Title: Combined use of CDAI and blood indices for assessing endoscopic activity in ileocolic
Crohn’s disease
Version: 1 Date: 04 Jun 2023
Reviewer's report:
I am very pleased to have had the opportunity to review this manuscript.
This study shows that evaluating a comprehensive index using clinical activity and peripheral
blood markers used in clinical practice can serve as a substitute for the endoscopic assessment
of CD activity. This manuscript may need the following revisions:
Major
Introduction
#Although the authors list blood, stool, urine and colonic tissue as biomarkers for CD, their
explanation is insufficient (Page 5, Line 102). Please add explanation and citation.
Results
#In this study, analysis of leukocyte differentiation is also performed. Neutrophils in particular
are affected by immunosuppression, can authors describe medication at enrollment?
Discussion
#In this study, the ratio of PLT to lymphocytes percentage was shown to be a factor that reflects
endoscopic activity. Although it is shown as a statistical analysis result, by what mechanism is
the lymphocyte percentage affected in CD activity?
#Did the ROC analysis of CRP and comprehensive index show a significant difference?
Comprehensive index seems to be complicated in scoring. Considering this complexity, isn't it
enough to evaluate only with CRP?
Minor
#Add an explanation of HB that first appeared (Page 12, Line 222)
Title: Combined use of CDAI and blood indices for assessing endoscopic activity in ileocolic
Crohn’s disease
Version: 1 Date: 04 Jun 2023
Reviewer's report:
I am very pleased to have had the opportunity to review this manuscript.
This study shows that evaluating a comprehensive index using clinical activity and peripheral
blood markers used in clinical practice can serve as a substitute for the endoscopic assessment
of CD activity. This manuscript may need the following revisions:
Major
Introduction
#Although the authors list blood, stool, urine and colonic tissue as biomarkers for CD, their
explanation is insufficient (Page 5, Line 102). Please add explanation and citation.
Results
#In this study, analysis of leukocyte differentiation is also performed. Neutrophils in particular
are affected by immunosuppression, can authors describe medication at enrollment?
Discussion
#In this study, the ratio of PLT to lymphocytes percentage was shown to be a factor that reflects
endoscopic activity. Although it is shown as a statistical analysis result, by what mechanism is
the lymphocyte percentage affected in CD activity?
#Did the ROC analysis of CRP and comprehensive index show a significant difference?
Comprehensive index seems to be complicated in scoring. Considering this complexity, isn't it
enough to evaluate only with CRP?
Minor
#Add an explanation of HB that first appeared (Page 12, Line 222)
Please review this paper.
user
Title: Combined use of CDAI and blood indices for assessing endoscopic activity in ileocolic
Crohn’s disease
Version: 1 Date: 04 Jun 2023
Reviewer's report:
I am very pleased to have had the opportunity to review this manuscript.
This study shows that evaluating a comprehensive index using clinical activity and peripheral
blood markers used in clinical practice can serve as a substitute for the endoscopic assessment
of CD activity. This manuscript may need the following revisions:
Major
Introduction
#Although the authors list blood, stool, urine and colonic tissue as biomarkers for CD, their
explanation is insufficient (Page 5, Line 102). Please add explanation and citation.
Results
#In this study, analysis of leukocyte differentiation is also performed. Neutrophils in particular
are affected by immunosuppression, can authors describe medication at enrollment?
Discussion
#In this study, the ratio of PLT to lymphocytes percentage was shown to be a factor that reflects
endoscopic activity. Although it is shown as a statistical analysis result, by what mechanism is
the lymphocyte percentage affected in CD activity?
#Did the ROC analysis of CRP and comprehensive index show a significant difference?
Comprehensive index seems to be complicated in scoring. Considering this complexity, isn't it
enough to evaluate only with CRP?
Minor
#Add an explanation of HB that first appeared (Page 12, Line 222)
assistant