Title: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in
inflammatory bowel disease patients
Version: 2 Date: 05 Feb 2024
Reviewer's report:
Dear authors,
IBS and IBD are diseases that can really be confused and overlapping today. I congratulate you
for addressing this issue. However, I have some comments about the article, which you can find
below.
1.It is stated in the article that only patients with a stool count of 3 or more are included. However,
I think it would be necessary to add the concept of time to this number in order to call it chronic
diarrhea. A statement such as the duration of diarrhea is more than 4 weeks can be added to
this section.
2.. Although C. jejuni & Giardiasis were not examined in these patients, it was written in the
discussion section by commenting on the general population. I think that these infectious factors,
which were not examined in the study, should be excluded in the discussion section, and it is
not right to make comments based on their frequency in the general population.
3.The numbers of Crohn's and ulcerative colitis patients are not equal. The question arises
whether the markers examined differ between these diseases. A paragraph can be added to the
discussion section on this topic.
Was a subgroup analysis performed by equalizing the numbers of Crohn's and ulcerative colitis
patients?
4.Since it is inevitable that the use of immunosuppressant drugs will affect the markers, would
it be better if the first diagnosed patients were included in the study?
Why wasn't such a study design considered?
In the study conducted by Pimentel et al., were the patients receiving immunosuppressive
treatment? can be added to the discussion.
Title: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in
inflammatory bowel disease patients
Version: 2 Date: 05 Feb 2024
Reviewer's report:
Dear authors,
IBS and IBD are diseases that can really be confused and overlapping today. I congratulate you
for addressing this issue. However, I have some comments about the article, which you can find
below.
1.It is stated in the article that only patients with a stool count of 3 or more are included. However,
I think it would be necessary to add the concept of time to this number in order to call it chronic
diarrhea. A statement such as the duration of diarrhea is more than 4 weeks can be added to
this section.
2.. Although C. jejuni & Giardiasis were not examined in these patients, it was written in the
discussion section by commenting on the general population. I think that these infectious factors,
which were not examined in the study, should be excluded in the discussion section, and it is
not right to make comments based on their frequency in the general population.
3.The numbers of Crohn's and ulcerative colitis patients are not equal. The question arises
whether the markers examined differ between these diseases. A paragraph can be added to the
discussion section on this topic.
Was a subgroup analysis performed by equalizing the numbers of Crohn's and ulcerative colitis
patients?
4.Since it is inevitable that the use of immunosuppressant drugs will affect the markers, would
it be better if the first diagnosed patients were included in the study?
Why wasn't such a study design considered?
In the study conducted by Pimentel et al., were the patients receiving immunosuppressive
treatment? can be added to the discussion.
Please review this paper.
user
Title: Anti-CdtB and anti-vinculin antibodies to diagnose irritable bowel syndrome in
inflammatory bowel disease patients
Version: 2 Date: 05 Feb 2024
Reviewer's report:
Dear authors,
IBS and IBD are diseases that can really be confused and overlapping today. I congratulate you
for addressing this issue. However, I have some comments about the article, which you can find
below.
1.It is stated in the article that only patients with a stool count of 3 or more are included. However,
I think it would be necessary to add the concept of time to this number in order to call it chronic
diarrhea. A statement such as the duration of diarrhea is more than 4 weeks can be added to
this section.
2.. Although C. jejuni & Giardiasis were not examined in these patients, it was written in the
discussion section by commenting on the general population. I think that these infectious factors,
which were not examined in the study, should be excluded in the discussion section, and it is
not right to make comments based on their frequency in the general population.
3.The numbers of Crohn's and ulcerative colitis patients are not equal. The question arises
whether the markers examined differ between these diseases. A paragraph can be added to the
discussion section on this topic.
Was a subgroup analysis performed by equalizing the numbers of Crohn's and ulcerative colitis
patients?
4.Since it is inevitable that the use of immunosuppressant drugs will affect the markers, would
it be better if the first diagnosed patients were included in the study?
Why wasn't such a study design considered?
In the study conducted by Pimentel et al., were the patients receiving immunosuppressive
treatment? can be added to the discussion.
assistant