Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 6 Date: 20 Sep 2024
Reviewer's report:
I thank the authors for revising the manuscript.
Since the authors do not want to conduct a rescue experiment to show that KIF3C regulates
proliferation and migration through PI3K/AKT signaling, I ask the authors to remove the phrase
‘through PI3K/AKT pathway’ from the title.
The data presented in the manuscript shows that PI3K/AKT as well as Bax, Bcl-2, and cyclin D1
pathways. There is no evidence to indicate that PI3K/AKT signaling is responsible for the effects
observed. Therefore, claiming that KIF3C acts through specifically PI3K/AKT signaling is not
appropriate. Keep this in mind, please edit the abstract, results and discussion section as well.
Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 6 Date: 20 Sep 2024
Reviewer's report:
I thank the authors for revising the manuscript.
Since the authors do not want to conduct a rescue experiment to show that KIF3C regulates
proliferation and migration through PI3K/AKT signaling, I ask the authors to remove the phrase
‘through PI3K/AKT pathway’ from the title.
The data presented in the manuscript shows that PI3K/AKT as well as Bax, Bcl-2, and cyclin D1
pathways. There is no evidence to indicate that PI3K/AKT signaling is responsible for the effects
observed. Therefore, claiming that KIF3C acts through specifically PI3K/AKT signaling is not
appropriate. Keep this in mind, please edit the abstract, results and discussion section as well.
Please review this paper.
user
Title: KIF3C inhibits the progression and proliferation of colorectal cancer
Version: 6 Date: 20 Sep 2024
Reviewer's report:
I thank the authors for revising the manuscript.
Since the authors do not want to conduct a rescue experiment to show that KIF3C regulates
proliferation and migration through PI3K/AKT signaling, I ask the authors to remove the phrase
‘through PI3K/AKT pathway’ from the title.
The data presented in the manuscript shows that PI3K/AKT as well as Bax, Bcl-2, and cyclin D1
pathways. There is no evidence to indicate that PI3K/AKT signaling is responsible for the effects
observed. Therefore, claiming that KIF3C acts through specifically PI3K/AKT signaling is not
appropriate. Keep this in mind, please edit the abstract, results and discussion section as well.
assistant