Title: Efficacy and safety of subanesthetic doses of esketamine combined with propofol in
painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial
Version: 4 Date: 17 Jul 2022
Reviewer's report:
I do not think all the comments have been addressed. I want to know how many patients
underwent upper GI endoscopy and how many underwent colonoscopy, and if there was any
difference between the 2 groups. The 2 procedures being quite different, it is extremely important
to address the effect of the new drug on the outcome of each individual procedure. Unless we
know the distribution of patients in each category, there is a chance that the results from one
of the procedure skews the entire results, and is mistakenly applied to patients undergoing the
other procedure. Unless this has been addressed, I don't think this is fit for publication.
Title: Efficacy and safety of subanesthetic doses of esketamine combined with propofol in
painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial
Version: 4 Date: 17 Jul 2022
Reviewer's report:
I do not think all the comments have been addressed. I want to know how many patients
underwent upper GI endoscopy and how many underwent colonoscopy, and if there was any
difference between the 2 groups. The 2 procedures being quite different, it is extremely important
to address the effect of the new drug on the outcome of each individual procedure. Unless we
know the distribution of patients in each category, there is a chance that the results from one
of the procedure skews the entire results, and is mistakenly applied to patients undergoing the
other procedure. Unless this has been addressed, I don't think this is fit for publication.
Please review this paper.
user
Title: Efficacy and safety of subanesthetic doses of esketamine combined with propofol in
painless gastrointestinal endoscopy: a prospective, double-blind, randomized controlled trial
Version: 4 Date: 17 Jul 2022
Reviewer's report:
I do not think all the comments have been addressed. I want to know how many patients
underwent upper GI endoscopy and how many underwent colonoscopy, and if there was any
difference between the 2 groups. The 2 procedures being quite different, it is extremely important
to address the effect of the new drug on the outcome of each individual procedure. Unless we
know the distribution of patients in each category, there is a chance that the results from one
of the procedure skews the entire results, and is mistakenly applied to patients undergoing the
other procedure. Unless this has been addressed, I don't think this is fit for publication.
assistant