Reviewer's report
Title:Serum pepsinogen levels are valuable markers for the diagnosis of gastric
diseases in Chinese
Version: 1Date:4 October 2013
Reviewer: Katsunori Iijima
Reviewer's report:
Zhang et al. reported serum pepsinogen level as a valuable marker for the
diagnosis of gastric cancer in Chinese. However, because there have already
been a lot of papers regarding relationship between serum pepsinogen and
gastric cancer risk even from China, I found little interest in the contents of the
paper.
I found the following concerns
1. Combined assessment with pepsinogen and H. pylori infection rather that
pepsinogen alone would be more valuable.
2. It is well-known that serum pepsinogen levels are considerably affected by PPI
intake or H. pylori eradication. Were those subjects excluded from the study.
3. Although the authors discussed the different cutoff values of serum
pepsinogen in different countries, they need to be cautious about considerably
differing measured serum PG values between Western and Eastern kits (Iijima K,
et al. World J Gastroenterol. 2009; 21;15(7):853-9. & Miki K, et al. Dig Endosc.
2009 Apr;21(2):134-5).
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
none
Reviewer's report
Title:Serum pepsinogen levels are valuable markers for the diagnosis of gastric
diseases in Chinese
Version: 1Date:4 October 2013
Reviewer: Katsunori Iijima
Reviewer's report:
Zhang et al. reported serum pepsinogen level as a valuable marker for the
diagnosis of gastric cancer in Chinese. However, because there have already
been a lot of papers regarding relationship between serum pepsinogen and
gastric cancer risk even from China, I found little interest in the contents of the
paper.
I found the following concerns
1. Combined assessment with pepsinogen and H. pylori infection rather that
pepsinogen alone would be more valuable.
2. It is well-known that serum pepsinogen levels are considerably affected by PPI
intake or H. pylori eradication. Were those subjects excluded from the study.
3. Although the authors discussed the different cutoff values of serum
pepsinogen in different countries, they need to be cautious about considerably
differing measured serum PG values between Western and Eastern kits (Iijima K,
et al. World J Gastroenterol. 2009; 21;15(7):853-9. & Miki K, et al. Dig Endosc.
2009 Apr;21(2):134-5).
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
none
Please review this paper.
user
Reviewer's report
Title:Serum pepsinogen levels are valuable markers for the diagnosis of gastric
diseases in Chinese
Version: 1Date:4 October 2013
Reviewer: Katsunori Iijima
Reviewer's report:
Zhang et al. reported serum pepsinogen level as a valuable marker for the
diagnosis of gastric cancer in Chinese. However, because there have already
been a lot of papers regarding relationship between serum pepsinogen and
gastric cancer risk even from China, I found little interest in the contents of the
paper.
I found the following concerns
1. Combined assessment with pepsinogen and H. pylori infection rather that
pepsinogen alone would be more valuable.
2. It is well-known that serum pepsinogen levels are considerably affected by PPI
intake or H. pylori eradication. Were those subjects excluded from the study.
3. Although the authors discussed the different cutoff values of serum
pepsinogen in different countries, they need to be cautious about considerably
differing measured serum PG values between Western and Eastern kits (Iijima K,
et al. World J Gastroenterol. 2009; 21;15(7):853-9. & Miki K, et al. Dig Endosc.
2009 Apr;21(2):134-5).
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
none
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