Reviewer's report 
 Generic and Disease-Specific Health Related Quality of Life in Non-cirrhotic, Cirrhotic and Title: 
Transplanted Liver Patients: a cross-sectional study. 
 2  6 September 2003 Version: Date: 
 john C bucuvalas Reviewer: 
Reviewer's report: 
General 
The report is comprehensive and examines a large population of patients with a wide range of liver disease. The information presented is of interest to hepatologists, policy makers, patients and families. 
Discretionary Revisions (which the author can choose to ignore) 
1. The definition used to identify NC and CC are not based on established criteria. Might a simple classification scheme like the Childs-pugh measure be applied 
2. The symptoms addressed in the final figure do not include any of the potential side effects of 
immunosuppressive medication. In future studies, it might be worthwhile to address specifically the effects of these medications on quality of life 
Minor Compulsory Revisions (such as missing labels on figures, or the wrong use of a term, which 
the author can be trusted to correct) 1. The color of the bars for liver transplant recipients in figures 1 and 4 are inconsistent 2. Throughout the report, there are errors in grammar. Close proofreading is 
recommended.(examples) 
3. Were the clinical conditions of those who did not respond different from the respondents, a potential area of bias. 
page 14 
compensated cirrhotic patients may be a symptomatic for years or decades: should read compensated cirrhotic patients may be asymptomatic for years or decades: 
page 4 
We evaluated if the LDSI is sensitive to these differences should read We evaluated if the LDSI was 
sensitive to these differences. 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) 
 Accept after minor compulsory revisions Advice on publication: 
 A paper of considerable merit and interest in its field Level of interest: 
 Needs some language corrections before being published Quality of written English: 
Declaration of competing interests: 
none 
Reviewer's report 
 Generic and Disease-Specific Health Related Quality of Life in Non-cirrhotic, Cirrhotic and Title: 
Transplanted Liver Patients: a cross-sectional study. 
 2  6 September 2003 Version: Date: 
 john C bucuvalas Reviewer: 
Reviewer's report: 
General 
The report is comprehensive and examines a large population of patients with a wide range of liver disease. The information presented is of interest to hepatologists, policy makers, patients and families. 
Discretionary Revisions (which the author can choose to ignore) 
1. The definition used to identify NC and CC are not based on established criteria. Might a simple classification scheme like the Childs-pugh measure be applied 
2. The symptoms addressed in the final figure do not include any of the potential side effects of 
immunosuppressive medication. In future studies, it might be worthwhile to address specifically the effects of these medications on quality of life 
Minor Compulsory Revisions (such as missing labels on figures, or the wrong use of a term, which 
the author can be trusted to correct) 1. The color of the bars for liver transplant recipients in figures 1 and 4 are inconsistent 2. Throughout the report, there are errors in grammar. Close proofreading is 
recommended.(examples) 
3. Were the clinical conditions of those who did not respond different from the respondents, a potential area of bias. 
page 14 
compensated cirrhotic patients may be a symptomatic for years or decades: should read compensated cirrhotic patients may be asymptomatic for years or decades: 
page 4 
We evaluated if the LDSI is sensitive to these differences should read We evaluated if the LDSI was 
sensitive to these differences. 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) 
 Accept after minor compulsory revisions Advice on publication: 
 A paper of considerable merit and interest in its field Level of interest: 
 Needs some language corrections before being published Quality of written English: 
Declaration of competing interests: 
none 
Please review this paper.
user
Reviewer's report 
 Generic and Disease-Specific Health Related Quality of Life in Non-cirrhotic, Cirrhotic and Title: 
Transplanted Liver Patients: a cross-sectional study. 
 2  6 September 2003 Version: Date: 
 john C bucuvalas Reviewer: 
Reviewer's report: 
General 
The report is comprehensive and examines a large population of patients with a wide range of liver disease. The information presented is of interest to hepatologists, policy makers, patients and families. 
Discretionary Revisions (which the author can choose to ignore) 
1. The definition used to identify NC and CC are not based on established criteria. Might a simple classification scheme like the Childs-pugh measure be applied 
2. The symptoms addressed in the final figure do not include any of the potential side effects of 
immunosuppressive medication. In future studies, it might be worthwhile to address specifically the effects of these medications on quality of life 
Minor Compulsory Revisions (such as missing labels on figures, or the wrong use of a term, which 
the author can be trusted to correct) 1. The color of the bars for liver transplant recipients in figures 1 and 4 are inconsistent 2. Throughout the report, there are errors in grammar. Close proofreading is 
recommended.(examples) 
3. Were the clinical conditions of those who did not respond different from the respondents, a potential area of bias. 
page 14 
compensated cirrhotic patients may be a symptomatic for years or decades: should read compensated cirrhotic patients may be asymptomatic for years or decades: 
page 4 
We evaluated if the LDSI is sensitive to these differences should read We evaluated if the LDSI was 
sensitive to these differences. 
Major Compulsory Revisions (that the author must respond to before a decision on publication can 
be reached) 
 Accept after minor compulsory revisions Advice on publication: 
 A paper of considerable merit and interest in its field Level of interest: 
 Needs some language corrections before being published Quality of written English: 
Declaration of competing interests: 
none 
assistant