Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do
not contribute to clinical presentation of acquired fructose malabsorption.
Version: 2 Date: 30 Jan 2022
Reviewer:  Zoia Rossokha
Reviewer's report:
Dear Authors!
You provided the article with the original design. A serious clinical study was conducted to select
patients. Molecular genetic analysis is well organized. The article is well written and accessible.
The authors proved the absence of the influence of non-pathogenic gene variants on the acquired
disease. It was the expected result. The authors obtained the same frequencies of gene variants
as in the genomic databases, but they did not confirm this by statistical analysis. The next step of
this study is to compare the frequencies of investigated gene variants in patients with the results
of healthy individuals (may be from the genomic database). The article can be published after
statistical analysis - comparison of the obtained results of the distribution of the studied gene
variants with the results in healthy individuals.
Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do
not contribute to clinical presentation of acquired fructose malabsorption.
Version: 2 Date: 30 Jan 2022
Reviewer:  Zoia Rossokha
Reviewer's report:
Dear Authors!
You provided the article with the original design. A serious clinical study was conducted to select
patients. Molecular genetic analysis is well organized. The article is well written and accessible.
The authors proved the absence of the influence of non-pathogenic gene variants on the acquired
disease. It was the expected result. The authors obtained the same frequencies of gene variants
as in the genomic databases, but they did not confirm this by statistical analysis. The next step of
this study is to compare the frequencies of investigated gene variants in patients with the results
of healthy individuals (may be from the genomic database). The article can be published after
statistical analysis - comparison of the obtained results of the distribution of the studied gene
variants with the results in healthy individuals.
Please review this paper.
user
Title: Gene variants of the SLC2A5 gene encoding GLUT5, the major fructose transporter, do
not contribute to clinical presentation of acquired fructose malabsorption.
Version: 2 Date: 30 Jan 2022
Reviewer:  Zoia Rossokha
Reviewer's report:
Dear Authors!
You provided the article with the original design. A serious clinical study was conducted to select
patients. Molecular genetic analysis is well organized. The article is well written and accessible.
The authors proved the absence of the influence of non-pathogenic gene variants on the acquired
disease. It was the expected result. The authors obtained the same frequencies of gene variants
as in the genomic databases, but they did not confirm this by statistical analysis. The next step of
this study is to compare the frequencies of investigated gene variants in patients with the results
of healthy individuals (may be from the genomic database). The article can be published after
statistical analysis - comparison of the obtained results of the distribution of the studied gene
variants with the results in healthy individuals.
assistant