Title: The association between dietary total antioxidant capacity and odds and severity of
irritable bowel syndrome among Iranian adults: a cross-sectional study
Version: 1 Date: 31 Jul 2022
Reviewer's report:
The manuscript entitled “The association between dietary total antioxidant capacity and odds
and severity of irritable bowel syndrome among Iranian adults: a cross-sectional study” is well-
design and meaningful topic. However, some revisions and clarifications especially in Abstract,
Introduction, Methods, and Results section should be considered.
Major revision
1. As a general comment, there are some writing and grammatical errors in the text, and having
an editor read through the paper would be useful to take care of this.
2. In the Results section of the Abstract and Main text, you did not report the prevalence of IBS
and its subtypes in the participants of this study!
3. Please use term "tertile" instead of "category" in all parts of the Manuscript. Using the word
"category" means that you have arbitrarily classified the participants based on dTAC.
4. Considering that your study is an epidemiological study that examines the role of a type
of dietary index (dTAC) in predicting the risk of a chronic disease (IBS), therefore, the
present study is a study in the field of prevention of chronic diseases, not in the treatment
and management of a chronic disease. In the Manuscript, especially in the Introduction and
Discussion sections, you should not discuss the role of nutritional factors in the treatment or
management of IBS, and there is no need to provide the results of studies conducted on the
nutritional management of IBS. Please focus only on studies examining the role of nutrition in
predicting IBS risk. For example, in the second paragraph of the Introduction section, lines 12
to 16, it is discussed on the nutritional management and treatment of the IBS.
5. Some sentences in the Introduction section are very general and do not have a clear
explanation. Please explain them in more detail. For example, in the sentence" Accordingly,
several studies have been conducted on the associations between dTAC and chronic disease ", at
least mention the names of chronic diseases. And dTAC has the ability to prevent these chronic
diseases according to the results of these studies?
6. Which chronic diseases and which medications could have a confounding role in your study?
You must specify
7. Can marital status be a confounding variable for your study analyses? Please explain.
8. Why did you perform sensitivity analysis based on gender and body mass index? Did you
check the interaction of these variables with total oxidant capacity in relation to the outcome of
the study? Table 1 does not show any significant difference regarding these two variables across
tertiles of dTAC! Please explain.
Title: The association between dietary total antioxidant capacity and odds and severity of
irritable bowel syndrome among Iranian adults: a cross-sectional study
Version: 1 Date: 31 Jul 2022
Reviewer's report:
The manuscript entitled “The association between dietary total antioxidant capacity and odds
and severity of irritable bowel syndrome among Iranian adults: a cross-sectional study” is well-
design and meaningful topic. However, some revisions and clarifications especially in Abstract,
Introduction, Methods, and Results section should be considered.
Major revision
1. As a general comment, there are some writing and grammatical errors in the text, and having
an editor read through the paper would be useful to take care of this.
2. In the Results section of the Abstract and Main text, you did not report the prevalence of IBS
and its subtypes in the participants of this study!
3. Please use term "tertile" instead of "category" in all parts of the Manuscript. Using the word
"category" means that you have arbitrarily classified the participants based on dTAC.
4. Considering that your study is an epidemiological study that examines the role of a type
of dietary index (dTAC) in predicting the risk of a chronic disease (IBS), therefore, the
present study is a study in the field of prevention of chronic diseases, not in the treatment
and management of a chronic disease. In the Manuscript, especially in the Introduction and
Discussion sections, you should not discuss the role of nutritional factors in the treatment or
management of IBS, and there is no need to provide the results of studies conducted on the
nutritional management of IBS. Please focus only on studies examining the role of nutrition in
predicting IBS risk. For example, in the second paragraph of the Introduction section, lines 12
to 16, it is discussed on the nutritional management and treatment of the IBS.
5. Some sentences in the Introduction section are very general and do not have a clear
explanation. Please explain them in more detail. For example, in the sentence" Accordingly,
several studies have been conducted on the associations between dTAC and chronic disease ", at
least mention the names of chronic diseases. And dTAC has the ability to prevent these chronic
diseases according to the results of these studies?
6. Which chronic diseases and which medications could have a confounding role in your study?
You must specify
7. Can marital status be a confounding variable for your study analyses? Please explain.
8. Why did you perform sensitivity analysis based on gender and body mass index? Did you
check the interaction of these variables with total oxidant capacity in relation to the outcome of
the study? Table 1 does not show any significant difference regarding these two variables across
tertiles of dTAC! Please explain.
Please review this paper.
user
Title: The association between dietary total antioxidant capacity and odds and severity of
irritable bowel syndrome among Iranian adults: a cross-sectional study
Version: 1 Date: 31 Jul 2022
Reviewer's report:
The manuscript entitled “The association between dietary total antioxidant capacity and odds
and severity of irritable bowel syndrome among Iranian adults: a cross-sectional study” is well-
design and meaningful topic. However, some revisions and clarifications especially in Abstract,
Introduction, Methods, and Results section should be considered.
Major revision
1. As a general comment, there are some writing and grammatical errors in the text, and having
an editor read through the paper would be useful to take care of this.
2. In the Results section of the Abstract and Main text, you did not report the prevalence of IBS
and its subtypes in the participants of this study!
3. Please use term "tertile" instead of "category" in all parts of the Manuscript. Using the word
"category" means that you have arbitrarily classified the participants based on dTAC.
4. Considering that your study is an epidemiological study that examines the role of a type
of dietary index (dTAC) in predicting the risk of a chronic disease (IBS), therefore, the
present study is a study in the field of prevention of chronic diseases, not in the treatment
and management of a chronic disease. In the Manuscript, especially in the Introduction and
Discussion sections, you should not discuss the role of nutritional factors in the treatment or
management of IBS, and there is no need to provide the results of studies conducted on the
nutritional management of IBS. Please focus only on studies examining the role of nutrition in
predicting IBS risk. For example, in the second paragraph of the Introduction section, lines 12
to 16, it is discussed on the nutritional management and treatment of the IBS.
5. Some sentences in the Introduction section are very general and do not have a clear
explanation. Please explain them in more detail. For example, in the sentence" Accordingly,
several studies have been conducted on the associations between dTAC and chronic disease ", at
least mention the names of chronic diseases. And dTAC has the ability to prevent these chronic
diseases according to the results of these studies?
6. Which chronic diseases and which medications could have a confounding role in your study?
You must specify
7. Can marital status be a confounding variable for your study analyses? Please explain.
8. Why did you perform sensitivity analysis based on gender and body mass index? Did you
check the interaction of these variables with total oxidant capacity in relation to the outcome of
the study? Table 1 does not show any significant difference regarding these two variables across
tertiles of dTAC! Please explain.
assistant