Reviewer's report
Title:Intestinal and neuronal myenteric adaptations in the small intestine induced
by a high-fat diet in mice
Version:1Date:15 July 2014
Reviewer: Shanthi Srinivasan
Reviewer's report:
In this interesting paper the authors assess the changes in the myenteric plexus
in the small intestine in mice fed a high fat diet for 8 weeks. They find t several
changes in intestinal morphology, myenteric neurons and specific neuronal
subtypes including nitregic neurons and VIP neurons. The findings are interesting
as the authors clearly characterize the changes in the neuronal innervation in
various segments of the small intestine.
1. Is the question posed by the authors well defined? Yes
2. Are the methods appropriate and well described? Yes
3. Are the data sound? Yes
4. Does the manuscript adhere to the relevant standards for reporting and data
deposition? Yes
5. Are the discussion and conclusions well balanced and adequately supported
by the data?
6. Are limitations of the work clearly stated? Yes
7. Do the authors clearly acknowledge any work upon which they are building,
both published and unpublished? Yes
8. Do the title and abstract accurately convey what has been found? Yes
9. Is the writing acceptable? Yes
• Minor Essential Revisions (such as missing labels on figures, or the wrong use
of a term, which the author can be trusted to correct)
I have only one suggestion-the authors should update reference 26 to the
published version of the article- Nezami et al, Gastroenterology, 2013
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Intestinal and neuronal myenteric adaptations in the small intestine induced
by a high-fat diet in mice
Version:1Date:15 July 2014
Reviewer: Shanthi Srinivasan
Reviewer's report:
In this interesting paper the authors assess the changes in the myenteric plexus
in the small intestine in mice fed a high fat diet for 8 weeks. They find t several
changes in intestinal morphology, myenteric neurons and specific neuronal
subtypes including nitregic neurons and VIP neurons. The findings are interesting
as the authors clearly characterize the changes in the neuronal innervation in
various segments of the small intestine.
1. Is the question posed by the authors well defined? Yes
2. Are the methods appropriate and well described? Yes
3. Are the data sound? Yes
4. Does the manuscript adhere to the relevant standards for reporting and data
deposition? Yes
5. Are the discussion and conclusions well balanced and adequately supported
by the data?
6. Are limitations of the work clearly stated? Yes
7. Do the authors clearly acknowledge any work upon which they are building,
both published and unpublished? Yes
8. Do the title and abstract accurately convey what has been found? Yes
9. Is the writing acceptable? Yes
• Minor Essential Revisions (such as missing labels on figures, or the wrong use
of a term, which the author can be trusted to correct)
I have only one suggestion-the authors should update reference 26 to the
published version of the article- Nezami et al, Gastroenterology, 2013
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Intestinal and neuronal myenteric adaptations in the small intestine induced
by a high-fat diet in mice
Version:1Date:15 July 2014
Reviewer: Shanthi Srinivasan
Reviewer's report:
In this interesting paper the authors assess the changes in the myenteric plexus
in the small intestine in mice fed a high fat diet for 8 weeks. They find t several
changes in intestinal morphology, myenteric neurons and specific neuronal
subtypes including nitregic neurons and VIP neurons. The findings are interesting
as the authors clearly characterize the changes in the neuronal innervation in
various segments of the small intestine.
1. Is the question posed by the authors well defined? Yes
2. Are the methods appropriate and well described? Yes
3. Are the data sound? Yes
4. Does the manuscript adhere to the relevant standards for reporting and data
deposition? Yes
5. Are the discussion and conclusions well balanced and adequately supported
by the data?
6. Are limitations of the work clearly stated? Yes
7. Do the authors clearly acknowledge any work upon which they are building,
both published and unpublished? Yes
8. Do the title and abstract accurately convey what has been found? Yes
9. Is the writing acceptable? Yes
• Minor Essential Revisions (such as missing labels on figures, or the wrong use
of a term, which the author can be trusted to correct)
I have only one suggestion-the authors should update reference 26 to the
published version of the article- Nezami et al, Gastroenterology, 2013
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
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