Title: Global, Regional, and National Burden of Colorectal Cancer in the Elderly (Aged >60
Years): A Comprehensive Analysis Across 204 Countries and Territories (1990-2021)
Version: 1 Date: 08 Jun 2025
Reviewer's report:
Thanks for the opportunity to review the manuscript “Global, Regional, and National Burden of
Colon and rectum cancer in the Elderly Across 204 Countries and Territories” by Luo S
The authors wrote a manuscript on global trends in colorectal cancer in elderly patients,
utilizing global burden of disease data, joint point regression analysis, and Bayesian analysis for
projections. I congratulate the authors on putting in the time and effort to produce this important
work. Overall, authors present an important message to convey, that optimizing screening
strategies in the elderly population is a necessity.
Abstract – cite the age interval defining elderly adults in the background, as elderly patients (60
years old and older).
Results: spell BAPC
Figure 4 is incomplete; the variable box “epidemiological…”
In the discussion, the authors note that greater immunotherapy availability in high SDI countries
has a positive impact. However, the use of PD1 inhibitors/immunotherapy is too recent to have
influenced any trends, despite its promise. This warrants a brief acknowledgment.
The authors wrote: “This could result in inaccuracies when estimating the true burden of elderly
hip fractures.” Please rewrite this; the paper is not about hip fractures.
Title: Global, Regional, and National Burden of Colorectal Cancer in the Elderly (Aged >60
Years): A Comprehensive Analysis Across 204 Countries and Territories (1990-2021)
Version: 1 Date: 08 Jun 2025
Reviewer's report:
Thanks for the opportunity to review the manuscript “Global, Regional, and National Burden of
Colon and rectum cancer in the Elderly Across 204 Countries and Territories” by Luo S
The authors wrote a manuscript on global trends in colorectal cancer in elderly patients,
utilizing global burden of disease data, joint point regression analysis, and Bayesian analysis for
projections. I congratulate the authors on putting in the time and effort to produce this important
work. Overall, authors present an important message to convey, that optimizing screening
strategies in the elderly population is a necessity.
Abstract – cite the age interval defining elderly adults in the background, as elderly patients (60
years old and older).
Results: spell BAPC
Figure 4 is incomplete; the variable box “epidemiological…”
In the discussion, the authors note that greater immunotherapy availability in high SDI countries
has a positive impact. However, the use of PD1 inhibitors/immunotherapy is too recent to have
influenced any trends, despite its promise. This warrants a brief acknowledgment.
The authors wrote: “This could result in inaccuracies when estimating the true burden of elderly
hip fractures.” Please rewrite this; the paper is not about hip fractures.
Please review this paper.
user
Title: Global, Regional, and National Burden of Colorectal Cancer in the Elderly (Aged >60
Years): A Comprehensive Analysis Across 204 Countries and Territories (1990-2021)
Version: 1 Date: 08 Jun 2025
Reviewer's report:
Thanks for the opportunity to review the manuscript “Global, Regional, and National Burden of
Colon and rectum cancer in the Elderly Across 204 Countries and Territories” by Luo S
The authors wrote a manuscript on global trends in colorectal cancer in elderly patients,
utilizing global burden of disease data, joint point regression analysis, and Bayesian analysis for
projections. I congratulate the authors on putting in the time and effort to produce this important
work. Overall, authors present an important message to convey, that optimizing screening
strategies in the elderly population is a necessity.
Abstract – cite the age interval defining elderly adults in the background, as elderly patients (60
years old and older).
Results: spell BAPC
Figure 4 is incomplete; the variable box “epidemiological…”
In the discussion, the authors note that greater immunotherapy availability in high SDI countries
has a positive impact. However, the use of PD1 inhibitors/immunotherapy is too recent to have
influenced any trends, despite its promise. This warrants a brief acknowledgment.
The authors wrote: “This could result in inaccuracies when estimating the true burden of elderly
hip fractures.” Please rewrite this; the paper is not about hip fractures.
assistant