Reviewer's report
Title:The VEGF -634G>C promoter polymorphism is associated with risk of
gastric cancer
Version: 1Date:26 June 2009
Reviewer: Annamaria Ruzzo
Reviewer's report:
The manuscript by Guan et al reports that exist an association between gastric
cancer and VEGF -634 G/C polymorphism.
There are some important points unclear:
1. Gastric cancer consists of two pathological variants, intestinal and diffuse: how
many patients in this study are intestinal? how many diffuse?
2. The association of Helicobacter Pylori(HP) and gastric cancer is well
established and Authors underlay this statement under “introduction”, but at the
same time they don’t mention if samples are or not infected by HP. HP is more
diffuse in Asians than Caucasians, but this is not a good reason for not reporting
this information among variables.
3. What the author mean with Non-Hispanic white? The term Caucasian race
(also Caucasoid or Europid) has been used to denote the general physical type
of some or all of the indigenous populations of Europe, North Africa, the Horn of
Africa, West Asia, Central Asia and South Asia (The Races of Europe by Carlton
Stevens Coon. From Chapter XI: ).
3. Authors report under “TGFB1 and VEGF genotypes and risk of gastric cancer”
that the SNPs were all in agreement with H-W equilibrium except for TGFB1 -509
C/T and VEGF -634 G/C. The VEGF -634 G/C is the only SNP associated with
gastric cancer. In my opinion the H-W disequilibrium for VEGF -634 can influence
the results reported and address researchers to wrong conclusions.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:The VEGF -634G>C promoter polymorphism is associated with risk of
gastric cancer
Version: 1Date:26 June 2009
Reviewer: Annamaria Ruzzo
Reviewer's report:
The manuscript by Guan et al reports that exist an association between gastric
cancer and VEGF -634 G/C polymorphism.
There are some important points unclear:
1. Gastric cancer consists of two pathological variants, intestinal and diffuse: how
many patients in this study are intestinal? how many diffuse?
2. The association of Helicobacter Pylori(HP) and gastric cancer is well
established and Authors underlay this statement under “introduction”, but at the
same time they don’t mention if samples are or not infected by HP. HP is more
diffuse in Asians than Caucasians, but this is not a good reason for not reporting
this information among variables.
3. What the author mean with Non-Hispanic white? The term Caucasian race
(also Caucasoid or Europid) has been used to denote the general physical type
of some or all of the indigenous populations of Europe, North Africa, the Horn of
Africa, West Asia, Central Asia and South Asia (The Races of Europe by Carlton
Stevens Coon. From Chapter XI: ).
3. Authors report under “TGFB1 and VEGF genotypes and risk of gastric cancer”
that the SNPs were all in agreement with H-W equilibrium except for TGFB1 -509
C/T and VEGF -634 G/C. The VEGF -634 G/C is the only SNP associated with
gastric cancer. In my opinion the H-W disequilibrium for VEGF -634 can influence
the results reported and address researchers to wrong conclusions.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:The VEGF -634G>C promoter polymorphism is associated with risk of
gastric cancer
Version: 1Date:26 June 2009
Reviewer: Annamaria Ruzzo
Reviewer's report:
The manuscript by Guan et al reports that exist an association between gastric
cancer and VEGF -634 G/C polymorphism.
There are some important points unclear:
1. Gastric cancer consists of two pathological variants, intestinal and diffuse: how
many patients in this study are intestinal? how many diffuse?
2. The association of Helicobacter Pylori(HP) and gastric cancer is well
established and Authors underlay this statement under “introduction”, but at the
same time they don’t mention if samples are or not infected by HP. HP is more
diffuse in Asians than Caucasians, but this is not a good reason for not reporting
this information among variables.
3. What the author mean with Non-Hispanic white? The term Caucasian race
(also Caucasoid or Europid) has been used to denote the general physical type
of some or all of the indigenous populations of Europe, North Africa, the Horn of
Africa, West Asia, Central Asia and South Asia (The Races of Europe by Carlton
Stevens Coon. From Chapter XI: ).
3. Authors report under “TGFB1 and VEGF genotypes and risk of gastric cancer”
that the SNPs were all in agreement with H-W equilibrium except for TGFB1 -509
C/T and VEGF -634 G/C. The VEGF -634 G/C is the only SNP associated with
gastric cancer. In my opinion the H-W disequilibrium for VEGF -634 can influence
the results reported and address researchers to wrong conclusions.
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant