Title: Effectiveness of eradication therapy for Helicobacter pylori infection in Africa: A
systematic review and meta-analysis
Version: 0 Date: 18 Nov 2022
Reviewer:  Hong Cheng
Reviewer's report:
Helicobacter pylori infection is associated with a variety of upper gastrointestinal diseases.
Eradication of H. pylori can reduce the risk of gastric cancer. Antibiotic resistance is an important
reason for eradication treatment failure. The authors investigated the H. pylori eradication
effectiveness in Africa using the best available evidence from databases. They analyzed the
cumulative eradication rate for Africa and identified factors associated with eradication. They
thought eradication studies in Africa are so rare that more research must be promoted.
There are some problems:
1 It is recommended to add eradication rate items in Table 2.
2 The research time span included in this analysis and research is relatively large. From 1992 to
2020, the impact of time on the research results should be considered when analyzing the results
of these studies. It is suggested to add relevant contents in the discussion section.
3 This study found that the eradication rate was different with different detection methods. What
are the possible reasons?
4 Please check whether the eradication rates of different regimens in Table 3 are correct. It is
suggested to increase the total number of patients and the number of eradicated cases for each
eradication rate item in Table 3.
Title: Effectiveness of eradication therapy for Helicobacter pylori infection in Africa: A
systematic review and meta-analysis
Version: 0 Date: 18 Nov 2022
Reviewer:  Hong Cheng
Reviewer's report:
Helicobacter pylori infection is associated with a variety of upper gastrointestinal diseases.
Eradication of H. pylori can reduce the risk of gastric cancer. Antibiotic resistance is an important
reason for eradication treatment failure. The authors investigated the H. pylori eradication
effectiveness in Africa using the best available evidence from databases. They analyzed the
cumulative eradication rate for Africa and identified factors associated with eradication. They
thought eradication studies in Africa are so rare that more research must be promoted.
There are some problems:
1 It is recommended to add eradication rate items in Table 2.
2 The research time span included in this analysis and research is relatively large. From 1992 to
2020, the impact of time on the research results should be considered when analyzing the results
of these studies. It is suggested to add relevant contents in the discussion section.
3 This study found that the eradication rate was different with different detection methods. What
are the possible reasons?
4 Please check whether the eradication rates of different regimens in Table 3 are correct. It is
suggested to increase the total number of patients and the number of eradicated cases for each
eradication rate item in Table 3.
Please review this paper.
user
Title: Effectiveness of eradication therapy for Helicobacter pylori infection in Africa: A
systematic review and meta-analysis
Version: 0 Date: 18 Nov 2022
Reviewer:  Hong Cheng
Reviewer's report:
Helicobacter pylori infection is associated with a variety of upper gastrointestinal diseases.
Eradication of H. pylori can reduce the risk of gastric cancer. Antibiotic resistance is an important
reason for eradication treatment failure. The authors investigated the H. pylori eradication
effectiveness in Africa using the best available evidence from databases. They analyzed the
cumulative eradication rate for Africa and identified factors associated with eradication. They
thought eradication studies in Africa are so rare that more research must be promoted.
There are some problems:
1 It is recommended to add eradication rate items in Table 2.
2 The research time span included in this analysis and research is relatively large. From 1992 to
2020, the impact of time on the research results should be considered when analyzing the results
of these studies. It is suggested to add relevant contents in the discussion section.
3 This study found that the eradication rate was different with different detection methods. What
are the possible reasons?
4 Please check whether the eradication rates of different regimens in Table 3 are correct. It is
suggested to increase the total number of patients and the number of eradicated cases for each
eradication rate item in Table 3.
assistant