Title: Age- and sex-stratified detection rates and associated factors of colorectal neoplasia in
the Tianjin colorectal cancer screening program from 2012 to 2020
Version: 0 Date: 08 Oct 2023
Reviewer:  Pallop Siewchaisakul
Reviewer's report:
Introduction
1. I recommended author to provide more detail about the CRC screening and the burden of CRC
(term of incidence &mortality in Tianjin (briefly). So that reader would know how important
the CRC screening in Tianjin.
2. Line 68, page 4: I suggest author to give example or specify the risk factors. Author can also
state that this article would fulfil the knowledge gap by take those risk factors into account.
3. Line 140-141, Page 7: Could author describe how to recruit variables in the initial model and
how author  get the final model (did author perform, i.e., enter, backward or forward methods)?
Result
4. Regarding the analysis in Table 4, I recommended author to analyze stratified by sex and age,
and these may put in supplementary table.
5. I suggest to use the word multivariable, for the multivariate, readers might confuse with
multiple outcome.
6.  In the footnote, author wrote aOR, so that could author please use the abbreviation
consistently?
Discussion
7. One of the observed result show that the detection rate was higher in HRFQ than the FIT test.
I think this would be one of the discussion topic in this manuscript?
Title: Age- and sex-stratified detection rates and associated factors of colorectal neoplasia in
the Tianjin colorectal cancer screening program from 2012 to 2020
Version: 0 Date: 08 Oct 2023
Reviewer:  Pallop Siewchaisakul
Reviewer's report:
Introduction
1. I recommended author to provide more detail about the CRC screening and the burden of CRC
(term of incidence &mortality in Tianjin (briefly). So that reader would know how important
the CRC screening in Tianjin.
2. Line 68, page 4: I suggest author to give example or specify the risk factors. Author can also
state that this article would fulfil the knowledge gap by take those risk factors into account.
3. Line 140-141, Page 7: Could author describe how to recruit variables in the initial model and
how author  get the final model (did author perform, i.e., enter, backward or forward methods)?
Result
4. Regarding the analysis in Table 4, I recommended author to analyze stratified by sex and age,
and these may put in supplementary table.
5. I suggest to use the word multivariable, for the multivariate, readers might confuse with
multiple outcome.
6.  In the footnote, author wrote aOR, so that could author please use the abbreviation
consistently?
Discussion
7. One of the observed result show that the detection rate was higher in HRFQ than the FIT test.
I think this would be one of the discussion topic in this manuscript?
Please review this paper.
user
Title: Age- and sex-stratified detection rates and associated factors of colorectal neoplasia in
the Tianjin colorectal cancer screening program from 2012 to 2020
Version: 0 Date: 08 Oct 2023
Reviewer:  Pallop Siewchaisakul
Reviewer's report:
Introduction
1. I recommended author to provide more detail about the CRC screening and the burden of CRC
(term of incidence &mortality in Tianjin (briefly). So that reader would know how important
the CRC screening in Tianjin.
2. Line 68, page 4: I suggest author to give example or specify the risk factors. Author can also
state that this article would fulfil the knowledge gap by take those risk factors into account.
3. Line 140-141, Page 7: Could author describe how to recruit variables in the initial model and
how author  get the final model (did author perform, i.e., enter, backward or forward methods)?
Result
4. Regarding the analysis in Table 4, I recommended author to analyze stratified by sex and age,
and these may put in supplementary table.
5. I suggest to use the word multivariable, for the multivariate, readers might confuse with
multiple outcome.
6.  In the footnote, author wrote aOR, so that could author please use the abbreviation
consistently?
Discussion
7. One of the observed result show that the detection rate was higher in HRFQ than the FIT test.
I think this would be one of the discussion topic in this manuscript?
assistant