Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 1 Date: 07 Sep 2024
Reviewer's report:
1. IT WAS STATED THAT POWER ANALYSIS WAS PERFORMED FOR THE STUDY
AND 150 PATIENTS WERE DETERMINED.
ACCORDING TO PATHOLOGY RESULTS, IT WAS STATED THAT ALL 150 PATIENTS
WERE DIAGNOSISED AS PERFORATED OR NONPERFORATED. IN SURGICAL
PRACTICE, IT IS NOT POSSIBLE FOR ALL 50 PATIENTS TO BE DIAGNOSED WITH
APPENDICITIS.
SOME PATIENTS ARE DIAGNOSED AS NEGATIVE APPENDICITIS. IN ACTUALLY,
THE NUMBER INCLUDED IN THE STUDY SHOULD BE MORE SO THAT THE
NUMBER OF PATIENTS DIAGNOSED WITH APPENDICITIS CAN BE REACHED.
IN THIS CASE, OUR REAL SAMPLE NUMBER SHOULD BE MORE OR THOSE WHO
WERE NOT PATHOLOGICALLY DIAGNOSISED WITH APPENDICITIS IN THE NON
PERFORATED PATIENT GROUP SHOULD BE SPECIFIED.
2. IN THE DISCUSSION SECTION, SIMILAR STUDIES WERE LISTED ONE BY ONE
AND THEIR RESULTS WERE EXPRESSED.
SCIENTIFIC EVALUATION OR COMPARISON WAS KEPT AWAY.
THE AUTHORS HAVE EXPRESSED THAT THEY HAVE SIMILAR RESULTS WITH
THEIR OWN STUDIES, BUT ALMOST ALL OF THE EXAMPLES THEY GAVE
CONSISTED OF AUTHORS WHO HAVE REACHED THE OPPOSITE CONCLUSIONS.
3. THE AUTHORS CLAIM THAT IF PERFORATION IS DETECTED, THIS SITUATION
WILL SHAPE THE INCISION CHOICE. I REGRET TO STATE THAT THIS CAN ONLY
BE A CLAIM. AS LONG AS FACTORS SUCH AS THE DEGREE OF PERFORATION,
PRESENCE OF PHLEGMON, AND EDEMA STATUS IN THE CECUMA ARE NOT
KNOWN, THE INCISION CHOICE MAY REMAIN ONLY AN INTENTION. 5HIAA
LEVELS DO NOT CONTRIBUTE TO ANY OF THESE ISSUES.
4. 5 HIAA IS A SUBJECT THAT HAS BEEN STUDIED IN THE LITERATURE, AND
MANY STUDIES WITH A LARGER NUMBER OF SAMPLES HAVE RESULTS THAT
ARE OPPOSITE TO WHAT THE AUTHORS CLAIMED. A CURRENT META-ANALYSIS
DATED 2023 (Arredondo Montero J, Bueso Asfura OE, Pérez Riveros BP, López Burgos
E, Rico Jiménez M. Diagnostic performance of urinary 5-Hydroxyindoleacetic Acid in acute
appendicitis: a systematic review and diagnostic test accuracy meta-analysis. Int J Colorectal
Dis. 2023 Nov 20;38(1):269. doi: 10.1007/s00384-023-04556-w.) stated that 5 HIAA was not
beneficial in complicated or noncomplicated acute appendicitis. The authors' results will be
meaningful only if they can provide scientific interpretation or evidence to the studies and such
meta-analyses that claim the opposite. Otherwise, they will be left with fewer cases compared to
the data in the literature. No opinion was put forward against other publications in the discussion
section.
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 1 Date: 07 Sep 2024
Reviewer's report:
1. IT WAS STATED THAT POWER ANALYSIS WAS PERFORMED FOR THE STUDY
AND 150 PATIENTS WERE DETERMINED.
ACCORDING TO PATHOLOGY RESULTS, IT WAS STATED THAT ALL 150 PATIENTS
WERE DIAGNOSISED AS PERFORATED OR NONPERFORATED. IN SURGICAL
PRACTICE, IT IS NOT POSSIBLE FOR ALL 50 PATIENTS TO BE DIAGNOSED WITH
APPENDICITIS.
SOME PATIENTS ARE DIAGNOSED AS NEGATIVE APPENDICITIS. IN ACTUALLY,
THE NUMBER INCLUDED IN THE STUDY SHOULD BE MORE SO THAT THE
NUMBER OF PATIENTS DIAGNOSED WITH APPENDICITIS CAN BE REACHED.
IN THIS CASE, OUR REAL SAMPLE NUMBER SHOULD BE MORE OR THOSE WHO
WERE NOT PATHOLOGICALLY DIAGNOSISED WITH APPENDICITIS IN THE NON
PERFORATED PATIENT GROUP SHOULD BE SPECIFIED.
2. IN THE DISCUSSION SECTION, SIMILAR STUDIES WERE LISTED ONE BY ONE
AND THEIR RESULTS WERE EXPRESSED.
SCIENTIFIC EVALUATION OR COMPARISON WAS KEPT AWAY.
THE AUTHORS HAVE EXPRESSED THAT THEY HAVE SIMILAR RESULTS WITH
THEIR OWN STUDIES, BUT ALMOST ALL OF THE EXAMPLES THEY GAVE
CONSISTED OF AUTHORS WHO HAVE REACHED THE OPPOSITE CONCLUSIONS.
3. THE AUTHORS CLAIM THAT IF PERFORATION IS DETECTED, THIS SITUATION
WILL SHAPE THE INCISION CHOICE. I REGRET TO STATE THAT THIS CAN ONLY
BE A CLAIM. AS LONG AS FACTORS SUCH AS THE DEGREE OF PERFORATION,
PRESENCE OF PHLEGMON, AND EDEMA STATUS IN THE CECUMA ARE NOT
KNOWN, THE INCISION CHOICE MAY REMAIN ONLY AN INTENTION. 5HIAA
LEVELS DO NOT CONTRIBUTE TO ANY OF THESE ISSUES.
4. 5 HIAA IS A SUBJECT THAT HAS BEEN STUDIED IN THE LITERATURE, AND
MANY STUDIES WITH A LARGER NUMBER OF SAMPLES HAVE RESULTS THAT
ARE OPPOSITE TO WHAT THE AUTHORS CLAIMED. A CURRENT META-ANALYSIS
DATED 2023 (Arredondo Montero J, Bueso Asfura OE, Pérez Riveros BP, López Burgos
E, Rico Jiménez M. Diagnostic performance of urinary 5-Hydroxyindoleacetic Acid in acute
appendicitis: a systematic review and diagnostic test accuracy meta-analysis. Int J Colorectal
Dis. 2023 Nov 20;38(1):269. doi: 10.1007/s00384-023-04556-w.) stated that 5 HIAA was not
beneficial in complicated or noncomplicated acute appendicitis. The authors' results will be
meaningful only if they can provide scientific interpretation or evidence to the studies and such
meta-analyses that claim the opposite. Otherwise, they will be left with fewer cases compared to
the data in the literature. No opinion was put forward against other publications in the discussion
section.
Please review this paper.
user
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 1 Date: 07 Sep 2024
Reviewer's report:
1. IT WAS STATED THAT POWER ANALYSIS WAS PERFORMED FOR THE STUDY
AND 150 PATIENTS WERE DETERMINED.
ACCORDING TO PATHOLOGY RESULTS, IT WAS STATED THAT ALL 150 PATIENTS
WERE DIAGNOSISED AS PERFORATED OR NONPERFORATED. IN SURGICAL
PRACTICE, IT IS NOT POSSIBLE FOR ALL 50 PATIENTS TO BE DIAGNOSED WITH
APPENDICITIS.
SOME PATIENTS ARE DIAGNOSED AS NEGATIVE APPENDICITIS. IN ACTUALLY,
THE NUMBER INCLUDED IN THE STUDY SHOULD BE MORE SO THAT THE
NUMBER OF PATIENTS DIAGNOSED WITH APPENDICITIS CAN BE REACHED.
IN THIS CASE, OUR REAL SAMPLE NUMBER SHOULD BE MORE OR THOSE WHO
WERE NOT PATHOLOGICALLY DIAGNOSISED WITH APPENDICITIS IN THE NON
PERFORATED PATIENT GROUP SHOULD BE SPECIFIED.
2. IN THE DISCUSSION SECTION, SIMILAR STUDIES WERE LISTED ONE BY ONE
AND THEIR RESULTS WERE EXPRESSED.
SCIENTIFIC EVALUATION OR COMPARISON WAS KEPT AWAY.
THE AUTHORS HAVE EXPRESSED THAT THEY HAVE SIMILAR RESULTS WITH
THEIR OWN STUDIES, BUT ALMOST ALL OF THE EXAMPLES THEY GAVE
CONSISTED OF AUTHORS WHO HAVE REACHED THE OPPOSITE CONCLUSIONS.
3. THE AUTHORS CLAIM THAT IF PERFORATION IS DETECTED, THIS SITUATION
WILL SHAPE THE INCISION CHOICE. I REGRET TO STATE THAT THIS CAN ONLY
BE A CLAIM. AS LONG AS FACTORS SUCH AS THE DEGREE OF PERFORATION,
PRESENCE OF PHLEGMON, AND EDEMA STATUS IN THE CECUMA ARE NOT
KNOWN, THE INCISION CHOICE MAY REMAIN ONLY AN INTENTION. 5HIAA
LEVELS DO NOT CONTRIBUTE TO ANY OF THESE ISSUES.
4. 5 HIAA IS A SUBJECT THAT HAS BEEN STUDIED IN THE LITERATURE, AND
MANY STUDIES WITH A LARGER NUMBER OF SAMPLES HAVE RESULTS THAT
ARE OPPOSITE TO WHAT THE AUTHORS CLAIMED. A CURRENT META-ANALYSIS
DATED 2023 (Arredondo Montero J, Bueso Asfura OE, Pérez Riveros BP, López Burgos
E, Rico Jiménez M. Diagnostic performance of urinary 5-Hydroxyindoleacetic Acid in acute
appendicitis: a systematic review and diagnostic test accuracy meta-analysis. Int J Colorectal
Dis. 2023 Nov 20;38(1):269. doi: 10.1007/s00384-023-04556-w.) stated that 5 HIAA was not
beneficial in complicated or noncomplicated acute appendicitis. The authors' results will be
meaningful only if they can provide scientific interpretation or evidence to the studies and such
meta-analyses that claim the opposite. Otherwise, they will be left with fewer cases compared to
the data in the literature. No opinion was put forward against other publications in the discussion
section.
assistant