Title: Comparison of several blood lipid-related indexes in the screening of non- alcoholic fatty
liver disease in women: A cross-sectional study in the Pearl River Delta region of southern China
Version: 1 Date: 13 Oct 2021
Reviewer's report:
Authors should be congratulated for approaching this interesting topic.
Comments&Suggestions
Authors state that ...
NAFLD is a common metabolic disease mainly characterized by lipid metabolism
disorders....but they should honestly recognise that the inner mechanisms underlying NAFLD
are far from being clarified as evident in.....  J. Clin. Med. 2020, 9(1), 15; https://doi.org/10.3390/
jcm9010015.
thus, using only the lipid profile to better diagnose the NAFLD presence is a little bit reductive.
Authors are kindly requested to comment on this point.
Authors state among the strengths of their work the fact that....more attention was given to
women with NAFLD...., but, unfortunately,  it is male gender that is predominant in NAFLD,
involving much more subjects.
Thus, authors could avoid emphasising this strength.
Why did authors not think of comparing this surrogate marker (CMI) of NAFLD presence with
a common one that is FLI, to establish a better/similar/worse discriminant power?
The AUC of CMI, i.e., 0.744, with  the optimal cut-off point of 0.62 (sensitivity=0.74,
specificity=0.65),
is not that great result, so authors could lessen the emphasis on this results.
Authors state to justify the different value of AUC of CNI in another study  that in their
investigation the T2DM presence was small, i.e., our study enrolled a general population
of women who underwent health examinations, of which only a minority of people had
diabetes....but I have noticed in Table that the percentage of T2DM in NAFLD patients was
nearly 29%, thus not so small.
Authors should  point out this aspect, confronting better data.
Title: Comparison of several blood lipid-related indexes in the screening of non- alcoholic fatty
liver disease in women: A cross-sectional study in the Pearl River Delta region of southern China
Version: 1 Date: 13 Oct 2021
Reviewer's report:
Authors should be congratulated for approaching this interesting topic.
Comments&Suggestions
Authors state that ...
NAFLD is a common metabolic disease mainly characterized by lipid metabolism
disorders....but they should honestly recognise that the inner mechanisms underlying NAFLD
are far from being clarified as evident in.....  J. Clin. Med. 2020, 9(1), 15; https://doi.org/10.3390/
jcm9010015.
thus, using only the lipid profile to better diagnose the NAFLD presence is a little bit reductive.
Authors are kindly requested to comment on this point.
Authors state among the strengths of their work the fact that....more attention was given to
women with NAFLD...., but, unfortunately,  it is male gender that is predominant in NAFLD,
involving much more subjects.
Thus, authors could avoid emphasising this strength.
Why did authors not think of comparing this surrogate marker (CMI) of NAFLD presence with
a common one that is FLI, to establish a better/similar/worse discriminant power?
The AUC of CMI, i.e., 0.744, with  the optimal cut-off point of 0.62 (sensitivity=0.74,
specificity=0.65),
is not that great result, so authors could lessen the emphasis on this results.
Authors state to justify the different value of AUC of CNI in another study  that in their
investigation the T2DM presence was small, i.e., our study enrolled a general population
of women who underwent health examinations, of which only a minority of people had
diabetes....but I have noticed in Table that the percentage of T2DM in NAFLD patients was
nearly 29%, thus not so small.
Authors should  point out this aspect, confronting better data.
Please review this paper.
user
Title: Comparison of several blood lipid-related indexes in the screening of non- alcoholic fatty
liver disease in women: A cross-sectional study in the Pearl River Delta region of southern China
Version: 1 Date: 13 Oct 2021
Reviewer's report:
Authors should be congratulated for approaching this interesting topic.
Comments&Suggestions
Authors state that ...
NAFLD is a common metabolic disease mainly characterized by lipid metabolism
disorders....but they should honestly recognise that the inner mechanisms underlying NAFLD
are far from being clarified as evident in.....  J. Clin. Med. 2020, 9(1), 15; https://doi.org/10.3390/
jcm9010015.
thus, using only the lipid profile to better diagnose the NAFLD presence is a little bit reductive.
Authors are kindly requested to comment on this point.
Authors state among the strengths of their work the fact that....more attention was given to
women with NAFLD...., but, unfortunately,  it is male gender that is predominant in NAFLD,
involving much more subjects.
Thus, authors could avoid emphasising this strength.
Why did authors not think of comparing this surrogate marker (CMI) of NAFLD presence with
a common one that is FLI, to establish a better/similar/worse discriminant power?
The AUC of CMI, i.e., 0.744, with  the optimal cut-off point of 0.62 (sensitivity=0.74,
specificity=0.65),
is not that great result, so authors could lessen the emphasis on this results.
Authors state to justify the different value of AUC of CNI in another study  that in their
investigation the T2DM presence was small, i.e., our study enrolled a general population
of women who underwent health examinations, of which only a minority of people had
diabetes....but I have noticed in Table that the percentage of T2DM in NAFLD patients was
nearly 29%, thus not so small.
Authors should  point out this aspect, confronting better data.
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