Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 2 Date: 28 Oct 2024
Reviewer's report:
The authors present a review of health-related quality of life of patients with intestinal failure
(excluding those with neurodevelopmental delay) and a healthy comparator. It was written well
and is easy to understand. Nonetheless, that are a few points that I think are important for the
authors to address in a revised version of their manuscript.
1. In the HRQOL Total Summary section you discuss the differences between self-report and
proxy-report, but there is no information in the main text or Table 1 as to the papers you are
referring to that fell within these two groups. I understand the supplementary data lists the papers
that represent these two groups. However, I believe it would be worth including this is the main
text or Table 1. Please include a column in Table 1 or include the citation of papers that fall
into these groups.
2. Table 1. Please be consistent with how you report the age range and clearly detail the type of
measure used for each study (eg. mean or median).
3. Methodological differences between the studies selected for review was mentioned in your
discussion. Can you please elaborate on these and whether they had an impact upon the findings
etc? For example, age of the child varied across studies reviewed - could this impact upon the
findings? Are older/younger children more likely to have higher/lower HRQoL?
4. In your findings you state agreement of self-report and proxy-report findings. Since a few of
the studies reviewed reported both self-report and proxy-report findings, did these studies report
agreement in their sample?  I think this is important to discuss.
4. The abbreviation list is missing a few terms that were used. Please include all of the
abbreviations used.
5. There were also a few minor typos.
Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 2 Date: 28 Oct 2024
Reviewer's report:
The authors present a review of health-related quality of life of patients with intestinal failure
(excluding those with neurodevelopmental delay) and a healthy comparator. It was written well
and is easy to understand. Nonetheless, that are a few points that I think are important for the
authors to address in a revised version of their manuscript.
1. In the HRQOL Total Summary section you discuss the differences between self-report and
proxy-report, but there is no information in the main text or Table 1 as to the papers you are
referring to that fell within these two groups. I understand the supplementary data lists the papers
that represent these two groups. However, I believe it would be worth including this is the main
text or Table 1. Please include a column in Table 1 or include the citation of papers that fall
into these groups.
2. Table 1. Please be consistent with how you report the age range and clearly detail the type of
measure used for each study (eg. mean or median).
3. Methodological differences between the studies selected for review was mentioned in your
discussion. Can you please elaborate on these and whether they had an impact upon the findings
etc? For example, age of the child varied across studies reviewed - could this impact upon the
findings? Are older/younger children more likely to have higher/lower HRQoL?
4. In your findings you state agreement of self-report and proxy-report findings. Since a few of
the studies reviewed reported both self-report and proxy-report findings, did these studies report
agreement in their sample?  I think this is important to discuss.
4. The abbreviation list is missing a few terms that were used. Please include all of the
abbreviations used.
5. There were also a few minor typos.
Please review this paper.
user
Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 2 Date: 28 Oct 2024
Reviewer's report:
The authors present a review of health-related quality of life of patients with intestinal failure
(excluding those with neurodevelopmental delay) and a healthy comparator. It was written well
and is easy to understand. Nonetheless, that are a few points that I think are important for the
authors to address in a revised version of their manuscript.
1. In the HRQOL Total Summary section you discuss the differences between self-report and
proxy-report, but there is no information in the main text or Table 1 as to the papers you are
referring to that fell within these two groups. I understand the supplementary data lists the papers
that represent these two groups. However, I believe it would be worth including this is the main
text or Table 1. Please include a column in Table 1 or include the citation of papers that fall
into these groups.
2. Table 1. Please be consistent with how you report the age range and clearly detail the type of
measure used for each study (eg. mean or median).
3. Methodological differences between the studies selected for review was mentioned in your
discussion. Can you please elaborate on these and whether they had an impact upon the findings
etc? For example, age of the child varied across studies reviewed - could this impact upon the
findings? Are older/younger children more likely to have higher/lower HRQoL?
4. In your findings you state agreement of self-report and proxy-report findings. Since a few of
the studies reviewed reported both self-report and proxy-report findings, did these studies report
agreement in their sample?  I think this is important to discuss.
4. The abbreviation list is missing a few terms that were used. Please include all of the
abbreviations used.
5. There were also a few minor typos.
assistant