Title: TITLE: The Association Between Blood Pressure and Gallstones and the Age of First
Cholecystectomy in U.S. Adults: Results from a Cross-Sectional Study
Version: 1 Date: 11 Dec 2024
Reviewer:  Yüksel Do#an
Reviewer's report:
The text is detailed and comprehensive, covering studies on hypertension and its association
with gallstones and cholecystectomy. However, clarity and readability could be improved.
I think that the practical implications of the findings should be succinctly emphasised... For
example, it is appropriate to state how these findings may influence public health strategies or
clinical guidelines...
A clearer transition from the global prevalence and risk factors of gallstones to the study's focus
on hypertension and gallbladder disease needs to be added.
It is appropriate to emphasise why the association between systolic blood pressure (SBP) and
age at first cholecystectomy is a new and important area of research ...
Kindly Consider breaking large tables into smaller, thematic tables for better readability.
Kindly Use simplified labels for figures and tables (e.g., ‘Figure 2: SBP and Age Correlation’).
Kindly Make sure figure captions are descriptive, e.g., the legend for Figure 3 could clarify how
the red line indicates threshold.
Kindly Address limitations such as the cross-sectional nature of the NHANES data or potential
confounders not accounted for.
Title: TITLE: The Association Between Blood Pressure and Gallstones and the Age of First
Cholecystectomy in U.S. Adults: Results from a Cross-Sectional Study
Version: 1 Date: 11 Dec 2024
Reviewer:  Yüksel Do#an
Reviewer's report:
The text is detailed and comprehensive, covering studies on hypertension and its association
with gallstones and cholecystectomy. However, clarity and readability could be improved.
I think that the practical implications of the findings should be succinctly emphasised... For
example, it is appropriate to state how these findings may influence public health strategies or
clinical guidelines...
A clearer transition from the global prevalence and risk factors of gallstones to the study's focus
on hypertension and gallbladder disease needs to be added.
It is appropriate to emphasise why the association between systolic blood pressure (SBP) and
age at first cholecystectomy is a new and important area of research ...
Kindly Consider breaking large tables into smaller, thematic tables for better readability.
Kindly Use simplified labels for figures and tables (e.g., ‘Figure 2: SBP and Age Correlation’).
Kindly Make sure figure captions are descriptive, e.g., the legend for Figure 3 could clarify how
the red line indicates threshold.
Kindly Address limitations such as the cross-sectional nature of the NHANES data or potential
confounders not accounted for.
Please review this paper.
user
Title: TITLE: The Association Between Blood Pressure and Gallstones and the Age of First
Cholecystectomy in U.S. Adults: Results from a Cross-Sectional Study
Version: 1 Date: 11 Dec 2024
Reviewer:  Yüksel Do#an
Reviewer's report:
The text is detailed and comprehensive, covering studies on hypertension and its association
with gallstones and cholecystectomy. However, clarity and readability could be improved.
I think that the practical implications of the findings should be succinctly emphasised... For
example, it is appropriate to state how these findings may influence public health strategies or
clinical guidelines...
A clearer transition from the global prevalence and risk factors of gallstones to the study's focus
on hypertension and gallbladder disease needs to be added.
It is appropriate to emphasise why the association between systolic blood pressure (SBP) and
age at first cholecystectomy is a new and important area of research ...
Kindly Consider breaking large tables into smaller, thematic tables for better readability.
Kindly Use simplified labels for figures and tables (e.g., ‘Figure 2: SBP and Age Correlation’).
Kindly Make sure figure captions are descriptive, e.g., the legend for Figure 3 could clarify how
the red line indicates threshold.
Kindly Address limitations such as the cross-sectional nature of the NHANES data or potential
confounders not accounted for.
assistant