Reviewer ’s report  
 
Title: Amoxicillin/Clavulanic Acid -Induced Pancreatitis: Case Report  
 
Version: 1 Date: 01 May 2018  
 
Reviewer: Armand Abergel  
 
Reviewer's report:  
 
I think that the authors have responded to the comments of the first revie wer 
 
1) I would like to add 2 references I have found  
Cerezo Ruiz A,  Domínguez Jiménez JL,  Aníbal Cortez Quiroga G,  García Quintana JM  
Acute pancreatitis associated with amoxycillin -clavulanic acid  
Gastroenterología y Hepatología 2015;38:410 -1. 
http:// dx.doi.org/10.1016/j.gastrohep.2014.08.004   
(free access)  
 
Campo L, All Halak A, Olivo R et al.  
80th Annual Scientific Meeting of the American College of Gastroenterology  
Am J Gastroenterol 2015;110: Issue S1, Octobre 2015, page S89, abstract 202  
I have loa ded the abstract  
A table synthesizing the main characteristics (age, sex, EUS, delay between introduction of the 
drug and pancreatitis, reintroduction.......)  on pancreatitis and Amoxicillin/Clavulanic Acid, 
Amoxicillin, Ampicillin, Penicillin could be v ery useful for the readers (Sammett et al. 1998; 
Hanlien 1987; Campo et al. 2015 ; Cerezo Ruiz et al. 2015 ; Galindo et al; 1995 + the case report 
of the authors  
 
2) The authors can add the main mechanisms that can cause DIPI : see Jones et al. 2015 page 47  
 
3) Can the authors comment on the aspect of the gallbladder on MRI, it looks like there is a 
pseudodiverticula (don't add the response in the text please)  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary co ntrols?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to asses s any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this man uscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past f ive years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees,  funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I h ave no competing interests' below  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Amoxicillin/Clavulanic Acid -Induced Pancreatitis: Case Report  
 
Version: 1 Date: 01 May 2018  
 
Reviewer: Armand Abergel  
 
Reviewer's report:  
 
I think that the authors have responded to the comments of the first revie wer 
 
1) I would like to add 2 references I have found  
Cerezo Ruiz A,  Domínguez Jiménez JL,  Aníbal Cortez Quiroga G,  García Quintana JM  
Acute pancreatitis associated with amoxycillin -clavulanic acid  
Gastroenterología y Hepatología 2015;38:410 -1. 
http:// dx.doi.org/10.1016/j.gastrohep.2014.08.004   
(free access)  
 
Campo L, All Halak A, Olivo R et al.  
80th Annual Scientific Meeting of the American College of Gastroenterology  
Am J Gastroenterol 2015;110: Issue S1, Octobre 2015, page S89, abstract 202  
I have loa ded the abstract  
A table synthesizing the main characteristics (age, sex, EUS, delay between introduction of the 
drug and pancreatitis, reintroduction.......)  on pancreatitis and Amoxicillin/Clavulanic Acid, 
Amoxicillin, Ampicillin, Penicillin could be v ery useful for the readers (Sammett et al. 1998; 
Hanlien 1987; Campo et al. 2015 ; Cerezo Ruiz et al. 2015 ; Galindo et al; 1995 + the case report 
of the authors  
 
2) The authors can add the main mechanisms that can cause DIPI : see Jones et al. 2015 page 47  
 
3) Can the authors comment on the aspect of the gallbladder on MRI, it looks like there is a 
pseudodiverticula (don't add the response in the text please)  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary co ntrols?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to asses s any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this man uscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past f ive years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees,  funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I h ave no competing interests' below  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Amoxicillin/Clavulanic Acid -Induced Pancreatitis: Case Report  
 
Version: 1 Date: 01 May 2018  
 
Reviewer: Armand Abergel  
 
Reviewer's report:  
 
I think that the authors have responded to the comments of the first revie wer 
 
1) I would like to add 2 references I have found  
Cerezo Ruiz A,  Domínguez Jiménez JL,  Aníbal Cortez Quiroga G,  García Quintana JM  
Acute pancreatitis associated with amoxycillin -clavulanic acid  
Gastroenterología y Hepatología 2015;38:410 -1. 
http:// dx.doi.org/10.1016/j.gastrohep.2014.08.004   
(free access)  
 
Campo L, All Halak A, Olivo R et al.  
80th Annual Scientific Meeting of the American College of Gastroenterology  
Am J Gastroenterol 2015;110: Issue S1, Octobre 2015, page S89, abstract 202  
I have loa ded the abstract  
A table synthesizing the main characteristics (age, sex, EUS, delay between introduction of the 
drug and pancreatitis, reintroduction.......)  on pancreatitis and Amoxicillin/Clavulanic Acid, 
Amoxicillin, Ampicillin, Penicillin could be v ery useful for the readers (Sammett et al. 1998; 
Hanlien 1987; Campo et al. 2015 ; Cerezo Ruiz et al. 2015 ; Galindo et al; 1995 + the case report 
of the authors  
 
2) The authors can add the main mechanisms that can cause DIPI : see Jones et al. 2015 page 47  
 
3) Can the authors comment on the aspect of the gallbladder on MRI, it looks like there is a 
pseudodiverticula (don't add the response in the text please)  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary co ntrols?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to asses s any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this man uscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past f ive years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees,  funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I h ave no competing interests' below  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses.  I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do  not wish to be included in my named report can be included as confidential comments 
to the  editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant