Reviewer's report
Title:Obesity and diabetes mellitus and/or hyperlipidaemia are independent risk
factors for pre-transplant portal venous thrombosis in liver recipients
Version: 3Date:29 April 2012
Reviewer: aurelie plessier
Reviewer's report:
The authors report the incidence and risk factors for portal vein thrombosis in
patients with cirrhosis prior to liver transplantation. Obesity and diabetes or
hyperlipidemia are significantly associated to PVT in multivariate analysis. This is
an interesting manuscript although minor essential revisions are needed.
1. Number of JAK 2 mutation screening is not clearly reported.
2. Thrombophilia screening seems to be missing (65 out of 89 in the thrombotic
group and 228 out of 376 in the non thrombotic group). Indeed study population
is said to be of 293 men and 144 women. But it seems that only 290 were
screened. This is not very clear and should be clarified in paragraph recipients p
4. Other form aspects should be corrected
3. What explanation can be given as to the "protective effect" of nephrotic
syndrome and smoking which are inversely associated to the absence of
thrombotic event
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests below
Reviewer's report
Title:Obesity and diabetes mellitus and/or hyperlipidaemia are independent risk
factors for pre-transplant portal venous thrombosis in liver recipients
Version: 3Date:29 April 2012
Reviewer: aurelie plessier
Reviewer's report:
The authors report the incidence and risk factors for portal vein thrombosis in
patients with cirrhosis prior to liver transplantation. Obesity and diabetes or
hyperlipidemia are significantly associated to PVT in multivariate analysis. This is
an interesting manuscript although minor essential revisions are needed.
1. Number of JAK 2 mutation screening is not clearly reported.
2. Thrombophilia screening seems to be missing (65 out of 89 in the thrombotic
group and 228 out of 376 in the non thrombotic group). Indeed study population
is said to be of 293 men and 144 women. But it seems that only 290 were
screened. This is not very clear and should be clarified in paragraph recipients p
4. Other form aspects should be corrected
3. What explanation can be given as to the "protective effect" of nephrotic
syndrome and smoking which are inversely associated to the absence of
thrombotic event
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests below
Please review this paper.
user
Reviewer's report
Title:Obesity and diabetes mellitus and/or hyperlipidaemia are independent risk
factors for pre-transplant portal venous thrombosis in liver recipients
Version: 3Date:29 April 2012
Reviewer: aurelie plessier
Reviewer's report:
The authors report the incidence and risk factors for portal vein thrombosis in
patients with cirrhosis prior to liver transplantation. Obesity and diabetes or
hyperlipidemia are significantly associated to PVT in multivariate analysis. This is
an interesting manuscript although minor essential revisions are needed.
1. Number of JAK 2 mutation screening is not clearly reported.
2. Thrombophilia screening seems to be missing (65 out of 89 in the thrombotic
group and 228 out of 376 in the non thrombotic group). Indeed study population
is said to be of 293 men and 144 women. But it seems that only 290 were
screened. This is not very clear and should be clarified in paragraph recipients p
4. Other form aspects should be corrected
3. What explanation can be given as to the "protective effect" of nephrotic
syndrome and smoking which are inversely associated to the absence of
thrombotic event
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests below
assistant