Title: The predictive value of CD4, CD8, and C - reactive protein in the prognosis
of schistosomal and non-schistosomal colorectal cancer
Version: 0 Date: 23 Feb 2023
Reviewer's report:
he authors, entitled "The predictive value of CD4, CD8, and C-reactive protein in the prognosis
of schistosomal and non-schistosomal colorectal cancer" aimed to provide a possible predictive
system to evaluate outcomes for patients with schistosomiasis. The study was well performed
with the right methodology. Please find points of criticism below.
1. There are no clear scientific statements and discussions about novelty of this research, because
TILs, mainly CD4 and CD8 T cells have been extensively described in anti-tumor immunity and
knowledge of CD4 and CD8 T lymphocytes' interplay in mediating the control of tumor growth
exists. It seemed that there was no novelty and meaningless for the authors to adopt the complex
procedure in the prognosis of schistosomal and non-schistosomal colorectal cancer. Therefore,
it is better for the authors to investigate the diagnosis effect by other markers combined with the
image detection or biopsy among the colorectal cancers.
2. As known to all, iCD4 and sCD8 is widely used as a surveillance factor for CRC. Combined
with B ultra-sound or CT image examination, it was convenient and efficient for the diagnosis
of CRC. For schistosomal and non-schistosomal CRC, other markers combined with the image
detection or biopsy could help for the independent prognostic factor for NSCRC patients and
for SCRC patients.
3. There are some misspellings throughout texts and need to be corrected.
Title: The predictive value of CD4, CD8, and C - reactive protein in the prognosis
of schistosomal and non-schistosomal colorectal cancer
Version: 0 Date: 23 Feb 2023
Reviewer's report:
he authors, entitled "The predictive value of CD4, CD8, and C-reactive protein in the prognosis
of schistosomal and non-schistosomal colorectal cancer" aimed to provide a possible predictive
system to evaluate outcomes for patients with schistosomiasis. The study was well performed
with the right methodology. Please find points of criticism below.
1. There are no clear scientific statements and discussions about novelty of this research, because
TILs, mainly CD4 and CD8 T cells have been extensively described in anti-tumor immunity and
knowledge of CD4 and CD8 T lymphocytes' interplay in mediating the control of tumor growth
exists. It seemed that there was no novelty and meaningless for the authors to adopt the complex
procedure in the prognosis of schistosomal and non-schistosomal colorectal cancer. Therefore,
it is better for the authors to investigate the diagnosis effect by other markers combined with the
image detection or biopsy among the colorectal cancers.
2. As known to all, iCD4 and sCD8 is widely used as a surveillance factor for CRC. Combined
with B ultra-sound or CT image examination, it was convenient and efficient for the diagnosis
of CRC. For schistosomal and non-schistosomal CRC, other markers combined with the image
detection or biopsy could help for the independent prognostic factor for NSCRC patients and
for SCRC patients.
3. There are some misspellings throughout texts and need to be corrected.
Please review this paper.
user
Title: The predictive value of CD4, CD8, and C - reactive protein in the prognosis
of schistosomal and non-schistosomal colorectal cancer
Version: 0 Date: 23 Feb 2023
Reviewer's report:
he authors, entitled "The predictive value of CD4, CD8, and C-reactive protein in the prognosis
of schistosomal and non-schistosomal colorectal cancer" aimed to provide a possible predictive
system to evaluate outcomes for patients with schistosomiasis. The study was well performed
with the right methodology. Please find points of criticism below.
1. There are no clear scientific statements and discussions about novelty of this research, because
TILs, mainly CD4 and CD8 T cells have been extensively described in anti-tumor immunity and
knowledge of CD4 and CD8 T lymphocytes' interplay in mediating the control of tumor growth
exists. It seemed that there was no novelty and meaningless for the authors to adopt the complex
procedure in the prognosis of schistosomal and non-schistosomal colorectal cancer. Therefore,
it is better for the authors to investigate the diagnosis effect by other markers combined with the
image detection or biopsy among the colorectal cancers.
2. As known to all, iCD4 and sCD8 is widely used as a surveillance factor for CRC. Combined
with B ultra-sound or CT image examination, it was convenient and efficient for the diagnosis
of CRC. For schistosomal and non-schistosomal CRC, other markers combined with the image
detection or biopsy could help for the independent prognostic factor for NSCRC patients and
for SCRC patients.
3. There are some misspellings throughout texts and need to be corrected.
assistant