Title: Building a risk prediction model for anastomotic leakage postoperative low rectal cancer
based on Lasso-Logistic regression
Version: 1 Date: 27 Mar 2025
Reviewer's report:
In this study, the nomogram model for predicting the risk of anastomotic leakage (AL) after low
rectal cancer surgery is discussed.
I recommend that this paper not be accepted without major revision.
Comments:
[1] The factors identified as risk factors for AL in this study have already been reported in
multiple existing studies, and the novelty is lacking. Please consider adding more factors for
analysis (e.g., tumor markers, presence of obstruction, number of rectal resections, and other
novel factors).
[2] Was the matching based on Age and Sex performed due to significant differences? If so,
please create a table comparing the patient background before matching.
[3] The inclusion criteria state "AL cases met the AL diagnostic criteria," but which grade of
cases are included? Is it Grade B or higher?
[4] In the data, are the tumor T stage, tumor N stage, and tumor M stage clinical stages?
[5] Table 2 is difficult to understand. Instead of only listing the results of multivariate analysis,
please create a table that also includes the factors that were input, as mentioned in the text.
[6] Please provide details on Neoadjuvant therapy. Specify whether it was chemotherapy alone
or if radiation therapy was also involved.
Thank you in advance.
Title: Building a risk prediction model for anastomotic leakage postoperative low rectal cancer
based on Lasso-Logistic regression
Version: 1 Date: 27 Mar 2025
Reviewer's report:
In this study, the nomogram model for predicting the risk of anastomotic leakage (AL) after low
rectal cancer surgery is discussed.
I recommend that this paper not be accepted without major revision.
Comments:
[1] The factors identified as risk factors for AL in this study have already been reported in
multiple existing studies, and the novelty is lacking. Please consider adding more factors for
analysis (e.g., tumor markers, presence of obstruction, number of rectal resections, and other
novel factors).
[2] Was the matching based on Age and Sex performed due to significant differences? If so,
please create a table comparing the patient background before matching.
[3] The inclusion criteria state "AL cases met the AL diagnostic criteria," but which grade of
cases are included? Is it Grade B or higher?
[4] In the data, are the tumor T stage, tumor N stage, and tumor M stage clinical stages?
[5] Table 2 is difficult to understand. Instead of only listing the results of multivariate analysis,
please create a table that also includes the factors that were input, as mentioned in the text.
[6] Please provide details on Neoadjuvant therapy. Specify whether it was chemotherapy alone
or if radiation therapy was also involved.
Thank you in advance.
Please review this paper.
user
Title: Building a risk prediction model for anastomotic leakage postoperative low rectal cancer
based on Lasso-Logistic regression
Version: 1 Date: 27 Mar 2025
Reviewer's report:
In this study, the nomogram model for predicting the risk of anastomotic leakage (AL) after low
rectal cancer surgery is discussed.
I recommend that this paper not be accepted without major revision.
Comments:
[1] The factors identified as risk factors for AL in this study have already been reported in
multiple existing studies, and the novelty is lacking. Please consider adding more factors for
analysis (e.g., tumor markers, presence of obstruction, number of rectal resections, and other
novel factors).
[2] Was the matching based on Age and Sex performed due to significant differences? If so,
please create a table comparing the patient background before matching.
[3] The inclusion criteria state "AL cases met the AL diagnostic criteria," but which grade of
cases are included? Is it Grade B or higher?
[4] In the data, are the tumor T stage, tumor N stage, and tumor M stage clinical stages?
[5] Table 2 is difficult to understand. Instead of only listing the results of multivariate analysis,
please create a table that also includes the factors that were input, as mentioned in the text.
[6] Please provide details on Neoadjuvant therapy. Specify whether it was chemotherapy alone
or if radiation therapy was also involved.
Thank you in advance.
assistant