Title: Identification of the angiogenesis related genes for predicting prognosis of patients with
gastric cancer
Version: 1 Date: 19 Dec 2020
Reviewer's report:
The study developed a nine gene signature related to the angiogenesis that can predict overall
survival for GC, which could work as potential biomarkers to predict the prognosis and diagnosis
of GC. But my concerns are as the follows.
1. I noticed that in the multivariate COX analysis, stage, T, N and M were all included. But stage
of GC was evaluated using T, N and M, would it be appropriate to include all of them in the
multivariate COX analysis ? And according to the analysis, T, N and M were not independent
prognostic factors for GC patients.
2. In the nomogram, the corresponding score of RS accounted for a great proportion. In the
study, it seems much more important than AJCC TNM staging system.
3. All the data come from network, it would be better if the validation set was experimental data
from your own clinical center.
Title: Identification of the angiogenesis related genes for predicting prognosis of patients with
gastric cancer
Version: 1 Date: 19 Dec 2020
Reviewer's report:
The study developed a nine gene signature related to the angiogenesis that can predict overall
survival for GC, which could work as potential biomarkers to predict the prognosis and diagnosis
of GC. But my concerns are as the follows.
1. I noticed that in the multivariate COX analysis, stage, T, N and M were all included. But stage
of GC was evaluated using T, N and M, would it be appropriate to include all of them in the
multivariate COX analysis ? And according to the analysis, T, N and M were not independent
prognostic factors for GC patients.
2. In the nomogram, the corresponding score of RS accounted for a great proportion. In the
study, it seems much more important than AJCC TNM staging system.
3. All the data come from network, it would be better if the validation set was experimental data
from your own clinical center.
Please review this paper.
user
Title: Identification of the angiogenesis related genes for predicting prognosis of patients with
gastric cancer
Version: 1 Date: 19 Dec 2020
Reviewer's report:
The study developed a nine gene signature related to the angiogenesis that can predict overall
survival for GC, which could work as potential biomarkers to predict the prognosis and diagnosis
of GC. But my concerns are as the follows.
1. I noticed that in the multivariate COX analysis, stage, T, N and M were all included. But stage
of GC was evaluated using T, N and M, would it be appropriate to include all of them in the
multivariate COX analysis ? And according to the analysis, T, N and M were not independent
prognostic factors for GC patients.
2. In the nomogram, the corresponding score of RS accounted for a great proportion. In the
study, it seems much more important than AJCC TNM staging system.
3. All the data come from network, it would be better if the validation set was experimental data
from your own clinical center.
assistant