Title: Effect of disease duration on the association between C-reactive protein-albumin ratio
and endoscopic activity in ulcerative colitis
Version: 1 Date: 14 Nov 2021
Reviewer's report:
This article is one of the few studies to examine the relationship between C-reactive protein
(CRP)-albumin(Alb) ratio (CAR) and disease activity in Japanese patients with inflammatory
bowel disease (IBD). It is very interesting to compare CAR and activity of Ulcerative colitis(UC)
in more than 270 patients and show that CAR may be useful as a serum marker of disease activity
in patients with longer duration of UC.
In order to improve the paper, I suggest that the following points be added.
1) The authors define clinical remission as no rectal bleeding and no more than three bowel
movements.  You should also include a clinical score, such as the Clinical activity index.
2) It would be better to show the mean values of CRP and Alb in each CAR group, because we
would like to know the factors behind the changes in CAR.
Minor
1) In the legend of Table 1, the notation of CAR should be changed from "C-protein to albumin
ratio" to "C-reactive protein to albumin ratio".
Title: Effect of disease duration on the association between C-reactive protein-albumin ratio
and endoscopic activity in ulcerative colitis
Version: 1 Date: 14 Nov 2021
Reviewer's report:
This article is one of the few studies to examine the relationship between C-reactive protein
(CRP)-albumin(Alb) ratio (CAR) and disease activity in Japanese patients with inflammatory
bowel disease (IBD). It is very interesting to compare CAR and activity of Ulcerative colitis(UC)
in more than 270 patients and show that CAR may be useful as a serum marker of disease activity
in patients with longer duration of UC.
In order to improve the paper, I suggest that the following points be added.
1) The authors define clinical remission as no rectal bleeding and no more than three bowel
movements.  You should also include a clinical score, such as the Clinical activity index.
2) It would be better to show the mean values of CRP and Alb in each CAR group, because we
would like to know the factors behind the changes in CAR.
Minor
1) In the legend of Table 1, the notation of CAR should be changed from "C-protein to albumin
ratio" to "C-reactive protein to albumin ratio".
Please review this paper.
user
Title: Effect of disease duration on the association between C-reactive protein-albumin ratio
and endoscopic activity in ulcerative colitis
Version: 1 Date: 14 Nov 2021
Reviewer's report:
This article is one of the few studies to examine the relationship between C-reactive protein
(CRP)-albumin(Alb) ratio (CAR) and disease activity in Japanese patients with inflammatory
bowel disease (IBD). It is very interesting to compare CAR and activity of Ulcerative colitis(UC)
in more than 270 patients and show that CAR may be useful as a serum marker of disease activity
in patients with longer duration of UC.
In order to improve the paper, I suggest that the following points be added.
1) The authors define clinical remission as no rectal bleeding and no more than three bowel
movements.  You should also include a clinical score, such as the Clinical activity index.
2) It would be better to show the mean values of CRP and Alb in each CAR group, because we
would like to know the factors behind the changes in CAR.
Minor
1) In the legend of Table 1, the notation of CAR should be changed from "C-protein to albumin
ratio" to "C-reactive protein to albumin ratio".
assistant