Title: Effectiveness of Saccharomyces Boulardii CNCM I-745 Probiotic in Acute Inflammatory
Viral Diarrhoea in Adults. Results of a Randomized Clinical Trial.
Version: 3 Date: 26 Nov 2022
Reviewer's report:
The need for study is established , as probiotic role in  viral diarrhea is not conclusive .
Overall, the study design is fair and seems to be well executed.  The chosen study end points
are not routinely followed, hence the limitations needs to be mentioned
Find below my comments
1)Since the sample size is 47, the title of  study can be renamed as 'Effectiveness of S boulardii
CNCM I 745  probiotic in acute inflammatory viral diarrhea in adults;  results from a single
centre, RCT
2)What is the rationale for administering Sb 600mg per day for 8 days?  please add appropriate
references justifying the same  in 'discussion' section
3)How is the pain severity measured and reported in this study? please enumerate in 'methods '
4)The clinical end points of improvement with patient global impression of  scale does not
capture information on few of standard end points in diarrhea studies such as consistency of
stools, frequency of stools, hydration status, associated symptoms such as nausea and vomiting.
This should be included as limitation of study.
5) Apart from Day 4 and day 8 , it would be good to see daily improvement scores from day 1
to 8. please include this information in supplementary  table if available
6) Which antispasmodics and analgesics are used in study? mention
Title: Effectiveness of Saccharomyces Boulardii CNCM I-745 Probiotic in Acute Inflammatory
Viral Diarrhoea in Adults. Results of a Randomized Clinical Trial.
Version: 3 Date: 26 Nov 2022
Reviewer's report:
The need for study is established , as probiotic role in  viral diarrhea is not conclusive .
Overall, the study design is fair and seems to be well executed.  The chosen study end points
are not routinely followed, hence the limitations needs to be mentioned
Find below my comments
1)Since the sample size is 47, the title of  study can be renamed as 'Effectiveness of S boulardii
CNCM I 745  probiotic in acute inflammatory viral diarrhea in adults;  results from a single
centre, RCT
2)What is the rationale for administering Sb 600mg per day for 8 days?  please add appropriate
references justifying the same  in 'discussion' section
3)How is the pain severity measured and reported in this study? please enumerate in 'methods '
4)The clinical end points of improvement with patient global impression of  scale does not
capture information on few of standard end points in diarrhea studies such as consistency of
stools, frequency of stools, hydration status, associated symptoms such as nausea and vomiting.
This should be included as limitation of study.
5) Apart from Day 4 and day 8 , it would be good to see daily improvement scores from day 1
to 8. please include this information in supplementary  table if available
6) Which antispasmodics and analgesics are used in study? mention
Please review this paper.
user
Title: Effectiveness of Saccharomyces Boulardii CNCM I-745 Probiotic in Acute Inflammatory
Viral Diarrhoea in Adults. Results of a Randomized Clinical Trial.
Version: 3 Date: 26 Nov 2022
Reviewer's report:
The need for study is established , as probiotic role in  viral diarrhea is not conclusive .
Overall, the study design is fair and seems to be well executed.  The chosen study end points
are not routinely followed, hence the limitations needs to be mentioned
Find below my comments
1)Since the sample size is 47, the title of  study can be renamed as 'Effectiveness of S boulardii
CNCM I 745  probiotic in acute inflammatory viral diarrhea in adults;  results from a single
centre, RCT
2)What is the rationale for administering Sb 600mg per day for 8 days?  please add appropriate
references justifying the same  in 'discussion' section
3)How is the pain severity measured and reported in this study? please enumerate in 'methods '
4)The clinical end points of improvement with patient global impression of  scale does not
capture information on few of standard end points in diarrhea studies such as consistency of
stools, frequency of stools, hydration status, associated symptoms such as nausea and vomiting.
This should be included as limitation of study.
5) Apart from Day 4 and day 8 , it would be good to see daily improvement scores from day 1
to 8. please include this information in supplementary  table if available
6) Which antispasmodics and analgesics are used in study? mention
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