Title: Renal and bone side effects of long-term use of entecavir, tenofovir disoproxil fumarate,
and tenofovir alafenamide fumarate in patients with hepatitis B: A network meta-analysis
Version: 1 Date: 10 Jun 2023
Reviewer's report:
The article by Z. Liu et al is a meta-analysis of studies comapring TDF, TAF and ENT regarding
the side effects.
The authors concluded that TDF has the weaker side effects profile on kindeys and bones
compared to ENT or TAF.
The article did not add anything in the existing literature. The conclusion and suggestions by
authors in the last paragraph of discussion is included in EASL guidelines several years before.
In order to have the article improve the authors should add information regarding time of follow
up and use only studies with longer FU or make a comparison between studies with short or
long FU. In addition safety in pts with advanced liver disease may add something new.
Age is also an important issue.
Title: Renal and bone side effects of long-term use of entecavir, tenofovir disoproxil fumarate,
and tenofovir alafenamide fumarate in patients with hepatitis B: A network meta-analysis
Version: 1 Date: 10 Jun 2023
Reviewer's report:
The article by Z. Liu et al is a meta-analysis of studies comapring TDF, TAF and ENT regarding
the side effects.
The authors concluded that TDF has the weaker side effects profile on kindeys and bones
compared to ENT or TAF.
The article did not add anything in the existing literature. The conclusion and suggestions by
authors in the last paragraph of discussion is included in EASL guidelines several years before.
In order to have the article improve the authors should add information regarding time of follow
up and use only studies with longer FU or make a comparison between studies with short or
long FU. In addition safety in pts with advanced liver disease may add something new.
Age is also an important issue.
Please review this paper.
user
Title: Renal and bone side effects of long-term use of entecavir, tenofovir disoproxil fumarate,
and tenofovir alafenamide fumarate in patients with hepatitis B: A network meta-analysis
Version: 1 Date: 10 Jun 2023
Reviewer's report:
The article by Z. Liu et al is a meta-analysis of studies comapring TDF, TAF and ENT regarding
the side effects.
The authors concluded that TDF has the weaker side effects profile on kindeys and bones
compared to ENT or TAF.
The article did not add anything in the existing literature. The conclusion and suggestions by
authors in the last paragraph of discussion is included in EASL guidelines several years before.
In order to have the article improve the authors should add information regarding time of follow
up and use only studies with longer FU or make a comparison between studies with short or
long FU. In addition safety in pts with advanced liver disease may add something new.
Age is also an important issue.
assistant