Reviewer's report
Title:Antiulcer activity of fluvoxamine in rats and its effect on oxidant and
antioxidant parameters in stomach tissue
Version: 2Date:12 January 2009
Reviewer: Jonathan Kaunitz
Reviewer's report:
Using a standard rat indomethacin ulcer model, the authors report the
fluvoxamine, a drug used in the treatment of obsessive-compulsive disorder,
prevents acute ulcer formation. Furthermore, the drug appears to have
anti-oxidant effects, increasing the production of NO and GSH, while diminishing
the production of MDA and MPO.
Major Compulsory Revisions:
1. The doses of fluvoxamine used (50-200 mg/kg) are far greater than those
used clinically, (1-5 mg/kg). The authors should hence point this out and interpret
their rat data with far more caution, avoding speculation about clinical translation.
2. Fluvoxamine is a CYP 1A2 inhibitor. CYP 1A are believed to generate ROS
(Cf. Mol Pharmacol. 1999 Sep;56(3):588-97) Could this be a possible
explanation for the data shown?
3. The data are depicted in a non-standard, redundant, and somewhat confusing
fashion. It is not necessary to have numerical data in the text and again in a
graph. Please add error bars to the graphs and omit the data from the text.
Furthermore, the data are described in the Results section in an order different to
what is shown in the graphs. Moreover, the use of the terms “intact” is confusing.
Suggest a row for indo, fluvoxamine and ranitidine dose under each graph, with
numbers representing the dose.
4. The figures with the gastric mucosa depict standard results and thus should be
deleted.
5. Please remove unsupported statements such as “The clinical efficacy of
antidepressant drugs…” on the 1st page of the Introduction.
6. Is distilled water the correct vehicle control?
7. Is it correct to statistically compare the “intact” (no indo) with the control
(indo)?
8. The second half of the 1st paragraph if the Discussion does not bear on the
data and should be deleted.
9. The last sentence of the text should be deleted.
Minor Essential Revisions:
1. Capitalization: Helicobacter
2. Please correct and edit for proprper English usage
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Antiulcer activity of fluvoxamine in rats and its effect on oxidant and
antioxidant parameters in stomach tissue
Version: 2Date:12 January 2009
Reviewer: Jonathan Kaunitz
Reviewer's report:
Using a standard rat indomethacin ulcer model, the authors report the
fluvoxamine, a drug used in the treatment of obsessive-compulsive disorder,
prevents acute ulcer formation. Furthermore, the drug appears to have
anti-oxidant effects, increasing the production of NO and GSH, while diminishing
the production of MDA and MPO.
Major Compulsory Revisions:
1. The doses of fluvoxamine used (50-200 mg/kg) are far greater than those
used clinically, (1-5 mg/kg). The authors should hence point this out and interpret
their rat data with far more caution, avoding speculation about clinical translation.
2. Fluvoxamine is a CYP 1A2 inhibitor. CYP 1A are believed to generate ROS
(Cf. Mol Pharmacol. 1999 Sep;56(3):588-97) Could this be a possible
explanation for the data shown?
3. The data are depicted in a non-standard, redundant, and somewhat confusing
fashion. It is not necessary to have numerical data in the text and again in a
graph. Please add error bars to the graphs and omit the data from the text.
Furthermore, the data are described in the Results section in an order different to
what is shown in the graphs. Moreover, the use of the terms “intact” is confusing.
Suggest a row for indo, fluvoxamine and ranitidine dose under each graph, with
numbers representing the dose.
4. The figures with the gastric mucosa depict standard results and thus should be
deleted.
5. Please remove unsupported statements such as “The clinical efficacy of
antidepressant drugs…” on the 1st page of the Introduction.
6. Is distilled water the correct vehicle control?
7. Is it correct to statistically compare the “intact” (no indo) with the control
(indo)?
8. The second half of the 1st paragraph if the Discussion does not bear on the
data and should be deleted.
9. The last sentence of the text should be deleted.
Minor Essential Revisions:
1. Capitalization: Helicobacter
2. Please correct and edit for proprper English usage
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Antiulcer activity of fluvoxamine in rats and its effect on oxidant and
antioxidant parameters in stomach tissue
Version: 2Date:12 January 2009
Reviewer: Jonathan Kaunitz
Reviewer's report:
Using a standard rat indomethacin ulcer model, the authors report the
fluvoxamine, a drug used in the treatment of obsessive-compulsive disorder,
prevents acute ulcer formation. Furthermore, the drug appears to have
anti-oxidant effects, increasing the production of NO and GSH, while diminishing
the production of MDA and MPO.
Major Compulsory Revisions:
1. The doses of fluvoxamine used (50-200 mg/kg) are far greater than those
used clinically, (1-5 mg/kg). The authors should hence point this out and interpret
their rat data with far more caution, avoding speculation about clinical translation.
2. Fluvoxamine is a CYP 1A2 inhibitor. CYP 1A are believed to generate ROS
(Cf. Mol Pharmacol. 1999 Sep;56(3):588-97) Could this be a possible
explanation for the data shown?
3. The data are depicted in a non-standard, redundant, and somewhat confusing
fashion. It is not necessary to have numerical data in the text and again in a
graph. Please add error bars to the graphs and omit the data from the text.
Furthermore, the data are described in the Results section in an order different to
what is shown in the graphs. Moreover, the use of the terms “intact” is confusing.
Suggest a row for indo, fluvoxamine and ranitidine dose under each graph, with
numbers representing the dose.
4. The figures with the gastric mucosa depict standard results and thus should be
deleted.
5. Please remove unsupported statements such as “The clinical efficacy of
antidepressant drugs…” on the 1st page of the Introduction.
6. Is distilled water the correct vehicle control?
7. Is it correct to statistically compare the “intact” (no indo) with the control
(indo)?
8. The second half of the 1st paragraph if the Discussion does not bear on the
data and should be deleted.
9. The last sentence of the text should be deleted.
Minor Essential Revisions:
1. Capitalization: Helicobacter
2. Please correct and edit for proprper English usage
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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