Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 3 Date: 05 Mar 2022
Reviewer's report:
The manuscript “Serum soluble T-cell immunoglobulin mucin domain-3 as an early predictive
marker for severity of acute pancreatitis” by Wang et al. is well written and potentially
interesting, however there are several concerns.
Major
• The reviewer could not understand what was being compared in Table 1 and Table 2. What
do the P-values mean? Is SAP compared with MAP + MSAP? If so, a sentence “the length of
hospital stay was longer in patients with MSAP and SAP” on the 3rd-4th lines on page 6 dose
not make sense. Please specify.
• The reviewer could not understand a sentence “the concentration of IL-10 cytokine was not
different significantly among various group” on the 7th-8th lines on page 6 because the P-value
was 0.012 described in Table 2.
• According to Table 2, significant differences (p<0.001) were also shown in white blood cell
count, CRP, Creatinine, and IL-6 not only in sTIM3 and severity scores. Why were they omitted
from subsequent analysis?
• The reviewer could not understand model2 and model3 of multivariable linear regression
analysis. Why were heart rate, respiratory rate, and white blood cell count were adjusted? They
are the factors included in the APACHE II score.
• The reviewer thinks it is necessary to calculate the optimal cutoff value for sTim3 to diagnose
SAP. And the sensitivity and specificity of sTim3 to diagnose SAP should be compared with
those of other markers and severity scores.
Minor
• A sentence “AP or pregnancy induced by trauma” does not make sense on the 6th line on page 4.
• Please specify how many hours taken on admission on average after the onset of AP.
• Please specify when the vital signs listed in Table 1 were measured.
• It is not stated what * means in Figure 1.
• In Figure 1A, the vertical axis is not “SCORE”.
Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 3 Date: 05 Mar 2022
Reviewer's report:
The manuscript “Serum soluble T-cell immunoglobulin mucin domain-3 as an early predictive
marker for severity of acute pancreatitis” by Wang et al. is well written and potentially
interesting, however there are several concerns.
Major
• The reviewer could not understand what was being compared in Table 1 and Table 2. What
do the P-values mean? Is SAP compared with MAP + MSAP? If so, a sentence “the length of
hospital stay was longer in patients with MSAP and SAP” on the 3rd-4th lines on page 6 dose
not make sense. Please specify.
• The reviewer could not understand a sentence “the concentration of IL-10 cytokine was not
different significantly among various group” on the 7th-8th lines on page 6 because the P-value
was 0.012 described in Table 2.
• According to Table 2, significant differences (p<0.001) were also shown in white blood cell
count, CRP, Creatinine, and IL-6 not only in sTIM3 and severity scores. Why were they omitted
from subsequent analysis?
• The reviewer could not understand model2 and model3 of multivariable linear regression
analysis. Why were heart rate, respiratory rate, and white blood cell count were adjusted? They
are the factors included in the APACHE II score.
• The reviewer thinks it is necessary to calculate the optimal cutoff value for sTim3 to diagnose
SAP. And the sensitivity and specificity of sTim3 to diagnose SAP should be compared with
those of other markers and severity scores.
Minor
• A sentence “AP or pregnancy induced by trauma” does not make sense on the 6th line on page 4.
• Please specify how many hours taken on admission on average after the onset of AP.
• Please specify when the vital signs listed in Table 1 were measured.
• It is not stated what * means in Figure 1.
• In Figure 1A, the vertical axis is not “SCORE”.
Please review this paper.
user
Title: Serum Soluble T-Cell Immunoglobulin Mucin Domain-3 as an Early Predictive Marker
for Severity of Acute Pancreatitis This study was a retrospective analysis
Version: 3 Date: 05 Mar 2022
Reviewer's report:
The manuscript “Serum soluble T-cell immunoglobulin mucin domain-3 as an early predictive
marker for severity of acute pancreatitis” by Wang et al. is well written and potentially
interesting, however there are several concerns.
Major
• The reviewer could not understand what was being compared in Table 1 and Table 2. What
do the P-values mean? Is SAP compared with MAP + MSAP? If so, a sentence “the length of
hospital stay was longer in patients with MSAP and SAP” on the 3rd-4th lines on page 6 dose
not make sense. Please specify.
• The reviewer could not understand a sentence “the concentration of IL-10 cytokine was not
different significantly among various group” on the 7th-8th lines on page 6 because the P-value
was 0.012 described in Table 2.
• According to Table 2, significant differences (p<0.001) were also shown in white blood cell
count, CRP, Creatinine, and IL-6 not only in sTIM3 and severity scores. Why were they omitted
from subsequent analysis?
• The reviewer could not understand model2 and model3 of multivariable linear regression
analysis. Why were heart rate, respiratory rate, and white blood cell count were adjusted? They
are the factors included in the APACHE II score.
• The reviewer thinks it is necessary to calculate the optimal cutoff value for sTim3 to diagnose
SAP. And the sensitivity and specificity of sTim3 to diagnose SAP should be compared with
those of other markers and severity scores.
Minor
• A sentence “AP or pregnancy induced by trauma” does not make sense on the 6th line on page 4.
• Please specify how many hours taken on admission on average after the onset of AP.
• Please specify when the vital signs listed in Table 1 were measured.
• It is not stated what * means in Figure 1.
• In Figure 1A, the vertical axis is not “SCORE”.
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