Reviewer’s report
Title:  The influence of various distractions prior to upper gastrointestinal endoscopy: A Prospective
Randomized Controlled Study
Version: 1 Date: 21 Apr 2018
Reviewer: Kuan-Chih Chen
This is a prospective randomized controlled study to investigate the influence of interventions using
either audio or visual distractions or combination of both for person who is going to undergo upper GI
endoscopy. The study is well designed, and the manuscript is well written as well. However, there are
several questions about this study.
1.How many people received upper GI endoscopy for regular health check-up in study period at
your institution? What's the proportion of those who received upper GI endoscopy for regular
health check-up without sedation?
2.What's  the  characteristics  of  those  who  hoped  to  undergo  upper  GI  endoscopy without
sedation in comparison with those under the procedure with sedation?
3.What is the average procedure time of each group? Do they have significant difference of
procedure time between these groups? 
4.Can you explain that although the satisfaction for the distraction has significant difference
among the three groups, willingness for the use of distraction has no difference? 
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional 
statistical review?
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose financially 
from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds or 
has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If 
your reply is yes to any, please give details below.
I declare that I have no competing interests.
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
Reviewer’s report
Title:  The influence of various distractions prior to upper gastrointestinal endoscopy: A Prospective
Randomized Controlled Study
Version: 1 Date: 21 Apr 2018
Reviewer: Kuan-Chih Chen
This is a prospective randomized controlled study to investigate the influence of interventions using
either audio or visual distractions or combination of both for person who is going to undergo upper GI
endoscopy. The study is well designed, and the manuscript is well written as well. However, there are
several questions about this study.
1.How many people received upper GI endoscopy for regular health check-up in study period at
your institution? What's the proportion of those who received upper GI endoscopy for regular
health check-up without sedation?
2.What's  the  characteristics  of  those  who  hoped  to  undergo  upper  GI  endoscopy without
sedation in comparison with those under the procedure with sedation?
3.What is the average procedure time of each group? Do they have significant difference of
procedure time between these groups? 
4.Can you explain that although the satisfaction for the distraction has significant difference
among the three groups, willingness for the use of distraction has no difference? 
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional 
statistical review?
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose financially 
from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds or 
has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If 
your reply is yes to any, please give details below.
I declare that I have no competing interests.
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
Please review this paper.
user
Reviewer’s report
Title:  The influence of various distractions prior to upper gastrointestinal endoscopy: A Prospective
Randomized Controlled Study
Version: 1 Date: 21 Apr 2018
Reviewer: Kuan-Chih Chen
This is a prospective randomized controlled study to investigate the influence of interventions using
either audio or visual distractions or combination of both for person who is going to undergo upper GI
endoscopy. The study is well designed, and the manuscript is well written as well. However, there are
several questions about this study.
1.How many people received upper GI endoscopy for regular health check-up in study period at
your institution? What's the proportion of those who received upper GI endoscopy for regular
health check-up without sedation?
2.What's  the  characteristics  of  those  who  hoped  to  undergo  upper  GI  endoscopy without
sedation in comparison with those under the procedure with sedation?
3.What is the average procedure time of each group? Do they have significant difference of
procedure time between these groups? 
4.Can you explain that although the satisfaction for the distraction has significant difference
among the three groups, willingness for the use of distraction has no difference? 
Are the methods appropriate and well described?
If not, please specify what is required in your comments to the authors.
Yes
Does the work include the necessary controls?
If not, please specify which controls are required in your comments to the authors.
Yes
Are the conclusions drawn adequately supported by the data shown?
If not, please explain in your comments to the authors.
Yes
Are you able to assess any statistics in the manuscript or would you recommend an additional 
statistical review?
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.
I am able to assess the statistics
Quality of written English
Please indicate the quality of language in the manuscript:
Acceptable
Declaration of competing interests
Please complete a declaration of competing interests, considering the following questions:
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose financially 
from the publication of this manuscript, either now or in the future?
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?
4. Have you received reimbursements, fees, funding, or salary from an organization that holds or 
has applied for patents relating to the content of the manuscript?
5. Do you have any other financial competing interests?
6. Do you have any non-financial competing interests in relation to this paper?
If you can answer no to all of the above, write 'I declare that I have no competing interests' below. If 
your reply is yes to any, please give details below.
I declare that I have no competing interests.
I agree to the open peer review policy of the journal. I understand that my name will be included on my
report to the authors and, if the manuscript is accepted for publication, my named report including any 
attachments I upload will be posted on the website along with the authors' responses. I agree for my 
report to be made available under an Open Access Creative Commons CC-BY license 
(http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments which I do not wish to 
be included in my named report can be included as confidential comments to the editors, which will not
be published.
I agree to the open peer review policy of the journal
assistant