Reviewer's report
Title:Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia,
phosphorylation of NMDA receptors, and cytokines expression in the thoracic
spinal dorsal horn
Version: 1Date:17 May 2012
Reviewer: Nian-Song NSQ Qian
Reviewer's report:
Minor Essential Revisions
In this study, Feng et al observed that intrathecal injection of Resolvin D1 could
dose-dependently attenuate pain of CP. They also showed that intrathecal
injection of RvD could remarkably reverse NMDA receptor phosphorylation and
cytokine expressions in the spinal dorsal horn of CP rats. The present study is a
These findings are interesting and important and may provide new insights into
mechanism and treatment of pain in patients of chronic pancreatitis. The
methods are appropriately described, the experiments are well designed, and the
data is sound and convincing. The discussion and conclusions are well balanced
and adequately supported by the data. However, there are a few errors in
grammar and spelling that need to be corrected. Figure 3 and 4 Legends: Please
provide more explanatory information in the legend.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia,
phosphorylation of NMDA receptors, and cytokines expression in the thoracic
spinal dorsal horn
Version: 1Date:17 May 2012
Reviewer: Nian-Song NSQ Qian
Reviewer's report:
Minor Essential Revisions
In this study, Feng et al observed that intrathecal injection of Resolvin D1 could
dose-dependently attenuate pain of CP. They also showed that intrathecal
injection of RvD could remarkably reverse NMDA receptor phosphorylation and
cytokine expressions in the spinal dorsal horn of CP rats. The present study is a
These findings are interesting and important and may provide new insights into
mechanism and treatment of pain in patients of chronic pancreatitis. The
methods are appropriately described, the experiments are well designed, and the
data is sound and convincing. The discussion and conclusions are well balanced
and adequately supported by the data. However, there are a few errors in
grammar and spelling that need to be corrected. Figure 3 and 4 Legends: Please
provide more explanatory information in the legend.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Resolvin D1 reverses chronic pancreatitis-induced mechanical allodynia,
phosphorylation of NMDA receptors, and cytokines expression in the thoracic
spinal dorsal horn
Version: 1Date:17 May 2012
Reviewer: Nian-Song NSQ Qian
Reviewer's report:
Minor Essential Revisions
In this study, Feng et al observed that intrathecal injection of Resolvin D1 could
dose-dependently attenuate pain of CP. They also showed that intrathecal
injection of RvD could remarkably reverse NMDA receptor phosphorylation and
cytokine expressions in the spinal dorsal horn of CP rats. The present study is a
These findings are interesting and important and may provide new insights into
mechanism and treatment of pain in patients of chronic pancreatitis. The
methods are appropriately described, the experiments are well designed, and the
data is sound and convincing. The discussion and conclusions are well balanced
and adequately supported by the data. However, there are a few errors in
grammar and spelling that need to be corrected. Figure 3 and 4 Legends: Please
provide more explanatory information in the legend.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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