Title: Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study
Version: 4 Date: 28 Jun 2022
Reviewer's report:
The authors revised the manuscript, in response to suggestions, but there are still, a few points
to be considered.
1) In the revised form (in clean copy and in the highlighted copy), persists incidence instead of
prevalence, in various localizations, as for example in the title “Relevant factors for the incidence
of HS” (page 9). That must be corrected.
2) In page 4, lines 83 and 84, is stated “Several clinical studies have shown that elevated SCr
within the normal range (…)”. That could be difficult to understand, an elevated value, “in the
normal range”. It’s suggested to clearer that.
3) In the same page (line 88), is stated that “SCr (serum creatinine) is found in meat”. It’s
advisable to reformulate that affirmation, as serum creatinine comes from muscle, if that was
what authors meant.
4) Following that sentence, there is an explanation that results difficult to understand: how
inosine ingestion and the following increase in uric acid production, can explain the association
of elevated levels of SCr, and HS. As creatinine is synthetized from amino acids (and not from
a purine nucleoside). That issue, should be clarified.
5) MAFLD currently stands for Metabolic Associated Fatty Liver Disease, and not metabolism-
related fatty liver disease (page 11, line 238).
6) In page 12, line 246, the acronym VCTE, should be detailed and listed in abbreviations list.
Title: Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study
Version: 4 Date: 28 Jun 2022
Reviewer's report:
The authors revised the manuscript, in response to suggestions, but there are still, a few points
to be considered.
1) In the revised form (in clean copy and in the highlighted copy), persists incidence instead of
prevalence, in various localizations, as for example in the title “Relevant factors for the incidence
of HS” (page 9). That must be corrected.
2) In page 4, lines 83 and 84, is stated “Several clinical studies have shown that elevated SCr
within the normal range (…)”. That could be difficult to understand, an elevated value, “in the
normal range”. It’s suggested to clearer that.
3) In the same page (line 88), is stated that “SCr (serum creatinine) is found in meat”. It’s
advisable to reformulate that affirmation, as serum creatinine comes from muscle, if that was
what authors meant.
4) Following that sentence, there is an explanation that results difficult to understand: how
inosine ingestion and the following increase in uric acid production, can explain the association
of elevated levels of SCr, and HS. As creatinine is synthetized from amino acids (and not from
a purine nucleoside). That issue, should be clarified.
5) MAFLD currently stands for Metabolic Associated Fatty Liver Disease, and not metabolism-
related fatty liver disease (page 11, line 238).
6) In page 12, line 246, the acronym VCTE, should be detailed and listed in abbreviations list.
Please review this paper.
user
Title: Association of serum creatinine with hepatic steatosis and fibrosis: a cross-sectional study
Version: 4 Date: 28 Jun 2022
Reviewer's report:
The authors revised the manuscript, in response to suggestions, but there are still, a few points
to be considered.
1) In the revised form (in clean copy and in the highlighted copy), persists incidence instead of
prevalence, in various localizations, as for example in the title “Relevant factors for the incidence
of HS” (page 9). That must be corrected.
2) In page 4, lines 83 and 84, is stated “Several clinical studies have shown that elevated SCr
within the normal range (…)”. That could be difficult to understand, an elevated value, “in the
normal range”. It’s suggested to clearer that.
3) In the same page (line 88), is stated that “SCr (serum creatinine) is found in meat”. It’s
advisable to reformulate that affirmation, as serum creatinine comes from muscle, if that was
what authors meant.
4) Following that sentence, there is an explanation that results difficult to understand: how
inosine ingestion and the following increase in uric acid production, can explain the association
of elevated levels of SCr, and HS. As creatinine is synthetized from amino acids (and not from
a purine nucleoside). That issue, should be clarified.
5) MAFLD currently stands for Metabolic Associated Fatty Liver Disease, and not metabolism-
related fatty liver disease (page 11, line 238).
6) In page 12, line 246, the acronym VCTE, should be detailed and listed in abbreviations list.
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