Reviewer ’s report  
 
Title: Does the Intestinal Microbial Community of Korean Crohn's Disease Patients Differ from 
That of Western Patients?  
 
 
Version: 0 Date: 21 Dec 2015  
 
 
Reviewer: Quanjiang Dong  
 
 
Reviewer's report:  
 
Dear Editor:  
 
The manuscript by Kim JF et al. presen ts a study of characterizing intestinal microbiota in 
Korean CD pts and attempted to investigate the impacts of anti -TNF treatment on microbiota. 
The design of study appears to be sound. The paper is understandable although there are some 
language problems . The results is probably of interest. I would recommend for accepting 
publication if they cound revise following issues.  
 
1. Provide results of statistical analyses when comparing the microbitoa between CD and 
controls (P8 -P9).  
 
2. The compositions at the phylum level have been illustrated in Figure 1 and 2, but this is 
repeatedly presented in Figure 3.    
 
 
  
Quanjiang Dong MD PhD  
Qingdao Municipal Hospital  
Shandong  
China  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
Are the conclusions drawn ade quately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical  review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five y ears received reimbursements, fees, funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may i n any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along  with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report  can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Does the Intestinal Microbial Community of Korean Crohn's Disease Patients Differ from 
That of Western Patients?  
 
 
Version: 0 Date: 21 Dec 2015  
 
 
Reviewer: Quanjiang Dong  
 
 
Reviewer's report:  
 
Dear Editor:  
 
The manuscript by Kim JF et al. presen ts a study of characterizing intestinal microbiota in 
Korean CD pts and attempted to investigate the impacts of anti -TNF treatment on microbiota. 
The design of study appears to be sound. The paper is understandable although there are some 
language problems . The results is probably of interest. I would recommend for accepting 
publication if they cound revise following issues.  
 
1. Provide results of statistical analyses when comparing the microbitoa between CD and 
controls (P8 -P9).  
 
2. The compositions at the phylum level have been illustrated in Figure 1 and 2, but this is 
repeatedly presented in Figure 3.    
 
 
  
Quanjiang Dong MD PhD  
Qingdao Municipal Hospital  
Shandong  
China  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
Are the conclusions drawn ade quately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical  review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five y ears received reimbursements, fees, funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may i n any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along  with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report  can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Does the Intestinal Microbial Community of Korean Crohn's Disease Patients Differ from 
That of Western Patients?  
 
 
Version: 0 Date: 21 Dec 2015  
 
 
Reviewer: Quanjiang Dong  
 
 
Reviewer's report:  
 
Dear Editor:  
 
The manuscript by Kim JF et al. presen ts a study of characterizing intestinal microbiota in 
Korean CD pts and attempted to investigate the impacts of anti -TNF treatment on microbiota. 
The design of study appears to be sound. The paper is understandable although there are some 
language problems . The results is probably of interest. I would recommend for accepting 
publication if they cound revise following issues.  
 
1. Provide results of statistical analyses when comparing the microbitoa between CD and 
controls (P8 -P9).  
 
2. The compositions at the phylum level have been illustrated in Figure 1 and 2, but this is 
repeatedly presented in Figure 3.    
 
 
  
Quanjiang Dong MD PhD  
Qingdao Municipal Hospital  
Shandong  
China  
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
Are the conclusions drawn ade quately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical  review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five y ears received reimbursements, fees, funding, or salary from 
an organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may i n any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial com peting interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along  with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report  can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant