Title: No significant relationship exists between tumor size and prognosis in distant metastatic
hepatocellular carcinoma#a propensity score matching analysis based on SEER database.
Version: 4 Date: 26 Nov 2021
Reviewer's report:
Thank you for the opportunity to review this manuscript by Xie et al regarding the impact of
tumor size on the prognosis of distant metastatic HCC
1.As authors concludes, the tumor size is not an independent prognostic factor for distant
metastatic HCC. why is it so important to this study? It may be good to add a few more details
to explain it in order to support the research question.
2.As authors mentioned, the study is based on SEER database, and the results should be limited
to American patients, instead of Asia or Europe, which should be commented.
3.How were the variables included in the propensity score chosen? caliper width#
4.The authors conduct a multivariate Cox regression in the matched cohort (Table 3). This MVA
includes variables that are also included in the PSM. This should not be done.
5.Data error in abstract (P=0.06). Title Error in Figure 3.
Title: No significant relationship exists between tumor size and prognosis in distant metastatic
hepatocellular carcinoma#a propensity score matching analysis based on SEER database.
Version: 4 Date: 26 Nov 2021
Reviewer's report:
Thank you for the opportunity to review this manuscript by Xie et al regarding the impact of
tumor size on the prognosis of distant metastatic HCC
1.As authors concludes, the tumor size is not an independent prognostic factor for distant
metastatic HCC. why is it so important to this study? It may be good to add a few more details
to explain it in order to support the research question.
2.As authors mentioned, the study is based on SEER database, and the results should be limited
to American patients, instead of Asia or Europe, which should be commented.
3.How were the variables included in the propensity score chosen? caliper width#
4.The authors conduct a multivariate Cox regression in the matched cohort (Table 3). This MVA
includes variables that are also included in the PSM. This should not be done.
5.Data error in abstract (P=0.06). Title Error in Figure 3.
Please review this paper.
user
Title: No significant relationship exists between tumor size and prognosis in distant metastatic
hepatocellular carcinoma#a propensity score matching analysis based on SEER database.
Version: 4 Date: 26 Nov 2021
Reviewer's report:
Thank you for the opportunity to review this manuscript by Xie et al regarding the impact of
tumor size on the prognosis of distant metastatic HCC
1.As authors concludes, the tumor size is not an independent prognostic factor for distant
metastatic HCC. why is it so important to this study? It may be good to add a few more details
to explain it in order to support the research question.
2.As authors mentioned, the study is based on SEER database, and the results should be limited
to American patients, instead of Asia or Europe, which should be commented.
3.How were the variables included in the propensity score chosen? caliper width#
4.The authors conduct a multivariate Cox regression in the matched cohort (Table 3). This MVA
includes variables that are also included in the PSM. This should not be done.
5.Data error in abstract (P=0.06). Title Error in Figure 3.
assistant