Title: The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis
Version: 4 Date: 10 Sep 2024
Reviewer's report:
Dear Editor,
I should first thank for inviting me as potential reviewer to read and comment on paper entitled
‘’The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis’’.
In the current study, the authors aimed to estimate the prevalence of obesity, overweight, and
underweight in celiac disease (CD) at diagnosis before starting the gluten-free diet.
The main title accurately reflects the major topic and content of the study.
The abstract summarizes and reflects the work described in the manuscript. Also, the abstract
presents the significant points related to the background, objectives, materials and methods,
results and conclusions.
The materials and methods sufficiently described for the results and conclusions that are
presented in the preceding sections. The study type and design were defined in the section of
the materials and methods. Inclusion and exclusion criteria are well defined. Figures and tables
are sufficient and well-organized.
The section of the discussion is well organized. The conclusions are drawn appropriately
supported by the literature. The manuscript adequately describes the background, present
status and significance of the study. The manuscript interprets the findings adequately and
appropriately, highlighting the key points clearly.
I think that it will contribute to the literature. I have some minor criticisms.
- The Introduction part of the manuscript appropriately cites the important and authoritative
references but does not cite the recent published articles. Especially at the following sentences,
if the recent published articles about celiac disease and autoimmune disease for example ‘’ Eur
J Rheumatol. 2019 Apr 22;6(3):142-145. Serological screening for celiac disease in children
with systemic lupus erythematosus’’,  ‘’Arab J Gastroenterol. 2019 Jun;20(2):95-98. Serological
screening for coeliac disease in patients with juvenile idiopathic arthritis’’, ‘’Acta Gastroenterol
Belg. 2018 Jan-Mar;81(1):5-8. The frequency of celiac disease in children with autoimmune
thyroiditis’’ are cited, the manuscript would be better.
- Especially at the following sentence, if the recent published articles about that ‘’Clinical
evaluation of children with celiac disease: A single-center experience. Arch Clin Gastroenterol
6(2): 026-030. DOI: https://dx.doi.org/10.17352/2455-2283.000074’’
#s cited, it would be better. In that article conducted in Turkey, underweight was detected in
29 patients (47.5%).
‘’Although the prevalence of underweight among CD patients in developed countries was
approximately less than 10%, in developing countries, overweight and obesity are considered
rare symptoms of CD at the time of diagnosis; for instance, in India, 36%-42% of CD patients
were underweight [5, 32]’’
Title: The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis
Version: 4 Date: 10 Sep 2024
Reviewer's report:
Dear Editor,
I should first thank for inviting me as potential reviewer to read and comment on paper entitled
‘’The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis’’.
In the current study, the authors aimed to estimate the prevalence of obesity, overweight, and
underweight in celiac disease (CD) at diagnosis before starting the gluten-free diet.
The main title accurately reflects the major topic and content of the study.
The abstract summarizes and reflects the work described in the manuscript. Also, the abstract
presents the significant points related to the background, objectives, materials and methods,
results and conclusions.
The materials and methods sufficiently described for the results and conclusions that are
presented in the preceding sections. The study type and design were defined in the section of
the materials and methods. Inclusion and exclusion criteria are well defined. Figures and tables
are sufficient and well-organized.
The section of the discussion is well organized. The conclusions are drawn appropriately
supported by the literature. The manuscript adequately describes the background, present
status and significance of the study. The manuscript interprets the findings adequately and
appropriately, highlighting the key points clearly.
I think that it will contribute to the literature. I have some minor criticisms.
- The Introduction part of the manuscript appropriately cites the important and authoritative
references but does not cite the recent published articles. Especially at the following sentences,
if the recent published articles about celiac disease and autoimmune disease for example ‘’ Eur
J Rheumatol. 2019 Apr 22;6(3):142-145. Serological screening for celiac disease in children
with systemic lupus erythematosus’’,  ‘’Arab J Gastroenterol. 2019 Jun;20(2):95-98. Serological
screening for coeliac disease in patients with juvenile idiopathic arthritis’’, ‘’Acta Gastroenterol
Belg. 2018 Jan-Mar;81(1):5-8. The frequency of celiac disease in children with autoimmune
thyroiditis’’ are cited, the manuscript would be better.
- Especially at the following sentence, if the recent published articles about that ‘’Clinical
evaluation of children with celiac disease: A single-center experience. Arch Clin Gastroenterol
6(2): 026-030. DOI: https://dx.doi.org/10.17352/2455-2283.000074’’
#s cited, it would be better. In that article conducted in Turkey, underweight was detected in
29 patients (47.5%).
‘’Although the prevalence of underweight among CD patients in developed countries was
approximately less than 10%, in developing countries, overweight and obesity are considered
rare symptoms of CD at the time of diagnosis; for instance, in India, 36%-42% of CD patients
were underweight [5, 32]’’
Please review this paper.
user
Title: The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis
Version: 4 Date: 10 Sep 2024
Reviewer's report:
Dear Editor,
I should first thank for inviting me as potential reviewer to read and comment on paper entitled
‘’The prevalence of obesity and underweight in celiac patients at the time of diagnosis: a
systematic review and meta-analysis’’.
In the current study, the authors aimed to estimate the prevalence of obesity, overweight, and
underweight in celiac disease (CD) at diagnosis before starting the gluten-free diet.
The main title accurately reflects the major topic and content of the study.
The abstract summarizes and reflects the work described in the manuscript. Also, the abstract
presents the significant points related to the background, objectives, materials and methods,
results and conclusions.
The materials and methods sufficiently described for the results and conclusions that are
presented in the preceding sections. The study type and design were defined in the section of
the materials and methods. Inclusion and exclusion criteria are well defined. Figures and tables
are sufficient and well-organized.
The section of the discussion is well organized. The conclusions are drawn appropriately
supported by the literature. The manuscript adequately describes the background, present
status and significance of the study. The manuscript interprets the findings adequately and
appropriately, highlighting the key points clearly.
I think that it will contribute to the literature. I have some minor criticisms.
- The Introduction part of the manuscript appropriately cites the important and authoritative
references but does not cite the recent published articles. Especially at the following sentences,
if the recent published articles about celiac disease and autoimmune disease for example ‘’ Eur
J Rheumatol. 2019 Apr 22;6(3):142-145. Serological screening for celiac disease in children
with systemic lupus erythematosus’’,  ‘’Arab J Gastroenterol. 2019 Jun;20(2):95-98. Serological
screening for coeliac disease in patients with juvenile idiopathic arthritis’’, ‘’Acta Gastroenterol
Belg. 2018 Jan-Mar;81(1):5-8. The frequency of celiac disease in children with autoimmune
thyroiditis’’ are cited, the manuscript would be better.
- Especially at the following sentence, if the recent published articles about that ‘’Clinical
evaluation of children with celiac disease: A single-center experience. Arch Clin Gastroenterol
6(2): 026-030. DOI: https://dx.doi.org/10.17352/2455-2283.000074’’
#s cited, it would be better. In that article conducted in Turkey, underweight was detected in
29 patients (47.5%).
‘’Although the prevalence of underweight among CD patients in developed countries was
approximately less than 10%, in developing countries, overweight and obesity are considered
rare symptoms of CD at the time of diagnosis; for instance, in India, 36%-42% of CD patients
were underweight [5, 32]’’
assistant