Title: Serum O-glycosylated hepatitis B surface antigen levels in patients with chronic hepatitis
B during nucleos(t)ide analog therapy
Version: 2 Date: 25 Apr 2022
Reviewer's report:
This study aimed to evaluate serum O-glycosylated HBsAg levels in patients with chronic
hepatitis B treated with nucleostide analogs. On the whole, this article was well revised.
However, the language should be seriously revised. Some comments are also listed as follows.
Comment 1: The authors should specify the treatment indications for the subjects in the article
rather than only cite “The guidelines of the Japanese Society of Hepatology” in Line 89.
Comment 2: The authors should check the data carefully. In Table 1, the percentages of Males
were calculated incorrectly in the HBeAg positive column and HBeAg negative column. In
addition, the authors should adjust the format of the Table 1 to make it look fine.
Comment 3: The authors should check the words in the manuscript carefully. For example,
“patent” should be revised as “patient” in Line 263.
Comment 4: The authors have not yet answered whether this study has potential application in
predicting HBsAg seroclearance.
Title: Serum O-glycosylated hepatitis B surface antigen levels in patients with chronic hepatitis
B during nucleos(t)ide analog therapy
Version: 2 Date: 25 Apr 2022
Reviewer's report:
This study aimed to evaluate serum O-glycosylated HBsAg levels in patients with chronic
hepatitis B treated with nucleostide analogs. On the whole, this article was well revised.
However, the language should be seriously revised. Some comments are also listed as follows.
Comment 1: The authors should specify the treatment indications for the subjects in the article
rather than only cite “The guidelines of the Japanese Society of Hepatology” in Line 89.
Comment 2: The authors should check the data carefully. In Table 1, the percentages of Males
were calculated incorrectly in the HBeAg positive column and HBeAg negative column. In
addition, the authors should adjust the format of the Table 1 to make it look fine.
Comment 3: The authors should check the words in the manuscript carefully. For example,
“patent” should be revised as “patient” in Line 263.
Comment 4: The authors have not yet answered whether this study has potential application in
predicting HBsAg seroclearance.
Please review this paper.
user
Title: Serum O-glycosylated hepatitis B surface antigen levels in patients with chronic hepatitis
B during nucleos(t)ide analog therapy
Version: 2 Date: 25 Apr 2022
Reviewer's report:
This study aimed to evaluate serum O-glycosylated HBsAg levels in patients with chronic
hepatitis B treated with nucleostide analogs. On the whole, this article was well revised.
However, the language should be seriously revised. Some comments are also listed as follows.
Comment 1: The authors should specify the treatment indications for the subjects in the article
rather than only cite “The guidelines of the Japanese Society of Hepatology” in Line 89.
Comment 2: The authors should check the data carefully. In Table 1, the percentages of Males
were calculated incorrectly in the HBeAg positive column and HBeAg negative column. In
addition, the authors should adjust the format of the Table 1 to make it look fine.
Comment 3: The authors should check the words in the manuscript carefully. For example,
“patent” should be revised as “patient” in Line 263.
Comment 4: The authors have not yet answered whether this study has potential application in
predicting HBsAg seroclearance.
assistant