Title: The Impact of Relaxing the Requirements for Dyspeptic Symptom Onset Frequency or
Duration in Rome IV Criteria on the Symptom Pattern and Diagnosis of Functional Dyspepsia
Version: 3 Date: 14 Sep 2024
Reviewer's report:
The study “The Impact of relaxing the requirements for dyspeptic symptom onset frequency or
duration in Rome IV Criteria on the symptom Pattern and Diagnosis of functional dyspepsia”
aims to describe the symptom characteristics of Rome IV criteria defined FD in China and
explore the impact of relaxing the requirements for symptoms onset frequency, severity and
duration of the Rome IV criteria on diagnosing FD.
Authors have analysed a topic very interesting and actual, especially in clinical practice.
The Rome Foundation itself has already proposed a modification of the Rome IV diagnostic
criteria for clinical practice, stating that a diagnosis of DGBI can still be done even if diagnostic
criteria of frequency and duration are not satisfied, providing that nature and bothersomeness of
symptoms (e.g. interfering with daily activities or quality of life) are present. (Rome Foundation
Clinical Diagnostic Criteria for Disorders of Gut-Brain Interaction. Drossman, Douglas A.Tack,
Jan et al. Gastroenterology, Volume 162, Issue 3, 675 – 679)
The study design (retrospective cross-sectional) is, however, a methodological limitation of
this study, since the diagnosis of FD is mostly based on clinical judgement, presence of recall
bias does not allow to consider data consistent. Moreover, authors used a self-administered
questionnaire survey (not standardized) to assess GI symptoms and characteristics. Furthermore,
not all participants might exactly know the meaning of dyspepsia, thus over- or underestimating
the real burden of symptoms.
Introduction, line 15, authors report “characterized by meal-related symptoms such as meal
unrelated symptoms such as epigastric…” not clear, please correct
Discussion, line 8 “then” instead of “than”, please correct
Title: The Impact of Relaxing the Requirements for Dyspeptic Symptom Onset Frequency or
Duration in Rome IV Criteria on the Symptom Pattern and Diagnosis of Functional Dyspepsia
Version: 3 Date: 14 Sep 2024
Reviewer's report:
The study “The Impact of relaxing the requirements for dyspeptic symptom onset frequency or
duration in Rome IV Criteria on the symptom Pattern and Diagnosis of functional dyspepsia”
aims to describe the symptom characteristics of Rome IV criteria defined FD in China and
explore the impact of relaxing the requirements for symptoms onset frequency, severity and
duration of the Rome IV criteria on diagnosing FD.
Authors have analysed a topic very interesting and actual, especially in clinical practice.
The Rome Foundation itself has already proposed a modification of the Rome IV diagnostic
criteria for clinical practice, stating that a diagnosis of DGBI can still be done even if diagnostic
criteria of frequency and duration are not satisfied, providing that nature and bothersomeness of
symptoms (e.g. interfering with daily activities or quality of life) are present. (Rome Foundation
Clinical Diagnostic Criteria for Disorders of Gut-Brain Interaction. Drossman, Douglas A.Tack,
Jan et al. Gastroenterology, Volume 162, Issue 3, 675 – 679)
The study design (retrospective cross-sectional) is, however, a methodological limitation of
this study, since the diagnosis of FD is mostly based on clinical judgement, presence of recall
bias does not allow to consider data consistent. Moreover, authors used a self-administered
questionnaire survey (not standardized) to assess GI symptoms and characteristics. Furthermore,
not all participants might exactly know the meaning of dyspepsia, thus over- or underestimating
the real burden of symptoms.
Introduction, line 15, authors report “characterized by meal-related symptoms such as meal
unrelated symptoms such as epigastric…” not clear, please correct
Discussion, line 8 “then” instead of “than”, please correct
Please review this paper.
user
Title: The Impact of Relaxing the Requirements for Dyspeptic Symptom Onset Frequency or
Duration in Rome IV Criteria on the Symptom Pattern and Diagnosis of Functional Dyspepsia
Version: 3 Date: 14 Sep 2024
Reviewer's report:
The study “The Impact of relaxing the requirements for dyspeptic symptom onset frequency or
duration in Rome IV Criteria on the symptom Pattern and Diagnosis of functional dyspepsia”
aims to describe the symptom characteristics of Rome IV criteria defined FD in China and
explore the impact of relaxing the requirements for symptoms onset frequency, severity and
duration of the Rome IV criteria on diagnosing FD.
Authors have analysed a topic very interesting and actual, especially in clinical practice.
The Rome Foundation itself has already proposed a modification of the Rome IV diagnostic
criteria for clinical practice, stating that a diagnosis of DGBI can still be done even if diagnostic
criteria of frequency and duration are not satisfied, providing that nature and bothersomeness of
symptoms (e.g. interfering with daily activities or quality of life) are present. (Rome Foundation
Clinical Diagnostic Criteria for Disorders of Gut-Brain Interaction. Drossman, Douglas A.Tack,
Jan et al. Gastroenterology, Volume 162, Issue 3, 675 – 679)
The study design (retrospective cross-sectional) is, however, a methodological limitation of
this study, since the diagnosis of FD is mostly based on clinical judgement, presence of recall
bias does not allow to consider data consistent. Moreover, authors used a self-administered
questionnaire survey (not standardized) to assess GI symptoms and characteristics. Furthermore,
not all participants might exactly know the meaning of dyspepsia, thus over- or underestimating
the real burden of symptoms.
Introduction, line 15, authors report “characterized by meal-related symptoms such as meal
unrelated symptoms such as epigastric…” not clear, please correct
Discussion, line 8 “then” instead of “than”, please correct
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