Reviewer's report
Title:Cognitive-behavioural therapy has no effect on disease activity but
improves quality of life in subgroups of patients with inflammatory bowel disease:
A pilot randomised controlled trial
Version:2Date:1 February 2015
Reviewer: mathurin fumery
Reviewer's report:
Major Compulsory Revisons
Materials/methods
- Could you defined "clinically established diagnosis of IBD" (page 7)?
- Can you explain why current psychiatric/antidepressant therapy are not
exclusion criteria?
Results
- Primary outcome: Have you performed an "intention to treat" analysis?
Figures
Figure 1: Page 13-in flow chart, 92 patients were allocated to intervention.
However, in the manuscript, 90 patients underwent CBT.
References
Please complete references 17 and 19
Minor Essential Revisisons
Materials and methods
- How have you decided the optimal duration of CBT? Do you think that negative
results on the primary endpoint could be explain by a too short duration of CBT.
-Could you explain more precisely in methods the difference between F2F CBT
and CBT?
Results
-Please defined 'in need group' in "materials and methods" and not in "results"
(page 13)
Results
- Your results are adjusted for baseline. Could you explain on which variables at
baseline do you perfomed this adjustment? (disease activity?associated
therapy?)
- We observed important lost of follow up in CBT group (superior to control
group). It could be explain by the difficulty to observe correctly CBT. Can you
discuss this point? Did you observed associated factor to CBT non observance?
- Did you observed difference of associated conventionnal IBD managment
between the CBT and controls groups?
Discretionary Revisions
Results:
Comment : No data where available on endoscopic activity. it is well known that a
large number of IBD patients have clinical symptoms without any endoscopic
lesion (IBS..). It would be very interesting to have results in these different
subgroup of patients.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interest
Reviewer's report
Title:Cognitive-behavioural therapy has no effect on disease activity but
improves quality of life in subgroups of patients with inflammatory bowel disease:
A pilot randomised controlled trial
Version:2Date:1 February 2015
Reviewer: mathurin fumery
Reviewer's report:
Major Compulsory Revisons
Materials/methods
- Could you defined "clinically established diagnosis of IBD" (page 7)?
- Can you explain why current psychiatric/antidepressant therapy are not
exclusion criteria?
Results
- Primary outcome: Have you performed an "intention to treat" analysis?
Figures
Figure 1: Page 13-in flow chart, 92 patients were allocated to intervention.
However, in the manuscript, 90 patients underwent CBT.
References
Please complete references 17 and 19
Minor Essential Revisisons
Materials and methods
- How have you decided the optimal duration of CBT? Do you think that negative
results on the primary endpoint could be explain by a too short duration of CBT.
-Could you explain more precisely in methods the difference between F2F CBT
and CBT?
Results
-Please defined 'in need group' in "materials and methods" and not in "results"
(page 13)
Results
- Your results are adjusted for baseline. Could you explain on which variables at
baseline do you perfomed this adjustment? (disease activity?associated
therapy?)
- We observed important lost of follow up in CBT group (superior to control
group). It could be explain by the difficulty to observe correctly CBT. Can you
discuss this point? Did you observed associated factor to CBT non observance?
- Did you observed difference of associated conventionnal IBD managment
between the CBT and controls groups?
Discretionary Revisions
Results:
Comment : No data where available on endoscopic activity. it is well known that a
large number of IBD patients have clinical symptoms without any endoscopic
lesion (IBS..). It would be very interesting to have results in these different
subgroup of patients.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interest
Please review this paper.
user
Reviewer's report
Title:Cognitive-behavioural therapy has no effect on disease activity but
improves quality of life in subgroups of patients with inflammatory bowel disease:
A pilot randomised controlled trial
Version:2Date:1 February 2015
Reviewer: mathurin fumery
Reviewer's report:
Major Compulsory Revisons
Materials/methods
- Could you defined "clinically established diagnosis of IBD" (page 7)?
- Can you explain why current psychiatric/antidepressant therapy are not
exclusion criteria?
Results
- Primary outcome: Have you performed an "intention to treat" analysis?
Figures
Figure 1: Page 13-in flow chart, 92 patients were allocated to intervention.
However, in the manuscript, 90 patients underwent CBT.
References
Please complete references 17 and 19
Minor Essential Revisisons
Materials and methods
- How have you decided the optimal duration of CBT? Do you think that negative
results on the primary endpoint could be explain by a too short duration of CBT.
-Could you explain more precisely in methods the difference between F2F CBT
and CBT?
Results
-Please defined 'in need group' in "materials and methods" and not in "results"
(page 13)
Results
- Your results are adjusted for baseline. Could you explain on which variables at
baseline do you perfomed this adjustment? (disease activity?associated
therapy?)
- We observed important lost of follow up in CBT group (superior to control
group). It could be explain by the difficulty to observe correctly CBT. Can you
discuss this point? Did you observed associated factor to CBT non observance?
- Did you observed difference of associated conventionnal IBD managment
between the CBT and controls groups?
Discretionary Revisions
Results:
Comment : No data where available on endoscopic activity. it is well known that a
large number of IBD patients have clinical symptoms without any endoscopic
lesion (IBS..). It would be very interesting to have results in these different
subgroup of patients.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interest
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