Reviewer's report 
 Grey scale enhancement by a new self-made contrast agent in early cirrhotic stage of rabbit liver Title: 
 1  28 November 2006 Version: Date: 
 Adrian Lim Reviewer: 
Reviewer's report: 
General 
The introduction and also discussion needs to be revised and include many other papers on transit itmes 
particularly with relation to a fibrosis model in humans. The authors need to complete a more thorough literature search. ------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be 
reached) 
1. There is a lack of controls and any such data would enhance this study 
2. The authors need to explain their measurement of arrival times and also provide examples of how these 
were measured. 
3.The results in table 1 need further statistical analysis. Only an ANOVA has been performed and the 
authors need to show us if there is any intergroup significance with pairwise comparisons. 
4.There are a lot of misused terms and the english is confusing - this would need editing. 
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Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
 Unable to decide on acceptance or rejection until the authors have responded to the major What next?: 
compulsory revisions 
 An article of limited interest Level of interest: 
 Not suitable for publication unless extensively edited Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests' 
Reviewer's report 
 Grey scale enhancement by a new self-made contrast agent in early cirrhotic stage of rabbit liver Title: 
 1  28 November 2006 Version: Date: 
 Adrian Lim Reviewer: 
Reviewer's report: 
General 
The introduction and also discussion needs to be revised and include many other papers on transit itmes 
particularly with relation to a fibrosis model in humans. The authors need to complete a more thorough literature search. ------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be 
reached) 
1. There is a lack of controls and any such data would enhance this study 
2. The authors need to explain their measurement of arrival times and also provide examples of how these 
were measured. 
3.The results in table 1 need further statistical analysis. Only an ANOVA has been performed and the 
authors need to show us if there is any intergroup significance with pairwise comparisons. 
4.There are a lot of misused terms and the english is confusing - this would need editing. 
--------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
 Unable to decide on acceptance or rejection until the authors have responded to the major What next?: 
compulsory revisions 
 An article of limited interest Level of interest: 
 Not suitable for publication unless extensively edited Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests' 
Please review this paper.
user
Reviewer's report 
 Grey scale enhancement by a new self-made contrast agent in early cirrhotic stage of rabbit liver Title: 
 1  28 November 2006 Version: Date: 
 Adrian Lim Reviewer: 
Reviewer's report: 
General 
The introduction and also discussion needs to be revised and include many other papers on transit itmes 
particularly with relation to a fibrosis model in humans. The authors need to complete a more thorough literature search. ------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be 
reached) 
1. There is a lack of controls and any such data would enhance this study 
2. The authors need to explain their measurement of arrival times and also provide examples of how these 
were measured. 
3.The results in table 1 need further statistical analysis. Only an ANOVA has been performed and the 
authors need to show us if there is any intergroup significance with pairwise comparisons. 
4.There are a lot of misused terms and the english is confusing - this would need editing. 
--------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
 Unable to decide on acceptance or rejection until the authors have responded to the major What next?: 
compulsory revisions 
 An article of limited interest Level of interest: 
 Not suitable for publication unless extensively edited Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
'I declare that I have no competing interests' 
assistant