Title: The effect of propranolol on gastrointestinal motility and permeability in patients with
cirrhosis and significant portal hypertension
Version: 3 Date: 21 Aug 2024
Reviewer's report:
Thank you for addressing the issues raised.
With regards to the issue raised on specific cut-off for increase or decrease in OCTT, IP,
inflammatory markers and BT, the authors clarified that no cut-off was used and all patients had
more than 10% change in pre- and post-NSBB values. It then be very helpful for the authors
to state under Methods that no cut-off was used to define increase or decrease. It would also
help the readers of this manuscript if the authors could add range of percentage change in the
pre- and post-NSBB values. That way, the readers can see for themselves the value change was
significant.
Title: The effect of propranolol on gastrointestinal motility and permeability in patients with
cirrhosis and significant portal hypertension
Version: 3 Date: 21 Aug 2024
Reviewer's report:
Thank you for addressing the issues raised.
With regards to the issue raised on specific cut-off for increase or decrease in OCTT, IP,
inflammatory markers and BT, the authors clarified that no cut-off was used and all patients had
more than 10% change in pre- and post-NSBB values. It then be very helpful for the authors
to state under Methods that no cut-off was used to define increase or decrease. It would also
help the readers of this manuscript if the authors could add range of percentage change in the
pre- and post-NSBB values. That way, the readers can see for themselves the value change was
significant.
Please review this paper.
user
Title: The effect of propranolol on gastrointestinal motility and permeability in patients with
cirrhosis and significant portal hypertension
Version: 3 Date: 21 Aug 2024
Reviewer's report:
Thank you for addressing the issues raised.
With regards to the issue raised on specific cut-off for increase or decrease in OCTT, IP,
inflammatory markers and BT, the authors clarified that no cut-off was used and all patients had
more than 10% change in pre- and post-NSBB values. It then be very helpful for the authors
to state under Methods that no cut-off was used to define increase or decrease. It would also
help the readers of this manuscript if the authors could add range of percentage change in the
pre- and post-NSBB values. That way, the readers can see for themselves the value change was
significant.
assistant