Title: Neoadjuvant chemotherapy with or without PD-1/PD-L1 inhibitors in resectable
esophageal squamous cell carcinoma: a meta-analysis based on randomized controlled trials
Version: 1 Date: 13 May 2025
Reviewer's report:
1.
The Methods section should clearly state the definition of OS and EFS.
#The definitions of OS and EFS are clearly stated.
2.
The methods section should provide detailed preoperative neoadjuvant therapy protocols.
#The revised sentence clarifies the details of preoperative neoadjuvant treatment.
3.
Although the pCR and MPR rates were higher in the NIC group than in the NC group, the
number of lymph nodes harvested was significantly higher in the NIC group, potentially leading
to better survival. The question arises as to whether there was any difference in the quality of
surgical procedures between the two groups. What do the authors think about this question?
#I understand the idea that ICI leads to a favorable tumor microenvironment, which may
increase the number of lymph node dissections. Since surgery time, blood loss, and postoperative
complications were not significantly different, it can be inferred that there are no obvious
differences in the quality of surgery.
Title: Neoadjuvant chemotherapy with or without PD-1/PD-L1 inhibitors in resectable
esophageal squamous cell carcinoma: a meta-analysis based on randomized controlled trials
Version: 1 Date: 13 May 2025
Reviewer's report:
1.
The Methods section should clearly state the definition of OS and EFS.
#The definitions of OS and EFS are clearly stated.
2.
The methods section should provide detailed preoperative neoadjuvant therapy protocols.
#The revised sentence clarifies the details of preoperative neoadjuvant treatment.
3.
Although the pCR and MPR rates were higher in the NIC group than in the NC group, the
number of lymph nodes harvested was significantly higher in the NIC group, potentially leading
to better survival. The question arises as to whether there was any difference in the quality of
surgical procedures between the two groups. What do the authors think about this question?
#I understand the idea that ICI leads to a favorable tumor microenvironment, which may
increase the number of lymph node dissections. Since surgery time, blood loss, and postoperative
complications were not significantly different, it can be inferred that there are no obvious
differences in the quality of surgery.
Please review this paper.
user
Title: Neoadjuvant chemotherapy with or without PD-1/PD-L1 inhibitors in resectable
esophageal squamous cell carcinoma: a meta-analysis based on randomized controlled trials
Version: 1 Date: 13 May 2025
Reviewer's report:
1.
The Methods section should clearly state the definition of OS and EFS.
#The definitions of OS and EFS are clearly stated.
2.
The methods section should provide detailed preoperative neoadjuvant therapy protocols.
#The revised sentence clarifies the details of preoperative neoadjuvant treatment.
3.
Although the pCR and MPR rates were higher in the NIC group than in the NC group, the
number of lymph nodes harvested was significantly higher in the NIC group, potentially leading
to better survival. The question arises as to whether there was any difference in the quality of
surgical procedures between the two groups. What do the authors think about this question?
#I understand the idea that ICI leads to a favorable tumor microenvironment, which may
increase the number of lymph node dissections. Since surgery time, blood loss, and postoperative
complications were not significantly different, it can be inferred that there are no obvious
differences in the quality of surgery.
assistant