Title: Lower end of treatment HBsAg and HBcrAg were associated with HBsAg loss after
nucleos(t)ide analog cessation
Version: 1 Date: 06 Mar 2023
Reviewer's report:
title: do not include cut off values of hbsag etc in your title.
Introduction:  too long, try to be more concrete.
Methods:
- describe which tests were used for HBV DNA, HBV RNA and HBcrAg quantification,
including lower limit of detection. Not solely refer to your previous published paper.
- summarize the Chinese NA stop criteria
- include re-treatment criteria
- can you include an ethical statement, did every patient give written consent?
- include your endpoints
Results:
- give patient characteristics. Do not refer to your previous published paper.
- it suggests that many HBV RNA data is missing during follow-up. Please state of how many
patients data was available regarding HBV RNA. Plus include this in your limitation section
- table  1:  HBV RNA is 0 log. But this is an impossible  value. Please re-check.
-  regarding group B: 19 patients is a very small group to draw conclusions from. Include this
in your discussion.
discussion: discuss not only results from other studies, but also try to explain the rationale behind
the differences and/or similarities with your results.
English: check grammar and be consistent for the use of British vs America English.
Title: Lower end of treatment HBsAg and HBcrAg were associated with HBsAg loss after
nucleos(t)ide analog cessation
Version: 1 Date: 06 Mar 2023
Reviewer's report:
title: do not include cut off values of hbsag etc in your title.
Introduction:  too long, try to be more concrete.
Methods:
- describe which tests were used for HBV DNA, HBV RNA and HBcrAg quantification,
including lower limit of detection. Not solely refer to your previous published paper.
- summarize the Chinese NA stop criteria
- include re-treatment criteria
- can you include an ethical statement, did every patient give written consent?
- include your endpoints
Results:
- give patient characteristics. Do not refer to your previous published paper.
- it suggests that many HBV RNA data is missing during follow-up. Please state of how many
patients data was available regarding HBV RNA. Plus include this in your limitation section
- table  1:  HBV RNA is 0 log. But this is an impossible  value. Please re-check.
-  regarding group B: 19 patients is a very small group to draw conclusions from. Include this
in your discussion.
discussion: discuss not only results from other studies, but also try to explain the rationale behind
the differences and/or similarities with your results.
English: check grammar and be consistent for the use of British vs America English.
Please review this paper.
user
Title: Lower end of treatment HBsAg and HBcrAg were associated with HBsAg loss after
nucleos(t)ide analog cessation
Version: 1 Date: 06 Mar 2023
Reviewer's report:
title: do not include cut off values of hbsag etc in your title.
Introduction:  too long, try to be more concrete.
Methods:
- describe which tests were used for HBV DNA, HBV RNA and HBcrAg quantification,
including lower limit of detection. Not solely refer to your previous published paper.
- summarize the Chinese NA stop criteria
- include re-treatment criteria
- can you include an ethical statement, did every patient give written consent?
- include your endpoints
Results:
- give patient characteristics. Do not refer to your previous published paper.
- it suggests that many HBV RNA data is missing during follow-up. Please state of how many
patients data was available regarding HBV RNA. Plus include this in your limitation section
- table  1:  HBV RNA is 0 log. But this is an impossible  value. Please re-check.
-  regarding group B: 19 patients is a very small group to draw conclusions from. Include this
in your discussion.
discussion: discuss not only results from other studies, but also try to explain the rationale behind
the differences and/or similarities with your results.
English: check grammar and be consistent for the use of British vs America English.
assistant