Title: Development and validation of a clinical prediction model for the risk of distal metastasis
in intrahepatic cholangiocarcinoma: a real-world study
Version: 1 Date: 30 Oct 2023
Reviewer's report:
1. This retrospective study  had divided 345  CCA patients into two groups, in which there
were only 21 cases of distal metastases, and 324 cases were non-distal metastases, groupings
may have a large statistical bias. please explain the rationale for such a grouping. Adjusting the
proportions of the two groups would better avoid statistical bias.
2. How to validate the model established by the study? Please validate the model with additional
data.
Title: Development and validation of a clinical prediction model for the risk of distal metastasis
in intrahepatic cholangiocarcinoma: a real-world study
Version: 1 Date: 30 Oct 2023
Reviewer's report:
1. This retrospective study  had divided 345  CCA patients into two groups, in which there
were only 21 cases of distal metastases, and 324 cases were non-distal metastases, groupings
may have a large statistical bias. please explain the rationale for such a grouping. Adjusting the
proportions of the two groups would better avoid statistical bias.
2. How to validate the model established by the study? Please validate the model with additional
data.
Please review this paper.
user
Title: Development and validation of a clinical prediction model for the risk of distal metastasis
in intrahepatic cholangiocarcinoma: a real-world study
Version: 1 Date: 30 Oct 2023
Reviewer's report:
1. This retrospective study  had divided 345  CCA patients into two groups, in which there
were only 21 cases of distal metastases, and 324 cases were non-distal metastases, groupings
may have a large statistical bias. please explain the rationale for such a grouping. Adjusting the
proportions of the two groups would better avoid statistical bias.
2. How to validate the model established by the study? Please validate the model with additional
data.
assistant