Reviewer's report
Title:Improvement of endocytoscopic findings after per oral endoscopic
myotomy (POEM) in esophageal achalasia; Does POEM reduce the risk of
developing esophageal carcinoma?
Version: 4Date:25 December 2012
Reviewer: Tsutomu Nomura
Reviewer's report:
Major Compulsory Revisions
This study aims to evaluate the effectiveness of POEM in patients with
esophageal achalasia. The authors claim that POEM is an effective and less
invasive treatment for achalasia and may reduce the risk of esophageal
carcinogenesis.
For the benefit of the reader, however, several points need clarifying and certain
statements, which are given below.
1) In discussion, page 10/33, line5-7#Inoue et al. reported that there was no
recurrence after the POEM procedure in their 17 case series of achalasia[10].
#In their report (reference No 10), the mean follow-up period was 5 months. More
long follow-up period should be needed to claim#there was no recurrence after
the POEM procedure#.
2) In discussion, page 11/33, line20-21#Expression of the Ki-67 protein is
associated with the clinical course of mucosal inflammation[25].#
#In the report (reference No 25), I could not find the description. In abstract, they
mentioned that the expression of the Ki-67 protein is associated with the clinical
course of cancer (breast and prostate), but did not mention of correlation with
mucosal inflammation.
3) In discussion, page 11/33, line21 #They suggested####
##They#are Dr. Leeuwenburgh? Dr. Scholzen?
4) The authors should discuss about the relationship between patients
characteristic (type, dilation, duration of disease etc.) and the results of
endocytoscopy, Ki67 and p53.
5) The authors should check the references.
#reference 12 #Dis Esophagus, 2011#
##Dis Esophagus,2012 Apr;25(3):235-41. doi #?
#reference 28#American journal of gastroenterology#
##Am J Gastroenterol#?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Improvement of endocytoscopic findings after per oral endoscopic
myotomy (POEM) in esophageal achalasia; Does POEM reduce the risk of
developing esophageal carcinoma?
Version: 4Date:25 December 2012
Reviewer: Tsutomu Nomura
Reviewer's report:
Major Compulsory Revisions
This study aims to evaluate the effectiveness of POEM in patients with
esophageal achalasia. The authors claim that POEM is an effective and less
invasive treatment for achalasia and may reduce the risk of esophageal
carcinogenesis.
For the benefit of the reader, however, several points need clarifying and certain
statements, which are given below.
1) In discussion, page 10/33, line5-7#Inoue et al. reported that there was no
recurrence after the POEM procedure in their 17 case series of achalasia[10].
#In their report (reference No 10), the mean follow-up period was 5 months. More
long follow-up period should be needed to claim#there was no recurrence after
the POEM procedure#.
2) In discussion, page 11/33, line20-21#Expression of the Ki-67 protein is
associated with the clinical course of mucosal inflammation[25].#
#In the report (reference No 25), I could not find the description. In abstract, they
mentioned that the expression of the Ki-67 protein is associated with the clinical
course of cancer (breast and prostate), but did not mention of correlation with
mucosal inflammation.
3) In discussion, page 11/33, line21 #They suggested####
##They#are Dr. Leeuwenburgh? Dr. Scholzen?
4) The authors should discuss about the relationship between patients
characteristic (type, dilation, duration of disease etc.) and the results of
endocytoscopy, Ki67 and p53.
5) The authors should check the references.
#reference 12 #Dis Esophagus, 2011#
##Dis Esophagus,2012 Apr;25(3):235-41. doi #?
#reference 28#American journal of gastroenterology#
##Am J Gastroenterol#?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Improvement of endocytoscopic findings after per oral endoscopic
myotomy (POEM) in esophageal achalasia; Does POEM reduce the risk of
developing esophageal carcinoma?
Version: 4Date:25 December 2012
Reviewer: Tsutomu Nomura
Reviewer's report:
Major Compulsory Revisions
This study aims to evaluate the effectiveness of POEM in patients with
esophageal achalasia. The authors claim that POEM is an effective and less
invasive treatment for achalasia and may reduce the risk of esophageal
carcinogenesis.
For the benefit of the reader, however, several points need clarifying and certain
statements, which are given below.
1) In discussion, page 10/33, line5-7#Inoue et al. reported that there was no
recurrence after the POEM procedure in their 17 case series of achalasia[10].
#In their report (reference No 10), the mean follow-up period was 5 months. More
long follow-up period should be needed to claim#there was no recurrence after
the POEM procedure#.
2) In discussion, page 11/33, line20-21#Expression of the Ki-67 protein is
associated with the clinical course of mucosal inflammation[25].#
#In the report (reference No 25), I could not find the description. In abstract, they
mentioned that the expression of the Ki-67 protein is associated with the clinical
course of cancer (breast and prostate), but did not mention of correlation with
mucosal inflammation.
3) In discussion, page 11/33, line21 #They suggested####
##They#are Dr. Leeuwenburgh? Dr. Scholzen?
4) The authors should discuss about the relationship between patients
characteristic (type, dilation, duration of disease etc.) and the results of
endocytoscopy, Ki67 and p53.
5) The authors should check the references.
#reference 12 #Dis Esophagus, 2011#
##Dis Esophagus,2012 Apr;25(3):235-41. doi #?
#reference 28#American journal of gastroenterology#
##Am J Gastroenterol#?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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