Reviewer's report
Title:Lack of efficacy of blueberry in nutritional prevention of
azoxymethane-initiated cancers of rat small intestine and colon
Version: 1Date:23 June 2009
Reviewer: Denis Corpet
Reviewer's report:
This is a well written, well designed study of “anti-cancer” effect of freeze-dried
blueberry on an accepted animal model of chemically induced colorectal cancer.
The results show tha blueberry has little or no effect. Additional findings concern
gender differences, and intestinal sites differences.
1- The authors should cite, and comment, a highly relevant paper on the same
topic, but using a different animal model, and a different “blueberry powder”:
Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ,
Marczylo TH.
Int J Cancer. 2006 Nov 1;119(9):2213-20.
Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on
adenoma development in the ApcMin mouse model of intestinal
carcinogenesis--relationship with tissue anthocyanin levels.
2- Reviewer thinks that one of the cited references (ref.26), which is highly
relevant to the present study, contains “very strange” data that are in strong
contrast with the present MS findings. Reviewer suggests the authors could still
cite ref.26, but that their discussion should leave some “doubts” on ref.26 results.
26. Boateng J, Verghese M, Shackelford L, Walker LT, Khatiwada J, Ogutu S,
Williams DS, Jones J, Guyton M, et al.: Selected fruits reduce azoxymethane
(AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food
Chem Toxicol 2007, 45:725-32.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Lack of efficacy of blueberry in nutritional prevention of
azoxymethane-initiated cancers of rat small intestine and colon
Version: 1Date:23 June 2009
Reviewer: Denis Corpet
Reviewer's report:
This is a well written, well designed study of “anti-cancer” effect of freeze-dried
blueberry on an accepted animal model of chemically induced colorectal cancer.
The results show tha blueberry has little or no effect. Additional findings concern
gender differences, and intestinal sites differences.
1- The authors should cite, and comment, a highly relevant paper on the same
topic, but using a different animal model, and a different “blueberry powder”:
Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ,
Marczylo TH.
Int J Cancer. 2006 Nov 1;119(9):2213-20.
Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on
adenoma development in the ApcMin mouse model of intestinal
carcinogenesis--relationship with tissue anthocyanin levels.
2- Reviewer thinks that one of the cited references (ref.26), which is highly
relevant to the present study, contains “very strange” data that are in strong
contrast with the present MS findings. Reviewer suggests the authors could still
cite ref.26, but that their discussion should leave some “doubts” on ref.26 results.
26. Boateng J, Verghese M, Shackelford L, Walker LT, Khatiwada J, Ogutu S,
Williams DS, Jones J, Guyton M, et al.: Selected fruits reduce azoxymethane
(AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food
Chem Toxicol 2007, 45:725-32.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Lack of efficacy of blueberry in nutritional prevention of
azoxymethane-initiated cancers of rat small intestine and colon
Version: 1Date:23 June 2009
Reviewer: Denis Corpet
Reviewer's report:
This is a well written, well designed study of “anti-cancer” effect of freeze-dried
blueberry on an accepted animal model of chemically induced colorectal cancer.
The results show tha blueberry has little or no effect. Additional findings concern
gender differences, and intestinal sites differences.
1- The authors should cite, and comment, a highly relevant paper on the same
topic, but using a different animal model, and a different “blueberry powder”:
Cooke D, Schwarz M, Boocock D, Winterhalter P, Steward WP, Gescher AJ,
Marczylo TH.
Int J Cancer. 2006 Nov 1;119(9):2213-20.
Effect of cyanidin-3-glucoside and an anthocyanin mixture from bilberry on
adenoma development in the ApcMin mouse model of intestinal
carcinogenesis--relationship with tissue anthocyanin levels.
2- Reviewer thinks that one of the cited references (ref.26), which is highly
relevant to the present study, contains “very strange” data that are in strong
contrast with the present MS findings. Reviewer suggests the authors could still
cite ref.26, but that their discussion should leave some “doubts” on ref.26 results.
26. Boateng J, Verghese M, Shackelford L, Walker LT, Khatiwada J, Ogutu S,
Williams DS, Jones J, Guyton M, et al.: Selected fruits reduce azoxymethane
(AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food
Chem Toxicol 2007, 45:725-32.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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