Reviewer’ s report
Title: Retroperitoneal Laparoscopic Hepatectomy of Recurrent Hepatocellular Carcinoma: Case
Report and Literature Review
Version: 1Date: 20 Jun 2020
Reviewer: Antonio Calvo
Reviewer's report:
Response to authors:1.Title.
According to the change of the title. It is more appropriate concerning the case presented by theauthors.
2.Recurrent hepatocellular carcinoma
There has been a recurrence of the disease two years after the first surgery. I do not know if theauthors considered the risk factors in the piece resected in the first surgery, which would haveprovided valuable information on the prognosis of the disease, and perhaps, at that time, had beenincluded in the liver transplant program. The reviewer does not judge the considerations betweenthe medical team, the patient, and the family about the final therapeutic decision.
3. Surgical Information
Laparoscopic retroperitoneal hepatectomy is a safe method that can be applied to the partialresection of small and superﬁcial tumors of the right posterior segment of the liver, however, it is
not a valid and universal treatment option for all tumors.
Yes, it is true that in the manuscript it is mentioned that the retroperitoneum is cut into theperitoneal cavity, but authors should indicate in the conclusions of the abstract that the surgicalprocedure is not pure retroperitoneal access.
4- Discussion
I think that there is an excess of data in the discussion of laparoscopic liver procedures, and thefundamental objective of the case is the retroperitoneal approach for the surgical treatment of thistumor.
5. Pathology
Thank you for the correction. Indeed this image corresponds to the pathological descriptionincluded in the text.
6. Reference
Although it has removed some bibliographic references, they are excessive. The subject theypresent is the retroperitoneal approach, which is interesting for being novel and gives interest tothe case presented, but the excess of information and bibliographic citations on the development of
laparoscopic surgery should consider reducing.
Citations must be in black, although the editor will consider it.
Publons Reviewer Recognition. Springer Nature can send verification of this review directly to
Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service,please click on the “Yes” option below. Your name, email address, title of the reviewed
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YesAre the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I have no competing interets belowReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-
script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
Reviewer’ s report
Title: Retroperitoneal Laparoscopic Hepatectomy of Recurrent Hepatocellular Carcinoma: Case
Report and Literature Review
Version: 1Date: 20 Jun 2020
Reviewer: Antonio Calvo
Reviewer's report:
Response to authors:1.Title.
According to the change of the title. It is more appropriate concerning the case presented by theauthors.
2.Recurrent hepatocellular carcinoma
There has been a recurrence of the disease two years after the first surgery. I do not know if theauthors considered the risk factors in the piece resected in the first surgery, which would haveprovided valuable information on the prognosis of the disease, and perhaps, at that time, had beenincluded in the liver transplant program. The reviewer does not judge the considerations betweenthe medical team, the patient, and the family about the final therapeutic decision.
3. Surgical Information
Laparoscopic retroperitoneal hepatectomy is a safe method that can be applied to the partialresection of small and superﬁcial tumors of the right posterior segment of the liver, however, it is
not a valid and universal treatment option for all tumors.
Yes, it is true that in the manuscript it is mentioned that the retroperitoneum is cut into theperitoneal cavity, but authors should indicate in the conclusions of the abstract that the surgicalprocedure is not pure retroperitoneal access.
4- Discussion
I think that there is an excess of data in the discussion of laparoscopic liver procedures, and thefundamental objective of the case is the retroperitoneal approach for the surgical treatment of thistumor.
5. Pathology
Thank you for the correction. Indeed this image corresponds to the pathological descriptionincluded in the text.
6. Reference
Although it has removed some bibliographic references, they are excessive. The subject theypresent is the retroperitoneal approach, which is interesting for being novel and gives interest tothe case presented, but the excess of information and bibliographic citations on the development of
laparoscopic surgery should consider reducing.
Citations must be in black, although the editor will consider it.
Publons Reviewer Recognition. Springer Nature can send verification of this review directly to
Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service,please click on the “Yes” option below. Your name, email address, title of the reviewed
manuscript, name of the journal, and date of your review submission (the “Review Data”) will
then be transmitted to Publons upon publication of the manuscript. If you have already registeredat Publons, they will notify you of the receipt of this review and update your profile as per your
settings and their policy. If you are not registered with Publons, you will receive an email from
them asking you to register in order for them to be able to recognize your review on your newprofile page. Publons may use the Review Data to generate derivative metadata for the benefit ofPublons and you as a reviewer, carefully considering the sensitivity of such information. Forexample, Publons may verify your record as a reviewer by updating your profile published on itswebservice if you have registered for such service or help editors to identify candidate reviewers.Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms
YesAre the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I have no competing interets belowReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-
script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
Please review this paper.
user
Reviewer’ s report
Title: Retroperitoneal Laparoscopic Hepatectomy of Recurrent Hepatocellular Carcinoma: Case
Report and Literature Review
Version: 1Date: 20 Jun 2020
Reviewer: Antonio Calvo
Reviewer's report:
Response to authors:1.Title.
According to the change of the title. It is more appropriate concerning the case presented by theauthors.
2.Recurrent hepatocellular carcinoma
There has been a recurrence of the disease two years after the first surgery. I do not know if theauthors considered the risk factors in the piece resected in the first surgery, which would haveprovided valuable information on the prognosis of the disease, and perhaps, at that time, had beenincluded in the liver transplant program. The reviewer does not judge the considerations betweenthe medical team, the patient, and the family about the final therapeutic decision.
3. Surgical Information
Laparoscopic retroperitoneal hepatectomy is a safe method that can be applied to the partialresection of small and superﬁcial tumors of the right posterior segment of the liver, however, it is
not a valid and universal treatment option for all tumors.
Yes, it is true that in the manuscript it is mentioned that the retroperitoneum is cut into theperitoneal cavity, but authors should indicate in the conclusions of the abstract that the surgicalprocedure is not pure retroperitoneal access.
4- Discussion
I think that there is an excess of data in the discussion of laparoscopic liver procedures, and thefundamental objective of the case is the retroperitoneal approach for the surgical treatment of thistumor.
5. Pathology
Thank you for the correction. Indeed this image corresponds to the pathological descriptionincluded in the text.
6. Reference
Although it has removed some bibliographic references, they are excessive. The subject theypresent is the retroperitoneal approach, which is interesting for being novel and gives interest tothe case presented, but the excess of information and bibliographic citations on the development of
laparoscopic surgery should consider reducing.
Citations must be in black, although the editor will consider it.
Publons Reviewer Recognition. Springer Nature can send verification of this review directly to
Publons (a subsidiary of Clarivate Analytics). If you would like to take advantage of this service,please click on the “Yes” option below. Your name, email address, title of the reviewed
manuscript, name of the journal, and date of your review submission (the “Review Data”) will
then be transmitted to Publons upon publication of the manuscript. If you have already registeredat Publons, they will notify you of the receipt of this review and update your profile as per your
settings and their policy. If you are not registered with Publons, you will receive an email from
them asking you to register in order for them to be able to recognize your review on your newprofile page. Publons may use the Review Data to generate derivative metadata for the benefit ofPublons and you as a reviewer, carefully considering the sensitivity of such information. Forexample, Publons may verify your record as a reviewer by updating your profile published on itswebservice if you have registered for such service or help editors to identify candidate reviewers.Please find the details of processing in Publons’ privacy policy https://publons.com/about/terms
YesAre the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
YesDoes the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Unable to assess
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
YesAre you able to assess any statistics in the manuscript or would you recommend an
additional statistical review?If an additional statistical review is recommended, please specify what aspects require furtherassessment in your comments to the editors.
Not relevant to this manuscriptQuality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an
organisation that may in any way gain or lose financially from the publication of thismanuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose
financially from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds
or has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below.
If your reply is yes to any, please give details below.
I have no competing interets belowReviewer Publication Consent. I agree for my report to be made available under an Open Access
Creative Commons CC-BY License (http://creativecommons.org/licenses/by/4.0) if this manu-
script is accepted for publication. Any comments that I do not wish to be included in the published
report have been included as confidential comments to the editor, which will not be published.Ifyou are not happy for us to publish this report, please contact the editorial office before completingthe review.If you wish, you can include your name in your published report. Please note you mustdecide whether to include your name at the start of the process and confirm this decision wheneverprompted. If you change your decision later, we will not be able to publish your name.
I agree to the terms of the CC-BY 4.0 license; please publish my name with my report.
assistant