Reviewer's report
Title:Multi-susceptibility genes associated with the risk of the development
stages of esophageal squamous cell cancer in Feicheng County
Version: 2Date:9 April 2011
Reviewer: Fumiaki Tanaka
Reviewer's report:
COMMENTS
The authors report in this manuscript that they examined that the association of
the ALDH2 and MTHFR polymorphisms is important in carcinogenesis of ESC in
Feicheng County, China.
The authors made some important changes following reviewers’ comments. This
manuscript contains potentially interesting facts that could be utilized for
understanding the mechanisms of the carcinogenesis of esophageal cancer in
Feicheng County, China. However, this reviewer need to raise concerns listed
below.
Major concerns:
1. As I mentioned in the previous review, conducting the analysis of
polymorphisms of toward carcinogenesis, the number of this study was too small
to obtain the conclusion. More than thousand patients and healthy controls would
be needed. This paper indicated just a sample of a county in China.
2. Page 14, the first paragraph, “This finding will be of great benefit to ~”. Which
country can pay for detecting ESC candidate in the world? This sentence needs
be deleted or changed.
3. Page 12, line 8-9, This sentence is wrong. Caucasians predominantly have
ALDH2*1.
Minor concerns:
1. Some words are not suitable for scientific manuscript. Page 4- line 11,
“excellent”, page 11-line 14, “that should be emphasized”, page 14-line 6, “great”
and so on,
2. Page 14, last paragraph, This paragraph has no informative information
regarding this article.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Multi-susceptibility genes associated with the risk of the development
stages of esophageal squamous cell cancer in Feicheng County
Version: 2Date:9 April 2011
Reviewer: Fumiaki Tanaka
Reviewer's report:
COMMENTS
The authors report in this manuscript that they examined that the association of
the ALDH2 and MTHFR polymorphisms is important in carcinogenesis of ESC in
Feicheng County, China.
The authors made some important changes following reviewers’ comments. This
manuscript contains potentially interesting facts that could be utilized for
understanding the mechanisms of the carcinogenesis of esophageal cancer in
Feicheng County, China. However, this reviewer need to raise concerns listed
below.
Major concerns:
1. As I mentioned in the previous review, conducting the analysis of
polymorphisms of toward carcinogenesis, the number of this study was too small
to obtain the conclusion. More than thousand patients and healthy controls would
be needed. This paper indicated just a sample of a county in China.
2. Page 14, the first paragraph, “This finding will be of great benefit to ~”. Which
country can pay for detecting ESC candidate in the world? This sentence needs
be deleted or changed.
3. Page 12, line 8-9, This sentence is wrong. Caucasians predominantly have
ALDH2*1.
Minor concerns:
1. Some words are not suitable for scientific manuscript. Page 4- line 11,
“excellent”, page 11-line 14, “that should be emphasized”, page 14-line 6, “great”
and so on,
2. Page 14, last paragraph, This paragraph has no informative information
regarding this article.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Multi-susceptibility genes associated with the risk of the development
stages of esophageal squamous cell cancer in Feicheng County
Version: 2Date:9 April 2011
Reviewer: Fumiaki Tanaka
Reviewer's report:
COMMENTS
The authors report in this manuscript that they examined that the association of
the ALDH2 and MTHFR polymorphisms is important in carcinogenesis of ESC in
Feicheng County, China.
The authors made some important changes following reviewers’ comments. This
manuscript contains potentially interesting facts that could be utilized for
understanding the mechanisms of the carcinogenesis of esophageal cancer in
Feicheng County, China. However, this reviewer need to raise concerns listed
below.
Major concerns:
1. As I mentioned in the previous review, conducting the analysis of
polymorphisms of toward carcinogenesis, the number of this study was too small
to obtain the conclusion. More than thousand patients and healthy controls would
be needed. This paper indicated just a sample of a county in China.
2. Page 14, the first paragraph, “This finding will be of great benefit to ~”. Which
country can pay for detecting ESC candidate in the world? This sentence needs
be deleted or changed.
3. Page 12, line 8-9, This sentence is wrong. Caucasians predominantly have
ALDH2*1.
Minor concerns:
1. Some words are not suitable for scientific manuscript. Page 4- line 11,
“excellent”, page 11-line 14, “that should be emphasized”, page 14-line 6, “great”
and so on,
2. Page 14, last paragraph, This paragraph has no informative information
regarding this article.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
assistant