Reviewer's report
Title:Klebsiella pneumoniae bacteremia and renosplenic abscesses, without
intestinal symptoms, as the initial manifestations of non-steroidal
anti-inflammatory drug-induced colitis: a case report and literature review
Version: 5Date:7 June 2013
Reviewer: Giovanni Di Nardo
Reviewer's report:
This manuscript is an interesting and well-written manuscript reporting the first
case of disseminated abscess formation caused by community-acquired K.
pneumoniae in kidney and spleen without liver involvement in an NSAID-induced
colitis patient.
Major comments:
1. I think that this manuscript can’t be considered a literature review. I suggest to
cut this affirmation in the title.
2. Specify type of NSAID, dose and duration of the therapy.
3. Speculate in the discussion on the different risk of colitis related to the type of
NSAID.
4. “….wall thickening of sigmoid colon, descending colon, and terminal ileum….”
we need more detail on this TC finding (i.e parietal stratification loss, calibre of
the lumen, contrast enhancement).
5. “…..A colonoscopy revealed diffuse ulceration with exudation at the distal
terminal ileum, segmental ulceration at the colon, with stenotic lumen at the
sigmoid…..”. If the endoscopist was able to pass the stenosis, it’s better to define
reduction in the lumen calibre and not stenosis.
6. “…She led an uneventful course at the OPD, and the follow-up colonoscopy
two years later revealed no ulcer or stenosis over the entire colon...” Why so late,
what about biopsies during this follow-up colonoscopy. This point is crucial to
exclude that we are observing an IBD during a period of endoscopic remission
but with histological signs of quiescent disease.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No conflict of interest to declare
Reviewer's report
Title:Klebsiella pneumoniae bacteremia and renosplenic abscesses, without
intestinal symptoms, as the initial manifestations of non-steroidal
anti-inflammatory drug-induced colitis: a case report and literature review
Version: 5Date:7 June 2013
Reviewer: Giovanni Di Nardo
Reviewer's report:
This manuscript is an interesting and well-written manuscript reporting the first
case of disseminated abscess formation caused by community-acquired K.
pneumoniae in kidney and spleen without liver involvement in an NSAID-induced
colitis patient.
Major comments:
1. I think that this manuscript can’t be considered a literature review. I suggest to
cut this affirmation in the title.
2. Specify type of NSAID, dose and duration of the therapy.
3. Speculate in the discussion on the different risk of colitis related to the type of
NSAID.
4. “….wall thickening of sigmoid colon, descending colon, and terminal ileum….”
we need more detail on this TC finding (i.e parietal stratification loss, calibre of
the lumen, contrast enhancement).
5. “…..A colonoscopy revealed diffuse ulceration with exudation at the distal
terminal ileum, segmental ulceration at the colon, with stenotic lumen at the
sigmoid…..”. If the endoscopist was able to pass the stenosis, it’s better to define
reduction in the lumen calibre and not stenosis.
6. “…She led an uneventful course at the OPD, and the follow-up colonoscopy
two years later revealed no ulcer or stenosis over the entire colon...” Why so late,
what about biopsies during this follow-up colonoscopy. This point is crucial to
exclude that we are observing an IBD during a period of endoscopic remission
but with histological signs of quiescent disease.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No conflict of interest to declare
Please review this paper.
user
Reviewer's report
Title:Klebsiella pneumoniae bacteremia and renosplenic abscesses, without
intestinal symptoms, as the initial manifestations of non-steroidal
anti-inflammatory drug-induced colitis: a case report and literature review
Version: 5Date:7 June 2013
Reviewer: Giovanni Di Nardo
Reviewer's report:
This manuscript is an interesting and well-written manuscript reporting the first
case of disseminated abscess formation caused by community-acquired K.
pneumoniae in kidney and spleen without liver involvement in an NSAID-induced
colitis patient.
Major comments:
1. I think that this manuscript can’t be considered a literature review. I suggest to
cut this affirmation in the title.
2. Specify type of NSAID, dose and duration of the therapy.
3. Speculate in the discussion on the different risk of colitis related to the type of
NSAID.
4. “….wall thickening of sigmoid colon, descending colon, and terminal ileum….”
we need more detail on this TC finding (i.e parietal stratification loss, calibre of
the lumen, contrast enhancement).
5. “…..A colonoscopy revealed diffuse ulceration with exudation at the distal
terminal ileum, segmental ulceration at the colon, with stenotic lumen at the
sigmoid…..”. If the endoscopist was able to pass the stenosis, it’s better to define
reduction in the lumen calibre and not stenosis.
6. “…She led an uneventful course at the OPD, and the follow-up colonoscopy
two years later revealed no ulcer or stenosis over the entire colon...” Why so late,
what about biopsies during this follow-up colonoscopy. This point is crucial to
exclude that we are observing an IBD during a period of endoscopic remission
but with histological signs of quiescent disease.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No conflict of interest to declare
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