Title: The effects of chemotherapy, primary tumor location and histological subtype on the
survival of stage III colon cancer patients
Version: 0 Date: 24 Jan 2023
Reviewer's report:
a well written manuscript in which tumor location (RCC, LCC) chemo (Yes, NO) and histology
(AC, MAC) were evaluated in detail. I would recommand running a multivate Cox model with
only these 3 factors interacted with each other. The reference group will be LCC+AC+ No
chemo. The rest combinations will be comparison groups. Please show the result like your figure
7.
You can then add other patient, tumor or enviromental characterisics like your figure 7 to confirm
your result is similiar to the uncontrolled result as above.
lastly, cause of death is available in SEER . Please evaluate or comment on its potential impact
on your results and findings using overall survival. Patients who received chemo were more
likely to be healthier and influence the OS to some extent.
Title: The effects of chemotherapy, primary tumor location and histological subtype on the
survival of stage III colon cancer patients
Version: 0 Date: 24 Jan 2023
Reviewer's report:
a well written manuscript in which tumor location (RCC, LCC) chemo (Yes, NO) and histology
(AC, MAC) were evaluated in detail. I would recommand running a multivate Cox model with
only these 3 factors interacted with each other. The reference group will be LCC+AC+ No
chemo. The rest combinations will be comparison groups. Please show the result like your figure
7.
You can then add other patient, tumor or enviromental characterisics like your figure 7 to confirm
your result is similiar to the uncontrolled result as above.
lastly, cause of death is available in SEER . Please evaluate or comment on its potential impact
on your results and findings using overall survival. Patients who received chemo were more
likely to be healthier and influence the OS to some extent.
Please review this paper.
user
Title: The effects of chemotherapy, primary tumor location and histological subtype on the
survival of stage III colon cancer patients
Version: 0 Date: 24 Jan 2023
Reviewer's report:
a well written manuscript in which tumor location (RCC, LCC) chemo (Yes, NO) and histology
(AC, MAC) were evaluated in detail. I would recommand running a multivate Cox model with
only these 3 factors interacted with each other. The reference group will be LCC+AC+ No
chemo. The rest combinations will be comparison groups. Please show the result like your figure
7.
You can then add other patient, tumor or enviromental characterisics like your figure 7 to confirm
your result is similiar to the uncontrolled result as above.
lastly, cause of death is available in SEER . Please evaluate or comment on its potential impact
on your results and findings using overall survival. Patients who received chemo were more
likely to be healthier and influence the OS to some extent.
assistant