Title: Genetic Associations of Birthweight, Childhood, and Adult BMI with
Metabolic Dysfunction-associated Steatotic liver disease: A Mendelian Randomization
Version: 1 Date: 20 May 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
The study uses SNP data to evaluate any connection of NAFLD with birth and childhood weight
The idea is innovative  The abstract should make clear this innovation as well as diagnosis of
NALFLD As far as metabolic data are available the new diagnosis of MASLD could be used
instead. The authors should define the diagnosis of NAFLD or MASLD Their is a hint that a
national database was used but still criteria of NAFLD should be defined Was the diagnosis
based on liver biopsy, MRI, US or any algorithmic diagnosis The difference is important Also
data on birth and childhood weight should be defined if they are based on a database or if they
represent a certain retrospective recording At what age childhood weight has been recorded
and what was normal  The authors should give a hint about their data not being coherent with
previous bibliography suggesting a relation of birth weight high or low to   NAFLD development
Are there any data about blood sugar or insulin available?
Title: Genetic Associations of Birthweight, Childhood, and Adult BMI with
Metabolic Dysfunction-associated Steatotic liver disease: A Mendelian Randomization
Version: 1 Date: 20 May 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
The study uses SNP data to evaluate any connection of NAFLD with birth and childhood weight
The idea is innovative  The abstract should make clear this innovation as well as diagnosis of
NALFLD As far as metabolic data are available the new diagnosis of MASLD could be used
instead. The authors should define the diagnosis of NAFLD or MASLD Their is a hint that a
national database was used but still criteria of NAFLD should be defined Was the diagnosis
based on liver biopsy, MRI, US or any algorithmic diagnosis The difference is important Also
data on birth and childhood weight should be defined if they are based on a database or if they
represent a certain retrospective recording At what age childhood weight has been recorded
and what was normal  The authors should give a hint about their data not being coherent with
previous bibliography suggesting a relation of birth weight high or low to   NAFLD development
Are there any data about blood sugar or insulin available?
Please review this paper.
user
Title: Genetic Associations of Birthweight, Childhood, and Adult BMI with
Metabolic Dysfunction-associated Steatotic liver disease: A Mendelian Randomization
Version: 1 Date: 20 May 2024
Reviewer:  Panagiotis Tsibouris
Reviewer's report:
The study uses SNP data to evaluate any connection of NAFLD with birth and childhood weight
The idea is innovative  The abstract should make clear this innovation as well as diagnosis of
NALFLD As far as metabolic data are available the new diagnosis of MASLD could be used
instead. The authors should define the diagnosis of NAFLD or MASLD Their is a hint that a
national database was used but still criteria of NAFLD should be defined Was the diagnosis
based on liver biopsy, MRI, US or any algorithmic diagnosis The difference is important Also
data on birth and childhood weight should be defined if they are based on a database or if they
represent a certain retrospective recording At what age childhood weight has been recorded
and what was normal  The authors should give a hint about their data not being coherent with
previous bibliography suggesting a relation of birth weight high or low to   NAFLD development
Are there any data about blood sugar or insulin available?
assistant