Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 2 Date: 22 Mar 2022
Reviewer's report:
The authors address a clinically important question of differentiating CD and ITB in the
developing regions which are endemic for intestinal TB, and where the prevalence of CD
is increasing. The study has been well performed, statistically sound and relevant. Some
suggestions
1. Can the authors describe the multivariate analysis in further detail, especially about the other
parameters which were significant in univariate analysis.
2. 60% patients with ITB had pulmonary involvement. How was it diagnosed, and were all these
patients having active TB ?
3. If no patient with CD had pulmonary TB (0 vs60%), then why was this feature not significant
in multivariate analysis ?
4. Similarly, there are some other features which are having a very high odds ratio in univariate
analysis but are not coming significant in univariate analysis.
5. The study will improve if the authors validate this model in a separate cohort of patients with
CD and ITB.
6. There are spelling errors at places.
Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 2 Date: 22 Mar 2022
Reviewer's report:
The authors address a clinically important question of differentiating CD and ITB in the
developing regions which are endemic for intestinal TB, and where the prevalence of CD
is increasing. The study has been well performed, statistically sound and relevant. Some
suggestions
1. Can the authors describe the multivariate analysis in further detail, especially about the other
parameters which were significant in univariate analysis.
2. 60% patients with ITB had pulmonary involvement. How was it diagnosed, and were all these
patients having active TB ?
3. If no patient with CD had pulmonary TB (0 vs60%), then why was this feature not significant
in multivariate analysis ?
4. Similarly, there are some other features which are having a very high odds ratio in univariate
analysis but are not coming significant in univariate analysis.
5. The study will improve if the authors validate this model in a separate cohort of patients with
CD and ITB.
6. There are spelling errors at places.
Please review this paper.
user
Title: Differential diagnosis of Crohn's disease and intestinal tuberculosis: development and
assessment of a nomogram prediction model
Version: 2 Date: 22 Mar 2022
Reviewer's report:
The authors address a clinically important question of differentiating CD and ITB in the
developing regions which are endemic for intestinal TB, and where the prevalence of CD
is increasing. The study has been well performed, statistically sound and relevant. Some
suggestions
1. Can the authors describe the multivariate analysis in further detail, especially about the other
parameters which were significant in univariate analysis.
2. 60% patients with ITB had pulmonary involvement. How was it diagnosed, and were all these
patients having active TB ?
3. If no patient with CD had pulmonary TB (0 vs60%), then why was this feature not significant
in multivariate analysis ?
4. Similarly, there are some other features which are having a very high odds ratio in univariate
analysis but are not coming significant in univariate analysis.
5. The study will improve if the authors validate this model in a separate cohort of patients with
CD and ITB.
6. There are spelling errors at places.
assistant