Title: Serum and Salivary Tissue Transglutaminase IGA (tTG-IGA) Level in Celiac Patients
Version: 1 Date: 16 Jun 2022
Reviewer's report:
- Once you have defined an abbreviation, use it in the whole text (see “celiac disease”)
- Try to explain why, in the Introduction, CD prevalence in Iran seems to be so high
- “The preferred test for detecting CD is IgA anti-tissue transglutaminase antibody (tTG IgA),
which delivers high sensitivity (93%) and specificity (95%).”
Add reference
- “biopsy of the small intestine”
duodenum
- Add in the Introduction the sensibility and specificity of salivary tests
- Why did you use diagnostic criteria of paediatric CD in an adult population?
- How is it possible that CD patients in GFD have positive antibodies anti-tTG?
- “CD manifests itself in a wide range of typical and atypical ways.”
Add a citation (for example: “Pediatric epilepsy and psychiatric comorbidity: could celiac
disease diagnosis improve the outcome? Minerva Pediatr. 2018 Dec;70(6):634-635. doi:
10.23736/S0026-4946.17.05122-2. Epub 2017 Nov 21. PMID: 29160641.”)
- Add the criticisms to your study
- “tTG levels in the blood and saliva of people with celiac disease are higher than those in healthy
individuals.”
CD in DGF ?!
- “Using diagnostic value tests, it was observed that salivary tTG levels can be used in screening
and even as an alternative in the diagnosis of celiac disease.”
You cannot say this because you had not compared with the gold standard of diagnosis, biopsy
- “Patients with celiac disease are also advised to take steps to prevent and treat dry mouth.”
How would they prevent dry mouth?
Title: Serum and Salivary Tissue Transglutaminase IGA (tTG-IGA) Level in Celiac Patients
Version: 1 Date: 16 Jun 2022
Reviewer's report:
- Once you have defined an abbreviation, use it in the whole text (see “celiac disease”)
- Try to explain why, in the Introduction, CD prevalence in Iran seems to be so high
- “The preferred test for detecting CD is IgA anti-tissue transglutaminase antibody (tTG IgA),
which delivers high sensitivity (93%) and specificity (95%).”
Add reference
- “biopsy of the small intestine”
duodenum
- Add in the Introduction the sensibility and specificity of salivary tests
- Why did you use diagnostic criteria of paediatric CD in an adult population?
- How is it possible that CD patients in GFD have positive antibodies anti-tTG?
- “CD manifests itself in a wide range of typical and atypical ways.”
Add a citation (for example: “Pediatric epilepsy and psychiatric comorbidity: could celiac
disease diagnosis improve the outcome? Minerva Pediatr. 2018 Dec;70(6):634-635. doi:
10.23736/S0026-4946.17.05122-2. Epub 2017 Nov 21. PMID: 29160641.”)
- Add the criticisms to your study
- “tTG levels in the blood and saliva of people with celiac disease are higher than those in healthy
individuals.”
CD in DGF ?!
- “Using diagnostic value tests, it was observed that salivary tTG levels can be used in screening
and even as an alternative in the diagnosis of celiac disease.”
You cannot say this because you had not compared with the gold standard of diagnosis, biopsy
- “Patients with celiac disease are also advised to take steps to prevent and treat dry mouth.”
How would they prevent dry mouth?
Please review this paper.
user
Title: Serum and Salivary Tissue Transglutaminase IGA (tTG-IGA) Level in Celiac Patients
Version: 1 Date: 16 Jun 2022
Reviewer's report:
- Once you have defined an abbreviation, use it in the whole text (see “celiac disease”)
- Try to explain why, in the Introduction, CD prevalence in Iran seems to be so high
- “The preferred test for detecting CD is IgA anti-tissue transglutaminase antibody (tTG IgA),
which delivers high sensitivity (93%) and specificity (95%).”
Add reference
- “biopsy of the small intestine”
duodenum
- Add in the Introduction the sensibility and specificity of salivary tests
- Why did you use diagnostic criteria of paediatric CD in an adult population?
- How is it possible that CD patients in GFD have positive antibodies anti-tTG?
- “CD manifests itself in a wide range of typical and atypical ways.”
Add a citation (for example: “Pediatric epilepsy and psychiatric comorbidity: could celiac
disease diagnosis improve the outcome? Minerva Pediatr. 2018 Dec;70(6):634-635. doi:
10.23736/S0026-4946.17.05122-2. Epub 2017 Nov 21. PMID: 29160641.”)
- Add the criticisms to your study
- “tTG levels in the blood and saliva of people with celiac disease are higher than those in healthy
individuals.”
CD in DGF ?!
- “Using diagnostic value tests, it was observed that salivary tTG levels can be used in screening
and even as an alternative in the diagnosis of celiac disease.”
You cannot say this because you had not compared with the gold standard of diagnosis, biopsy
- “Patients with celiac disease are also advised to take steps to prevent and treat dry mouth.”
How would they prevent dry mouth?
assistant