Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 5 Date: 20 Jun 2022
Reviewer's report:
Thank you for your modifications. Although there is a disagreement about the analysis method
still remained, I think it is OK because the ROC curve, sensitivity and specificity for the
prediction of severe AP have been added and well discussed.
Now there are a couple of minor revisions required.
• Please describe the clinical significance about the utility of serum sTim-3 as an indicator of
severity in the early phase of AP not only as an early predictor for SAP in discussion section.
• On line 8 of the discussion section, please delete ‘and more accurate’. The presented data did
not show that predictive value of serum sTim-3 was more accurate as compared with those of
BISAP, APACHE II, and MCTSI score.
• There are two different abbreviations for soluble T-Cell immunoglobulin mucin domain-3 in
the text, sTIM-3 and sTim-3.
Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 5 Date: 20 Jun 2022
Reviewer's report:
Thank you for your modifications. Although there is a disagreement about the analysis method
still remained, I think it is OK because the ROC curve, sensitivity and specificity for the
prediction of severe AP have been added and well discussed.
Now there are a couple of minor revisions required.
• Please describe the clinical significance about the utility of serum sTim-3 as an indicator of
severity in the early phase of AP not only as an early predictor for SAP in discussion section.
• On line 8 of the discussion section, please delete ‘and more accurate’. The presented data did
not show that predictive value of serum sTim-3 was more accurate as compared with those of
BISAP, APACHE II, and MCTSI score.
• There are two different abbreviations for soluble T-Cell immunoglobulin mucin domain-3 in
the text, sTIM-3 and sTim-3.
Please review this paper.
user
Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 5 Date: 20 Jun 2022
Reviewer's report:
Thank you for your modifications. Although there is a disagreement about the analysis method
still remained, I think it is OK because the ROC curve, sensitivity and specificity for the
prediction of severe AP have been added and well discussed.
Now there are a couple of minor revisions required.
• Please describe the clinical significance about the utility of serum sTim-3 as an indicator of
severity in the early phase of AP not only as an early predictor for SAP in discussion section.
• On line 8 of the discussion section, please delete ‘and more accurate’. The presented data did
not show that predictive value of serum sTim-3 was more accurate as compared with those of
BISAP, APACHE II, and MCTSI score.
• There are two different abbreviations for soluble T-Cell immunoglobulin mucin domain-3 in
the text, sTIM-3 and sTim-3.
assistant