Title: A risk prediction model for nausea and vomiting after TACE : a cross-sectional study
Version: 1 Date: 11 Nov 2024
Reviewer's report:
Overall this is an interesting study and I think it is important to determine risk factors in order to
better help alleviate symptoms for patients.  Below are thoughts and comments to help improve
the delivery of the content determined.
Abstract – This is a relevant topic.  To say it has good clinical efficacy may be a strength at this
point and would not include this within the abstract
Intro – need to include a source for the statement “TACE should be performed along an extended
vascular route in order to achieve the benefits of reducing local tumor burden, preventing
postoperative recurrence, and improving overall survival rates”
Paragraph 3 needs to be streamlined and unsure if we need to describe systemic chemotherapy
passing through the venous blood, too simplistic.
Typo “Therefore, considering the hazard of nausea and vomiting after TACE, his study
integrated personal”
Methods
Please describe ‘severe complications’ a bit more clearly
Perhaps a graph describing patient selection would help clarify the methods
The time frame of the patients symptoms are not clear
Was there a difference between nausea, vomiting and both?
Results
Vomiting is misspelled several times in this section including in table 1
Please describe nausea and vomiting separately, they can be very different symptoms or describe
it as nausea and/or vomiting
Typo, evaluation is listed 2 times : Accuracy evaluation evaluation of the risk model
Discussion
Sections 1 and 2: These sections are not really helpful and I’m unsure of its importance to what
was actually studied. These seem more like introduction paragraphs.  Somehow need to bring
back that these risks lead to more nausea/vomiting.
The 4 grades of side effects to chemo medications needs to be put in the methods when stating
why grade >2 was chosen
The discussion should highlight more of the risk factors.
Nursing implications
-Are you suggesting this questionnaire should be used clinically?  Or to know the top predictors
in order to best take care of patients/
Conclusion -  the term ‘most’ would not be appropriate given it was only 32%.  I would use
the term a third only here.
Title: A risk prediction model for nausea and vomiting after TACE : a cross-sectional study
Version: 1 Date: 11 Nov 2024
Reviewer's report:
Overall this is an interesting study and I think it is important to determine risk factors in order to
better help alleviate symptoms for patients.  Below are thoughts and comments to help improve
the delivery of the content determined.
Abstract – This is a relevant topic.  To say it has good clinical efficacy may be a strength at this
point and would not include this within the abstract
Intro – need to include a source for the statement “TACE should be performed along an extended
vascular route in order to achieve the benefits of reducing local tumor burden, preventing
postoperative recurrence, and improving overall survival rates”
Paragraph 3 needs to be streamlined and unsure if we need to describe systemic chemotherapy
passing through the venous blood, too simplistic.
Typo “Therefore, considering the hazard of nausea and vomiting after TACE, his study
integrated personal”
Methods
Please describe ‘severe complications’ a bit more clearly
Perhaps a graph describing patient selection would help clarify the methods
The time frame of the patients symptoms are not clear
Was there a difference between nausea, vomiting and both?
Results
Vomiting is misspelled several times in this section including in table 1
Please describe nausea and vomiting separately, they can be very different symptoms or describe
it as nausea and/or vomiting
Typo, evaluation is listed 2 times : Accuracy evaluation evaluation of the risk model
Discussion
Sections 1 and 2: These sections are not really helpful and I’m unsure of its importance to what
was actually studied. These seem more like introduction paragraphs.  Somehow need to bring
back that these risks lead to more nausea/vomiting.
The 4 grades of side effects to chemo medications needs to be put in the methods when stating
why grade >2 was chosen
The discussion should highlight more of the risk factors.
Nursing implications
-Are you suggesting this questionnaire should be used clinically?  Or to know the top predictors
in order to best take care of patients/
Conclusion -  the term ‘most’ would not be appropriate given it was only 32%.  I would use
the term a third only here.
Please review this paper.
user
Title: A risk prediction model for nausea and vomiting after TACE : a cross-sectional study
Version: 1 Date: 11 Nov 2024
Reviewer's report:
Overall this is an interesting study and I think it is important to determine risk factors in order to
better help alleviate symptoms for patients.  Below are thoughts and comments to help improve
the delivery of the content determined.
Abstract – This is a relevant topic.  To say it has good clinical efficacy may be a strength at this
point and would not include this within the abstract
Intro – need to include a source for the statement “TACE should be performed along an extended
vascular route in order to achieve the benefits of reducing local tumor burden, preventing
postoperative recurrence, and improving overall survival rates”
Paragraph 3 needs to be streamlined and unsure if we need to describe systemic chemotherapy
passing through the venous blood, too simplistic.
Typo “Therefore, considering the hazard of nausea and vomiting after TACE, his study
integrated personal”
Methods
Please describe ‘severe complications’ a bit more clearly
Perhaps a graph describing patient selection would help clarify the methods
The time frame of the patients symptoms are not clear
Was there a difference between nausea, vomiting and both?
Results
Vomiting is misspelled several times in this section including in table 1
Please describe nausea and vomiting separately, they can be very different symptoms or describe
it as nausea and/or vomiting
Typo, evaluation is listed 2 times : Accuracy evaluation evaluation of the risk model
Discussion
Sections 1 and 2: These sections are not really helpful and I’m unsure of its importance to what
was actually studied. These seem more like introduction paragraphs.  Somehow need to bring
back that these risks lead to more nausea/vomiting.
The 4 grades of side effects to chemo medications needs to be put in the methods when stating
why grade >2 was chosen
The discussion should highlight more of the risk factors.
Nursing implications
-Are you suggesting this questionnaire should be used clinically?  Or to know the top predictors
in order to best take care of patients/
Conclusion -  the term ‘most’ would not be appropriate given it was only 32%.  I would use
the term a third only here.
assistant