Reviewer's report
Title:Intra-abdominal pressure alterations after large pancreatic pseudocyst
transcutaneous drainage
Version: 1Date:24 November 2008
Reviewer: William Brugge
Reviewer's report:
This is a 9 month prospective, single institution study of 27 patients with a
pancreatic pseudocyst. The authors sought to determine the effect of pseudocyst
drainage on the intra-abdominal pressure (as measured with a urinary bladder
catheter). The patients were divided into two groups: A (CT guided pseudocyst
drainage) and B (no drainage). The authors found that pseudocyst drainage was
associated with a decrease, but transient, in intra-abdominal pressure.
Comments to the authors
1. The authors should comment on the location of the pseudocysts and whether
the retroperitoneal location will effect intra-abdominal pressure
2. It would have been interesting to know the rate of reaccumulation of the
pseudocyst after drainage. Perhaps the rise in the IAP after drainage was a
result of reaccmulation of pseudocyst fluid.
3. How were the patients assigned to the groups?
4. The clinical significance in the elevated IAP is not clear
5. Please provide the characteristics of the pseudocyst fluid (protein
concentration, WBC count, amylase, and CEA)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
Consultant, Boston Scientific
Reviewer's report
Title:Intra-abdominal pressure alterations after large pancreatic pseudocyst
transcutaneous drainage
Version: 1Date:24 November 2008
Reviewer: William Brugge
Reviewer's report:
This is a 9 month prospective, single institution study of 27 patients with a
pancreatic pseudocyst. The authors sought to determine the effect of pseudocyst
drainage on the intra-abdominal pressure (as measured with a urinary bladder
catheter). The patients were divided into two groups: A (CT guided pseudocyst
drainage) and B (no drainage). The authors found that pseudocyst drainage was
associated with a decrease, but transient, in intra-abdominal pressure.
Comments to the authors
1. The authors should comment on the location of the pseudocysts and whether
the retroperitoneal location will effect intra-abdominal pressure
2. It would have been interesting to know the rate of reaccumulation of the
pseudocyst after drainage. Perhaps the rise in the IAP after drainage was a
result of reaccmulation of pseudocyst fluid.
3. How were the patients assigned to the groups?
4. The clinical significance in the elevated IAP is not clear
5. Please provide the characteristics of the pseudocyst fluid (protein
concentration, WBC count, amylase, and CEA)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
Consultant, Boston Scientific
Please review this paper.
user
Reviewer's report
Title:Intra-abdominal pressure alterations after large pancreatic pseudocyst
transcutaneous drainage
Version: 1Date:24 November 2008
Reviewer: William Brugge
Reviewer's report:
This is a 9 month prospective, single institution study of 27 patients with a
pancreatic pseudocyst. The authors sought to determine the effect of pseudocyst
drainage on the intra-abdominal pressure (as measured with a urinary bladder
catheter). The patients were divided into two groups: A (CT guided pseudocyst
drainage) and B (no drainage). The authors found that pseudocyst drainage was
associated with a decrease, but transient, in intra-abdominal pressure.
Comments to the authors
1. The authors should comment on the location of the pseudocysts and whether
the retroperitoneal location will effect intra-abdominal pressure
2. It would have been interesting to know the rate of reaccumulation of the
pseudocyst after drainage. Perhaps the rise in the IAP after drainage was a
result of reaccmulation of pseudocyst fluid.
3. How were the patients assigned to the groups?
4. The clinical significance in the elevated IAP is not clear
5. Please provide the characteristics of the pseudocyst fluid (protein
concentration, WBC count, amylase, and CEA)
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
Consultant, Boston Scientific
assistant