Reviewer's report
Title:Outcomes and factors influencing the survival in cases with spontaneous
rupture of hepatocellular carcinoma: a multicenter study
Version: 2Date:2 January 2009
Reviewer: Spiros Delis
Reviewer's report:
This paper puts into context the previously exaggerated claims for spontaneous
rupture of HCC.
1. The manuscript and particular the discusion needs to be shortened
2.The manuscript i interesting due to the fairly large cohort of ruptured HCC
although the comparison groups are not similar regarding liver function.ConT
gr4oup seems to have less hepatic reserve compared to TAE group.
3. Although all patients died from re-rupture or liver failure in the ConT group
there is no reported effort for rescue TAE in this group of patients who developed
rebleeding.What was the reason?
4. There was also not reported any effort for liver resection in patients who
eventually survived by TAE .How many patients developed recurrence post TAE
and how they were treated during the follow up period before they finally died?
Do you use other strategies :such as RF ablation or repeated TAE
Reviewer's report
Title:Outcomes and factors influencing the survival in cases with spontaneous
rupture of hepatocellular carcinoma: a multicenter study
Version: 2Date:2 January 2009
Reviewer: Spiros Delis
Reviewer's report:
This paper puts into context the previously exaggerated claims for spontaneous
rupture of HCC.
1. The manuscript and particular the discusion needs to be shortened
2.The manuscript i interesting due to the fairly large cohort of ruptured HCC
although the comparison groups are not similar regarding liver function.ConT
gr4oup seems to have less hepatic reserve compared to TAE group.
3. Although all patients died from re-rupture or liver failure in the ConT group
there is no reported effort for rescue TAE in this group of patients who developed
rebleeding.What was the reason?
4. There was also not reported any effort for liver resection in patients who
eventually survived by TAE .How many patients developed recurrence post TAE
and how they were treated during the follow up period before they finally died?
Do you use other strategies :such as RF ablation or repeated TAE
Please review this paper.
user
Reviewer's report
Title:Outcomes and factors influencing the survival in cases with spontaneous
rupture of hepatocellular carcinoma: a multicenter study
Version: 2Date:2 January 2009
Reviewer: Spiros Delis
Reviewer's report:
This paper puts into context the previously exaggerated claims for spontaneous
rupture of HCC.
1. The manuscript and particular the discusion needs to be shortened
2.The manuscript i interesting due to the fairly large cohort of ruptured HCC
although the comparison groups are not similar regarding liver function.ConT
gr4oup seems to have less hepatic reserve compared to TAE group.
3. Although all patients died from re-rupture or liver failure in the ConT group
there is no reported effort for rescue TAE in this group of patients who developed
rebleeding.What was the reason?
4. There was also not reported any effort for liver resection in patients who
eventually survived by TAE .How many patients developed recurrence post TAE
and how they were treated during the follow up period before they finally died?
Do you use other strategies :such as RF ablation or repeated TAE
assistant