Title: Temporal trends in disability adjusted life year and mortality for colorectal cancer
attributable to a high red meat diet in China from 1990 to 2021: an analysis of the Global Burden
of Disease Study 2021
Version: 1 Date: 14 Oct 2024
Reviewer's report:
Thank you for the opportunity to review the work from Leiuet al, quite an interesting study,
here are minor comments
1. Author might consider discuss and analyze subgroup of early-onset colorectal cancer in Asia-
Pacific region including in China
suggested article include
https://pubmed.ncbi.nlm.nih.gov/37644698/
https://pubmed.ncbi.nlm.nih.gov/35116113/
https://pubmed.ncbi.nlm.nih.gov/30694865/
2. It would be highly beneficial if the author included the proportion of colorectal cancer in
relation to other gastrointestinal cancers, so readers might benefit from understanding how huge
the impact of CRC, suggested study including
https://pubmed.ncbi.nlm.nih.gov/39242191/
https://pubmed.ncbi.nlm.nih.gov/32247694/
3. Generally, GBD have the “data rating quality,” which shows how robust the data it is in that
country from 0-5, I think it could be highly beneficial for the author to add this information in
the supplementary material so readers, particularly policymakers, can make a decision on the
policy for CRC and read meat consumption accurately
4.  The author mentioned the sociodemographic index, my question is, which country is in which
category?
5. I think the burden from red meat is interesting, yet the author need to mention that these risk
factors could be confounded by other risk factors, such as metabolic risk rather than red meat
alone, smoking, or alcohol
Suggested reading included but not limited to
https://pubmed.ncbi.nlm.nih.gov/34579050/
https://pubmed.ncbi.nlm.nih.gov/35131406/
https://pubmed.ncbi.nlm.nih.gov/35000418/
https://pubmed.ncbi.nlm.nih.gov/38942169/
https://pubmed.ncbi.nlm.nih.gov/38808961/
https://pubmed.ncbi.nlm.nih.gov/25486405/
https://pubmed.ncbi.nlm.nih.gov/38029839/
https://pubmed.ncbi.nlm.nih.gov/38428708/
https://pubmed.ncbi.nlm.nih.gov/35333295/
6. Readers might benefit from understanding the GBD methodology, and the author might
consider include in supplementary material.
7. The difference between GBD and another cancer database should be included.
https://pubmed.ncbi.nlm.nih.gov/37750191/
8. How reliable is red meat consumption data? How the GBD extract these needed to be
mentioned. How much red mead consumption is defined?
Title: Temporal trends in disability adjusted life year and mortality for colorectal cancer
attributable to a high red meat diet in China from 1990 to 2021: an analysis of the Global Burden
of Disease Study 2021
Version: 1 Date: 14 Oct 2024
Reviewer's report:
Thank you for the opportunity to review the work from Leiuet al, quite an interesting study,
here are minor comments
1. Author might consider discuss and analyze subgroup of early-onset colorectal cancer in Asia-
Pacific region including in China
suggested article include
https://pubmed.ncbi.nlm.nih.gov/37644698/
https://pubmed.ncbi.nlm.nih.gov/35116113/
https://pubmed.ncbi.nlm.nih.gov/30694865/
2. It would be highly beneficial if the author included the proportion of colorectal cancer in
relation to other gastrointestinal cancers, so readers might benefit from understanding how huge
the impact of CRC, suggested study including
https://pubmed.ncbi.nlm.nih.gov/39242191/
https://pubmed.ncbi.nlm.nih.gov/32247694/
3. Generally, GBD have the “data rating quality,” which shows how robust the data it is in that
country from 0-5, I think it could be highly beneficial for the author to add this information in
the supplementary material so readers, particularly policymakers, can make a decision on the
policy for CRC and read meat consumption accurately
4.  The author mentioned the sociodemographic index, my question is, which country is in which
category?
5. I think the burden from red meat is interesting, yet the author need to mention that these risk
factors could be confounded by other risk factors, such as metabolic risk rather than red meat
alone, smoking, or alcohol
Suggested reading included but not limited to
https://pubmed.ncbi.nlm.nih.gov/34579050/
https://pubmed.ncbi.nlm.nih.gov/35131406/
https://pubmed.ncbi.nlm.nih.gov/35000418/
https://pubmed.ncbi.nlm.nih.gov/38942169/
https://pubmed.ncbi.nlm.nih.gov/38808961/
https://pubmed.ncbi.nlm.nih.gov/25486405/
https://pubmed.ncbi.nlm.nih.gov/38029839/
https://pubmed.ncbi.nlm.nih.gov/38428708/
https://pubmed.ncbi.nlm.nih.gov/35333295/
6. Readers might benefit from understanding the GBD methodology, and the author might
consider include in supplementary material.
7. The difference between GBD and another cancer database should be included.
https://pubmed.ncbi.nlm.nih.gov/37750191/
8. How reliable is red meat consumption data? How the GBD extract these needed to be
mentioned. How much red mead consumption is defined?
Please review this paper.
user
Title: Temporal trends in disability adjusted life year and mortality for colorectal cancer
attributable to a high red meat diet in China from 1990 to 2021: an analysis of the Global Burden
of Disease Study 2021
Version: 1 Date: 14 Oct 2024
Reviewer's report:
Thank you for the opportunity to review the work from Leiuet al, quite an interesting study,
here are minor comments
1. Author might consider discuss and analyze subgroup of early-onset colorectal cancer in Asia-
Pacific region including in China
suggested article include
https://pubmed.ncbi.nlm.nih.gov/37644698/
https://pubmed.ncbi.nlm.nih.gov/35116113/
https://pubmed.ncbi.nlm.nih.gov/30694865/
2. It would be highly beneficial if the author included the proportion of colorectal cancer in
relation to other gastrointestinal cancers, so readers might benefit from understanding how huge
the impact of CRC, suggested study including
https://pubmed.ncbi.nlm.nih.gov/39242191/
https://pubmed.ncbi.nlm.nih.gov/32247694/
3. Generally, GBD have the “data rating quality,” which shows how robust the data it is in that
country from 0-5, I think it could be highly beneficial for the author to add this information in
the supplementary material so readers, particularly policymakers, can make a decision on the
policy for CRC and read meat consumption accurately
4.  The author mentioned the sociodemographic index, my question is, which country is in which
category?
5. I think the burden from red meat is interesting, yet the author need to mention that these risk
factors could be confounded by other risk factors, such as metabolic risk rather than red meat
alone, smoking, or alcohol
Suggested reading included but not limited to
https://pubmed.ncbi.nlm.nih.gov/34579050/
https://pubmed.ncbi.nlm.nih.gov/35131406/
https://pubmed.ncbi.nlm.nih.gov/35000418/
https://pubmed.ncbi.nlm.nih.gov/38942169/
https://pubmed.ncbi.nlm.nih.gov/38808961/
https://pubmed.ncbi.nlm.nih.gov/25486405/
https://pubmed.ncbi.nlm.nih.gov/38029839/
https://pubmed.ncbi.nlm.nih.gov/38428708/
https://pubmed.ncbi.nlm.nih.gov/35333295/
6. Readers might benefit from understanding the GBD methodology, and the author might
consider include in supplementary material.
7. The difference between GBD and another cancer database should be included.
https://pubmed.ncbi.nlm.nih.gov/37750191/
8. How reliable is red meat consumption data? How the GBD extract these needed to be
mentioned. How much red mead consumption is defined?
assistant