Reviewer's report
Title:Contrast enhanced ultrasound findings in Peripheral Anaplastic T Cell
Lymphoma, revealed as Cavitating Mesenteric Lymph Node Syndrom in Celiac
Disease
Version: 1Date:25 August 2012
Reviewer: Benjamin Lebwohl
Reviewer's report:
Major Compulsory Revisions
The manuscript needs editing for grammar and language; there are errors of
tense agreement, single/plural agreement, and other language errors. As an
example, the sentence regarding consent reads "The consent for publication was
sign by the son’s patient (as the patient died)." This should be changed to "The
consent for publication was signed by the patient's son (as the patient died)."
The authors use a "50%" figure differently in the Abstract and the Introduction. In
the Abstract, they write that cavitating mesenteric lymph node syndrome
(CMLNS) is associated with T cell lymphoma in 50% of cases. In the
Introduction, they write that CMLNS has a 50% mortality rate. Are both of these
statements true? If the 50% mortality rate is accurate, over what time horizon
does this span?
Re: the initial diagnosis of celiac disease. The biopsy is described as having
villous atrophy, crypt hyperplasia, and "chronic inflammation." The authors
should clarify whether the histopathologic findings included intraepithelial
lymphocytosis.
Minor Essential Revisions
The figures would be improved by the inclusion of arrows, e.g. pointing out the
enhancing rims in Figure 5 or the rare lymphocytes/plasmacytes at the periphery
in Figure 7.
Discretionary revisions
It would be useful to know whether tissue transglutaminase IgA was repeatedly
checked during follow-up, since a decline would support the authors' claim that
the patients was adherent to the gluten-free diet.
An image of the initial small bowel biopsy should be included, along with
comment on whether immunohistochemistry staining of intraepithelial
lymphocytes was performed (for CD3 and CD8) and whether T cell receptor
PCR/flow cytometry was performed.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Contrast enhanced ultrasound findings in Peripheral Anaplastic T Cell
Lymphoma, revealed as Cavitating Mesenteric Lymph Node Syndrom in Celiac
Disease
Version: 1Date:25 August 2012
Reviewer: Benjamin Lebwohl
Reviewer's report:
Major Compulsory Revisions
The manuscript needs editing for grammar and language; there are errors of
tense agreement, single/plural agreement, and other language errors. As an
example, the sentence regarding consent reads "The consent for publication was
sign by the son’s patient (as the patient died)." This should be changed to "The
consent for publication was signed by the patient's son (as the patient died)."
The authors use a "50%" figure differently in the Abstract and the Introduction. In
the Abstract, they write that cavitating mesenteric lymph node syndrome
(CMLNS) is associated with T cell lymphoma in 50% of cases. In the
Introduction, they write that CMLNS has a 50% mortality rate. Are both of these
statements true? If the 50% mortality rate is accurate, over what time horizon
does this span?
Re: the initial diagnosis of celiac disease. The biopsy is described as having
villous atrophy, crypt hyperplasia, and "chronic inflammation." The authors
should clarify whether the histopathologic findings included intraepithelial
lymphocytosis.
Minor Essential Revisions
The figures would be improved by the inclusion of arrows, e.g. pointing out the
enhancing rims in Figure 5 or the rare lymphocytes/plasmacytes at the periphery
in Figure 7.
Discretionary revisions
It would be useful to know whether tissue transglutaminase IgA was repeatedly
checked during follow-up, since a decline would support the authors' claim that
the patients was adherent to the gluten-free diet.
An image of the initial small bowel biopsy should be included, along with
comment on whether immunohistochemistry staining of intraepithelial
lymphocytes was performed (for CD3 and CD8) and whether T cell receptor
PCR/flow cytometry was performed.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Contrast enhanced ultrasound findings in Peripheral Anaplastic T Cell
Lymphoma, revealed as Cavitating Mesenteric Lymph Node Syndrom in Celiac
Disease
Version: 1Date:25 August 2012
Reviewer: Benjamin Lebwohl
Reviewer's report:
Major Compulsory Revisions
The manuscript needs editing for grammar and language; there are errors of
tense agreement, single/plural agreement, and other language errors. As an
example, the sentence regarding consent reads "The consent for publication was
sign by the son’s patient (as the patient died)." This should be changed to "The
consent for publication was signed by the patient's son (as the patient died)."
The authors use a "50%" figure differently in the Abstract and the Introduction. In
the Abstract, they write that cavitating mesenteric lymph node syndrome
(CMLNS) is associated with T cell lymphoma in 50% of cases. In the
Introduction, they write that CMLNS has a 50% mortality rate. Are both of these
statements true? If the 50% mortality rate is accurate, over what time horizon
does this span?
Re: the initial diagnosis of celiac disease. The biopsy is described as having
villous atrophy, crypt hyperplasia, and "chronic inflammation." The authors
should clarify whether the histopathologic findings included intraepithelial
lymphocytosis.
Minor Essential Revisions
The figures would be improved by the inclusion of arrows, e.g. pointing out the
enhancing rims in Figure 5 or the rare lymphocytes/plasmacytes at the periphery
in Figure 7.
Discretionary revisions
It would be useful to know whether tissue transglutaminase IgA was repeatedly
checked during follow-up, since a decline would support the authors' claim that
the patients was adherent to the gluten-free diet.
An image of the initial small bowel biopsy should be included, along with
comment on whether immunohistochemistry staining of intraepithelial
lymphocytes was performed (for CD3 and CD8) and whether T cell receptor
PCR/flow cytometry was performed.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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