Reviewer ’s report  
 
Title: Refractoriness to subcutaneous implantable cardiovert er defibrillator after frequent 
therapies for ventric ular fibrillation storms in a Brugada syndrome case  
 
Version: 0 Date: 05 Dec 2019  
 
Reviewer: Toshimi Chiba  
 
Reviewer's report:  
 
1) General comments  
 
Dr. Zhenyi and Dr. Lishou, et al. investigated 'The propionic acid butyric acid in serum but not in 
feces are increased in p atients with diarrhea -predominant irritable bowel syndrome.'. The article 
is well presented. The reviewer has some comments.  
 
 
Comments  
 
1) The results in Table 1 would be same as Figure 2, and Table 2 would be also same as Figure 
3. The reviewer can recomme nd to use Table 1 and Table 2.  
 
2) In Results, from line 211 to 215, and from line 222 to 227, the authors described actual data in 
the text. We can understand the data in Tables. Please describe of your results more simply.  
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the stat istics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Accep table  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Refractoriness to subcutaneous implantable cardiovert er defibrillator after frequent 
therapies for ventric ular fibrillation storms in a Brugada syndrome case  
 
Version: 0 Date: 05 Dec 2019  
 
Reviewer: Toshimi Chiba  
 
Reviewer's report:  
 
1) General comments  
 
Dr. Zhenyi and Dr. Lishou, et al. investigated 'The propionic acid butyric acid in serum but not in 
feces are increased in p atients with diarrhea -predominant irritable bowel syndrome.'. The article 
is well presented. The reviewer has some comments.  
 
 
Comments  
 
1) The results in Table 1 would be same as Figure 2, and Table 2 would be also same as Figure 
3. The reviewer can recomme nd to use Table 1 and Table 2.  
 
2) In Results, from line 211 to 215, and from line 222 to 227, the authors described actual data in 
the text. We can understand the data in Tables. Please describe of your results more simply.  
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the stat istics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Accep table  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Refractoriness to subcutaneous implantable cardiovert er defibrillator after frequent 
therapies for ventric ular fibrillation storms in a Brugada syndrome case  
 
Version: 0 Date: 05 Dec 2019  
 
Reviewer: Toshimi Chiba  
 
Reviewer's report:  
 
1) General comments  
 
Dr. Zhenyi and Dr. Lishou, et al. investigated 'The propionic acid butyric acid in serum but not in 
feces are increased in p atients with diarrhea -predominant irritable bowel syndrome.'. The article 
is well presented. The reviewer has some comments.  
 
 
Comments  
 
1) The results in Table 1 would be same as Figure 2, and Table 2 would be also same as Figure 
3. The reviewer can recomme nd to use Table 1 and Table 2.  
 
2) In Results, from line 211 to 215, and from line 222 to 227, the authors described actual data in 
the text. We can understand the data in Tables. Please describe of your results more simply.  
 
 
 
Are the methods appropriate and well described?  
If not, pleas e specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately suppo rted by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an a dditional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the stat istics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Accep table  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you curr ently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any  other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named repo rt 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understan d that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant