Title: Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS
and FIB-4 in NAFLD patients
Version: 2 Date: 06 Sep 2024
Reviewer's report:
Authors are requested to stress a central point that is ...  A limitation in the field of clinical
investigation of sarcopenic patients is the lack of a generally accepted definition coupled with
the difficulty of adopting common diagnostic criteria. This explains the  different prevalence
in various studies, as evident in..Intern Emerg Med. 2023; 18(7): 1887–1895. Published online
2023 Jul 25. doi: 10.1007/s11739-023-03339-z
PMCID: PMC10543607PMID: 37490203
Among confounding factor  (authors should point out all of them and shown the results of various
models) was physical activity evaluated and what ere the results?
in the light that exercise is closely linked to sarcopenia , as evident in...Association of
physical behaviours with sarcopenia in older adults: a systematic review and meta-analysis of
observational studies
Lancet Healthy Longev. 2024; 5:e108-e119.
Also middle aged population can suffer from sarcopenia, as evident in..Association of possible
sarcopenia with major chronic diseases and multimorbidity among middle-aged and older adults:
findings from a national cross-sectional study in China. Geriatr Gerontol Int. 2023;23(12):925–
31. https://doi.org/10.1111/ggi.14720.
Authors should specify the US criteria for diagnosing NAFLD and classify its severity, as well
as the values of cross sectional area of the  rectus femoris for detecting sarcopenia.
Could authors express values with a more precise definition, such as mean+/-SD ,   median (IQ),
percentage and CI of OR  to easy the comprehension of the results in the text and Tables?
Could  authors evidence the serum  Ferritin concentrations in their selected patients and controls?
In the Introduction section, authors are requested to check this sentence and amend it...To
emphasize the importance of metabolic risk factors in the progression of NAFLD an international
panel led by Eslam M.  proposed another term for it, going by metabolic-dysfunction-associated-
fatty-liver-disease (NAFLD)....MAFLD?
In the Discussion section, authors are advised to start summarizing their results and discussing
them, instead of referring to other studies.
There are some  typos that should be amended  in the  text and legend to Table 2
Title: Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS
and FIB-4 in NAFLD patients
Version: 2 Date: 06 Sep 2024
Reviewer's report:
Authors are requested to stress a central point that is ...  A limitation in the field of clinical
investigation of sarcopenic patients is the lack of a generally accepted definition coupled with
the difficulty of adopting common diagnostic criteria. This explains the  different prevalence
in various studies, as evident in..Intern Emerg Med. 2023; 18(7): 1887–1895. Published online
2023 Jul 25. doi: 10.1007/s11739-023-03339-z
PMCID: PMC10543607PMID: 37490203
Among confounding factor  (authors should point out all of them and shown the results of various
models) was physical activity evaluated and what ere the results?
in the light that exercise is closely linked to sarcopenia , as evident in...Association of
physical behaviours with sarcopenia in older adults: a systematic review and meta-analysis of
observational studies
Lancet Healthy Longev. 2024; 5:e108-e119.
Also middle aged population can suffer from sarcopenia, as evident in..Association of possible
sarcopenia with major chronic diseases and multimorbidity among middle-aged and older adults:
findings from a national cross-sectional study in China. Geriatr Gerontol Int. 2023;23(12):925–
31. https://doi.org/10.1111/ggi.14720.
Authors should specify the US criteria for diagnosing NAFLD and classify its severity, as well
as the values of cross sectional area of the  rectus femoris for detecting sarcopenia.
Could authors express values with a more precise definition, such as mean+/-SD ,   median (IQ),
percentage and CI of OR  to easy the comprehension of the results in the text and Tables?
Could  authors evidence the serum  Ferritin concentrations in their selected patients and controls?
In the Introduction section, authors are requested to check this sentence and amend it...To
emphasize the importance of metabolic risk factors in the progression of NAFLD an international
panel led by Eslam M.  proposed another term for it, going by metabolic-dysfunction-associated-
fatty-liver-disease (NAFLD)....MAFLD?
In the Discussion section, authors are advised to start summarizing their results and discussing
them, instead of referring to other studies.
There are some  typos that should be amended  in the  text and legend to Table 2
Please review this paper.
user
Title: Title: Association of sarcopenia with serum ferritin levels and hepatic indices like NFS
and FIB-4 in NAFLD patients
Version: 2 Date: 06 Sep 2024
Reviewer's report:
Authors are requested to stress a central point that is ...  A limitation in the field of clinical
investigation of sarcopenic patients is the lack of a generally accepted definition coupled with
the difficulty of adopting common diagnostic criteria. This explains the  different prevalence
in various studies, as evident in..Intern Emerg Med. 2023; 18(7): 1887–1895. Published online
2023 Jul 25. doi: 10.1007/s11739-023-03339-z
PMCID: PMC10543607PMID: 37490203
Among confounding factor  (authors should point out all of them and shown the results of various
models) was physical activity evaluated and what ere the results?
in the light that exercise is closely linked to sarcopenia , as evident in...Association of
physical behaviours with sarcopenia in older adults: a systematic review and meta-analysis of
observational studies
Lancet Healthy Longev. 2024; 5:e108-e119.
Also middle aged population can suffer from sarcopenia, as evident in..Association of possible
sarcopenia with major chronic diseases and multimorbidity among middle-aged and older adults:
findings from a national cross-sectional study in China. Geriatr Gerontol Int. 2023;23(12):925–
31. https://doi.org/10.1111/ggi.14720.
Authors should specify the US criteria for diagnosing NAFLD and classify its severity, as well
as the values of cross sectional area of the  rectus femoris for detecting sarcopenia.
Could authors express values with a more precise definition, such as mean+/-SD ,   median (IQ),
percentage and CI of OR  to easy the comprehension of the results in the text and Tables?
Could  authors evidence the serum  Ferritin concentrations in their selected patients and controls?
In the Introduction section, authors are requested to check this sentence and amend it...To
emphasize the importance of metabolic risk factors in the progression of NAFLD an international
panel led by Eslam M.  proposed another term for it, going by metabolic-dysfunction-associated-
fatty-liver-disease (NAFLD)....MAFLD?
In the Discussion section, authors are advised to start summarizing their results and discussing
them, instead of referring to other studies.
There are some  typos that should be amended  in the  text and legend to Table 2
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