Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 0 Date: 22 Sep 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Because connection of sleeping disorders with fibrosis development has been already studied
based on NHANES data authors tried to enter dietary fiber consumption in the equation The
abstract methods should be changed determining that connection of sleeping patern with fibrosis
development was evaluated taking into consideration fiber consumption  (dichotomus analysis),
age, gender and presence of CVD If there is space they should also mention that patients with
ALD, MeLD or hepatitis were excluded. Data on severity of fibrosis could be provided in
the result section In results findings of multivariated analysis should be presented Intergroup
comparisons could be omitted. Methods Authors should define of social jet lag and sleering
debt were taken into consideration If those parameters were taken into consideration they should
be defined Authors should exclude patients with MASLD and viral hepatitis and those with
ALD or MeLD since alcohol consumption can affect sleeping paterns ; in the same way that
the previous NHANES study did.  A stepwise analysis should be performed if the effect  of
various paremeters need to be evaluated. Exclusion criteria should be removed from the results
to methods section and there a table with a reference in the text for the whole number excluded
is enough Data on fibrosis severity might be given in the text In the text should appear all
significant parameters Findings of univariate analysis should be presented in a table, as well
as those of multivariated analysis and only significant variabled should appear in the text For
fiber consumption a comment should be provided about the result if parametric evaluation was
performed and then it should be given the result of non-parametric (dichotomised by 14.7 g/d)
analysis The stepwise analysis should be preferably replaced by another connecting risk factors
with F3 fibrosis or even cirrhosis Discussion should be adapted accordingly
Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 0 Date: 22 Sep 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Because connection of sleeping disorders with fibrosis development has been already studied
based on NHANES data authors tried to enter dietary fiber consumption in the equation The
abstract methods should be changed determining that connection of sleeping patern with fibrosis
development was evaluated taking into consideration fiber consumption  (dichotomus analysis),
age, gender and presence of CVD If there is space they should also mention that patients with
ALD, MeLD or hepatitis were excluded. Data on severity of fibrosis could be provided in
the result section In results findings of multivariated analysis should be presented Intergroup
comparisons could be omitted. Methods Authors should define of social jet lag and sleering
debt were taken into consideration If those parameters were taken into consideration they should
be defined Authors should exclude patients with MASLD and viral hepatitis and those with
ALD or MeLD since alcohol consumption can affect sleeping paterns ; in the same way that
the previous NHANES study did.  A stepwise analysis should be performed if the effect  of
various paremeters need to be evaluated. Exclusion criteria should be removed from the results
to methods section and there a table with a reference in the text for the whole number excluded
is enough Data on fibrosis severity might be given in the text In the text should appear all
significant parameters Findings of univariate analysis should be presented in a table, as well
as those of multivariated analysis and only significant variabled should appear in the text For
fiber consumption a comment should be provided about the result if parametric evaluation was
performed and then it should be given the result of non-parametric (dichotomised by 14.7 g/d)
analysis The stepwise analysis should be preferably replaced by another connecting risk factors
with F3 fibrosis or even cirrhosis Discussion should be adapted accordingly
Please review this paper.
user
Title: The moderating effect of dietary fiber intake on the association between sleep pattern and
liver fibrosis in metabolic dysfunction-associated steatotic liver disease: a study from NHANES
Version: 0 Date: 22 Sep 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
Because connection of sleeping disorders with fibrosis development has been already studied
based on NHANES data authors tried to enter dietary fiber consumption in the equation The
abstract methods should be changed determining that connection of sleeping patern with fibrosis
development was evaluated taking into consideration fiber consumption  (dichotomus analysis),
age, gender and presence of CVD If there is space they should also mention that patients with
ALD, MeLD or hepatitis were excluded. Data on severity of fibrosis could be provided in
the result section In results findings of multivariated analysis should be presented Intergroup
comparisons could be omitted. Methods Authors should define of social jet lag and sleering
debt were taken into consideration If those parameters were taken into consideration they should
be defined Authors should exclude patients with MASLD and viral hepatitis and those with
ALD or MeLD since alcohol consumption can affect sleeping paterns ; in the same way that
the previous NHANES study did.  A stepwise analysis should be performed if the effect  of
various paremeters need to be evaluated. Exclusion criteria should be removed from the results
to methods section and there a table with a reference in the text for the whole number excluded
is enough Data on fibrosis severity might be given in the text In the text should appear all
significant parameters Findings of univariate analysis should be presented in a table, as well
as those of multivariated analysis and only significant variabled should appear in the text For
fiber consumption a comment should be provided about the result if parametric evaluation was
performed and then it should be given the result of non-parametric (dichotomised by 14.7 g/d)
analysis The stepwise analysis should be preferably replaced by another connecting risk factors
with F3 fibrosis or even cirrhosis Discussion should be adapted accordingly
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