Reviewer's report
Title:Correlation between the methylation of SULF2 and WRN promoter and the
irinotecan chemosensitivity in gastric cancer
Version: 4Date:23 September 2013
Reviewer: Mathewos Tessema
Reviewer's report:
The revised manuscript addressed most of the comments raised in the previous
review. However, despite the authors’ best effort, the manuscript remains poorly
written. Also, a critical experiment that was recommended to significantly improve
the conclusion and impact of the manuscript is left as a future plan. Thus, I
recommend the following before it is considered for publication.
1. Evaluate expression of ISG15, compare its level between sensitive and
resistant groups, and discussion the results in comparison with previous studies.
2. Use professional help to improve the language.
3. New figure 3 is taken without any modification from a published article. Since
the paper is already cited, its inclusion seems unnecessary and may require
permission from the previous publisher.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Correlation between the methylation of SULF2 and WRN promoter and the
irinotecan chemosensitivity in gastric cancer
Version: 4Date:23 September 2013
Reviewer: Mathewos Tessema
Reviewer's report:
The revised manuscript addressed most of the comments raised in the previous
review. However, despite the authors’ best effort, the manuscript remains poorly
written. Also, a critical experiment that was recommended to significantly improve
the conclusion and impact of the manuscript is left as a future plan. Thus, I
recommend the following before it is considered for publication.
1. Evaluate expression of ISG15, compare its level between sensitive and
resistant groups, and discussion the results in comparison with previous studies.
2. Use professional help to improve the language.
3. New figure 3 is taken without any modification from a published article. Since
the paper is already cited, its inclusion seems unnecessary and may require
permission from the previous publisher.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Correlation between the methylation of SULF2 and WRN promoter and the
irinotecan chemosensitivity in gastric cancer
Version: 4Date:23 September 2013
Reviewer: Mathewos Tessema
Reviewer's report:
The revised manuscript addressed most of the comments raised in the previous
review. However, despite the authors’ best effort, the manuscript remains poorly
written. Also, a critical experiment that was recommended to significantly improve
the conclusion and impact of the manuscript is left as a future plan. Thus, I
recommend the following before it is considered for publication.
1. Evaluate expression of ISG15, compare its level between sensitive and
resistant groups, and discussion the results in comparison with previous studies.
2. Use professional help to improve the language.
3. New figure 3 is taken without any modification from a published article. Since
the paper is already cited, its inclusion seems unnecessary and may require
permission from the previous publisher.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant