Title: Mesenteric Fat Proliferation on Magnetic Resonance Enterography Is a Predictor of Long-
Term Disease Complications in Crohn’s Disease
Version: 4 Date: 21 May 2025
Reviewer's report:
Important topic.
Questions / Suggestions:
-would be helpful to add indications for surgery - obstruction, penetrating disease, medially
refractory disease, etc...
-any difference in results between patients with and without previous IBD surgery?
- what was stricture criteria - CONSTRICT?
- was Radiologist blinded to all clinical information?
- Would make it clear that MRE findings in the study refer to the index MRE (not follow-up
imaging)
- Did all the patients on index MRE with stricture (14.3%) also have mesenteric fat proliferation?
-What percent of those with mesenteric fat proliferation on index MRE developed strictures or
penetrating complication on follow-up imaging?
Title: Mesenteric Fat Proliferation on Magnetic Resonance Enterography Is a Predictor of Long-
Term Disease Complications in Crohn’s Disease
Version: 4 Date: 21 May 2025
Reviewer's report:
Important topic.
Questions / Suggestions:
-would be helpful to add indications for surgery - obstruction, penetrating disease, medially
refractory disease, etc...
-any difference in results between patients with and without previous IBD surgery?
- what was stricture criteria - CONSTRICT?
- was Radiologist blinded to all clinical information?
- Would make it clear that MRE findings in the study refer to the index MRE (not follow-up
imaging)
- Did all the patients on index MRE with stricture (14.3%) also have mesenteric fat proliferation?
-What percent of those with mesenteric fat proliferation on index MRE developed strictures or
penetrating complication on follow-up imaging?
Please review this paper.
user
Title: Mesenteric Fat Proliferation on Magnetic Resonance Enterography Is a Predictor of Long-
Term Disease Complications in Crohn’s Disease
Version: 4 Date: 21 May 2025
Reviewer's report:
Important topic.
Questions / Suggestions:
-would be helpful to add indications for surgery - obstruction, penetrating disease, medially
refractory disease, etc...
-any difference in results between patients with and without previous IBD surgery?
- what was stricture criteria - CONSTRICT?
- was Radiologist blinded to all clinical information?
- Would make it clear that MRE findings in the study refer to the index MRE (not follow-up
imaging)
- Did all the patients on index MRE with stricture (14.3%) also have mesenteric fat proliferation?
-What percent of those with mesenteric fat proliferation on index MRE developed strictures or
penetrating complication on follow-up imaging?
assistant