Title: Association between circadian syndrome and gallstones: a cross-sectional study of
NHANES 2017–2020
Version: 5 Date: 30 Oct 2024
Reviewer's report:
The article investigates the association between circadian syndrome (CircS) and gallstones using
data from the NHANES during a four years period. The study suggests a positive correlation,
indicating that CircS may increase the risk of gallstone development. The research employs
robust statistical methods.
The article addresses a previously unexplored subject which is the relationship between CircS
and gallstones,
The study’s cross-sectional nature limits causal inferences. It is unclear in the study whether
CircS directly contributes to gallstone formation or vice versa.
Self-reported diagnoses of gallstones is a bias in the prevalence estimation
The discussion effectively contextualizes the findings within existing literature on circadian
rhythms. The authors appropriately speculate on the biological mechanisms linking CircS to
gallstone formation, such as disruptions in metabolism and the role of gut microbiota.
Overall, the article presents significant findings. Future research could benefit from a
longitudinal approach to establish causality. between CircS and gallstone development.
Expanding research to include diverse populations could help validate findings across different
demographic groups.
This article makes a valuable contribution to the literature on circadian health, presenting a fresh
perspective on gallstone risk factors and emphasizing the significance of circadian rhythms in
managing chronic diseases.
Title: Association between circadian syndrome and gallstones: a cross-sectional study of
NHANES 2017–2020
Version: 5 Date: 30 Oct 2024
Reviewer's report:
The article investigates the association between circadian syndrome (CircS) and gallstones using
data from the NHANES during a four years period. The study suggests a positive correlation,
indicating that CircS may increase the risk of gallstone development. The research employs
robust statistical methods.
The article addresses a previously unexplored subject which is the relationship between CircS
and gallstones,
The study’s cross-sectional nature limits causal inferences. It is unclear in the study whether
CircS directly contributes to gallstone formation or vice versa.
Self-reported diagnoses of gallstones is a bias in the prevalence estimation
The discussion effectively contextualizes the findings within existing literature on circadian
rhythms. The authors appropriately speculate on the biological mechanisms linking CircS to
gallstone formation, such as disruptions in metabolism and the role of gut microbiota.
Overall, the article presents significant findings. Future research could benefit from a
longitudinal approach to establish causality. between CircS and gallstone development.
Expanding research to include diverse populations could help validate findings across different
demographic groups.
This article makes a valuable contribution to the literature on circadian health, presenting a fresh
perspective on gallstone risk factors and emphasizing the significance of circadian rhythms in
managing chronic diseases.
Please review this paper.
user
Title: Association between circadian syndrome and gallstones: a cross-sectional study of
NHANES 2017–2020
Version: 5 Date: 30 Oct 2024
Reviewer's report:
The article investigates the association between circadian syndrome (CircS) and gallstones using
data from the NHANES during a four years period. The study suggests a positive correlation,
indicating that CircS may increase the risk of gallstone development. The research employs
robust statistical methods.
The article addresses a previously unexplored subject which is the relationship between CircS
and gallstones,
The study’s cross-sectional nature limits causal inferences. It is unclear in the study whether
CircS directly contributes to gallstone formation or vice versa.
Self-reported diagnoses of gallstones is a bias in the prevalence estimation
The discussion effectively contextualizes the findings within existing literature on circadian
rhythms. The authors appropriately speculate on the biological mechanisms linking CircS to
gallstone formation, such as disruptions in metabolism and the role of gut microbiota.
Overall, the article presents significant findings. Future research could benefit from a
longitudinal approach to establish causality. between CircS and gallstone development.
Expanding research to include diverse populations could help validate findings across different
demographic groups.
This article makes a valuable contribution to the literature on circadian health, presenting a fresh
perspective on gallstone risk factors and emphasizing the significance of circadian rhythms in
managing chronic diseases.
assistant