Title: Relationship between anthropometric measures and the risk of incident Metabolic
dysfunction-associated steatotic liver disease: a longitudinal study
Version: 2 Date: 21 Jan 2025
Reviewer's report:
The aim of this study was to investigate the association of body roundness index (BRI) and body
shape index (ABSI) with the occurrence of metabolic dysfunction-associated steatohepatopathy
(MASLD) in comparison with traditional waist circumference (WC) and body mass index
(BMI). The study evaluated the association of different anthropometric measures with the
development of MASLD by retrospectively analysing data from the Japanese Health Screening
Programme, and found that BMI was most significantly associated with MASLD, especially
in men, and provided the strongest predictive value for MASLD diagnosis. The study also
highlighted the need to develop specific waist circumference standards for Asian populations to
improve the diagnosis of MASLD. This study provides valuable data for exploring the use of new
body shape measures (BRI and ABSI) in metabolic dysfunction-associated steatohepatopathy
(MASLD), and in particular makes meaningful explorations in analysing gender differences.
Despite the limitations of retrospective and confounder control in the study design, its innovative
nature and potential contribution to clinical practice make it of academic value. Future studies
could further overcome these limitations and validate the clinical utility of these new metrics.
Based on the authors' responses and revisions to the five review comments, the manuscript's
deficiencies were largely addressed.
Title: Relationship between anthropometric measures and the risk of incident Metabolic
dysfunction-associated steatotic liver disease: a longitudinal study
Version: 2 Date: 21 Jan 2025
Reviewer's report:
The aim of this study was to investigate the association of body roundness index (BRI) and body
shape index (ABSI) with the occurrence of metabolic dysfunction-associated steatohepatopathy
(MASLD) in comparison with traditional waist circumference (WC) and body mass index
(BMI). The study evaluated the association of different anthropometric measures with the
development of MASLD by retrospectively analysing data from the Japanese Health Screening
Programme, and found that BMI was most significantly associated with MASLD, especially
in men, and provided the strongest predictive value for MASLD diagnosis. The study also
highlighted the need to develop specific waist circumference standards for Asian populations to
improve the diagnosis of MASLD. This study provides valuable data for exploring the use of new
body shape measures (BRI and ABSI) in metabolic dysfunction-associated steatohepatopathy
(MASLD), and in particular makes meaningful explorations in analysing gender differences.
Despite the limitations of retrospective and confounder control in the study design, its innovative
nature and potential contribution to clinical practice make it of academic value. Future studies
could further overcome these limitations and validate the clinical utility of these new metrics.
Based on the authors' responses and revisions to the five review comments, the manuscript's
deficiencies were largely addressed.
Please review this paper.
user
Title: Relationship between anthropometric measures and the risk of incident Metabolic
dysfunction-associated steatotic liver disease: a longitudinal study
Version: 2 Date: 21 Jan 2025
Reviewer's report:
The aim of this study was to investigate the association of body roundness index (BRI) and body
shape index (ABSI) with the occurrence of metabolic dysfunction-associated steatohepatopathy
(MASLD) in comparison with traditional waist circumference (WC) and body mass index
(BMI). The study evaluated the association of different anthropometric measures with the
development of MASLD by retrospectively analysing data from the Japanese Health Screening
Programme, and found that BMI was most significantly associated with MASLD, especially
in men, and provided the strongest predictive value for MASLD diagnosis. The study also
highlighted the need to develop specific waist circumference standards for Asian populations to
improve the diagnosis of MASLD. This study provides valuable data for exploring the use of new
body shape measures (BRI and ABSI) in metabolic dysfunction-associated steatohepatopathy
(MASLD), and in particular makes meaningful explorations in analysing gender differences.
Despite the limitations of retrospective and confounder control in the study design, its innovative
nature and potential contribution to clinical practice make it of academic value. Future studies
could further overcome these limitations and validate the clinical utility of these new metrics.
Based on the authors' responses and revisions to the five review comments, the manuscript's
deficiencies were largely addressed.
assistant