Reviewer's report
Title:A Descriptive Study of Colorectal Function in Adults with Prader-Willi
Syndrome: High Prevalence of Constipation
Version:3Date:22 February 2014
Reviewer: antonino crinò
Reviewer's report:
This manuscript reports a descriptive study of colorectal function, including
constipation, in Prader-Willi syndrome. This argument has been sparsely
investigated in PWS. The paper is interesting and quite well written but some
comments are necessary.
Major Compulsory Revisions:
Data are not completely new and the population included in the study is limited.
In fact the study was performed only on 21 patients with PWS but information
about Rome III criteria are reported only for 17-20 subjects. The authors could
explain better the methodology of stool diary. About clinical examination the
authors report only the amount and consistency of feces in the rectum but not of
haemorrhoids, perianal sensibility, anal sphincter tone, rectal bleeding etc.
As the authors say, the study does not allow any conclusions. The discussion is
too simple and does not explain in depth the gastrointestinal problem found in
PWS. Can you explain better the reason for these bowel dysfunctions?
Minor Essential Revisons:
Abstract: in the results the percentage of feeling of obstructed defecation is 42%
(8/19), while <3 defecations per week is 47% (8/17). When you talk about GITT
delete "days" because it has been repeated twice.
Materials and methods: How many patients were obese?
Results - page 7 = in line 11 the word "hours" should be deleted.
There is any difference between sexes and colorectal dysfunctions in PWS?
Table 1 = please explain the term IBS - write that criteria are referred to Rome III
constipation criteria
Figure 2 = patients with GITT >3 days are 6, while in the text the pts reported
were 5.
Discretionary Revisions:
In the figure 1 and 2 I suggest reporting the median and the range of age of PWS
pts and the control group.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:A Descriptive Study of Colorectal Function in Adults with Prader-Willi
Syndrome: High Prevalence of Constipation
Version:3Date:22 February 2014
Reviewer: antonino crinò
Reviewer's report:
This manuscript reports a descriptive study of colorectal function, including
constipation, in Prader-Willi syndrome. This argument has been sparsely
investigated in PWS. The paper is interesting and quite well written but some
comments are necessary.
Major Compulsory Revisions:
Data are not completely new and the population included in the study is limited.
In fact the study was performed only on 21 patients with PWS but information
about Rome III criteria are reported only for 17-20 subjects. The authors could
explain better the methodology of stool diary. About clinical examination the
authors report only the amount and consistency of feces in the rectum but not of
haemorrhoids, perianal sensibility, anal sphincter tone, rectal bleeding etc.
As the authors say, the study does not allow any conclusions. The discussion is
too simple and does not explain in depth the gastrointestinal problem found in
PWS. Can you explain better the reason for these bowel dysfunctions?
Minor Essential Revisons:
Abstract: in the results the percentage of feeling of obstructed defecation is 42%
(8/19), while <3 defecations per week is 47% (8/17). When you talk about GITT
delete "days" because it has been repeated twice.
Materials and methods: How many patients were obese?
Results - page 7 = in line 11 the word "hours" should be deleted.
There is any difference between sexes and colorectal dysfunctions in PWS?
Table 1 = please explain the term IBS - write that criteria are referred to Rome III
constipation criteria
Figure 2 = patients with GITT >3 days are 6, while in the text the pts reported
were 5.
Discretionary Revisions:
In the figure 1 and 2 I suggest reporting the median and the range of age of PWS
pts and the control group.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:A Descriptive Study of Colorectal Function in Adults with Prader-Willi
Syndrome: High Prevalence of Constipation
Version:3Date:22 February 2014
Reviewer: antonino crinò
Reviewer's report:
This manuscript reports a descriptive study of colorectal function, including
constipation, in Prader-Willi syndrome. This argument has been sparsely
investigated in PWS. The paper is interesting and quite well written but some
comments are necessary.
Major Compulsory Revisions:
Data are not completely new and the population included in the study is limited.
In fact the study was performed only on 21 patients with PWS but information
about Rome III criteria are reported only for 17-20 subjects. The authors could
explain better the methodology of stool diary. About clinical examination the
authors report only the amount and consistency of feces in the rectum but not of
haemorrhoids, perianal sensibility, anal sphincter tone, rectal bleeding etc.
As the authors say, the study does not allow any conclusions. The discussion is
too simple and does not explain in depth the gastrointestinal problem found in
PWS. Can you explain better the reason for these bowel dysfunctions?
Minor Essential Revisons:
Abstract: in the results the percentage of feeling of obstructed defecation is 42%
(8/19), while <3 defecations per week is 47% (8/17). When you talk about GITT
delete "days" because it has been repeated twice.
Materials and methods: How many patients were obese?
Results - page 7 = in line 11 the word "hours" should be deleted.
There is any difference between sexes and colorectal dysfunctions in PWS?
Table 1 = please explain the term IBS - write that criteria are referred to Rome III
constipation criteria
Figure 2 = patients with GITT >3 days are 6, while in the text the pts reported
were 5.
Discretionary Revisions:
In the figure 1 and 2 I suggest reporting the median and the range of age of PWS
pts and the control group.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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