Reviewer's report
Title:Risk of esophagus cancer in diabetes mellitus: A population-based
case-control study in Taiwan
Version: 2Date:14 November 2012
Reviewer: Jennifer Drahos
Reviewer's report:
The authors edits have substantially improved and focused the manuscript. They
have sufficiently answered my questions and concerns point-by-point.The study
still suffers from not having the histological information on the esophageal
cancers, but the authors have stated the limitation and implications more clearly.
The methods and data are sound. The last section of the discussion on
anti-diabetic drugs is still somewhat confusing and unclear. The small number of
EC cases who were diabetic may represent adenocarinomas, since obesity is a
strong risk factor for this subtype. Once again, the lack of histology information is
a major concern for interpretation of their results. The title and abstract
accurately convey what was found, however, "Esophagus cancer" should be
changed to "Esophageal cancer". The manuscript would benefit from further
editing before consideration for publication.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Risk of esophagus cancer in diabetes mellitus: A population-based
case-control study in Taiwan
Version: 2Date:14 November 2012
Reviewer: Jennifer Drahos
Reviewer's report:
The authors edits have substantially improved and focused the manuscript. They
have sufficiently answered my questions and concerns point-by-point.The study
still suffers from not having the histological information on the esophageal
cancers, but the authors have stated the limitation and implications more clearly.
The methods and data are sound. The last section of the discussion on
anti-diabetic drugs is still somewhat confusing and unclear. The small number of
EC cases who were diabetic may represent adenocarinomas, since obesity is a
strong risk factor for this subtype. Once again, the lack of histology information is
a major concern for interpretation of their results. The title and abstract
accurately convey what was found, however, "Esophagus cancer" should be
changed to "Esophageal cancer". The manuscript would benefit from further
editing before consideration for publication.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Risk of esophagus cancer in diabetes mellitus: A population-based
case-control study in Taiwan
Version: 2Date:14 November 2012
Reviewer: Jennifer Drahos
Reviewer's report:
The authors edits have substantially improved and focused the manuscript. They
have sufficiently answered my questions and concerns point-by-point.The study
still suffers from not having the histological information on the esophageal
cancers, but the authors have stated the limitation and implications more clearly.
The methods and data are sound. The last section of the discussion on
anti-diabetic drugs is still somewhat confusing and unclear. The small number of
EC cases who were diabetic may represent adenocarinomas, since obesity is a
strong risk factor for this subtype. Once again, the lack of histology information is
a major concern for interpretation of their results. The title and abstract
accurately convey what was found, however, "Esophagus cancer" should be
changed to "Esophageal cancer". The manuscript would benefit from further
editing before consideration for publication.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant