Reviewer's report
Title:Duodenal carcinoma at the ligament of Treitz. A molecular and clinical
perspective.
Version: 1Date:14 June 2010
Reviewer: Patrick G Brady
Reviewer's report:
Minor Essential Revisions:
1.In the background, it should be mentioned that familial adenomatosis polyposis
(FAP) is associated with carcinoma of the duodenum. Although this is most
common in the second portion of the duodenum, it can aslo occur in the third and
fourth portions of the dudoenum. Gardner's syndrome is mentioned in the last
sentence of page 3 as a hereditary syndrome that increases the risk of small
bowel neoplasm. Gardner's syndrome is a variant of FAP.
2. On page 14 mutations in the APC gene are discussed. Duodenal carcinoma is
the second most common carcinoma in FAP. Thus the comments regarding the
low rate of APC mutations in duodenal adenocarcinoma refer primarily to
sporadic adenocarcinomas and not those associated with FAP and its variants.
3.Patients with duodenal adenomas and carcinomas have and increased risk of
colonic neoplasms. The case presentation illustrates this since the patient had
several colonic adenomas. Current recommendations call for colonoscopy in all
patients with duodenal adenomas and carcinomas. This needs to be pointed out
in the disscussion.
4. Celiac disease is another disorder assciated with an increased risk of small
bowel, including duodenal, carcinoma. This should be noted in the background
section.
5.On page 10, double balloon enteroscopy is discussed. Single balloon
enteroscopy is not mentioned. Since single balloon enteroscopy is an alternative
to double balloon enteroscopy with comparable success rates and yields, it
should be mentioned in the discussion. The term "balloon assisted enteroscopy"
can be applied to both techniques.
Discretionary Revisions:
Either figure 1 or figure 2 can be used, but both are not necessary.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Duodenal carcinoma at the ligament of Treitz. A molecular and clinical
perspective.
Version: 1Date:14 June 2010
Reviewer: Patrick G Brady
Reviewer's report:
Minor Essential Revisions:
1.In the background, it should be mentioned that familial adenomatosis polyposis
(FAP) is associated with carcinoma of the duodenum. Although this is most
common in the second portion of the duodenum, it can aslo occur in the third and
fourth portions of the dudoenum. Gardner's syndrome is mentioned in the last
sentence of page 3 as a hereditary syndrome that increases the risk of small
bowel neoplasm. Gardner's syndrome is a variant of FAP.
2. On page 14 mutations in the APC gene are discussed. Duodenal carcinoma is
the second most common carcinoma in FAP. Thus the comments regarding the
low rate of APC mutations in duodenal adenocarcinoma refer primarily to
sporadic adenocarcinomas and not those associated with FAP and its variants.
3.Patients with duodenal adenomas and carcinomas have and increased risk of
colonic neoplasms. The case presentation illustrates this since the patient had
several colonic adenomas. Current recommendations call for colonoscopy in all
patients with duodenal adenomas and carcinomas. This needs to be pointed out
in the disscussion.
4. Celiac disease is another disorder assciated with an increased risk of small
bowel, including duodenal, carcinoma. This should be noted in the background
section.
5.On page 10, double balloon enteroscopy is discussed. Single balloon
enteroscopy is not mentioned. Since single balloon enteroscopy is an alternative
to double balloon enteroscopy with comparable success rates and yields, it
should be mentioned in the discussion. The term "balloon assisted enteroscopy"
can be applied to both techniques.
Discretionary Revisions:
Either figure 1 or figure 2 can be used, but both are not necessary.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Duodenal carcinoma at the ligament of Treitz. A molecular and clinical
perspective.
Version: 1Date:14 June 2010
Reviewer: Patrick G Brady
Reviewer's report:
Minor Essential Revisions:
1.In the background, it should be mentioned that familial adenomatosis polyposis
(FAP) is associated with carcinoma of the duodenum. Although this is most
common in the second portion of the duodenum, it can aslo occur in the third and
fourth portions of the dudoenum. Gardner's syndrome is mentioned in the last
sentence of page 3 as a hereditary syndrome that increases the risk of small
bowel neoplasm. Gardner's syndrome is a variant of FAP.
2. On page 14 mutations in the APC gene are discussed. Duodenal carcinoma is
the second most common carcinoma in FAP. Thus the comments regarding the
low rate of APC mutations in duodenal adenocarcinoma refer primarily to
sporadic adenocarcinomas and not those associated with FAP and its variants.
3.Patients with duodenal adenomas and carcinomas have and increased risk of
colonic neoplasms. The case presentation illustrates this since the patient had
several colonic adenomas. Current recommendations call for colonoscopy in all
patients with duodenal adenomas and carcinomas. This needs to be pointed out
in the disscussion.
4. Celiac disease is another disorder assciated with an increased risk of small
bowel, including duodenal, carcinoma. This should be noted in the background
section.
5.On page 10, double balloon enteroscopy is discussed. Single balloon
enteroscopy is not mentioned. Since single balloon enteroscopy is an alternative
to double balloon enteroscopy with comparable success rates and yields, it
should be mentioned in the discussion. The term "balloon assisted enteroscopy"
can be applied to both techniques.
Discretionary Revisions:
Either figure 1 or figure 2 can be used, but both are not necessary.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant