Title: Association between dietary antioxidant index and risk of Helicobacter pylori infection
among adults: a case–control study
Version: 2 Date: 09 Jul 2022
Reviewer:  Felipe Mazzoleni
Reviewer's report:
Assessing the role of diet in H. pylori infection can help develop strategies to treat it.
Main comments:
1. H. pylori detection was made by different methods. Since the selection of patients was
determined by the presence or absence of H. pylori, it is better to use only one method, preferably
the gold standard, the anatomopathological. Without that,  describe which tests were used, and
their percentage, in each group, and assess whether there is significant differences.
2. Although patients were compared according to age, in baseline data, there was a significant
age difference between groups, which can generate a significant bias for this study, since age
influences H. pylori prevalence.
3. Many variables interfere with the prevalence of H. pylori, making it extremely important to
add in the multivariate analysis, for example, years of education.
4. Positive points: the author described the study limitations and the conclusion is consistent
with the results (although the title suggests a risk association). All the study tools to evaluate
the data are adequate, with validated questionnaires and index (DAI), which is mandatory for
studies that assess diet habits.
Minor comments:
1. I suggest a specialized translator in English medical articles translate the article.
2. H. pylori should be written in italics.
Title: Association between dietary antioxidant index and risk of Helicobacter pylori infection
among adults: a case–control study
Version: 2 Date: 09 Jul 2022
Reviewer:  Felipe Mazzoleni
Reviewer's report:
Assessing the role of diet in H. pylori infection can help develop strategies to treat it.
Main comments:
1. H. pylori detection was made by different methods. Since the selection of patients was
determined by the presence or absence of H. pylori, it is better to use only one method, preferably
the gold standard, the anatomopathological. Without that,  describe which tests were used, and
their percentage, in each group, and assess whether there is significant differences.
2. Although patients were compared according to age, in baseline data, there was a significant
age difference between groups, which can generate a significant bias for this study, since age
influences H. pylori prevalence.
3. Many variables interfere with the prevalence of H. pylori, making it extremely important to
add in the multivariate analysis, for example, years of education.
4. Positive points: the author described the study limitations and the conclusion is consistent
with the results (although the title suggests a risk association). All the study tools to evaluate
the data are adequate, with validated questionnaires and index (DAI), which is mandatory for
studies that assess diet habits.
Minor comments:
1. I suggest a specialized translator in English medical articles translate the article.
2. H. pylori should be written in italics.
Please review this paper.
user
Title: Association between dietary antioxidant index and risk of Helicobacter pylori infection
among adults: a case–control study
Version: 2 Date: 09 Jul 2022
Reviewer:  Felipe Mazzoleni
Reviewer's report:
Assessing the role of diet in H. pylori infection can help develop strategies to treat it.
Main comments:
1. H. pylori detection was made by different methods. Since the selection of patients was
determined by the presence or absence of H. pylori, it is better to use only one method, preferably
the gold standard, the anatomopathological. Without that,  describe which tests were used, and
their percentage, in each group, and assess whether there is significant differences.
2. Although patients were compared according to age, in baseline data, there was a significant
age difference between groups, which can generate a significant bias for this study, since age
influences H. pylori prevalence.
3. Many variables interfere with the prevalence of H. pylori, making it extremely important to
add in the multivariate analysis, for example, years of education.
4. Positive points: the author described the study limitations and the conclusion is consistent
with the results (although the title suggests a risk association). All the study tools to evaluate
the data are adequate, with validated questionnaires and index (DAI), which is mandatory for
studies that assess diet habits.
Minor comments:
1. I suggest a specialized translator in English medical articles translate the article.
2. H. pylori should be written in italics.
assistant