Title: Models to predict the short-term survival of acute-on-chronic liver failure patients
following liver transplantation
Version: 1 Date: 08 Dec 2021
Reviewer's report:
Summary of research:
Yang and co-authors reported here the results of a retrospective study in which they investigated
the application of different ML models to predict short-term outcomes in ACLF patients
following LT.
Comments to the Author:
In my opinion, there are some minor corrections to be done:
1) On page 4, line 77: the authors report about some recent studies investigating the use of ML
models in the LT setting. While the validation study by Alyllon et al. 2018 is correctly cited,
there’s no mention regarding the original study of Briceno et al. from 2014, which should be
in my opinion added.
2) On page 4, line 77: “my team” should be changed with “our team”. On page 7, line 140
“performed to obtain” instead of “performed obtain”. On page 12, line 257: “methods to predict”
instead of “methods to predicting”.
3) Although on page 8, line 159 death within 90 days after LT is mentioned to define the two
groups (survival vs death), if the “short-term” evaluation is the main object of this study as it
is supposed to be, a proper definition of short-term should be provided previously within the
methods section.
4) I found a little bit confounding on page 13, line 277 where 5 parameters are reported to be
the selected preoperative variables of the study, but finally you list 6. Please specify it clearly
here (LYM vs NEUT, or both?).
Title: Models to predict the short-term survival of acute-on-chronic liver failure patients
following liver transplantation
Version: 1 Date: 08 Dec 2021
Reviewer's report:
Summary of research:
Yang and co-authors reported here the results of a retrospective study in which they investigated
the application of different ML models to predict short-term outcomes in ACLF patients
following LT.
Comments to the Author:
In my opinion, there are some minor corrections to be done:
1) On page 4, line 77: the authors report about some recent studies investigating the use of ML
models in the LT setting. While the validation study by Alyllon et al. 2018 is correctly cited,
there’s no mention regarding the original study of Briceno et al. from 2014, which should be
in my opinion added.
2) On page 4, line 77: “my team” should be changed with “our team”. On page 7, line 140
“performed to obtain” instead of “performed obtain”. On page 12, line 257: “methods to predict”
instead of “methods to predicting”.
3) Although on page 8, line 159 death within 90 days after LT is mentioned to define the two
groups (survival vs death), if the “short-term” evaluation is the main object of this study as it
is supposed to be, a proper definition of short-term should be provided previously within the
methods section.
4) I found a little bit confounding on page 13, line 277 where 5 parameters are reported to be
the selected preoperative variables of the study, but finally you list 6. Please specify it clearly
here (LYM vs NEUT, or both?).
Please review this paper.
user
Title: Models to predict the short-term survival of acute-on-chronic liver failure patients
following liver transplantation
Version: 1 Date: 08 Dec 2021
Reviewer's report:
Summary of research:
Yang and co-authors reported here the results of a retrospective study in which they investigated
the application of different ML models to predict short-term outcomes in ACLF patients
following LT.
Comments to the Author:
In my opinion, there are some minor corrections to be done:
1) On page 4, line 77: the authors report about some recent studies investigating the use of ML
models in the LT setting. While the validation study by Alyllon et al. 2018 is correctly cited,
there’s no mention regarding the original study of Briceno et al. from 2014, which should be
in my opinion added.
2) On page 4, line 77: “my team” should be changed with “our team”. On page 7, line 140
“performed to obtain” instead of “performed obtain”. On page 12, line 257: “methods to predict”
instead of “methods to predicting”.
3) Although on page 8, line 159 death within 90 days after LT is mentioned to define the two
groups (survival vs death), if the “short-term” evaluation is the main object of this study as it
is supposed to be, a proper definition of short-term should be provided previously within the
methods section.
4) I found a little bit confounding on page 13, line 277 where 5 parameters are reported to be
the selected preoperative variables of the study, but finally you list 6. Please specify it clearly
here (LYM vs NEUT, or both?).
assistant