Title: Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on
esophageal motility: a systematic review
Version: 5 Date: 27 Feb 2023
Reviewer's report:
The paper still lacks a structured format for easy readability. The results are confusing.
The outcome and results are confusing whether they are dealing with normal esophageal function
or motility disorder. The study by Kim HS et al also includes GERD. The results should be
shown separately for normal esophagus and for other diseases excluding GERD subset.
When you already are able to do meta-analysis of studies, case reports better be excluded. The
results of the qualitative section have to be organized and cut short in a better way.
And the other problem is a study of two case reports (Fox et al) was not included in either table
1 or 2.  To add to this confusion, the study by Fox et al has been cited twice in references (Ref
17 and Ref 29).
Please add the quality of studies as good or fair in assessment in the results section. JBI case
report appraisal suggests the use of include or exclude or seek further info as overall appraisal.
Title: Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on
esophageal motility: a systematic review
Version: 5 Date: 27 Feb 2023
Reviewer's report:
The paper still lacks a structured format for easy readability. The results are confusing.
The outcome and results are confusing whether they are dealing with normal esophageal function
or motility disorder. The study by Kim HS et al also includes GERD. The results should be
shown separately for normal esophagus and for other diseases excluding GERD subset.
When you already are able to do meta-analysis of studies, case reports better be excluded. The
results of the qualitative section have to be organized and cut short in a better way.
And the other problem is a study of two case reports (Fox et al) was not included in either table
1 or 2.  To add to this confusion, the study by Fox et al has been cited twice in references (Ref
17 and Ref 29).
Please add the quality of studies as good or fair in assessment in the results section. JBI case
report appraisal suggests the use of include or exclude or seek further info as overall appraisal.
Please review this paper.
user
Title: Phosphodiesterase 5 (PDE-5) inhibitors (sildenafil, tadalafil, and vardenafil) effects on
esophageal motility: a systematic review
Version: 5 Date: 27 Feb 2023
Reviewer's report:
The paper still lacks a structured format for easy readability. The results are confusing.
The outcome and results are confusing whether they are dealing with normal esophageal function
or motility disorder. The study by Kim HS et al also includes GERD. The results should be
shown separately for normal esophagus and for other diseases excluding GERD subset.
When you already are able to do meta-analysis of studies, case reports better be excluded. The
results of the qualitative section have to be organized and cut short in a better way.
And the other problem is a study of two case reports (Fox et al) was not included in either table
1 or 2.  To add to this confusion, the study by Fox et al has been cited twice in references (Ref
17 and Ref 29).
Please add the quality of studies as good or fair in assessment in the results section. JBI case
report appraisal suggests the use of include or exclude or seek further info as overall appraisal.
assistant