Reviewer's report
Title:New PRSS1 and common CFTR mutations in a child with acute recurrent
pancreatitis, could be considered an "Hereditary" form of pancreatitis ?
Version: 1Date:17 March 2010
Reviewer: Atsushi Masamune
Reviewer's report:
Major Compulsory Revisions (which the author must respond to before a
decision on publication can be reached)
This is a well-written paper describing a novel PRSS1 polymorphism, co-existing
with a well-known CFTR mutation, in a patient with recurrent acute pancreatitis.
But, this report deals with a single case report, and the role of the novel PRSS1
mutation remains unknown in the absence of functional study. Because the
patient carries the F508del CFTR mutation, it is likely that the mechanism
underlying the recurrent episodes of acute pancreatitis might be due to the
presence of the CFTR mutation.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:New PRSS1 and common CFTR mutations in a child with acute recurrent
pancreatitis, could be considered an "Hereditary" form of pancreatitis ?
Version: 1Date:17 March 2010
Reviewer: Atsushi Masamune
Reviewer's report:
Major Compulsory Revisions (which the author must respond to before a
decision on publication can be reached)
This is a well-written paper describing a novel PRSS1 polymorphism, co-existing
with a well-known CFTR mutation, in a patient with recurrent acute pancreatitis.
But, this report deals with a single case report, and the role of the novel PRSS1
mutation remains unknown in the absence of functional study. Because the
patient carries the F508del CFTR mutation, it is likely that the mechanism
underlying the recurrent episodes of acute pancreatitis might be due to the
presence of the CFTR mutation.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:New PRSS1 and common CFTR mutations in a child with acute recurrent
pancreatitis, could be considered an "Hereditary" form of pancreatitis ?
Version: 1Date:17 March 2010
Reviewer: Atsushi Masamune
Reviewer's report:
Major Compulsory Revisions (which the author must respond to before a
decision on publication can be reached)
This is a well-written paper describing a novel PRSS1 polymorphism, co-existing
with a well-known CFTR mutation, in a patient with recurrent acute pancreatitis.
But, this report deals with a single case report, and the role of the novel PRSS1
mutation remains unknown in the absence of functional study. Because the
patient carries the F508del CFTR mutation, it is likely that the mechanism
underlying the recurrent episodes of acute pancreatitis might be due to the
presence of the CFTR mutation.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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