Title: Application of antithrombotic drugs and risk factor analysis in ICU patients with lower
gastrointestinal bleeding from MIMIC-IV
Version: 4 Date: 16 Jun 2024
Reviewer:  Ali S. Taha
Reviewer's report:
Objective: it would be easier to say: To assess the effects of continued use of antithrombotic
therapy on the outcomes of lower GI bleeding (LIGB) in ICU patients focusing on in-hospital
mortality, rebleeding, and length of hospital and ICU stays, as compared with those not taking
these agents.
What was the definition of LGIB: this needs to be mentioned in Methods
This study was a retrospective observational study of patients using the multi-center Medical
Information Mart for Intensive Care database (MIMIC-IV 2.2). The assumption from this is that
the patients were living in USA. The title and the abstract should mention that the study used
the MIMIC-IV database, maintained by the Massachusetts Institute of Technology and Beth
Israel Deaconess Medical Center. Otherwise, the readers will be made to think that it included
Chinese patients.
Table-1 should start with a row saying “Patients with Full Details (for the first 3 columns”, and
those “analyzed by propensity score matching (PSM)” for the last 3 columns
Title: Application of antithrombotic drugs and risk factor analysis in ICU patients with lower
gastrointestinal bleeding from MIMIC-IV
Version: 4 Date: 16 Jun 2024
Reviewer:  Ali S. Taha
Reviewer's report:
Objective: it would be easier to say: To assess the effects of continued use of antithrombotic
therapy on the outcomes of lower GI bleeding (LIGB) in ICU patients focusing on in-hospital
mortality, rebleeding, and length of hospital and ICU stays, as compared with those not taking
these agents.
What was the definition of LGIB: this needs to be mentioned in Methods
This study was a retrospective observational study of patients using the multi-center Medical
Information Mart for Intensive Care database (MIMIC-IV 2.2). The assumption from this is that
the patients were living in USA. The title and the abstract should mention that the study used
the MIMIC-IV database, maintained by the Massachusetts Institute of Technology and Beth
Israel Deaconess Medical Center. Otherwise, the readers will be made to think that it included
Chinese patients.
Table-1 should start with a row saying “Patients with Full Details (for the first 3 columns”, and
those “analyzed by propensity score matching (PSM)” for the last 3 columns
Please review this paper.
user
Title: Application of antithrombotic drugs and risk factor analysis in ICU patients with lower
gastrointestinal bleeding from MIMIC-IV
Version: 4 Date: 16 Jun 2024
Reviewer:  Ali S. Taha
Reviewer's report:
Objective: it would be easier to say: To assess the effects of continued use of antithrombotic
therapy on the outcomes of lower GI bleeding (LIGB) in ICU patients focusing on in-hospital
mortality, rebleeding, and length of hospital and ICU stays, as compared with those not taking
these agents.
What was the definition of LGIB: this needs to be mentioned in Methods
This study was a retrospective observational study of patients using the multi-center Medical
Information Mart for Intensive Care database (MIMIC-IV 2.2). The assumption from this is that
the patients were living in USA. The title and the abstract should mention that the study used
the MIMIC-IV database, maintained by the Massachusetts Institute of Technology and Beth
Israel Deaconess Medical Center. Otherwise, the readers will be made to think that it included
Chinese patients.
Table-1 should start with a row saying “Patients with Full Details (for the first 3 columns”, and
those “analyzed by propensity score matching (PSM)” for the last 3 columns
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