Title: Metabolic Dysfunction, Cirrhosis, and HCV Genotype 3a Drive Type 2 Diabetes Risk in
Chronic Hepatitis C: A Southern Chinese Cohort Study
Version: 3 Date: 02 Jun 2025
Reviewer's report:
The study addresses the increasingly recognized extrahepatic manifestations of HCV infection,
particularly T2DM, and its clinical risk factors. Regarding study design, multivariate logistic
regression enhances causal inferences, while the 1:1 matched case-control approach lessens
confounding. The materials and methods are well structured, and the results can be easily
tracked.
On the other hand, there are consistent problems in punctuation, grammar, and word choice
that make the text difficult to read. Also, in the results section, HOMA-IR has an OR < 1 in
multivariate analysis, indicating a protective effect that defies previous research and clinical
expectations. It is necessary to explain this disparity. Genotyping was only performed on
44 patients with CHC+T2DM, which may not provide robust statistical power for subgroup
analysis. I suggest adding to limitations. The discussion is repetitive and could be condensed.
Several paragraphs reiterate previous findings without adding new interpretation.
Finally, I observed that the manuscript alternates between “HCH” and “CHC,” “T2DM” and
diabetes. It is necessary to use consistent terminology all throughout.
Title: Metabolic Dysfunction, Cirrhosis, and HCV Genotype 3a Drive Type 2 Diabetes Risk in
Chronic Hepatitis C: A Southern Chinese Cohort Study
Version: 3 Date: 02 Jun 2025
Reviewer's report:
The study addresses the increasingly recognized extrahepatic manifestations of HCV infection,
particularly T2DM, and its clinical risk factors. Regarding study design, multivariate logistic
regression enhances causal inferences, while the 1:1 matched case-control approach lessens
confounding. The materials and methods are well structured, and the results can be easily
tracked.
On the other hand, there are consistent problems in punctuation, grammar, and word choice
that make the text difficult to read. Also, in the results section, HOMA-IR has an OR < 1 in
multivariate analysis, indicating a protective effect that defies previous research and clinical
expectations. It is necessary to explain this disparity. Genotyping was only performed on
44 patients with CHC+T2DM, which may not provide robust statistical power for subgroup
analysis. I suggest adding to limitations. The discussion is repetitive and could be condensed.
Several paragraphs reiterate previous findings without adding new interpretation.
Finally, I observed that the manuscript alternates between “HCH” and “CHC,” “T2DM” and
diabetes. It is necessary to use consistent terminology all throughout.
Please review this paper.
user
Title: Metabolic Dysfunction, Cirrhosis, and HCV Genotype 3a Drive Type 2 Diabetes Risk in
Chronic Hepatitis C: A Southern Chinese Cohort Study
Version: 3 Date: 02 Jun 2025
Reviewer's report:
The study addresses the increasingly recognized extrahepatic manifestations of HCV infection,
particularly T2DM, and its clinical risk factors. Regarding study design, multivariate logistic
regression enhances causal inferences, while the 1:1 matched case-control approach lessens
confounding. The materials and methods are well structured, and the results can be easily
tracked.
On the other hand, there are consistent problems in punctuation, grammar, and word choice
that make the text difficult to read. Also, in the results section, HOMA-IR has an OR < 1 in
multivariate analysis, indicating a protective effect that defies previous research and clinical
expectations. It is necessary to explain this disparity. Genotyping was only performed on
44 patients with CHC+T2DM, which may not provide robust statistical power for subgroup
analysis. I suggest adding to limitations. The discussion is repetitive and could be condensed.
Several paragraphs reiterate previous findings without adding new interpretation.
Finally, I observed that the manuscript alternates between “HCH” and “CHC,” “T2DM” and
diabetes. It is necessary to use consistent terminology all throughout.
assistant