Title: A radiomics model fusing clinical features to predict microsatellite status preoperatively
in colorectal cancer liver metastasis
Version: 3 Date: 09 Feb 2023
Reviewer's report:
In this manuscript, “A radiomics model fusing clinical features to predict microsatellite status
preoperatively in colorectal cancer liver metastasis,” the authors aimed to use enhanced CT
images for preoperative noninvasive prediction of microsatellite status in patients with liver
metastasis from colorectal cancer. The structure of the manuscript was not easy to understand. In
addition, although the authors attempted to present more measurements to describe the models,
it may make the readers some confusion about the study aim due to the un-clear description. I
have some concerns as below,
1. The section of introduction was too long, the authors should make the structure simplify to
present your research background and questions.
2. The authors should describe the sample sizes and statistical power in this study. Due to the
sample sizes is less, how could the authors establish the reasonable model?
3. How about the missing data in all interested variables? In Table1, we could find there is
missing data in the training group.
4. Could the authors explain the distribution of Tumor Location presented the difference? I think
it may affect the model building.
5. In Figure3, the authors should indicate the difference between three models.
6. Although the authors stated the limitation of this study, they did not offer any approach to
improve these limitation. Thus, I do not think the model from this study could assist in clinical
decision-making by providing personalized treatment plans for patients with liver metastasis
from colorectal cancer.
7. The approval number for the Ethics committee should be offered.
Title: A radiomics model fusing clinical features to predict microsatellite status preoperatively
in colorectal cancer liver metastasis
Version: 3 Date: 09 Feb 2023
Reviewer's report:
In this manuscript, “A radiomics model fusing clinical features to predict microsatellite status
preoperatively in colorectal cancer liver metastasis,” the authors aimed to use enhanced CT
images for preoperative noninvasive prediction of microsatellite status in patients with liver
metastasis from colorectal cancer. The structure of the manuscript was not easy to understand. In
addition, although the authors attempted to present more measurements to describe the models,
it may make the readers some confusion about the study aim due to the un-clear description. I
have some concerns as below,
1. The section of introduction was too long, the authors should make the structure simplify to
present your research background and questions.
2. The authors should describe the sample sizes and statistical power in this study. Due to the
sample sizes is less, how could the authors establish the reasonable model?
3. How about the missing data in all interested variables? In Table1, we could find there is
missing data in the training group.
4. Could the authors explain the distribution of Tumor Location presented the difference? I think
it may affect the model building.
5. In Figure3, the authors should indicate the difference between three models.
6. Although the authors stated the limitation of this study, they did not offer any approach to
improve these limitation. Thus, I do not think the model from this study could assist in clinical
decision-making by providing personalized treatment plans for patients with liver metastasis
from colorectal cancer.
7. The approval number for the Ethics committee should be offered.
Please review this paper.
user
Title: A radiomics model fusing clinical features to predict microsatellite status preoperatively
in colorectal cancer liver metastasis
Version: 3 Date: 09 Feb 2023
Reviewer's report:
In this manuscript, “A radiomics model fusing clinical features to predict microsatellite status
preoperatively in colorectal cancer liver metastasis,” the authors aimed to use enhanced CT
images for preoperative noninvasive prediction of microsatellite status in patients with liver
metastasis from colorectal cancer. The structure of the manuscript was not easy to understand. In
addition, although the authors attempted to present more measurements to describe the models,
it may make the readers some confusion about the study aim due to the un-clear description. I
have some concerns as below,
1. The section of introduction was too long, the authors should make the structure simplify to
present your research background and questions.
2. The authors should describe the sample sizes and statistical power in this study. Due to the
sample sizes is less, how could the authors establish the reasonable model?
3. How about the missing data in all interested variables? In Table1, we could find there is
missing data in the training group.
4. Could the authors explain the distribution of Tumor Location presented the difference? I think
it may affect the model building.
5. In Figure3, the authors should indicate the difference between three models.
6. Although the authors stated the limitation of this study, they did not offer any approach to
improve these limitation. Thus, I do not think the model from this study could assist in clinical
decision-making by providing personalized treatment plans for patients with liver metastasis
from colorectal cancer.
7. The approval number for the Ethics committee should be offered.
assistant