Reviewer's report
Title:Resveratrol inhibits nonalcoholic fatty liver disease in rats.
Version: 2Date:1 April 2008
Reviewer: Saul Villa-trevi?o
Reviewer's report:
An interesting manuscript is presented related to the effect of resveratrol on
non-alcoholic fatty liver disease (NAFLD). Authors show a clear effect of
resveratrol upon lipid content of liver sections, a clear effect on TNF alpha and
malondialdehide liver level. Additionally they present negative results of
translocation of intestinal bacteria and and the behaviour of transaminases and
glucose.
Major compulsory revisions
It is important to extend discussion on the effect of oxidative stress on the
activation of NFkB and further induction of TNFalpha. (Yinn et al 1999)(kono et
al,2000) (Zhao et al 2008) and conecct these arguments with the known effect of
resveratrol on oxidative stress.
It must be clearly stated in the discussion what is the hypothesis of the
mechanism by which esveratrol decreases liver steatosis in rats.
It should be addressed in the discussion if resveratrol decreases or prevents liver
steatosis.
Minor essential revisions
.Abstract first paragraph line 4, “if resveratrol decrease”; line 5, “in an decrease”;
line 6 “production” shoul be deleted.
Experimental procedures.
Page 4, 3° paragraph “Biopsies”. Is it correct?
Histological evaluation
Page 5, “In the control”,” In” should be deleted.
Discussion
Page 6, line 6, “perosidation and osidation” should be corrected
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Resveratrol inhibits nonalcoholic fatty liver disease in rats.
Version: 2Date:1 April 2008
Reviewer: Saul Villa-trevi?o
Reviewer's report:
An interesting manuscript is presented related to the effect of resveratrol on
non-alcoholic fatty liver disease (NAFLD). Authors show a clear effect of
resveratrol upon lipid content of liver sections, a clear effect on TNF alpha and
malondialdehide liver level. Additionally they present negative results of
translocation of intestinal bacteria and and the behaviour of transaminases and
glucose.
Major compulsory revisions
It is important to extend discussion on the effect of oxidative stress on the
activation of NFkB and further induction of TNFalpha. (Yinn et al 1999)(kono et
al,2000) (Zhao et al 2008) and conecct these arguments with the known effect of
resveratrol on oxidative stress.
It must be clearly stated in the discussion what is the hypothesis of the
mechanism by which esveratrol decreases liver steatosis in rats.
It should be addressed in the discussion if resveratrol decreases or prevents liver
steatosis.
Minor essential revisions
.Abstract first paragraph line 4, “if resveratrol decrease”; line 5, “in an decrease”;
line 6 “production” shoul be deleted.
Experimental procedures.
Page 4, 3° paragraph “Biopsies”. Is it correct?
Histological evaluation
Page 5, “In the control”,” In” should be deleted.
Discussion
Page 6, line 6, “perosidation and osidation” should be corrected
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Resveratrol inhibits nonalcoholic fatty liver disease in rats.
Version: 2Date:1 April 2008
Reviewer: Saul Villa-trevi?o
Reviewer's report:
An interesting manuscript is presented related to the effect of resveratrol on
non-alcoholic fatty liver disease (NAFLD). Authors show a clear effect of
resveratrol upon lipid content of liver sections, a clear effect on TNF alpha and
malondialdehide liver level. Additionally they present negative results of
translocation of intestinal bacteria and and the behaviour of transaminases and
glucose.
Major compulsory revisions
It is important to extend discussion on the effect of oxidative stress on the
activation of NFkB and further induction of TNFalpha. (Yinn et al 1999)(kono et
al,2000) (Zhao et al 2008) and conecct these arguments with the known effect of
resveratrol on oxidative stress.
It must be clearly stated in the discussion what is the hypothesis of the
mechanism by which esveratrol decreases liver steatosis in rats.
It should be addressed in the discussion if resveratrol decreases or prevents liver
steatosis.
Minor essential revisions
.Abstract first paragraph line 4, “if resveratrol decrease”; line 5, “in an decrease”;
line 6 “production” shoul be deleted.
Experimental procedures.
Page 4, 3° paragraph “Biopsies”. Is it correct?
Histological evaluation
Page 5, “In the control”,” In” should be deleted.
Discussion
Page 6, line 6, “perosidation and osidation” should be corrected
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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