Reviewer ’s report  
 
Title: Diffused hepatic angiosarcoma with Kasabach -Merritt synd rome -case report and literature 
review  
 
Version: 0 Date: 15 Oct 2019  
 
Reviewer: Jonathan B. Koea  
 
Reviewer's report:  
This paper describes a case report of an acute presentation in a 56 year male presenting with 
signs of hepatic insufficiency and Kasabach Merr itt syndrome. The initial diagnosis was of a 
giant hemangioma and Kasabach Merritt syndrome and the patient was treated with a liver 
transplant. The final pathology of the explant confirmed primary angiosarcoma and the patient 
died within two months of met astatic disease. The English grammar requires extensive revision 
and the paper needs to have first person references removed ("we introduced"). Although the 
paper is accompanied by a literature review it does not introduce any new information into the 
international literature over and above what is already known about the management of hepatic 
angiosarcoma. Because of this factor it does not reach the threshold for publication.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional  statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain  or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing inte rests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the jo urnal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree fo r my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Diffused hepatic angiosarcoma with Kasabach -Merritt synd rome -case report and literature 
review  
 
Version: 0 Date: 15 Oct 2019  
 
Reviewer: Jonathan B. Koea  
 
Reviewer's report:  
This paper describes a case report of an acute presentation in a 56 year male presenting with 
signs of hepatic insufficiency and Kasabach Merr itt syndrome. The initial diagnosis was of a 
giant hemangioma and Kasabach Merritt syndrome and the patient was treated with a liver 
transplant. The final pathology of the explant confirmed primary angiosarcoma and the patient 
died within two months of met astatic disease. The English grammar requires extensive revision 
and the paper needs to have first person references removed ("we introduced"). Although the 
paper is accompanied by a literature review it does not introduce any new information into the 
international literature over and above what is already known about the management of hepatic 
angiosarcoma. Because of this factor it does not reach the threshold for publication.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional  statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain  or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing inte rests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the jo urnal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree fo r my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Diffused hepatic angiosarcoma with Kasabach -Merritt synd rome -case report and literature 
review  
 
Version: 0 Date: 15 Oct 2019  
 
Reviewer: Jonathan B. Koea  
 
Reviewer's report:  
This paper describes a case report of an acute presentation in a 56 year male presenting with 
signs of hepatic insufficiency and Kasabach Merr itt syndrome. The initial diagnosis was of a 
giant hemangioma and Kasabach Merritt syndrome and the patient was treated with a liver 
transplant. The final pathology of the explant confirmed primary angiosarcoma and the patient 
died within two months of met astatic disease. The English grammar requires extensive revision 
and the paper needs to have first person references removed ("we introduced"). Although the 
paper is accompanied by a literature review it does not introduce any new information into the 
international literature over and above what is already known about the management of hepatic 
angiosarcoma. Because of this factor it does not reach the threshold for publication.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional  statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain  or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing inte rests in relation to this paper?  
 
If you can answer no to al l of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the jo urnal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree fo r my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant