Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 1 Date: 01 Sep 2024
Reviewer's report:
Thanks for this article.
I think you have emphasisized that the objective was to distinguish between non perforated and
perforated appendicitis in the preoperative setting.
1.  It would be good if you can also mention the surgical access used in both these groups
of patients.  Was it possible to operate onthe perforated cases through a Right lower quadrant
incision or did they all need a midline laparotomy?
2. Did the preoperative  imaging studies corelate with the operative findings ?
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 1 Date: 01 Sep 2024
Reviewer's report:
Thanks for this article.
I think you have emphasisized that the objective was to distinguish between non perforated and
perforated appendicitis in the preoperative setting.
1.  It would be good if you can also mention the surgical access used in both these groups
of patients.  Was it possible to operate onthe perforated cases through a Right lower quadrant
incision or did they all need a midline laparotomy?
2. Did the preoperative  imaging studies corelate with the operative findings ?
Please review this paper.
user
Title: 5-Hydroxyindoleacetic Acid as a biomarker for revealing perforation in acute appendicitis
Version: 1 Date: 01 Sep 2024
Reviewer's report:
Thanks for this article.
I think you have emphasisized that the objective was to distinguish between non perforated and
perforated appendicitis in the preoperative setting.
1.  It would be good if you can also mention the surgical access used in both these groups
of patients.  Was it possible to operate onthe perforated cases through a Right lower quadrant
incision or did they all need a midline laparotomy?
2. Did the preoperative  imaging studies corelate with the operative findings ?
assistant