Reviewer ’s report  
 
Title: Magnetic Resonance Enterography, Colonoscopy, and Fecal  Calprotect in correlate in 
colonic Crohn ’s Disease  
 
Version: 1 Date: 20 Oct 2019  
 
Reviewer: Andrea Laghi  
 
Reviewer's report:  
 
This prospective single -center trial enrolled 156 patients with colonic Crohn's Disease, aiming at 
finding correlation between MRI, optical colonos copy and fecal calprotectin. Some manuscript 
improvements are suggested below:  
 
* The aim of the study should be stated only in the last paragraph of the introduction; 
therefore, the section should be modified and all the redundancies cut off.  
 
* The study should be clearly labeled as prospective and the time span should be indicated.  
 
* Image acquisition and image analysis should be put into two separate sections. The image 
analysis sections should also be improved.  
 
* Please provide the proper reference for MaRIA score formula and avoid writing down 
results justifying it in this section.  
 
* Was the MaRIA score only calculated on colonic tracts? How many patients have been 
excluded for lack of colonic disease?  
 
* More details regarding the reach of consensus should be given.  
 
* Results section has multiple two -group comparisons not adequately presented in M&;M 
(stats).  
 
* P12L297 -301: self -celebrating sentences should be avoided, and in any case, they don't 
belong  there.  
 
* The quality of the MRI image is low, please find some better images among patients' 
data.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which contr ols are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recomme nd an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate t he quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you i n the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organi sation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimburse ments, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation t o this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I  agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidentia l comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Magnetic Resonance Enterography, Colonoscopy, and Fecal  Calprotect in correlate in 
colonic Crohn ’s Disease  
 
Version: 1 Date: 20 Oct 2019  
 
Reviewer: Andrea Laghi  
 
Reviewer's report:  
 
This prospective single -center trial enrolled 156 patients with colonic Crohn's Disease, aiming at 
finding correlation between MRI, optical colonos copy and fecal calprotectin. Some manuscript 
improvements are suggested below:  
 
* The aim of the study should be stated only in the last paragraph of the introduction; 
therefore, the section should be modified and all the redundancies cut off.  
 
* The study should be clearly labeled as prospective and the time span should be indicated.  
 
* Image acquisition and image analysis should be put into two separate sections. The image 
analysis sections should also be improved.  
 
* Please provide the proper reference for MaRIA score formula and avoid writing down 
results justifying it in this section.  
 
* Was the MaRIA score only calculated on colonic tracts? How many patients have been 
excluded for lack of colonic disease?  
 
* More details regarding the reach of consensus should be given.  
 
* Results section has multiple two -group comparisons not adequately presented in M&;M 
(stats).  
 
* P12L297 -301: self -celebrating sentences should be avoided, and in any case, they don't 
belong  there.  
 
* The quality of the MRI image is low, please find some better images among patients' 
data.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which contr ols are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recomme nd an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate t he quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you i n the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organi sation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimburse ments, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation t o this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I  agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidentia l comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Magnetic Resonance Enterography, Colonoscopy, and Fecal  Calprotect in correlate in 
colonic Crohn ’s Disease  
 
Version: 1 Date: 20 Oct 2019  
 
Reviewer: Andrea Laghi  
 
Reviewer's report:  
 
This prospective single -center trial enrolled 156 patients with colonic Crohn's Disease, aiming at 
finding correlation between MRI, optical colonos copy and fecal calprotectin. Some manuscript 
improvements are suggested below:  
 
* The aim of the study should be stated only in the last paragraph of the introduction; 
therefore, the section should be modified and all the redundancies cut off.  
 
* The study should be clearly labeled as prospective and the time span should be indicated.  
 
* Image acquisition and image analysis should be put into two separate sections. The image 
analysis sections should also be improved.  
 
* Please provide the proper reference for MaRIA score formula and avoid writing down 
results justifying it in this section.  
 
* Was the MaRIA score only calculated on colonic tracts? How many patients have been 
excluded for lack of colonic disease?  
 
* More details regarding the reach of consensus should be given.  
 
* Results section has multiple two -group comparisons not adequately presented in M&;M 
(stats).  
 
* P12L297 -301: self -celebrating sentences should be avoided, and in any case, they don't 
belong  there.  
 
* The quality of the MRI image is low, please find some better images among patients' 
data.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which contr ols are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recomme nd an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate t he quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1.  Have you i n the past five years received reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2.  Do you hold any stocks or shares in an organi sation t hat may in any way gain or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3.  Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4.  Have you received reimburse ments, fees, funding, or salary from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5.  Do you have any other financial competing interests?  
 
6.  Do you have any non -financial competing interests in relation t o this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I  agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidentia l comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant