Title: Clinical significance of reactive thrombocytosis in the course of acute pancreatitis
Version: 0 Date: 03 Mar 2023
Reviewer's report:
Thank you for giving me an opportunity to review this manuscript.
There are some concerns that need to be addressed regarding this manuscript.
1. When reading this manuscript, thrombocytopenia seems to have more clinical significance as
thrombocytopenia is related to increased risk of renal dysfunction, cardiovascular dysfunction
and mortality compared to thrombocytosis and normal platelet. I think focus of this manuscript
should be on thrombocytopenia rather than thrombocytosis.
2. I think portion of mild pancreatitis is too small to generalize this result into real clinical
practice. As mentioned in Introduction, portion of severe pancreatitis is estimated to be 25% in
real practice. I think more patients should be included for analysis by extending study period.
3. In table 1, patients were divided into mild and severe group. Which definition did you used
for classification, Atlanta or Japanese? Please state this in table 1 and result section.
4. Table 1 classifies severity into mild and severe. However, in table 2, severity is classified into
mild, moderate, and severe, based on Atlanta classification. It is confusing as both Atlanta and
Japanese classification are used. I think classification should be unified.
5. Abbreviation of “LD” was used first in Line 190. However, full term for “LD” is first used
in line 204. Full term should be used in line 190 for “LD”.
6. At line 204, abbreviation of antithrombin was first used as AT. However, antithrombin is used
without abbreviation in line 288. This should be corrected.
Title: Clinical significance of reactive thrombocytosis in the course of acute pancreatitis
Version: 0 Date: 03 Mar 2023
Reviewer's report:
Thank you for giving me an opportunity to review this manuscript.
There are some concerns that need to be addressed regarding this manuscript.
1. When reading this manuscript, thrombocytopenia seems to have more clinical significance as
thrombocytopenia is related to increased risk of renal dysfunction, cardiovascular dysfunction
and mortality compared to thrombocytosis and normal platelet. I think focus of this manuscript
should be on thrombocytopenia rather than thrombocytosis.
2. I think portion of mild pancreatitis is too small to generalize this result into real clinical
practice. As mentioned in Introduction, portion of severe pancreatitis is estimated to be 25% in
real practice. I think more patients should be included for analysis by extending study period.
3. In table 1, patients were divided into mild and severe group. Which definition did you used
for classification, Atlanta or Japanese? Please state this in table 1 and result section.
4. Table 1 classifies severity into mild and severe. However, in table 2, severity is classified into
mild, moderate, and severe, based on Atlanta classification. It is confusing as both Atlanta and
Japanese classification are used. I think classification should be unified.
5. Abbreviation of “LD” was used first in Line 190. However, full term for “LD” is first used
in line 204. Full term should be used in line 190 for “LD”.
6. At line 204, abbreviation of antithrombin was first used as AT. However, antithrombin is used
without abbreviation in line 288. This should be corrected.
Please review this paper.
user
Title: Clinical significance of reactive thrombocytosis in the course of acute pancreatitis
Version: 0 Date: 03 Mar 2023
Reviewer's report:
Thank you for giving me an opportunity to review this manuscript.
There are some concerns that need to be addressed regarding this manuscript.
1. When reading this manuscript, thrombocytopenia seems to have more clinical significance as
thrombocytopenia is related to increased risk of renal dysfunction, cardiovascular dysfunction
and mortality compared to thrombocytosis and normal platelet. I think focus of this manuscript
should be on thrombocytopenia rather than thrombocytosis.
2. I think portion of mild pancreatitis is too small to generalize this result into real clinical
practice. As mentioned in Introduction, portion of severe pancreatitis is estimated to be 25% in
real practice. I think more patients should be included for analysis by extending study period.
3. In table 1, patients were divided into mild and severe group. Which definition did you used
for classification, Atlanta or Japanese? Please state this in table 1 and result section.
4. Table 1 classifies severity into mild and severe. However, in table 2, severity is classified into
mild, moderate, and severe, based on Atlanta classification. It is confusing as both Atlanta and
Japanese classification are used. I think classification should be unified.
5. Abbreviation of “LD” was used first in Line 190. However, full term for “LD” is first used
in line 204. Full term should be used in line 190 for “LD”.
6. At line 204, abbreviation of antithrombin was first used as AT. However, antithrombin is used
without abbreviation in line 288. This should be corrected.
assistant