Reviewer's report
Title:Imbalanced shift of cytokine expression between T helper 1 and T helper 2
(Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel
syndrome
Version: 1Date:25 March 2012
Reviewer: Junping Wang
Reviewer's report:
In the present study, the authors found that the intestinal mucosa of PI-IBS
patients exhibits an increased IFN-# and decreased IL-10 levels, suggested the
infection may affects the Th1/Th2 balance. The deregulations of immune
response are likely an important cause of IBS. The study is well designed and
the description of the results and technologies are clear. The study had clinical
meaningfulness. However, the article should be revised according to the
following comments:
Discretionary Revisions
1. How long did patients with acute gastroenteritis and bacillary dysentery
develop to PI-IBS.
2. D-IBS and C-IBS may have different pathogenesis, if possible, separated
D-IBS to C-IBS.
Minor Essential Revisions
1. It is better to cite the references within past 3 years.
2. The figure and the notes should not be separated in different pages.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Imbalanced shift of cytokine expression between T helper 1 and T helper 2
(Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel
syndrome
Version: 1Date:25 March 2012
Reviewer: Junping Wang
Reviewer's report:
In the present study, the authors found that the intestinal mucosa of PI-IBS
patients exhibits an increased IFN-# and decreased IL-10 levels, suggested the
infection may affects the Th1/Th2 balance. The deregulations of immune
response are likely an important cause of IBS. The study is well designed and
the description of the results and technologies are clear. The study had clinical
meaningfulness. However, the article should be revised according to the
following comments:
Discretionary Revisions
1. How long did patients with acute gastroenteritis and bacillary dysentery
develop to PI-IBS.
2. D-IBS and C-IBS may have different pathogenesis, if possible, separated
D-IBS to C-IBS.
Minor Essential Revisions
1. It is better to cite the references within past 3 years.
2. The figure and the notes should not be separated in different pages.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Imbalanced shift of cytokine expression between T helper 1 and T helper 2
(Th1/Th2) in intestinal mucosa of patients with post-infectious irritable bowel
syndrome
Version: 1Date:25 March 2012
Reviewer: Junping Wang
Reviewer's report:
In the present study, the authors found that the intestinal mucosa of PI-IBS
patients exhibits an increased IFN-# and decreased IL-10 levels, suggested the
infection may affects the Th1/Th2 balance. The deregulations of immune
response are likely an important cause of IBS. The study is well designed and
the description of the results and technologies are clear. The study had clinical
meaningfulness. However, the article should be revised according to the
following comments:
Discretionary Revisions
1. How long did patients with acute gastroenteritis and bacillary dysentery
develop to PI-IBS.
2. D-IBS and C-IBS may have different pathogenesis, if possible, separated
D-IBS to C-IBS.
Minor Essential Revisions
1. It is better to cite the references within past 3 years.
2. The figure and the notes should not be separated in different pages.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
assistant