Title: Neuroendocrine Carcinoma of Esophagus: Systematic Review and Meta-analysis of Case
Series
Version: 1 Date: 03 Mar 2025
Reviewer's report:
The authors conducted a systematic review and meta-analysis of ENEC, but several areas require
further refinement:
1.How did the authors address missing data in their analysis?
2.Could the authors perform stratified analyses to investigate prognostic differences between
different pathological types of ENEC?
3.Please analyze and discuss the high heterogeneity observed in some of the results.
4.Further discussion of combined treatment strategies, particularly in locally advanced cases,
would be beneficial.
Title: Neuroendocrine Carcinoma of Esophagus: Systematic Review and Meta-analysis of Case
Series
Version: 1 Date: 03 Mar 2025
Reviewer's report:
The authors conducted a systematic review and meta-analysis of ENEC, but several areas require
further refinement:
1.How did the authors address missing data in their analysis?
2.Could the authors perform stratified analyses to investigate prognostic differences between
different pathological types of ENEC?
3.Please analyze and discuss the high heterogeneity observed in some of the results.
4.Further discussion of combined treatment strategies, particularly in locally advanced cases,
would be beneficial.
Please review this paper.
user
Title: Neuroendocrine Carcinoma of Esophagus: Systematic Review and Meta-analysis of Case
Series
Version: 1 Date: 03 Mar 2025
Reviewer's report:
The authors conducted a systematic review and meta-analysis of ENEC, but several areas require
further refinement:
1.How did the authors address missing data in their analysis?
2.Could the authors perform stratified analyses to investigate prognostic differences between
different pathological types of ENEC?
3.Please analyze and discuss the high heterogeneity observed in some of the results.
4.Further discussion of combined treatment strategies, particularly in locally advanced cases,
would be beneficial.
assistant