Title: Optimal Endoscopy Timing in Elderly Patients Presenting with Acute Non-Variceal
Upper Gastrointestinal Bleeding.
Version: 13 Date: 31 Oct 2024
Reviewer:  Riccardo Marmo
Reviewer's report:
Unresolved Issues In the abstract section, the authors reported that "Patients older than 65 years
had... higher 30-day mortality than younger patients." This statement is at odds with the results
and it may be helpful to remove or correct the sentence. In the Results section, authors should
include the subsection univariate and multivariate analysis. In Table 6, the authors state that
"Diabetes mellitus (HR: 0.389, 95% Cl: 0.187-0.810, p: 0.012), ... the Rockall clinical score (HR:
0.648, 95% Cl: 0.426-0.985, p: 0.042) ... were found to be independent predictors for 30-day
mortality, but a HR less than 1 is a protective factor, please explain. In the conclusion section,
you should clearly report what is the optimal timing of endoscopy in older age #65 years. In the
Table 4 and 5 is reported that mortality in the age group >65 years and the timing to endoscopy
<12 hrs is higher than the comparison group; the mortality in the age group >65 seems lower in
the timing 12/24 hours: please  verify your discussion and abstract section
Title: Optimal Endoscopy Timing in Elderly Patients Presenting with Acute Non-Variceal
Upper Gastrointestinal Bleeding.
Version: 13 Date: 31 Oct 2024
Reviewer:  Riccardo Marmo
Reviewer's report:
Unresolved Issues In the abstract section, the authors reported that "Patients older than 65 years
had... higher 30-day mortality than younger patients." This statement is at odds with the results
and it may be helpful to remove or correct the sentence. In the Results section, authors should
include the subsection univariate and multivariate analysis. In Table 6, the authors state that
"Diabetes mellitus (HR: 0.389, 95% Cl: 0.187-0.810, p: 0.012), ... the Rockall clinical score (HR:
0.648, 95% Cl: 0.426-0.985, p: 0.042) ... were found to be independent predictors for 30-day
mortality, but a HR less than 1 is a protective factor, please explain. In the conclusion section,
you should clearly report what is the optimal timing of endoscopy in older age #65 years. In the
Table 4 and 5 is reported that mortality in the age group >65 years and the timing to endoscopy
<12 hrs is higher than the comparison group; the mortality in the age group >65 seems lower in
the timing 12/24 hours: please  verify your discussion and abstract section
Please review this paper.
user
Title: Optimal Endoscopy Timing in Elderly Patients Presenting with Acute Non-Variceal
Upper Gastrointestinal Bleeding.
Version: 13 Date: 31 Oct 2024
Reviewer:  Riccardo Marmo
Reviewer's report:
Unresolved Issues In the abstract section, the authors reported that "Patients older than 65 years
had... higher 30-day mortality than younger patients." This statement is at odds with the results
and it may be helpful to remove or correct the sentence. In the Results section, authors should
include the subsection univariate and multivariate analysis. In Table 6, the authors state that
"Diabetes mellitus (HR: 0.389, 95% Cl: 0.187-0.810, p: 0.012), ... the Rockall clinical score (HR:
0.648, 95% Cl: 0.426-0.985, p: 0.042) ... were found to be independent predictors for 30-day
mortality, but a HR less than 1 is a protective factor, please explain. In the conclusion section,
you should clearly report what is the optimal timing of endoscopy in older age #65 years. In the
Table 4 and 5 is reported that mortality in the age group >65 years and the timing to endoscopy
<12 hrs is higher than the comparison group; the mortality in the age group >65 seems lower in
the timing 12/24 hours: please  verify your discussion and abstract section
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