Title: Clinical characteristics and risk factors of organ failure and death in necrotizing
pancreatitis
Version: 1 Date: 08 Dec 2022
Reviewer:  Serena Stigliano
Reviewer's report:
In the present study the authors have focused their attention on an important aspect of a less
common group of acute pancreatitis, the necrotizing pancreatitis. Indeed, there a few studies
investigating which are the factors associated with the worsening of clinical course in necrotizing
pancreatitis.
Despite English language should be revised, the argument is interesting and should be taken in
consideration for publication.
However I have some comments:
- The study is a retrospective study  and thus it can only describe an association between specific
features and the OF and death in NP. Therefore is better to modify this part: Thus, in our research,
we would not only addressed the risk factors of OF and death in NP patients, but further identified
simple parameters that can discriminate high-risk patients.
- At page 8: Patterns of necrosis in NP may involve a combination of pancreatic and
peripancreatic parenchyma, isolated peripancreatic necrosis, or, less commonly, isolated
pancreatic necrosis is written twice. Please check.
- In the methods section the authors say: Fluid requirements should be reassessed at frequent
intervals within 6 h of admission and for the next 24 – 48 h. The goal of aggressive hydration
should be to decrease the blood urea nitrogen.
Is it done? It is a retrospective study so it had to be collected. I suggest to remove this part.
In the results part:
- The mean age of onset in the no OF group was lower than that in the OF group, and the
difference was significant (P < 0.05) is the same concept of “Compared to patients without OF,
the OF patients were older (49.3±14.4 vs 45.5±13.5, p < 0.05)”. Please choose one of the two
sentences.
-Is not clear what authors means with this sentence: The main local complications among the
NP patients was ANC (78.2%), a similar incidence of ANC in the OF group (72.2%), and the
ratio in no OF group was 92.3%. Please rephrase.
- Authors should better specify what they mean with the term “shock”.
Title: Clinical characteristics and risk factors of organ failure and death in necrotizing
pancreatitis
Version: 1 Date: 08 Dec 2022
Reviewer:  Serena Stigliano
Reviewer's report:
In the present study the authors have focused their attention on an important aspect of a less
common group of acute pancreatitis, the necrotizing pancreatitis. Indeed, there a few studies
investigating which are the factors associated with the worsening of clinical course in necrotizing
pancreatitis.
Despite English language should be revised, the argument is interesting and should be taken in
consideration for publication.
However I have some comments:
- The study is a retrospective study  and thus it can only describe an association between specific
features and the OF and death in NP. Therefore is better to modify this part: Thus, in our research,
we would not only addressed the risk factors of OF and death in NP patients, but further identified
simple parameters that can discriminate high-risk patients.
- At page 8: Patterns of necrosis in NP may involve a combination of pancreatic and
peripancreatic parenchyma, isolated peripancreatic necrosis, or, less commonly, isolated
pancreatic necrosis is written twice. Please check.
- In the methods section the authors say: Fluid requirements should be reassessed at frequent
intervals within 6 h of admission and for the next 24 – 48 h. The goal of aggressive hydration
should be to decrease the blood urea nitrogen.
Is it done? It is a retrospective study so it had to be collected. I suggest to remove this part.
In the results part:
- The mean age of onset in the no OF group was lower than that in the OF group, and the
difference was significant (P < 0.05) is the same concept of “Compared to patients without OF,
the OF patients were older (49.3±14.4 vs 45.5±13.5, p < 0.05)”. Please choose one of the two
sentences.
-Is not clear what authors means with this sentence: The main local complications among the
NP patients was ANC (78.2%), a similar incidence of ANC in the OF group (72.2%), and the
ratio in no OF group was 92.3%. Please rephrase.
- Authors should better specify what they mean with the term “shock”.
Please review this paper.
user
Title: Clinical characteristics and risk factors of organ failure and death in necrotizing
pancreatitis
Version: 1 Date: 08 Dec 2022
Reviewer:  Serena Stigliano
Reviewer's report:
In the present study the authors have focused their attention on an important aspect of a less
common group of acute pancreatitis, the necrotizing pancreatitis. Indeed, there a few studies
investigating which are the factors associated with the worsening of clinical course in necrotizing
pancreatitis.
Despite English language should be revised, the argument is interesting and should be taken in
consideration for publication.
However I have some comments:
- The study is a retrospective study  and thus it can only describe an association between specific
features and the OF and death in NP. Therefore is better to modify this part: Thus, in our research,
we would not only addressed the risk factors of OF and death in NP patients, but further identified
simple parameters that can discriminate high-risk patients.
- At page 8: Patterns of necrosis in NP may involve a combination of pancreatic and
peripancreatic parenchyma, isolated peripancreatic necrosis, or, less commonly, isolated
pancreatic necrosis is written twice. Please check.
- In the methods section the authors say: Fluid requirements should be reassessed at frequent
intervals within 6 h of admission and for the next 24 – 48 h. The goal of aggressive hydration
should be to decrease the blood urea nitrogen.
Is it done? It is a retrospective study so it had to be collected. I suggest to remove this part.
In the results part:
- The mean age of onset in the no OF group was lower than that in the OF group, and the
difference was significant (P < 0.05) is the same concept of “Compared to patients without OF,
the OF patients were older (49.3±14.4 vs 45.5±13.5, p < 0.05)”. Please choose one of the two
sentences.
-Is not clear what authors means with this sentence: The main local complications among the
NP patients was ANC (78.2%), a similar incidence of ANC in the OF group (72.2%), and the
ratio in no OF group was 92.3%. Please rephrase.
- Authors should better specify what they mean with the term “shock”.
assistant