Title: Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in
patients with complex perianal fistulas in Crohn’s disease
Version: 5 Date: 16 Jul 2024
Reviewer's report:
The paper by Karki and co-workers has been meticulously prepared, the manuscript is well
written and the methodology  seems to be correct for me.
no major points:
minor points:
Following points should be considered:
line 39-42:  you found a difference between the groups which was described as  longer or a
higher estimated proportion of patients,. How significant is this difference? Is there the option
for a calculation (p) of this difference in your model?
Line 80: Meanwhile the American data of DVS have been published as an abstract. The
American data are somewhat contradictory to the European. So far we don't know why we find
this difference. I recommend however , to briefly mention and discuss these new data in the
introduction and in the discussion
332 . is missing
371; I don't think you should consider fistular diseaase as a rare disease.
325
Title: Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in
patients with complex perianal fistulas in Crohn’s disease
Version: 5 Date: 16 Jul 2024
Reviewer's report:
The paper by Karki and co-workers has been meticulously prepared, the manuscript is well
written and the methodology  seems to be correct for me.
no major points:
minor points:
Following points should be considered:
line 39-42:  you found a difference between the groups which was described as  longer or a
higher estimated proportion of patients,. How significant is this difference? Is there the option
for a calculation (p) of this difference in your model?
Line 80: Meanwhile the American data of DVS have been published as an abstract. The
American data are somewhat contradictory to the European. So far we don't know why we find
this difference. I recommend however , to briefly mention and discuss these new data in the
introduction and in the discussion
332 . is missing
371; I don't think you should consider fistular diseaase as a rare disease.
325
Please review this paper.
user
Title: Predictive modeling to evaluate long-term treatment effectiveness of darvadstrocel in
patients with complex perianal fistulas in Crohn’s disease
Version: 5 Date: 16 Jul 2024
Reviewer's report:
The paper by Karki and co-workers has been meticulously prepared, the manuscript is well
written and the methodology  seems to be correct for me.
no major points:
minor points:
Following points should be considered:
line 39-42:  you found a difference between the groups which was described as  longer or a
higher estimated proportion of patients,. How significant is this difference? Is there the option
for a calculation (p) of this difference in your model?
Line 80: Meanwhile the American data of DVS have been published as an abstract. The
American data are somewhat contradictory to the European. So far we don't know why we find
this difference. I recommend however , to briefly mention and discuss these new data in the
introduction and in the discussion
332 . is missing
371; I don't think you should consider fistular diseaase as a rare disease.
325
assistant