Reviewer's report
Title:Relation of cholesterol metabolism to pediatric gallstone disease. A
retrospective controlled study
Version:1Date:5 February 2015
Reviewer: Andrea Cariati
Reviewer's report:
Minor essential revision
Introduction: classification of gallstones please read the article classifiaction of
gallstones in western countries indian j surgery, cariati a. Brown pigment
gallstones could be classified according to the studies of Maki, Cetta (Ann Surg)
Carey Martin and cariati A (indian J surg ).
In the material , calculation: brown pigment gallstones cannot be distinguished
only on the basis of cholesterol content but on the basis of calcium palmitate
content; the majority of gallstones with 10-35% cholesterol, in various studies
(Cetta, carey, Soloway, Cariati) are mixed cholesterol gallstones. Discussion
is too focused on liver syntesis of cholesterol and on squalene etc, please could
enrich discussion reporting the role of intestinal absorbption (see martin carey
works) and the role of local, gallbladder mucosa factors (Cariati A Ultrastructural
patology 2003 and clinical research on hepatology and gastroenterology 2013) .
Finally the role of UGT1A variant has been reported with a modification of
Admiran d and Small triangle on ACES 2014 (Archives of clinical and
experimental surgery).
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Relation of cholesterol metabolism to pediatric gallstone disease. A
retrospective controlled study
Version:1Date:5 February 2015
Reviewer: Andrea Cariati
Reviewer's report:
Minor essential revision
Introduction: classification of gallstones please read the article classifiaction of
gallstones in western countries indian j surgery, cariati a. Brown pigment
gallstones could be classified according to the studies of Maki, Cetta (Ann Surg)
Carey Martin and cariati A (indian J surg ).
In the material , calculation: brown pigment gallstones cannot be distinguished
only on the basis of cholesterol content but on the basis of calcium palmitate
content; the majority of gallstones with 10-35% cholesterol, in various studies
(Cetta, carey, Soloway, Cariati) are mixed cholesterol gallstones. Discussion
is too focused on liver syntesis of cholesterol and on squalene etc, please could
enrich discussion reporting the role of intestinal absorbption (see martin carey
works) and the role of local, gallbladder mucosa factors (Cariati A Ultrastructural
patology 2003 and clinical research on hepatology and gastroenterology 2013) .
Finally the role of UGT1A variant has been reported with a modification of
Admiran d and Small triangle on ACES 2014 (Archives of clinical and
experimental surgery).
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Relation of cholesterol metabolism to pediatric gallstone disease. A
retrospective controlled study
Version:1Date:5 February 2015
Reviewer: Andrea Cariati
Reviewer's report:
Minor essential revision
Introduction: classification of gallstones please read the article classifiaction of
gallstones in western countries indian j surgery, cariati a. Brown pigment
gallstones could be classified according to the studies of Maki, Cetta (Ann Surg)
Carey Martin and cariati A (indian J surg ).
In the material , calculation: brown pigment gallstones cannot be distinguished
only on the basis of cholesterol content but on the basis of calcium palmitate
content; the majority of gallstones with 10-35% cholesterol, in various studies
(Cetta, carey, Soloway, Cariati) are mixed cholesterol gallstones. Discussion
is too focused on liver syntesis of cholesterol and on squalene etc, please could
enrich discussion reporting the role of intestinal absorbption (see martin carey
works) and the role of local, gallbladder mucosa factors (Cariati A Ultrastructural
patology 2003 and clinical research on hepatology and gastroenterology 2013) .
Finally the role of UGT1A variant has been reported with a modification of
Admiran d and Small triangle on ACES 2014 (Archives of clinical and
experimental surgery).
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
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