Title: Glucocorticoids in Acute Pancreatitis: A Propensity Score Matching Analysis
Version: 2 Date: 03 May 2021
Reviewer's report:
This is a report regarding whether clinicians should use glucocorticoid in routine treatment
against acute pancreatitis. Though the subject of current study is quite pratical, I have certain
concerns for this work.
First, lots of previous reports, including RCTs and meta-analysis have been conducted for this
field. I noticed that few publications within the last 5 years have been listed in the reference part
of this paper. I wonder if this study, which is an observational one, could be more convincing
than previous studies.
Second, the authors used PSM to circumvent bias of age, gender, APACHE II and SOFA. What
about other parameters, e.g., marshall score, BISAP, SIRS, etc?
Third, I care about the impact of glucocorticoid on infection rate of AP patients, as use of
antibiotics is significantly involved in pancreas infection, the authors should address antibiotics
use in their study.
Title: Glucocorticoids in Acute Pancreatitis: A Propensity Score Matching Analysis
Version: 2 Date: 03 May 2021
Reviewer's report:
This is a report regarding whether clinicians should use glucocorticoid in routine treatment
against acute pancreatitis. Though the subject of current study is quite pratical, I have certain
concerns for this work.
First, lots of previous reports, including RCTs and meta-analysis have been conducted for this
field. I noticed that few publications within the last 5 years have been listed in the reference part
of this paper. I wonder if this study, which is an observational one, could be more convincing
than previous studies.
Second, the authors used PSM to circumvent bias of age, gender, APACHE II and SOFA. What
about other parameters, e.g., marshall score, BISAP, SIRS, etc?
Third, I care about the impact of glucocorticoid on infection rate of AP patients, as use of
antibiotics is significantly involved in pancreas infection, the authors should address antibiotics
use in their study.
Please review this paper.
user
Title: Glucocorticoids in Acute Pancreatitis: A Propensity Score Matching Analysis
Version: 2 Date: 03 May 2021
Reviewer's report:
This is a report regarding whether clinicians should use glucocorticoid in routine treatment
against acute pancreatitis. Though the subject of current study is quite pratical, I have certain
concerns for this work.
First, lots of previous reports, including RCTs and meta-analysis have been conducted for this
field. I noticed that few publications within the last 5 years have been listed in the reference part
of this paper. I wonder if this study, which is an observational one, could be more convincing
than previous studies.
Second, the authors used PSM to circumvent bias of age, gender, APACHE II and SOFA. What
about other parameters, e.g., marshall score, BISAP, SIRS, etc?
Third, I care about the impact of glucocorticoid on infection rate of AP patients, as use of
antibiotics is significantly involved in pancreas infection, the authors should address antibiotics
use in their study.
assistant