Title: Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with
hepatocellular carcinoma subjected to hepatectomy
Version: 1 Date: 12 Apr 2022
Reviewer:  Taku Aoki
Reviewer's report:
In the present manuscript, Mai et al. examined the impact of fibrinogen-to-albumin (FAR) on
patient outcomes with hepatocellular carcinoma (HCC) undergoing surgery. They concluded
that this parameter was useful for predicting prognoses of patients with HCC, and its impact
was greater than that of alpha-fetoprotein.
1. What is the clinical relevance of this factor? If the value is high, do the authors abandon
the operation? Numerous papers have evaluated the significance of inflammation/nutrition-
associated parameters in patients with HCC, and this paper dealt with another novel index.
However, none of them has been introduced into the daily practice of HCC.
2. The authors estimated the value of FAR in the same cohort. The authors are requested to
validate the significance of FAR in another validation cohort.
Title: Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with
hepatocellular carcinoma subjected to hepatectomy
Version: 1 Date: 12 Apr 2022
Reviewer:  Taku Aoki
Reviewer's report:
In the present manuscript, Mai et al. examined the impact of fibrinogen-to-albumin (FAR) on
patient outcomes with hepatocellular carcinoma (HCC) undergoing surgery. They concluded
that this parameter was useful for predicting prognoses of patients with HCC, and its impact
was greater than that of alpha-fetoprotein.
1. What is the clinical relevance of this factor? If the value is high, do the authors abandon
the operation? Numerous papers have evaluated the significance of inflammation/nutrition-
associated parameters in patients with HCC, and this paper dealt with another novel index.
However, none of them has been introduced into the daily practice of HCC.
2. The authors estimated the value of FAR in the same cohort. The authors are requested to
validate the significance of FAR in another validation cohort.
Please review this paper.
user
Title: Preoperative fibrinogen-to-albumin ratio predicts the prognosis of patients with
hepatocellular carcinoma subjected to hepatectomy
Version: 1 Date: 12 Apr 2022
Reviewer:  Taku Aoki
Reviewer's report:
In the present manuscript, Mai et al. examined the impact of fibrinogen-to-albumin (FAR) on
patient outcomes with hepatocellular carcinoma (HCC) undergoing surgery. They concluded
that this parameter was useful for predicting prognoses of patients with HCC, and its impact
was greater than that of alpha-fetoprotein.
1. What is the clinical relevance of this factor? If the value is high, do the authors abandon
the operation? Numerous papers have evaluated the significance of inflammation/nutrition-
associated parameters in patients with HCC, and this paper dealt with another novel index.
However, none of them has been introduced into the daily practice of HCC.
2. The authors estimated the value of FAR in the same cohort. The authors are requested to
validate the significance of FAR in another validation cohort.
assistant