Title: Evaluating the usefulness of considering the size and morphological type of type B2 vessel
area based on Japan Esophageal Society Classification in estimating tumor invasion depth in
superficial esophageal squamous cell carcinomas: study protocol for a prospective observational
study (Japan BEES study)
Version: 0 Date: 07 Oct 2023
Reviewer's report:
This is a manuscript concerning the protocol to examine whether the extent of B2 vessels
observed by magnifying endoscopy is useful for the diagnosis of invasion depth (MM/SM1).
This is a multicenter study conducted by representative Japanese endoscopists, and reviewer
believe that reliable data will be obtained.
It is stated that 4mm and 10mm are measured using endoscopic instruments, but details of what
kind of instruments are used for the measurement should be described.
We would also like to know whether the reliability of the measured data will be confirmed by
the Central Committee.
Title: Evaluating the usefulness of considering the size and morphological type of type B2 vessel
area based on Japan Esophageal Society Classification in estimating tumor invasion depth in
superficial esophageal squamous cell carcinomas: study protocol for a prospective observational
study (Japan BEES study)
Version: 0 Date: 07 Oct 2023
Reviewer's report:
This is a manuscript concerning the protocol to examine whether the extent of B2 vessels
observed by magnifying endoscopy is useful for the diagnosis of invasion depth (MM/SM1).
This is a multicenter study conducted by representative Japanese endoscopists, and reviewer
believe that reliable data will be obtained.
It is stated that 4mm and 10mm are measured using endoscopic instruments, but details of what
kind of instruments are used for the measurement should be described.
We would also like to know whether the reliability of the measured data will be confirmed by
the Central Committee.
Please review this paper.
user
Title: Evaluating the usefulness of considering the size and morphological type of type B2 vessel
area based on Japan Esophageal Society Classification in estimating tumor invasion depth in
superficial esophageal squamous cell carcinomas: study protocol for a prospective observational
study (Japan BEES study)
Version: 0 Date: 07 Oct 2023
Reviewer's report:
This is a manuscript concerning the protocol to examine whether the extent of B2 vessels
observed by magnifying endoscopy is useful for the diagnosis of invasion depth (MM/SM1).
This is a multicenter study conducted by representative Japanese endoscopists, and reviewer
believe that reliable data will be obtained.
It is stated that 4mm and 10mm are measured using endoscopic instruments, but details of what
kind of instruments are used for the measurement should be described.
We would also like to know whether the reliability of the measured data will be confirmed by
the Central Committee.
assistant