Reviewer's report
Title:CD44 but not CD24 expressions are related to poor prognosis in gastric
cancer
Version:1Date:13 March 2014
Reviewer: Hideo Baba
Reviewer's report:
In this study, authors presented that individual expression of CD44 was
associated with poor survival of gastric carcinoma. But they also showed there is
no significant correlation between expression of CD24 and prognosis. Then
authors concluded CD44 is clinically useful for prediction of gastric cancer. This
study is not novel because they only reveal correlation between CD44 and
prognosis of gastric cancer that had been reported many times. Furthermore,
although authors concluded that CD44 might play important role in the gastric
carcinogenesis in the abstract, it sounds too much to conclude there is
correlation between carcinogenesis and CD44 only because of correlation
between CD44 and prognosis.
Major query
1. The conclusion of abstract is not consistent with that of main article. If authors
conclude CD44 might play important role in the gastric carcinogenesis, authors
should reveal correlation between CD44 and carcinogenesis. This study only
shows CD44 and prognosis.
2. The contents in this report are not novel enough to publish. Authors rewrite the
article after something novel is revealed such as correlation between CD24 and
prognosis.
Minor query
1. There are many reports about CD44 and stem cells. Authors should show
more appropriate references.
2. Many grammatical mistakes are found. We recommend performing English
proofreading.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:CD44 but not CD24 expressions are related to poor prognosis in gastric
cancer
Version:1Date:13 March 2014
Reviewer: Hideo Baba
Reviewer's report:
In this study, authors presented that individual expression of CD44 was
associated with poor survival of gastric carcinoma. But they also showed there is
no significant correlation between expression of CD24 and prognosis. Then
authors concluded CD44 is clinically useful for prediction of gastric cancer. This
study is not novel because they only reveal correlation between CD44 and
prognosis of gastric cancer that had been reported many times. Furthermore,
although authors concluded that CD44 might play important role in the gastric
carcinogenesis in the abstract, it sounds too much to conclude there is
correlation between carcinogenesis and CD44 only because of correlation
between CD44 and prognosis.
Major query
1. The conclusion of abstract is not consistent with that of main article. If authors
conclude CD44 might play important role in the gastric carcinogenesis, authors
should reveal correlation between CD44 and carcinogenesis. This study only
shows CD44 and prognosis.
2. The contents in this report are not novel enough to publish. Authors rewrite the
article after something novel is revealed such as correlation between CD24 and
prognosis.
Minor query
1. There are many reports about CD44 and stem cells. Authors should show
more appropriate references.
2. Many grammatical mistakes are found. We recommend performing English
proofreading.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:CD44 but not CD24 expressions are related to poor prognosis in gastric
cancer
Version:1Date:13 March 2014
Reviewer: Hideo Baba
Reviewer's report:
In this study, authors presented that individual expression of CD44 was
associated with poor survival of gastric carcinoma. But they also showed there is
no significant correlation between expression of CD24 and prognosis. Then
authors concluded CD44 is clinically useful for prediction of gastric cancer. This
study is not novel because they only reveal correlation between CD44 and
prognosis of gastric cancer that had been reported many times. Furthermore,
although authors concluded that CD44 might play important role in the gastric
carcinogenesis in the abstract, it sounds too much to conclude there is
correlation between carcinogenesis and CD44 only because of correlation
between CD44 and prognosis.
Major query
1. The conclusion of abstract is not consistent with that of main article. If authors
conclude CD44 might play important role in the gastric carcinogenesis, authors
should reveal correlation between CD44 and carcinogenesis. This study only
shows CD44 and prognosis.
2. The contents in this report are not novel enough to publish. Authors rewrite the
article after something novel is revealed such as correlation between CD24 and
prognosis.
Minor query
1. There are many reports about CD44 and stem cells. Authors should show
more appropriate references.
2. Many grammatical mistakes are found. We recommend performing English
proofreading.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant