Title: RARB associated with MSI, affects progression and prognosis of gastric cancer
Version: 7 Date: 13 May 2024
Reviewer's report:
The study utilized bioinformatics methods to identify the core gene RARB, followed by multiple
experimental validations of its expression and regulatory mechanisms in gastric cancer. The
authors employed bioinformatics approaches to screen for this gene and investigate associated
metabolic pathways. They validated expression levels by collecting relevant patient samples.
Knocking down RARB was found to increase expression levels and metastasis in gastric cancer
cells. Additionally, knocking down RARB was observed to reduce the expression levels of
the EMT-related protein E-cadherin. Finally, the clinical prognosis and immune prognostic
relevance of RARB in gastric cancer were studied. The article comprehensively investigates
the mechanisms associated with RARB in gastric cancer, demonstrating a thorough and well-
designed study deserving of acceptance.
Title: RARB associated with MSI, affects progression and prognosis of gastric cancer
Version: 7 Date: 13 May 2024
Reviewer's report:
The study utilized bioinformatics methods to identify the core gene RARB, followed by multiple
experimental validations of its expression and regulatory mechanisms in gastric cancer. The
authors employed bioinformatics approaches to screen for this gene and investigate associated
metabolic pathways. They validated expression levels by collecting relevant patient samples.
Knocking down RARB was found to increase expression levels and metastasis in gastric cancer
cells. Additionally, knocking down RARB was observed to reduce the expression levels of
the EMT-related protein E-cadherin. Finally, the clinical prognosis and immune prognostic
relevance of RARB in gastric cancer were studied. The article comprehensively investigates
the mechanisms associated with RARB in gastric cancer, demonstrating a thorough and well-
designed study deserving of acceptance.
Please review this paper.
user
Title: RARB associated with MSI, affects progression and prognosis of gastric cancer
Version: 7 Date: 13 May 2024
Reviewer's report:
The study utilized bioinformatics methods to identify the core gene RARB, followed by multiple
experimental validations of its expression and regulatory mechanisms in gastric cancer. The
authors employed bioinformatics approaches to screen for this gene and investigate associated
metabolic pathways. They validated expression levels by collecting relevant patient samples.
Knocking down RARB was found to increase expression levels and metastasis in gastric cancer
cells. Additionally, knocking down RARB was observed to reduce the expression levels of
the EMT-related protein E-cadherin. Finally, the clinical prognosis and immune prognostic
relevance of RARB in gastric cancer were studied. The article comprehensively investigates
the mechanisms associated with RARB in gastric cancer, demonstrating a thorough and well-
designed study deserving of acceptance.
assistant