Reviewer's report
Title:Activation of transcription factor AP-1 in response to thermal injury in rat
small intestine and IEC-6 cells
Version:2Date:25 April 2015
Reviewer: Joerg Hoffmann
Reviewer's report:
If changes as followed are implemented:
Results: Heat stress resulted in severe damage to the epithelium of the small
intestine. The cell
morphology and viability were obviously altered when IEC-6 cells were exposed
to hyperthermia.
AP-1 was activated in the small intestine of heat-stressed rats, as was
phosphorylation of the JNK
signaling pathway. In the IEC-6 cell line, AP-1 activation was significantly
increased in groups exposed to 42°C for 1 h, 2 h and 4 h. In contrast, NF-#B was
not activated in both in vivo and in vitro
models.
Reviewer's report
Title:Activation of transcription factor AP-1 in response to thermal injury in rat
small intestine and IEC-6 cells
Version:2Date:25 April 2015
Reviewer: Joerg Hoffmann
Reviewer's report:
If changes as followed are implemented:
Results: Heat stress resulted in severe damage to the epithelium of the small
intestine. The cell
morphology and viability were obviously altered when IEC-6 cells were exposed
to hyperthermia.
AP-1 was activated in the small intestine of heat-stressed rats, as was
phosphorylation of the JNK
signaling pathway. In the IEC-6 cell line, AP-1 activation was significantly
increased in groups exposed to 42°C for 1 h, 2 h and 4 h. In contrast, NF-#B was
not activated in both in vivo and in vitro
models.
Please review this paper.
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Reviewer's report
Title:Activation of transcription factor AP-1 in response to thermal injury in rat
small intestine and IEC-6 cells
Version:2Date:25 April 2015
Reviewer: Joerg Hoffmann
Reviewer's report:
If changes as followed are implemented:
Results: Heat stress resulted in severe damage to the epithelium of the small
intestine. The cell
morphology and viability were obviously altered when IEC-6 cells were exposed
to hyperthermia.
AP-1 was activated in the small intestine of heat-stressed rats, as was
phosphorylation of the JNK
signaling pathway. In the IEC-6 cell line, AP-1 activation was significantly
increased in groups exposed to 42°C for 1 h, 2 h and 4 h. In contrast, NF-#B was
not activated in both in vivo and in vitro
models.
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