Title: Clinical features of inflammatory bowel disease unclassified: a case-control study
Version: 1 Date: 11 Oct 2023
Reviewer's report:
This reported the disease course of IBDU. Accurate diagnosis of inflammatory bowel disease
is important for appropriate treatment. IBDU includes three types, such as CD, ulcerative
colitis (UC) and true unclassified IBD. Difinitive criteria of CD was proposed in 2000 (Dis
Colon Rectum. 2000;43(10 Suppl):S85-93 ). But the criteria of CD has not been defined in
many reports. CD has been diagnosed comprehensively based on clinical, endoscopic and
histopathologic features. Therefore, diagnosis of IBDU ends up being ambiguous in practice.
The authors pointed out of that episode of hemorrhage implies Crohn’s disease (CD).
The authors showed that many characteristics of IBDU is intermediate of UC and CD. I think
that this just reflects that this group includes both UC and CD. It is better to compare to UC-
reclassified and CD-reclassified patients.
There are some minor points:
There are miss spellings, such as fissing and ulcerationr.
Decrease of 2mg/dL of hemoglobin does not cause anemia.
The duration from symptoms onset to diagnosis of IBDU were weeks or months?
In table 3, descending colon (75.7.5%)?
Title: Clinical features of inflammatory bowel disease unclassified: a case-control study
Version: 1 Date: 11 Oct 2023
Reviewer's report:
This reported the disease course of IBDU. Accurate diagnosis of inflammatory bowel disease
is important for appropriate treatment. IBDU includes three types, such as CD, ulcerative
colitis (UC) and true unclassified IBD. Difinitive criteria of CD was proposed in 2000 (Dis
Colon Rectum. 2000;43(10 Suppl):S85-93 ). But the criteria of CD has not been defined in
many reports. CD has been diagnosed comprehensively based on clinical, endoscopic and
histopathologic features. Therefore, diagnosis of IBDU ends up being ambiguous in practice.
The authors pointed out of that episode of hemorrhage implies Crohn’s disease (CD).
The authors showed that many characteristics of IBDU is intermediate of UC and CD. I think
that this just reflects that this group includes both UC and CD. It is better to compare to UC-
reclassified and CD-reclassified patients.
There are some minor points:
There are miss spellings, such as fissing and ulcerationr.
Decrease of 2mg/dL of hemoglobin does not cause anemia.
The duration from symptoms onset to diagnosis of IBDU were weeks or months?
In table 3, descending colon (75.7.5%)?
Please review this paper.
user
Title: Clinical features of inflammatory bowel disease unclassified: a case-control study
Version: 1 Date: 11 Oct 2023
Reviewer's report:
This reported the disease course of IBDU. Accurate diagnosis of inflammatory bowel disease
is important for appropriate treatment. IBDU includes three types, such as CD, ulcerative
colitis (UC) and true unclassified IBD. Difinitive criteria of CD was proposed in 2000 (Dis
Colon Rectum. 2000;43(10 Suppl):S85-93 ). But the criteria of CD has not been defined in
many reports. CD has been diagnosed comprehensively based on clinical, endoscopic and
histopathologic features. Therefore, diagnosis of IBDU ends up being ambiguous in practice.
The authors pointed out of that episode of hemorrhage implies Crohn’s disease (CD).
The authors showed that many characteristics of IBDU is intermediate of UC and CD. I think
that this just reflects that this group includes both UC and CD. It is better to compare to UC-
reclassified and CD-reclassified patients.
There are some minor points:
There are miss spellings, such as fissing and ulcerationr.
Decrease of 2mg/dL of hemoglobin does not cause anemia.
The duration from symptoms onset to diagnosis of IBDU were weeks or months?
In table 3, descending colon (75.7.5%)?
assistant