Title: Clinicopathological significance of HSP70 expression in gastric cancer: a systematic
review and meta-analysis
Version: 0 Date: 14 Sep 2021
Reviewer's report:
Wang et al included 9 studies with 1,307 gastric cancer patients to explore clinicopathological
significance of HSP70 expression in gastric cancer using meta-analysis. They found that HSP70
expression was significantly correlated with higher differentiation degrees, intestinal gastric
cancer, and lymphovascular invasion but no significant correlation between HSP70 expression
and overall survival of gastric cancer patients. In generally, this meta-analysis was firstly
reported in current database, thus it has certain novelty, but there are some major concerns need
to address.
1. In the method part, the authors did not mention the time when the search on the database
was began.
2. The authors are from China, but they only search the English database, why they don’t search
Chinese databases to enlarger the number of included study.
Title: Clinicopathological significance of HSP70 expression in gastric cancer: a systematic
review and meta-analysis
Version: 0 Date: 14 Sep 2021
Reviewer's report:
Wang et al included 9 studies with 1,307 gastric cancer patients to explore clinicopathological
significance of HSP70 expression in gastric cancer using meta-analysis. They found that HSP70
expression was significantly correlated with higher differentiation degrees, intestinal gastric
cancer, and lymphovascular invasion but no significant correlation between HSP70 expression
and overall survival of gastric cancer patients. In generally, this meta-analysis was firstly
reported in current database, thus it has certain novelty, but there are some major concerns need
to address.
1. In the method part, the authors did not mention the time when the search on the database
was began.
2. The authors are from China, but they only search the English database, why they don’t search
Chinese databases to enlarger the number of included study.
Please review this paper.
user
Title: Clinicopathological significance of HSP70 expression in gastric cancer: a systematic
review and meta-analysis
Version: 0 Date: 14 Sep 2021
Reviewer's report:
Wang et al included 9 studies with 1,307 gastric cancer patients to explore clinicopathological
significance of HSP70 expression in gastric cancer using meta-analysis. They found that HSP70
expression was significantly correlated with higher differentiation degrees, intestinal gastric
cancer, and lymphovascular invasion but no significant correlation between HSP70 expression
and overall survival of gastric cancer patients. In generally, this meta-analysis was firstly
reported in current database, thus it has certain novelty, but there are some major concerns need
to address.
1. In the method part, the authors did not mention the time when the search on the database
was began.
2. The authors are from China, but they only search the English database, why they don’t search
Chinese databases to enlarger the number of included study.
assistant