Title: Effect of Synbiotics on the Cardiovascular Risk Factors in Patients with Non- alcoholic
Fatty Liver: A GRADE Evidence Systematic Review, Meta-analysis
Version: 0 Date: 31 Jan 2025
Reviewer's report:
This manuscript addresses an important topic regarding the effectiveness and safety of dietary
supplements in managing uric acid levels. Below are my comments and suggestions for
improvement:
General Comments
The manuscript presents a timely and relevant investigation into dietary supplements, given the
increasing prevalence of hyperuricemia and its associated health issues.
The research question is clearly defined, and the study aims are well-articulated.
Strengths
Comprehensive Review: The manuscript provides a thorough review of existing literature,
which helps contextualize the study within the broader field of dietary interventions for uric
acid management.
Methodological Rigor: The use of appropriate statistical methods for analysis adds credibility to
the findings. The network meta-analysis approach is particularly suitable for comparing multiple
interventions.
Areas for Improvement
Clarity in Methodology: While the methodology is generally sound, additional details regarding
the inclusion and exclusion criteria for studies would enhance transparency. A flow diagram
illustrating the selection process could be beneficial.
Statistical Analysis: More information on how heterogeneity was assessed and managed would
strengthen the manuscript. Additionally, discussing potential biases in the included studies
would provide a more nuanced understanding of the results.
Results Interpretation: The results section is well-organized; however, it would be helpful to
include more context regarding how these findings compare to existing literature. This would
aid readers in understanding the significance of the results.
Discussion of Limitations: While some limitations are acknowledged, a more in-depth
discussion regarding these limitations and their potential impact on the study's conclusions
would be valuable.
Clinical Implications: The practical implications of the findings should be emphasized more
clearly. Specific recommendations for healthcare providers based on the results would enhance
the manuscript's relevance to clinical practice.
Conclusion: The conclusion effectively summarizes key findings but should avoid making
overly broad claims without sufficient supporting evidence from high-quality studies.
Minor Comments
Ensure all references are up-to-date and formatted according to journal guidelines.
Consider revising some sections for clarity and conciseness to improve overall readability.
Final Recommendation
Overall, this manuscript provides valuable insights into dietary supplements' role in managing
uric acid levels. I recommend minor revisions to address the points raised above before it can be
considered for publication. Thank you for your important contribution to this field of research.
Title: Effect of Synbiotics on the Cardiovascular Risk Factors in Patients with Non- alcoholic
Fatty Liver: A GRADE Evidence Systematic Review, Meta-analysis
Version: 0 Date: 31 Jan 2025
Reviewer's report:
This manuscript addresses an important topic regarding the effectiveness and safety of dietary
supplements in managing uric acid levels. Below are my comments and suggestions for
improvement:
General Comments
The manuscript presents a timely and relevant investigation into dietary supplements, given the
increasing prevalence of hyperuricemia and its associated health issues.
The research question is clearly defined, and the study aims are well-articulated.
Strengths
Comprehensive Review: The manuscript provides a thorough review of existing literature,
which helps contextualize the study within the broader field of dietary interventions for uric
acid management.
Methodological Rigor: The use of appropriate statistical methods for analysis adds credibility to
the findings. The network meta-analysis approach is particularly suitable for comparing multiple
interventions.
Areas for Improvement
Clarity in Methodology: While the methodology is generally sound, additional details regarding
the inclusion and exclusion criteria for studies would enhance transparency. A flow diagram
illustrating the selection process could be beneficial.
Statistical Analysis: More information on how heterogeneity was assessed and managed would
strengthen the manuscript. Additionally, discussing potential biases in the included studies
would provide a more nuanced understanding of the results.
Results Interpretation: The results section is well-organized; however, it would be helpful to
include more context regarding how these findings compare to existing literature. This would
aid readers in understanding the significance of the results.
Discussion of Limitations: While some limitations are acknowledged, a more in-depth
discussion regarding these limitations and their potential impact on the study's conclusions
would be valuable.
Clinical Implications: The practical implications of the findings should be emphasized more
clearly. Specific recommendations for healthcare providers based on the results would enhance
the manuscript's relevance to clinical practice.
Conclusion: The conclusion effectively summarizes key findings but should avoid making
overly broad claims without sufficient supporting evidence from high-quality studies.
Minor Comments
Ensure all references are up-to-date and formatted according to journal guidelines.
Consider revising some sections for clarity and conciseness to improve overall readability.
Final Recommendation
Overall, this manuscript provides valuable insights into dietary supplements' role in managing
uric acid levels. I recommend minor revisions to address the points raised above before it can be
considered for publication. Thank you for your important contribution to this field of research.
Please review this paper.
user
Title: Effect of Synbiotics on the Cardiovascular Risk Factors in Patients with Non- alcoholic
Fatty Liver: A GRADE Evidence Systematic Review, Meta-analysis
Version: 0 Date: 31 Jan 2025
Reviewer's report:
This manuscript addresses an important topic regarding the effectiveness and safety of dietary
supplements in managing uric acid levels. Below are my comments and suggestions for
improvement:
General Comments
The manuscript presents a timely and relevant investigation into dietary supplements, given the
increasing prevalence of hyperuricemia and its associated health issues.
The research question is clearly defined, and the study aims are well-articulated.
Strengths
Comprehensive Review: The manuscript provides a thorough review of existing literature,
which helps contextualize the study within the broader field of dietary interventions for uric
acid management.
Methodological Rigor: The use of appropriate statistical methods for analysis adds credibility to
the findings. The network meta-analysis approach is particularly suitable for comparing multiple
interventions.
Areas for Improvement
Clarity in Methodology: While the methodology is generally sound, additional details regarding
the inclusion and exclusion criteria for studies would enhance transparency. A flow diagram
illustrating the selection process could be beneficial.
Statistical Analysis: More information on how heterogeneity was assessed and managed would
strengthen the manuscript. Additionally, discussing potential biases in the included studies
would provide a more nuanced understanding of the results.
Results Interpretation: The results section is well-organized; however, it would be helpful to
include more context regarding how these findings compare to existing literature. This would
aid readers in understanding the significance of the results.
Discussion of Limitations: While some limitations are acknowledged, a more in-depth
discussion regarding these limitations and their potential impact on the study's conclusions
would be valuable.
Clinical Implications: The practical implications of the findings should be emphasized more
clearly. Specific recommendations for healthcare providers based on the results would enhance
the manuscript's relevance to clinical practice.
Conclusion: The conclusion effectively summarizes key findings but should avoid making
overly broad claims without sufficient supporting evidence from high-quality studies.
Minor Comments
Ensure all references are up-to-date and formatted according to journal guidelines.
Consider revising some sections for clarity and conciseness to improve overall readability.
Final Recommendation
Overall, this manuscript provides valuable insights into dietary supplements' role in managing
uric acid levels. I recommend minor revisions to address the points raised above before it can be
considered for publication. Thank you for your important contribution to this field of research.
assistant