Title: Chronic Gastritis May Predict Risk of Cerebral Small Vessel Disease
Version: 1 Date: 01 Oct 2023
Reviewer:  Kazuo Yamashiro
Reviewer's report:
In this study, Wei C, et al. investigated the association between chronic gastritis and cerebral
small vessel disease (CSVD) in patients underwent gastroscopy. The authors reported that
chronic atrophic gastritis was associated with the presence of CSVD.
Comments
1. In the introduction, the authors mention that chronic gastritis caused by helicobacter pylori
(HP) infection is associated with an increased risk of ischemic stroke. Was chronic atrophic
gastritis associated with HP in this study? Please add the discussion.
2. Prevalence of hyperlipidemia was lower in patients with CSVD than those without. The
authors describe that this may be related to the intake of lipid-lowering drugs. The vascular
risk factors such as hypertension, diabetes, and dyslipidemia are usually defined as the use of
medications for these conditions or based on elevated blood pressure, glucose, and cholesterol
levels. The risk factor definition should be described more clearly in the methods, and
appropriate assessment of risk factors is needed.
3. What is the rationale of selecting variables for multivariate analysis? Factors showing
significant difference in Table 1 and atrial fibrillation (p=0.092) were selected, but presence of
fecal occult blood (p=0.045) and HP infection (p=0.088) were not. Please explain how to select
variables incorporated in multivariate analysis in the statistical analysis.
Title: Chronic Gastritis May Predict Risk of Cerebral Small Vessel Disease
Version: 1 Date: 01 Oct 2023
Reviewer:  Kazuo Yamashiro
Reviewer's report:
In this study, Wei C, et al. investigated the association between chronic gastritis and cerebral
small vessel disease (CSVD) in patients underwent gastroscopy. The authors reported that
chronic atrophic gastritis was associated with the presence of CSVD.
Comments
1. In the introduction, the authors mention that chronic gastritis caused by helicobacter pylori
(HP) infection is associated with an increased risk of ischemic stroke. Was chronic atrophic
gastritis associated with HP in this study? Please add the discussion.
2. Prevalence of hyperlipidemia was lower in patients with CSVD than those without. The
authors describe that this may be related to the intake of lipid-lowering drugs. The vascular
risk factors such as hypertension, diabetes, and dyslipidemia are usually defined as the use of
medications for these conditions or based on elevated blood pressure, glucose, and cholesterol
levels. The risk factor definition should be described more clearly in the methods, and
appropriate assessment of risk factors is needed.
3. What is the rationale of selecting variables for multivariate analysis? Factors showing
significant difference in Table 1 and atrial fibrillation (p=0.092) were selected, but presence of
fecal occult blood (p=0.045) and HP infection (p=0.088) were not. Please explain how to select
variables incorporated in multivariate analysis in the statistical analysis.
Please review this paper.
user
Title: Chronic Gastritis May Predict Risk of Cerebral Small Vessel Disease
Version: 1 Date: 01 Oct 2023
Reviewer:  Kazuo Yamashiro
Reviewer's report:
In this study, Wei C, et al. investigated the association between chronic gastritis and cerebral
small vessel disease (CSVD) in patients underwent gastroscopy. The authors reported that
chronic atrophic gastritis was associated with the presence of CSVD.
Comments
1. In the introduction, the authors mention that chronic gastritis caused by helicobacter pylori
(HP) infection is associated with an increased risk of ischemic stroke. Was chronic atrophic
gastritis associated with HP in this study? Please add the discussion.
2. Prevalence of hyperlipidemia was lower in patients with CSVD than those without. The
authors describe that this may be related to the intake of lipid-lowering drugs. The vascular
risk factors such as hypertension, diabetes, and dyslipidemia are usually defined as the use of
medications for these conditions or based on elevated blood pressure, glucose, and cholesterol
levels. The risk factor definition should be described more clearly in the methods, and
appropriate assessment of risk factors is needed.
3. What is the rationale of selecting variables for multivariate analysis? Factors showing
significant difference in Table 1 and atrial fibrillation (p=0.092) were selected, but presence of
fecal occult blood (p=0.045) and HP infection (p=0.088) were not. Please explain how to select
variables incorporated in multivariate analysis in the statistical analysis.
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