Title: Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with
gastric cancer
Version: 1 Date: 04 Sep 2021
Reviewer:  Anders Grubb
Reviewer's report:
The manuscript by Sun et al. contains new and relevant information concerning the use of the
ratio between the levels of creatinine and cystatin C as a marker of sarcopenia in patients with
gastric cancer.
Some references are not the most appropriate ones and should be replaced by more relevant ones.
References 9 and 10 do not contain any information that cystatin C is independent of muscle
mass, or lean tissue mass, and should be replaced, for example, with the references
Vinge E, et al. Relationships among serum cystatin C, serum creatinine, lean tissue mass and
glomerular filtration rate in healthy adults. Scand J Clin Lab Invest 1999;59:587-592.
Grubb A. Cystatin C is indispensable for evaluation of kidney disease. eJIFCC 2017;28:268-276.
http://www.ifcc.org/media/476805/ejifcc2017vol28no4pp268-276.pdf
Reference 39 is used after the sentence: As an indicator of renal function, serum CysC has
recently received greater attention. Serum CysC is a low-molecular-weight protein with a stable
production rate and it can be freely filtered by glomeruli, but this is not shown in this reference. I
suggest that a modern review of cystatin C, for example, "Grubb A. Cystatin C is indispensable
for evaluation of kidney disease. eJIFCC 2017;28:268-276. http://www.ifcc.org/media/476805/
ejifcc2017vol28no4pp268-276.pdf" should replace reference 39 of the present manuscript.
Minor remarks
In tabel 1 "Fmales" should be "Females"
I suggest that "C-index" (concordance index?) is explained.
Title: Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with
gastric cancer
Version: 1 Date: 04 Sep 2021
Reviewer:  Anders Grubb
Reviewer's report:
The manuscript by Sun et al. contains new and relevant information concerning the use of the
ratio between the levels of creatinine and cystatin C as a marker of sarcopenia in patients with
gastric cancer.
Some references are not the most appropriate ones and should be replaced by more relevant ones.
References 9 and 10 do not contain any information that cystatin C is independent of muscle
mass, or lean tissue mass, and should be replaced, for example, with the references
Vinge E, et al. Relationships among serum cystatin C, serum creatinine, lean tissue mass and
glomerular filtration rate in healthy adults. Scand J Clin Lab Invest 1999;59:587-592.
Grubb A. Cystatin C is indispensable for evaluation of kidney disease. eJIFCC 2017;28:268-276.
http://www.ifcc.org/media/476805/ejifcc2017vol28no4pp268-276.pdf
Reference 39 is used after the sentence: As an indicator of renal function, serum CysC has
recently received greater attention. Serum CysC is a low-molecular-weight protein with a stable
production rate and it can be freely filtered by glomeruli, but this is not shown in this reference. I
suggest that a modern review of cystatin C, for example, "Grubb A. Cystatin C is indispensable
for evaluation of kidney disease. eJIFCC 2017;28:268-276. http://www.ifcc.org/media/476805/
ejifcc2017vol28no4pp268-276.pdf" should replace reference 39 of the present manuscript.
Minor remarks
In tabel 1 "Fmales" should be "Females"
I suggest that "C-index" (concordance index?) is explained.
Please review this paper.
user
Title: Serum creatinine/cystatin C ratio as a surrogate marker for sarcopenia in patients with
gastric cancer
Version: 1 Date: 04 Sep 2021
Reviewer:  Anders Grubb
Reviewer's report:
The manuscript by Sun et al. contains new and relevant information concerning the use of the
ratio between the levels of creatinine and cystatin C as a marker of sarcopenia in patients with
gastric cancer.
Some references are not the most appropriate ones and should be replaced by more relevant ones.
References 9 and 10 do not contain any information that cystatin C is independent of muscle
mass, or lean tissue mass, and should be replaced, for example, with the references
Vinge E, et al. Relationships among serum cystatin C, serum creatinine, lean tissue mass and
glomerular filtration rate in healthy adults. Scand J Clin Lab Invest 1999;59:587-592.
Grubb A. Cystatin C is indispensable for evaluation of kidney disease. eJIFCC 2017;28:268-276.
http://www.ifcc.org/media/476805/ejifcc2017vol28no4pp268-276.pdf
Reference 39 is used after the sentence: As an indicator of renal function, serum CysC has
recently received greater attention. Serum CysC is a low-molecular-weight protein with a stable
production rate and it can be freely filtered by glomeruli, but this is not shown in this reference. I
suggest that a modern review of cystatin C, for example, "Grubb A. Cystatin C is indispensable
for evaluation of kidney disease. eJIFCC 2017;28:268-276. http://www.ifcc.org/media/476805/
ejifcc2017vol28no4pp268-276.pdf" should replace reference 39 of the present manuscript.
Minor remarks
In tabel 1 "Fmales" should be "Females"
I suggest that "C-index" (concordance index?) is explained.
assistant