Reviewer's report
Title:Age-of-onset-dependent Influence of NOD2/CARD15 gene variants on
Disease behaviour and treatment in Crohn's disease
Version: 2Date:22 January 2013
Reviewer: Maria Francisca Gonzalez-Escribano
Reviewer's report:
I have reviewed the revised version of the manuscript entitled “Age of onset
dependent influence of NOD2/CARD15 gene variants on disease behaviour and
treatment in Crohn´s disease” by Posovszky et al. I have also read the response
of the authors to reviewers.
The authors have made a big effort to meet the different questiones raised and to
improve the original manuscript. Unfortunately, in my opinion, the main problems
persist. Thus, the most original point of the manuscript (BMD variants /
osteoporosis and NOD2) is lost among other results and comparisons.
Other questions:
1. Taking into account the sample size, it is difficult to extract conclusions with
the type of analysis performed and the number of variables included. Likely some
of the variables are not independent why authors did not performed amultivariate
analysis?
2. In the section “Pediatric-onset CD patients….” of the Results (page 10) the
numbers of the Figures seem to be erroneous
3. Authors suggest a trend of patients with variants of NOD2 towards low BMD
but the frequency of patients with two variants is the same among patients with
low BMD as among patients with normal BMD
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Age-of-onset-dependent Influence of NOD2/CARD15 gene variants on
Disease behaviour and treatment in Crohn's disease
Version: 2Date:22 January 2013
Reviewer: Maria Francisca Gonzalez-Escribano
Reviewer's report:
I have reviewed the revised version of the manuscript entitled “Age of onset
dependent influence of NOD2/CARD15 gene variants on disease behaviour and
treatment in Crohn´s disease” by Posovszky et al. I have also read the response
of the authors to reviewers.
The authors have made a big effort to meet the different questiones raised and to
improve the original manuscript. Unfortunately, in my opinion, the main problems
persist. Thus, the most original point of the manuscript (BMD variants /
osteoporosis and NOD2) is lost among other results and comparisons.
Other questions:
1. Taking into account the sample size, it is difficult to extract conclusions with
the type of analysis performed and the number of variables included. Likely some
of the variables are not independent why authors did not performed amultivariate
analysis?
2. In the section “Pediatric-onset CD patients….” of the Results (page 10) the
numbers of the Figures seem to be erroneous
3. Authors suggest a trend of patients with variants of NOD2 towards low BMD
but the frequency of patients with two variants is the same among patients with
low BMD as among patients with normal BMD
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Age-of-onset-dependent Influence of NOD2/CARD15 gene variants on
Disease behaviour and treatment in Crohn's disease
Version: 2Date:22 January 2013
Reviewer: Maria Francisca Gonzalez-Escribano
Reviewer's report:
I have reviewed the revised version of the manuscript entitled “Age of onset
dependent influence of NOD2/CARD15 gene variants on disease behaviour and
treatment in Crohn´s disease” by Posovszky et al. I have also read the response
of the authors to reviewers.
The authors have made a big effort to meet the different questiones raised and to
improve the original manuscript. Unfortunately, in my opinion, the main problems
persist. Thus, the most original point of the manuscript (BMD variants /
osteoporosis and NOD2) is lost among other results and comparisons.
Other questions:
1. Taking into account the sample size, it is difficult to extract conclusions with
the type of analysis performed and the number of variables included. Likely some
of the variables are not independent why authors did not performed amultivariate
analysis?
2. In the section “Pediatric-onset CD patients….” of the Results (page 10) the
numbers of the Figures seem to be erroneous
3. Authors suggest a trend of patients with variants of NOD2 towards low BMD
but the frequency of patients with two variants is the same among patients with
low BMD as among patients with normal BMD
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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