Title: Predictive Model for Identification of Gangrenous or Perforated Appendicitis in Adults:
A Multicenter Retrospective Study
Version: 7 Date: 21 Aug 2024
Reviewer:  Sushila Kumar Pattanaik
Reviewer's report:
Thanks for the response.
I could not find the detailed explanation of the reasons why parameters like NLR, fibrinogen,
PCT, total bilirubin were excluded from statistical analysis in page 19, lines 6-9. After analysis of
clinical characteristics, the text shifts to incorporation of seven variables only. Your explanation
to the reviewer in the response to reviewers during revision 1 was correct, which goes like this,
"parameters such as fibrinogen (Fg) were excluded due to their lack of statistical significance
in the univariate analysis. Similarly, factors like neutrophil-to-lymphocyte ratio (NLR) and
procalcitonin (PCT) were not included in the final model due to their lack of statistical
significance in the multivariate analysis." This concept may be added under discussion section,
after analysis of clinical characteristics, for a clarity to the readers. Rest are fine.
Title: Predictive Model for Identification of Gangrenous or Perforated Appendicitis in Adults:
A Multicenter Retrospective Study
Version: 7 Date: 21 Aug 2024
Reviewer:  Sushila Kumar Pattanaik
Reviewer's report:
Thanks for the response.
I could not find the detailed explanation of the reasons why parameters like NLR, fibrinogen,
PCT, total bilirubin were excluded from statistical analysis in page 19, lines 6-9. After analysis of
clinical characteristics, the text shifts to incorporation of seven variables only. Your explanation
to the reviewer in the response to reviewers during revision 1 was correct, which goes like this,
"parameters such as fibrinogen (Fg) were excluded due to their lack of statistical significance
in the univariate analysis. Similarly, factors like neutrophil-to-lymphocyte ratio (NLR) and
procalcitonin (PCT) were not included in the final model due to their lack of statistical
significance in the multivariate analysis." This concept may be added under discussion section,
after analysis of clinical characteristics, for a clarity to the readers. Rest are fine.
Please review this paper.
user
Title: Predictive Model for Identification of Gangrenous or Perforated Appendicitis in Adults:
A Multicenter Retrospective Study
Version: 7 Date: 21 Aug 2024
Reviewer:  Sushila Kumar Pattanaik
Reviewer's report:
Thanks for the response.
I could not find the detailed explanation of the reasons why parameters like NLR, fibrinogen,
PCT, total bilirubin were excluded from statistical analysis in page 19, lines 6-9. After analysis of
clinical characteristics, the text shifts to incorporation of seven variables only. Your explanation
to the reviewer in the response to reviewers during revision 1 was correct, which goes like this,
"parameters such as fibrinogen (Fg) were excluded due to their lack of statistical significance
in the univariate analysis. Similarly, factors like neutrophil-to-lymphocyte ratio (NLR) and
procalcitonin (PCT) were not included in the final model due to their lack of statistical
significance in the multivariate analysis." This concept may be added under discussion section,
after analysis of clinical characteristics, for a clarity to the readers. Rest are fine.
assistant