Title: Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in
patients with chronic constipation
Version: 0 Date: 01 Aug 2021
Reviewer's report:
This study is a single-arm prospective study to investigate the efficacy and safety of macrogol
4000 intake the night before colonoscopy.
I think the main problem is the study design.
1. The main hypothesis of this study is to investigate the efficacy of the additional dose of
macrogol 4000 to PEG in patients with chronic constipation as bowel preparation. However,
single-arm trials are not generally used as confirmation of efficacy. There was no control group
for elucidating the efficacy of the macrogol 4000.
2. The ADR and PDR were remarkably higher than in other studies. Is there any selection bias
in the study?
3. Furthermore, in this study, macrogol 4000 is the additional dose to PEG. To compare the
tolerability of macrogol 4000 and PEG is not appropriate.
4. In figure 2, the BBPS was best at the transverse colon than the right-sided and left-sided colon.
The authors should describe some reasons for the results.
Title: Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in
patients with chronic constipation
Version: 0 Date: 01 Aug 2021
Reviewer's report:
This study is a single-arm prospective study to investigate the efficacy and safety of macrogol
4000 intake the night before colonoscopy.
I think the main problem is the study design.
1. The main hypothesis of this study is to investigate the efficacy of the additional dose of
macrogol 4000 to PEG in patients with chronic constipation as bowel preparation. However,
single-arm trials are not generally used as confirmation of efficacy. There was no control group
for elucidating the efficacy of the macrogol 4000.
2. The ADR and PDR were remarkably higher than in other studies. Is there any selection bias
in the study?
3. Furthermore, in this study, macrogol 4000 is the additional dose to PEG. To compare the
tolerability of macrogol 4000 and PEG is not appropriate.
4. In figure 2, the BBPS was best at the transverse colon than the right-sided and left-sided colon.
The authors should describe some reasons for the results.
Please review this paper.
user
Title: Efficacy of macrogol 4000 plus electrolytes in bowel preparation for colonoscopy in
patients with chronic constipation
Version: 0 Date: 01 Aug 2021
Reviewer's report:
This study is a single-arm prospective study to investigate the efficacy and safety of macrogol
4000 intake the night before colonoscopy.
I think the main problem is the study design.
1. The main hypothesis of this study is to investigate the efficacy of the additional dose of
macrogol 4000 to PEG in patients with chronic constipation as bowel preparation. However,
single-arm trials are not generally used as confirmation of efficacy. There was no control group
for elucidating the efficacy of the macrogol 4000.
2. The ADR and PDR were remarkably higher than in other studies. Is there any selection bias
in the study?
3. Furthermore, in this study, macrogol 4000 is the additional dose to PEG. To compare the
tolerability of macrogol 4000 and PEG is not appropriate.
4. In figure 2, the BBPS was best at the transverse colon than the right-sided and left-sided colon.
The authors should describe some reasons for the results.
assistant