Title: Corticosteroid suppresses urea-cycle-related gene expressions in ornithine
transcarbamylase deficiency
Version: 4 Date: 22 Jan 2022
Reviewer's report:
The author adequately responded to the questions raised by the reviewer in the first draft.
The reviewer thinks the authors are requested to answer one more question before this  paper
is published in BMC Gastroenterology.
The author states “ARG1 mRNA expression level in Otcspf-ash mice may have been decreased
as compensation for the decrease of ornithine level” (p16, lines 13-15).
OTCD patients generally need a higher ornithine concentration than healthy individuals to
maximize limited citrulline synthesis. For this reason, it seems to the reviewer that OTCD
individuals (both human and mouse) are expected to have high ARG1 activity to supply enough
ornithine.
Title: Corticosteroid suppresses urea-cycle-related gene expressions in ornithine
transcarbamylase deficiency
Version: 4 Date: 22 Jan 2022
Reviewer's report:
The author adequately responded to the questions raised by the reviewer in the first draft.
The reviewer thinks the authors are requested to answer one more question before this  paper
is published in BMC Gastroenterology.
The author states “ARG1 mRNA expression level in Otcspf-ash mice may have been decreased
as compensation for the decrease of ornithine level” (p16, lines 13-15).
OTCD patients generally need a higher ornithine concentration than healthy individuals to
maximize limited citrulline synthesis. For this reason, it seems to the reviewer that OTCD
individuals (both human and mouse) are expected to have high ARG1 activity to supply enough
ornithine.
Please review this paper.
user
Title: Corticosteroid suppresses urea-cycle-related gene expressions in ornithine
transcarbamylase deficiency
Version: 4 Date: 22 Jan 2022
Reviewer's report:
The author adequately responded to the questions raised by the reviewer in the first draft.
The reviewer thinks the authors are requested to answer one more question before this  paper
is published in BMC Gastroenterology.
The author states “ARG1 mRNA expression level in Otcspf-ash mice may have been decreased
as compensation for the decrease of ornithine level” (p16, lines 13-15).
OTCD patients generally need a higher ornithine concentration than healthy individuals to
maximize limited citrulline synthesis. For this reason, it seems to the reviewer that OTCD
individuals (both human and mouse) are expected to have high ARG1 activity to supply enough
ornithine.
assistant