 Date: 13 Oct 2022
Reviewer's report:
The authors have not answered the following questions, so I cannot accept this paper.
6. Given the results of this paper, it is hard to reach the conclusion. The authors
should perform below-mentioned survival analysis. First, the authors should divide
3 groups (low, intermediate, high) based on total points obtained by nomogram. The
authors should draw Kaplan-Meier survival curves in each risk group.
Response: According to your idea, I made further analysis using x-tile and divided
all the patients into three groups (low, intermediate, high) based on the total points
obtained by nomogram. The cut-off points were 99 and 133. However, there were no
significant outcomes. So, I don't think this is an effective method in this study. In this
article, we constructed a predictive nomogram to identify potential ACT-beneficial
cases based on the multivariable logistic regression model. The total score was
calculated by summing the scores corresponding to the six parameters. Then the model
could be used to predict the beneficial probability of ACT.  So I think this was a better
way than the risk-stratification method in this research.
assistant