Reviewer ’s report  
 
Title: Risk of rebleeding from gastroesophageal varices after initia l treatment with 
cyanoacrylate; a systematic review and pooled analysis.  
 
Version: 0 Date: 06 May 2020  
 
Reviewer: Roberto Catanzaro  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annot ated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
- Line 108: SCOPUS and not SOPUS;  
 
- Line 114: delete the 4 round brackets (((( before cyanoacrylate;  
 
- Line 116: delete 1 round bracket after Terms])) and 2 round brackets (((before adhes *);  
 
- Line 129: meeting and non -meting;  
 
- Table 1: Evrad 2003 (22) - Fourth box - Prapranolol and not Proprenolol;  
 
- Table  1: Tan 2006 (24) - Fourth box: versus and not Vesus;  
 
- Lines 214, 215, 216, 217, 218, 219, 220, 221: standardize et al. or et al (eventually without the 
fixed point) and so also in the whole article;  
 
- Line 230: 7 of and not 7of;  
 
- Lines 255, 257, 349: Ro bles-Medranda and not Robles -medranda;  
 
- Line: 334: delete ; after …hypothesize that; at the end of the line;  
 
- Line 337: cyanoacrylate and not Cyanoacrylate;  
 
- References: order better the bibliographic entries by improving them with a homogeneous 
graphic style (insert the initials in capital letters in all the names of the journals. For example, in 
Line 405: Gastrointestinal Endoscopy Clinics of North America and not Gastrointestinal 
endoscopy clinics of North America. So for almost all the 52 bibliographic entries).  
 
Are the methods appropriate and well described?  
If not, please specify w hat is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require  further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of compet ing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now o r in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents relating  to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I h ave no competing interests  
 
Reviewer Publication Consent. I agree for my report to be made  available under an Open 
Access Creative Commons CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if this 
manuscript is accepted for publication. Any comment s that I do not wish to be included in the 
published report have been included as confidential comments to the editor,  which will not be 
published.If you are not happy for us to publish this report, please contact the edi torial office 
before completing the review.If you wish, you can include your name in your publish ed report. 
Please note you must decide whether to include your name at the start of the process and  confirm 
this decision whenever prompted. If you change your decision later, we will not be abl e to 
publish your name.  
 
I agree to the terms of the CC -BY 4.0 license; please publish my name with my report.  
Reviewer ’s report  
 
Title: Risk of rebleeding from gastroesophageal varices after initia l treatment with 
cyanoacrylate; a systematic review and pooled analysis.  
 
Version: 0 Date: 06 May 2020  
 
Reviewer: Roberto Catanzaro  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annot ated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
- Line 108: SCOPUS and not SOPUS;  
 
- Line 114: delete the 4 round brackets (((( before cyanoacrylate;  
 
- Line 116: delete 1 round bracket after Terms])) and 2 round brackets (((before adhes *);  
 
- Line 129: meeting and non -meting;  
 
- Table 1: Evrad 2003 (22) - Fourth box - Prapranolol and not Proprenolol;  
 
- Table  1: Tan 2006 (24) - Fourth box: versus and not Vesus;  
 
- Lines 214, 215, 216, 217, 218, 219, 220, 221: standardize et al. or et al (eventually without the 
fixed point) and so also in the whole article;  
 
- Line 230: 7 of and not 7of;  
 
- Lines 255, 257, 349: Ro bles-Medranda and not Robles -medranda;  
 
- Line: 334: delete ; after …hypothesize that; at the end of the line;  
 
- Line 337: cyanoacrylate and not Cyanoacrylate;  
 
- References: order better the bibliographic entries by improving them with a homogeneous 
graphic style (insert the initials in capital letters in all the names of the journals. For example, in 
Line 405: Gastrointestinal Endoscopy Clinics of North America and not Gastrointestinal 
endoscopy clinics of North America. So for almost all the 52 bibliographic entries).  
 
Are the methods appropriate and well described?  
If not, please specify w hat is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require  further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of compet ing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now o r in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents relating  to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I h ave no competing interests  
 
Reviewer Publication Consent. I agree for my report to be made  available under an Open 
Access Creative Commons CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if this 
manuscript is accepted for publication. Any comment s that I do not wish to be included in the 
published report have been included as confidential comments to the editor,  which will not be 
published.If you are not happy for us to publish this report, please contact the edi torial office 
before completing the review.If you wish, you can include your name in your publish ed report. 
Please note you must decide whether to include your name at the start of the process and  confirm 
this decision whenever prompted. If you change your decision later, we will not be abl e to 
publish your name.  
 
I agree to the terms of the CC -BY 4.0 license; please publish my name with my report.  
Please review this paper.
user
Reviewer ’s report  
 
Title: Risk of rebleeding from gastroesophageal varices after initia l treatment with 
cyanoacrylate; a systematic review and pooled analysis.  
 
Version: 0 Date: 06 May 2020  
 
Reviewer: Roberto Catanzaro  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annot ated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
- Line 108: SCOPUS and not SOPUS;  
 
- Line 114: delete the 4 round brackets (((( before cyanoacrylate;  
 
- Line 116: delete 1 round bracket after Terms])) and 2 round brackets (((before adhes *);  
 
- Line 129: meeting and non -meting;  
 
- Table 1: Evrad 2003 (22) - Fourth box - Prapranolol and not Proprenolol;  
 
- Table  1: Tan 2006 (24) - Fourth box: versus and not Vesus;  
 
- Lines 214, 215, 216, 217, 218, 219, 220, 221: standardize et al. or et al (eventually without the 
fixed point) and so also in the whole article;  
 
- Line 230: 7 of and not 7of;  
 
- Lines 255, 257, 349: Ro bles-Medranda and not Robles -medranda;  
 
- Line: 334: delete ; after …hypothesize that; at the end of the line;  
 
- Line 337: cyanoacrylate and not Cyanoacrylate;  
 
- References: order better the bibliographic entries by improving them with a homogeneous 
graphic style (insert the initials in capital letters in all the names of the journals. For example, in 
Line 405: Gastrointestinal Endoscopy Clinics of North America and not Gastrointestinal 
endoscopy clinics of North America. So for almost all the 52 bibliographic entries).  
 
Are the methods appropriate and well described?  
If not, please specify w hat is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require  further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of compet ing interests, considering the following questions:  
 
1.  Have you in the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now o r in the future?  
 
2.  Do you hold any stocks or shares in an organisation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents relating  to the content 
of the manuscript?  
 
4.  Have you received reimbursements, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I h ave no competing interests  
 
Reviewer Publication Consent. I agree for my report to be made  available under an Open 
Access Creative Commons CC -BY License ( http://creativecommons.org/licenses/by/4.0 ) if this 
manuscript is accepted for publication. Any comment s that I do not wish to be included in the 
published report have been included as confidential comments to the editor,  which will not be 
published.If you are not happy for us to publish this report, please contact the edi torial office 
before completing the review.If you wish, you can include your name in your publish ed report. 
Please note you must decide whether to include your name at the start of the process and  confirm 
this decision whenever prompted. If you change your decision later, we will not be abl e to 
publish your name.  
 
I agree to the terms of the CC -BY 4.0 license; please publish my name with my report.  
assistant