Reviewer's report
Title:Volume, distribution and acidity of gastric secretion on and off proton pump
inhibitor treatment: A randomized double-blind controlled study in patients with
gastro-esophageal reflux disease (GERD) and healthy subjects
Version:1Date:10 July 2015
Reviewer: michele cicala
Reviewer's report:
In this interesting investigation, the Authors aimed at assessing MRI technique to
visualize
and quantify volume and distribution of the acid pocket in healthy volunteers and
in patients with GERD, before and following high dose PPI therapy given for one
week. The design of the study
is correct, the main findings were a significant reduction of secretion volumes and
secretion layers
and a reduced contact time between secretions and EGJ following PPI, both in
patients and healthy subjects. MRI technique appears to be accurate in the
quantitative assessment of acid pocket and a promising tool for future trials on
novel drugs.
Some minor comments are:
GERD Patients were either affected by erosive esophagitis or uncomplicated,
although confirmed by pH test, disease. How many of them belonged to the
erosive population?
Similarly, findings of the symptom scores are not reported following placebo.
Besides the position - right decubitus - in which patients were investigated,
another limitation of this study is the test meal (pure liquid), both are
unphysiologic conditions.
Finally, the different distribution of gastric secretions within the proximal stomach
in GERD patients vs healthy subjects may be due, apart from different
morphology, to different motility of the proximal stomach in the two groups.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Volume, distribution and acidity of gastric secretion on and off proton pump
inhibitor treatment: A randomized double-blind controlled study in patients with
gastro-esophageal reflux disease (GERD) and healthy subjects
Version:1Date:10 July 2015
Reviewer: michele cicala
Reviewer's report:
In this interesting investigation, the Authors aimed at assessing MRI technique to
visualize
and quantify volume and distribution of the acid pocket in healthy volunteers and
in patients with GERD, before and following high dose PPI therapy given for one
week. The design of the study
is correct, the main findings were a significant reduction of secretion volumes and
secretion layers
and a reduced contact time between secretions and EGJ following PPI, both in
patients and healthy subjects. MRI technique appears to be accurate in the
quantitative assessment of acid pocket and a promising tool for future trials on
novel drugs.
Some minor comments are:
GERD Patients were either affected by erosive esophagitis or uncomplicated,
although confirmed by pH test, disease. How many of them belonged to the
erosive population?
Similarly, findings of the symptom scores are not reported following placebo.
Besides the position - right decubitus - in which patients were investigated,
another limitation of this study is the test meal (pure liquid), both are
unphysiologic conditions.
Finally, the different distribution of gastric secretions within the proximal stomach
in GERD patients vs healthy subjects may be due, apart from different
morphology, to different motility of the proximal stomach in the two groups.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Volume, distribution and acidity of gastric secretion on and off proton pump
inhibitor treatment: A randomized double-blind controlled study in patients with
gastro-esophageal reflux disease (GERD) and healthy subjects
Version:1Date:10 July 2015
Reviewer: michele cicala
Reviewer's report:
In this interesting investigation, the Authors aimed at assessing MRI technique to
visualize
and quantify volume and distribution of the acid pocket in healthy volunteers and
in patients with GERD, before and following high dose PPI therapy given for one
week. The design of the study
is correct, the main findings were a significant reduction of secretion volumes and
secretion layers
and a reduced contact time between secretions and EGJ following PPI, both in
patients and healthy subjects. MRI technique appears to be accurate in the
quantitative assessment of acid pocket and a promising tool for future trials on
novel drugs.
Some minor comments are:
GERD Patients were either affected by erosive esophagitis or uncomplicated,
although confirmed by pH test, disease. How many of them belonged to the
erosive population?
Similarly, findings of the symptom scores are not reported following placebo.
Besides the position - right decubitus - in which patients were investigated,
another limitation of this study is the test meal (pure liquid), both are
unphysiologic conditions.
Finally, the different distribution of gastric secretions within the proximal stomach
in GERD patients vs healthy subjects may be due, apart from different
morphology, to different motility of the proximal stomach in the two groups.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
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