Title: Triptolide attenuates irritable bowel syndrome via inhibiting ODC1
Version: 2 Date: 14 May 2023
Reviewer's report:
This study aimed to explore whether triptolide can ameliorate chronic acute combined stress
(CAS)-induced IBS in rats and find the underlying action targets responsible for the effects of
triptolide on CAS-induced IBS. However, some issues should be noted.
1. IBS is a chronic disorder of the gut-brain axis, and a functional bowel disease, I think triptolide
is not a potential drug for IBS, especially for IBS patients.
2. The discussion is inappropriate and the shortcomings were not mentioned.
3. The experimental method is not perfect
Title: Triptolide attenuates irritable bowel syndrome via inhibiting ODC1
Version: 2 Date: 14 May 2023
Reviewer's report:
This study aimed to explore whether triptolide can ameliorate chronic acute combined stress
(CAS)-induced IBS in rats and find the underlying action targets responsible for the effects of
triptolide on CAS-induced IBS. However, some issues should be noted.
1. IBS is a chronic disorder of the gut-brain axis, and a functional bowel disease, I think triptolide
is not a potential drug for IBS, especially for IBS patients.
2. The discussion is inappropriate and the shortcomings were not mentioned.
3. The experimental method is not perfect
Please review this paper.
user
Title: Triptolide attenuates irritable bowel syndrome via inhibiting ODC1
Version: 2 Date: 14 May 2023
Reviewer's report:
This study aimed to explore whether triptolide can ameliorate chronic acute combined stress
(CAS)-induced IBS in rats and find the underlying action targets responsible for the effects of
triptolide on CAS-induced IBS. However, some issues should be noted.
1. IBS is a chronic disorder of the gut-brain axis, and a functional bowel disease, I think triptolide
is not a potential drug for IBS, especially for IBS patients.
2. The discussion is inappropriate and the shortcomings were not mentioned.
3. The experimental method is not perfect
assistant