Title: Construction of a novel necroptosis-related lncRNA signature for prognosis prediction
in esophageal cancer
Version: 1 Date: 03 Jun 2022
Reviewer:  Weidong Ni
Reviewer's report:
It's a very interesting topic. Esophageal cancer is a significant malignant type of cancer with a
high mortality rate. In this study, the authors showed 6 necroptosis-related lncRNAs as a reliable
prognostic signature for survival, which offered novel potential prognostic markers for patients
with esophagus cancer. However, there are still some issues to be clarified before publication.
Major Comments:
1. In Figs 1, 6C, and 8, most font sizes utilized are too small to be legible. Please redesign to
enhance legibility.
2. Please add some comments for necroptosis-related lncRNA based signatures to predict
prognoses of other gastrointestinal tumors in the discussion section.
3. The conclusions are not rigorous and the current data only support the predicted prognosis,
without any data to support the prospect of treatment.
4. Line 206 in the article, why AMD12-AS1 was not shown in Fig 4D? And provide the titles
of the train, test, and entire set in Fig 4B-D?
5. It seems that the images in Fig.2 are not supporting to draw any conclusion, especially in
Fig 2B and 2C. Providing a cluster analysis of differential genes in Fig 2A may be beneficial to
explore the pattern of lncRNA expression in tumor prognosis.
6. The language of English was poor, and please modified.
Minor Comments:
1. The X- and Y-axis titles of many graphs are omitted, which makes it difficult to understand,
please present.
2. Please avoid the use of generic terms such as Line 270 in the article the word “good” and
replace it with more specific language.
3. There is a mistake in Line 263 in the article “Further more”, please correct “Furthermore”.
4. There is a mistake in Line 259 in the article “type1 IFN reponse exhibited”, please correct
“type1 IFN response exhibited”.
Title: Construction of a novel necroptosis-related lncRNA signature for prognosis prediction
in esophageal cancer
Version: 1 Date: 03 Jun 2022
Reviewer:  Weidong Ni
Reviewer's report:
It's a very interesting topic. Esophageal cancer is a significant malignant type of cancer with a
high mortality rate. In this study, the authors showed 6 necroptosis-related lncRNAs as a reliable
prognostic signature for survival, which offered novel potential prognostic markers for patients
with esophagus cancer. However, there are still some issues to be clarified before publication.
Major Comments:
1. In Figs 1, 6C, and 8, most font sizes utilized are too small to be legible. Please redesign to
enhance legibility.
2. Please add some comments for necroptosis-related lncRNA based signatures to predict
prognoses of other gastrointestinal tumors in the discussion section.
3. The conclusions are not rigorous and the current data only support the predicted prognosis,
without any data to support the prospect of treatment.
4. Line 206 in the article, why AMD12-AS1 was not shown in Fig 4D? And provide the titles
of the train, test, and entire set in Fig 4B-D?
5. It seems that the images in Fig.2 are not supporting to draw any conclusion, especially in
Fig 2B and 2C. Providing a cluster analysis of differential genes in Fig 2A may be beneficial to
explore the pattern of lncRNA expression in tumor prognosis.
6. The language of English was poor, and please modified.
Minor Comments:
1. The X- and Y-axis titles of many graphs are omitted, which makes it difficult to understand,
please present.
2. Please avoid the use of generic terms such as Line 270 in the article the word “good” and
replace it with more specific language.
3. There is a mistake in Line 263 in the article “Further more”, please correct “Furthermore”.
4. There is a mistake in Line 259 in the article “type1 IFN reponse exhibited”, please correct
“type1 IFN response exhibited”.
Please review this paper.
user
Title: Construction of a novel necroptosis-related lncRNA signature for prognosis prediction
in esophageal cancer
Version: 1 Date: 03 Jun 2022
Reviewer:  Weidong Ni
Reviewer's report:
It's a very interesting topic. Esophageal cancer is a significant malignant type of cancer with a
high mortality rate. In this study, the authors showed 6 necroptosis-related lncRNAs as a reliable
prognostic signature for survival, which offered novel potential prognostic markers for patients
with esophagus cancer. However, there are still some issues to be clarified before publication.
Major Comments:
1. In Figs 1, 6C, and 8, most font sizes utilized are too small to be legible. Please redesign to
enhance legibility.
2. Please add some comments for necroptosis-related lncRNA based signatures to predict
prognoses of other gastrointestinal tumors in the discussion section.
3. The conclusions are not rigorous and the current data only support the predicted prognosis,
without any data to support the prospect of treatment.
4. Line 206 in the article, why AMD12-AS1 was not shown in Fig 4D? And provide the titles
of the train, test, and entire set in Fig 4B-D?
5. It seems that the images in Fig.2 are not supporting to draw any conclusion, especially in
Fig 2B and 2C. Providing a cluster analysis of differential genes in Fig 2A may be beneficial to
explore the pattern of lncRNA expression in tumor prognosis.
6. The language of English was poor, and please modified.
Minor Comments:
1. The X- and Y-axis titles of many graphs are omitted, which makes it difficult to understand,
please present.
2. Please avoid the use of generic terms such as Line 270 in the article the word “good” and
replace it with more specific language.
3. There is a mistake in Line 263 in the article “Further more”, please correct “Furthermore”.
4. There is a mistake in Line 259 in the article “type1 IFN reponse exhibited”, please correct
“type1 IFN response exhibited”.
assistant