Title: Multicentre prospective study to evaluate effectiveness and safety of gel-forming
and hyaluronic-acid containing chewable tablets as add-on treatment in patients with
gastroesophageal reflux disease (GERD) symptoms and unsatisfying proton pump inhibitor
therapy.
Version: 1 Date: 28 Jun 2023
Reviewer's report:
Thank you for your revision.
I only have several more comments:
1.  Introduction:
The pathophysiology behind this disorder is complex (5). However, the reflux of acidic stomach
content up the esophagus towards the mouth is the most important factor (1, 6).
The above statement did not appear to reflect the pathophysiology of GERD. Please explain
briefly in a  more specific, scientific and clinical way.
2. Sobrade® chewable tablet is a preparation with a solely physical mode of action and classified
as a medical device of lowest risk (Class 1).
There should be some references that can be cite in order to understand more of the content and
support the 'device'. ? from the approved official National Pharmaceutical Regulatory Agency?
Any reference for the essential active ingredient that has studied before for GERD? in vivo?
in vitro?
Title: Multicentre prospective study to evaluate effectiveness and safety of gel-forming
and hyaluronic-acid containing chewable tablets as add-on treatment in patients with
gastroesophageal reflux disease (GERD) symptoms and unsatisfying proton pump inhibitor
therapy.
Version: 1 Date: 28 Jun 2023
Reviewer's report:
Thank you for your revision.
I only have several more comments:
1.  Introduction:
The pathophysiology behind this disorder is complex (5). However, the reflux of acidic stomach
content up the esophagus towards the mouth is the most important factor (1, 6).
The above statement did not appear to reflect the pathophysiology of GERD. Please explain
briefly in a  more specific, scientific and clinical way.
2. Sobrade® chewable tablet is a preparation with a solely physical mode of action and classified
as a medical device of lowest risk (Class 1).
There should be some references that can be cite in order to understand more of the content and
support the 'device'. ? from the approved official National Pharmaceutical Regulatory Agency?
Any reference for the essential active ingredient that has studied before for GERD? in vivo?
in vitro?
Please review this paper.
user
Title: Multicentre prospective study to evaluate effectiveness and safety of gel-forming
and hyaluronic-acid containing chewable tablets as add-on treatment in patients with
gastroesophageal reflux disease (GERD) symptoms and unsatisfying proton pump inhibitor
therapy.
Version: 1 Date: 28 Jun 2023
Reviewer's report:
Thank you for your revision.
I only have several more comments:
1.  Introduction:
The pathophysiology behind this disorder is complex (5). However, the reflux of acidic stomach
content up the esophagus towards the mouth is the most important factor (1, 6).
The above statement did not appear to reflect the pathophysiology of GERD. Please explain
briefly in a  more specific, scientific and clinical way.
2. Sobrade® chewable tablet is a preparation with a solely physical mode of action and classified
as a medical device of lowest risk (Class 1).
There should be some references that can be cite in order to understand more of the content and
support the 'device'. ? from the approved official National Pharmaceutical Regulatory Agency?
Any reference for the essential active ingredient that has studied before for GERD? in vivo?
in vitro?
assistant