Title: Endoscopic resection for esophageal granular cell tumors: report of 62 cases
Version: 4 Date: 21 Oct 2024
Reviewer:  Ippei Tanaka
Reviewer's report:
Thank you for answering my questions in such detail. However, I believe there is one point that
should be revised, so I would like you to consider it.
In the "Intervention" section of the Methods, it is written as follows: "Three superficial
lesions originating from the mucosal muscle layer were resected by snare excision, 52 lesions
originating from the mucosal muscle or submucosal layer were resected by ESD, and seven
lesions originating from the muscularis propria layer were resected by STER." I believe this
sentence should be revised.
The reason is that the origin of the tumor from specific layers is determined by postoperative
pathological results, and it is not a factor that influences the decision-making process for
the intervention method prior to the procedure. The factors that influenced the preoperative
treatment strategy were limited to the findings of conventional endoscopy, EUS and CT.
Therefore, I believe it would be preferable to state, "In cases where EUS suggested the
lesion originated from the mucosal muscle layer, snare excision or ESD was selected, whereas
for esophageal lesions suspected to originate from the muscularis propria layer, submucosal
tunneling endoscopic resection (STER) was chosen."
Title: Endoscopic resection for esophageal granular cell tumors: report of 62 cases
Version: 4 Date: 21 Oct 2024
Reviewer:  Ippei Tanaka
Reviewer's report:
Thank you for answering my questions in such detail. However, I believe there is one point that
should be revised, so I would like you to consider it.
In the "Intervention" section of the Methods, it is written as follows: "Three superficial
lesions originating from the mucosal muscle layer were resected by snare excision, 52 lesions
originating from the mucosal muscle or submucosal layer were resected by ESD, and seven
lesions originating from the muscularis propria layer were resected by STER." I believe this
sentence should be revised.
The reason is that the origin of the tumor from specific layers is determined by postoperative
pathological results, and it is not a factor that influences the decision-making process for
the intervention method prior to the procedure. The factors that influenced the preoperative
treatment strategy were limited to the findings of conventional endoscopy, EUS and CT.
Therefore, I believe it would be preferable to state, "In cases where EUS suggested the
lesion originated from the mucosal muscle layer, snare excision or ESD was selected, whereas
for esophageal lesions suspected to originate from the muscularis propria layer, submucosal
tunneling endoscopic resection (STER) was chosen."
Please review this paper.
user
Title: Endoscopic resection for esophageal granular cell tumors: report of 62 cases
Version: 4 Date: 21 Oct 2024
Reviewer:  Ippei Tanaka
Reviewer's report:
Thank you for answering my questions in such detail. However, I believe there is one point that
should be revised, so I would like you to consider it.
In the "Intervention" section of the Methods, it is written as follows: "Three superficial
lesions originating from the mucosal muscle layer were resected by snare excision, 52 lesions
originating from the mucosal muscle or submucosal layer were resected by ESD, and seven
lesions originating from the muscularis propria layer were resected by STER." I believe this
sentence should be revised.
The reason is that the origin of the tumor from specific layers is determined by postoperative
pathological results, and it is not a factor that influences the decision-making process for
the intervention method prior to the procedure. The factors that influenced the preoperative
treatment strategy were limited to the findings of conventional endoscopy, EUS and CT.
Therefore, I believe it would be preferable to state, "In cases where EUS suggested the
lesion originated from the mucosal muscle layer, snare excision or ESD was selected, whereas
for esophageal lesions suspected to originate from the muscularis propria layer, submucosal
tunneling endoscopic resection (STER) was chosen."
assistant