Title: Linoleic acid pathway disturbance contributing to potential cancerization of intrahepatic
bile duct stones into intrahepatic cholangiocarcinoma
Version: 0 Date: 14 Apr 2022
Reviewer's report:
In the present manuscript, Li, J., et al. first demonstrated the aberrant of linoleic acid pathway
in intrahepatic cholangiocarcinoma (ICC) and intrahepatic bile duct stone (IBDS). The levels
of total metabolites in ICC and IBDS were determined using GC-MS based metabolomics.
In addition, the correlation between key metabolite and clinical features of patients were also
investigated. The different pattern in in linoleic acid metabolism pathway between IBDS and
ICC were observed. The experiments were performed in a technically sound manner. The
overall idea presented has merit. This manuscript is good enough for publishing in BMC
Gastroenterology.
Title: Linoleic acid pathway disturbance contributing to potential cancerization of intrahepatic
bile duct stones into intrahepatic cholangiocarcinoma
Version: 0 Date: 14 Apr 2022
Reviewer's report:
In the present manuscript, Li, J., et al. first demonstrated the aberrant of linoleic acid pathway
in intrahepatic cholangiocarcinoma (ICC) and intrahepatic bile duct stone (IBDS). The levels
of total metabolites in ICC and IBDS were determined using GC-MS based metabolomics.
In addition, the correlation between key metabolite and clinical features of patients were also
investigated. The different pattern in in linoleic acid metabolism pathway between IBDS and
ICC were observed. The experiments were performed in a technically sound manner. The
overall idea presented has merit. This manuscript is good enough for publishing in BMC
Gastroenterology.
Please review this paper.
user
Title: Linoleic acid pathway disturbance contributing to potential cancerization of intrahepatic
bile duct stones into intrahepatic cholangiocarcinoma
Version: 0 Date: 14 Apr 2022
Reviewer's report:
In the present manuscript, Li, J., et al. first demonstrated the aberrant of linoleic acid pathway
in intrahepatic cholangiocarcinoma (ICC) and intrahepatic bile duct stone (IBDS). The levels
of total metabolites in ICC and IBDS were determined using GC-MS based metabolomics.
In addition, the correlation between key metabolite and clinical features of patients were also
investigated. The different pattern in in linoleic acid metabolism pathway between IBDS and
ICC were observed. The experiments were performed in a technically sound manner. The
overall idea presented has merit. This manuscript is good enough for publishing in BMC
Gastroenterology.
assistant