Reviewer's report
Title:Overexpression of SLC38A1 is associated with poorer prognosis in
Chinese patients with gastric cancer
Version: 1Date:25 July 2013
Reviewer: Sumiya Ishigami
Reviewer's report:
The author demonstrated SLC38A1 was overexpressed in gastric cancer tissues
and most likely contributes to tumor progression as independent prognostic
marker for the first time.
The patients’ number is large (more than 1000!) and the results of this study are
interesting and original. It seems to be suitable for acceptance in this journal;
however, some critical points could not be ignored.
Please resubmit after removing stage IV gastric cancer patients.
Major points
1) Overall survival in these patients is extremely poor even though 40% of the
patients were stage I or II. The author did not mention about the operation
manner and R0 surgery or not. 1074 patients may receive non-curative surgery.
Please add the information of surgery such as the tumor location, the degree of
lymph node dissection, operation manner (total, distal and proximal
gastrectomy), and anticancer treatment before and after surgery.
2) Prognostic significance cannot be evaluated using the patients receiving R1 or
R2 patients. Please remove stage IV gastric cancer patients in this study.
3) Table 1 is missing.
4) Their three previous studies using gene chip analysis really suggested an
elevated SLC38A1 mRNA expression in gastric cancer?
Reviewer's report
Title:Overexpression of SLC38A1 is associated with poorer prognosis in
Chinese patients with gastric cancer
Version: 1Date:25 July 2013
Reviewer: Sumiya Ishigami
Reviewer's report:
The author demonstrated SLC38A1 was overexpressed in gastric cancer tissues
and most likely contributes to tumor progression as independent prognostic
marker for the first time.
The patients’ number is large (more than 1000!) and the results of this study are
interesting and original. It seems to be suitable for acceptance in this journal;
however, some critical points could not be ignored.
Please resubmit after removing stage IV gastric cancer patients.
Major points
1) Overall survival in these patients is extremely poor even though 40% of the
patients were stage I or II. The author did not mention about the operation
manner and R0 surgery or not. 1074 patients may receive non-curative surgery.
Please add the information of surgery such as the tumor location, the degree of
lymph node dissection, operation manner (total, distal and proximal
gastrectomy), and anticancer treatment before and after surgery.
2) Prognostic significance cannot be evaluated using the patients receiving R1 or
R2 patients. Please remove stage IV gastric cancer patients in this study.
3) Table 1 is missing.
4) Their three previous studies using gene chip analysis really suggested an
elevated SLC38A1 mRNA expression in gastric cancer?
Please review this paper.
user
Reviewer's report
Title:Overexpression of SLC38A1 is associated with poorer prognosis in
Chinese patients with gastric cancer
Version: 1Date:25 July 2013
Reviewer: Sumiya Ishigami
Reviewer's report:
The author demonstrated SLC38A1 was overexpressed in gastric cancer tissues
and most likely contributes to tumor progression as independent prognostic
marker for the first time.
The patients’ number is large (more than 1000!) and the results of this study are
interesting and original. It seems to be suitable for acceptance in this journal;
however, some critical points could not be ignored.
Please resubmit after removing stage IV gastric cancer patients.
Major points
1) Overall survival in these patients is extremely poor even though 40% of the
patients were stage I or II. The author did not mention about the operation
manner and R0 surgery or not. 1074 patients may receive non-curative surgery.
Please add the information of surgery such as the tumor location, the degree of
lymph node dissection, operation manner (total, distal and proximal
gastrectomy), and anticancer treatment before and after surgery.
2) Prognostic significance cannot be evaluated using the patients receiving R1 or
R2 patients. Please remove stage IV gastric cancer patients in this study.
3) Table 1 is missing.
4) Their three previous studies using gene chip analysis really suggested an
elevated SLC38A1 mRNA expression in gastric cancer?
assistant