Title: Association between lipid accumulation products and gallstones: an analysis of the
National Health and Nutrition Examination Survey 2017-2020
Version: 3 Date: 01 Sep 2024
Reviewer:  Toshio Tsuyuguchi
Reviewer's report:
This is a very interesting study showing a association between LAP and gallstones.
However, there are several problems.
#1. As the authors state, the presence or absence of cholelithiasis depends on the results of the
questionnaires. Some of those who responded that they did not have cholelithiasis did not have an
abdominal ultrasound or other diagnostic imaging. The quality of the study depends on whether
the subjects are receiving regular medical examinations, such as abdominal ultrasound, or
whether they are receiving appropriate medical care from their family physicians. Therefore, the
authors also need to describe the quality of health examinations and medical care as background
factors.
#2. The number of cases is considered too small to make a strong statement about the
association between LAP and gallstones, given that the data analysis was based on responses
to a questionnaire. In addition, as the authors state, it is not possible to conclude that there is
a true cause-and-effect relationship unless studies are conducted to examine the occurrence of
gallstones over time in a group of patients with high LAP.
Title: Association between lipid accumulation products and gallstones: an analysis of the
National Health and Nutrition Examination Survey 2017-2020
Version: 3 Date: 01 Sep 2024
Reviewer:  Toshio Tsuyuguchi
Reviewer's report:
This is a very interesting study showing a association between LAP and gallstones.
However, there are several problems.
#1. As the authors state, the presence or absence of cholelithiasis depends on the results of the
questionnaires. Some of those who responded that they did not have cholelithiasis did not have an
abdominal ultrasound or other diagnostic imaging. The quality of the study depends on whether
the subjects are receiving regular medical examinations, such as abdominal ultrasound, or
whether they are receiving appropriate medical care from their family physicians. Therefore, the
authors also need to describe the quality of health examinations and medical care as background
factors.
#2. The number of cases is considered too small to make a strong statement about the
association between LAP and gallstones, given that the data analysis was based on responses
to a questionnaire. In addition, as the authors state, it is not possible to conclude that there is
a true cause-and-effect relationship unless studies are conducted to examine the occurrence of
gallstones over time in a group of patients with high LAP.
Please review this paper.
user
Title: Association between lipid accumulation products and gallstones: an analysis of the
National Health and Nutrition Examination Survey 2017-2020
Version: 3 Date: 01 Sep 2024
Reviewer:  Toshio Tsuyuguchi
Reviewer's report:
This is a very interesting study showing a association between LAP and gallstones.
However, there are several problems.
#1. As the authors state, the presence or absence of cholelithiasis depends on the results of the
questionnaires. Some of those who responded that they did not have cholelithiasis did not have an
abdominal ultrasound or other diagnostic imaging. The quality of the study depends on whether
the subjects are receiving regular medical examinations, such as abdominal ultrasound, or
whether they are receiving appropriate medical care from their family physicians. Therefore, the
authors also need to describe the quality of health examinations and medical care as background
factors.
#2. The number of cases is considered too small to make a strong statement about the
association between LAP and gallstones, given that the data analysis was based on responses
to a questionnaire. In addition, as the authors state, it is not possible to conclude that there is
a true cause-and-effect relationship unless studies are conducted to examine the occurrence of
gallstones over time in a group of patients with high LAP.
assistant