Title: Efficacy and safety of direct-acting antiviral regimen for patients with hepatitis C virus
genotype 2: a systematic review and meta-analysis
Version: 4 Date: 25 Aug 2024
Reviewer's report:
The manuscript changes appear appropriate and acceptable.
I would suggest the following improvements
1. Noticed one typo - this can be easily corrected.  Kindly recheck your  whole document.
2. The conclusions should be clearly illustrated by the results  e.g.
Regime A     response rate  92 %,  ( 95%CI ;   90%, 94%
Regime  B     response rate  96 %,  ( 95%CI ;   92%, 98%
Regime  C     response rate  94 %,  ( 95%CI ;   92%, 96%
if this is in appendix,  i would bring it forward  and  have the meta analysis of all studies transfered
to appendix  only providing  a summary of the forrest plot in  text.  That is viable only if you
have enough numbers.
3.   Figure 3 and table 3 needs to be explained more. it is important to know that many readers
may not be conversant with Network Diagrams.  i suggest that this could be explained better  e.g.,
“Figure 3  illustrates the network of studies included in our network meta-analysis, comparing
five different  regimes . The nodes represent each regime , with the size of each node
corresponding to the number of patients included in studies of that treatment. The edges between
nodes indicate direct comparisons made in at least one study, with thicker edges representing
comparisons evaluated in multiple studies. Notably, all regimes were compared directly to at
least one  regime, forming a well-connected network. However, comparisons between regime B
and  regime C  rely primarily on indirect evidence, as indicated by the thinner edge connecting
these nodes. The assessment of inconsistency showed no significant differences between direct
and indirect comparisons within this network.”
My  summary of these results would be : since YYYY several regimes  have been used for
treatment of GT2 with a   response  of  96% , 95%CI  92%, 98%   for those treated  8-12
months,.....
Regimes B and C  appeared to  demonstrate the highest response rates  compared to other regimes
(use confidence intervals)
Title: Efficacy and safety of direct-acting antiviral regimen for patients with hepatitis C virus
genotype 2: a systematic review and meta-analysis
Version: 4 Date: 25 Aug 2024
Reviewer's report:
The manuscript changes appear appropriate and acceptable.
I would suggest the following improvements
1. Noticed one typo - this can be easily corrected.  Kindly recheck your  whole document.
2. The conclusions should be clearly illustrated by the results  e.g.
Regime A     response rate  92 %,  ( 95%CI ;   90%, 94%
Regime  B     response rate  96 %,  ( 95%CI ;   92%, 98%
Regime  C     response rate  94 %,  ( 95%CI ;   92%, 96%
if this is in appendix,  i would bring it forward  and  have the meta analysis of all studies transfered
to appendix  only providing  a summary of the forrest plot in  text.  That is viable only if you
have enough numbers.
3.   Figure 3 and table 3 needs to be explained more. it is important to know that many readers
may not be conversant with Network Diagrams.  i suggest that this could be explained better  e.g.,
“Figure 3  illustrates the network of studies included in our network meta-analysis, comparing
five different  regimes . The nodes represent each regime , with the size of each node
corresponding to the number of patients included in studies of that treatment. The edges between
nodes indicate direct comparisons made in at least one study, with thicker edges representing
comparisons evaluated in multiple studies. Notably, all regimes were compared directly to at
least one  regime, forming a well-connected network. However, comparisons between regime B
and  regime C  rely primarily on indirect evidence, as indicated by the thinner edge connecting
these nodes. The assessment of inconsistency showed no significant differences between direct
and indirect comparisons within this network.”
My  summary of these results would be : since YYYY several regimes  have been used for
treatment of GT2 with a   response  of  96% , 95%CI  92%, 98%   for those treated  8-12
months,.....
Regimes B and C  appeared to  demonstrate the highest response rates  compared to other regimes
(use confidence intervals)
Please review this paper.
user
Title: Efficacy and safety of direct-acting antiviral regimen for patients with hepatitis C virus
genotype 2: a systematic review and meta-analysis
Version: 4 Date: 25 Aug 2024
Reviewer's report:
The manuscript changes appear appropriate and acceptable.
I would suggest the following improvements
1. Noticed one typo - this can be easily corrected.  Kindly recheck your  whole document.
2. The conclusions should be clearly illustrated by the results  e.g.
Regime A     response rate  92 %,  ( 95%CI ;   90%, 94%
Regime  B     response rate  96 %,  ( 95%CI ;   92%, 98%
Regime  C     response rate  94 %,  ( 95%CI ;   92%, 96%
if this is in appendix,  i would bring it forward  and  have the meta analysis of all studies transfered
to appendix  only providing  a summary of the forrest plot in  text.  That is viable only if you
have enough numbers.
3.   Figure 3 and table 3 needs to be explained more. it is important to know that many readers
may not be conversant with Network Diagrams.  i suggest that this could be explained better  e.g.,
“Figure 3  illustrates the network of studies included in our network meta-analysis, comparing
five different  regimes . The nodes represent each regime , with the size of each node
corresponding to the number of patients included in studies of that treatment. The edges between
nodes indicate direct comparisons made in at least one study, with thicker edges representing
comparisons evaluated in multiple studies. Notably, all regimes were compared directly to at
least one  regime, forming a well-connected network. However, comparisons between regime B
and  regime C  rely primarily on indirect evidence, as indicated by the thinner edge connecting
these nodes. The assessment of inconsistency showed no significant differences between direct
and indirect comparisons within this network.”
My  summary of these results would be : since YYYY several regimes  have been used for
treatment of GT2 with a   response  of  96% , 95%CI  92%, 98%   for those treated  8-12
months,.....
Regimes B and C  appeared to  demonstrate the highest response rates  compared to other regimes
(use confidence intervals)
assistant