Reviewer's report
Title:Association of the -511C/-31T haplotype of IL-1beta and genotypes of
Helicobacter pylori-vacA with chronic gastritis and gastric ulcer
Version: 1Date:30 May 2010
Reviewer: Hossein Dabiri
Reviewer's report:
Major Compulsory Revisions
I – according to the manuscript clarification, it is a case - control study that try to
make an association between IL-1beta polymorphisms and genotypes of
Helicobacter pylori (HP) with chronic gastritis and gastric ulcer, but the control
group is not selected correctly. In the other word for study of role of IL-1beta, the
presence of HP in study group and absence of that in control group is the study
error (HP is confounding factor), however the comparison between chronic
gastritis and gastric ulcer is fine.
II - For appropriate comparison of a factor role in different groups, we have to
normalize and homogenize the groups in order to minimizing the effect of
confounding factors, but in the current study, the three study groups (control,
chronic gastritis, and gastric ulcer) are not homogenous (i.e. Age, education,
family history of gastritis, smoking and etc. are varying in three groups). As a fact
the development of ulcer is multifactorial, therefore how you can explain the
development of gastric ulcer or chronic gastritis is due to different polymorphisms
of IL1-beta not due to differences in age, hygiene condition, smoking habit or…?
On the other words, the authors could not define the exact role of different
polymorphism on clinical outcomes in presence of so many confounding factors
(table 2).
Minor Essential Revisions
I - the manuscript should be revised for English errors
II - giving reference should be rechecked (the first paragraph of page 6)
III - first paragraph of methods section should be written clearly
VI - Result section, paragraph 1: ages should be given by sd (i.e. 26 ± 12)
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Association of the -511C/-31T haplotype of IL-1beta and genotypes of
Helicobacter pylori-vacA with chronic gastritis and gastric ulcer
Version: 1Date:30 May 2010
Reviewer: Hossein Dabiri
Reviewer's report:
Major Compulsory Revisions
I – according to the manuscript clarification, it is a case - control study that try to
make an association between IL-1beta polymorphisms and genotypes of
Helicobacter pylori (HP) with chronic gastritis and gastric ulcer, but the control
group is not selected correctly. In the other word for study of role of IL-1beta, the
presence of HP in study group and absence of that in control group is the study
error (HP is confounding factor), however the comparison between chronic
gastritis and gastric ulcer is fine.
II - For appropriate comparison of a factor role in different groups, we have to
normalize and homogenize the groups in order to minimizing the effect of
confounding factors, but in the current study, the three study groups (control,
chronic gastritis, and gastric ulcer) are not homogenous (i.e. Age, education,
family history of gastritis, smoking and etc. are varying in three groups). As a fact
the development of ulcer is multifactorial, therefore how you can explain the
development of gastric ulcer or chronic gastritis is due to different polymorphisms
of IL1-beta not due to differences in age, hygiene condition, smoking habit or…?
On the other words, the authors could not define the exact role of different
polymorphism on clinical outcomes in presence of so many confounding factors
(table 2).
Minor Essential Revisions
I - the manuscript should be revised for English errors
II - giving reference should be rechecked (the first paragraph of page 6)
III - first paragraph of methods section should be written clearly
VI - Result section, paragraph 1: ages should be given by sd (i.e. 26 ± 12)
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Association of the -511C/-31T haplotype of IL-1beta and genotypes of
Helicobacter pylori-vacA with chronic gastritis and gastric ulcer
Version: 1Date:30 May 2010
Reviewer: Hossein Dabiri
Reviewer's report:
Major Compulsory Revisions
I – according to the manuscript clarification, it is a case - control study that try to
make an association between IL-1beta polymorphisms and genotypes of
Helicobacter pylori (HP) with chronic gastritis and gastric ulcer, but the control
group is not selected correctly. In the other word for study of role of IL-1beta, the
presence of HP in study group and absence of that in control group is the study
error (HP is confounding factor), however the comparison between chronic
gastritis and gastric ulcer is fine.
II - For appropriate comparison of a factor role in different groups, we have to
normalize and homogenize the groups in order to minimizing the effect of
confounding factors, but in the current study, the three study groups (control,
chronic gastritis, and gastric ulcer) are not homogenous (i.e. Age, education,
family history of gastritis, smoking and etc. are varying in three groups). As a fact
the development of ulcer is multifactorial, therefore how you can explain the
development of gastric ulcer or chronic gastritis is due to different polymorphisms
of IL1-beta not due to differences in age, hygiene condition, smoking habit or…?
On the other words, the authors could not define the exact role of different
polymorphism on clinical outcomes in presence of so many confounding factors
(table 2).
Minor Essential Revisions
I - the manuscript should be revised for English errors
II - giving reference should be rechecked (the first paragraph of page 6)
III - first paragraph of methods section should be written clearly
VI - Result section, paragraph 1: ages should be given by sd (i.e. 26 ± 12)
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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