Reviewer's report
Title:The earliest trough concentration predicts the dose of tacrolimus required
for remission induction therapy in ulcerative colitis patients
Version:2Date:16 January 2015
Reviewer: Xavier Roblin
Reviewer's report:
Minor essential revisions
The authors defined clinical remission , response and failure but they don't
explain if stop of steroids is included in their definitions : clarification
Some patients are also with an immunomodulator: what drug ? are these drugs
continue? is frequent to be under combo therapy in asia?
Report an easy algorithm based on levels at D3 to suggest modifications of dose
in one figure
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interest
Reviewer's report
Title:The earliest trough concentration predicts the dose of tacrolimus required
for remission induction therapy in ulcerative colitis patients
Version:2Date:16 January 2015
Reviewer: Xavier Roblin
Reviewer's report:
Minor essential revisions
The authors defined clinical remission , response and failure but they don't
explain if stop of steroids is included in their definitions : clarification
Some patients are also with an immunomodulator: what drug ? are these drugs
continue? is frequent to be under combo therapy in asia?
Report an easy algorithm based on levels at D3 to suggest modifications of dose
in one figure
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interest
Please review this paper.
user
Reviewer's report
Title:The earliest trough concentration predicts the dose of tacrolimus required
for remission induction therapy in ulcerative colitis patients
Version:2Date:16 January 2015
Reviewer: Xavier Roblin
Reviewer's report:
Minor essential revisions
The authors defined clinical remission , response and failure but they don't
explain if stop of steroids is included in their definitions : clarification
Some patients are also with an immunomodulator: what drug ? are these drugs
continue? is frequent to be under combo therapy in asia?
Report an easy algorithm based on levels at D3 to suggest modifications of dose
in one figure
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interest
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