Title: Development and validation of the nomogram based on INR and eGFR for estimation of
mortality in patients with acute-on-chronic hepatitis B liver failure
Version: 0 Date: 22 Jul 2021
Reviewer's report:
As the authors described, reactivation of hepatitis B virus is the most leading cause of ACLF
in Asian-Pacific region, and clinical characteristics of ACHBLF are not alike other causes of
liver failure.
Unfortunately, in the estimation of mortality in patients with hepatitis B related acute-on-chronic
liver failure, the authors did not include important and well-known variables such as HBV-DNA.
Title: Development and validation of the nomogram based on INR and eGFR for estimation of
mortality in patients with acute-on-chronic hepatitis B liver failure
Version: 0 Date: 22 Jul 2021
Reviewer's report:
As the authors described, reactivation of hepatitis B virus is the most leading cause of ACLF
in Asian-Pacific region, and clinical characteristics of ACHBLF are not alike other causes of
liver failure.
Unfortunately, in the estimation of mortality in patients with hepatitis B related acute-on-chronic
liver failure, the authors did not include important and well-known variables such as HBV-DNA.
Please review this paper.
user
Title: Development and validation of the nomogram based on INR and eGFR for estimation of
mortality in patients with acute-on-chronic hepatitis B liver failure
Version: 0 Date: 22 Jul 2021
Reviewer's report:
As the authors described, reactivation of hepatitis B virus is the most leading cause of ACLF
in Asian-Pacific region, and clinical characteristics of ACHBLF are not alike other causes of
liver failure.
Unfortunately, in the estimation of mortality in patients with hepatitis B related acute-on-chronic
liver failure, the authors did not include important and well-known variables such as HBV-DNA.
assistant