Title: Analysis of the status and risk factors for Helicobacter pylori infection and drug resistance
in the Lianyungang area, China
Version: 2 Date: 20 Jan 2025
Reviewer's report:
This manuscript has been revised according to the reviewers' suggestions, but I have the
following additional recommendations:
1. Based on the previous suggestions, analyzing the mere presence of cagA and vacA genes
offers limited interpretative value for the data. I recommend performing genotype analyses
of cagA and vacA to further elucidate the associations between these genotypes and disease
outcomes.  If conducting this sequencing analysis is not feasible, it should be addressed in the
study's limitations.
2. While the authors have revised Table 2 as suggested, please ensure consistent formatting of
cagA and vacA as gene names throughout the manuscript. Additionally, H. pylori should be
italicized.
Title: Analysis of the status and risk factors for Helicobacter pylori infection and drug resistance
in the Lianyungang area, China
Version: 2 Date: 20 Jan 2025
Reviewer's report:
This manuscript has been revised according to the reviewers' suggestions, but I have the
following additional recommendations:
1. Based on the previous suggestions, analyzing the mere presence of cagA and vacA genes
offers limited interpretative value for the data. I recommend performing genotype analyses
of cagA and vacA to further elucidate the associations between these genotypes and disease
outcomes.  If conducting this sequencing analysis is not feasible, it should be addressed in the
study's limitations.
2. While the authors have revised Table 2 as suggested, please ensure consistent formatting of
cagA and vacA as gene names throughout the manuscript. Additionally, H. pylori should be
italicized.
Please review this paper.
user
Title: Analysis of the status and risk factors for Helicobacter pylori infection and drug resistance
in the Lianyungang area, China
Version: 2 Date: 20 Jan 2025
Reviewer's report:
This manuscript has been revised according to the reviewers' suggestions, but I have the
following additional recommendations:
1. Based on the previous suggestions, analyzing the mere presence of cagA and vacA genes
offers limited interpretative value for the data. I recommend performing genotype analyses
of cagA and vacA to further elucidate the associations between these genotypes and disease
outcomes.  If conducting this sequencing analysis is not feasible, it should be addressed in the
study's limitations.
2. While the authors have revised Table 2 as suggested, please ensure consistent formatting of
cagA and vacA as gene names throughout the manuscript. Additionally, H. pylori should be
italicized.
assistant