Reviewer's report
Title:Severe cholestatic jaundice after a single administration of ajmaline; a case
report and review of the literature.
Version:7Date:26 February 2014
Reviewer: Guruprasad Aithal
Reviewer's report:
- This case report has a number of important features. 1) Cholestatic jaundice
appeared after a single dose 2) History of drug exposure wasn't available untill
patient had liver biopsy which is an important lesson for clinicians 3) it is not in
the list of drugs in liver tox website which highlights its undereporting.
- Authors have cited a broad non-specific review as a reference for HLA
association with DILI; I suggest that reference 11 is omitted. Instead authors
should cite the original articles highlighting HL associations with cholestatic
jaundice- Lucena MI et al., Gastroenterology. 2011l;141(1):338-47., Donaldson
PT et al., J Hepatol. 2010;53(6):1049-53., and Daly AK et al., Nat Genet.
2009;41(7):816-9.
Reviewer's report
Title:Severe cholestatic jaundice after a single administration of ajmaline; a case
report and review of the literature.
Version:7Date:26 February 2014
Reviewer: Guruprasad Aithal
Reviewer's report:
- This case report has a number of important features. 1) Cholestatic jaundice
appeared after a single dose 2) History of drug exposure wasn't available untill
patient had liver biopsy which is an important lesson for clinicians 3) it is not in
the list of drugs in liver tox website which highlights its undereporting.
- Authors have cited a broad non-specific review as a reference for HLA
association with DILI; I suggest that reference 11 is omitted. Instead authors
should cite the original articles highlighting HL associations with cholestatic
jaundice- Lucena MI et al., Gastroenterology. 2011l;141(1):338-47., Donaldson
PT et al., J Hepatol. 2010;53(6):1049-53., and Daly AK et al., Nat Genet.
2009;41(7):816-9.
Please review this paper.
user
Reviewer's report
Title:Severe cholestatic jaundice after a single administration of ajmaline; a case
report and review of the literature.
Version:7Date:26 February 2014
Reviewer: Guruprasad Aithal
Reviewer's report:
- This case report has a number of important features. 1) Cholestatic jaundice
appeared after a single dose 2) History of drug exposure wasn't available untill
patient had liver biopsy which is an important lesson for clinicians 3) it is not in
the list of drugs in liver tox website which highlights its undereporting.
- Authors have cited a broad non-specific review as a reference for HLA
association with DILI; I suggest that reference 11 is omitted. Instead authors
should cite the original articles highlighting HL associations with cholestatic
jaundice- Lucena MI et al., Gastroenterology. 2011l;141(1):338-47., Donaldson
PT et al., J Hepatol. 2010;53(6):1049-53., and Daly AK et al., Nat Genet.
2009;41(7):816-9.
assistant