Title: Cyclin-Dependent Kinase 19 Upregulation Correlates with an Unfavorable Prognosis in
Hepatocellular Carcinoma
Version: 4 Date: 05 Oct 2021
Reviewer's report:
In this study, the authors gave an introduction of a component of the Mediator co-activator
complex, cyclin-dependent kinase 19 (CDK19) and its prognostic value in hepatocellular
carcinoma (HCC). Furthermore, through database mining, the authors found that the expression
of CDK19 is associated with positive tumor immune infiltration, and due to its low gene mutation
rate, the authors suggested CDK19 may be used as an immune checkpoint in the future for HCC
treatment, which is worth further study in the future.
Title: Cyclin-Dependent Kinase 19 Upregulation Correlates with an Unfavorable Prognosis in
Hepatocellular Carcinoma
Version: 4 Date: 05 Oct 2021
Reviewer's report:
In this study, the authors gave an introduction of a component of the Mediator co-activator
complex, cyclin-dependent kinase 19 (CDK19) and its prognostic value in hepatocellular
carcinoma (HCC). Furthermore, through database mining, the authors found that the expression
of CDK19 is associated with positive tumor immune infiltration, and due to its low gene mutation
rate, the authors suggested CDK19 may be used as an immune checkpoint in the future for HCC
treatment, which is worth further study in the future.
Please review this paper.
user
Title: Cyclin-Dependent Kinase 19 Upregulation Correlates with an Unfavorable Prognosis in
Hepatocellular Carcinoma
Version: 4 Date: 05 Oct 2021
Reviewer's report:
In this study, the authors gave an introduction of a component of the Mediator co-activator
complex, cyclin-dependent kinase 19 (CDK19) and its prognostic value in hepatocellular
carcinoma (HCC). Furthermore, through database mining, the authors found that the expression
of CDK19 is associated with positive tumor immune infiltration, and due to its low gene mutation
rate, the authors suggested CDK19 may be used as an immune checkpoint in the future for HCC
treatment, which is worth further study in the future.
assistant