Reviewer's report
Title:Endocytoscopic findings of lymphomas of the stomach
Version: 2Date:28 December 2012
Reviewer: Emanuele Meroni
Reviewer's report:
This manuscript summarizes results of an interesting case series which suggests
that endocytoscopy have a possible impact on clinical management of
lymphomas involving the stomach.
The following revisions are suggested :
1) Major compulsory revision
In Methods section, Authors should explain how they overcame technical
difficulty in targeting biopsies following endocytoscopic observation. In fact, if
compared to a through-the-scope endocytoscopy (ECS) probe, an integrated
prototype raises the issue of assessing a pinpoint correlation between the area of
mucosa observed and the area samples for histology, providing the confirm of
endocytoscopic findings. Operative channel of the integrated endocytoscope is
parallel to the ECS system, thus making it more difficult to target biopsies of the
mucosa explored. The task is much easier when using the probe, since biopsy
forceps is introduced through the channel immediately after removing the ECS
probe.
2) Minor essential revision
in Methods section, it would be advisable to state whether the study is
prospective or retrospective. Besides this, is it a series of consecutive patients ?
How were they recruited ?
3) Minor essential revisions
Word corrections needed :
Page 2, line 11 : MALT lymphoma cases
Page 4, line 18 : …may vary among mass-forming….
Page 7, line 11 : …histopathological…
Page 8, line 1 : …underwent repeated endocytoscopy…
Page 8, line 22 : . …histopathological…
Page 8, line 23 : …lamina propria…
Page 11, line 5 : …there were crowded cellular elements….
Page 12, line 8 : .. repeated endocytoscopic….
Page 12, line 18 : It has been reported….
Page 13, line 3 :…responsiveness for anti-tumor therapies…
Page 13, line 12 & 13 : Endocytoscopy virtually enables histopathological
differential diagnosis for lymphoproliferative disorders and their clinical
assessment….
Page 13, line 19 : …..CR, complete remission….
Page 13, line 23 : No disclosures
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Endocytoscopic findings of lymphomas of the stomach
Version: 2Date:28 December 2012
Reviewer: Emanuele Meroni
Reviewer's report:
This manuscript summarizes results of an interesting case series which suggests
that endocytoscopy have a possible impact on clinical management of
lymphomas involving the stomach.
The following revisions are suggested :
1) Major compulsory revision
In Methods section, Authors should explain how they overcame technical
difficulty in targeting biopsies following endocytoscopic observation. In fact, if
compared to a through-the-scope endocytoscopy (ECS) probe, an integrated
prototype raises the issue of assessing a pinpoint correlation between the area of
mucosa observed and the area samples for histology, providing the confirm of
endocytoscopic findings. Operative channel of the integrated endocytoscope is
parallel to the ECS system, thus making it more difficult to target biopsies of the
mucosa explored. The task is much easier when using the probe, since biopsy
forceps is introduced through the channel immediately after removing the ECS
probe.
2) Minor essential revision
in Methods section, it would be advisable to state whether the study is
prospective or retrospective. Besides this, is it a series of consecutive patients ?
How were they recruited ?
3) Minor essential revisions
Word corrections needed :
Page 2, line 11 : MALT lymphoma cases
Page 4, line 18 : …may vary among mass-forming….
Page 7, line 11 : …histopathological…
Page 8, line 1 : …underwent repeated endocytoscopy…
Page 8, line 22 : . …histopathological…
Page 8, line 23 : …lamina propria…
Page 11, line 5 : …there were crowded cellular elements….
Page 12, line 8 : .. repeated endocytoscopic….
Page 12, line 18 : It has been reported….
Page 13, line 3 :…responsiveness for anti-tumor therapies…
Page 13, line 12 & 13 : Endocytoscopy virtually enables histopathological
differential diagnosis for lymphoproliferative disorders and their clinical
assessment….
Page 13, line 19 : …..CR, complete remission….
Page 13, line 23 : No disclosures
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Endocytoscopic findings of lymphomas of the stomach
Version: 2Date:28 December 2012
Reviewer: Emanuele Meroni
Reviewer's report:
This manuscript summarizes results of an interesting case series which suggests
that endocytoscopy have a possible impact on clinical management of
lymphomas involving the stomach.
The following revisions are suggested :
1) Major compulsory revision
In Methods section, Authors should explain how they overcame technical
difficulty in targeting biopsies following endocytoscopic observation. In fact, if
compared to a through-the-scope endocytoscopy (ECS) probe, an integrated
prototype raises the issue of assessing a pinpoint correlation between the area of
mucosa observed and the area samples for histology, providing the confirm of
endocytoscopic findings. Operative channel of the integrated endocytoscope is
parallel to the ECS system, thus making it more difficult to target biopsies of the
mucosa explored. The task is much easier when using the probe, since biopsy
forceps is introduced through the channel immediately after removing the ECS
probe.
2) Minor essential revision
in Methods section, it would be advisable to state whether the study is
prospective or retrospective. Besides this, is it a series of consecutive patients ?
How were they recruited ?
3) Minor essential revisions
Word corrections needed :
Page 2, line 11 : MALT lymphoma cases
Page 4, line 18 : …may vary among mass-forming….
Page 7, line 11 : …histopathological…
Page 8, line 1 : …underwent repeated endocytoscopy…
Page 8, line 22 : . …histopathological…
Page 8, line 23 : …lamina propria…
Page 11, line 5 : …there were crowded cellular elements….
Page 12, line 8 : .. repeated endocytoscopic….
Page 12, line 18 : It has been reported….
Page 13, line 3 :…responsiveness for anti-tumor therapies…
Page 13, line 12 & 13 : Endocytoscopy virtually enables histopathological
differential diagnosis for lymphoproliferative disorders and their clinical
assessment….
Page 13, line 19 : …..CR, complete remission….
Page 13, line 23 : No disclosures
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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