Title: Clinicopathological features of early-onset colorectal cancer in Japanese patients: A
single-center retrospective study
Version: 4 Date: 04 Feb 2025
Reviewer's report:
Dear Author,
I have reviewed the submitted manuscript and have the following comments and concerns:
1. Authors should clarify the definitions of OS and DFS. Generally, OS was defined as the time
from the date of surgery to the date of death from any cause in the surgical cases. However, in
this study, patients who did not undergo operation were also included.
2. In advanced stage cases, the prognosis of only the resectable group or only the unresectable
group should also be compared.
Title: Clinicopathological features of early-onset colorectal cancer in Japanese patients: A
single-center retrospective study
Version: 4 Date: 04 Feb 2025
Reviewer's report:
Dear Author,
I have reviewed the submitted manuscript and have the following comments and concerns:
1. Authors should clarify the definitions of OS and DFS. Generally, OS was defined as the time
from the date of surgery to the date of death from any cause in the surgical cases. However, in
this study, patients who did not undergo operation were also included.
2. In advanced stage cases, the prognosis of only the resectable group or only the unresectable
group should also be compared.
Please review this paper.
user
Title: Clinicopathological features of early-onset colorectal cancer in Japanese patients: A
single-center retrospective study
Version: 4 Date: 04 Feb 2025
Reviewer's report:
Dear Author,
I have reviewed the submitted manuscript and have the following comments and concerns:
1. Authors should clarify the definitions of OS and DFS. Generally, OS was defined as the time
from the date of surgery to the date of death from any cause in the surgical cases. However, in
this study, patients who did not undergo operation were also included.
2. In advanced stage cases, the prognosis of only the resectable group or only the unresectable
group should also be compared.
assistant