Reviewer's report
Title:Mutational Profiles of Different Macroscopic Subtypes of Colorectal
Adenoma Reveal Distinct Pathogenetic Roles for KRAS, BRAF and PIK3CA
Version:3Date:10 November 2014
Reviewer: Takahisa Matsuda
Reviewer's report:
This is the single center prospective study to elucidate the frequency of KRAS
mutation and BRAF mutation in polypoid, flat and depressed colorectal
neoplasms and compare these morphological counterparts each other. The
authors hold a body of data which is valuable. A few changes and additional
description would improve the overall message. I have only a few comments.
1. The authors should quote this article. Kaji E, Kato J, Suzuki H, et al, Analysis
of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the
colorectum. J Gastroenterol Hepatol 2011.
2. I suppose that the number of subjects is limited, therefore, it seems to be
difficult to discuss with regard to the frequency of KRAS mutation based on the
lesions’ location. This is a limitation of this prospective study. The authors should
discuss about this issue or describe as one of limitation in the discussion section.
3. Table 2: Please revise the term from “RIK3CA” to “PIK3CA”.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
Reviewer's report
Title:Mutational Profiles of Different Macroscopic Subtypes of Colorectal
Adenoma Reveal Distinct Pathogenetic Roles for KRAS, BRAF and PIK3CA
Version:3Date:10 November 2014
Reviewer: Takahisa Matsuda
Reviewer's report:
This is the single center prospective study to elucidate the frequency of KRAS
mutation and BRAF mutation in polypoid, flat and depressed colorectal
neoplasms and compare these morphological counterparts each other. The
authors hold a body of data which is valuable. A few changes and additional
description would improve the overall message. I have only a few comments.
1. The authors should quote this article. Kaji E, Kato J, Suzuki H, et al, Analysis
of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the
colorectum. J Gastroenterol Hepatol 2011.
2. I suppose that the number of subjects is limited, therefore, it seems to be
difficult to discuss with regard to the frequency of KRAS mutation based on the
lesions’ location. This is a limitation of this prospective study. The authors should
discuss about this issue or describe as one of limitation in the discussion section.
3. Table 2: Please revise the term from “RIK3CA” to “PIK3CA”.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
Please review this paper.
user
Reviewer's report
Title:Mutational Profiles of Different Macroscopic Subtypes of Colorectal
Adenoma Reveal Distinct Pathogenetic Roles for KRAS, BRAF and PIK3CA
Version:3Date:10 November 2014
Reviewer: Takahisa Matsuda
Reviewer's report:
This is the single center prospective study to elucidate the frequency of KRAS
mutation and BRAF mutation in polypoid, flat and depressed colorectal
neoplasms and compare these morphological counterparts each other. The
authors hold a body of data which is valuable. A few changes and additional
description would improve the overall message. I have only a few comments.
1. The authors should quote this article. Kaji E, Kato J, Suzuki H, et al, Analysis
of K-ras, BRAF, and PIK3CA mutations in laterally-spreading tumors of the
colorectum. J Gastroenterol Hepatol 2011.
2. I suppose that the number of subjects is limited, therefore, it seems to be
difficult to discuss with regard to the frequency of KRAS mutation based on the
lesions’ location. This is a limitation of this prospective study. The authors should
discuss about this issue or describe as one of limitation in the discussion section.
3. Table 2: Please revise the term from “RIK3CA” to “PIK3CA”.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
None
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