Reviewer's report
Title:Involvement of a periodontal pathogen, Porphyromonas gingivalis on the
pathogenesis of non-alcoholic fatty liver disease.
Version: 2Date:19 September 2011
Reviewer: Lawrence J Saubermann
Reviewer's report:
Major Compulsory Revisions:
1. In Figure 4, was there a change in weight or other medical treatments in the 10
subjects with NAFLD?
2. In Table 3, the ALT and gGTP levels were higher in the P. gingivalis (-) group.
Although these were not significantly different than the PG (+) group, it raises
concern with the hypothesis the authors are proposing. How do they explain this?
3. The authors mention that other oral bacteria did not affect the HFD NAFLD
mouse model (data not shown). It would strengthen their paper if they did include
the data.
Minor essential revisions:
1. The discussion mentions the same statement twice. At the top of page 20, the
sentence is almost the same as the one at the bottom of the page and top of
page 21. It discusses how PG may be involved in both the first and second
stages of NAFL.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Involvement of a periodontal pathogen, Porphyromonas gingivalis on the
pathogenesis of non-alcoholic fatty liver disease.
Version: 2Date:19 September 2011
Reviewer: Lawrence J Saubermann
Reviewer's report:
Major Compulsory Revisions:
1. In Figure 4, was there a change in weight or other medical treatments in the 10
subjects with NAFLD?
2. In Table 3, the ALT and gGTP levels were higher in the P. gingivalis (-) group.
Although these were not significantly different than the PG (+) group, it raises
concern with the hypothesis the authors are proposing. How do they explain this?
3. The authors mention that other oral bacteria did not affect the HFD NAFLD
mouse model (data not shown). It would strengthen their paper if they did include
the data.
Minor essential revisions:
1. The discussion mentions the same statement twice. At the top of page 20, the
sentence is almost the same as the one at the bottom of the page and top of
page 21. It discusses how PG may be involved in both the first and second
stages of NAFL.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Involvement of a periodontal pathogen, Porphyromonas gingivalis on the
pathogenesis of non-alcoholic fatty liver disease.
Version: 2Date:19 September 2011
Reviewer: Lawrence J Saubermann
Reviewer's report:
Major Compulsory Revisions:
1. In Figure 4, was there a change in weight or other medical treatments in the 10
subjects with NAFLD?
2. In Table 3, the ALT and gGTP levels were higher in the P. gingivalis (-) group.
Although these were not significantly different than the PG (+) group, it raises
concern with the hypothesis the authors are proposing. How do they explain this?
3. The authors mention that other oral bacteria did not affect the HFD NAFLD
mouse model (data not shown). It would strengthen their paper if they did include
the data.
Minor essential revisions:
1. The discussion mentions the same statement twice. At the top of page 20, the
sentence is almost the same as the one at the bottom of the page and top of
page 21. It discusses how PG may be involved in both the first and second
stages of NAFL.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant