Title: Association of liver related biomarkers with incident cardiovascular disease and all-
cause mortality in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a
population-based cohort study
Version: 2 Date: 12 May 2025
Reviewer's report:
Dear Authors ,
I read and analyzed your article carefully. Below my suggestions:
Abstract
In the abstract the aim of the study should be more clearly described. Results and conclusion
should answer the questions addressed in the aim.
Introduction
The introduction section lacks the purpose of the study, clearly define the hypothesis and
emphasize clinical relevance of this study.
Statistical analysis
Although the HCHS/SOL is composed by more than 16000 participants, the sample size of the
cohort with outcome is composed by 740 participants. The statistical analysis lacks a power
calculation—clarify if the study was sufficiently powered to detect significant differences.
Considering the pivotal role of statistical analysis in this paper, a statistician should be present
in the author’s list.
Results
Please report the p-values in the text when you describe significant differences between groups.
It is not clear to me why did you add the variables “center” and “AHEI2010” in the multivariate
analysis. It would be of interest the introduction of hepatitis status in the multivariate analysis.
The sections regarding the Hispanic background and gender difference should be clearly
reported and not only as supplementary data.
Tables and figures
In figure 2 please add the statistical deviation and the measure unity in the y-axis. Kaplan-Meier
curves are suggested.
Discussion and Conclusion
Although the discussion is scientifically strong and well-referenced, it should be emphasize the
clinical relevance of this study.
Title: Association of liver related biomarkers with incident cardiovascular disease and all-
cause mortality in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a
population-based cohort study
Version: 2 Date: 12 May 2025
Reviewer's report:
Dear Authors ,
I read and analyzed your article carefully. Below my suggestions:
Abstract
In the abstract the aim of the study should be more clearly described. Results and conclusion
should answer the questions addressed in the aim.
Introduction
The introduction section lacks the purpose of the study, clearly define the hypothesis and
emphasize clinical relevance of this study.
Statistical analysis
Although the HCHS/SOL is composed by more than 16000 participants, the sample size of the
cohort with outcome is composed by 740 participants. The statistical analysis lacks a power
calculation—clarify if the study was sufficiently powered to detect significant differences.
Considering the pivotal role of statistical analysis in this paper, a statistician should be present
in the author’s list.
Results
Please report the p-values in the text when you describe significant differences between groups.
It is not clear to me why did you add the variables “center” and “AHEI2010” in the multivariate
analysis. It would be of interest the introduction of hepatitis status in the multivariate analysis.
The sections regarding the Hispanic background and gender difference should be clearly
reported and not only as supplementary data.
Tables and figures
In figure 2 please add the statistical deviation and the measure unity in the y-axis. Kaplan-Meier
curves are suggested.
Discussion and Conclusion
Although the discussion is scientifically strong and well-referenced, it should be emphasize the
clinical relevance of this study.
Please review this paper.
user
Title: Association of liver related biomarkers with incident cardiovascular disease and all-
cause mortality in the Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a
population-based cohort study
Version: 2 Date: 12 May 2025
Reviewer's report:
Dear Authors ,
I read and analyzed your article carefully. Below my suggestions:
Abstract
In the abstract the aim of the study should be more clearly described. Results and conclusion
should answer the questions addressed in the aim.
Introduction
The introduction section lacks the purpose of the study, clearly define the hypothesis and
emphasize clinical relevance of this study.
Statistical analysis
Although the HCHS/SOL is composed by more than 16000 participants, the sample size of the
cohort with outcome is composed by 740 participants. The statistical analysis lacks a power
calculation—clarify if the study was sufficiently powered to detect significant differences.
Considering the pivotal role of statistical analysis in this paper, a statistician should be present
in the author’s list.
Results
Please report the p-values in the text when you describe significant differences between groups.
It is not clear to me why did you add the variables “center” and “AHEI2010” in the multivariate
analysis. It would be of interest the introduction of hepatitis status in the multivariate analysis.
The sections regarding the Hispanic background and gender difference should be clearly
reported and not only as supplementary data.
Tables and figures
In figure 2 please add the statistical deviation and the measure unity in the y-axis. Kaplan-Meier
curves are suggested.
Discussion and Conclusion
Although the discussion is scientifically strong and well-referenced, it should be emphasize the
clinical relevance of this study.
assistant