Reviewer's report
Title:Risk of uncomplicated peptic ulcer disease in a cohort of new users of low
dose acetylsalicylic acid for secondary prevention of cardiovascular events
Version:2Date:8 September 2014
Reviewer: Anahita Jalilvand
Reviewer's report:
1. Major or minor essential revisions: none
2. Discretionary revisions:
Although this is mentioned in the discussion, the high prevalence of H pylori
infections in patients who are subsequently diagnosed with PUD does present a
confounding factor. It would be interesting to see how many patients on ASA who
develop PUD are subsequently diagnosed with H. pylori. The goal of this study
was to elucidate the risk factors associated with development of uncomplicated
PUD in patients starting ASA treatment, which it did very clearly. However, the
next question primary care practitioners may face would be how to determine
whether a given patient’s risk for developing PUD is outweighed by the risk of
developing cardiovascular events without ASA therapy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no competing interest in relation to the paper I have reviewed.
Reviewer's report
Title:Risk of uncomplicated peptic ulcer disease in a cohort of new users of low
dose acetylsalicylic acid for secondary prevention of cardiovascular events
Version:2Date:8 September 2014
Reviewer: Anahita Jalilvand
Reviewer's report:
1. Major or minor essential revisions: none
2. Discretionary revisions:
Although this is mentioned in the discussion, the high prevalence of H pylori
infections in patients who are subsequently diagnosed with PUD does present a
confounding factor. It would be interesting to see how many patients on ASA who
develop PUD are subsequently diagnosed with H. pylori. The goal of this study
was to elucidate the risk factors associated with development of uncomplicated
PUD in patients starting ASA treatment, which it did very clearly. However, the
next question primary care practitioners may face would be how to determine
whether a given patient’s risk for developing PUD is outweighed by the risk of
developing cardiovascular events without ASA therapy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no competing interest in relation to the paper I have reviewed.
Please review this paper.
user
Reviewer's report
Title:Risk of uncomplicated peptic ulcer disease in a cohort of new users of low
dose acetylsalicylic acid for secondary prevention of cardiovascular events
Version:2Date:8 September 2014
Reviewer: Anahita Jalilvand
Reviewer's report:
1. Major or minor essential revisions: none
2. Discretionary revisions:
Although this is mentioned in the discussion, the high prevalence of H pylori
infections in patients who are subsequently diagnosed with PUD does present a
confounding factor. It would be interesting to see how many patients on ASA who
develop PUD are subsequently diagnosed with H. pylori. The goal of this study
was to elucidate the risk factors associated with development of uncomplicated
PUD in patients starting ASA treatment, which it did very clearly. However, the
next question primary care practitioners may face would be how to determine
whether a given patient’s risk for developing PUD is outweighed by the risk of
developing cardiovascular events without ASA therapy.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no competing interest in relation to the paper I have reviewed.
assistant