Reviewer's report
Title:Altered Expression of a Putative Progenitor Cell Marker DCAMKL1 in the
Gastric Mucosa in Regeneration, Metaplasia and Dysplasia
Version: 1Date:9 March 2010
Reviewer: Edi Levi
Reviewer's report:
Reviewer’s report.
Major Compulsory Revisions.
None.
Minor essential Revisions.
None.
Discretionary Revisions.
1. This is a very interesting article demonstrating DCAMKL1 as a potential
progenitor cell marker in the gastric epithelium. The authors have made several
injury models to demonstrate the alterations in the DCAMKL1 expressing
population and nicely demonstrated that the changes seen are compatible with a
progenitor cell candidate. This is a purely descriptive study heavily based on
serial color photos. As a pathologist, I appreciated the quality of the images but
my main concern with this article is the difficulty to keep up with the explanations.
Basically this is a purely visual demonstration of changes via
immunohistochemistry. I suggest that the authors make a table or diagram or
both to summarize the changes in addition to the color photos.
2. There are other candidate progenitor cell markers available such as LGR5,
ALDH1, CD133, CD166, CD44 that have been used to demonstrate the putative
progenitor/stem cells in other areas of the gastrointestinal tract. A comparative
analysis of at least one more marker would have strengthened the study.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Altered Expression of a Putative Progenitor Cell Marker DCAMKL1 in the
Gastric Mucosa in Regeneration, Metaplasia and Dysplasia
Version: 1Date:9 March 2010
Reviewer: Edi Levi
Reviewer's report:
Reviewer’s report.
Major Compulsory Revisions.
None.
Minor essential Revisions.
None.
Discretionary Revisions.
1. This is a very interesting article demonstrating DCAMKL1 as a potential
progenitor cell marker in the gastric epithelium. The authors have made several
injury models to demonstrate the alterations in the DCAMKL1 expressing
population and nicely demonstrated that the changes seen are compatible with a
progenitor cell candidate. This is a purely descriptive study heavily based on
serial color photos. As a pathologist, I appreciated the quality of the images but
my main concern with this article is the difficulty to keep up with the explanations.
Basically this is a purely visual demonstration of changes via
immunohistochemistry. I suggest that the authors make a table or diagram or
both to summarize the changes in addition to the color photos.
2. There are other candidate progenitor cell markers available such as LGR5,
ALDH1, CD133, CD166, CD44 that have been used to demonstrate the putative
progenitor/stem cells in other areas of the gastrointestinal tract. A comparative
analysis of at least one more marker would have strengthened the study.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Altered Expression of a Putative Progenitor Cell Marker DCAMKL1 in the
Gastric Mucosa in Regeneration, Metaplasia and Dysplasia
Version: 1Date:9 March 2010
Reviewer: Edi Levi
Reviewer's report:
Reviewer’s report.
Major Compulsory Revisions.
None.
Minor essential Revisions.
None.
Discretionary Revisions.
1. This is a very interesting article demonstrating DCAMKL1 as a potential
progenitor cell marker in the gastric epithelium. The authors have made several
injury models to demonstrate the alterations in the DCAMKL1 expressing
population and nicely demonstrated that the changes seen are compatible with a
progenitor cell candidate. This is a purely descriptive study heavily based on
serial color photos. As a pathologist, I appreciated the quality of the images but
my main concern with this article is the difficulty to keep up with the explanations.
Basically this is a purely visual demonstration of changes via
immunohistochemistry. I suggest that the authors make a table or diagram or
both to summarize the changes in addition to the color photos.
2. There are other candidate progenitor cell markers available such as LGR5,
ALDH1, CD133, CD166, CD44 that have been used to demonstrate the putative
progenitor/stem cells in other areas of the gastrointestinal tract. A comparative
analysis of at least one more marker would have strengthened the study.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant