Title: Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021
Version: 2 Date: 28 May 2025
Reviewer's report:
This manuscript assesses the global burden of early-onset gallbladder and biliary tract cancer
(EOGBTC) from 1990 to 2021, particularly among individuals under 50 years old. By utilizing
data from the Global Burden of Disease Study 2021, the authors calculate average annual
percentage changes (AAPCs) and age-standardized rates (ASRs) to analyze trends in prevalence,
incidence, mortality, and disability-adjusted life years (DALYs) associated with EOGBTC.
The findings reveal over 24,555 prevalent cases, 13,611 new cases, and approximately 8,777
deaths due to EOGBTC in 2021. Notably, East Asia and South Asia exhibit the highest disease
burdens, predominantly affecting populations in regions with middle, low-middle, and low
Sociodemographic Index (SDI). The study indicates that although the incidence and prevalence
rates are increasing, mortality and DALY rates show a declining trend. The authors utilize
statistical models, including decomposition analysis and health inequality assessments, to
elucidate the findings and forecast future trends, emphasizing the need for innovative healthcare
strategies to address this significant health challenge.
Title: Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021
Version: 2 Date: 28 May 2025
Reviewer's report:
This manuscript assesses the global burden of early-onset gallbladder and biliary tract cancer
(EOGBTC) from 1990 to 2021, particularly among individuals under 50 years old. By utilizing
data from the Global Burden of Disease Study 2021, the authors calculate average annual
percentage changes (AAPCs) and age-standardized rates (ASRs) to analyze trends in prevalence,
incidence, mortality, and disability-adjusted life years (DALYs) associated with EOGBTC.
The findings reveal over 24,555 prevalent cases, 13,611 new cases, and approximately 8,777
deaths due to EOGBTC in 2021. Notably, East Asia and South Asia exhibit the highest disease
burdens, predominantly affecting populations in regions with middle, low-middle, and low
Sociodemographic Index (SDI). The study indicates that although the incidence and prevalence
rates are increasing, mortality and DALY rates show a declining trend. The authors utilize
statistical models, including decomposition analysis and health inequality assessments, to
elucidate the findings and forecast future trends, emphasizing the need for innovative healthcare
strategies to address this significant health challenge.
Please review this paper.
user
Title: Global burden of early-onset gallbladder and biliary tract cancer from 1990 to 2021
Version: 2 Date: 28 May 2025
Reviewer's report:
This manuscript assesses the global burden of early-onset gallbladder and biliary tract cancer
(EOGBTC) from 1990 to 2021, particularly among individuals under 50 years old. By utilizing
data from the Global Burden of Disease Study 2021, the authors calculate average annual
percentage changes (AAPCs) and age-standardized rates (ASRs) to analyze trends in prevalence,
incidence, mortality, and disability-adjusted life years (DALYs) associated with EOGBTC.
The findings reveal over 24,555 prevalent cases, 13,611 new cases, and approximately 8,777
deaths due to EOGBTC in 2021. Notably, East Asia and South Asia exhibit the highest disease
burdens, predominantly affecting populations in regions with middle, low-middle, and low
Sociodemographic Index (SDI). The study indicates that although the incidence and prevalence
rates are increasing, mortality and DALY rates show a declining trend. The authors utilize
statistical models, including decomposition analysis and health inequality assessments, to
elucidate the findings and forecast future trends, emphasizing the need for innovative healthcare
strategies to address this significant health challenge.
assistant