Reviewer's report
Title:Cyclic Vomiting Syndrome (CVS): is there a difference based on onset;
pediatric vs. adult?
Version: 1Date:19 January 2012
Reviewer: Tuba Esfandyari
Reviewer's report:
1. This is an interesting study to compare the adult and pediatric patients with
cyclic vomiting syndrome. Since, different genetic backgrounds have been
proposed to be associated with difference in age of onset.
2. Major Compulsory Revision
Authors have done a great job comparing the pediatric vs. adult groups with CVS
in regard to demographics and disease characteristics. 3. More detailed
description of comparison between pediatric vs. adult patients with CVS in regard
to treatment and response is extremely important. Due to small number of
pediatric patients with CVS (n=29), the number of pediatric patients with CVS
might not be large enough in some categories to make the final conclusion of “no
differences in response to treatment between pediatric vs. adult patients with
CVS”.
4. Major Compulsory Revision
Authors discuss about the limitations of this study in detail. This study is one of
the largest studies characterizing adult vs. pediatric patients with CVS, but still
has relatively small number of pediatric patients. Considering the retrospective
nature of the study and missing documented data, this might be a significant
limiting factor in making clinical judgment on response to treatment. Details on
the number of collected data in treatment and response to treatment in pediatric
vs. adult patients with CVS is of great importance.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Cyclic Vomiting Syndrome (CVS): is there a difference based on onset;
pediatric vs. adult?
Version: 1Date:19 January 2012
Reviewer: Tuba Esfandyari
Reviewer's report:
1. This is an interesting study to compare the adult and pediatric patients with
cyclic vomiting syndrome. Since, different genetic backgrounds have been
proposed to be associated with difference in age of onset.
2. Major Compulsory Revision
Authors have done a great job comparing the pediatric vs. adult groups with CVS
in regard to demographics and disease characteristics. 3. More detailed
description of comparison between pediatric vs. adult patients with CVS in regard
to treatment and response is extremely important. Due to small number of
pediatric patients with CVS (n=29), the number of pediatric patients with CVS
might not be large enough in some categories to make the final conclusion of “no
differences in response to treatment between pediatric vs. adult patients with
CVS”.
4. Major Compulsory Revision
Authors discuss about the limitations of this study in detail. This study is one of
the largest studies characterizing adult vs. pediatric patients with CVS, but still
has relatively small number of pediatric patients. Considering the retrospective
nature of the study and missing documented data, this might be a significant
limiting factor in making clinical judgment on response to treatment. Details on
the number of collected data in treatment and response to treatment in pediatric
vs. adult patients with CVS is of great importance.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
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Reviewer's report
Title:Cyclic Vomiting Syndrome (CVS): is there a difference based on onset;
pediatric vs. adult?
Version: 1Date:19 January 2012
Reviewer: Tuba Esfandyari
Reviewer's report:
1. This is an interesting study to compare the adult and pediatric patients with
cyclic vomiting syndrome. Since, different genetic backgrounds have been
proposed to be associated with difference in age of onset.
2. Major Compulsory Revision
Authors have done a great job comparing the pediatric vs. adult groups with CVS
in regard to demographics and disease characteristics. 3. More detailed
description of comparison between pediatric vs. adult patients with CVS in regard
to treatment and response is extremely important. Due to small number of
pediatric patients with CVS (n=29), the number of pediatric patients with CVS
might not be large enough in some categories to make the final conclusion of “no
differences in response to treatment between pediatric vs. adult patients with
CVS”.
4. Major Compulsory Revision
Authors discuss about the limitations of this study in detail. This study is one of
the largest studies characterizing adult vs. pediatric patients with CVS, but still
has relatively small number of pediatric patients. Considering the retrospective
nature of the study and missing documented data, this might be a significant
limiting factor in making clinical judgment on response to treatment. Details on
the number of collected data in treatment and response to treatment in pediatric
vs. adult patients with CVS is of great importance.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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