Reviewer's report
Title:Positive regulatory effects of perioperative probiotic treatment on
postoperative liver complications after colorectal liver metastases surgery: a
double-center and double-blind randomized clinical trial
Version:2Date:6 December 2014
Reviewer: Alexandre Darani
Reviewer's report:
Minors essential revisions:
1. Abstract background: note, postoperative intestinal infection is still common
2. Abstract aim: Zonulin needs a small introduction like: zonulin, a marker of
intestinal permeability,...
3. Line 56: to evaluate the impact on the liver...
4. Line 58-61: grammatical review
5. Line 62: ? Paralyzed ??
6. Line 100: infectious complication need to be avoided, but you cannot say that
antibiotics are not the best choice to treat them
7. Line 104: ... Bacteria may be expands?? Need grammatical correction
8. Line 126: our previous study...
9. Line 127: transmucosal permeation or permeability?
10. Line 332 to 334: this needs to be correlated with the amount of liver
resection. Level of AST/ALT will vary considerably between massive reaction vs
1 single small border metastasis. Are the 2 groups comparable on this?
11. Line 357-360: does the liver resection not increase by itself directly the
zonula in lever (or indirectly)? You use the term "liver barrier". What do you mean
exactly? You cannot assume that it is similar than the Intestinal TJ junction. This
needs more clarification
12. Line 359: We mean... Another verb would be more appropriate
13. Line 501: despite... Grammatical review
14. Line 582: that could be the first limitation
15: line 571: disable? Grammatical review
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Positive regulatory effects of perioperative probiotic treatment on
postoperative liver complications after colorectal liver metastases surgery: a
double-center and double-blind randomized clinical trial
Version:2Date:6 December 2014
Reviewer: Alexandre Darani
Reviewer's report:
Minors essential revisions:
1. Abstract background: note, postoperative intestinal infection is still common
2. Abstract aim: Zonulin needs a small introduction like: zonulin, a marker of
intestinal permeability,...
3. Line 56: to evaluate the impact on the liver...
4. Line 58-61: grammatical review
5. Line 62: ? Paralyzed ??
6. Line 100: infectious complication need to be avoided, but you cannot say that
antibiotics are not the best choice to treat them
7. Line 104: ... Bacteria may be expands?? Need grammatical correction
8. Line 126: our previous study...
9. Line 127: transmucosal permeation or permeability?
10. Line 332 to 334: this needs to be correlated with the amount of liver
resection. Level of AST/ALT will vary considerably between massive reaction vs
1 single small border metastasis. Are the 2 groups comparable on this?
11. Line 357-360: does the liver resection not increase by itself directly the
zonula in lever (or indirectly)? You use the term "liver barrier". What do you mean
exactly? You cannot assume that it is similar than the Intestinal TJ junction. This
needs more clarification
12. Line 359: We mean... Another verb would be more appropriate
13. Line 501: despite... Grammatical review
14. Line 582: that could be the first limitation
15: line 571: disable? Grammatical review
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Positive regulatory effects of perioperative probiotic treatment on
postoperative liver complications after colorectal liver metastases surgery: a
double-center and double-blind randomized clinical trial
Version:2Date:6 December 2014
Reviewer: Alexandre Darani
Reviewer's report:
Minors essential revisions:
1. Abstract background: note, postoperative intestinal infection is still common
2. Abstract aim: Zonulin needs a small introduction like: zonulin, a marker of
intestinal permeability,...
3. Line 56: to evaluate the impact on the liver...
4. Line 58-61: grammatical review
5. Line 62: ? Paralyzed ??
6. Line 100: infectious complication need to be avoided, but you cannot say that
antibiotics are not the best choice to treat them
7. Line 104: ... Bacteria may be expands?? Need grammatical correction
8. Line 126: our previous study...
9. Line 127: transmucosal permeation or permeability?
10. Line 332 to 334: this needs to be correlated with the amount of liver
resection. Level of AST/ALT will vary considerably between massive reaction vs
1 single small border metastasis. Are the 2 groups comparable on this?
11. Line 357-360: does the liver resection not increase by itself directly the
zonula in lever (or indirectly)? You use the term "liver barrier". What do you mean
exactly? You cannot assume that it is similar than the Intestinal TJ junction. This
needs more clarification
12. Line 359: We mean... Another verb would be more appropriate
13. Line 501: despite... Grammatical review
14. Line 582: that could be the first limitation
15: line 571: disable? Grammatical review
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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