Title: Comprehensive Analysis of Risk Factors and Nomogram Development for Predicting
Hepatic Metastasis Following Radical Resection of Adenocarcinoma of the Esophagogastric
Junction
Version: 1 Date: 17 Mar 2025
Reviewer's report:
This paper is well-written original article concerning the risk of postoperative liver metastasis
in patients with gastric cardia cancer. The objective of this study is very curious and important,
however, there are several points that remain unclear.
Comments;
#1 Does this study include adenocarcinoma of the esophagogastric junction (AEG)? For
transthoracic cases, does this imply that esophageal invasion was present?
#2 Was P53 evaluated using immunohistochemistry (IHC)? If so, details regarding the antibody
type and staining protocol should be described in the Methods section. What is the reason for
measuring Ki-67, and what cut-off value was used?
#3 What does "transthoracic gastrectomy" refer to in this study? Please clarify the specific
surgical procedure.
#4 This manuscript states that "The thoraco-abdominal approach is associated with more
postoperative complications, which may affect prognosis," however no complication data are
provided. The complication data is necessary to support this statement.
#5 The Discussion section currently describes each risk factor separately. To improve clarity
and coherence, it should be systematically structured with a summary, background knowledge,
comparison with previous studies, study limitations, and interpretation of the results.
Title: Comprehensive Analysis of Risk Factors and Nomogram Development for Predicting
Hepatic Metastasis Following Radical Resection of Adenocarcinoma of the Esophagogastric
Junction
Version: 1 Date: 17 Mar 2025
Reviewer's report:
This paper is well-written original article concerning the risk of postoperative liver metastasis
in patients with gastric cardia cancer. The objective of this study is very curious and important,
however, there are several points that remain unclear.
Comments;
#1 Does this study include adenocarcinoma of the esophagogastric junction (AEG)? For
transthoracic cases, does this imply that esophageal invasion was present?
#2 Was P53 evaluated using immunohistochemistry (IHC)? If so, details regarding the antibody
type and staining protocol should be described in the Methods section. What is the reason for
measuring Ki-67, and what cut-off value was used?
#3 What does "transthoracic gastrectomy" refer to in this study? Please clarify the specific
surgical procedure.
#4 This manuscript states that "The thoraco-abdominal approach is associated with more
postoperative complications, which may affect prognosis," however no complication data are
provided. The complication data is necessary to support this statement.
#5 The Discussion section currently describes each risk factor separately. To improve clarity
and coherence, it should be systematically structured with a summary, background knowledge,
comparison with previous studies, study limitations, and interpretation of the results.
Please review this paper.
user
Title: Comprehensive Analysis of Risk Factors and Nomogram Development for Predicting
Hepatic Metastasis Following Radical Resection of Adenocarcinoma of the Esophagogastric
Junction
Version: 1 Date: 17 Mar 2025
Reviewer's report:
This paper is well-written original article concerning the risk of postoperative liver metastasis
in patients with gastric cardia cancer. The objective of this study is very curious and important,
however, there are several points that remain unclear.
Comments;
#1 Does this study include adenocarcinoma of the esophagogastric junction (AEG)? For
transthoracic cases, does this imply that esophageal invasion was present?
#2 Was P53 evaluated using immunohistochemistry (IHC)? If so, details regarding the antibody
type and staining protocol should be described in the Methods section. What is the reason for
measuring Ki-67, and what cut-off value was used?
#3 What does "transthoracic gastrectomy" refer to in this study? Please clarify the specific
surgical procedure.
#4 This manuscript states that "The thoraco-abdominal approach is associated with more
postoperative complications, which may affect prognosis," however no complication data are
provided. The complication data is necessary to support this statement.
#5 The Discussion section currently describes each risk factor separately. To improve clarity
and coherence, it should be systematically structured with a summary, background knowledge,
comparison with previous studies, study limitations, and interpretation of the results.
assistant