Reviewer's report
Title:Gaviscon(R) vs. omeprazole in symptomatic treatment of moderate
gastroesophageal reflux. A direct comparative randomised trial
Version: 3Date:2 December 2011
Reviewer: Guido Tytgat
Reviewer's report:
major:interesting study,long overdue.The endpoint:24h heartburn free day at d7
is confusing.It is not at d7.This should be rephrased.Surprisingly no mention is
made of the acid pocket,related to gaviscon
minor
p5:what is beas resistance?
p7:exact composition of gaviscon and of the placebo should be given.The
precise instructions regarding the precise timing of intake of the study drugs
should be given.
p12>at which time did syptoms recur in the gaviscon arm?What is
úlcerative'esophagitis?
p13:what is 'moderate'gerd? what is 'raft of beads'?
p14:what are 'moderate'sumptoms?...ackward sentence:...reduce excessive use
of curative or preventive RATHER THAN PPIs.
Tables:What is the precise 'heartburn intensity score'.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Gaviscon(R) vs. omeprazole in symptomatic treatment of moderate
gastroesophageal reflux. A direct comparative randomised trial
Version: 3Date:2 December 2011
Reviewer: Guido Tytgat
Reviewer's report:
major:interesting study,long overdue.The endpoint:24h heartburn free day at d7
is confusing.It is not at d7.This should be rephrased.Surprisingly no mention is
made of the acid pocket,related to gaviscon
minor
p5:what is beas resistance?
p7:exact composition of gaviscon and of the placebo should be given.The
precise instructions regarding the precise timing of intake of the study drugs
should be given.
p12>at which time did syptoms recur in the gaviscon arm?What is
úlcerative'esophagitis?
p13:what is 'moderate'gerd? what is 'raft of beads'?
p14:what are 'moderate'sumptoms?...ackward sentence:...reduce excessive use
of curative or preventive RATHER THAN PPIs.
Tables:What is the precise 'heartburn intensity score'.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Gaviscon(R) vs. omeprazole in symptomatic treatment of moderate
gastroesophageal reflux. A direct comparative randomised trial
Version: 3Date:2 December 2011
Reviewer: Guido Tytgat
Reviewer's report:
major:interesting study,long overdue.The endpoint:24h heartburn free day at d7
is confusing.It is not at d7.This should be rephrased.Surprisingly no mention is
made of the acid pocket,related to gaviscon
minor
p5:what is beas resistance?
p7:exact composition of gaviscon and of the placebo should be given.The
precise instructions regarding the precise timing of intake of the study drugs
should be given.
p12>at which time did syptoms recur in the gaviscon arm?What is
úlcerative'esophagitis?
p13:what is 'moderate'gerd? what is 'raft of beads'?
p14:what are 'moderate'sumptoms?...ackward sentence:...reduce excessive use
of curative or preventive RATHER THAN PPIs.
Tables:What is the precise 'heartburn intensity score'.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant