Reviewer's report
Title:Schwann cell hamartoma: Case report
Version: 2Date:8 March 2011
Reviewer: Jason L Hornick
Reviewer's report:
The authors report a case of mucosal Schwann cell hamartoma of the colon and
briefly discuss the differential diagnosis. The findings are well-documented, the
discussion appropriately contextualizes the diagnosis, and the pathologic images
are good.
Minor essential revisions:
1. In the discussion (p. 5), the authors mention "benign fibroblastic polyps" (ref
15). Recent comprehensive immunohistochemical studies demonstrate that the
lesions previously reported as such are in fact identical to mucosal perineuriomas
(see Agaimy A, Stoehr R, Vieth M, Hartmann A. Benign serrated colorectal
fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal
polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF
mutations. Am J Surg Pathol. 2010 Nov;34(11):1663-71 and Groisman GM,
Polak-Charcon S. Fibroblastic polyp of the colon and colonic perineurioma: 2
names for a single entity? Am J Surg Pathol. 2008 Jul;32(7):1088-94). Moreover,
a distinctive feature of mucosal perineuriomas is the presence of an adjacent
serrated epithelial polyp (usually hyperplastic polyp, occasionally sessile serrated
polyp/adenoma) in around 70% of cases (this is not a feature of the other neural
polyps in the colorectum). Among colorectal polyps containing a spindle cell
proliferation, mucosal perineuriomas are much more common than mucosal
Schwann cell hamartomas. The manuscript would be improved by a brief
explanation of this change in classification/nomenclature and the histologic
differences between mucosal Schwann cell hamartoma and mucosal
perineurioma.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Schwann cell hamartoma: Case report
Version: 2Date:8 March 2011
Reviewer: Jason L Hornick
Reviewer's report:
The authors report a case of mucosal Schwann cell hamartoma of the colon and
briefly discuss the differential diagnosis. The findings are well-documented, the
discussion appropriately contextualizes the diagnosis, and the pathologic images
are good.
Minor essential revisions:
1. In the discussion (p. 5), the authors mention "benign fibroblastic polyps" (ref
15). Recent comprehensive immunohistochemical studies demonstrate that the
lesions previously reported as such are in fact identical to mucosal perineuriomas
(see Agaimy A, Stoehr R, Vieth M, Hartmann A. Benign serrated colorectal
fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal
polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF
mutations. Am J Surg Pathol. 2010 Nov;34(11):1663-71 and Groisman GM,
Polak-Charcon S. Fibroblastic polyp of the colon and colonic perineurioma: 2
names for a single entity? Am J Surg Pathol. 2008 Jul;32(7):1088-94). Moreover,
a distinctive feature of mucosal perineuriomas is the presence of an adjacent
serrated epithelial polyp (usually hyperplastic polyp, occasionally sessile serrated
polyp/adenoma) in around 70% of cases (this is not a feature of the other neural
polyps in the colorectum). Among colorectal polyps containing a spindle cell
proliferation, mucosal perineuriomas are much more common than mucosal
Schwann cell hamartomas. The manuscript would be improved by a brief
explanation of this change in classification/nomenclature and the histologic
differences between mucosal Schwann cell hamartoma and mucosal
perineurioma.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Schwann cell hamartoma: Case report
Version: 2Date:8 March 2011
Reviewer: Jason L Hornick
Reviewer's report:
The authors report a case of mucosal Schwann cell hamartoma of the colon and
briefly discuss the differential diagnosis. The findings are well-documented, the
discussion appropriately contextualizes the diagnosis, and the pathologic images
are good.
Minor essential revisions:
1. In the discussion (p. 5), the authors mention "benign fibroblastic polyps" (ref
15). Recent comprehensive immunohistochemical studies demonstrate that the
lesions previously reported as such are in fact identical to mucosal perineuriomas
(see Agaimy A, Stoehr R, Vieth M, Hartmann A. Benign serrated colorectal
fibroblastic polyps/intramucosal perineuriomas are true mixed epithelial-stromal
polyps (hybrid hyperplastic polyp/mucosal perineurioma) with frequent BRAF
mutations. Am J Surg Pathol. 2010 Nov;34(11):1663-71 and Groisman GM,
Polak-Charcon S. Fibroblastic polyp of the colon and colonic perineurioma: 2
names for a single entity? Am J Surg Pathol. 2008 Jul;32(7):1088-94). Moreover,
a distinctive feature of mucosal perineuriomas is the presence of an adjacent
serrated epithelial polyp (usually hyperplastic polyp, occasionally sessile serrated
polyp/adenoma) in around 70% of cases (this is not a feature of the other neural
polyps in the colorectum). Among colorectal polyps containing a spindle cell
proliferation, mucosal perineuriomas are much more common than mucosal
Schwann cell hamartomas. The manuscript would be improved by a brief
explanation of this change in classification/nomenclature and the histologic
differences between mucosal Schwann cell hamartoma and mucosal
perineurioma.
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant