Title: Analysis of risk factors related to acute exacerbation in patients with chronic pancreatitis:
a retrospective study of 313 cases from a single center in China
Version: 3 Date: 19 Sep 2024
Reviewer:  Sushila Kumar Pattanaik
Reviewer's report:
Very good concept. It will add to the limited literature on this controversial topic. Under authors'
contribution, meaning of the last sentence is not clear. And, please look into publication ethics
as per  ICMJE and author guidelines of the journal, if funding only can satisfy the criteria of
authorship. If yes, I like to give you few suggestions to revise the manuscript.
1. Reference No 3 may be rewritten in Vancouver style. 2023;23(2):143-150.
2. In Table 1, the p-value is 0.000 under age and abdominal pain. No much difference, but you
can go beyond 3 decimal points if you achieve it.. Please correct the spelling 'Diabetes'.
3. In Table 2 and in text, CA 19-9 instead of CA 199 may be better appreciated.
4. Under Patient selection: 'Asia Pacific consensus diagnosed all patients'  may be changed to
'All patients were diagnosed as CP as per Asia Pacific consensus'. I think, you mean that.
Why you excluded suspected cases of groove pancreatitis before confirmation. ACP may have
similar symptoms as you mentioned.
6. Under Statistics:  'risk factors involving the 11 indices above', but the 11 indices have not
been mentioned above.
7. Under Discussion para 1: -Diagnosis was established through 'physical examination' or
'investigation' to get the pancreatic calcification, please rectify.
-163 ACP out of 313 CP- Incidence is higher than earlier literature. please explain why.
-less pancreatic fibrosis in younger individuals with lower age- 'with lower age' may be omitted.
8. Under Discussion para 3: 35% shows history of RAP, but percentage is not shown in table
or in result section. You can write 110 out of 313 (35%) here.
9. Under Discussion para 4: 'With the continuous.....late stage of the disease; pancreatic
atrophy, fibrosis is serious;.......acute inflammation.'- Please break the sentence or use correct
punctuations.
10. Under Discussion para 7: 'In the study of risk factors' may be replaced by 'In this study of
risk factors' .
Title: Analysis of risk factors related to acute exacerbation in patients with chronic pancreatitis:
a retrospective study of 313 cases from a single center in China
Version: 3 Date: 19 Sep 2024
Reviewer:  Sushila Kumar Pattanaik
Reviewer's report:
Very good concept. It will add to the limited literature on this controversial topic. Under authors'
contribution, meaning of the last sentence is not clear. And, please look into publication ethics
as per  ICMJE and author guidelines of the journal, if funding only can satisfy the criteria of
authorship. If yes, I like to give you few suggestions to revise the manuscript.
1. Reference No 3 may be rewritten in Vancouver style. 2023;23(2):143-150.
2. In Table 1, the p-value is 0.000 under age and abdominal pain. No much difference, but you
can go beyond 3 decimal points if you achieve it.. Please correct the spelling 'Diabetes'.
3. In Table 2 and in text, CA 19-9 instead of CA 199 may be better appreciated.
4. Under Patient selection: 'Asia Pacific consensus diagnosed all patients'  may be changed to
'All patients were diagnosed as CP as per Asia Pacific consensus'. I think, you mean that.
Why you excluded suspected cases of groove pancreatitis before confirmation. ACP may have
similar symptoms as you mentioned.
6. Under Statistics:  'risk factors involving the 11 indices above', but the 11 indices have not
been mentioned above.
7. Under Discussion para 1: -Diagnosis was established through 'physical examination' or
'investigation' to get the pancreatic calcification, please rectify.
-163 ACP out of 313 CP- Incidence is higher than earlier literature. please explain why.
-less pancreatic fibrosis in younger individuals with lower age- 'with lower age' may be omitted.
8. Under Discussion para 3: 35% shows history of RAP, but percentage is not shown in table
or in result section. You can write 110 out of 313 (35%) here.
9. Under Discussion para 4: 'With the continuous.....late stage of the disease; pancreatic
atrophy, fibrosis is serious;.......acute inflammation.'- Please break the sentence or use correct
punctuations.
10. Under Discussion para 7: 'In the study of risk factors' may be replaced by 'In this study of
risk factors' .
Please review this paper.
user
Title: Analysis of risk factors related to acute exacerbation in patients with chronic pancreatitis:
a retrospective study of 313 cases from a single center in China
Version: 3 Date: 19 Sep 2024
Reviewer:  Sushila Kumar Pattanaik
Reviewer's report:
Very good concept. It will add to the limited literature on this controversial topic. Under authors'
contribution, meaning of the last sentence is not clear. And, please look into publication ethics
as per  ICMJE and author guidelines of the journal, if funding only can satisfy the criteria of
authorship. If yes, I like to give you few suggestions to revise the manuscript.
1. Reference No 3 may be rewritten in Vancouver style. 2023;23(2):143-150.
2. In Table 1, the p-value is 0.000 under age and abdominal pain. No much difference, but you
can go beyond 3 decimal points if you achieve it.. Please correct the spelling 'Diabetes'.
3. In Table 2 and in text, CA 19-9 instead of CA 199 may be better appreciated.
4. Under Patient selection: 'Asia Pacific consensus diagnosed all patients'  may be changed to
'All patients were diagnosed as CP as per Asia Pacific consensus'. I think, you mean that.
Why you excluded suspected cases of groove pancreatitis before confirmation. ACP may have
similar symptoms as you mentioned.
6. Under Statistics:  'risk factors involving the 11 indices above', but the 11 indices have not
been mentioned above.
7. Under Discussion para 1: -Diagnosis was established through 'physical examination' or
'investigation' to get the pancreatic calcification, please rectify.
-163 ACP out of 313 CP- Incidence is higher than earlier literature. please explain why.
-less pancreatic fibrosis in younger individuals with lower age- 'with lower age' may be omitted.
8. Under Discussion para 3: 35% shows history of RAP, but percentage is not shown in table
or in result section. You can write 110 out of 313 (35%) here.
9. Under Discussion para 4: 'With the continuous.....late stage of the disease; pancreatic
atrophy, fibrosis is serious;.......acute inflammation.'- Please break the sentence or use correct
punctuations.
10. Under Discussion para 7: 'In the study of risk factors' may be replaced by 'In this study of
risk factors' .
assistant