Reviewer's report
Title:Preventive Effect of Irsogladine or Omeprazole on NSAIDs-Induced
Esophagitis, Peptic Ulcers, and Small Intestinal Lesions in Humans
Version: 1Date:8 January 2013
Reviewer: Shunji Fujimori
Reviewer's report:
The authors show that irsogladine has a preventive effect for NSAID-induced
small intestinal mucosal injuries. The study design is good. However, there are
many problems especially in the presentation. Please see below.
Major points
1) Manuscript writing is insufficiency. Detail methods and results, sufficient
introduction and discussion should be written down.
2) The paper shows no information of NSAID-induced esophageal injuries. The
study cannot conclude preventive effect of irsogladine for NSAID-induced
esophageal injuries. NSAID-induced esophageal injuries should be written
adequately.
3) English should be brushed up. Please check the paper by native speaker.
Minor points
1) The figure 1 (A, B, C) legends are confused.
2) Why dose the sentence “Neither irsogladine nor omeprazole produce any side
effect” be written in analysis of subjects section? It should be written in another
result section.
3) Tangible data should be written in the results of abstract.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Preventive Effect of Irsogladine or Omeprazole on NSAIDs-Induced
Esophagitis, Peptic Ulcers, and Small Intestinal Lesions in Humans
Version: 1Date:8 January 2013
Reviewer: Shunji Fujimori
Reviewer's report:
The authors show that irsogladine has a preventive effect for NSAID-induced
small intestinal mucosal injuries. The study design is good. However, there are
many problems especially in the presentation. Please see below.
Major points
1) Manuscript writing is insufficiency. Detail methods and results, sufficient
introduction and discussion should be written down.
2) The paper shows no information of NSAID-induced esophageal injuries. The
study cannot conclude preventive effect of irsogladine for NSAID-induced
esophageal injuries. NSAID-induced esophageal injuries should be written
adequately.
3) English should be brushed up. Please check the paper by native speaker.
Minor points
1) The figure 1 (A, B, C) legends are confused.
2) Why dose the sentence “Neither irsogladine nor omeprazole produce any side
effect” be written in analysis of subjects section? It should be written in another
result section.
3) Tangible data should be written in the results of abstract.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Preventive Effect of Irsogladine or Omeprazole on NSAIDs-Induced
Esophagitis, Peptic Ulcers, and Small Intestinal Lesions in Humans
Version: 1Date:8 January 2013
Reviewer: Shunji Fujimori
Reviewer's report:
The authors show that irsogladine has a preventive effect for NSAID-induced
small intestinal mucosal injuries. The study design is good. However, there are
many problems especially in the presentation. Please see below.
Major points
1) Manuscript writing is insufficiency. Detail methods and results, sufficient
introduction and discussion should be written down.
2) The paper shows no information of NSAID-induced esophageal injuries. The
study cannot conclude preventive effect of irsogladine for NSAID-induced
esophageal injuries. NSAID-induced esophageal injuries should be written
adequately.
3) English should be brushed up. Please check the paper by native speaker.
Minor points
1) The figure 1 (A, B, C) legends are confused.
2) Why dose the sentence “Neither irsogladine nor omeprazole produce any side
effect” be written in analysis of subjects section? It should be written in another
result section.
3) Tangible data should be written in the results of abstract.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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