Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 6 Date: 22 Jan 2025
Reviewer's report:
Milo et al present a systematic review with meta-analysis that aimed to evaluate the available
data on health-related quality of life (HRQoL) in pediatric patients with intestinal failure,
excluding those with neurodevelopmental delay, compared with healthy controls. With a
growing population of children with intestinal failure and long-term parenteral nutrition needs,
understanding the impact of this disease on the HRQoL of patients is imperative. The authors
attempted to summarize the available evidence, excluding patients with neurodevelopmental
delay, which could independently affect their HRQOL. The manuscript is clear and easy to
follow, with adequate methodological design.
The authors have adequately addressed previous  comments and suggestions.
Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 6 Date: 22 Jan 2025
Reviewer's report:
Milo et al present a systematic review with meta-analysis that aimed to evaluate the available
data on health-related quality of life (HRQoL) in pediatric patients with intestinal failure,
excluding those with neurodevelopmental delay, compared with healthy controls. With a
growing population of children with intestinal failure and long-term parenteral nutrition needs,
understanding the impact of this disease on the HRQoL of patients is imperative. The authors
attempted to summarize the available evidence, excluding patients with neurodevelopmental
delay, which could independently affect their HRQOL. The manuscript is clear and easy to
follow, with adequate methodological design.
The authors have adequately addressed previous  comments and suggestions.
Please review this paper.
user
Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 6 Date: 22 Jan 2025
Reviewer's report:
Milo et al present a systematic review with meta-analysis that aimed to evaluate the available
data on health-related quality of life (HRQoL) in pediatric patients with intestinal failure,
excluding those with neurodevelopmental delay, compared with healthy controls. With a
growing population of children with intestinal failure and long-term parenteral nutrition needs,
understanding the impact of this disease on the HRQoL of patients is imperative. The authors
attempted to summarize the available evidence, excluding patients with neurodevelopmental
delay, which could independently affect their HRQOL. The manuscript is clear and easy to
follow, with adequate methodological design.
The authors have adequately addressed previous  comments and suggestions.
assistant