Title: The pertinence of gastric cancer and interleukin 10-819 single nucleotide polymorphisms:
a meta-analysis and systematic review
Version: 1 Date: 16 Nov 2023
Reviewer:  Reza Alizadeh-Navaei
Reviewer's report:
This study investigates the association between gastric cancer and a single nucleotide
polymorphism (SNP) of interleukin-10 (IL-10) promoter -819 (rs1800871) through a meta-
analysis. The authors retrieved relevant articles from various databases up to March 2022 and
analyzed data from 15 articles, including a total of 7779 patients. The study found no correlation
between gastric cancer and IL-10 -819 in the recessive, co-dominant, or dominant models, but,
in the allelic model, there was a significant correlation between gastric cancer and IL-10 -819.
The authors emphasize the need for more large cohort studies to confirm these results. However
there were some minor comments for this manuscript:
1- Field of search strategy was not mentioned.
2- In statistical section, Authors mentioned, "Mean difference (MD) was generated as effect-
size for continuous variants" this despite the fact that, there was not any related finding in result
section. Additionaly, authors in result say that " Publication bias is qualitatively tested by funnel
chart, and quantitatively estimated by Begg and Egger's tests. No significant asymmetry was
observed in the funnel chart, which indicated that our findings were not affected by publication
bias" but in statistical section they say that " Publication bias was assessed by Egger’s test". This
inconsistency needs edition.
3- Number of document from each database should be added in Prisma flowchart.
4- NOS score of each individual study should be added in table 1.
5- It seems that authors extract crude rate, additionally, they must be extract and analysis the
adjusted OR for related variables.
Title: The pertinence of gastric cancer and interleukin 10-819 single nucleotide polymorphisms:
a meta-analysis and systematic review
Version: 1 Date: 16 Nov 2023
Reviewer:  Reza Alizadeh-Navaei
Reviewer's report:
This study investigates the association between gastric cancer and a single nucleotide
polymorphism (SNP) of interleukin-10 (IL-10) promoter -819 (rs1800871) through a meta-
analysis. The authors retrieved relevant articles from various databases up to March 2022 and
analyzed data from 15 articles, including a total of 7779 patients. The study found no correlation
between gastric cancer and IL-10 -819 in the recessive, co-dominant, or dominant models, but,
in the allelic model, there was a significant correlation between gastric cancer and IL-10 -819.
The authors emphasize the need for more large cohort studies to confirm these results. However
there were some minor comments for this manuscript:
1- Field of search strategy was not mentioned.
2- In statistical section, Authors mentioned, "Mean difference (MD) was generated as effect-
size for continuous variants" this despite the fact that, there was not any related finding in result
section. Additionaly, authors in result say that " Publication bias is qualitatively tested by funnel
chart, and quantitatively estimated by Begg and Egger's tests. No significant asymmetry was
observed in the funnel chart, which indicated that our findings were not affected by publication
bias" but in statistical section they say that " Publication bias was assessed by Egger’s test". This
inconsistency needs edition.
3- Number of document from each database should be added in Prisma flowchart.
4- NOS score of each individual study should be added in table 1.
5- It seems that authors extract crude rate, additionally, they must be extract and analysis the
adjusted OR for related variables.
Please review this paper.
user
Title: The pertinence of gastric cancer and interleukin 10-819 single nucleotide polymorphisms:
a meta-analysis and systematic review
Version: 1 Date: 16 Nov 2023
Reviewer:  Reza Alizadeh-Navaei
Reviewer's report:
This study investigates the association between gastric cancer and a single nucleotide
polymorphism (SNP) of interleukin-10 (IL-10) promoter -819 (rs1800871) through a meta-
analysis. The authors retrieved relevant articles from various databases up to March 2022 and
analyzed data from 15 articles, including a total of 7779 patients. The study found no correlation
between gastric cancer and IL-10 -819 in the recessive, co-dominant, or dominant models, but,
in the allelic model, there was a significant correlation between gastric cancer and IL-10 -819.
The authors emphasize the need for more large cohort studies to confirm these results. However
there were some minor comments for this manuscript:
1- Field of search strategy was not mentioned.
2- In statistical section, Authors mentioned, "Mean difference (MD) was generated as effect-
size for continuous variants" this despite the fact that, there was not any related finding in result
section. Additionaly, authors in result say that " Publication bias is qualitatively tested by funnel
chart, and quantitatively estimated by Begg and Egger's tests. No significant asymmetry was
observed in the funnel chart, which indicated that our findings were not affected by publication
bias" but in statistical section they say that " Publication bias was assessed by Egger’s test". This
inconsistency needs edition.
3- Number of document from each database should be added in Prisma flowchart.
4- NOS score of each individual study should be added in table 1.
5- It seems that authors extract crude rate, additionally, they must be extract and analysis the
adjusted OR for related variables.
assistant