Reviewer's report 
 The Changes in Renal Function after a Single Dose of intravenous Furosemide in Patients with Title: 
Compensated Liver cirrhosis 
 4  2 November 2006 Version: Date: 
 Giuliano Ramadori Reviewer: 
Reviewer's report: 
General 
I read the manuscript and the comments as well the answer to the comments. 
I would suggest that the authors introduce the concept of a 
Subclinical hypovolaemia in patients with Child A-cirrhosis in the introduction 
Mentioning the paper Caregaro et.al Eur J Clin Invest (1985)15:360-364 
And discussing the eventual importance of using the the DMSA-uptake unde furosemide-administration 
To identify those patients who could develop kidney-problems under diuretics and 
To further discriminate those patients within the Child A-cirrhosis-patients. 
A further study could than be performed in those patients with reduced uptake after 
albumin-administration.Also this concept should be introduced in the discussion 
Mentioning Schindler et al.JHepatol (1999) 31:1132 and J Trotter et al.Dig.Dis.Sci(2005)50:1356-1360 
The paper could than be published. 
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Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
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Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
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Discretionary Revisions (which the author can choose to ignore) 
Reviewer's report 
 The Changes in Renal Function after a Single Dose of intravenous Furosemide in Patients with Title: 
Compensated Liver cirrhosis 
 4  2 November 2006 Version: Date: 
 Giuliano Ramadori Reviewer: 
Reviewer's report: 
General 
I read the manuscript and the comments as well the answer to the comments. 
I would suggest that the authors introduce the concept of a 
Subclinical hypovolaemia in patients with Child A-cirrhosis in the introduction 
Mentioning the paper Caregaro et.al Eur J Clin Invest (1985)15:360-364 
And discussing the eventual importance of using the the DMSA-uptake unde furosemide-administration 
To identify those patients who could develop kidney-problems under diuretics and 
To further discriminate those patients within the Child A-cirrhosis-patients. 
A further study could than be performed in those patients with reduced uptake after 
albumin-administration.Also this concept should be introduced in the discussion 
Mentioning Schindler et al.JHepatol (1999) 31:1132 and J Trotter et al.Dig.Dis.Sci(2005)50:1356-1360 
The paper could than be published. 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
Please review this paper.
user
Reviewer's report 
 The Changes in Renal Function after a Single Dose of intravenous Furosemide in Patients with Title: 
Compensated Liver cirrhosis 
 4  2 November 2006 Version: Date: 
 Giuliano Ramadori Reviewer: 
Reviewer's report: 
General 
I read the manuscript and the comments as well the answer to the comments. 
I would suggest that the authors introduce the concept of a 
Subclinical hypovolaemia in patients with Child A-cirrhosis in the introduction 
Mentioning the paper Caregaro et.al Eur J Clin Invest (1985)15:360-364 
And discussing the eventual importance of using the the DMSA-uptake unde furosemide-administration 
To identify those patients who could develop kidney-problems under diuretics and 
To further discriminate those patients within the Child A-cirrhosis-patients. 
A further study could than be performed in those patients with reduced uptake after 
albumin-administration.Also this concept should be introduced in the discussion 
Mentioning Schindler et al.JHepatol (1999) 31:1132 and J Trotter et al.Dig.Dis.Sci(2005)50:1356-1360 
The paper could than be published. 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
assistant