Title: Extremity risk factors of sepsis for gastrointestinal endoscopy in patients with liver
cirrhosis
Version: 5 Date: 23 Dec 2021
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors responded adequately to all questions except one
concern about criteria for prescription of prophylactic antibiotics in 41 patients of experience
group.
They have made adequate changes in manuscript.
The revised manuscript is good with well highlighted limitations.
REQUESTED REVISIONS:
Inclusion criteria: ""The study included adult patients aged 18-70 years old with ESLD or
hepatocellular carcinoma (HCC)"". Do patients with HCC without liver cirrhosis is included in
the study or presence of cirrhosis is crucial for enrolment?
It would be better if you could clarify criteria for antibiotic prescription in 41 patients in
experience group.
ADDITIONAL REQUESTS/SUGGESTIONS:
Introduction section includes large paragraph about liver transplantation which could be
summarized as it is not the scope of the manuscript."
Title: Extremity risk factors of sepsis for gastrointestinal endoscopy in patients with liver
cirrhosis
Version: 5 Date: 23 Dec 2021
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors responded adequately to all questions except one
concern about criteria for prescription of prophylactic antibiotics in 41 patients of experience
group.
They have made adequate changes in manuscript.
The revised manuscript is good with well highlighted limitations.
REQUESTED REVISIONS:
Inclusion criteria: ""The study included adult patients aged 18-70 years old with ESLD or
hepatocellular carcinoma (HCC)"". Do patients with HCC without liver cirrhosis is included in
the study or presence of cirrhosis is crucial for enrolment?
It would be better if you could clarify criteria for antibiotic prescription in 41 patients in
experience group.
ADDITIONAL REQUESTS/SUGGESTIONS:
Introduction section includes large paragraph about liver transplantation which could be
summarized as it is not the scope of the manuscript."
Please review this paper.
user
Title: Extremity risk factors of sepsis for gastrointestinal endoscopy in patients with liver
cirrhosis
Version: 5 Date: 23 Dec 2021
Reviewer's report:
"PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses one or several
testable research questions? (Brief or other article types: is there a clear objective?)
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with sufficient technical rigor to
allow confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Has the author addressed your concerns sufficiently
for you to now recommend the work as a technically sound contribution? If not, can further
revisions be made to make the work technically sound?
Yes - current version is technically sound
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: The authors responded adequately to all questions except one
concern about criteria for prescription of prophylactic antibiotics in 41 patients of experience
group.
They have made adequate changes in manuscript.
The revised manuscript is good with well highlighted limitations.
REQUESTED REVISIONS:
Inclusion criteria: ""The study included adult patients aged 18-70 years old with ESLD or
hepatocellular carcinoma (HCC)"". Do patients with HCC without liver cirrhosis is included in
the study or presence of cirrhosis is crucial for enrolment?
It would be better if you could clarify criteria for antibiotic prescription in 41 patients in
experience group.
ADDITIONAL REQUESTS/SUGGESTIONS:
Introduction section includes large paragraph about liver transplantation which could be
summarized as it is not the scope of the manuscript."
assistant