Title: Risk Prediction of Second Primary Malignancies in Patients after Rectal Cancer: Analysis
Based on SEER Program
Version: 2 Date: 07 Aug 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
In this retrospective study, the authors presented the second primary malignancy (SPM)risk
factor in rectal cancer using the data from the SEER program. The author found that age and N
factor are essential factors for OS. There are several articles on other sites on the malignancy
of SPM in the SEER program. However, there is no research on rectal cancer of SPM. For this
reason, the article is worth publishing.
1. Please add the demographic and clinicopathological characteristics of the second primary
malignancies as one Table.
2. Please add the section on the definition of SPM for rectal cancer.
3. In the limitations, the authors should add bias using any chemotherapy used in this study.
Title: Risk Prediction of Second Primary Malignancies in Patients after Rectal Cancer: Analysis
Based on SEER Program
Version: 2 Date: 07 Aug 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
In this retrospective study, the authors presented the second primary malignancy (SPM)risk
factor in rectal cancer using the data from the SEER program. The author found that age and N
factor are essential factors for OS. There are several articles on other sites on the malignancy
of SPM in the SEER program. However, there is no research on rectal cancer of SPM. For this
reason, the article is worth publishing.
1. Please add the demographic and clinicopathological characteristics of the second primary
malignancies as one Table.
2. Please add the section on the definition of SPM for rectal cancer.
3. In the limitations, the authors should add bias using any chemotherapy used in this study.
Please review this paper.
user
Title: Risk Prediction of Second Primary Malignancies in Patients after Rectal Cancer: Analysis
Based on SEER Program
Version: 2 Date: 07 Aug 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
In this retrospective study, the authors presented the second primary malignancy (SPM)risk
factor in rectal cancer using the data from the SEER program. The author found that age and N
factor are essential factors for OS. There are several articles on other sites on the malignancy
of SPM in the SEER program. However, there is no research on rectal cancer of SPM. For this
reason, the article is worth publishing.
1. Please add the demographic and clinicopathological characteristics of the second primary
malignancies as one Table.
2. Please add the section on the definition of SPM for rectal cancer.
3. In the limitations, the authors should add bias using any chemotherapy used in this study.
assistant