Title:  The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control
study
Version: 2 Date: 01 Jul 2024
Reviewer's report:
I have reviewed the manuscript.
The study addresses a very current topic, but the number of patients is not sufficient to draw
a conclusion. When assessing the disease and evaluating vitamin D levels, the duration of the
disease is very important. In addition, other important factors such as parathyroid hormone
levels, calcium levels, and whether the patient has chronic kidney disease have not been
included. The relevance of whether the patient had COVID-19, as indicated in the table, is
unclear to the topic. The concept of a treatment-refractory patient is not well defined. It is unclear
whether it refers to a patient unresponsive to first-line treatments or a patient unresponsive to
steroids. The reason why first-degree relatives of the patients were chosen as the control group
should be explained.
In its current form, the manuscript does not seem suitable for publication in the journal.
Title:  The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control
study
Version: 2 Date: 01 Jul 2024
Reviewer's report:
I have reviewed the manuscript.
The study addresses a very current topic, but the number of patients is not sufficient to draw
a conclusion. When assessing the disease and evaluating vitamin D levels, the duration of the
disease is very important. In addition, other important factors such as parathyroid hormone
levels, calcium levels, and whether the patient has chronic kidney disease have not been
included. The relevance of whether the patient had COVID-19, as indicated in the table, is
unclear to the topic. The concept of a treatment-refractory patient is not well defined. It is unclear
whether it refers to a patient unresponsive to first-line treatments or a patient unresponsive to
steroids. The reason why first-degree relatives of the patients were chosen as the control group
should be explained.
In its current form, the manuscript does not seem suitable for publication in the journal.
Please review this paper.
user
Title:  The role of vitamin D in treated and refractory ulcerative colitis patients: a case-control
study
Version: 2 Date: 01 Jul 2024
Reviewer's report:
I have reviewed the manuscript.
The study addresses a very current topic, but the number of patients is not sufficient to draw
a conclusion. When assessing the disease and evaluating vitamin D levels, the duration of the
disease is very important. In addition, other important factors such as parathyroid hormone
levels, calcium levels, and whether the patient has chronic kidney disease have not been
included. The relevance of whether the patient had COVID-19, as indicated in the table, is
unclear to the topic. The concept of a treatment-refractory patient is not well defined. It is unclear
whether it refers to a patient unresponsive to first-line treatments or a patient unresponsive to
steroids. The reason why first-degree relatives of the patients were chosen as the control group
should be explained.
In its current form, the manuscript does not seem suitable for publication in the journal.
assistant