Reviewer ’s report  
 
Title: Influence of cirrhosis on long -term prognosis after surgery in patients with combined 
hepatocellular -cholangiocarcinoma  
 
Version: 0 Date: 19 Dec 2016  
Reviewer: Alisan Kahraman  
Reviewer's report:  
The authors may address  the following questions:  
1. Patients with and without liver cirrhosis were predomi nantly of male gender. What is the 
explanation for this gender distribution?  
2. Total bilirubin is extremely  high in patients without liver cirrhosis with 15.4 µmol/L. Is this 
correct? One would expect lower bilirubin -levels in non -cirrhotic patients.  
3. Did the authors determine CEA -levels ? AFP and CA 19 -9 were investigated.  
4. Did the authors investigated if high BMI or presence of diabetes had any influence on course 
of the patients?  
Are t he methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional st atistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or  lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future ? 
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the  authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Common s 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open pe er review policy of the journal  
Reviewer ’s report  
 
Title: Influence of cirrhosis on long -term prognosis after surgery in patients with combined 
hepatocellular -cholangiocarcinoma  
 
Version: 0 Date: 19 Dec 2016  
Reviewer: Alisan Kahraman  
Reviewer's report:  
The authors may address  the following questions:  
1. Patients with and without liver cirrhosis were predomi nantly of male gender. What is the 
explanation for this gender distribution?  
2. Total bilirubin is extremely  high in patients without liver cirrhosis with 15.4 µmol/L. Is this 
correct? One would expect lower bilirubin -levels in non -cirrhotic patients.  
3. Did the authors determine CEA -levels ? AFP and CA 19 -9 were investigated.  
4. Did the authors investigated if high BMI or presence of diabetes had any influence on course 
of the patients?  
Are t he methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional st atistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or  lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future ? 
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the  authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Common s 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open pe er review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Influence of cirrhosis on long -term prognosis after surgery in patients with combined 
hepatocellular -cholangiocarcinoma  
 
Version: 0 Date: 19 Dec 2016  
Reviewer: Alisan Kahraman  
Reviewer's report:  
The authors may address  the following questions:  
1. Patients with and without liver cirrhosis were predomi nantly of male gender. What is the 
explanation for this gender distribution?  
2. Total bilirubin is extremely  high in patients without liver cirrhosis with 15.4 µmol/L. Is this 
correct? One would expect lower bilirubin -levels in non -cirrhotic patients.  
3. Did the authors determine CEA -levels ? AFP and CA 19 -9 were investigated.  
4. Did the authors investigated if high BMI or presence of diabetes had any influence on course 
of the patients?  
Are t he methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional st atistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or  lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future ? 
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I  declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the  authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Common s 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open pe er review policy of the journal  
assistant