Reviewer's report
Title:Metabonomics analysis of liver tissues in
d-galactosamine/lipopolysaccharide induced acute hepatic failure BALB/c mice
Version: 1Date:16 October 2012
Reviewer: Maria G Roubelakis
Reviewer's report:
The paper by Feng et al describes the metabolomic profile of liver tissues in
d-galactosamime/lipolysaccharide induced acute hepatic failure. The authors
provide a detailed metabolomic characterization of liver tissue, the manuscript is
well written however some improvement is needed.
I recommend the following major comments to be taken into consideration by the
authors:
Major Comments:
Introduction:
The authors should stress better the reason why they why they chose
metabolomic approach for this study and the reason why this can be useful in the
respective disease.
Results-Discussion
1. The authors should also provide more details on the phenotypic characteristics
of the disease (figures or basic characteristics related to the disease such as
transaminases.
2. Metabolic pathways related should be analyzed and expanded.
3. Functional in vitro experiments should be performed, if applicable, to confirm
the identified metabolites and validate the results
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Metabonomics analysis of liver tissues in
d-galactosamine/lipopolysaccharide induced acute hepatic failure BALB/c mice
Version: 1Date:16 October 2012
Reviewer: Maria G Roubelakis
Reviewer's report:
The paper by Feng et al describes the metabolomic profile of liver tissues in
d-galactosamime/lipolysaccharide induced acute hepatic failure. The authors
provide a detailed metabolomic characterization of liver tissue, the manuscript is
well written however some improvement is needed.
I recommend the following major comments to be taken into consideration by the
authors:
Major Comments:
Introduction:
The authors should stress better the reason why they why they chose
metabolomic approach for this study and the reason why this can be useful in the
respective disease.
Results-Discussion
1. The authors should also provide more details on the phenotypic characteristics
of the disease (figures or basic characteristics related to the disease such as
transaminases.
2. Metabolic pathways related should be analyzed and expanded.
3. Functional in vitro experiments should be performed, if applicable, to confirm
the identified metabolites and validate the results
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Metabonomics analysis of liver tissues in
d-galactosamine/lipopolysaccharide induced acute hepatic failure BALB/c mice
Version: 1Date:16 October 2012
Reviewer: Maria G Roubelakis
Reviewer's report:
The paper by Feng et al describes the metabolomic profile of liver tissues in
d-galactosamime/lipolysaccharide induced acute hepatic failure. The authors
provide a detailed metabolomic characterization of liver tissue, the manuscript is
well written however some improvement is needed.
I recommend the following major comments to be taken into consideration by the
authors:
Major Comments:
Introduction:
The authors should stress better the reason why they why they chose
metabolomic approach for this study and the reason why this can be useful in the
respective disease.
Results-Discussion
1. The authors should also provide more details on the phenotypic characteristics
of the disease (figures or basic characteristics related to the disease such as
transaminases.
2. Metabolic pathways related should be analyzed and expanded.
3. Functional in vitro experiments should be performed, if applicable, to confirm
the identified metabolites and validate the results
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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