Title: Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic
fatty liver disease: insights from the general population
Version: 0 Date: 18 Apr 2022
Reviewer's report:
The study demonstrated that people with the MHAO phenotype and MUAO phenotype have a
higher risk of NAFLD than those with the MNHAO phenotype, especially in females, which
emphasizes the importance of abdominal obesity as a risk factor for NAFLD and the importance
of strengthening the screening of NAFLD and related metabolic diseases in abdominal obese
people.
1. Among the included subjects, the total number of females is 6840, of which MHNAO is 4567,
so the proportion should be 66.77%, not 43.20%, the author should carefully check and correct it.
2. Among the male subjects included, the authors only listed the proportions of the three types of
MHAO, MUNAO and MUAO, it is recommended to add the proportion of MHNAO, which will
be more clear. In addition, the NAFLD prevalence rates of the four phenotypes in male subjects
are written in the paper, but this does not allow readers to clearly understand which phenotype
these numbers refer to specifically, and the authors are advised to express more clearly.
3. According to the result of this paper, “compared with the MHNAO phenotype, the association
of abdominal obesity phenotypes with NAFLD risk was relatively attenuated in male subjects”, it
is suggested that the author explain the causes of this phenomenon more deeply in the discussion
section, although the author has explained it slightly.
Title: Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic
fatty liver disease: insights from the general population
Version: 0 Date: 18 Apr 2022
Reviewer's report:
The study demonstrated that people with the MHAO phenotype and MUAO phenotype have a
higher risk of NAFLD than those with the MNHAO phenotype, especially in females, which
emphasizes the importance of abdominal obesity as a risk factor for NAFLD and the importance
of strengthening the screening of NAFLD and related metabolic diseases in abdominal obese
people.
1. Among the included subjects, the total number of females is 6840, of which MHNAO is 4567,
so the proportion should be 66.77%, not 43.20%, the author should carefully check and correct it.
2. Among the male subjects included, the authors only listed the proportions of the three types of
MHAO, MUNAO and MUAO, it is recommended to add the proportion of MHNAO, which will
be more clear. In addition, the NAFLD prevalence rates of the four phenotypes in male subjects
are written in the paper, but this does not allow readers to clearly understand which phenotype
these numbers refer to specifically, and the authors are advised to express more clearly.
3. According to the result of this paper, “compared with the MHNAO phenotype, the association
of abdominal obesity phenotypes with NAFLD risk was relatively attenuated in male subjects”, it
is suggested that the author explain the causes of this phenomenon more deeply in the discussion
section, although the author has explained it slightly.
Please review this paper.
user
Title: Abdominal obesity phenotypes are associated with the risk of developing non-alcoholic
fatty liver disease: insights from the general population
Version: 0 Date: 18 Apr 2022
Reviewer's report:
The study demonstrated that people with the MHAO phenotype and MUAO phenotype have a
higher risk of NAFLD than those with the MNHAO phenotype, especially in females, which
emphasizes the importance of abdominal obesity as a risk factor for NAFLD and the importance
of strengthening the screening of NAFLD and related metabolic diseases in abdominal obese
people.
1. Among the included subjects, the total number of females is 6840, of which MHNAO is 4567,
so the proportion should be 66.77%, not 43.20%, the author should carefully check and correct it.
2. Among the male subjects included, the authors only listed the proportions of the three types of
MHAO, MUNAO and MUAO, it is recommended to add the proportion of MHNAO, which will
be more clear. In addition, the NAFLD prevalence rates of the four phenotypes in male subjects
are written in the paper, but this does not allow readers to clearly understand which phenotype
these numbers refer to specifically, and the authors are advised to express more clearly.
3. According to the result of this paper, “compared with the MHNAO phenotype, the association
of abdominal obesity phenotypes with NAFLD risk was relatively attenuated in male subjects”, it
is suggested that the author explain the causes of this phenomenon more deeply in the discussion
section, although the author has explained it slightly.
assistant