Title: Assessing Clinical Trial Failure Risk Factors And Reasons In Gastric Cancer
Version: 1 Date: 13 Aug 2022
Reviewer's report:
This study aimed to analyze the rate and the reason for failure of gastric cancer trails and estimate
potential risk factors related to trial failure.
General comment
The reviewer believes that studies with small anticipated accrual number treat rare condition
and/or they have limited inclusion criteria, which may cause difficulty in recruiting patients and
those studies may end up with trial failure. The authors should discuss this.
Specific comments
Abstract, Conclusion
Conclusion on the risk factor of the trial failure is unclear. It should be stated more clearly.
Methods
What do “multiple cancer types” mean?
Page 6, line 16
Enrol should be enroll.
Page 7, line 2
Accural should be accrual.
Some sentences or words lack spaces in between.
Fig. 4
Numbers at risk should be added to the Kaplan-Meier curve.
Conclusion
This is also unclear and what the authors write in the section in one of the limitations of this
study. In “Conclusion” section, the thing that the authors conclude from their analysis should
be clearly stated.
Title: Assessing Clinical Trial Failure Risk Factors And Reasons In Gastric Cancer
Version: 1 Date: 13 Aug 2022
Reviewer's report:
This study aimed to analyze the rate and the reason for failure of gastric cancer trails and estimate
potential risk factors related to trial failure.
General comment
The reviewer believes that studies with small anticipated accrual number treat rare condition
and/or they have limited inclusion criteria, which may cause difficulty in recruiting patients and
those studies may end up with trial failure. The authors should discuss this.
Specific comments
Abstract, Conclusion
Conclusion on the risk factor of the trial failure is unclear. It should be stated more clearly.
Methods
What do “multiple cancer types” mean?
Page 6, line 16
Enrol should be enroll.
Page 7, line 2
Accural should be accrual.
Some sentences or words lack spaces in between.
Fig. 4
Numbers at risk should be added to the Kaplan-Meier curve.
Conclusion
This is also unclear and what the authors write in the section in one of the limitations of this
study. In “Conclusion” section, the thing that the authors conclude from their analysis should
be clearly stated.
Please review this paper.
user
Title: Assessing Clinical Trial Failure Risk Factors And Reasons In Gastric Cancer
Version: 1 Date: 13 Aug 2022
Reviewer's report:
This study aimed to analyze the rate and the reason for failure of gastric cancer trails and estimate
potential risk factors related to trial failure.
General comment
The reviewer believes that studies with small anticipated accrual number treat rare condition
and/or they have limited inclusion criteria, which may cause difficulty in recruiting patients and
those studies may end up with trial failure. The authors should discuss this.
Specific comments
Abstract, Conclusion
Conclusion on the risk factor of the trial failure is unclear. It should be stated more clearly.
Methods
What do “multiple cancer types” mean?
Page 6, line 16
Enrol should be enroll.
Page 7, line 2
Accural should be accrual.
Some sentences or words lack spaces in between.
Fig. 4
Numbers at risk should be added to the Kaplan-Meier curve.
Conclusion
This is also unclear and what the authors write in the section in one of the limitations of this
study. In “Conclusion” section, the thing that the authors conclude from their analysis should
be clearly stated.
assistant