Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 4Date:13 May 2008
Reviewer: Hiroyuki Kuwano
Reviewer's report:
1. The authors added the sentence in the discussion that “it is possible that the
colon motilin receptors may have reduced affinity for erythromycin compared to
the antral nerves or the expression of motilin receptor may be reduced in the
colon”. Then, the authors concluded that Erythoromycin lacks colon prokinetic
effect in children with chronic constipation evaluated by colon manometry. I
agree with authors’ discussions and conclusion.
However, the authors described that the AUC following erythromycin was
significantly less compared to the fasting phase of the study. Therefore, the
mechanism of this interesting phenomenon would better to be discussed, too.
2. The AUC unit was described in “mmHg”. The AUC revealed the area under the
curve. Is there another AUC unit except “mmHg”?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 4Date:13 May 2008
Reviewer: Hiroyuki Kuwano
Reviewer's report:
1. The authors added the sentence in the discussion that “it is possible that the
colon motilin receptors may have reduced affinity for erythromycin compared to
the antral nerves or the expression of motilin receptor may be reduced in the
colon”. Then, the authors concluded that Erythoromycin lacks colon prokinetic
effect in children with chronic constipation evaluated by colon manometry. I
agree with authors’ discussions and conclusion.
However, the authors described that the AUC following erythromycin was
significantly less compared to the fasting phase of the study. Therefore, the
mechanism of this interesting phenomenon would better to be discussed, too.
2. The AUC unit was described in “mmHg”. The AUC revealed the area under the
curve. Is there another AUC unit except “mmHg”?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Erythromycin Lacks Colon Prokinetic Effect in Children with Functional
Gastrointestinal Disorders, A Retrospective Study
Version: 4Date:13 May 2008
Reviewer: Hiroyuki Kuwano
Reviewer's report:
1. The authors added the sentence in the discussion that “it is possible that the
colon motilin receptors may have reduced affinity for erythromycin compared to
the antral nerves or the expression of motilin receptor may be reduced in the
colon”. Then, the authors concluded that Erythoromycin lacks colon prokinetic
effect in children with chronic constipation evaluated by colon manometry. I
agree with authors’ discussions and conclusion.
However, the authors described that the AUC following erythromycin was
significantly less compared to the fasting phase of the study. Therefore, the
mechanism of this interesting phenomenon would better to be discussed, too.
2. The AUC unit was described in “mmHg”. The AUC revealed the area under the
curve. Is there another AUC unit except “mmHg”?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant