Title: Efficacy and safety of Endoscopic nasobiliary drainage versus percutaneous transhepatic
cholangial drainage in the treatment of advanced hilar cholangiocarcinoma: a systematic review
and meta-analysis
Version: 8 Date: 28 May 2024
Reviewer:  Yang Liu
Reviewer's report:
1. Is the author not familiar with PTCD and ENBD? The guide wire of PTCD does not pass
through the tumor, while the guide wire of ENBD needs to pass through the tumor. The author's
description in 233-241 is very confusing and needs to be revised.
2. Why does ENBD expel bile from the body and enter the external collection bag  compared
to PTCD, it may reduce the incidence and severity of postoperative electrolyte imbalance and
digestive function damage in patients? PTCD also has an external collection bag, and the method
of handling bile can be the same as ENBD, such as collecting bile and taking it orally.
Title: Efficacy and safety of Endoscopic nasobiliary drainage versus percutaneous transhepatic
cholangial drainage in the treatment of advanced hilar cholangiocarcinoma: a systematic review
and meta-analysis
Version: 8 Date: 28 May 2024
Reviewer:  Yang Liu
Reviewer's report:
1. Is the author not familiar with PTCD and ENBD? The guide wire of PTCD does not pass
through the tumor, while the guide wire of ENBD needs to pass through the tumor. The author's
description in 233-241 is very confusing and needs to be revised.
2. Why does ENBD expel bile from the body and enter the external collection bag  compared
to PTCD, it may reduce the incidence and severity of postoperative electrolyte imbalance and
digestive function damage in patients? PTCD also has an external collection bag, and the method
of handling bile can be the same as ENBD, such as collecting bile and taking it orally.
Please review this paper.
user
Title: Efficacy and safety of Endoscopic nasobiliary drainage versus percutaneous transhepatic
cholangial drainage in the treatment of advanced hilar cholangiocarcinoma: a systematic review
and meta-analysis
Version: 8 Date: 28 May 2024
Reviewer:  Yang Liu
Reviewer's report:
1. Is the author not familiar with PTCD and ENBD? The guide wire of PTCD does not pass
through the tumor, while the guide wire of ENBD needs to pass through the tumor. The author's
description in 233-241 is very confusing and needs to be revised.
2. Why does ENBD expel bile from the body and enter the external collection bag  compared
to PTCD, it may reduce the incidence and severity of postoperative electrolyte imbalance and
digestive function damage in patients? PTCD also has an external collection bag, and the method
of handling bile can be the same as ENBD, such as collecting bile and taking it orally.
assistant