Title: Diagnostic Performance of Procalcitonin for Bacterial Infection in Severe Alcoholic
Hepatitis Compared with C-Reactive Protein
Version: 1 Date: 17 Aug 2024
Reviewer's report:
This is a very nice manusript of a very-well done study on an important subject.
I congratulate the authors of this very fine piece of work!
I have got only minor remarks
Minor remarks
- for at not very attentive reader who is a liver expert, it may be unclear how severe alcoholic
hepatitis was definded. Perhaps the authors could repeat this fact in the introduction / discussion
section
- I am confused why cholecystitis was among the causes of sepsis, but not of bacterial infection
- last part of the result section: the authors might clarify by giving the patient number that the last
calculation of sepsis among SIRS patients is a sub-analysis, which otherwise may be confusing
- Sensitivity, specificity and so on are very important, the authors give these data only in the
tables. I would advise mentioning the key data either in the text or indicating directly that this
information is given in the tables
- it is unclear, where the numbers of specificity and NPV of 84.4 and 85.5% come from in the
discussion section
- the neutrophil to lymphocyte ratio (PMID: 31313853 DOI: 10.1111/apt.15335) has been
implicated in severity of alcoholic hepatitis and indirectly to the risk for bacterial infection. Can
we authors present data on neutrophils and lymphocytes in their patients?
Title: Diagnostic Performance of Procalcitonin for Bacterial Infection in Severe Alcoholic
Hepatitis Compared with C-Reactive Protein
Version: 1 Date: 17 Aug 2024
Reviewer's report:
This is a very nice manusript of a very-well done study on an important subject.
I congratulate the authors of this very fine piece of work!
I have got only minor remarks
Minor remarks
- for at not very attentive reader who is a liver expert, it may be unclear how severe alcoholic
hepatitis was definded. Perhaps the authors could repeat this fact in the introduction / discussion
section
- I am confused why cholecystitis was among the causes of sepsis, but not of bacterial infection
- last part of the result section: the authors might clarify by giving the patient number that the last
calculation of sepsis among SIRS patients is a sub-analysis, which otherwise may be confusing
- Sensitivity, specificity and so on are very important, the authors give these data only in the
tables. I would advise mentioning the key data either in the text or indicating directly that this
information is given in the tables
- it is unclear, where the numbers of specificity and NPV of 84.4 and 85.5% come from in the
discussion section
- the neutrophil to lymphocyte ratio (PMID: 31313853 DOI: 10.1111/apt.15335) has been
implicated in severity of alcoholic hepatitis and indirectly to the risk for bacterial infection. Can
we authors present data on neutrophils and lymphocytes in their patients?
Please review this paper.
user
Title: Diagnostic Performance of Procalcitonin for Bacterial Infection in Severe Alcoholic
Hepatitis Compared with C-Reactive Protein
Version: 1 Date: 17 Aug 2024
Reviewer's report:
This is a very nice manusript of a very-well done study on an important subject.
I congratulate the authors of this very fine piece of work!
I have got only minor remarks
Minor remarks
- for at not very attentive reader who is a liver expert, it may be unclear how severe alcoholic
hepatitis was definded. Perhaps the authors could repeat this fact in the introduction / discussion
section
- I am confused why cholecystitis was among the causes of sepsis, but not of bacterial infection
- last part of the result section: the authors might clarify by giving the patient number that the last
calculation of sepsis among SIRS patients is a sub-analysis, which otherwise may be confusing
- Sensitivity, specificity and so on are very important, the authors give these data only in the
tables. I would advise mentioning the key data either in the text or indicating directly that this
information is given in the tables
- it is unclear, where the numbers of specificity and NPV of 84.4 and 85.5% come from in the
discussion section
- the neutrophil to lymphocyte ratio (PMID: 31313853 DOI: 10.1111/apt.15335) has been
implicated in severity of alcoholic hepatitis and indirectly to the risk for bacterial infection. Can
we authors present data on neutrophils and lymphocytes in their patients?
assistant