Title: Identification of the angiogenesis related genes for predicting prognosis of patients with
gastric cancer
Version: 1 Date: 28 Dec 2020
Reviewer's report:
1#This is an article of pure bioinformatics analysis. A common problem of this type of article
is that different database processing results may be inconsistent and lack of validation of actual
samples.So the best thing to do is, can the author provide clinical validation data for his actual
sample?
2# The results showed that AGT, ANGPT1, SERPINE1, ANGPT2, PROCR, KIT, PLAUR and
CAV1 were strongly positive in GC tissues compared to normal gastric tissues in figure 8.
Whereas the SERPINE1 also see stornge expression in normal tissue. The same problem is that
some other markers expression were found in tumor stromal cells, most of which were poorly
differentiated diffuse tumor tissues, and the expression was not significantly increased in tumor
cells.
3#A positive comparison of other tumor angiogenesis related factors, such as VEGF, is
recommended.
Title: Identification of the angiogenesis related genes for predicting prognosis of patients with
gastric cancer
Version: 1 Date: 28 Dec 2020
Reviewer's report:
1#This is an article of pure bioinformatics analysis. A common problem of this type of article
is that different database processing results may be inconsistent and lack of validation of actual
samples.So the best thing to do is, can the author provide clinical validation data for his actual
sample?
2# The results showed that AGT, ANGPT1, SERPINE1, ANGPT2, PROCR, KIT, PLAUR and
CAV1 were strongly positive in GC tissues compared to normal gastric tissues in figure 8.
Whereas the SERPINE1 also see stornge expression in normal tissue. The same problem is that
some other markers expression were found in tumor stromal cells, most of which were poorly
differentiated diffuse tumor tissues, and the expression was not significantly increased in tumor
cells.
3#A positive comparison of other tumor angiogenesis related factors, such as VEGF, is
recommended.
Please review this paper.
user
Title: Identification of the angiogenesis related genes for predicting prognosis of patients with
gastric cancer
Version: 1 Date: 28 Dec 2020
Reviewer's report:
1#This is an article of pure bioinformatics analysis. A common problem of this type of article
is that different database processing results may be inconsistent and lack of validation of actual
samples.So the best thing to do is, can the author provide clinical validation data for his actual
sample?
2# The results showed that AGT, ANGPT1, SERPINE1, ANGPT2, PROCR, KIT, PLAUR and
CAV1 were strongly positive in GC tissues compared to normal gastric tissues in figure 8.
Whereas the SERPINE1 also see stornge expression in normal tissue. The same problem is that
some other markers expression were found in tumor stromal cells, most of which were poorly
differentiated diffuse tumor tissues, and the expression was not significantly increased in tumor
cells.
3#A positive comparison of other tumor angiogenesis related factors, such as VEGF, is
recommended.
assistant