Reviewer's report
Title:Looking for Predictive Factors of Clinical Response to Adsorptive
Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis
Version: 2Date:13 January 2013
Reviewer: Abbi Saniabadi
Reviewer's report:
MS title: Looking for Predictive Factors of Clinical Response to Adsorptive
Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis,
by DR Yoko Yokoyama, and colleagues
In a retrospective setting, the authors have looked at the clinical and endoscopic
features of patients with active ulcerative colitis who may respond to selective
depletion of elevated myeloid lineage leucocytes, or otherwise, might be
non-responders. Basically an extracorporeal, non-pharmacologic treatment
strategy. A total of 43 patients with active colitis were treated in an outpatient
setting, each received 10 treatment sessions over 10 weeks. The authors
factored patients’ entry demographic variables into analyses by receiver
operating characteristic (ROC), and multiple logistic regression. They found that
patients with a short duration of UC and low cumulative corticosteroid dose at
entry were good responders, but the best responders were patients who received
the treatment immediately after a clinical relapse. Patients with a high cumulative
corticosteroid dose and those with extensive loss of the mucosal tissue at the
lesion sites were non-responders.
The manuscript is well written, the standard of the English language is high.
Likewise, the manuscript has sound and clinically relevant data. Therefore, I
have no hard words for the authors.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Reviewer's report
Title:Looking for Predictive Factors of Clinical Response to Adsorptive
Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis
Version: 2Date:13 January 2013
Reviewer: Abbi Saniabadi
Reviewer's report:
MS title: Looking for Predictive Factors of Clinical Response to Adsorptive
Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis,
by DR Yoko Yokoyama, and colleagues
In a retrospective setting, the authors have looked at the clinical and endoscopic
features of patients with active ulcerative colitis who may respond to selective
depletion of elevated myeloid lineage leucocytes, or otherwise, might be
non-responders. Basically an extracorporeal, non-pharmacologic treatment
strategy. A total of 43 patients with active colitis were treated in an outpatient
setting, each received 10 treatment sessions over 10 weeks. The authors
factored patients’ entry demographic variables into analyses by receiver
operating characteristic (ROC), and multiple logistic regression. They found that
patients with a short duration of UC and low cumulative corticosteroid dose at
entry were good responders, but the best responders were patients who received
the treatment immediately after a clinical relapse. Patients with a high cumulative
corticosteroid dose and those with extensive loss of the mucosal tissue at the
lesion sites were non-responders.
The manuscript is well written, the standard of the English language is high.
Likewise, the manuscript has sound and clinically relevant data. Therefore, I
have no hard words for the authors.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Please review this paper.
user
Reviewer's report
Title:Looking for Predictive Factors of Clinical Response to Adsorptive
Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis
Version: 2Date:13 January 2013
Reviewer: Abbi Saniabadi
Reviewer's report:
MS title: Looking for Predictive Factors of Clinical Response to Adsorptive
Granulocyte and Monocyte Apheresis in Patients with Ulcerative Colitis,
by DR Yoko Yokoyama, and colleagues
In a retrospective setting, the authors have looked at the clinical and endoscopic
features of patients with active ulcerative colitis who may respond to selective
depletion of elevated myeloid lineage leucocytes, or otherwise, might be
non-responders. Basically an extracorporeal, non-pharmacologic treatment
strategy. A total of 43 patients with active colitis were treated in an outpatient
setting, each received 10 treatment sessions over 10 weeks. The authors
factored patients’ entry demographic variables into analyses by receiver
operating characteristic (ROC), and multiple logistic regression. They found that
patients with a short duration of UC and low cumulative corticosteroid dose at
entry were good responders, but the best responders were patients who received
the treatment immediately after a clinical relapse. Patients with a high cumulative
corticosteroid dose and those with extensive loss of the mucosal tissue at the
lesion sites were non-responders.
The manuscript is well written, the standard of the English language is high.
Likewise, the manuscript has sound and clinically relevant data. Therefore, I
have no hard words for the authors.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
assistant