Title: The associations between modifiable risk factors and constipation: A comprehensive
Mendelian randomization study
Version: 1 Date: 31 Jul 2024
Reviewer:  Danilo Consalvo
Reviewer's report:
At first glance: I found the revised article full of new information. A large amount of data could
be listed and perhaps included in a book.
With a more careful eye, I advise against analyzing the correlation between GERD and
constipation on the basis of visceral hypersensitivity because the ROMA IV Criteria for
constipation do not include pain and visceral hypersensitivity. Perhaps this important point of the
article could be reanalyzed based on the motility disorder and the relationship between transient
lower esophageal sphincter relaxation (TLESR) and colonic slow bowel movement (SCBM) in
constipation.
Title: The associations between modifiable risk factors and constipation: A comprehensive
Mendelian randomization study
Version: 1 Date: 31 Jul 2024
Reviewer:  Danilo Consalvo
Reviewer's report:
At first glance: I found the revised article full of new information. A large amount of data could
be listed and perhaps included in a book.
With a more careful eye, I advise against analyzing the correlation between GERD and
constipation on the basis of visceral hypersensitivity because the ROMA IV Criteria for
constipation do not include pain and visceral hypersensitivity. Perhaps this important point of the
article could be reanalyzed based on the motility disorder and the relationship between transient
lower esophageal sphincter relaxation (TLESR) and colonic slow bowel movement (SCBM) in
constipation.
Please review this paper.
user
Title: The associations between modifiable risk factors and constipation: A comprehensive
Mendelian randomization study
Version: 1 Date: 31 Jul 2024
Reviewer:  Danilo Consalvo
Reviewer's report:
At first glance: I found the revised article full of new information. A large amount of data could
be listed and perhaps included in a book.
With a more careful eye, I advise against analyzing the correlation between GERD and
constipation on the basis of visceral hypersensitivity because the ROMA IV Criteria for
constipation do not include pain and visceral hypersensitivity. Perhaps this important point of the
article could be reanalyzed based on the motility disorder and the relationship between transient
lower esophageal sphincter relaxation (TLESR) and colonic slow bowel movement (SCBM) in
constipation.
assistant