Reviewer ’s report  
 
Title: Multivisceral IgG4 -related disease presenting as recurrent massive gastrointestinal 
bleeding: a case report and literature review  
 
Version: 2 Date: 19 Jun 2018  
 
Reviewer: Chen Shuan Chung  
 
Reviewer's report:  
 
Some revisions should be made before consideration for publication.  
1. "Three cavity two capsules" were placed to hemostasis by compression and tube feeding 
hemostatic medicine. => Please explain what is "three cavity two capsules" more clearly.  
 
2. Page 4, line 58: Please provide normal range of IgG and IgG4.  
 
3. In figure 1, the CT images could not well delineate the lesion mentioned in the figure legend. 
I could not see LAPs in figure 1B, and the lesion indicated by the arrow in figure 1C should 
be the artery rather than a hypervascular lesion. Please provide CT images with better 
quality.  
 
4. In figure 2, the endoscopic picture of duodenal ulcer seemed to be not interesting. Do you 
have image enhanced endoscopic picture, such as NBI with magnifica tion, for the 
interpretation of duodenal ulcer with unusual etiology ? Is there any endoscopic hint 
indicating IgG4 related disease?  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the wor k include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
  
Are you a ble to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions : 
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shar es in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you rec eived reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interest s in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open pee r review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the autho rs' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be include d as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Multivisceral IgG4 -related disease presenting as recurrent massive gastrointestinal 
bleeding: a case report and literature review  
 
Version: 2 Date: 19 Jun 2018  
 
Reviewer: Chen Shuan Chung  
 
Reviewer's report:  
 
Some revisions should be made before consideration for publication.  
1. "Three cavity two capsules" were placed to hemostasis by compression and tube feeding 
hemostatic medicine. => Please explain what is "three cavity two capsules" more clearly.  
 
2. Page 4, line 58: Please provide normal range of IgG and IgG4.  
 
3. In figure 1, the CT images could not well delineate the lesion mentioned in the figure legend. 
I could not see LAPs in figure 1B, and the lesion indicated by the arrow in figure 1C should 
be the artery rather than a hypervascular lesion. Please provide CT images with better 
quality.  
 
4. In figure 2, the endoscopic picture of duodenal ulcer seemed to be not interesting. Do you 
have image enhanced endoscopic picture, such as NBI with magnifica tion, for the 
interpretation of duodenal ulcer with unusual etiology ? Is there any endoscopic hint 
indicating IgG4 related disease?  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the wor k include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
  
Are you a ble to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions : 
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shar es in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you rec eived reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interest s in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open pee r review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the autho rs' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be include d as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Multivisceral IgG4 -related disease presenting as recurrent massive gastrointestinal 
bleeding: a case report and literature review  
 
Version: 2 Date: 19 Jun 2018  
 
Reviewer: Chen Shuan Chung  
 
Reviewer's report:  
 
Some revisions should be made before consideration for publication.  
1. "Three cavity two capsules" were placed to hemostasis by compression and tube feeding 
hemostatic medicine. => Please explain what is "three cavity two capsules" more clearly.  
 
2. Page 4, line 58: Please provide normal range of IgG and IgG4.  
 
3. In figure 1, the CT images could not well delineate the lesion mentioned in the figure legend. 
I could not see LAPs in figure 1B, and the lesion indicated by the arrow in figure 1C should 
be the artery rather than a hypervascular lesion. Please provide CT images with better 
quality.  
 
4. In figure 2, the endoscopic picture of duodenal ulcer seemed to be not interesting. Do you 
have image enhanced endoscopic picture, such as NBI with magnifica tion, for the 
interpretation of duodenal ulcer with unusual etiology ? Is there any endoscopic hint 
indicating IgG4 related disease?  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the wor k include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
  
Are you a ble to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions : 
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shar es in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you rec eived reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interest s in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open pee r review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the autho rs' 
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be include d as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant