Title: Preoperative CT Lymph Node Size as a Predictor of Nodal Metastasis in Resectable Colon
Cancer: A Retrospective Study of 694 Patients
Version: 2 Date: 10 Dec 2024
Reviewer's report:
1.
The measurements of lymph node size mentioned in the article were performed by an
experienced surgical oncologist, but were measures taken to evaluate and ensure consistency
and repeatability of the measurements? Was a blind test conducted by a second independent
evaluator to verify these measurements?
2.
How can I ensure that the lymph nodes measured on CT images are consistent with the lymph
nodes in the pathology report? Is it possible that some lymph nodes were missed on CT, or that
all metastatic lymph nodes were not identified in the pathology report?
3.
Did the paper consider building a predictive model that included other clinical and pathological
parameters besides lymph node size? For example, were tumor T-stage, patient BMI, tumor
location, etc. included in the model, and how did they affect model performance?
4.
Does the difference in the predicted truncation of lymph node metastasis between the right and
left colon in the article agree with known biological differences in colorectal cancer? Did the
study explore the underlying biological mechanisms for these differences?
5.
Is D3 lymph node dissection mentioned in the article appropriate for all patients? Does the extent
of lymph node dissection influence the detection rate and prognosis of lymph node metastasis?
Title: Preoperative CT Lymph Node Size as a Predictor of Nodal Metastasis in Resectable Colon
Cancer: A Retrospective Study of 694 Patients
Version: 2 Date: 10 Dec 2024
Reviewer's report:
1.
The measurements of lymph node size mentioned in the article were performed by an
experienced surgical oncologist, but were measures taken to evaluate and ensure consistency
and repeatability of the measurements? Was a blind test conducted by a second independent
evaluator to verify these measurements?
2.
How can I ensure that the lymph nodes measured on CT images are consistent with the lymph
nodes in the pathology report? Is it possible that some lymph nodes were missed on CT, or that
all metastatic lymph nodes were not identified in the pathology report?
3.
Did the paper consider building a predictive model that included other clinical and pathological
parameters besides lymph node size? For example, were tumor T-stage, patient BMI, tumor
location, etc. included in the model, and how did they affect model performance?
4.
Does the difference in the predicted truncation of lymph node metastasis between the right and
left colon in the article agree with known biological differences in colorectal cancer? Did the
study explore the underlying biological mechanisms for these differences?
5.
Is D3 lymph node dissection mentioned in the article appropriate for all patients? Does the extent
of lymph node dissection influence the detection rate and prognosis of lymph node metastasis?
Please review this paper.
user
Title: Preoperative CT Lymph Node Size as a Predictor of Nodal Metastasis in Resectable Colon
Cancer: A Retrospective Study of 694 Patients
Version: 2 Date: 10 Dec 2024
Reviewer's report:
1.
The measurements of lymph node size mentioned in the article were performed by an
experienced surgical oncologist, but were measures taken to evaluate and ensure consistency
and repeatability of the measurements? Was a blind test conducted by a second independent
evaluator to verify these measurements?
2.
How can I ensure that the lymph nodes measured on CT images are consistent with the lymph
nodes in the pathology report? Is it possible that some lymph nodes were missed on CT, or that
all metastatic lymph nodes were not identified in the pathology report?
3.
Did the paper consider building a predictive model that included other clinical and pathological
parameters besides lymph node size? For example, were tumor T-stage, patient BMI, tumor
location, etc. included in the model, and how did they affect model performance?
4.
Does the difference in the predicted truncation of lymph node metastasis between the right and
left colon in the article agree with known biological differences in colorectal cancer? Did the
study explore the underlying biological mechanisms for these differences?
5.
Is D3 lymph node dissection mentioned in the article appropriate for all patients? Does the extent
of lymph node dissection influence the detection rate and prognosis of lymph node metastasis?
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