Title: Risk factors for endoscopic postoperative recurrence in patients with Crohn's Disease:A
protocol for systematic review and meta-analysis
Version: 1 Date: 02 Apr 2024
Reviewer's report:
The authors submit their original work in the form of a systematic review and meta analysis
investigating the risk factors for postoperative recurrence of endoscopy after initial surgical
intervention for patients with Crohn’s disease. The authors conclude that multiple risk factors
and postoperative prophylactic medication as a protective factor. However, there are still limited
published work at this time.
I would like to thank the authors for their hard work on submitting this manuscript to BMC
Gastroenterology and I enjoyed reading their outcomes. Their hard work is admirable. While I
do think the current work may be worthy of publication as this type of comparison has never
been done before based on my literature search, I would recommend the authors address the
minor issues listed below before further consideration.
Methods:
In the inclusion criteria, the authors write “…(2) the exposure group was CD patients with
ePOR.” How did they define ePOR? Please clarify if it was at anytime an endoscopy procedure
was done after initial surgical intervention.
I would highly recommend the authors use NIS study quality assessment tool: https://
www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools instead of NOS for quality of
studies rating.
Discussion:
I agree with the limitations mentioned. Please also mention lack of controlling confounders in
your meta-analysis that is subject to control from the original studies.
Other minor edits
Can the authors check that the entire manuscript be written in the past tense?
Again, I applaud the authors for their hard work. I look forward to reading the revised
manuscript.
Title: Risk factors for endoscopic postoperative recurrence in patients with Crohn's Disease:A
protocol for systematic review and meta-analysis
Version: 1 Date: 02 Apr 2024
Reviewer's report:
The authors submit their original work in the form of a systematic review and meta analysis
investigating the risk factors for postoperative recurrence of endoscopy after initial surgical
intervention for patients with Crohn’s disease. The authors conclude that multiple risk factors
and postoperative prophylactic medication as a protective factor. However, there are still limited
published work at this time.
I would like to thank the authors for their hard work on submitting this manuscript to BMC
Gastroenterology and I enjoyed reading their outcomes. Their hard work is admirable. While I
do think the current work may be worthy of publication as this type of comparison has never
been done before based on my literature search, I would recommend the authors address the
minor issues listed below before further consideration.
Methods:
In the inclusion criteria, the authors write “…(2) the exposure group was CD patients with
ePOR.” How did they define ePOR? Please clarify if it was at anytime an endoscopy procedure
was done after initial surgical intervention.
I would highly recommend the authors use NIS study quality assessment tool: https://
www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools instead of NOS for quality of
studies rating.
Discussion:
I agree with the limitations mentioned. Please also mention lack of controlling confounders in
your meta-analysis that is subject to control from the original studies.
Other minor edits
Can the authors check that the entire manuscript be written in the past tense?
Again, I applaud the authors for their hard work. I look forward to reading the revised
manuscript.
Please review this paper.
user
Title: Risk factors for endoscopic postoperative recurrence in patients with Crohn's Disease:A
protocol for systematic review and meta-analysis
Version: 1 Date: 02 Apr 2024
Reviewer's report:
The authors submit their original work in the form of a systematic review and meta analysis
investigating the risk factors for postoperative recurrence of endoscopy after initial surgical
intervention for patients with Crohn’s disease. The authors conclude that multiple risk factors
and postoperative prophylactic medication as a protective factor. However, there are still limited
published work at this time.
I would like to thank the authors for their hard work on submitting this manuscript to BMC
Gastroenterology and I enjoyed reading their outcomes. Their hard work is admirable. While I
do think the current work may be worthy of publication as this type of comparison has never
been done before based on my literature search, I would recommend the authors address the
minor issues listed below before further consideration.
Methods:
In the inclusion criteria, the authors write “…(2) the exposure group was CD patients with
ePOR.” How did they define ePOR? Please clarify if it was at anytime an endoscopy procedure
was done after initial surgical intervention.
I would highly recommend the authors use NIS study quality assessment tool: https://
www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools instead of NOS for quality of
studies rating.
Discussion:
I agree with the limitations mentioned. Please also mention lack of controlling confounders in
your meta-analysis that is subject to control from the original studies.
Other minor edits
Can the authors check that the entire manuscript be written in the past tense?
Again, I applaud the authors for their hard work. I look forward to reading the revised
manuscript.
assistant