Reviewer's report
Title:Gastroparesis is associated with oxytocin deficiency, oesophageal
dysmotility with hyperCCKemia, and autonomic neuropathy with
hypergastrinemia
Version: 1Date:20 October 2008
Reviewer: PAULUS S. WANG
Reviewer's report:
General Comments:
The purpose of this study is to investigate if the plasma concentration of oxytocin,
cholecystokinin(CCK), gastrin and vasopressin differ between diabetic patients
with gastrointestinal(GI)normal function and dysfunction. This is an interesting
topic and worthy to publish but it requires minor revisions.
Major Compulsory Revisions:
The length of introduction seems too short. It is known that gastroparesis is one
of the best examples of diabetic GI disturbances. However, the reason why the
hormone concentrations of plasma in relation to oesophageal dysmotility and
autonomic neuropathy were observed was not mentioned. The authors should
make a brief statement on the relationship in diabetic GI disturbances. That will
make the purpose of the present study more clear.
In this study, authors show that patients with diabetes mellitus and normal gastric
emptying have a postprandial promotion in oxytocin secretion. There is no
significant difference in postprandial CCK or gastrin secretion in patients with and
without delayed gastric emptying. However, in patients with oesophageal
dysmotility the basal concentration of CCK tend to be higher, and with autonomic
neuropathy the gastrin concentrations were increased.
Minor Essential Revisions
Figure
Page17,Reference 15, the "et al." shouldbe replaced with the complete author's
name.
Page25, Figure 1C, the gastrinpeak group has missed upper
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Gastroparesis is associated with oxytocin deficiency, oesophageal
dysmotility with hyperCCKemia, and autonomic neuropathy with
hypergastrinemia
Version: 1Date:20 October 2008
Reviewer: PAULUS S. WANG
Reviewer's report:
General Comments:
The purpose of this study is to investigate if the plasma concentration of oxytocin,
cholecystokinin(CCK), gastrin and vasopressin differ between diabetic patients
with gastrointestinal(GI)normal function and dysfunction. This is an interesting
topic and worthy to publish but it requires minor revisions.
Major Compulsory Revisions:
The length of introduction seems too short. It is known that gastroparesis is one
of the best examples of diabetic GI disturbances. However, the reason why the
hormone concentrations of plasma in relation to oesophageal dysmotility and
autonomic neuropathy were observed was not mentioned. The authors should
make a brief statement on the relationship in diabetic GI disturbances. That will
make the purpose of the present study more clear.
In this study, authors show that patients with diabetes mellitus and normal gastric
emptying have a postprandial promotion in oxytocin secretion. There is no
significant difference in postprandial CCK or gastrin secretion in patients with and
without delayed gastric emptying. However, in patients with oesophageal
dysmotility the basal concentration of CCK tend to be higher, and with autonomic
neuropathy the gastrin concentrations were increased.
Minor Essential Revisions
Figure
Page17,Reference 15, the "et al." shouldbe replaced with the complete author's
name.
Page25, Figure 1C, the gastrinpeak group has missed upper
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Gastroparesis is associated with oxytocin deficiency, oesophageal
dysmotility with hyperCCKemia, and autonomic neuropathy with
hypergastrinemia
Version: 1Date:20 October 2008
Reviewer: PAULUS S. WANG
Reviewer's report:
General Comments:
The purpose of this study is to investigate if the plasma concentration of oxytocin,
cholecystokinin(CCK), gastrin and vasopressin differ between diabetic patients
with gastrointestinal(GI)normal function and dysfunction. This is an interesting
topic and worthy to publish but it requires minor revisions.
Major Compulsory Revisions:
The length of introduction seems too short. It is known that gastroparesis is one
of the best examples of diabetic GI disturbances. However, the reason why the
hormone concentrations of plasma in relation to oesophageal dysmotility and
autonomic neuropathy were observed was not mentioned. The authors should
make a brief statement on the relationship in diabetic GI disturbances. That will
make the purpose of the present study more clear.
In this study, authors show that patients with diabetes mellitus and normal gastric
emptying have a postprandial promotion in oxytocin secretion. There is no
significant difference in postprandial CCK or gastrin secretion in patients with and
without delayed gastric emptying. However, in patients with oesophageal
dysmotility the basal concentration of CCK tend to be higher, and with autonomic
neuropathy the gastrin concentrations were increased.
Minor Essential Revisions
Figure
Page17,Reference 15, the "et al." shouldbe replaced with the complete author's
name.
Page25, Figure 1C, the gastrinpeak group has missed upper
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant