Reviewer's report
Title:Transcript levels of different cytokines and chemokines correlate with
clinical and endoscopic activity in ulcerative colitis
Version: 1Date:1 February 2008
Reviewer: Takafumi Ando
Reviewer's report:
They made it clear that low clinical and endoscopic activity was accompanied by
low cytokine levels whereas high CAI and EAI were associated with high cytokine
levels. From their data they concluded that real-time PCR quantification of IL-8,
IP10, MRP14 and MIP2 in colonic biopsies is a simple and valid method for
grading inflammation of intestinal mucosa in UC. IL-8, IP10, MRP14 and MIP2
might be used as biomarkers and thus as an objective tool especially in clinical
trials to evaluate anti-inflammatory and immunomodulatory regimens. However,
the simplest evaluation is CAI, and it does not seem that their method is
advantageous in that we exceed it in the method how their trouble and money
suffer from.
What next?: Reject because scientifically unsound
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Transcript levels of different cytokines and chemokines correlate with
clinical and endoscopic activity in ulcerative colitis
Version: 1Date:1 February 2008
Reviewer: Takafumi Ando
Reviewer's report:
They made it clear that low clinical and endoscopic activity was accompanied by
low cytokine levels whereas high CAI and EAI were associated with high cytokine
levels. From their data they concluded that real-time PCR quantification of IL-8,
IP10, MRP14 and MIP2 in colonic biopsies is a simple and valid method for
grading inflammation of intestinal mucosa in UC. IL-8, IP10, MRP14 and MIP2
might be used as biomarkers and thus as an objective tool especially in clinical
trials to evaluate anti-inflammatory and immunomodulatory regimens. However,
the simplest evaluation is CAI, and it does not seem that their method is
advantageous in that we exceed it in the method how their trouble and money
suffer from.
What next?: Reject because scientifically unsound
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Transcript levels of different cytokines and chemokines correlate with
clinical and endoscopic activity in ulcerative colitis
Version: 1Date:1 February 2008
Reviewer: Takafumi Ando
Reviewer's report:
They made it clear that low clinical and endoscopic activity was accompanied by
low cytokine levels whereas high CAI and EAI were associated with high cytokine
levels. From their data they concluded that real-time PCR quantification of IL-8,
IP10, MRP14 and MIP2 in colonic biopsies is a simple and valid method for
grading inflammation of intestinal mucosa in UC. IL-8, IP10, MRP14 and MIP2
might be used as biomarkers and thus as an objective tool especially in clinical
trials to evaluate anti-inflammatory and immunomodulatory regimens. However,
the simplest evaluation is CAI, and it does not seem that their method is
advantageous in that we exceed it in the method how their trouble and money
suffer from.
What next?: Reject because scientifically unsound
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant