Title: Effect of Synbiotics on the Cardiovascular Risk Factors in Patients with Non- alcoholic
Fatty Liver: A GRADE Evidence Systematic Review, Meta-analysis
Version: 1 Date: 11 Mar 2025
Reviewer's report:
The manuscript presents a systematic review and meta-analysis assessing the effects of synbiotic
supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease
(NAFLD). The study is timely and addresses an important clinical question, given the increasing
prevalence of NAFLD globally. The authors have employed rigorous methodologies, including
adherence to PRISMA guidelines, use of the GRADE approach for evidence quality assessment,
and robust statistical analyses. However, several areas require improvement to enhance clarity,
scientific rigor, and presentation.
Strengths
Relevance: The topic is significant in addressing the role of gut microbiota modulation in
NAFLD management, which is a growing area of interest.
Methodological Rigor: The use of PRISMA guidelines, PROSPERO registration, and
comprehensive statistical techniques (e.g., meta-regression, sensitivity analysis) strengthens the
reliability of findings.
Transparency: The inclusion of detailed descriptions on study selection criteria, risk of bias
assessment, and publication bias evaluation adds credibility.
Focus on NAFLD: Unlike previous meta-analyses that target broader populations, this
manuscript specifically focuses on NAFLD patients, providing more targeted insights.
Conclusion
The manuscript is a valuable contribution to understanding the role of synbiotics in managing
cardiovascular risk factors among NAFLD patients.
Title: Effect of Synbiotics on the Cardiovascular Risk Factors in Patients with Non- alcoholic
Fatty Liver: A GRADE Evidence Systematic Review, Meta-analysis
Version: 1 Date: 11 Mar 2025
Reviewer's report:
The manuscript presents a systematic review and meta-analysis assessing the effects of synbiotic
supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease
(NAFLD). The study is timely and addresses an important clinical question, given the increasing
prevalence of NAFLD globally. The authors have employed rigorous methodologies, including
adherence to PRISMA guidelines, use of the GRADE approach for evidence quality assessment,
and robust statistical analyses. However, several areas require improvement to enhance clarity,
scientific rigor, and presentation.
Strengths
Relevance: The topic is significant in addressing the role of gut microbiota modulation in
NAFLD management, which is a growing area of interest.
Methodological Rigor: The use of PRISMA guidelines, PROSPERO registration, and
comprehensive statistical techniques (e.g., meta-regression, sensitivity analysis) strengthens the
reliability of findings.
Transparency: The inclusion of detailed descriptions on study selection criteria, risk of bias
assessment, and publication bias evaluation adds credibility.
Focus on NAFLD: Unlike previous meta-analyses that target broader populations, this
manuscript specifically focuses on NAFLD patients, providing more targeted insights.
Conclusion
The manuscript is a valuable contribution to understanding the role of synbiotics in managing
cardiovascular risk factors among NAFLD patients.
Please review this paper.
user
Title: Effect of Synbiotics on the Cardiovascular Risk Factors in Patients with Non- alcoholic
Fatty Liver: A GRADE Evidence Systematic Review, Meta-analysis
Version: 1 Date: 11 Mar 2025
Reviewer's report:
The manuscript presents a systematic review and meta-analysis assessing the effects of synbiotic
supplementation on cardiovascular risk factors in patients with non-alcoholic fatty liver disease
(NAFLD). The study is timely and addresses an important clinical question, given the increasing
prevalence of NAFLD globally. The authors have employed rigorous methodologies, including
adherence to PRISMA guidelines, use of the GRADE approach for evidence quality assessment,
and robust statistical analyses. However, several areas require improvement to enhance clarity,
scientific rigor, and presentation.
Strengths
Relevance: The topic is significant in addressing the role of gut microbiota modulation in
NAFLD management, which is a growing area of interest.
Methodological Rigor: The use of PRISMA guidelines, PROSPERO registration, and
comprehensive statistical techniques (e.g., meta-regression, sensitivity analysis) strengthens the
reliability of findings.
Transparency: The inclusion of detailed descriptions on study selection criteria, risk of bias
assessment, and publication bias evaluation adds credibility.
Focus on NAFLD: Unlike previous meta-analyses that target broader populations, this
manuscript specifically focuses on NAFLD patients, providing more targeted insights.
Conclusion
The manuscript is a valuable contribution to understanding the role of synbiotics in managing
cardiovascular risk factors among NAFLD patients.
assistant