Title: Functional outcomes of patients with short-segment Hirschsprung disease after transanal
endorectal pull-through
Version: 1 Date: 25 Jan 2021
Reviewer:  Iacopo Giani
Reviewer's report:
INTRODUCTION
In the introduction, reference is made to transabdominal pull-through but this is not used as a
term of comparison in a clinical comparison in the context of the study.
METHODS and RESULTS
The study does not indicate the follow-up to which patients are re-evaluated, the pre-operative
status in functional terms (bowel movement) is not clear and even subsequently in the results
if between a first follow up and perhaps a second longer follow up differences. In the absence
of the pre-operative data in functional terms, the possible progonostic function of this data on
the intervention is also missing.
The study is well conducted, the data collection well done and I would speak more of a
prospective maintained database as a reward for those who have prospectively collected data
over the years (unfortunately remaining a retrospective work). The statistical analysis I would
say is very well conducted.
It could be useful to include in the study a small flowchart on the measures adopted for a
successful intervention in terms of complications and in functional terms, to be discussed in the
discussion
In summary I think the study is interesting and well written, if it were possible to have the data
requested in my comment as well as the flowchart I believe it would acquire in terminality. Well
done!
Title: Functional outcomes of patients with short-segment Hirschsprung disease after transanal
endorectal pull-through
Version: 1 Date: 25 Jan 2021
Reviewer:  Iacopo Giani
Reviewer's report:
INTRODUCTION
In the introduction, reference is made to transabdominal pull-through but this is not used as a
term of comparison in a clinical comparison in the context of the study.
METHODS and RESULTS
The study does not indicate the follow-up to which patients are re-evaluated, the pre-operative
status in functional terms (bowel movement) is not clear and even subsequently in the results
if between a first follow up and perhaps a second longer follow up differences. In the absence
of the pre-operative data in functional terms, the possible progonostic function of this data on
the intervention is also missing.
The study is well conducted, the data collection well done and I would speak more of a
prospective maintained database as a reward for those who have prospectively collected data
over the years (unfortunately remaining a retrospective work). The statistical analysis I would
say is very well conducted.
It could be useful to include in the study a small flowchart on the measures adopted for a
successful intervention in terms of complications and in functional terms, to be discussed in the
discussion
In summary I think the study is interesting and well written, if it were possible to have the data
requested in my comment as well as the flowchart I believe it would acquire in terminality. Well
done!
Please review this paper.
user
Title: Functional outcomes of patients with short-segment Hirschsprung disease after transanal
endorectal pull-through
Version: 1 Date: 25 Jan 2021
Reviewer:  Iacopo Giani
Reviewer's report:
INTRODUCTION
In the introduction, reference is made to transabdominal pull-through but this is not used as a
term of comparison in a clinical comparison in the context of the study.
METHODS and RESULTS
The study does not indicate the follow-up to which patients are re-evaluated, the pre-operative
status in functional terms (bowel movement) is not clear and even subsequently in the results
if between a first follow up and perhaps a second longer follow up differences. In the absence
of the pre-operative data in functional terms, the possible progonostic function of this data on
the intervention is also missing.
The study is well conducted, the data collection well done and I would speak more of a
prospective maintained database as a reward for those who have prospectively collected data
over the years (unfortunately remaining a retrospective work). The statistical analysis I would
say is very well conducted.
It could be useful to include in the study a small flowchart on the measures adopted for a
successful intervention in terms of complications and in functional terms, to be discussed in the
discussion
In summary I think the study is interesting and well written, if it were possible to have the data
requested in my comment as well as the flowchart I believe it would acquire in terminality. Well
done!
assistant