Title: Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition
criteria in nutritional diagnosis of hepatocellular carcinoma
Version: 3 Date: 11 Aug 2024
Reviewer's report:
The authors present an interesting, though not novel, manuscript. They showed that patients
with HCC and concomitant malnutrion have a higher mortality rate than HCC patients without
malnutrition. The article is well written, however I have a few suggestions.
1. A control group of cirrhotic patients with no HCC should be added, otherwise this should be
added to limitations section
2. The fact that HCC per se leads to malnutriotion due to inflammation should be added in
causes of malnutrition due to HCC (ref: doi: 10.1002/hep.30036; doi: 10.3390/ijms23169430;
doi: 10.1038/s41590-018-0044-z)
Title: Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition
criteria in nutritional diagnosis of hepatocellular carcinoma
Version: 3 Date: 11 Aug 2024
Reviewer's report:
The authors present an interesting, though not novel, manuscript. They showed that patients
with HCC and concomitant malnutrion have a higher mortality rate than HCC patients without
malnutrition. The article is well written, however I have a few suggestions.
1. A control group of cirrhotic patients with no HCC should be added, otherwise this should be
added to limitations section
2. The fact that HCC per se leads to malnutriotion due to inflammation should be added in
causes of malnutrition due to HCC (ref: doi: 10.1002/hep.30036; doi: 10.3390/ijms23169430;
doi: 10.1038/s41590-018-0044-z)
Please review this paper.
user
Title: Reduced muscle mass is an important part of Global Leadership Initiative on Malnutrition
criteria in nutritional diagnosis of hepatocellular carcinoma
Version: 3 Date: 11 Aug 2024
Reviewer's report:
The authors present an interesting, though not novel, manuscript. They showed that patients
with HCC and concomitant malnutrion have a higher mortality rate than HCC patients without
malnutrition. The article is well written, however I have a few suggestions.
1. A control group of cirrhotic patients with no HCC should be added, otherwise this should be
added to limitations section
2. The fact that HCC per se leads to malnutriotion due to inflammation should be added in
causes of malnutrition due to HCC (ref: doi: 10.1002/hep.30036; doi: 10.3390/ijms23169430;
doi: 10.1038/s41590-018-0044-z)
assistant