Reviewer ’s report  
Title: Pancreas grafts for transplantation from donors with h ypertension: An analysis of the 
Scientific Registry of Transplant Recipients database  
 
Version: 2 Date: 26 Jun 2018  
 
Reviewer: Cristina Silvestre  
 
Reviewer's report:  
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as  attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
Background: line 4 "It has been ac cepted diffusely that pancreas transplantation could be a 
considerable alternative to continued insulin therapy..." also islet transplantation is a good option 
for patients with type 1 diabetes; islet transplantation has become increasingly safe and effect ive 
in stabilizing glycemic control in long -term, normalizing HbA1c and lowering the risk of 
secondary complications in patients with type 1 diabetes. Recent advances in islet transplantation 
have markedly improved the 5 -year insulin independence rates, wh ich in several independent 
centers is reported around 50%, placing islet transplantation, on a par with vascularized pancreas 
transplant alone.  
I do believe the authors sholud mention this therapeutic option at some point in the background 
of the paper.  
 
Table 1: Donors characteristics like ICU stay; Cardiac arrest; Serum Creatinine and Estimated 
GFR, Vasopressor use: should be describe in the table and in the paper.  
 
The description of the results should be improved for example with a table that showing: cause 
of death of the patient, cause of graft loss, surgical complications etc. in the two groups  
 
Background: page 4 line 1: cadaveric donor should be replaced with d eceased  
Background: page 4 line 5:"effect impressed on": correct  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supported  by the data shown?  
If not, please explain in your comments to the authors.  
No 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please spec ify what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or  lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future ? 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
Title: Pancreas grafts for transplantation from donors with h ypertension: An analysis of the 
Scientific Registry of Transplant Recipients database  
 
Version: 2 Date: 26 Jun 2018  
 
Reviewer: Cristina Silvestre  
 
Reviewer's report:  
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as  attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
Background: line 4 "It has been ac cepted diffusely that pancreas transplantation could be a 
considerable alternative to continued insulin therapy..." also islet transplantation is a good option 
for patients with type 1 diabetes; islet transplantation has become increasingly safe and effect ive 
in stabilizing glycemic control in long -term, normalizing HbA1c and lowering the risk of 
secondary complications in patients with type 1 diabetes. Recent advances in islet transplantation 
have markedly improved the 5 -year insulin independence rates, wh ich in several independent 
centers is reported around 50%, placing islet transplantation, on a par with vascularized pancreas 
transplant alone.  
I do believe the authors sholud mention this therapeutic option at some point in the background 
of the paper.  
 
Table 1: Donors characteristics like ICU stay; Cardiac arrest; Serum Creatinine and Estimated 
GFR, Vasopressor use: should be describe in the table and in the paper.  
 
The description of the results should be improved for example with a table that showing: cause 
of death of the patient, cause of graft loss, surgical complications etc. in the two groups  
 
Background: page 4 line 1: cadaveric donor should be replaced with d eceased  
Background: page 4 line 5:"effect impressed on": correct  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supported  by the data shown?  
If not, please explain in your comments to the authors.  
No 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please spec ify what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or  lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future ? 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
Title: Pancreas grafts for transplantation from donors with h ypertension: An analysis of the 
Scientific Registry of Transplant Recipients database  
 
Version: 2 Date: 26 Jun 2018  
 
Reviewer: Cristina Silvestre  
 
Reviewer's report:  
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as  attachments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
Background: line 4 "It has been ac cepted diffusely that pancreas transplantation could be a 
considerable alternative to continued insulin therapy..." also islet transplantation is a good option 
for patients with type 1 diabetes; islet transplantation has become increasingly safe and effect ive 
in stabilizing glycemic control in long -term, normalizing HbA1c and lowering the risk of 
secondary complications in patients with type 1 diabetes. Recent advances in islet transplantation 
have markedly improved the 5 -year insulin independence rates, wh ich in several independent 
centers is reported around 50%, placing islet transplantation, on a par with vascularized pancreas 
transplant alone.  
I do believe the authors sholud mention this therapeutic option at some point in the background 
of the paper.  
 
Table 1: Donors characteristics like ICU stay; Cardiac arrest; Serum Creatinine and Estimated 
GFR, Vasopressor use: should be describe in the table and in the paper.  
 
The description of the results should be improved for example with a table that showing: cause 
of death of the patient, cause of graft loss, surgical complications etc. in the two groups  
 
Background: page 4 line 1: cadaveric donor should be replaced with d eceased  
Background: page 4 line 5:"effect impressed on": correct  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supported  by the data shown?  
If not, please explain in your comments to the authors.  
No 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please spec ify what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Acceptable  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or  lose financial ly from the publication of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future ? 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant