Title: Growth development of children and adolescents with inflammatory bowel disease in the
period 2000-2014 based on data of the Saxon Pediatric IBD Registry: A population-based study
Version: 0 Date: 30 Sep 2023
Reviewer:  Matthew Carroll
Reviewer's report:
Thank you for the opportunity to review this manuscript which has analyzed growth trends at
diagnosis in a regional German cohort of pediatric patients with IBD. These data confirm our
existing understanding of the impact of IBD upon growth but do not provide new insights or
understanding.  The authors state that studying the growth patterns of children with IBD leads to
the creation and improvement of an effective and efficient care structure for IBD health services
but fail to explain how. What link does growth data have to improved care, in particular, cross
sectional growth data at diagnosis rather than longitudinal data that may reflect the superiority
of certain therapies over others?
There are several grammatical issues that need to be addressed.
line 39-40: "...was for children both sex negative" - this does not make sense. Please revise. I
believe  you mean that there were no observed differences between genders?
Line 43-44: same as above
Line 42: please indicate which version of the child growth curve was used (KIGGS)
line 61: please explain what 'S3' is
line 68-70:  this should indicate that these changes are with respect to the Saxony cohort as per
the reference listed
line 77-82: very long sentence with awkward syntax. Suggest revising
Line 113-115: confusing structure. The 421 patients with anthropometric data consisted of 250
males and 171 females. Sentence needs to be reworded.
line 26: delete "There were"
line 147 and figure 2: MC and CU need to be defined - only exist as abbreviations on x-axis.
Same for figure 4. Furthermore, they are not included in the subsequent table of abbreviations.
line 210: suggest substituting "apparent" or "present" for "obviously"
line 221: remove comma after "that"
line 222: remove the 'with' preceding 'underweight'.
line 223: remove comma after 'with'; insert 'an' before 'increased', change 'at' to 'by'
line 223: change 'has' to 'have'
line 231: remove comma after 'proposed'; parental should not be capitalized
line 235-237: How has the creation of your database led to the creation and improvement of an
effective and efficient care structure for IBD health services. What have you done, what have
you changed about your care and delivery structure/methods?
line 248: delete 'but it could not be larger'
Title: Growth development of children and adolescents with inflammatory bowel disease in the
period 2000-2014 based on data of the Saxon Pediatric IBD Registry: A population-based study
Version: 0 Date: 30 Sep 2023
Reviewer:  Matthew Carroll
Reviewer's report:
Thank you for the opportunity to review this manuscript which has analyzed growth trends at
diagnosis in a regional German cohort of pediatric patients with IBD. These data confirm our
existing understanding of the impact of IBD upon growth but do not provide new insights or
understanding.  The authors state that studying the growth patterns of children with IBD leads to
the creation and improvement of an effective and efficient care structure for IBD health services
but fail to explain how. What link does growth data have to improved care, in particular, cross
sectional growth data at diagnosis rather than longitudinal data that may reflect the superiority
of certain therapies over others?
There are several grammatical issues that need to be addressed.
line 39-40: "...was for children both sex negative" - this does not make sense. Please revise. I
believe  you mean that there were no observed differences between genders?
Line 43-44: same as above
Line 42: please indicate which version of the child growth curve was used (KIGGS)
line 61: please explain what 'S3' is
line 68-70:  this should indicate that these changes are with respect to the Saxony cohort as per
the reference listed
line 77-82: very long sentence with awkward syntax. Suggest revising
Line 113-115: confusing structure. The 421 patients with anthropometric data consisted of 250
males and 171 females. Sentence needs to be reworded.
line 26: delete "There were"
line 147 and figure 2: MC and CU need to be defined - only exist as abbreviations on x-axis.
Same for figure 4. Furthermore, they are not included in the subsequent table of abbreviations.
line 210: suggest substituting "apparent" or "present" for "obviously"
line 221: remove comma after "that"
line 222: remove the 'with' preceding 'underweight'.
line 223: remove comma after 'with'; insert 'an' before 'increased', change 'at' to 'by'
line 223: change 'has' to 'have'
line 231: remove comma after 'proposed'; parental should not be capitalized
line 235-237: How has the creation of your database led to the creation and improvement of an
effective and efficient care structure for IBD health services. What have you done, what have
you changed about your care and delivery structure/methods?
line 248: delete 'but it could not be larger'
Please review this paper.
user
Title: Growth development of children and adolescents with inflammatory bowel disease in the
period 2000-2014 based on data of the Saxon Pediatric IBD Registry: A population-based study
Version: 0 Date: 30 Sep 2023
Reviewer:  Matthew Carroll
Reviewer's report:
Thank you for the opportunity to review this manuscript which has analyzed growth trends at
diagnosis in a regional German cohort of pediatric patients with IBD. These data confirm our
existing understanding of the impact of IBD upon growth but do not provide new insights or
understanding.  The authors state that studying the growth patterns of children with IBD leads to
the creation and improvement of an effective and efficient care structure for IBD health services
but fail to explain how. What link does growth data have to improved care, in particular, cross
sectional growth data at diagnosis rather than longitudinal data that may reflect the superiority
of certain therapies over others?
There are several grammatical issues that need to be addressed.
line 39-40: "...was for children both sex negative" - this does not make sense. Please revise. I
believe  you mean that there were no observed differences between genders?
Line 43-44: same as above
Line 42: please indicate which version of the child growth curve was used (KIGGS)
line 61: please explain what 'S3' is
line 68-70:  this should indicate that these changes are with respect to the Saxony cohort as per
the reference listed
line 77-82: very long sentence with awkward syntax. Suggest revising
Line 113-115: confusing structure. The 421 patients with anthropometric data consisted of 250
males and 171 females. Sentence needs to be reworded.
line 26: delete "There were"
line 147 and figure 2: MC and CU need to be defined - only exist as abbreviations on x-axis.
Same for figure 4. Furthermore, they are not included in the subsequent table of abbreviations.
line 210: suggest substituting "apparent" or "present" for "obviously"
line 221: remove comma after "that"
line 222: remove the 'with' preceding 'underweight'.
line 223: remove comma after 'with'; insert 'an' before 'increased', change 'at' to 'by'
line 223: change 'has' to 'have'
line 231: remove comma after 'proposed'; parental should not be capitalized
line 235-237: How has the creation of your database led to the creation and improvement of an
effective and efficient care structure for IBD health services. What have you done, what have
you changed about your care and delivery structure/methods?
line 248: delete 'but it could not be larger'
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