Title: The impact of Karnofsky Performance Status on prognosis of patients with hepatocellular
carcinoma in liver transplantation
Version: 1 Date: 09 Jul 2023
Reviewer's report:
This is a simple paper using the KPS score to stratify different groups of LT patients, but focusing
on the HCC status and recurrence of the disease after LT.
What is not clear in this paper is the role of low KPS and how not influences the poorer
performance in terms of liver transplantation? It boils down to selection of patients for LT and
would there be any data regarding prehabilitation for these low KPS score patients to make them
fitter before LT?
What would be the postulation of the authors on the poorer survival of low KPS score patients
with LT for HCC with higher recurrence? Any we suggesting that low KPS is associated with
more aggressive cancer? I will find this difficult to provide concrete evidence. However, the
authors should try to address that as this is one of the. main findings in the paper.
Title: The impact of Karnofsky Performance Status on prognosis of patients with hepatocellular
carcinoma in liver transplantation
Version: 1 Date: 09 Jul 2023
Reviewer's report:
This is a simple paper using the KPS score to stratify different groups of LT patients, but focusing
on the HCC status and recurrence of the disease after LT.
What is not clear in this paper is the role of low KPS and how not influences the poorer
performance in terms of liver transplantation? It boils down to selection of patients for LT and
would there be any data regarding prehabilitation for these low KPS score patients to make them
fitter before LT?
What would be the postulation of the authors on the poorer survival of low KPS score patients
with LT for HCC with higher recurrence? Any we suggesting that low KPS is associated with
more aggressive cancer? I will find this difficult to provide concrete evidence. However, the
authors should try to address that as this is one of the. main findings in the paper.
Please review this paper.
user
Title: The impact of Karnofsky Performance Status on prognosis of patients with hepatocellular
carcinoma in liver transplantation
Version: 1 Date: 09 Jul 2023
Reviewer's report:
This is a simple paper using the KPS score to stratify different groups of LT patients, but focusing
on the HCC status and recurrence of the disease after LT.
What is not clear in this paper is the role of low KPS and how not influences the poorer
performance in terms of liver transplantation? It boils down to selection of patients for LT and
would there be any data regarding prehabilitation for these low KPS score patients to make them
fitter before LT?
What would be the postulation of the authors on the poorer survival of low KPS score patients
with LT for HCC with higher recurrence? Any we suggesting that low KPS is associated with
more aggressive cancer? I will find this difficult to provide concrete evidence. However, the
authors should try to address that as this is one of the. main findings in the paper.
assistant