Title: Validity of rapid urease test using swab of gastric mucus to mucosal forceps and 13C-
urease breath test: a multicenter prospective observational study
Version: 1 Date: 30 May 2024
Reviewer's report:
1. Line 96-98 Please explain the accuracy of diagnosing H. pylori according to the Kyoto
classification. Can it replace histology?
2. Please explain why not all subjects should undergo swab-RUT, forcep-RUT, and UBT. Since
UBT is used as the reference value, there should be no need to divide them into two groups.
3. For the group of susp. H. pylori infection, how to confirm H. pylori infection? The previous
study used histology, UBT, stool Ag test and RUT to diagnose H. pylori infection (at least 2
methods) (JRMS-16-1097)
Title: Validity of rapid urease test using swab of gastric mucus to mucosal forceps and 13C-
urease breath test: a multicenter prospective observational study
Version: 1 Date: 30 May 2024
Reviewer's report:
1. Line 96-98 Please explain the accuracy of diagnosing H. pylori according to the Kyoto
classification. Can it replace histology?
2. Please explain why not all subjects should undergo swab-RUT, forcep-RUT, and UBT. Since
UBT is used as the reference value, there should be no need to divide them into two groups.
3. For the group of susp. H. pylori infection, how to confirm H. pylori infection? The previous
study used histology, UBT, stool Ag test and RUT to diagnose H. pylori infection (at least 2
methods) (JRMS-16-1097)
Please review this paper.
user
Title: Validity of rapid urease test using swab of gastric mucus to mucosal forceps and 13C-
urease breath test: a multicenter prospective observational study
Version: 1 Date: 30 May 2024
Reviewer's report:
1. Line 96-98 Please explain the accuracy of diagnosing H. pylori according to the Kyoto
classification. Can it replace histology?
2. Please explain why not all subjects should undergo swab-RUT, forcep-RUT, and UBT. Since
UBT is used as the reference value, there should be no need to divide them into two groups.
3. For the group of susp. H. pylori infection, how to confirm H. pylori infection? The previous
study used histology, UBT, stool Ag test and RUT to diagnose H. pylori infection (at least 2
methods) (JRMS-16-1097)
assistant