Reviewer's report
Title:The Optimal Screening Interval for Gastric Cancer using
Esophago-gastro-duodenoscopy in Japan
Version: 1Date:19 April 2012
Reviewer: Kenneth E.L. McColl
Reviewer's report:
More information is required concerning the exact protocol for the endoscopies.
Major Compulsory Revisions:
1. Did each patient have an annual endoscopy over the five year period? Were
any lost to follow-up? If so details of that are required. If a patient was found to
have gastric cancer were they then removed from further annual follow-up?
2. Further details are also required regarding the stage of each cancer
diagnosed.
3. Had any of the patients had an endoscopy before they were entered into this
endoscopy screening protocol?
4. Surely the stage and curability of the cancer detected is more important than
the actual incidence? This should be discussed.
5. The most important risk factor for the development of gastric cancer is atrophic
gastritis. Information is required concerning the presence and severity of
histological atrophy of both the antral and body mucosa and relationship between
that and the subsequent risk of gastric cancer.
6. When determining the frequency of screening for gastric cancer it is surely
important to take into account the influence of atrophic gastritis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:The Optimal Screening Interval for Gastric Cancer using
Esophago-gastro-duodenoscopy in Japan
Version: 1Date:19 April 2012
Reviewer: Kenneth E.L. McColl
Reviewer's report:
More information is required concerning the exact protocol for the endoscopies.
Major Compulsory Revisions:
1. Did each patient have an annual endoscopy over the five year period? Were
any lost to follow-up? If so details of that are required. If a patient was found to
have gastric cancer were they then removed from further annual follow-up?
2. Further details are also required regarding the stage of each cancer
diagnosed.
3. Had any of the patients had an endoscopy before they were entered into this
endoscopy screening protocol?
4. Surely the stage and curability of the cancer detected is more important than
the actual incidence? This should be discussed.
5. The most important risk factor for the development of gastric cancer is atrophic
gastritis. Information is required concerning the presence and severity of
histological atrophy of both the antral and body mucosa and relationship between
that and the subsequent risk of gastric cancer.
6. When determining the frequency of screening for gastric cancer it is surely
important to take into account the influence of atrophic gastritis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:The Optimal Screening Interval for Gastric Cancer using
Esophago-gastro-duodenoscopy in Japan
Version: 1Date:19 April 2012
Reviewer: Kenneth E.L. McColl
Reviewer's report:
More information is required concerning the exact protocol for the endoscopies.
Major Compulsory Revisions:
1. Did each patient have an annual endoscopy over the five year period? Were
any lost to follow-up? If so details of that are required. If a patient was found to
have gastric cancer were they then removed from further annual follow-up?
2. Further details are also required regarding the stage of each cancer
diagnosed.
3. Had any of the patients had an endoscopy before they were entered into this
endoscopy screening protocol?
4. Surely the stage and curability of the cancer detected is more important than
the actual incidence? This should be discussed.
5. The most important risk factor for the development of gastric cancer is atrophic
gastritis. Information is required concerning the presence and severity of
histological atrophy of both the antral and body mucosa and relationship between
that and the subsequent risk of gastric cancer.
6. When determining the frequency of screening for gastric cancer it is surely
important to take into account the influence of atrophic gastritis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant