Reviewer ’s report  
 
Title: Prophylactic clip application for large pedunculated poly ps before snare polypectomy may 
decrease immediate postpolypectomy bleeding  
 
Version: 1 Date: 23 Jan 2020  
 
Reviewer: Sung Pil Hong  
 
Reviewer's report:  
 
In the present manuscript titled 'Prophylactic clip application for large pe dunculated polyps 
before snare polypectomy may decrease immediate postpolypectomy bleeding', Soh et al. 
performed a prospective randomized study to evaluate the efficacy of prophylactic clipping for 
preventing PPB in pedunculated colorectal polyps larger t han 10 mm. The study was prematurely 
terminated due to the high incidence of PPB in the arm of patients with non -prophylactic 
clipping. Polypectomy is performed widely, but it is still challenging to manage large 
pedunculated polyps.    
 
 
 
Major comments.  
 
1. It was designed as a prospective study, but it is not clearly described how many patients 
were enrolled and were excluded according to their criteria.  
 
 
2. As mentioned in the introduction, severe burn or perforation is major complication of 
clipping before  snare polypectomy. However, there is no description in the result section.     
 
 
 
Minor comments.  
 
1. Please describe how they treated patients with multiple polyps. It seems that they treated 
the patients with a single technique, but it is not clearly described in the method section.  
 
 
2. Is there any patient having other type of polyps?  
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some langu age corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests' below. If your reply is yes to any, please give details 
below.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Prophylactic clip application for large pedunculated poly ps before snare polypectomy may 
decrease immediate postpolypectomy bleeding  
 
Version: 1 Date: 23 Jan 2020  
 
Reviewer: Sung Pil Hong  
 
Reviewer's report:  
 
In the present manuscript titled 'Prophylactic clip application for large pe dunculated polyps 
before snare polypectomy may decrease immediate postpolypectomy bleeding', Soh et al. 
performed a prospective randomized study to evaluate the efficacy of prophylactic clipping for 
preventing PPB in pedunculated colorectal polyps larger t han 10 mm. The study was prematurely 
terminated due to the high incidence of PPB in the arm of patients with non -prophylactic 
clipping. Polypectomy is performed widely, but it is still challenging to manage large 
pedunculated polyps.    
 
 
 
Major comments.  
 
1. It was designed as a prospective study, but it is not clearly described how many patients 
were enrolled and were excluded according to their criteria.  
 
 
2. As mentioned in the introduction, severe burn or perforation is major complication of 
clipping before  snare polypectomy. However, there is no description in the result section.     
 
 
 
Minor comments.  
 
1. Please describe how they treated patients with multiple polyps. It seems that they treated 
the patients with a single technique, but it is not clearly described in the method section.  
 
 
2. Is there any patient having other type of polyps?  
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some langu age corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests' below. If your reply is yes to any, please give details 
below.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Prophylactic clip application for large pedunculated poly ps before snare polypectomy may 
decrease immediate postpolypectomy bleeding  
 
Version: 1 Date: 23 Jan 2020  
 
Reviewer: Sung Pil Hong  
 
Reviewer's report:  
 
In the present manuscript titled 'Prophylactic clip application for large pe dunculated polyps 
before snare polypectomy may decrease immediate postpolypectomy bleeding', Soh et al. 
performed a prospective randomized study to evaluate the efficacy of prophylactic clipping for 
preventing PPB in pedunculated colorectal polyps larger t han 10 mm. The study was prematurely 
terminated due to the high incidence of PPB in the arm of patients with non -prophylactic 
clipping. Polypectomy is performed widely, but it is still challenging to manage large 
pedunculated polyps.    
 
 
 
Major comments.  
 
1. It was designed as a prospective study, but it is not clearly described how many patients 
were enrolled and were excluded according to their criteria.  
 
 
2. As mentioned in the introduction, severe burn or perforation is major complication of 
clipping before  snare polypectomy. However, there is no description in the result section.     
 
 
 
Minor comments.  
 
1. Please describe how they treated patients with multiple polyps. It seems that they treated 
the patients with a single technique, but it is not clearly described in the method section.  
 
 
2. Is there any patient having other type of polyps?  
 
 
 
 
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some langu age corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests' below. If your reply is yes to any, please give details 
below.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant