Title: Clinical characteristics and longitudinal changes of patients with non-alcoholic fatty liver
disease in two decades: the NAGALA study
Version: 2 Date: 01 Jan 2021
Reviewer's report:
Takuro Okamura et al. investigated the clinical characteristics and longitudinal changes of
NAFLD patients in two decades. This manuscript has a lot of data and is very interesting.
However, there are some problems described below.
1. The authors should list the clinical characteristics of study participants excluding intermediate
alcohol consumption group and alcoholic group at baseline examination.
2. Same as above, the authors should list the clinical characteristics of study participants without
obesity at baseline examination if they mention about non-obese NAFLD.
3. In discussion session, the manuscript states the following “The prevalence of metabolic
abnormalities, such as obesity and hyperglycemia in NAFLD patients significantly increased
through these two decades in men.” and “The prevalence of obesity in the current cohort
significantly increased for both genders, which might induce an increased prevalence of
NAFLD.”. However, in table 3, the prevalence of obesity in NAFLD patients did not increase
through two decades in men. In addition, in table 1, the prevalence of obesity in the current
cohort did not increased in women.
Title: Clinical characteristics and longitudinal changes of patients with non-alcoholic fatty liver
disease in two decades: the NAGALA study
Version: 2 Date: 01 Jan 2021
Reviewer's report:
Takuro Okamura et al. investigated the clinical characteristics and longitudinal changes of
NAFLD patients in two decades. This manuscript has a lot of data and is very interesting.
However, there are some problems described below.
1. The authors should list the clinical characteristics of study participants excluding intermediate
alcohol consumption group and alcoholic group at baseline examination.
2. Same as above, the authors should list the clinical characteristics of study participants without
obesity at baseline examination if they mention about non-obese NAFLD.
3. In discussion session, the manuscript states the following “The prevalence of metabolic
abnormalities, such as obesity and hyperglycemia in NAFLD patients significantly increased
through these two decades in men.” and “The prevalence of obesity in the current cohort
significantly increased for both genders, which might induce an increased prevalence of
NAFLD.”. However, in table 3, the prevalence of obesity in NAFLD patients did not increase
through two decades in men. In addition, in table 1, the prevalence of obesity in the current
cohort did not increased in women.
Please review this paper.
user
Title: Clinical characteristics and longitudinal changes of patients with non-alcoholic fatty liver
disease in two decades: the NAGALA study
Version: 2 Date: 01 Jan 2021
Reviewer's report:
Takuro Okamura et al. investigated the clinical characteristics and longitudinal changes of
NAFLD patients in two decades. This manuscript has a lot of data and is very interesting.
However, there are some problems described below.
1. The authors should list the clinical characteristics of study participants excluding intermediate
alcohol consumption group and alcoholic group at baseline examination.
2. Same as above, the authors should list the clinical characteristics of study participants without
obesity at baseline examination if they mention about non-obese NAFLD.
3. In discussion session, the manuscript states the following “The prevalence of metabolic
abnormalities, such as obesity and hyperglycemia in NAFLD patients significantly increased
through these two decades in men.” and “The prevalence of obesity in the current cohort
significantly increased for both genders, which might induce an increased prevalence of
NAFLD.”. However, in table 3, the prevalence of obesity in NAFLD patients did not increase
through two decades in men. In addition, in table 1, the prevalence of obesity in the current
cohort did not increased in women.
assistant