Reviewer's report
Title:Polymorphisms of the PRLHR, HSPA12A and Risk of Gastric Cancer,
Colorectal Cancer in the Chinese Han Population
Version:2Date:1 July 2015
Reviewer: Arseniy Yuzhalin
Reviewer's report:
Su et al. performed a study analyzing the role of gene polymorphisms within the
PRLHR and HSPA12A genes and the risk of gastric and colorectal cancer.
Major compulsory revisions:
HSPs cannot be expressed on cell surface, as these are secreted proteins.
During statistical analysis, how did authors account on multiple comparisons?
Either FDR or Bonferroni correction must be included in statistical analysis in
order to do a proper comparison.
The authors should provide evidence of the functional impact of these SNPs, i.e.
if they alter protein expression levels or not. Please provide references for each
SNPs to justify the choice of these SNPs of million others polymorphisms.
The manuscript should be carefully spell checked. For example: "Tabel 1.
Demographic of gastric cancer cancers, colorectal cancers and controls",
"Genetype", etc.
Table 4 is incomplete. The authors report the analysis of 7 SNPs in 7 genes, but
table 4 contains only 2 SNPs. Also, the actual figures representing how many
patients had a particular genotype should be included (see PMID: 25213166 for
reference)
Can authors also provide information about how these SNPs correlate with
clinical features of the patients included in the analysis?
The study lacks synthesis and is pretty boring to read
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests' below
Reviewer's report
Title:Polymorphisms of the PRLHR, HSPA12A and Risk of Gastric Cancer,
Colorectal Cancer in the Chinese Han Population
Version:2Date:1 July 2015
Reviewer: Arseniy Yuzhalin
Reviewer's report:
Su et al. performed a study analyzing the role of gene polymorphisms within the
PRLHR and HSPA12A genes and the risk of gastric and colorectal cancer.
Major compulsory revisions:
HSPs cannot be expressed on cell surface, as these are secreted proteins.
During statistical analysis, how did authors account on multiple comparisons?
Either FDR or Bonferroni correction must be included in statistical analysis in
order to do a proper comparison.
The authors should provide evidence of the functional impact of these SNPs, i.e.
if they alter protein expression levels or not. Please provide references for each
SNPs to justify the choice of these SNPs of million others polymorphisms.
The manuscript should be carefully spell checked. For example: "Tabel 1.
Demographic of gastric cancer cancers, colorectal cancers and controls",
"Genetype", etc.
Table 4 is incomplete. The authors report the analysis of 7 SNPs in 7 genes, but
table 4 contains only 2 SNPs. Also, the actual figures representing how many
patients had a particular genotype should be included (see PMID: 25213166 for
reference)
Can authors also provide information about how these SNPs correlate with
clinical features of the patients included in the analysis?
The study lacks synthesis and is pretty boring to read
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests' below
Please review this paper.
user
Reviewer's report
Title:Polymorphisms of the PRLHR, HSPA12A and Risk of Gastric Cancer,
Colorectal Cancer in the Chinese Han Population
Version:2Date:1 July 2015
Reviewer: Arseniy Yuzhalin
Reviewer's report:
Su et al. performed a study analyzing the role of gene polymorphisms within the
PRLHR and HSPA12A genes and the risk of gastric and colorectal cancer.
Major compulsory revisions:
HSPs cannot be expressed on cell surface, as these are secreted proteins.
During statistical analysis, how did authors account on multiple comparisons?
Either FDR or Bonferroni correction must be included in statistical analysis in
order to do a proper comparison.
The authors should provide evidence of the functional impact of these SNPs, i.e.
if they alter protein expression levels or not. Please provide references for each
SNPs to justify the choice of these SNPs of million others polymorphisms.
The manuscript should be carefully spell checked. For example: "Tabel 1.
Demographic of gastric cancer cancers, colorectal cancers and controls",
"Genetype", etc.
Table 4 is incomplete. The authors report the analysis of 7 SNPs in 7 genes, but
table 4 contains only 2 SNPs. Also, the actual figures representing how many
patients had a particular genotype should be included (see PMID: 25213166 for
reference)
Can authors also provide information about how these SNPs correlate with
clinical features of the patients included in the analysis?
The study lacks synthesis and is pretty boring to read
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests' below
assistant