Reviewer's report
Title:The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux
Disease
Version: 3Date:29 September 2009
Reviewer: Stanis&#322;aw Konturek
Reviewer's report:
Major Compulsory Revisions:
The data enclosed suggest that melatonin could inhibit gastric acid secretion in
humans with GERD but no secretory data have been included. Furthermore, the
drop of pH could result in the rise in gastrin release due to reduction in antral
autoregulation of gastric acid secretion and the rise of gastrin release. Again
plasma gastrin level was not measured in this report. Most important it is not
clear from this study whether functional improvement in GERD was also
accompanied by the adequate changes in histology of esophageal mucosa. I
would request the addition of the histological data of esophageal mucosa in
patients with GERD before and after treatment with melatonin.
Minor Essential Revisions:
Melatonin is a potent antioxidant acting, at least in part, via COX-prostaglandin
and NOS-nitic oxide systems (ref 27), that should be measured in esophageal
mucosa before and after melatonin therapy to determine the mechanism of
antiinflammatory action of this indole.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests' below. If your reply is yes to any,
please give details below.
Reviewer's report
Title:The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux
Disease
Version: 3Date:29 September 2009
Reviewer: Stanis&#322;aw Konturek
Reviewer's report:
Major Compulsory Revisions:
The data enclosed suggest that melatonin could inhibit gastric acid secretion in
humans with GERD but no secretory data have been included. Furthermore, the
drop of pH could result in the rise in gastrin release due to reduction in antral
autoregulation of gastric acid secretion and the rise of gastrin release. Again
plasma gastrin level was not measured in this report. Most important it is not
clear from this study whether functional improvement in GERD was also
accompanied by the adequate changes in histology of esophageal mucosa. I
would request the addition of the histological data of esophageal mucosa in
patients with GERD before and after treatment with melatonin.
Minor Essential Revisions:
Melatonin is a potent antioxidant acting, at least in part, via COX-prostaglandin
and NOS-nitic oxide systems (ref 27), that should be measured in esophageal
mucosa before and after melatonin therapy to determine the mechanism of
antiinflammatory action of this indole.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests' below. If your reply is yes to any,
please give details below.
Please review this paper.
user
Reviewer's report
Title:The Potential Therapeutic Effect of Melatonin in Gastro-esophageal Reflux
Disease
Version: 3Date:29 September 2009
Reviewer: Stanis&#322;aw Konturek
Reviewer's report:
Major Compulsory Revisions:
The data enclosed suggest that melatonin could inhibit gastric acid secretion in
humans with GERD but no secretory data have been included. Furthermore, the
drop of pH could result in the rise in gastrin release due to reduction in antral
autoregulation of gastric acid secretion and the rise of gastrin release. Again
plasma gastrin level was not measured in this report. Most important it is not
clear from this study whether functional improvement in GERD was also
accompanied by the adequate changes in histology of esophageal mucosa. I
would request the addition of the histological data of esophageal mucosa in
patients with GERD before and after treatment with melatonin.
Minor Essential Revisions:
Melatonin is a potent antioxidant acting, at least in part, via COX-prostaglandin
and NOS-nitic oxide systems (ref 27), that should be measured in esophageal
mucosa before and after melatonin therapy to determine the mechanism of
antiinflammatory action of this indole.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests' below. If your reply is yes to any,
please give details below.
assistant