Reviewer's report
Title:Concurrent association of inflammatory polymyositis and Crohn's ileo-colitis
in a male: A case report of a rare association and review of literature
Version:3Date:1 November 2013
Reviewer: Antonio Tursi
Reviewer's report:
This interesting case reports describes a rare association of polymyositis and
Crohn’s disease (CD), successfully managed after treatment with
immunosuppressors and steroids.
The manuscript is worthy of publication, However, some issues have to be
addressed:
Major points
1. Dosages of drugs used have in managing this patient must be described.
2. Which probiotic strain was provided? And for how many time?
2. For how many time drugs used were provided? In other words, for how many
time mesalazine were provided? And prednisolone? And azathioprine?
3. Some pathogenetic hypothesis about this rare association must be provided in
discussion. For example, Cuoco et al. found that TNF-#, sphingosine and
lipopolysaccaride were increased (p<0.01), whilst muscular fibres size was
reduced (p<0.01), with shift of Myosin Heavy Chains from the slow to the fast
type, in CD patients with active, steroid-free disease (Int J Cardiol 2008;127:
219-27). This paper and its immuno-histochemical analyses is an interesting
point for discussion of this case, and must to be cited and commented.
Minor points
There are several spelling errors (e.g. “polymiocitis” istead of “polymyositis”).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I don't have any conflict of interest.
Reviewer's report
Title:Concurrent association of inflammatory polymyositis and Crohn's ileo-colitis
in a male: A case report of a rare association and review of literature
Version:3Date:1 November 2013
Reviewer: Antonio Tursi
Reviewer's report:
This interesting case reports describes a rare association of polymyositis and
Crohn’s disease (CD), successfully managed after treatment with
immunosuppressors and steroids.
The manuscript is worthy of publication, However, some issues have to be
addressed:
Major points
1. Dosages of drugs used have in managing this patient must be described.
2. Which probiotic strain was provided? And for how many time?
2. For how many time drugs used were provided? In other words, for how many
time mesalazine were provided? And prednisolone? And azathioprine?
3. Some pathogenetic hypothesis about this rare association must be provided in
discussion. For example, Cuoco et al. found that TNF-#, sphingosine and
lipopolysaccaride were increased (p<0.01), whilst muscular fibres size was
reduced (p<0.01), with shift of Myosin Heavy Chains from the slow to the fast
type, in CD patients with active, steroid-free disease (Int J Cardiol 2008;127:
219-27). This paper and its immuno-histochemical analyses is an interesting
point for discussion of this case, and must to be cited and commented.
Minor points
There are several spelling errors (e.g. “polymiocitis” istead of “polymyositis”).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I don't have any conflict of interest.
Please review this paper.
user
Reviewer's report
Title:Concurrent association of inflammatory polymyositis and Crohn's ileo-colitis
in a male: A case report of a rare association and review of literature
Version:3Date:1 November 2013
Reviewer: Antonio Tursi
Reviewer's report:
This interesting case reports describes a rare association of polymyositis and
Crohn’s disease (CD), successfully managed after treatment with
immunosuppressors and steroids.
The manuscript is worthy of publication, However, some issues have to be
addressed:
Major points
1. Dosages of drugs used have in managing this patient must be described.
2. Which probiotic strain was provided? And for how many time?
2. For how many time drugs used were provided? In other words, for how many
time mesalazine were provided? And prednisolone? And azathioprine?
3. Some pathogenetic hypothesis about this rare association must be provided in
discussion. For example, Cuoco et al. found that TNF-#, sphingosine and
lipopolysaccaride were increased (p<0.01), whilst muscular fibres size was
reduced (p<0.01), with shift of Myosin Heavy Chains from the slow to the fast
type, in CD patients with active, steroid-free disease (Int J Cardiol 2008;127:
219-27). This paper and its immuno-histochemical analyses is an interesting
point for discussion of this case, and must to be cited and commented.
Minor points
There are several spelling errors (e.g. “polymiocitis” istead of “polymyositis”).
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I don't have any conflict of interest.
assistant