Reviewer's report
Title:Ulcerative Jejunitis in a Child with Celiac Disease
Version: 2Date:22 May 2013
Reviewer: Decker Butzner
Reviewer's report:
Sigman, etal. have provided and informative case report of a 9 year old child who
presented with IGA deficiency, likely celiac disease and ulcerative jejunitis. This
is an unusual unique presentation in a child.
Comments: All minor and can be addressed by the authors
1) In the case history comments on the use of NSAIDS and results of serial
celiac serology testing and IgA testing would add clarity to the report. Did the IgA
deficiency correct over time and did the positive anti-endomysial antibody
normalize? What were the antibody levels at each time point? Please include the
length of time between the upper endoscopy and the 2nd endoscopy. What was
the technique of the 2nd endoscopy? Ped colonscope, push technique, double
balloon?
2) Added discussion on the differential diagnosis of ulcerative jejunitis in children
including aquired immunodeficiency syndrome, NSAID use, HSP, eosinophillic
gastroenteritis, recurrent intussusception and Crohn disease as a minimum. This
is such a rare condition in pediatrics, a discussion of the differential would be
appreciated to help a clinician faced with this. The authors should also include
the small case series about ulcerative jejunitis, (3of 4 were NSAID related) with
capsule exams in children (Fritscher-Ravens A. Gut. 2009; 58: 1467-72).
Increased IEL's seen with Crohn and perhaps NSAIDS.
3) There are a few abbreviations such as RCD and EATL that are not defined.
This confuses international readers and all abbreviations should be defined.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Ulcerative Jejunitis in a Child with Celiac Disease
Version: 2Date:22 May 2013
Reviewer: Decker Butzner
Reviewer's report:
Sigman, etal. have provided and informative case report of a 9 year old child who
presented with IGA deficiency, likely celiac disease and ulcerative jejunitis. This
is an unusual unique presentation in a child.
Comments: All minor and can be addressed by the authors
1) In the case history comments on the use of NSAIDS and results of serial
celiac serology testing and IgA testing would add clarity to the report. Did the IgA
deficiency correct over time and did the positive anti-endomysial antibody
normalize? What were the antibody levels at each time point? Please include the
length of time between the upper endoscopy and the 2nd endoscopy. What was
the technique of the 2nd endoscopy? Ped colonscope, push technique, double
balloon?
2) Added discussion on the differential diagnosis of ulcerative jejunitis in children
including aquired immunodeficiency syndrome, NSAID use, HSP, eosinophillic
gastroenteritis, recurrent intussusception and Crohn disease as a minimum. This
is such a rare condition in pediatrics, a discussion of the differential would be
appreciated to help a clinician faced with this. The authors should also include
the small case series about ulcerative jejunitis, (3of 4 were NSAID related) with
capsule exams in children (Fritscher-Ravens A. Gut. 2009; 58: 1467-72).
Increased IEL's seen with Crohn and perhaps NSAIDS.
3) There are a few abbreviations such as RCD and EATL that are not defined.
This confuses international readers and all abbreviations should be defined.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Ulcerative Jejunitis in a Child with Celiac Disease
Version: 2Date:22 May 2013
Reviewer: Decker Butzner
Reviewer's report:
Sigman, etal. have provided and informative case report of a 9 year old child who
presented with IGA deficiency, likely celiac disease and ulcerative jejunitis. This
is an unusual unique presentation in a child.
Comments: All minor and can be addressed by the authors
1) In the case history comments on the use of NSAIDS and results of serial
celiac serology testing and IgA testing would add clarity to the report. Did the IgA
deficiency correct over time and did the positive anti-endomysial antibody
normalize? What were the antibody levels at each time point? Please include the
length of time between the upper endoscopy and the 2nd endoscopy. What was
the technique of the 2nd endoscopy? Ped colonscope, push technique, double
balloon?
2) Added discussion on the differential diagnosis of ulcerative jejunitis in children
including aquired immunodeficiency syndrome, NSAID use, HSP, eosinophillic
gastroenteritis, recurrent intussusception and Crohn disease as a minimum. This
is such a rare condition in pediatrics, a discussion of the differential would be
appreciated to help a clinician faced with this. The authors should also include
the small case series about ulcerative jejunitis, (3of 4 were NSAID related) with
capsule exams in children (Fritscher-Ravens A. Gut. 2009; 58: 1467-72).
Increased IEL's seen with Crohn and perhaps NSAIDS.
3) There are a few abbreviations such as RCD and EATL that are not defined.
This confuses international readers and all abbreviations should be defined.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant