Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 01 Aug 2024
Reviewer's report:
The overall content of the manuscript is complete, with data from the SEER database for
modeling and its own data for external validation. But there are still some minor issues to be
modified:
1.The nomogram of OS in Figure 3 shows that gender is an independent risk factor for predicting
OS, but the results of the multivariate analysis in Table 3 show no significant difference in
gender.
2.It is recommended to add the external verification section to the flow diagram.
3.The third paragraph of the discussion part mentioned: radiotherapy and chemotherapy were
identified as protective factors in both OS and CSS Nomograms. However, according to the
results of Figure 3 and Figure 5, chemotherapy is a protective factor for OS and CSS, but
radiotherapy is a risk factor for OS, and radiotherapy is meaningless for the prognosis of CSS.
Tables 3 and 4 also confirm the results in the nomograms. The author discussion section does
not consistent with the results of the nomogram and table, and the authors are attention to check
and modify it. If radiotherapy is really a risk factor for OS, this is not consistent with clinical
experience, and the authors should explain it.
Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 01 Aug 2024
Reviewer's report:
The overall content of the manuscript is complete, with data from the SEER database for
modeling and its own data for external validation. But there are still some minor issues to be
modified:
1.The nomogram of OS in Figure 3 shows that gender is an independent risk factor for predicting
OS, but the results of the multivariate analysis in Table 3 show no significant difference in
gender.
2.It is recommended to add the external verification section to the flow diagram.
3.The third paragraph of the discussion part mentioned: radiotherapy and chemotherapy were
identified as protective factors in both OS and CSS Nomograms. However, according to the
results of Figure 3 and Figure 5, chemotherapy is a protective factor for OS and CSS, but
radiotherapy is a risk factor for OS, and radiotherapy is meaningless for the prognosis of CSS.
Tables 3 and 4 also confirm the results in the nomograms. The author discussion section does
not consistent with the results of the nomogram and table, and the authors are attention to check
and modify it. If radiotherapy is really a risk factor for OS, this is not consistent with clinical
experience, and the authors should explain it.
Please review this paper.
user
Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 01 Aug 2024
Reviewer's report:
The overall content of the manuscript is complete, with data from the SEER database for
modeling and its own data for external validation. But there are still some minor issues to be
modified:
1.The nomogram of OS in Figure 3 shows that gender is an independent risk factor for predicting
OS, but the results of the multivariate analysis in Table 3 show no significant difference in
gender.
2.It is recommended to add the external verification section to the flow diagram.
3.The third paragraph of the discussion part mentioned: radiotherapy and chemotherapy were
identified as protective factors in both OS and CSS Nomograms. However, according to the
results of Figure 3 and Figure 5, chemotherapy is a protective factor for OS and CSS, but
radiotherapy is a risk factor for OS, and radiotherapy is meaningless for the prognosis of CSS.
Tables 3 and 4 also confirm the results in the nomograms. The author discussion section does
not consistent with the results of the nomogram and table, and the authors are attention to check
and modify it. If radiotherapy is really a risk factor for OS, this is not consistent with clinical
experience, and the authors should explain it.
assistant