Reviewer's report
Title:Increasing late stage and mortality of colorectal cancer demonstrates the
need for screening: a population based study in Ireland, 1994-2010.
Version:2Date:3 March 2014
Reviewer: Jan Willem J.W.W Coebergh
Reviewer's report:
My comment
I am confused by this article,
How can survival improve so strongly (without explanation, e.g. more adjuvant
therapy, by better staging (i.e. higher % of positive nodes) but that is not shown?
While the proportion of stage III and IV increased>Is it a good idea to t
Might an alternative explanation be that the rate and proportion of pT1 and pT2
declined, because there was (much) more opportunistic screening ?
In most countries we see an increase of incidence in males (see Arnold paper)
Why is the paper of Arnold et al. Not referred ton coming from the DREG ECO
website ?
In fact autors are trying to measure progress against colorectal cancer and
whether screening can add to progress. Most likely given the very high incidence
rates in Ireland 1990-2007
I would also advise to look at 2 trend papers of incidence, mortality and survival
by
- van Steenbergen et al. For colon carcinoma
- and Elferink et al. for rectal carcinoma published in 2010
Why don’t we see a figure with incidence and mortality trend for males and
females in Ireland?
Reviewer's report
Title:Increasing late stage and mortality of colorectal cancer demonstrates the
need for screening: a population based study in Ireland, 1994-2010.
Version:2Date:3 March 2014
Reviewer: Jan Willem J.W.W Coebergh
Reviewer's report:
My comment
I am confused by this article,
How can survival improve so strongly (without explanation, e.g. more adjuvant
therapy, by better staging (i.e. higher % of positive nodes) but that is not shown?
While the proportion of stage III and IV increased>Is it a good idea to t
Might an alternative explanation be that the rate and proportion of pT1 and pT2
declined, because there was (much) more opportunistic screening ?
In most countries we see an increase of incidence in males (see Arnold paper)
Why is the paper of Arnold et al. Not referred ton coming from the DREG ECO
website ?
In fact autors are trying to measure progress against colorectal cancer and
whether screening can add to progress. Most likely given the very high incidence
rates in Ireland 1990-2007
I would also advise to look at 2 trend papers of incidence, mortality and survival
by
- van Steenbergen et al. For colon carcinoma
- and Elferink et al. for rectal carcinoma published in 2010
Why don’t we see a figure with incidence and mortality trend for males and
females in Ireland?
Please review this paper.
user
Reviewer's report
Title:Increasing late stage and mortality of colorectal cancer demonstrates the
need for screening: a population based study in Ireland, 1994-2010.
Version:2Date:3 March 2014
Reviewer: Jan Willem J.W.W Coebergh
Reviewer's report:
My comment
I am confused by this article,
How can survival improve so strongly (without explanation, e.g. more adjuvant
therapy, by better staging (i.e. higher % of positive nodes) but that is not shown?
While the proportion of stage III and IV increased>Is it a good idea to t
Might an alternative explanation be that the rate and proportion of pT1 and pT2
declined, because there was (much) more opportunistic screening ?
In most countries we see an increase of incidence in males (see Arnold paper)
Why is the paper of Arnold et al. Not referred ton coming from the DREG ECO
website ?
In fact autors are trying to measure progress against colorectal cancer and
whether screening can add to progress. Most likely given the very high incidence
rates in Ireland 1990-2007
I would also advise to look at 2 trend papers of incidence, mortality and survival
by
- van Steenbergen et al. For colon carcinoma
- and Elferink et al. for rectal carcinoma published in 2010
Why don’t we see a figure with incidence and mortality trend for males and
females in Ireland?
assistant