Reviewer ’s report  
 
Title: GASTROESOPHAGEAL REFLUX DISEASE: PREVALENCE AND EXTRAOESO -
PHAGEAL MANIFESTATIONS AMONG UNDERGRADUATE STUDENTS IN SOUTH  
WEST NIGERIA  
 
Versi on: 2 Date: 27 Jan 2020  
 
Reviewer: Etsuro Yazaki  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be in cluded in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
This manuscript investigated the prevalence of GOR symptoms and its extra oesophageal 
manifestations in Nigeria. The number of subjects was high to assess statis tical significance , and 
peer reviewed questionnaires were used. However, they did not use either endoscopy (although 
the reason was explained in the manuscript) nor pH/MIIpH monitoring to confirm GOR disease, 
which was a significant lack of clinical/scien tific evidence of GORD.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary co ntrols?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statisti cs in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimburse ments, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation t o this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
No to all of the above.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named r eport 
including any attachments I upload will be posted on the website along with the authors' 
responses. I  agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidentia l comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: GASTROESOPHAGEAL REFLUX DISEASE: PREVALENCE AND EXTRAOESO -
PHAGEAL MANIFESTATIONS AMONG UNDERGRADUATE STUDENTS IN SOUTH  
WEST NIGERIA  
 
Versi on: 2 Date: 27 Jan 2020  
 
Reviewer: Etsuro Yazaki  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be in cluded in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
This manuscript investigated the prevalence of GOR symptoms and its extra oesophageal 
manifestations in Nigeria. The number of subjects was high to assess statis tical significance , and 
peer reviewed questionnaires were used. However, they did not use either endoscopy (although 
the reason was explained in the manuscript) nor pH/MIIpH monitoring to confirm GOR disease, 
which was a significant lack of clinical/scien tific evidence of GORD.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary co ntrols?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statisti cs in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimburse ments, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation t o this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
No to all of the above.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named r eport 
including any attachments I upload will be posted on the website along with the authors' 
responses. I  agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidentia l comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: GASTROESOPHAGEAL REFLUX DISEASE: PREVALENCE AND EXTRAOESO -
PHAGEAL MANIFESTATIONS AMONG UNDERGRADUATE STUDENTS IN SOUTH  
WEST NIGERIA  
 
Versi on: 2 Date: 27 Jan 2020  
 
Reviewer: Etsuro Yazaki  
 
Reviewer's report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be in cluded in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
This manuscript investigated the prevalence of GOR symptoms and its extra oesophageal 
manifestations in Nigeria. The number of subjects was high to assess statis tical significance , and 
peer reviewed questionnaires were used. However, they did not use either endoscopy (although 
the reason was explained in the manuscript) nor pH/MIIpH monitoring to confirm GOR disease, 
which was a significant lack of clinical/scien tific evidence of GORD.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary co ntrols?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statisti cs in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimburse ments, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation t o this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
No to all of the above.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named r eport 
including any attachments I upload will be posted on the website along with the authors' 
responses. I  agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidentia l comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant