Title: Genetic estimation of causalities between educational attainment with common digestive
tract diseases and the mediating pathways
Version: 2 Date: 04 Jul 2024
Reviewer's report:
1.  The study primarily used data from European ancestry populations, which may limit the
generalizability of findings to other ethnic groups.
2. After applying the Benjamini-Hochberg adjustment for multiple testing, some of the estimated
causal effects (e.g., WHR on peptic ulcer and fasting insulin on cholelithiasis) became only
borderline significant. This suggests that these specific findings may be less robust and require
further validation.
3. The direct impact of education on non-alcoholic fatty liver disease (NAFLD) weakened
towards null when adjusting for intelligence and cognition. However, the authors note this
could be due to limited sample size, as the combined sample for NAFLD was less than 4,000
individuals .
4. Inability to account for all potential confounders; While Mendelian randomization helps
minimize confounding, it cannot completely rule out all potential confounding factor
Title: Genetic estimation of causalities between educational attainment with common digestive
tract diseases and the mediating pathways
Version: 2 Date: 04 Jul 2024
Reviewer's report:
1.  The study primarily used data from European ancestry populations, which may limit the
generalizability of findings to other ethnic groups.
2. After applying the Benjamini-Hochberg adjustment for multiple testing, some of the estimated
causal effects (e.g., WHR on peptic ulcer and fasting insulin on cholelithiasis) became only
borderline significant. This suggests that these specific findings may be less robust and require
further validation.
3. The direct impact of education on non-alcoholic fatty liver disease (NAFLD) weakened
towards null when adjusting for intelligence and cognition. However, the authors note this
could be due to limited sample size, as the combined sample for NAFLD was less than 4,000
individuals .
4. Inability to account for all potential confounders; While Mendelian randomization helps
minimize confounding, it cannot completely rule out all potential confounding factor
Please review this paper.
user
Title: Genetic estimation of causalities between educational attainment with common digestive
tract diseases and the mediating pathways
Version: 2 Date: 04 Jul 2024
Reviewer's report:
1.  The study primarily used data from European ancestry populations, which may limit the
generalizability of findings to other ethnic groups.
2. After applying the Benjamini-Hochberg adjustment for multiple testing, some of the estimated
causal effects (e.g., WHR on peptic ulcer and fasting insulin on cholelithiasis) became only
borderline significant. This suggests that these specific findings may be less robust and require
further validation.
3. The direct impact of education on non-alcoholic fatty liver disease (NAFLD) weakened
towards null when adjusting for intelligence and cognition. However, the authors note this
could be due to limited sample size, as the combined sample for NAFLD was less than 4,000
individuals .
4. Inability to account for all potential confounders; While Mendelian randomization helps
minimize confounding, it cannot completely rule out all potential confounding factor
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