Title: Hypertension and diabetes mellitus are associated with high FIB-4 index in a health
checkup examination cohort without known liver disease
Version: 1 Date: 09 Jun 2022
Reviewer's report:
Review of “Hypertension and diabetes mellitus are associated with high FIB-4 index in a health
checkup examination cohort without known liver disease”
This study investigated the background of high FIB-4 index in the apparent health people
and found that hypertension and diabetes mellitus are associated with high FIB-4 index in the
apparent health people. This study is potentially interesting; however, several problems to be
solved.
1. To add the definition of cardiovascular disease in the Method section.
2. This reviewer understands that FIB-4 index was useful for diagnose liver fibrosis in the
patients with NAFLD or fatty liver disease. How to diagnose having NAFLD or fatty liver
disease? Did the authors evaluate the NAFLD or fatty liver disease by image?
3. Or, please discuss the usefulness of FIB-4 index in the people without NAFLD or fatty liver
disease.
4. How to evaluate the lifestyle factors, especially alcohol consumption?
Title: Hypertension and diabetes mellitus are associated with high FIB-4 index in a health
checkup examination cohort without known liver disease
Version: 1 Date: 09 Jun 2022
Reviewer's report:
Review of “Hypertension and diabetes mellitus are associated with high FIB-4 index in a health
checkup examination cohort without known liver disease”
This study investigated the background of high FIB-4 index in the apparent health people
and found that hypertension and diabetes mellitus are associated with high FIB-4 index in the
apparent health people. This study is potentially interesting; however, several problems to be
solved.
1. To add the definition of cardiovascular disease in the Method section.
2. This reviewer understands that FIB-4 index was useful for diagnose liver fibrosis in the
patients with NAFLD or fatty liver disease. How to diagnose having NAFLD or fatty liver
disease? Did the authors evaluate the NAFLD or fatty liver disease by image?
3. Or, please discuss the usefulness of FIB-4 index in the people without NAFLD or fatty liver
disease.
4. How to evaluate the lifestyle factors, especially alcohol consumption?
Please review this paper.
user
Title: Hypertension and diabetes mellitus are associated with high FIB-4 index in a health
checkup examination cohort without known liver disease
Version: 1 Date: 09 Jun 2022
Reviewer's report:
Review of “Hypertension and diabetes mellitus are associated with high FIB-4 index in a health
checkup examination cohort without known liver disease”
This study investigated the background of high FIB-4 index in the apparent health people
and found that hypertension and diabetes mellitus are associated with high FIB-4 index in the
apparent health people. This study is potentially interesting; however, several problems to be
solved.
1. To add the definition of cardiovascular disease in the Method section.
2. This reviewer understands that FIB-4 index was useful for diagnose liver fibrosis in the
patients with NAFLD or fatty liver disease. How to diagnose having NAFLD or fatty liver
disease? Did the authors evaluate the NAFLD or fatty liver disease by image?
3. Or, please discuss the usefulness of FIB-4 index in the people without NAFLD or fatty liver
disease.
4. How to evaluate the lifestyle factors, especially alcohol consumption?
assistant