Reviewer's report
Title:Co-occurrence of IBS and symptoms of anxiety or depression, among
Norwegian twins, is influenced by both heredity and intrauterine growth
Version:2Date:29 October 2014
Reviewer: Ji Won Kim
Reviewer's report:
Comment to the Editor/Authors
2014-09-20
General
The current study “Co-occurrence of IBS and symptoms of anxiety or depression,
among Norwegian twins, is influenced by both heredity and intrauterine growth”
touched the possible pathogenesis of IBS in patients who had co-morbidity IBS
and anxiety/depression.
This study is interesting because what has rarely been studied IBS and mental
health outcome in twin patients. However, there are several points that are
further clearly delineated.
I have comments as follows:
Abstract
1. In the line 13-14,, “with anxiety (181.0 g, p<0.0001) and depression (249.9 g,
p<0.0001)’ # In this phrase, the mean of 181.0g and 249.9 g is not clear, this is
better to add (average birth weight difference 181.0 g, p<0.0001).
Introduction
1. In the line 53-55, authors described that “family factors comprise genetic factor
and/or early familial influence associated with being raised as twins in the same
household”. In my opinion, genetic factor is different from early familial influence,
and so it may need to clarify that how the authors differentiated genetic factor
and early familial influence.
Materials and Methods
1. Anxiety and depression is well known that they are very associates with
socio-economic condition of the patients, such as marital status, education and
other co-morbid disease. Are there any differences in the marital status (married
or not married or divorced) or education status (high school or university or
graduate) or co-morbid disease (diabetes, hypertension et al) in the Case and
Control?
Results
1. In the line 204-208, the meaning is confusing, and it may clearly describe that
cases of IBS with anxiety were more likely to have comorbid long-lasting muscle
pain, but cases of IBS with depression did not reach significance.
Discussion
1. In this study, there were no data about the current environmental state that
influence the IBS, anxiety, and depression, such as marital, educational,
occupational, and medical state. These are one of limitations of this study.
Reviewer's report
Title:Co-occurrence of IBS and symptoms of anxiety or depression, among
Norwegian twins, is influenced by both heredity and intrauterine growth
Version:2Date:29 October 2014
Reviewer: Ji Won Kim
Reviewer's report:
Comment to the Editor/Authors
2014-09-20
General
The current study “Co-occurrence of IBS and symptoms of anxiety or depression,
among Norwegian twins, is influenced by both heredity and intrauterine growth”
touched the possible pathogenesis of IBS in patients who had co-morbidity IBS
and anxiety/depression.
This study is interesting because what has rarely been studied IBS and mental
health outcome in twin patients. However, there are several points that are
further clearly delineated.
I have comments as follows:
Abstract
1. In the line 13-14,, “with anxiety (181.0 g, p<0.0001) and depression (249.9 g,
p<0.0001)’ # In this phrase, the mean of 181.0g and 249.9 g is not clear, this is
better to add (average birth weight difference 181.0 g, p<0.0001).
Introduction
1. In the line 53-55, authors described that “family factors comprise genetic factor
and/or early familial influence associated with being raised as twins in the same
household”. In my opinion, genetic factor is different from early familial influence,
and so it may need to clarify that how the authors differentiated genetic factor
and early familial influence.
Materials and Methods
1. Anxiety and depression is well known that they are very associates with
socio-economic condition of the patients, such as marital status, education and
other co-morbid disease. Are there any differences in the marital status (married
or not married or divorced) or education status (high school or university or
graduate) or co-morbid disease (diabetes, hypertension et al) in the Case and
Control?
Results
1. In the line 204-208, the meaning is confusing, and it may clearly describe that
cases of IBS with anxiety were more likely to have comorbid long-lasting muscle
pain, but cases of IBS with depression did not reach significance.
Discussion
1. In this study, there were no data about the current environmental state that
influence the IBS, anxiety, and depression, such as marital, educational,
occupational, and medical state. These are one of limitations of this study.
Please review this paper.
user
Reviewer's report
Title:Co-occurrence of IBS and symptoms of anxiety or depression, among
Norwegian twins, is influenced by both heredity and intrauterine growth
Version:2Date:29 October 2014
Reviewer: Ji Won Kim
Reviewer's report:
Comment to the Editor/Authors
2014-09-20
General
The current study “Co-occurrence of IBS and symptoms of anxiety or depression,
among Norwegian twins, is influenced by both heredity and intrauterine growth”
touched the possible pathogenesis of IBS in patients who had co-morbidity IBS
and anxiety/depression.
This study is interesting because what has rarely been studied IBS and mental
health outcome in twin patients. However, there are several points that are
further clearly delineated.
I have comments as follows:
Abstract
1. In the line 13-14,, “with anxiety (181.0 g, p<0.0001) and depression (249.9 g,
p<0.0001)’ # In this phrase, the mean of 181.0g and 249.9 g is not clear, this is
better to add (average birth weight difference 181.0 g, p<0.0001).
Introduction
1. In the line 53-55, authors described that “family factors comprise genetic factor
and/or early familial influence associated with being raised as twins in the same
household”. In my opinion, genetic factor is different from early familial influence,
and so it may need to clarify that how the authors differentiated genetic factor
and early familial influence.
Materials and Methods
1. Anxiety and depression is well known that they are very associates with
socio-economic condition of the patients, such as marital status, education and
other co-morbid disease. Are there any differences in the marital status (married
or not married or divorced) or education status (high school or university or
graduate) or co-morbid disease (diabetes, hypertension et al) in the Case and
Control?
Results
1. In the line 204-208, the meaning is confusing, and it may clearly describe that
cases of IBS with anxiety were more likely to have comorbid long-lasting muscle
pain, but cases of IBS with depression did not reach significance.
Discussion
1. In this study, there were no data about the current environmental state that
influence the IBS, anxiety, and depression, such as marital, educational,
occupational, and medical state. These are one of limitations of this study.
assistant