Reviewer's report
Title:Association of RUNX 3 Promoter Methylation with Gastric Cancer: a
Pooled Study
Version: 3Date:25 April 2011
Reviewer: Kohji Miyazaki
Reviewer's report:
Basically, the authors made lots of mistakes in Figures and Tables of this
manuscript. At first, they selected 17 eligible papers finally. However, first two
papers were reported by the same author as shown in Figure 2. Furthermore,
different patient number was written in M+/M- of normal tissue, in which 7/93 in
1st Waki(a) 2003, 4/19 in 2nd Waki(a) 2003. Moreover, in Event column of Figure
2, M+/M- actually represents M+/total number. For instance, in report by Hiraki
(2010), M+/M- in cancer is 28/21, not 28/49, M+/M- in normal is 14/21, not 14/49.
Concerning these mistakes, 1082 patients (475/M+, 453/M-) should be
accounted in total number of cancer patients, however 1403 (475/M+, 928/M-)
was written in Table 1. As same in Figure 2, wrong numbers of patient were
plotted in Figure 3 and 4.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Reviewer's report
Title:Association of RUNX 3 Promoter Methylation with Gastric Cancer: a
Pooled Study
Version: 3Date:25 April 2011
Reviewer: Kohji Miyazaki
Reviewer's report:
Basically, the authors made lots of mistakes in Figures and Tables of this
manuscript. At first, they selected 17 eligible papers finally. However, first two
papers were reported by the same author as shown in Figure 2. Furthermore,
different patient number was written in M+/M- of normal tissue, in which 7/93 in
1st Waki(a) 2003, 4/19 in 2nd Waki(a) 2003. Moreover, in Event column of Figure
2, M+/M- actually represents M+/total number. For instance, in report by Hiraki
(2010), M+/M- in cancer is 28/21, not 28/49, M+/M- in normal is 14/21, not 14/49.
Concerning these mistakes, 1082 patients (475/M+, 453/M-) should be
accounted in total number of cancer patients, however 1403 (475/M+, 928/M-)
was written in Table 1. As same in Figure 2, wrong numbers of patient were
plotted in Figure 3 and 4.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Please review this paper.
user
Reviewer's report
Title:Association of RUNX 3 Promoter Methylation with Gastric Cancer: a
Pooled Study
Version: 3Date:25 April 2011
Reviewer: Kohji Miyazaki
Reviewer's report:
Basically, the authors made lots of mistakes in Figures and Tables of this
manuscript. At first, they selected 17 eligible papers finally. However, first two
papers were reported by the same author as shown in Figure 2. Furthermore,
different patient number was written in M+/M- of normal tissue, in which 7/93 in
1st Waki(a) 2003, 4/19 in 2nd Waki(a) 2003. Moreover, in Event column of Figure
2, M+/M- actually represents M+/total number. For instance, in report by Hiraki
(2010), M+/M- in cancer is 28/21, not 28/49, M+/M- in normal is 14/21, not 14/49.
Concerning these mistakes, 1082 patients (475/M+, 453/M-) should be
accounted in total number of cancer patients, however 1403 (475/M+, 928/M-)
was written in Table 1. As same in Figure 2, wrong numbers of patient were
plotted in Figure 3 and 4.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
assistant