Title: Title: Risk factors for long-term survival in patients with ypN+M0 rectal cancer after
radical anterior resection
Version: 1 Date: 05 Sep 2021
Reviewer's report:
This is a retrospective analysis from a single institution where the authors investigated the
risk factors for the long term oncologic outcomes of node positive rectal cancer after curative
treatment.
The study was designed straight-forward and the results were clearly presented.
- Major comment:
* The authors emphasized as a main finding the negative effect of angiotensin-converting
enzyme inhibitors (ACEIs) on the prognosis of rectal cancer based upon their results, which
does not agree previous researches. The relationship between ACEIs and the risk of colorectal
cancer has been widely studies including large population-based studies. The scientific rationale
provided by the authors seems too weak to convert previous consensus.
* Although this is a retrospective study, inclusion / exclusion criteria needs to  be clearly
mentioned. Some of the excluded cases are not clearly explained (eg. APR, ypN1c for LOOD,
LNR and so on). According to the manuscript, during the study period, two different types of
preoperative therapy had been performed, which might influenced on the outcomes and should
have been included to analysis.
- Minor comment:
* It would have been more interesting study, if they had included initial / preoperative radiologic
findings such as mrTN stages, mrTRG, mrEMVI and so on.
Title: Title: Risk factors for long-term survival in patients with ypN+M0 rectal cancer after
radical anterior resection
Version: 1 Date: 05 Sep 2021
Reviewer's report:
This is a retrospective analysis from a single institution where the authors investigated the
risk factors for the long term oncologic outcomes of node positive rectal cancer after curative
treatment.
The study was designed straight-forward and the results were clearly presented.
- Major comment:
* The authors emphasized as a main finding the negative effect of angiotensin-converting
enzyme inhibitors (ACEIs) on the prognosis of rectal cancer based upon their results, which
does not agree previous researches. The relationship between ACEIs and the risk of colorectal
cancer has been widely studies including large population-based studies. The scientific rationale
provided by the authors seems too weak to convert previous consensus.
* Although this is a retrospective study, inclusion / exclusion criteria needs to  be clearly
mentioned. Some of the excluded cases are not clearly explained (eg. APR, ypN1c for LOOD,
LNR and so on). According to the manuscript, during the study period, two different types of
preoperative therapy had been performed, which might influenced on the outcomes and should
have been included to analysis.
- Minor comment:
* It would have been more interesting study, if they had included initial / preoperative radiologic
findings such as mrTN stages, mrTRG, mrEMVI and so on.
Please review this paper.
user
Title: Title: Risk factors for long-term survival in patients with ypN+M0 rectal cancer after
radical anterior resection
Version: 1 Date: 05 Sep 2021
Reviewer's report:
This is a retrospective analysis from a single institution where the authors investigated the
risk factors for the long term oncologic outcomes of node positive rectal cancer after curative
treatment.
The study was designed straight-forward and the results were clearly presented.
- Major comment:
* The authors emphasized as a main finding the negative effect of angiotensin-converting
enzyme inhibitors (ACEIs) on the prognosis of rectal cancer based upon their results, which
does not agree previous researches. The relationship between ACEIs and the risk of colorectal
cancer has been widely studies including large population-based studies. The scientific rationale
provided by the authors seems too weak to convert previous consensus.
* Although this is a retrospective study, inclusion / exclusion criteria needs to  be clearly
mentioned. Some of the excluded cases are not clearly explained (eg. APR, ypN1c for LOOD,
LNR and so on). According to the manuscript, during the study period, two different types of
preoperative therapy had been performed, which might influenced on the outcomes and should
have been included to analysis.
- Minor comment:
* It would have been more interesting study, if they had included initial / preoperative radiologic
findings such as mrTN stages, mrTRG, mrEMVI and so on.
assistant