Reviewer's report
Title:Systemic lupus erythematosus complicated by Crohn's disease: a case
report and literature review
Version: 2Date:5 October 2012
Reviewer: Gottfried Novacek
Reviewer's report:
This is an interesting report of a patient with systemic lupus erythematosus (SLE)
and crohn colitis. She suffered from gastrointestinal bleeding and diarrhea.
Findings at colonoscpy as well as histopathological changes led to the diagnosis
of Crohn's disease. The patient responded well to infliximab.
Major Compulsory Revision
1) Case presentation/last paragraph: The authors should describe the dosage of
infliximab and the intervals between the infusions, the observation period after
the start of infliximab, if their was a loss of response, and more objective
parameters for treatment response such as CRP and HBI or CDAI.
Discretionary Revisions
1) Case presentation/1st paragraph: In which parts of colon were the ulcers
located? Was the terminal ileum investigated and what was it look like? This
questions should be answered for all mentioned colonoscopies.
2) Case presentation/1st paragraph: The patient received prednisolone for a very
long time. Why was cyclophosphamide never given to the patient?
3) Discussion/8. paragraph: I suggest to change the 2nd sentence: However,
longterm treatment with glucocorticosteroids should be avoided. In case of
steroid dependency or steroid refractory TNF-alpha blockers are an effective
treatment to induce and maintain remission.
4) Discussion: The authors should discuss the knowledge about the
effectiveness of infliximab for SLE and especially gastrointestinal symptoms
caused by SLE. The authors describe that TNF-alpha blockers can cause
drug-induced lupus, but can they also improve SLE?
5) References: The following reference should be included in the list: Katsanos
KH, et al. JCC 2012;6:735-42.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests' below.
Reviewer's report
Title:Systemic lupus erythematosus complicated by Crohn's disease: a case
report and literature review
Version: 2Date:5 October 2012
Reviewer: Gottfried Novacek
Reviewer's report:
This is an interesting report of a patient with systemic lupus erythematosus (SLE)
and crohn colitis. She suffered from gastrointestinal bleeding and diarrhea.
Findings at colonoscpy as well as histopathological changes led to the diagnosis
of Crohn's disease. The patient responded well to infliximab.
Major Compulsory Revision
1) Case presentation/last paragraph: The authors should describe the dosage of
infliximab and the intervals between the infusions, the observation period after
the start of infliximab, if their was a loss of response, and more objective
parameters for treatment response such as CRP and HBI or CDAI.
Discretionary Revisions
1) Case presentation/1st paragraph: In which parts of colon were the ulcers
located? Was the terminal ileum investigated and what was it look like? This
questions should be answered for all mentioned colonoscopies.
2) Case presentation/1st paragraph: The patient received prednisolone for a very
long time. Why was cyclophosphamide never given to the patient?
3) Discussion/8. paragraph: I suggest to change the 2nd sentence: However,
longterm treatment with glucocorticosteroids should be avoided. In case of
steroid dependency or steroid refractory TNF-alpha blockers are an effective
treatment to induce and maintain remission.
4) Discussion: The authors should discuss the knowledge about the
effectiveness of infliximab for SLE and especially gastrointestinal symptoms
caused by SLE. The authors describe that TNF-alpha blockers can cause
drug-induced lupus, but can they also improve SLE?
5) References: The following reference should be included in the list: Katsanos
KH, et al. JCC 2012;6:735-42.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests' below.
Please review this paper.
user
Reviewer's report
Title:Systemic lupus erythematosus complicated by Crohn's disease: a case
report and literature review
Version: 2Date:5 October 2012
Reviewer: Gottfried Novacek
Reviewer's report:
This is an interesting report of a patient with systemic lupus erythematosus (SLE)
and crohn colitis. She suffered from gastrointestinal bleeding and diarrhea.
Findings at colonoscpy as well as histopathological changes led to the diagnosis
of Crohn's disease. The patient responded well to infliximab.
Major Compulsory Revision
1) Case presentation/last paragraph: The authors should describe the dosage of
infliximab and the intervals between the infusions, the observation period after
the start of infliximab, if their was a loss of response, and more objective
parameters for treatment response such as CRP and HBI or CDAI.
Discretionary Revisions
1) Case presentation/1st paragraph: In which parts of colon were the ulcers
located? Was the terminal ileum investigated and what was it look like? This
questions should be answered for all mentioned colonoscopies.
2) Case presentation/1st paragraph: The patient received prednisolone for a very
long time. Why was cyclophosphamide never given to the patient?
3) Discussion/8. paragraph: I suggest to change the 2nd sentence: However,
longterm treatment with glucocorticosteroids should be avoided. In case of
steroid dependency or steroid refractory TNF-alpha blockers are an effective
treatment to induce and maintain remission.
4) Discussion: The authors should discuss the knowledge about the
effectiveness of infliximab for SLE and especially gastrointestinal symptoms
caused by SLE. The authors describe that TNF-alpha blockers can cause
drug-induced lupus, but can they also improve SLE?
5) References: The following reference should be included in the list: Katsanos
KH, et al. JCC 2012;6:735-42.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests' below.
assistant