Title: Amyloid A and lactic acid as a predictor in patients with sepsis in patients with liver
cirrhosis
Version: 1 Date: 19 Jan 2024
Reviewer:  Haidi Karam-Allah Ramadan
Reviewer's report:
In this article, the authors wanted to assess the risk factors of sepsis in patients with liver cirrhosis
and to identify the prognostic role of serum amyloid A/Lactate ratio in these patients. The
study included patients with cirrhosis and sepsis as cases and cirrhosis without sepsis as control.
However some comments are to be addressed.
1. In the title, we don't mention the type of the used statistical test, besides the word "in patients"
is repeated twice. This makes the title weak and not understandable.
2. In the introduction, the authors didn't mention any paragraphs on amyloid A or lactate and
its relation to sepsis.
3. In the methods, the authors recruited a big number of control (3 fold that of cases), which
could result in statistical errors. How was the sample size calculated in this study?
4. Exclusion of patients who had no history of antibiotic exposure is not correct, because
sepsis could occur after many community acquired infections in those vulnerable patients before
receiving antibiotics.
5. Similarly, the authors excluded patients with gastric or lung malignancies but didn't exclude
patients with HCC which could be a cause of mortality away from sepsis.
6. English editing is highly required for the manuscript.
Title: Amyloid A and lactic acid as a predictor in patients with sepsis in patients with liver
cirrhosis
Version: 1 Date: 19 Jan 2024
Reviewer:  Haidi Karam-Allah Ramadan
Reviewer's report:
In this article, the authors wanted to assess the risk factors of sepsis in patients with liver cirrhosis
and to identify the prognostic role of serum amyloid A/Lactate ratio in these patients. The
study included patients with cirrhosis and sepsis as cases and cirrhosis without sepsis as control.
However some comments are to be addressed.
1. In the title, we don't mention the type of the used statistical test, besides the word "in patients"
is repeated twice. This makes the title weak and not understandable.
2. In the introduction, the authors didn't mention any paragraphs on amyloid A or lactate and
its relation to sepsis.
3. In the methods, the authors recruited a big number of control (3 fold that of cases), which
could result in statistical errors. How was the sample size calculated in this study?
4. Exclusion of patients who had no history of antibiotic exposure is not correct, because
sepsis could occur after many community acquired infections in those vulnerable patients before
receiving antibiotics.
5. Similarly, the authors excluded patients with gastric or lung malignancies but didn't exclude
patients with HCC which could be a cause of mortality away from sepsis.
6. English editing is highly required for the manuscript.
Please review this paper.
user
Title: Amyloid A and lactic acid as a predictor in patients with sepsis in patients with liver
cirrhosis
Version: 1 Date: 19 Jan 2024
Reviewer:  Haidi Karam-Allah Ramadan
Reviewer's report:
In this article, the authors wanted to assess the risk factors of sepsis in patients with liver cirrhosis
and to identify the prognostic role of serum amyloid A/Lactate ratio in these patients. The
study included patients with cirrhosis and sepsis as cases and cirrhosis without sepsis as control.
However some comments are to be addressed.
1. In the title, we don't mention the type of the used statistical test, besides the word "in patients"
is repeated twice. This makes the title weak and not understandable.
2. In the introduction, the authors didn't mention any paragraphs on amyloid A or lactate and
its relation to sepsis.
3. In the methods, the authors recruited a big number of control (3 fold that of cases), which
could result in statistical errors. How was the sample size calculated in this study?
4. Exclusion of patients who had no history of antibiotic exposure is not correct, because
sepsis could occur after many community acquired infections in those vulnerable patients before
receiving antibiotics.
5. Similarly, the authors excluded patients with gastric or lung malignancies but didn't exclude
patients with HCC which could be a cause of mortality away from sepsis.
6. English editing is highly required for the manuscript.
assistant