Title: Sex- and reproductive status-specific relationships between body composition and non-
alcoholic fatty liver disease
Version: 1 Date: 11 May 2023
Reviewer:  Honglu Yu
Reviewer's report:
The clinical significance of this article is limited. The authors said “WC has added value as
a more routine and simple measurement for the identification of NAFLD in men, and fat loss
and muscle gain are important strategies for the management of NAFLD in men. For post-
menopausal women, the important thing is to reduce visceral fat”. In clinical management,
the ways to change these data are all exercising, losing weight and controlling diets. How to
specifically manage patients with NAFLD in different gender and reproductive status.
In the Methods part of the Abstract section, the indicators measured by using FibroScan and
BIA should be given.
Because the authors used surrogate markers evaluating NAFLD severity, the study results may
be questioned.
In the Introduction section, the sentence “Therefore, NAFLD, gender and reproductive status,
and body composition are all interrelated and influence each other” is wrong, where the word
“influence” should be revised as “influenced”.
In the Study design and population part of the Patients and methods section, the name of the
hospital that conducted the study should be consistent with the hospital that the study approved
by the Ethics Committees.
In the Liver steatosis and fibrosis measurement part of the Patients and methods section,
the sentence “The measurement results were considered reliable when… was <30%” is
inconsistent with the reference 12 described that “The manufacturer recommends that successful
measurements be validated by using the following three criteria.
In the Body composition measurement part of the Patients and methods section, the sentence
“Visceral obesity was defined as VFA # 100 cm² in both genders” lacks references.
In the Collection of other clinical data part of the Patients and methods section, the authors said
“Only laboratory data obtained within 1 month of the FibroScan test were considered valid”.
How do the authors decide the time as “within 1 month”?
In the Table S2, the unit of “Age” should be revised as “years”.
The values of “ALT”, “AST”, “AKP”, and “GGT” are incredible. Clinically, these values are
generally decimals rather than integers.
What is the meaning of “E”?
The authors should check the position of the inserted references throughout this article. The
inserted references should be placed before periods.
Title: Sex- and reproductive status-specific relationships between body composition and non-
alcoholic fatty liver disease
Version: 1 Date: 11 May 2023
Reviewer:  Honglu Yu
Reviewer's report:
The clinical significance of this article is limited. The authors said “WC has added value as
a more routine and simple measurement for the identification of NAFLD in men, and fat loss
and muscle gain are important strategies for the management of NAFLD in men. For post-
menopausal women, the important thing is to reduce visceral fat”. In clinical management,
the ways to change these data are all exercising, losing weight and controlling diets. How to
specifically manage patients with NAFLD in different gender and reproductive status.
In the Methods part of the Abstract section, the indicators measured by using FibroScan and
BIA should be given.
Because the authors used surrogate markers evaluating NAFLD severity, the study results may
be questioned.
In the Introduction section, the sentence “Therefore, NAFLD, gender and reproductive status,
and body composition are all interrelated and influence each other” is wrong, where the word
“influence” should be revised as “influenced”.
In the Study design and population part of the Patients and methods section, the name of the
hospital that conducted the study should be consistent with the hospital that the study approved
by the Ethics Committees.
In the Liver steatosis and fibrosis measurement part of the Patients and methods section,
the sentence “The measurement results were considered reliable when… was <30%” is
inconsistent with the reference 12 described that “The manufacturer recommends that successful
measurements be validated by using the following three criteria.
In the Body composition measurement part of the Patients and methods section, the sentence
“Visceral obesity was defined as VFA # 100 cm² in both genders” lacks references.
In the Collection of other clinical data part of the Patients and methods section, the authors said
“Only laboratory data obtained within 1 month of the FibroScan test were considered valid”.
How do the authors decide the time as “within 1 month”?
In the Table S2, the unit of “Age” should be revised as “years”.
The values of “ALT”, “AST”, “AKP”, and “GGT” are incredible. Clinically, these values are
generally decimals rather than integers.
What is the meaning of “E”?
The authors should check the position of the inserted references throughout this article. The
inserted references should be placed before periods.
Please review this paper.
user
Title: Sex- and reproductive status-specific relationships between body composition and non-
alcoholic fatty liver disease
Version: 1 Date: 11 May 2023
Reviewer:  Honglu Yu
Reviewer's report:
The clinical significance of this article is limited. The authors said “WC has added value as
a more routine and simple measurement for the identification of NAFLD in men, and fat loss
and muscle gain are important strategies for the management of NAFLD in men. For post-
menopausal women, the important thing is to reduce visceral fat”. In clinical management,
the ways to change these data are all exercising, losing weight and controlling diets. How to
specifically manage patients with NAFLD in different gender and reproductive status.
In the Methods part of the Abstract section, the indicators measured by using FibroScan and
BIA should be given.
Because the authors used surrogate markers evaluating NAFLD severity, the study results may
be questioned.
In the Introduction section, the sentence “Therefore, NAFLD, gender and reproductive status,
and body composition are all interrelated and influence each other” is wrong, where the word
“influence” should be revised as “influenced”.
In the Study design and population part of the Patients and methods section, the name of the
hospital that conducted the study should be consistent with the hospital that the study approved
by the Ethics Committees.
In the Liver steatosis and fibrosis measurement part of the Patients and methods section,
the sentence “The measurement results were considered reliable when… was <30%” is
inconsistent with the reference 12 described that “The manufacturer recommends that successful
measurements be validated by using the following three criteria.
In the Body composition measurement part of the Patients and methods section, the sentence
“Visceral obesity was defined as VFA # 100 cm² in both genders” lacks references.
In the Collection of other clinical data part of the Patients and methods section, the authors said
“Only laboratory data obtained within 1 month of the FibroScan test were considered valid”.
How do the authors decide the time as “within 1 month”?
In the Table S2, the unit of “Age” should be revised as “years”.
The values of “ALT”, “AST”, “AKP”, and “GGT” are incredible. Clinically, these values are
generally decimals rather than integers.
What is the meaning of “E”?
The authors should check the position of the inserted references throughout this article. The
inserted references should be placed before periods.
assistant