Reviewer's report
Title:Small intestinal transit in patients with liver cirrhosis and portal
hypertension
Version: 1Date:17 October 2012
Reviewer: barbera roberta
Reviewer's report:
Maior Compulsory Revisions:
I read with interest the paper " small intestinal transit in patients with liver
cirrhosis and portal hypertension: a descriptive stydy" by S Karlsen and
coworkers.
The study evaluated gastrointestinal transit in cirrhotic patients, focusing in
particular on small bowel motility, using a novel methodology already applied by
the same Authors and for the same aim in other groups of patients (SSP, CF).
The hypothesis of a slower small bowel transit causing bacterial overgrowth and
subsequentely increased peritoneal bacterial translocation was not supported by
the results. The transit in fact in those patients was faster than in healthy
controls.
The research paper is well designed but the results are chaotically expressed. A
Table summarizing the motility data (gastric emptying small bowel and colonic
transit) ) in controls and patients is missing.
Moreover, the Figures are not explicatives of the results but are examples of the
novel method applied. In the discussion part, being results obtained not expected
by study hypothesis, very little is commendted on these conflicting data.
Figure 1 : not necessary becuase already extensively reported in previous recent
papers.
Figure 2: the legenda is not well definied (Patients or controls? fasting or after
meals? and wich meals, breakfasty or lunch?)
Figure 3: it is not clear form the text why the data are shown after 2 hours and
not at the end of the study.
figure 4 : it is not clear if this is an example of a patient or healthy control trace.
And all together it is not easy to folllow through colours.
Level of interest: An article of limited interest
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Small intestinal transit in patients with liver cirrhosis and portal
hypertension
Version: 1Date:17 October 2012
Reviewer: barbera roberta
Reviewer's report:
Maior Compulsory Revisions:
I read with interest the paper " small intestinal transit in patients with liver
cirrhosis and portal hypertension: a descriptive stydy" by S Karlsen and
coworkers.
The study evaluated gastrointestinal transit in cirrhotic patients, focusing in
particular on small bowel motility, using a novel methodology already applied by
the same Authors and for the same aim in other groups of patients (SSP, CF).
The hypothesis of a slower small bowel transit causing bacterial overgrowth and
subsequentely increased peritoneal bacterial translocation was not supported by
the results. The transit in fact in those patients was faster than in healthy
controls.
The research paper is well designed but the results are chaotically expressed. A
Table summarizing the motility data (gastric emptying small bowel and colonic
transit) ) in controls and patients is missing.
Moreover, the Figures are not explicatives of the results but are examples of the
novel method applied. In the discussion part, being results obtained not expected
by study hypothesis, very little is commendted on these conflicting data.
Figure 1 : not necessary becuase already extensively reported in previous recent
papers.
Figure 2: the legenda is not well definied (Patients or controls? fasting or after
meals? and wich meals, breakfasty or lunch?)
Figure 3: it is not clear form the text why the data are shown after 2 hours and
not at the end of the study.
figure 4 : it is not clear if this is an example of a patient or healthy control trace.
And all together it is not easy to folllow through colours.
Level of interest: An article of limited interest
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Small intestinal transit in patients with liver cirrhosis and portal
hypertension
Version: 1Date:17 October 2012
Reviewer: barbera roberta
Reviewer's report:
Maior Compulsory Revisions:
I read with interest the paper " small intestinal transit in patients with liver
cirrhosis and portal hypertension: a descriptive stydy" by S Karlsen and
coworkers.
The study evaluated gastrointestinal transit in cirrhotic patients, focusing in
particular on small bowel motility, using a novel methodology already applied by
the same Authors and for the same aim in other groups of patients (SSP, CF).
The hypothesis of a slower small bowel transit causing bacterial overgrowth and
subsequentely increased peritoneal bacterial translocation was not supported by
the results. The transit in fact in those patients was faster than in healthy
controls.
The research paper is well designed but the results are chaotically expressed. A
Table summarizing the motility data (gastric emptying small bowel and colonic
transit) ) in controls and patients is missing.
Moreover, the Figures are not explicatives of the results but are examples of the
novel method applied. In the discussion part, being results obtained not expected
by study hypothesis, very little is commendted on these conflicting data.
Figure 1 : not necessary becuase already extensively reported in previous recent
papers.
Figure 2: the legenda is not well definied (Patients or controls? fasting or after
meals? and wich meals, breakfasty or lunch?)
Figure 3: it is not clear form the text why the data are shown after 2 hours and
not at the end of the study.
figure 4 : it is not clear if this is an example of a patient or healthy control trace.
And all together it is not easy to folllow through colours.
Level of interest: An article of limited interest
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant