Title: Netrin-1-CD146 and S100A9-CD146 are associated with early stage of lymph node
metastasis in colorectal cancer
Version: 1 Date: 30 Apr 2024
Reviewer's report:
In the present manuscript tilted“Netrin-1-CD146 and S100A9-CD146 are associated with
early stage of lymph node metastasis in colorectal cancer”#the authors have investigated the
relationship between the netrin-1/CD146 axis and S100 proteins in sentinel lymph node, and
revealed a possible new mechanism for vascular metastasis of CRC. Based on the results, they
found that the netrin-1/CD146 and S100A9/CD146 axis in CRC tissues might related with  early
stage of lymph node metastasis, thus providing potential novel channels for blocking lymphatic
metastasis and guiding biomarker discovery in CRC patients. These findings are interesting and
novel, the results are enlightening to peers. In summary, it is recommended to give priority to
publication..
Title: Netrin-1-CD146 and S100A9-CD146 are associated with early stage of lymph node
metastasis in colorectal cancer
Version: 1 Date: 30 Apr 2024
Reviewer's report:
In the present manuscript tilted“Netrin-1-CD146 and S100A9-CD146 are associated with
early stage of lymph node metastasis in colorectal cancer”#the authors have investigated the
relationship between the netrin-1/CD146 axis and S100 proteins in sentinel lymph node, and
revealed a possible new mechanism for vascular metastasis of CRC. Based on the results, they
found that the netrin-1/CD146 and S100A9/CD146 axis in CRC tissues might related with  early
stage of lymph node metastasis, thus providing potential novel channels for blocking lymphatic
metastasis and guiding biomarker discovery in CRC patients. These findings are interesting and
novel, the results are enlightening to peers. In summary, it is recommended to give priority to
publication..
Please review this paper.
user
Title: Netrin-1-CD146 and S100A9-CD146 are associated with early stage of lymph node
metastasis in colorectal cancer
Version: 1 Date: 30 Apr 2024
Reviewer's report:
In the present manuscript tilted“Netrin-1-CD146 and S100A9-CD146 are associated with
early stage of lymph node metastasis in colorectal cancer”#the authors have investigated the
relationship between the netrin-1/CD146 axis and S100 proteins in sentinel lymph node, and
revealed a possible new mechanism for vascular metastasis of CRC. Based on the results, they
found that the netrin-1/CD146 and S100A9/CD146 axis in CRC tissues might related with  early
stage of lymph node metastasis, thus providing potential novel channels for blocking lymphatic
metastasis and guiding biomarker discovery in CRC patients. These findings are interesting and
novel, the results are enlightening to peers. In summary, it is recommended to give priority to
publication..
assistant