Title: Postoperative liver dysfunction is associated with poor long-term outcomes in patients
with colorectal cancer: a retrospective cohort study
Version: 0 Date: 21 Feb 2023
Reviewer's report:
1. The authors described that the grade of liver dysfunction was divided according to CTCAE's
diagnostic criteria.
1) However, there was no comment about CTCAE version. It is necessary to specify which
version of CTCAE was used for grading.
2) Furthermore, there is no grade of liver dysfunction according to liver enzyme in recent
CTCAE v5.0.
2. It would be better to change the exclusion criteria in the text to liver metastasis rather than
distant metastasis.
3. It would be desirable to show changes in liver enzymes in patients with liver dysfunction
after surgery.
4.. Factors affecting disease-free survival are lacking in pathologic factors such as lymphatic,
venous, and perineural invasion. In addition, In addition, it would be good to add the presence
or absence of adjuvant chemotherapy.
Title: Postoperative liver dysfunction is associated with poor long-term outcomes in patients
with colorectal cancer: a retrospective cohort study
Version: 0 Date: 21 Feb 2023
Reviewer's report:
1. The authors described that the grade of liver dysfunction was divided according to CTCAE's
diagnostic criteria.
1) However, there was no comment about CTCAE version. It is necessary to specify which
version of CTCAE was used for grading.
2) Furthermore, there is no grade of liver dysfunction according to liver enzyme in recent
CTCAE v5.0.
2. It would be better to change the exclusion criteria in the text to liver metastasis rather than
distant metastasis.
3. It would be desirable to show changes in liver enzymes in patients with liver dysfunction
after surgery.
4.. Factors affecting disease-free survival are lacking in pathologic factors such as lymphatic,
venous, and perineural invasion. In addition, In addition, it would be good to add the presence
or absence of adjuvant chemotherapy.
Please review this paper.
user
Title: Postoperative liver dysfunction is associated with poor long-term outcomes in patients
with colorectal cancer: a retrospective cohort study
Version: 0 Date: 21 Feb 2023
Reviewer's report:
1. The authors described that the grade of liver dysfunction was divided according to CTCAE's
diagnostic criteria.
1) However, there was no comment about CTCAE version. It is necessary to specify which
version of CTCAE was used for grading.
2) Furthermore, there is no grade of liver dysfunction according to liver enzyme in recent
CTCAE v5.0.
2. It would be better to change the exclusion criteria in the text to liver metastasis rather than
distant metastasis.
3. It would be desirable to show changes in liver enzymes in patients with liver dysfunction
after surgery.
4.. Factors affecting disease-free survival are lacking in pathologic factors such as lymphatic,
venous, and perineural invasion. In addition, In addition, it would be good to add the presence
or absence of adjuvant chemotherapy.
assistant