Title: Development and application of an artificial intelligence-assisted endoscopy system for
diagnosis of Helicobacter pylori infection: a multicenter randomized controlled study
Version: 1 Date: 01 Apr 2024
Reviewer:  Stephen Lanspa
Reviewer's report:
Well written report concerning an important public health problem.
1.  The gold standard was completion of two or more diagnostic tests (UBT, RUT, H. pylori
culture, H. pylori histology) with consistent results. The authors express the benefits of “realtime
diagnosis” of Hp, but it may be helpful to add a paragraph further defending this (cost,
convenience, in the future might confirmation tests be eliminated?). Why is an immediate result
needed?
2. In describing the CNN it may be helpful to add demonstrative pictures of gastric mucosa.
Convince skeptics that AI is additive.
3.  The authors address the problem of prior treatment for H. pylori.  Would it be acceptable to
speculate how this might be addressed in future studies or population screening?
Title: Development and application of an artificial intelligence-assisted endoscopy system for
diagnosis of Helicobacter pylori infection: a multicenter randomized controlled study
Version: 1 Date: 01 Apr 2024
Reviewer:  Stephen Lanspa
Reviewer's report:
Well written report concerning an important public health problem.
1.  The gold standard was completion of two or more diagnostic tests (UBT, RUT, H. pylori
culture, H. pylori histology) with consistent results. The authors express the benefits of “realtime
diagnosis” of Hp, but it may be helpful to add a paragraph further defending this (cost,
convenience, in the future might confirmation tests be eliminated?). Why is an immediate result
needed?
2. In describing the CNN it may be helpful to add demonstrative pictures of gastric mucosa.
Convince skeptics that AI is additive.
3.  The authors address the problem of prior treatment for H. pylori.  Would it be acceptable to
speculate how this might be addressed in future studies or population screening?
Please review this paper.
user
Title: Development and application of an artificial intelligence-assisted endoscopy system for
diagnosis of Helicobacter pylori infection: a multicenter randomized controlled study
Version: 1 Date: 01 Apr 2024
Reviewer:  Stephen Lanspa
Reviewer's report:
Well written report concerning an important public health problem.
1.  The gold standard was completion of two or more diagnostic tests (UBT, RUT, H. pylori
culture, H. pylori histology) with consistent results. The authors express the benefits of “realtime
diagnosis” of Hp, but it may be helpful to add a paragraph further defending this (cost,
convenience, in the future might confirmation tests be eliminated?). Why is an immediate result
needed?
2. In describing the CNN it may be helpful to add demonstrative pictures of gastric mucosa.
Convince skeptics that AI is additive.
3.  The authors address the problem of prior treatment for H. pylori.  Would it be acceptable to
speculate how this might be addressed in future studies or population screening?
assistant