Reviewer's report
Title:Screening for celiac disease in 1st degree relatives: a 10-year follow-up
study
Version: 3Date:15 May 2013
Reviewer: Federico Biagi
Reviewer's report:
In this paper Rosa Harumi Uenishi et al. studied the incidence of coeliac disease
(CD) in first-degree relatives (FDR) of coeliac patients. Due to the high
prevalence of CD in the general population and among FDR, this is a very import
issue that, however, has been addressed only by few studies. I have got the
following comments:
1. The statistical analysis can be improved. Binomial 95% confidence interval for
prevalence and incidence are necessary. Annual incidence needs to be
indicated.
2. I assume demographic characteristics of the FDR studied are in the annexed
table 1 but I could not open it. Anyway, this is a very important point and I would
provide sex and age of the FDR in the methods section.
3. The authors studied both children and adult FDR of coeliac patients. Since the
incidence of CD among FDR could be different in different age groups (Biagi F, J
Clin Gastroenterol 2009;43:3-4), I would love to see whether there is any
differences between children and adult FDR.
4. I would indicate in the methods section that FDR found to be positive to TTG
ab were underwent upper GI endoscopy with duodenal biopsies.
5. English must be improved and spelling must be checked.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Screening for celiac disease in 1st degree relatives: a 10-year follow-up
study
Version: 3Date:15 May 2013
Reviewer: Federico Biagi
Reviewer's report:
In this paper Rosa Harumi Uenishi et al. studied the incidence of coeliac disease
(CD) in first-degree relatives (FDR) of coeliac patients. Due to the high
prevalence of CD in the general population and among FDR, this is a very import
issue that, however, has been addressed only by few studies. I have got the
following comments:
1. The statistical analysis can be improved. Binomial 95% confidence interval for
prevalence and incidence are necessary. Annual incidence needs to be
indicated.
2. I assume demographic characteristics of the FDR studied are in the annexed
table 1 but I could not open it. Anyway, this is a very important point and I would
provide sex and age of the FDR in the methods section.
3. The authors studied both children and adult FDR of coeliac patients. Since the
incidence of CD among FDR could be different in different age groups (Biagi F, J
Clin Gastroenterol 2009;43:3-4), I would love to see whether there is any
differences between children and adult FDR.
4. I would indicate in the methods section that FDR found to be positive to TTG
ab were underwent upper GI endoscopy with duodenal biopsies.
5. English must be improved and spelling must be checked.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Screening for celiac disease in 1st degree relatives: a 10-year follow-up
study
Version: 3Date:15 May 2013
Reviewer: Federico Biagi
Reviewer's report:
In this paper Rosa Harumi Uenishi et al. studied the incidence of coeliac disease
(CD) in first-degree relatives (FDR) of coeliac patients. Due to the high
prevalence of CD in the general population and among FDR, this is a very import
issue that, however, has been addressed only by few studies. I have got the
following comments:
1. The statistical analysis can be improved. Binomial 95% confidence interval for
prevalence and incidence are necessary. Annual incidence needs to be
indicated.
2. I assume demographic characteristics of the FDR studied are in the annexed
table 1 but I could not open it. Anyway, this is a very important point and I would
provide sex and age of the FDR in the methods section.
3. The authors studied both children and adult FDR of coeliac patients. Since the
incidence of CD among FDR could be different in different age groups (Biagi F, J
Clin Gastroenterol 2009;43:3-4), I would love to see whether there is any
differences between children and adult FDR.
4. I would indicate in the methods section that FDR found to be positive to TTG
ab were underwent upper GI endoscopy with duodenal biopsies.
5. English must be improved and spelling must be checked.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
'I declare that I have no competing interests'
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