Title: Portal Vein Thrombosis and Esophageal-Gastric Variceal Bleeding in Cirrhosis: Shared
Risk Factors and Causal Relationship
Version: 2 Date: 18 Apr 2025
Reviewer's report:
The author clarified some issues, but there are still some parts that need to be further clarified
1. The author acknowledges that excluding patients who underwent surgical treatment during
the follow-up period would have an impact on the final outcome, but insisting on it,
which is questionable. It is incorrect to directly exclude these patients, because there are no
exclusion indications for these patients before treatment. Postoperative treatments such as liver
transplantation or splenectomy should be regarded as competing events for outcomes. Such
handling can minimize the confounding factors introduced by surgical treatment and increase
the number of patients at the same time. The impact of excessive exclusion of patients on the
outcome is very direct. The author did not specify how much the exclusion of this group of
patients affected the outcome, which casts doubt on the research results.
2. The author needs to cite literature on the reasons for age grouping to enhance persuasiveness.
Title: Portal Vein Thrombosis and Esophageal-Gastric Variceal Bleeding in Cirrhosis: Shared
Risk Factors and Causal Relationship
Version: 2 Date: 18 Apr 2025
Reviewer's report:
The author clarified some issues, but there are still some parts that need to be further clarified
1. The author acknowledges that excluding patients who underwent surgical treatment during
the follow-up period would have an impact on the final outcome, but insisting on it,
which is questionable. It is incorrect to directly exclude these patients, because there are no
exclusion indications for these patients before treatment. Postoperative treatments such as liver
transplantation or splenectomy should be regarded as competing events for outcomes. Such
handling can minimize the confounding factors introduced by surgical treatment and increase
the number of patients at the same time. The impact of excessive exclusion of patients on the
outcome is very direct. The author did not specify how much the exclusion of this group of
patients affected the outcome, which casts doubt on the research results.
2. The author needs to cite literature on the reasons for age grouping to enhance persuasiveness.
Please review this paper.
user
Title: Portal Vein Thrombosis and Esophageal-Gastric Variceal Bleeding in Cirrhosis: Shared
Risk Factors and Causal Relationship
Version: 2 Date: 18 Apr 2025
Reviewer's report:
The author clarified some issues, but there are still some parts that need to be further clarified
1. The author acknowledges that excluding patients who underwent surgical treatment during
the follow-up period would have an impact on the final outcome, but insisting on it,
which is questionable. It is incorrect to directly exclude these patients, because there are no
exclusion indications for these patients before treatment. Postoperative treatments such as liver
transplantation or splenectomy should be regarded as competing events for outcomes. Such
handling can minimize the confounding factors introduced by surgical treatment and increase
the number of patients at the same time. The impact of excessive exclusion of patients on the
outcome is very direct. The author did not specify how much the exclusion of this group of
patients affected the outcome, which casts doubt on the research results.
2. The author needs to cite literature on the reasons for age grouping to enhance persuasiveness.
assistant