Reviewer's report
Title:Serum adiponectin and transient elastography (FibroScan) as non-invasive
markers for postoperative biliary atresia
Version: 1Date:20 January 2011
Reviewer: Themis Silveira
Reviewer's report:
RE: 'Serum adiponectin and transient elastography (FibroScan) as non-invasive
markers for postoperative biliary atresia'
Peer review:Themis Reverbel da Silveira MD, PhD
- "It is a very good article about Biliary Atresia (BA) and an attempt to develop
noninvasive tests for the assessment of fibrogenic progression of this disease.
The article follows a successful investigational research subject: the role of
cytokines and growth factors in physiopathology of BA .The authors (prof. Yong
Poovorawan and colaborators) recently reported interesting results related to
biochemical parameters like basic fibroblast growth factor, stem cell factor, bone
morphogenetic protein 7 and osteopontin in |BA. Concerning elastography , a
new medical technique recently used in children, normal values have not yet
been validated in children and deserve further and prospective studies. I suggest
that one reference could be added: de Ledinghen V et al. "Liver stiffness
measurement in children using FibroScan: feasibility study and comparison with
Fibrotest, aspartate transaminase to platelets ratio index and liver biopsy".
Journal of Pediatric Gastroenterology and Nutrition 2007; 45: 443.
In conclusion: this investigation showed, nicely, the potential role of serum
adiponectin and elastography for monitoring the progression of hepatic fibrosis in
BA patients."
Peer review:Themis Reverbel da Silveira MD, PhD
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Serum adiponectin and transient elastography (FibroScan) as non-invasive
markers for postoperative biliary atresia
Version: 1Date:20 January 2011
Reviewer: Themis Silveira
Reviewer's report:
RE: 'Serum adiponectin and transient elastography (FibroScan) as non-invasive
markers for postoperative biliary atresia'
Peer review:Themis Reverbel da Silveira MD, PhD
- "It is a very good article about Biliary Atresia (BA) and an attempt to develop
noninvasive tests for the assessment of fibrogenic progression of this disease.
The article follows a successful investigational research subject: the role of
cytokines and growth factors in physiopathology of BA .The authors (prof. Yong
Poovorawan and colaborators) recently reported interesting results related to
biochemical parameters like basic fibroblast growth factor, stem cell factor, bone
morphogenetic protein 7 and osteopontin in |BA. Concerning elastography , a
new medical technique recently used in children, normal values have not yet
been validated in children and deserve further and prospective studies. I suggest
that one reference could be added: de Ledinghen V et al. "Liver stiffness
measurement in children using FibroScan: feasibility study and comparison with
Fibrotest, aspartate transaminase to platelets ratio index and liver biopsy".
Journal of Pediatric Gastroenterology and Nutrition 2007; 45: 443.
In conclusion: this investigation showed, nicely, the potential role of serum
adiponectin and elastography for monitoring the progression of hepatic fibrosis in
BA patients."
Peer review:Themis Reverbel da Silveira MD, PhD
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Serum adiponectin and transient elastography (FibroScan) as non-invasive
markers for postoperative biliary atresia
Version: 1Date:20 January 2011
Reviewer: Themis Silveira
Reviewer's report:
RE: 'Serum adiponectin and transient elastography (FibroScan) as non-invasive
markers for postoperative biliary atresia'
Peer review:Themis Reverbel da Silveira MD, PhD
- "It is a very good article about Biliary Atresia (BA) and an attempt to develop
noninvasive tests for the assessment of fibrogenic progression of this disease.
The article follows a successful investigational research subject: the role of
cytokines and growth factors in physiopathology of BA .The authors (prof. Yong
Poovorawan and colaborators) recently reported interesting results related to
biochemical parameters like basic fibroblast growth factor, stem cell factor, bone
morphogenetic protein 7 and osteopontin in |BA. Concerning elastography , a
new medical technique recently used in children, normal values have not yet
been validated in children and deserve further and prospective studies. I suggest
that one reference could be added: de Ledinghen V et al. "Liver stiffness
measurement in children using FibroScan: feasibility study and comparison with
Fibrotest, aspartate transaminase to platelets ratio index and liver biopsy".
Journal of Pediatric Gastroenterology and Nutrition 2007; 45: 443.
In conclusion: this investigation showed, nicely, the potential role of serum
adiponectin and elastography for monitoring the progression of hepatic fibrosis in
BA patients."
Peer review:Themis Reverbel da Silveira MD, PhD
Level of interest: An article of outstanding merit and interest in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant