Title: Association between hematocrit and mortality in critically ill patients with acute
pancreatitis: a retrospective cohort study
Version: 1 Date: 17 Jan 2025
Reviewer's report:
This retrospective cohort study investigates the association between hematocrit (Ht) levels and
mortality in critically ill patients with acute pancreatitis (AP), using data from the MIMIC
database. The authors identify a U-shaped relationship between Ht and 28-day mortality,
highlighting both low and high levels of Ht as independent predictors of adverse outcomes.
Non-linear regression analyses further substantiate the findings, suggesting that Ht could be an
important parameter in prognostic evaluations.
This study adds little novelty to the existing literature, as the association between hematocrit
and outcomes in AP has been well-established since the publication of the Ranson criteria in
1974. The Ranson scoring system, a widely used prognostic tool for AP, incorporates Ht as an
indicator of hemoconcentration, a marker of disease severity. High hematocrit is linked to fluid
loss and hypovolemia, while low levels often result from aggressive fluid resuscitation. These
relationships have been extensively documented in the context of AP severity and mortality.
A notable omission is the lack of citation of the Ranson criteria, which for decades has
included hematocrit as part of its scoring methodology. Ranson's criteria serve as a foundational
framework for predicting outcomes in AP, encompassing parameters like age, glucose, and Ht
changes over 48 hours. Ignoring this critical context weakens the study’s claim of providing
new insights, as the primary associations have long been known and remain clinically relevant.
Given the absence of novel findings and the failure to adequately contextualize the study within
existing literature, I recommend against publication. The study’s conclusion that Ht correlates
with mortality in AP reiterates what has been known for nearly five decades without offering
new mechanistic insights, innovative methodologies, or significant clinical implications. This
lack of originality diminishes the paper's contribution to advancing the field.
Title: Association between hematocrit and mortality in critically ill patients with acute
pancreatitis: a retrospective cohort study
Version: 1 Date: 17 Jan 2025
Reviewer's report:
This retrospective cohort study investigates the association between hematocrit (Ht) levels and
mortality in critically ill patients with acute pancreatitis (AP), using data from the MIMIC
database. The authors identify a U-shaped relationship between Ht and 28-day mortality,
highlighting both low and high levels of Ht as independent predictors of adverse outcomes.
Non-linear regression analyses further substantiate the findings, suggesting that Ht could be an
important parameter in prognostic evaluations.
This study adds little novelty to the existing literature, as the association between hematocrit
and outcomes in AP has been well-established since the publication of the Ranson criteria in
1974. The Ranson scoring system, a widely used prognostic tool for AP, incorporates Ht as an
indicator of hemoconcentration, a marker of disease severity. High hematocrit is linked to fluid
loss and hypovolemia, while low levels often result from aggressive fluid resuscitation. These
relationships have been extensively documented in the context of AP severity and mortality.
A notable omission is the lack of citation of the Ranson criteria, which for decades has
included hematocrit as part of its scoring methodology. Ranson's criteria serve as a foundational
framework for predicting outcomes in AP, encompassing parameters like age, glucose, and Ht
changes over 48 hours. Ignoring this critical context weakens the study’s claim of providing
new insights, as the primary associations have long been known and remain clinically relevant.
Given the absence of novel findings and the failure to adequately contextualize the study within
existing literature, I recommend against publication. The study’s conclusion that Ht correlates
with mortality in AP reiterates what has been known for nearly five decades without offering
new mechanistic insights, innovative methodologies, or significant clinical implications. This
lack of originality diminishes the paper's contribution to advancing the field.
Please review this paper.
user
Title: Association between hematocrit and mortality in critically ill patients with acute
pancreatitis: a retrospective cohort study
Version: 1 Date: 17 Jan 2025
Reviewer's report:
This retrospective cohort study investigates the association between hematocrit (Ht) levels and
mortality in critically ill patients with acute pancreatitis (AP), using data from the MIMIC
database. The authors identify a U-shaped relationship between Ht and 28-day mortality,
highlighting both low and high levels of Ht as independent predictors of adverse outcomes.
Non-linear regression analyses further substantiate the findings, suggesting that Ht could be an
important parameter in prognostic evaluations.
This study adds little novelty to the existing literature, as the association between hematocrit
and outcomes in AP has been well-established since the publication of the Ranson criteria in
1974. The Ranson scoring system, a widely used prognostic tool for AP, incorporates Ht as an
indicator of hemoconcentration, a marker of disease severity. High hematocrit is linked to fluid
loss and hypovolemia, while low levels often result from aggressive fluid resuscitation. These
relationships have been extensively documented in the context of AP severity and mortality.
A notable omission is the lack of citation of the Ranson criteria, which for decades has
included hematocrit as part of its scoring methodology. Ranson's criteria serve as a foundational
framework for predicting outcomes in AP, encompassing parameters like age, glucose, and Ht
changes over 48 hours. Ignoring this critical context weakens the study’s claim of providing
new insights, as the primary associations have long been known and remain clinically relevant.
Given the absence of novel findings and the failure to adequately contextualize the study within
existing literature, I recommend against publication. The study’s conclusion that Ht correlates
with mortality in AP reiterates what has been known for nearly five decades without offering
new mechanistic insights, innovative methodologies, or significant clinical implications. This
lack of originality diminishes the paper's contribution to advancing the field.
assistant