Reviewer's report
Title:High Prevalence of Celiac Disease among Saudi Children with Type 1
Diabetes
Version: 1Date:26 August 2012
Reviewer: Kamran Rostami
Reviewer's report:
I have read with interest the paper entitle “High Prevalence of Celiac Disease
among Saudi Children with Type 1 Diabetes” by Al-Hussaini et al. they evaluated
the prevalence rate and clinical characteristics of CD among Saudi children with
T1D suggesting the lower cut-off value of anti- tissue transglutaminase
antibodies IgA (anti-TTG) that best predicts CD in children with T1D.
There are already some studies on this topic in Saudi Arabia. A recent study with
even a bigger number >400 showed a similar prevalence of CD between T1D
(see below). The authors need to explain the differences and what this study add
to the current literature that is missing in the paper by Saadah et al?
Saadah OI et al Prevalence of celiac disease in children with type 1 diabetes
mellitus screened by anti-tissue transglutaminase antibody from Western Saudi
Arabia. Saudi Med J. 2012 May;33(5):541-6.
Some other comments
Method section:
The authors need to describe how the biopsies have been taken; like the number
of biopsies and the site of biopsies
Any biopsy taken from D1? Please adjust according to this reference
Kurien M, Evans KE, Hopper AD, Hale MF, Cross SS, Sanders DS. Duodenal
bulb biopsies for diagnosing adult celiac disease: is there an optimal biopsy site?
Gastrointest Endosc. 2012 Jun;75(6):1190-6.
Histology has not been discussed in this section either. Please describe your
finding according to the modified Marsh classification
- Ref 16 is the original Marsh Classification.
Rostami K, Kerckhaert J, Tiemessen R, von Blomberg BM, Meijer JW, et al.
Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac
disease: disappointing in clinical practice. Am J Gastroenterol 1999;94:888-94.
Level of interest: An article of importance in its field
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
Reviewer's report
Title:High Prevalence of Celiac Disease among Saudi Children with Type 1
Diabetes
Version: 1Date:26 August 2012
Reviewer: Kamran Rostami
Reviewer's report:
I have read with interest the paper entitle “High Prevalence of Celiac Disease
among Saudi Children with Type 1 Diabetes” by Al-Hussaini et al. they evaluated
the prevalence rate and clinical characteristics of CD among Saudi children with
T1D suggesting the lower cut-off value of anti- tissue transglutaminase
antibodies IgA (anti-TTG) that best predicts CD in children with T1D.
There are already some studies on this topic in Saudi Arabia. A recent study with
even a bigger number >400 showed a similar prevalence of CD between T1D
(see below). The authors need to explain the differences and what this study add
to the current literature that is missing in the paper by Saadah et al?
Saadah OI et al Prevalence of celiac disease in children with type 1 diabetes
mellitus screened by anti-tissue transglutaminase antibody from Western Saudi
Arabia. Saudi Med J. 2012 May;33(5):541-6.
Some other comments
Method section:
The authors need to describe how the biopsies have been taken; like the number
of biopsies and the site of biopsies
Any biopsy taken from D1? Please adjust according to this reference
Kurien M, Evans KE, Hopper AD, Hale MF, Cross SS, Sanders DS. Duodenal
bulb biopsies for diagnosing adult celiac disease: is there an optimal biopsy site?
Gastrointest Endosc. 2012 Jun;75(6):1190-6.
Histology has not been discussed in this section either. Please describe your
finding according to the modified Marsh classification
- Ref 16 is the original Marsh Classification.
Rostami K, Kerckhaert J, Tiemessen R, von Blomberg BM, Meijer JW, et al.
Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac
disease: disappointing in clinical practice. Am J Gastroenterol 1999;94:888-94.
Level of interest: An article of importance in its field
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:High Prevalence of Celiac Disease among Saudi Children with Type 1
Diabetes
Version: 1Date:26 August 2012
Reviewer: Kamran Rostami
Reviewer's report:
I have read with interest the paper entitle “High Prevalence of Celiac Disease
among Saudi Children with Type 1 Diabetes” by Al-Hussaini et al. they evaluated
the prevalence rate and clinical characteristics of CD among Saudi children with
T1D suggesting the lower cut-off value of anti- tissue transglutaminase
antibodies IgA (anti-TTG) that best predicts CD in children with T1D.
There are already some studies on this topic in Saudi Arabia. A recent study with
even a bigger number >400 showed a similar prevalence of CD between T1D
(see below). The authors need to explain the differences and what this study add
to the current literature that is missing in the paper by Saadah et al?
Saadah OI et al Prevalence of celiac disease in children with type 1 diabetes
mellitus screened by anti-tissue transglutaminase antibody from Western Saudi
Arabia. Saudi Med J. 2012 May;33(5):541-6.
Some other comments
Method section:
The authors need to describe how the biopsies have been taken; like the number
of biopsies and the site of biopsies
Any biopsy taken from D1? Please adjust according to this reference
Kurien M, Evans KE, Hopper AD, Hale MF, Cross SS, Sanders DS. Duodenal
bulb biopsies for diagnosing adult celiac disease: is there an optimal biopsy site?
Gastrointest Endosc. 2012 Jun;75(6):1190-6.
Histology has not been discussed in this section either. Please describe your
finding according to the modified Marsh classification
- Ref 16 is the original Marsh Classification.
Rostami K, Kerckhaert J, Tiemessen R, von Blomberg BM, Meijer JW, et al.
Sensitivity of antiendomysium and antigliadin antibodies in untreated celiac
disease: disappointing in clinical practice. Am J Gastroenterol 1999;94:888-94.
Level of interest: An article of importance in its field
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests
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