Reviewer's report
Title:Study of the effects of antivirus therapy in patients with chronic liver
disease due to hepatitis C virus infection
Version: 1Date:14 June 2012
Reviewer: Irfan Ahmad
Reviewer's report:
In the manuscript of Mustafa et al. entitled Study of the effects of antivirus
therapy in patients with chronic liver disease due to hepatitis C virus infection, the
authors have put an interesting effort to monitor the effect of the gold standard
therapy for the treatment of hepatitis C patients. However I feel some
points/issues can be clarified before it is published.
Major Compulsory Revisions
From Table 2, It seems ALT level in Non res-ponders is low as compare to other
groups before treatment. Is it statistically significant? if yes then what is the
impact of this finding on the consideration to start gold standard therapy to
Hepatitis C patients.
Discretionary Revisions
Authors did not describe the Genotype of Hepatitits C in patients group. Is there
any correlation between Genotype of Hepatitis C virus and response of combined
gold therapy?
Authors did not mention the Hcy levels during the treatment. It could be
interesting to see patent response of hcy during the therapy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Study of the effects of antivirus therapy in patients with chronic liver
disease due to hepatitis C virus infection
Version: 1Date:14 June 2012
Reviewer: Irfan Ahmad
Reviewer's report:
In the manuscript of Mustafa et al. entitled Study of the effects of antivirus
therapy in patients with chronic liver disease due to hepatitis C virus infection, the
authors have put an interesting effort to monitor the effect of the gold standard
therapy for the treatment of hepatitis C patients. However I feel some
points/issues can be clarified before it is published.
Major Compulsory Revisions
From Table 2, It seems ALT level in Non res-ponders is low as compare to other
groups before treatment. Is it statistically significant? if yes then what is the
impact of this finding on the consideration to start gold standard therapy to
Hepatitis C patients.
Discretionary Revisions
Authors did not describe the Genotype of Hepatitits C in patients group. Is there
any correlation between Genotype of Hepatitis C virus and response of combined
gold therapy?
Authors did not mention the Hcy levels during the treatment. It could be
interesting to see patent response of hcy during the therapy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Study of the effects of antivirus therapy in patients with chronic liver
disease due to hepatitis C virus infection
Version: 1Date:14 June 2012
Reviewer: Irfan Ahmad
Reviewer's report:
In the manuscript of Mustafa et al. entitled Study of the effects of antivirus
therapy in patients with chronic liver disease due to hepatitis C virus infection, the
authors have put an interesting effort to monitor the effect of the gold standard
therapy for the treatment of hepatitis C patients. However I feel some
points/issues can be clarified before it is published.
Major Compulsory Revisions
From Table 2, It seems ALT level in Non res-ponders is low as compare to other
groups before treatment. Is it statistically significant? if yes then what is the
impact of this finding on the consideration to start gold standard therapy to
Hepatitis C patients.
Discretionary Revisions
Authors did not describe the Genotype of Hepatitits C in patients group. Is there
any correlation between Genotype of Hepatitis C virus and response of combined
gold therapy?
Authors did not mention the Hcy levels during the treatment. It could be
interesting to see patent response of hcy during the therapy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
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