Reviewer's report
Title:Influence of laparoscopic-assisted gastrectomy and open gastrectomy on
serum interleukin-6 levels in patients with gastric cancer among Asian
populations
Version:3Date:13 January 2015
Reviewer: Toru Aoyama
Reviewer's report:
The authors reviewed and evaluated the influence of laparoscopic-assisted
gastrectomy (LAG) and open gastrectomy (OG) on serum interleukin-6 (IL-6)
levels in patients with gastric cancer (GC) among Asian populations. The paper
is well written but there are some points to be clarified.
Major comments
1: It is unclear the inclusion and exclusion criteria. The authors need to show the
details of the inclusion and exclusion criteria of the present study.
2: Why the authors only focused the IL-6 to evaluate the influence of LAG and
open OG. Is IL-6 optimal marker to evaluate the surgical stress? More other
cytokines and hormones, such as IL-1, TNF, IFN-c, catecholamine, and
corticosteroids, also are related to surgical stress. How about were these
cytokines or hormones?
3: Was the IL-6 measured same points? If not, it is possible that the level of
surgical stress was not accurately evaluated.
4: The authors should show the patients background. IL-6 might be affected the
patients background.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:Influence of laparoscopic-assisted gastrectomy and open gastrectomy on
serum interleukin-6 levels in patients with gastric cancer among Asian
populations
Version:3Date:13 January 2015
Reviewer: Toru Aoyama
Reviewer's report:
The authors reviewed and evaluated the influence of laparoscopic-assisted
gastrectomy (LAG) and open gastrectomy (OG) on serum interleukin-6 (IL-6)
levels in patients with gastric cancer (GC) among Asian populations. The paper
is well written but there are some points to be clarified.
Major comments
1: It is unclear the inclusion and exclusion criteria. The authors need to show the
details of the inclusion and exclusion criteria of the present study.
2: Why the authors only focused the IL-6 to evaluate the influence of LAG and
open OG. Is IL-6 optimal marker to evaluate the surgical stress? More other
cytokines and hormones, such as IL-1, TNF, IFN-c, catecholamine, and
corticosteroids, also are related to surgical stress. How about were these
cytokines or hormones?
3: Was the IL-6 measured same points? If not, it is possible that the level of
surgical stress was not accurately evaluated.
4: The authors should show the patients background. IL-6 might be affected the
patients background.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:Influence of laparoscopic-assisted gastrectomy and open gastrectomy on
serum interleukin-6 levels in patients with gastric cancer among Asian
populations
Version:3Date:13 January 2015
Reviewer: Toru Aoyama
Reviewer's report:
The authors reviewed and evaluated the influence of laparoscopic-assisted
gastrectomy (LAG) and open gastrectomy (OG) on serum interleukin-6 (IL-6)
levels in patients with gastric cancer (GC) among Asian populations. The paper
is well written but there are some points to be clarified.
Major comments
1: It is unclear the inclusion and exclusion criteria. The authors need to show the
details of the inclusion and exclusion criteria of the present study.
2: Why the authors only focused the IL-6 to evaluate the influence of LAG and
open OG. Is IL-6 optimal marker to evaluate the surgical stress? More other
cytokines and hormones, such as IL-1, TNF, IFN-c, catecholamine, and
corticosteroids, also are related to surgical stress. How about were these
cytokines or hormones?
3: Was the IL-6 measured same points? If not, it is possible that the level of
surgical stress was not accurately evaluated.
4: The authors should show the patients background. IL-6 might be affected the
patients background.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant