Reviewer's report
Title:Gastric cancer is associated with NOS2 -954G/C polymorphism and
environmental factors in a Brazilian population
Version: 2Date:2 April 2010
Reviewer: Asahi Hishida
Reviewer's report:
While the authors (Jorge YC et al.) revised their manuscript according to the
reviewers’ comments, however, this reviewer thinks that the following points
should be re-evaluated and then revised.
<Major Compulsory Revisions>
Again, the results in Table 2 seem to be the inverse. If the OR’s were calculated
using a dominant model, the crude OR of GA in subjects with GC+CC of NOS2
-954G/C polymorphism should be {(62+11)x115}/{(38+11)x77} = 2.2, much larger
than 0.67 (may be the inverse). The OR of GA for the C allele of the NOS2 -954
G/C polymorphism is calculated as (0.29x0.82) / (0.18x0.71) = 1.86, in the same
way. The authors should check these values carefully over again.
<Minor Essential Revisions>
1. (Page 3, paragraph 2) The steps leading to H. pylori-related gastric cancer
should be described more precisely, like as H. pylori infection, gastric atrophy
development, intestinal metaplasia, dysplasia, and carcinogenesis (also please
make reference to Correa P., CancerRes 1988; 48: 3554-60).
2. “p=0.00” seems odd and unclear, which should be replaced with “p<0.01”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Gastric cancer is associated with NOS2 -954G/C polymorphism and
environmental factors in a Brazilian population
Version: 2Date:2 April 2010
Reviewer: Asahi Hishida
Reviewer's report:
While the authors (Jorge YC et al.) revised their manuscript according to the
reviewers’ comments, however, this reviewer thinks that the following points
should be re-evaluated and then revised.
<Major Compulsory Revisions>
Again, the results in Table 2 seem to be the inverse. If the OR’s were calculated
using a dominant model, the crude OR of GA in subjects with GC+CC of NOS2
-954G/C polymorphism should be {(62+11)x115}/{(38+11)x77} = 2.2, much larger
than 0.67 (may be the inverse). The OR of GA for the C allele of the NOS2 -954
G/C polymorphism is calculated as (0.29x0.82) / (0.18x0.71) = 1.86, in the same
way. The authors should check these values carefully over again.
<Minor Essential Revisions>
1. (Page 3, paragraph 2) The steps leading to H. pylori-related gastric cancer
should be described more precisely, like as H. pylori infection, gastric atrophy
development, intestinal metaplasia, dysplasia, and carcinogenesis (also please
make reference to Correa P., CancerRes 1988; 48: 3554-60).
2. “p=0.00” seems odd and unclear, which should be replaced with “p<0.01”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Gastric cancer is associated with NOS2 -954G/C polymorphism and
environmental factors in a Brazilian population
Version: 2Date:2 April 2010
Reviewer: Asahi Hishida
Reviewer's report:
While the authors (Jorge YC et al.) revised their manuscript according to the
reviewers’ comments, however, this reviewer thinks that the following points
should be re-evaluated and then revised.
<Major Compulsory Revisions>
Again, the results in Table 2 seem to be the inverse. If the OR’s were calculated
using a dominant model, the crude OR of GA in subjects with GC+CC of NOS2
-954G/C polymorphism should be {(62+11)x115}/{(38+11)x77} = 2.2, much larger
than 0.67 (may be the inverse). The OR of GA for the C allele of the NOS2 -954
G/C polymorphism is calculated as (0.29x0.82) / (0.18x0.71) = 1.86, in the same
way. The authors should check these values carefully over again.
<Minor Essential Revisions>
1. (Page 3, paragraph 2) The steps leading to H. pylori-related gastric cancer
should be described more precisely, like as H. pylori infection, gastric atrophy
development, intestinal metaplasia, dysplasia, and carcinogenesis (also please
make reference to Correa P., CancerRes 1988; 48: 3554-60).
2. “p=0.00” seems odd and unclear, which should be replaced with “p<0.01”.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant