Reviewer's report
Title:Duodenal carcinoma at the ligament of Treitz. A molecular and clinical
perspective.
Version: 1Date:2 July 2010
Reviewer: Adriana Safatle-Ribeiro
Reviewer's report:
This is a case report and a review of the literature about carcinoma of the
duodenum and how important is to make the early diagnosis of such lesion.
However, this case cleared demonstrated the delayed diagnosis due to the lack
of clinical suspicion. Nowadays, obscure GI bleeding is a formerly indication for
an investigation through capsule endoscopy and balloon assisted enteroscopy
(DBE or SBE).
Despite of an extensive review of the literature into the discussion, about double
balloon endoscopy and radiologic tests, the authors did not indicate them to the
specific case. Fortunately, the lesion could be reached by push-enteroscopy.
Additionally, the genetic markers discussed were not analyzed by the authors
(except EGFR, which was negative). Maybe, the authors could study other
markers, since the patient presents adenomas in the colon. Please, comment.
The authors did not mention the type of reconstruction and if the patient received
or not adjuvant treatment. Please discuss.
The discussion is too long and should be reduced, as well as the number of
references.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Duodenal carcinoma at the ligament of Treitz. A molecular and clinical
perspective.
Version: 1Date:2 July 2010
Reviewer: Adriana Safatle-Ribeiro
Reviewer's report:
This is a case report and a review of the literature about carcinoma of the
duodenum and how important is to make the early diagnosis of such lesion.
However, this case cleared demonstrated the delayed diagnosis due to the lack
of clinical suspicion. Nowadays, obscure GI bleeding is a formerly indication for
an investigation through capsule endoscopy and balloon assisted enteroscopy
(DBE or SBE).
Despite of an extensive review of the literature into the discussion, about double
balloon endoscopy and radiologic tests, the authors did not indicate them to the
specific case. Fortunately, the lesion could be reached by push-enteroscopy.
Additionally, the genetic markers discussed were not analyzed by the authors
(except EGFR, which was negative). Maybe, the authors could study other
markers, since the patient presents adenomas in the colon. Please, comment.
The authors did not mention the type of reconstruction and if the patient received
or not adjuvant treatment. Please discuss.
The discussion is too long and should be reduced, as well as the number of
references.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Duodenal carcinoma at the ligament of Treitz. A molecular and clinical
perspective.
Version: 1Date:2 July 2010
Reviewer: Adriana Safatle-Ribeiro
Reviewer's report:
This is a case report and a review of the literature about carcinoma of the
duodenum and how important is to make the early diagnosis of such lesion.
However, this case cleared demonstrated the delayed diagnosis due to the lack
of clinical suspicion. Nowadays, obscure GI bleeding is a formerly indication for
an investigation through capsule endoscopy and balloon assisted enteroscopy
(DBE or SBE).
Despite of an extensive review of the literature into the discussion, about double
balloon endoscopy and radiologic tests, the authors did not indicate them to the
specific case. Fortunately, the lesion could be reached by push-enteroscopy.
Additionally, the genetic markers discussed were not analyzed by the authors
(except EGFR, which was negative). Maybe, the authors could study other
markers, since the patient presents adenomas in the colon. Please, comment.
The authors did not mention the type of reconstruction and if the patient received
or not adjuvant treatment. Please discuss.
The discussion is too long and should be reduced, as well as the number of
references.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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