Reviewer's report
Title:Erythromycin versus neomycin in the treatment of hepatic encephalopathy
in cirrhosis: a randomized double-blind study
Version: 2Date:14 June 2012
Reviewer: Mariano Malaguarnera
Reviewer's report:
Hepatic encephalopathy is one of the major complications in cirrhosis and in the
past, few treatments are used for severe encephalopathy such as rifaximina,
lactulose, flumazenil, L acetyl carnitine, probiotics.
MINOR REVISION
The methods should be better described.
The use of erytromycin versus neomycin seems to reduce the hospitalisation
length, however is necessary a better valuation of hepatic encephalopathy
(grading).
Were there patients in coma? If there were patients in coma, how did patients
take the treatment?
Did the study have a follow up period?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Erythromycin versus neomycin in the treatment of hepatic encephalopathy
in cirrhosis: a randomized double-blind study
Version: 2Date:14 June 2012
Reviewer: Mariano Malaguarnera
Reviewer's report:
Hepatic encephalopathy is one of the major complications in cirrhosis and in the
past, few treatments are used for severe encephalopathy such as rifaximina,
lactulose, flumazenil, L acetyl carnitine, probiotics.
MINOR REVISION
The methods should be better described.
The use of erytromycin versus neomycin seems to reduce the hospitalisation
length, however is necessary a better valuation of hepatic encephalopathy
(grading).
Were there patients in coma? If there were patients in coma, how did patients
take the treatment?
Did the study have a follow up period?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Erythromycin versus neomycin in the treatment of hepatic encephalopathy
in cirrhosis: a randomized double-blind study
Version: 2Date:14 June 2012
Reviewer: Mariano Malaguarnera
Reviewer's report:
Hepatic encephalopathy is one of the major complications in cirrhosis and in the
past, few treatments are used for severe encephalopathy such as rifaximina,
lactulose, flumazenil, L acetyl carnitine, probiotics.
MINOR REVISION
The methods should be better described.
The use of erytromycin versus neomycin seems to reduce the hospitalisation
length, however is necessary a better valuation of hepatic encephalopathy
(grading).
Were there patients in coma? If there were patients in coma, how did patients
take the treatment?
Did the study have a follow up period?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant