Title: Potential Predictive Role of Non-HDL to HDL Cholesterol Ratio (NHHR) in MASLD:
Focus on Obese and Type 2 Diabetic Populations
Version: 0 Date: 21 Nov 2024
Reviewer:  Ze-Bin Fang
Reviewer's report:
This manuscript studies the relationship between non-HDL-to-HDL cholesterol ratio (NHHR)
and metabolic function-associated fatty liver disease (MASLD), especially for obese and type 2
diabetic populations, which is innovative and clinically significant. The article has a complete
structure, rigorous data analysis, and clear conclusions. However, there are still some issues that
need to be further supplemented and improved to enhance the scientificity, rigor, and practicality
of the manuscript.
1. The introduction of MASLD and NHHR in the background section is relatively general,
lacking in-depth mechanism discussion.
Can the following content be discussed: How NHHR affects the occurrence and development
of MASLD through mechanisms such as cholesterol metabolism and inflammation? Previous
research results on NHHR and other metabolic-related diseases (such as diabetes and kidney
disease) further highlight the significance of the study.
2. NHANES data have stratified sampling characteristics, but it is not clear whether sample
weights are used for analysis.
3. The NHHR grouping criteria are not explained in detail, which may affect the generalizability
of the results.
4. The literature mentioned in the discussion is insufficiently supported, especially the lack of
research on NHHR in the prediction of MASLD.
5. Some inconsistencies in the results (such as the higher prevalence of MASLD in non-T2D
populations) were not analyzed in depth.
6. The manuscript has important scientific value, but the depth of the background and discussion
sections needs to be supplemented, and the language expression and statistical analysis methods
need to be further optimized.
Title: Potential Predictive Role of Non-HDL to HDL Cholesterol Ratio (NHHR) in MASLD:
Focus on Obese and Type 2 Diabetic Populations
Version: 0 Date: 21 Nov 2024
Reviewer:  Ze-Bin Fang
Reviewer's report:
This manuscript studies the relationship between non-HDL-to-HDL cholesterol ratio (NHHR)
and metabolic function-associated fatty liver disease (MASLD), especially for obese and type 2
diabetic populations, which is innovative and clinically significant. The article has a complete
structure, rigorous data analysis, and clear conclusions. However, there are still some issues that
need to be further supplemented and improved to enhance the scientificity, rigor, and practicality
of the manuscript.
1. The introduction of MASLD and NHHR in the background section is relatively general,
lacking in-depth mechanism discussion.
Can the following content be discussed: How NHHR affects the occurrence and development
of MASLD through mechanisms such as cholesterol metabolism and inflammation? Previous
research results on NHHR and other metabolic-related diseases (such as diabetes and kidney
disease) further highlight the significance of the study.
2. NHANES data have stratified sampling characteristics, but it is not clear whether sample
weights are used for analysis.
3. The NHHR grouping criteria are not explained in detail, which may affect the generalizability
of the results.
4. The literature mentioned in the discussion is insufficiently supported, especially the lack of
research on NHHR in the prediction of MASLD.
5. Some inconsistencies in the results (such as the higher prevalence of MASLD in non-T2D
populations) were not analyzed in depth.
6. The manuscript has important scientific value, but the depth of the background and discussion
sections needs to be supplemented, and the language expression and statistical analysis methods
need to be further optimized.
Please review this paper.
user
Title: Potential Predictive Role of Non-HDL to HDL Cholesterol Ratio (NHHR) in MASLD:
Focus on Obese and Type 2 Diabetic Populations
Version: 0 Date: 21 Nov 2024
Reviewer:  Ze-Bin Fang
Reviewer's report:
This manuscript studies the relationship between non-HDL-to-HDL cholesterol ratio (NHHR)
and metabolic function-associated fatty liver disease (MASLD), especially for obese and type 2
diabetic populations, which is innovative and clinically significant. The article has a complete
structure, rigorous data analysis, and clear conclusions. However, there are still some issues that
need to be further supplemented and improved to enhance the scientificity, rigor, and practicality
of the manuscript.
1. The introduction of MASLD and NHHR in the background section is relatively general,
lacking in-depth mechanism discussion.
Can the following content be discussed: How NHHR affects the occurrence and development
of MASLD through mechanisms such as cholesterol metabolism and inflammation? Previous
research results on NHHR and other metabolic-related diseases (such as diabetes and kidney
disease) further highlight the significance of the study.
2. NHANES data have stratified sampling characteristics, but it is not clear whether sample
weights are used for analysis.
3. The NHHR grouping criteria are not explained in detail, which may affect the generalizability
of the results.
4. The literature mentioned in the discussion is insufficiently supported, especially the lack of
research on NHHR in the prediction of MASLD.
5. Some inconsistencies in the results (such as the higher prevalence of MASLD in non-T2D
populations) were not analyzed in depth.
6. The manuscript has important scientific value, but the depth of the background and discussion
sections needs to be supplemented, and the language expression and statistical analysis methods
need to be further optimized.
assistant