Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 2Date:28 January 2008
Reviewer: Hiroyuki Kuwano
Reviewer's report:
This original manuscript demonstrated the study showing the effect of
erythromycin on the colon motility of children with chronic constipation evaluated
by colon and antroduodenal manometries. This study is interesting, because
there are only a few reports for the effect of erythromycin on the colon motility of
children with chronic constitution. However, there are some points to be clarified
in this study to publish the journal.
Major comments
1. There was no Figure in this manuscript. Typical results of manotetric recording
for colonic examinations, including the effects of erythromycin, bisacodyl, and
meal (gastrocolic response) on the recording, should be demonstrated.
2. The results, including the effect of erythromycin on AUC, the patterns of
gastrocolic response, and an incidence of HAPC before and after the bisacodyl
administration, should be summarized in Tables.
3. The authors showed that there was no HAPC at the time following the meal. Is
this finding to be an abnormal? Is this finding a feature of patients with functional
constipation and/or fecal incontinence? There have been some reports that study
the colon manometry of pediatric patients with chronic constipation. The author
could refer the manometric results of these reports, and discuss or suggest the
feature of colonic motility in the patients with chronic constipation.
4. The authors should discuss the mechanism of down regulation of erythromycin
on the colonic motility. It would be thought that erythromycin should affect the
colonic motility because of significant down regulation after the administration of
erythromycin. Please discuss the mechanism of this phenomenon.
Minor comments
1. The patientsâ## profile was included in Results. This information would be
suitable to be described in Materials and Methods.
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 2Date:28 January 2008
Reviewer: Hiroyuki Kuwano
Reviewer's report:
This original manuscript demonstrated the study showing the effect of
erythromycin on the colon motility of children with chronic constipation evaluated
by colon and antroduodenal manometries. This study is interesting, because
there are only a few reports for the effect of erythromycin on the colon motility of
children with chronic constitution. However, there are some points to be clarified
in this study to publish the journal.
Major comments
1. There was no Figure in this manuscript. Typical results of manotetric recording
for colonic examinations, including the effects of erythromycin, bisacodyl, and
meal (gastrocolic response) on the recording, should be demonstrated.
2. The results, including the effect of erythromycin on AUC, the patterns of
gastrocolic response, and an incidence of HAPC before and after the bisacodyl
administration, should be summarized in Tables.
3. The authors showed that there was no HAPC at the time following the meal. Is
this finding to be an abnormal? Is this finding a feature of patients with functional
constipation and/or fecal incontinence? There have been some reports that study
the colon manometry of pediatric patients with chronic constipation. The author
could refer the manometric results of these reports, and discuss or suggest the
feature of colonic motility in the patients with chronic constipation.
4. The authors should discuss the mechanism of down regulation of erythromycin
on the colonic motility. It would be thought that erythromycin should affect the
colonic motility because of significant down regulation after the administration of
erythromycin. Please discuss the mechanism of this phenomenon.
Minor comments
1. The patientsâ## profile was included in Results. This information would be
suitable to be described in Materials and Methods.
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 2Date:28 January 2008
Reviewer: Hiroyuki Kuwano
Reviewer's report:
This original manuscript demonstrated the study showing the effect of
erythromycin on the colon motility of children with chronic constipation evaluated
by colon and antroduodenal manometries. This study is interesting, because
there are only a few reports for the effect of erythromycin on the colon motility of
children with chronic constitution. However, there are some points to be clarified
in this study to publish the journal.
Major comments
1. There was no Figure in this manuscript. Typical results of manotetric recording
for colonic examinations, including the effects of erythromycin, bisacodyl, and
meal (gastrocolic response) on the recording, should be demonstrated.
2. The results, including the effect of erythromycin on AUC, the patterns of
gastrocolic response, and an incidence of HAPC before and after the bisacodyl
administration, should be summarized in Tables.
3. The authors showed that there was no HAPC at the time following the meal. Is
this finding to be an abnormal? Is this finding a feature of patients with functional
constipation and/or fecal incontinence? There have been some reports that study
the colon manometry of pediatric patients with chronic constipation. The author
could refer the manometric results of these reports, and discuss or suggest the
feature of colonic motility in the patients with chronic constipation.
4. The authors should discuss the mechanism of down regulation of erythromycin
on the colonic motility. It would be thought that erythromycin should affect the
colonic motility because of significant down regulation after the administration of
erythromycin. Please discuss the mechanism of this phenomenon.
Minor comments
1. The patientsâ## profile was included in Results. This information would be
suitable to be described in Materials and Methods.
What next?: Unable to decide on acceptance or rejection until the authors have
responded to the major compulsory revisions
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant