Title: Comprehensive analysis of m6A regulators associated with immune infiltration in
Hepatitis B virus-related hepatocellular carcinoma
Version: 2 Date: 17 Apr 2023
Reviewer's report:
This study is well-designed and the manuscript is well-written, but there are several concerns
still need to be solved before further proceeding.
1. “HBV” should be omitted in the title.
2. There are so many researches concerning the association between m6a regulators and HCC.
What is the difference between your research and before studies.
3. Authors performed the study using TCGA and GSE14520 dataset, but not both of them are
HBV-related HCC patients. Therefore, if it is appropriate to naming this title?
4. Why did not authors conduct both in vitro and in vivo experiments to further validate their
conclusions and explore specific mechanisms?
5. Authors ought to add more discussion content regarding present findings and previous reports
in the Discussion part.
6. In the Availability of data and materials part#there should be “hepatocellular carcinoma”
rather than “gastric cancer”. Also, authors should add the availability of GEO database.
Title: Comprehensive analysis of m6A regulators associated with immune infiltration in
Hepatitis B virus-related hepatocellular carcinoma
Version: 2 Date: 17 Apr 2023
Reviewer's report:
This study is well-designed and the manuscript is well-written, but there are several concerns
still need to be solved before further proceeding.
1. “HBV” should be omitted in the title.
2. There are so many researches concerning the association between m6a regulators and HCC.
What is the difference between your research and before studies.
3. Authors performed the study using TCGA and GSE14520 dataset, but not both of them are
HBV-related HCC patients. Therefore, if it is appropriate to naming this title?
4. Why did not authors conduct both in vitro and in vivo experiments to further validate their
conclusions and explore specific mechanisms?
5. Authors ought to add more discussion content regarding present findings and previous reports
in the Discussion part.
6. In the Availability of data and materials part#there should be “hepatocellular carcinoma”
rather than “gastric cancer”. Also, authors should add the availability of GEO database.
Please review this paper.
user
Title: Comprehensive analysis of m6A regulators associated with immune infiltration in
Hepatitis B virus-related hepatocellular carcinoma
Version: 2 Date: 17 Apr 2023
Reviewer's report:
This study is well-designed and the manuscript is well-written, but there are several concerns
still need to be solved before further proceeding.
1. “HBV” should be omitted in the title.
2. There are so many researches concerning the association between m6a regulators and HCC.
What is the difference between your research and before studies.
3. Authors performed the study using TCGA and GSE14520 dataset, but not both of them are
HBV-related HCC patients. Therefore, if it is appropriate to naming this title?
4. Why did not authors conduct both in vitro and in vivo experiments to further validate their
conclusions and explore specific mechanisms?
5. Authors ought to add more discussion content regarding present findings and previous reports
in the Discussion part.
6. In the Availability of data and materials part#there should be “hepatocellular carcinoma”
rather than “gastric cancer”. Also, authors should add the availability of GEO database.
assistant