Reviewer's report
Title:Meta-analysis of radiofrequency ablation versus hepatic resection for
hepatocellular carcinoma
Version: 1Date:28 January 2010
Reviewer: Kazutaka Kurokohchi
Reviewer's report:
Review for Meta-analysis of radiofrequency ablation versus hepatic resection for
hepatocellular carcinoma by Zhou et. al.
The present study represents the results of systemic review and meta-analysis
of studies comparing the therapeutic effects against hepatocellular carcinoma
(HCC) between hepatic resection (HR) and radiofrequency ablation (RFA).
Authors analyzed overall survival, local intrahepatic recurrence, disease-free
survival rates etc., and concluded that HR was superior to RFA in the treatment
of patients with HCC eligible for surgical treatments.
Major concern: As everyone knows at present, adaptation of RFA is considered
to be suitable for HCC within 3 nodules and 3 cm in diameter in the liver. It is
important to treat HCCs within 3 nodules, 3cm in diameter in the liver and those
over 3 nodules, 3 cm separately. Thus, in case comparing the therapeutic effects
of HR and RFA for HCC, the number and size of HCCs should be adjusted
between HR and RFA. In this manuscript, authors show there was no significant
difference in overall and disease-free survival between HR and RFA groups for
patients with tumors < 3cm. Therefore, content of conclusions can not be
accepted as it is in this manuscript. Analysis and conclusions should be changed
according to the tumor number and size in the liver.
The manuscript should be reconsidered for publication after major revision.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Meta-analysis of radiofrequency ablation versus hepatic resection for
hepatocellular carcinoma
Version: 1Date:28 January 2010
Reviewer: Kazutaka Kurokohchi
Reviewer's report:
Review for Meta-analysis of radiofrequency ablation versus hepatic resection for
hepatocellular carcinoma by Zhou et. al.
The present study represents the results of systemic review and meta-analysis
of studies comparing the therapeutic effects against hepatocellular carcinoma
(HCC) between hepatic resection (HR) and radiofrequency ablation (RFA).
Authors analyzed overall survival, local intrahepatic recurrence, disease-free
survival rates etc., and concluded that HR was superior to RFA in the treatment
of patients with HCC eligible for surgical treatments.
Major concern: As everyone knows at present, adaptation of RFA is considered
to be suitable for HCC within 3 nodules and 3 cm in diameter in the liver. It is
important to treat HCCs within 3 nodules, 3cm in diameter in the liver and those
over 3 nodules, 3 cm separately. Thus, in case comparing the therapeutic effects
of HR and RFA for HCC, the number and size of HCCs should be adjusted
between HR and RFA. In this manuscript, authors show there was no significant
difference in overall and disease-free survival between HR and RFA groups for
patients with tumors < 3cm. Therefore, content of conclusions can not be
accepted as it is in this manuscript. Analysis and conclusions should be changed
according to the tumor number and size in the liver.
The manuscript should be reconsidered for publication after major revision.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Meta-analysis of radiofrequency ablation versus hepatic resection for
hepatocellular carcinoma
Version: 1Date:28 January 2010
Reviewer: Kazutaka Kurokohchi
Reviewer's report:
Review for Meta-analysis of radiofrequency ablation versus hepatic resection for
hepatocellular carcinoma by Zhou et. al.
The present study represents the results of systemic review and meta-analysis
of studies comparing the therapeutic effects against hepatocellular carcinoma
(HCC) between hepatic resection (HR) and radiofrequency ablation (RFA).
Authors analyzed overall survival, local intrahepatic recurrence, disease-free
survival rates etc., and concluded that HR was superior to RFA in the treatment
of patients with HCC eligible for surgical treatments.
Major concern: As everyone knows at present, adaptation of RFA is considered
to be suitable for HCC within 3 nodules and 3 cm in diameter in the liver. It is
important to treat HCCs within 3 nodules, 3cm in diameter in the liver and those
over 3 nodules, 3 cm separately. Thus, in case comparing the therapeutic effects
of HR and RFA for HCC, the number and size of HCCs should be adjusted
between HR and RFA. In this manuscript, authors show there was no significant
difference in overall and disease-free survival between HR and RFA groups for
patients with tumors < 3cm. Therefore, content of conclusions can not be
accepted as it is in this manuscript. Analysis and conclusions should be changed
according to the tumor number and size in the liver.
The manuscript should be reconsidered for publication after major revision.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant