Title: Expression profile and N6-methyadenosine modification of Circular RNA analysis in
MAFLD
Version: 1 Date: 02 Jan 2025
Reviewer's report:
After reviewing the revised manuscript and the point-by-point response, it is evident that
the authors have addressed most of the critical concerns raised in the first review. They
provided detailed explanations, improved the clarity of figures, and expanded the methodology,
particularly for microarray analysis and SRAMP predictions. While the study remains
exploratory, lacking experimental validation of causal relationships between m6A modifications
and circRNA functions, the authors acknowledged these limitations and suggested future
research directions. The manuscript’s language and structure have improved, although minor
grammatical issues and phrasing could benefit from further polishing. Overall, the study
provides valuable insights into the regulatory role of m6A modified circRNAs in MAFLD and
is well aligned with the scope of BMC gastroenterology. I recommend accepting this article.
Title: Expression profile and N6-methyadenosine modification of Circular RNA analysis in
MAFLD
Version: 1 Date: 02 Jan 2025
Reviewer's report:
After reviewing the revised manuscript and the point-by-point response, it is evident that
the authors have addressed most of the critical concerns raised in the first review. They
provided detailed explanations, improved the clarity of figures, and expanded the methodology,
particularly for microarray analysis and SRAMP predictions. While the study remains
exploratory, lacking experimental validation of causal relationships between m6A modifications
and circRNA functions, the authors acknowledged these limitations and suggested future
research directions. The manuscript’s language and structure have improved, although minor
grammatical issues and phrasing could benefit from further polishing. Overall, the study
provides valuable insights into the regulatory role of m6A modified circRNAs in MAFLD and
is well aligned with the scope of BMC gastroenterology. I recommend accepting this article.
Please review this paper.
user
Title: Expression profile and N6-methyadenosine modification of Circular RNA analysis in
MAFLD
Version: 1 Date: 02 Jan 2025
Reviewer's report:
After reviewing the revised manuscript and the point-by-point response, it is evident that
the authors have addressed most of the critical concerns raised in the first review. They
provided detailed explanations, improved the clarity of figures, and expanded the methodology,
particularly for microarray analysis and SRAMP predictions. While the study remains
exploratory, lacking experimental validation of causal relationships between m6A modifications
and circRNA functions, the authors acknowledged these limitations and suggested future
research directions. The manuscript’s language and structure have improved, although minor
grammatical issues and phrasing could benefit from further polishing. Overall, the study
provides valuable insights into the regulatory role of m6A modified circRNAs in MAFLD and
is well aligned with the scope of BMC gastroenterology. I recommend accepting this article.
assistant