Reviewer’ s report
Title: Value of Routine Test for Identifying Colorectal Cancer from Patients with Nonalcoholic
Fatty Liver Disease
Version: 0Date: 18 Jun 2019
Reviewer: Atsushi Nakajima
Reviewer's report:
This study is aimed to investigate the relationship between NAFLD and colorectal cancer (CRC),
and is dealing with a big data in China. NAFLD is a risk factor for the CRC, and CRC incidenceincreases with age. Furthermore, investigating blood samples such as anemia, liver function, andblood lipid may be useful for detecting CRC in NAFLD patients. This study is highly importantbecause it contributes the prevention of CRC with NAFLD. This is well written study. However, ithas some limitations as follows;Major1. My main concern is that this topic has already reported insome studies, and it seems that this study lacks new findings. 2. The risk of CRC is comparedbetween NAFLD-CRC and NAFLD-NonCRC in patients' age and blood samples. Are there anydifferent tendencies in non NAFLD patients (non NAFLD-CRC vs non NAFLD- NonCRC)against NAFLD patients? I consider the authors should describe it in the discussion section. Ifthere are any findings, this report will be more improved.Minor1. This report states that there aredifferences between NAFLD-CRC and NAFLD-Non CRC in TG, HDL and LDL. As the authordescribed that another report has different result from this study, it is unclear that they are useful ornot for the CRC screening.I hope these comments will be helpful.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
NoAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Reviewer’ s report
Title: Value of Routine Test for Identifying Colorectal Cancer from Patients with Nonalcoholic
Fatty Liver Disease
Version: 0Date: 18 Jun 2019
Reviewer: Atsushi Nakajima
Reviewer's report:
This study is aimed to investigate the relationship between NAFLD and colorectal cancer (CRC),
and is dealing with a big data in China. NAFLD is a risk factor for the CRC, and CRC incidenceincreases with age. Furthermore, investigating blood samples such as anemia, liver function, andblood lipid may be useful for detecting CRC in NAFLD patients. This study is highly importantbecause it contributes the prevention of CRC with NAFLD. This is well written study. However, ithas some limitations as follows;Major1. My main concern is that this topic has already reported insome studies, and it seems that this study lacks new findings. 2. The risk of CRC is comparedbetween NAFLD-CRC and NAFLD-NonCRC in patients' age and blood samples. Are there anydifferent tendencies in non NAFLD patients (non NAFLD-CRC vs non NAFLD- NonCRC)against NAFLD patients? I consider the authors should describe it in the discussion section. Ifthere are any findings, this report will be more improved.Minor1. This report states that there aredifferences between NAFLD-CRC and NAFLD-Non CRC in TG, HDL and LDL. As the authordescribed that another report has different result from this study, it is unclear that they are useful ornot for the CRC screening.I hope these comments will be helpful.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
NoAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’ s report
Title: Value of Routine Test for Identifying Colorectal Cancer from Patients with Nonalcoholic
Fatty Liver Disease
Version: 0Date: 18 Jun 2019
Reviewer: Atsushi Nakajima
Reviewer's report:
This study is aimed to investigate the relationship between NAFLD and colorectal cancer (CRC),
and is dealing with a big data in China. NAFLD is a risk factor for the CRC, and CRC incidenceincreases with age. Furthermore, investigating blood samples such as anemia, liver function, andblood lipid may be useful for detecting CRC in NAFLD patients. This study is highly importantbecause it contributes the prevention of CRC with NAFLD. This is well written study. However, ithas some limitations as follows;Major1. My main concern is that this topic has already reported insome studies, and it seems that this study lacks new findings. 2. The risk of CRC is comparedbetween NAFLD-CRC and NAFLD-NonCRC in patients' age and blood samples. Are there anydifferent tendencies in non NAFLD patients (non NAFLD-CRC vs non NAFLD- NonCRC)against NAFLD patients? I consider the authors should describe it in the discussion section. Ifthere are any findings, this report will be more improved.Minor1. This report states that there aredifferences between NAFLD-CRC and NAFLD-Non CRC in TG, HDL and LDL. As the authordescribed that another report has different result from this study, it is unclear that they are useful ornot for the CRC screening.I hope these comments will be helpful.
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
NoAre the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
AcceptableDeclaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I declare that I have no competing interests.I agree to the open peer review policy of the journal. I understand that my name will be included
on my report to the authors and, if the manuscript is accepted for publication, my named reportincluding any attachments I upload will be posted on the website along with the authors'responses. I agree for my report to be made available under an Open Access Creative CommonsCC-BY license (http://creativecommons.org/licenses/by/4.0/). I understand that any commentswhich I do not wish to be included in my named report can be included as confidential commentsto the editors, which will not be published.
I agree to the open peer review policy of the journal
assistant