Title: Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in
Chinese Han adults: a secondary analysis based on a case-control study
Version: 0 Date: 22 Sep 2021
Reviewer's report:
Review of “Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver
disease in Chinese Han adults: a secondary analysis based on a case-control study” (74a6515c-
bb15-4040-abc4-4dafca935660)
This study investigated the association between total polyunsaturated fatty acid intake and the
presence of non-alcoholic fatty liver disease using the data of previously published data. This
study is potentially interesting; however, several problems to be solved.
1. This case-control study is not evaluating the causal relationship between total polyunsaturated
fatty acid intake and incident NAFLD.
2. This study used data from the previous study, and the authors of this study might not know
the detail. However, it is unclear from what population the 1,068 people were selected. This is
a crucial problem.
3. Duplicate description. “NAFLD patients is based on the "Guidelines for the Diagnosis and
Treatment of Non-Alcoholic Fatty Liver Disease: 2010 Update" [21]. Ultrasound examinations
are implemented by experienced ultrasonographists who were unaware of laboratory and clinical
data.”
4. Please add the data of OR of covariates.
Title: Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in
Chinese Han adults: a secondary analysis based on a case-control study
Version: 0 Date: 22 Sep 2021
Reviewer's report:
Review of “Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver
disease in Chinese Han adults: a secondary analysis based on a case-control study” (74a6515c-
bb15-4040-abc4-4dafca935660)
This study investigated the association between total polyunsaturated fatty acid intake and the
presence of non-alcoholic fatty liver disease using the data of previously published data. This
study is potentially interesting; however, several problems to be solved.
1. This case-control study is not evaluating the causal relationship between total polyunsaturated
fatty acid intake and incident NAFLD.
2. This study used data from the previous study, and the authors of this study might not know
the detail. However, it is unclear from what population the 1,068 people were selected. This is
a crucial problem.
3. Duplicate description. “NAFLD patients is based on the "Guidelines for the Diagnosis and
Treatment of Non-Alcoholic Fatty Liver Disease: 2010 Update" [21]. Ultrasound examinations
are implemented by experienced ultrasonographists who were unaware of laboratory and clinical
data.”
4. Please add the data of OR of covariates.
Please review this paper.
user
Title: Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver disease in
Chinese Han adults: a secondary analysis based on a case-control study
Version: 0 Date: 22 Sep 2021
Reviewer's report:
Review of “Total polyunsaturated fatty acid intake and the risk of non-alcoholic fatty liver
disease in Chinese Han adults: a secondary analysis based on a case-control study” (74a6515c-
bb15-4040-abc4-4dafca935660)
This study investigated the association between total polyunsaturated fatty acid intake and the
presence of non-alcoholic fatty liver disease using the data of previously published data. This
study is potentially interesting; however, several problems to be solved.
1. This case-control study is not evaluating the causal relationship between total polyunsaturated
fatty acid intake and incident NAFLD.
2. This study used data from the previous study, and the authors of this study might not know
the detail. However, it is unclear from what population the 1,068 people were selected. This is
a crucial problem.
3. Duplicate description. “NAFLD patients is based on the "Guidelines for the Diagnosis and
Treatment of Non-Alcoholic Fatty Liver Disease: 2010 Update" [21]. Ultrasound examinations
are implemented by experienced ultrasonographists who were unaware of laboratory and clinical
data.”
4. Please add the data of OR of covariates.
assistant