Title: Dynamic Changes in Liver Stiffness Measurement by 2D Shear-wave Elastography
Predict Hepatocellular Carcinoma in Patients with Chronic Hepatitis B and Well-controlled
Viremia: A Retrospective Study
Version: 2 Date: 12 Apr 2025
Reviewer's report:
Although the idea of this study is very challenging to accurately predict the risk of HCC
in patients with well controlled viremia trying to create a new model, I have some critical
comments:
-In the methodology; The study design isn’t clear, and it should be rephrased to be more
understandable.
-the authors mentioned that there are 45 cirrhotic cases out of 303 total cases and then in Figure
1, you subclassified the 303 patients into 276 without HCC and 27 with HCC without revealing
the liver status of each group? So between 27 patients how many was cirrhotic?
- the number of  patients whom developed HCC (27 patients) is too small to validate the
conclusion as well as the model.
-To evaluate the dynamic changes in the LSM for the patients; you need to set a criteria for
follow up and duration to validate your results , so what was the time line for the follow up and
how you select the cut off value (I mean the number of the visits and its timing and the overall
follow up period).
-In the conclusion; you highlighted that you set a novel model , this model should be well
demonstrated in the results section
-The article need English editing.
Title: Dynamic Changes in Liver Stiffness Measurement by 2D Shear-wave Elastography
Predict Hepatocellular Carcinoma in Patients with Chronic Hepatitis B and Well-controlled
Viremia: A Retrospective Study
Version: 2 Date: 12 Apr 2025
Reviewer's report:
Although the idea of this study is very challenging to accurately predict the risk of HCC
in patients with well controlled viremia trying to create a new model, I have some critical
comments:
-In the methodology; The study design isn’t clear, and it should be rephrased to be more
understandable.
-the authors mentioned that there are 45 cirrhotic cases out of 303 total cases and then in Figure
1, you subclassified the 303 patients into 276 without HCC and 27 with HCC without revealing
the liver status of each group? So between 27 patients how many was cirrhotic?
- the number of  patients whom developed HCC (27 patients) is too small to validate the
conclusion as well as the model.
-To evaluate the dynamic changes in the LSM for the patients; you need to set a criteria for
follow up and duration to validate your results , so what was the time line for the follow up and
how you select the cut off value (I mean the number of the visits and its timing and the overall
follow up period).
-In the conclusion; you highlighted that you set a novel model , this model should be well
demonstrated in the results section
-The article need English editing.
Please review this paper.
user
Title: Dynamic Changes in Liver Stiffness Measurement by 2D Shear-wave Elastography
Predict Hepatocellular Carcinoma in Patients with Chronic Hepatitis B and Well-controlled
Viremia: A Retrospective Study
Version: 2 Date: 12 Apr 2025
Reviewer's report:
Although the idea of this study is very challenging to accurately predict the risk of HCC
in patients with well controlled viremia trying to create a new model, I have some critical
comments:
-In the methodology; The study design isn’t clear, and it should be rephrased to be more
understandable.
-the authors mentioned that there are 45 cirrhotic cases out of 303 total cases and then in Figure
1, you subclassified the 303 patients into 276 without HCC and 27 with HCC without revealing
the liver status of each group? So between 27 patients how many was cirrhotic?
- the number of  patients whom developed HCC (27 patients) is too small to validate the
conclusion as well as the model.
-To evaluate the dynamic changes in the LSM for the patients; you need to set a criteria for
follow up and duration to validate your results , so what was the time line for the follow up and
how you select the cut off value (I mean the number of the visits and its timing and the overall
follow up period).
-In the conclusion; you highlighted that you set a novel model , this model should be well
demonstrated in the results section
-The article need English editing.
assistant