Title: Effectiveness of a Thrombin-gelatin Flowable for treating severe liver bleeding: An
experimental study
Version: 2 Date: 07 Nov 2023
Reviewer's report:
In this submission Dr. Sanchez del Valle and co-authors present data comparing the effectiveness
of a flowable hemostat with that of standard wound packing in a novel hepatic vein injury model.
The submission could be improved by the following:
1. The method of randomization for the treatment methods should be described in more detail
with respect to if it was after the wounds were created as well as the days on which the animals
underwent the procedure and the specific surgeons doing each animal.
2. Clarify why was 12 minutes of pressure applied to the wounds in the flowable group and not
in the packing group. Does the instructions for use of the flowable recommend 12 minutes of
pressure application?
3. Should the pressure time be added to the application time for the flowable?
4. Explain how was blood collected for measurement of weight of blood lost.
5. Use of capitals in titles and body of paper could be standardized.
6. The primary endpoint results of the study could be presented in tabular form.
7. The assignment of Level of Evidence I could be explained as this level is often reserved only
for randomized controlled studies.
8. Why were the methods of determining blood loss in the first 12 minutes in the two groups
different?
Title: Effectiveness of a Thrombin-gelatin Flowable for treating severe liver bleeding: An
experimental study
Version: 2 Date: 07 Nov 2023
Reviewer's report:
In this submission Dr. Sanchez del Valle and co-authors present data comparing the effectiveness
of a flowable hemostat with that of standard wound packing in a novel hepatic vein injury model.
The submission could be improved by the following:
1. The method of randomization for the treatment methods should be described in more detail
with respect to if it was after the wounds were created as well as the days on which the animals
underwent the procedure and the specific surgeons doing each animal.
2. Clarify why was 12 minutes of pressure applied to the wounds in the flowable group and not
in the packing group. Does the instructions for use of the flowable recommend 12 minutes of
pressure application?
3. Should the pressure time be added to the application time for the flowable?
4. Explain how was blood collected for measurement of weight of blood lost.
5. Use of capitals in titles and body of paper could be standardized.
6. The primary endpoint results of the study could be presented in tabular form.
7. The assignment of Level of Evidence I could be explained as this level is often reserved only
for randomized controlled studies.
8. Why were the methods of determining blood loss in the first 12 minutes in the two groups
different?
Please review this paper.
user
Title: Effectiveness of a Thrombin-gelatin Flowable for treating severe liver bleeding: An
experimental study
Version: 2 Date: 07 Nov 2023
Reviewer's report:
In this submission Dr. Sanchez del Valle and co-authors present data comparing the effectiveness
of a flowable hemostat with that of standard wound packing in a novel hepatic vein injury model.
The submission could be improved by the following:
1. The method of randomization for the treatment methods should be described in more detail
with respect to if it was after the wounds were created as well as the days on which the animals
underwent the procedure and the specific surgeons doing each animal.
2. Clarify why was 12 minutes of pressure applied to the wounds in the flowable group and not
in the packing group. Does the instructions for use of the flowable recommend 12 minutes of
pressure application?
3. Should the pressure time be added to the application time for the flowable?
4. Explain how was blood collected for measurement of weight of blood lost.
5. Use of capitals in titles and body of paper could be standardized.
6. The primary endpoint results of the study could be presented in tabular form.
7. The assignment of Level of Evidence I could be explained as this level is often reserved only
for randomized controlled studies.
8. Why were the methods of determining blood loss in the first 12 minutes in the two groups
different?
assistant