Title: Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in
patients with chronic constipation
Version: 0 Date: 24 Jul 2021
Reviewer's report:
This is a well written manuscript assessing an effectiveness and safety of the use of macrogol
4000 in addition to PEG before colonoscopy for patients with chronic constipation. This is the
first prospective study on the use of macrogol 4000 as a bowel-cleansing agent. Authors analyzed
a total of 40 patients and demonstrated clearly that the rate of good preparation is 92.5% (37/40)
and no adverse events were observed.
1. P8. line137. Tough authors described “All patients received a PEG dose of 1500 mL even if
the colonoscopy could be started when they had taken less than this amount.”, they described
“PEG taken, mL (range) = 1500 (1000-2000)” in Table 3. Were there patients who ingested only
1000ml of PEG in 40 cases? Please clarify it.
2. P12. line217. Not only constipation and diabetes but also inpatient status and tricyclic
antidepressant use are also known to be associated with inadequate bowel preparation. Please
clarify performance status and antidepressants use of the 40 cases, if possible.
3. P17. Line256. The authors described “A significantly greater proportion of patients rated the
tolerability of macrogol 4000 as good compared with PEG (95.0% vs. 50.0%, p < 0.01).”. The
amount of PEG is 1500ml, which is 6 times that of macrogol 4000. I think there is little meaning
to compare the tolerability of them.
4. ADR and PDR might be affected by previous colonoscopy and it`s bowel preparation. It will
be wonderful, if authors could report them of the 40 cases.
5. In this study, intake of macrogol 4000 in addition to PEG was effective and safe for
colonoscopy in patients with chronic constipation who could ingest 1500ml of PEG. Authors
should write about it in limitation section.
Title: Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in
patients with chronic constipation
Version: 0 Date: 24 Jul 2021
Reviewer's report:
This is a well written manuscript assessing an effectiveness and safety of the use of macrogol
4000 in addition to PEG before colonoscopy for patients with chronic constipation. This is the
first prospective study on the use of macrogol 4000 as a bowel-cleansing agent. Authors analyzed
a total of 40 patients and demonstrated clearly that the rate of good preparation is 92.5% (37/40)
and no adverse events were observed.
1. P8. line137. Tough authors described “All patients received a PEG dose of 1500 mL even if
the colonoscopy could be started when they had taken less than this amount.”, they described
“PEG taken, mL (range) = 1500 (1000-2000)” in Table 3. Were there patients who ingested only
1000ml of PEG in 40 cases? Please clarify it.
2. P12. line217. Not only constipation and diabetes but also inpatient status and tricyclic
antidepressant use are also known to be associated with inadequate bowel preparation. Please
clarify performance status and antidepressants use of the 40 cases, if possible.
3. P17. Line256. The authors described “A significantly greater proportion of patients rated the
tolerability of macrogol 4000 as good compared with PEG (95.0% vs. 50.0%, p < 0.01).”. The
amount of PEG is 1500ml, which is 6 times that of macrogol 4000. I think there is little meaning
to compare the tolerability of them.
4. ADR and PDR might be affected by previous colonoscopy and it`s bowel preparation. It will
be wonderful, if authors could report them of the 40 cases.
5. In this study, intake of macrogol 4000 in addition to PEG was effective and safe for
colonoscopy in patients with chronic constipation who could ingest 1500ml of PEG. Authors
should write about it in limitation section.
Please review this paper.
user
Title: Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in
patients with chronic constipation
Version: 0 Date: 24 Jul 2021
Reviewer's report:
This is a well written manuscript assessing an effectiveness and safety of the use of macrogol
4000 in addition to PEG before colonoscopy for patients with chronic constipation. This is the
first prospective study on the use of macrogol 4000 as a bowel-cleansing agent. Authors analyzed
a total of 40 patients and demonstrated clearly that the rate of good preparation is 92.5% (37/40)
and no adverse events were observed.
1. P8. line137. Tough authors described “All patients received a PEG dose of 1500 mL even if
the colonoscopy could be started when they had taken less than this amount.”, they described
“PEG taken, mL (range) = 1500 (1000-2000)” in Table 3. Were there patients who ingested only
1000ml of PEG in 40 cases? Please clarify it.
2. P12. line217. Not only constipation and diabetes but also inpatient status and tricyclic
antidepressant use are also known to be associated with inadequate bowel preparation. Please
clarify performance status and antidepressants use of the 40 cases, if possible.
3. P17. Line256. The authors described “A significantly greater proportion of patients rated the
tolerability of macrogol 4000 as good compared with PEG (95.0% vs. 50.0%, p < 0.01).”. The
amount of PEG is 1500ml, which is 6 times that of macrogol 4000. I think there is little meaning
to compare the tolerability of them.
4. ADR and PDR might be affected by previous colonoscopy and it`s bowel preparation. It will
be wonderful, if authors could report them of the 40 cases.
5. In this study, intake of macrogol 4000 in addition to PEG was effective and safe for
colonoscopy in patients with chronic constipation who could ingest 1500ml of PEG. Authors
should write about it in limitation section.
assistant