Reviewer's report 
 A conscious mouse model of gastric ileus using clinically relevant endpoints. Title: 
 1  25 October 2004 Version: Date: 
 Anthony J Bauer Reviewer: 
Reviewer's report: 
The article submits the methodological premise that ileus can be equated with food intake (which 
would also result in changes in fecal output). Although, in some experimental models this may be 
experimentally valid many factors contribute to food intake, some of which have no barring on 
gastrointestinal motility. It is this reviewer’s understanding that “ileus” pertains to gastrointestinal 
motility and not the behavior to seek and ingest intake food. Therefore, decreased food intake does 
not equal ileus, as can be concluded from this manuscripts data on LPS. Although, food intake is not 
an invalid measurement – it is further removed from a direct gastrointestinal transit measurement. 
Hence, mechanistic interpretation becomes difficult. The results presented in this paper confirms 
previously published papers using more direct measures of gastrointestinal motility. 
 Reject because scientifically unsound What next?: 
 Too insignificant to warrant publication in any journal Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
No to all the above. 
None 
Reviewer's report 
 A conscious mouse model of gastric ileus using clinically relevant endpoints. Title: 
 1  25 October 2004 Version: Date: 
 Anthony J Bauer Reviewer: 
Reviewer's report: 
The article submits the methodological premise that ileus can be equated with food intake (which 
would also result in changes in fecal output). Although, in some experimental models this may be 
experimentally valid many factors contribute to food intake, some of which have no barring on 
gastrointestinal motility. It is this reviewer’s understanding that “ileus” pertains to gastrointestinal 
motility and not the behavior to seek and ingest intake food. Therefore, decreased food intake does 
not equal ileus, as can be concluded from this manuscripts data on LPS. Although, food intake is not 
an invalid measurement – it is further removed from a direct gastrointestinal transit measurement. 
Hence, mechanistic interpretation becomes difficult. The results presented in this paper confirms 
previously published papers using more direct measures of gastrointestinal motility. 
 Reject because scientifically unsound What next?: 
 Too insignificant to warrant publication in any journal Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
No to all the above. 
None 
Please review this paper.
user
Reviewer's report 
 A conscious mouse model of gastric ileus using clinically relevant endpoints. Title: 
 1  25 October 2004 Version: Date: 
 Anthony J Bauer Reviewer: 
Reviewer's report: 
The article submits the methodological premise that ileus can be equated with food intake (which 
would also result in changes in fecal output). Although, in some experimental models this may be 
experimentally valid many factors contribute to food intake, some of which have no barring on 
gastrointestinal motility. It is this reviewer’s understanding that “ileus” pertains to gastrointestinal 
motility and not the behavior to seek and ingest intake food. Therefore, decreased food intake does 
not equal ileus, as can be concluded from this manuscripts data on LPS. Although, food intake is not 
an invalid measurement – it is further removed from a direct gastrointestinal transit measurement. 
Hence, mechanistic interpretation becomes difficult. The results presented in this paper confirms 
previously published papers using more direct measures of gastrointestinal motility. 
 Reject because scientifically unsound What next?: 
 Too insignificant to warrant publication in any journal Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
No to all the above. 
None 
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