Title: Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal
fibrostenotic strictures in patients with Crohn’s disease
Version: 4 Date: 28 Jun 2025
Reviewer's report:
Both in "Study highlights" and in the "Conclusion" authors state that "PRO-C16 serum assay
may be a potential biomarker for intestinal fibrosis ", while in the abstract they state that "PRO-
C16 may be employed as a marker of intestinal fibrosis in CD".
The detail of being a POTENTIAL biomarker is, in my opinion, very important and should figure
also in the abstract, thus avoiding the reader to misunderstand the conclusion of this  study.
Aside from this detail, I have no further comments.
Title: Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal
fibrostenotic strictures in patients with Crohn’s disease
Version: 4 Date: 28 Jun 2025
Reviewer's report:
Both in "Study highlights" and in the "Conclusion" authors state that "PRO-C16 serum assay
may be a potential biomarker for intestinal fibrosis ", while in the abstract they state that "PRO-
C16 may be employed as a marker of intestinal fibrosis in CD".
The detail of being a POTENTIAL biomarker is, in my opinion, very important and should figure
also in the abstract, thus avoiding the reader to misunderstand the conclusion of this  study.
Aside from this detail, I have no further comments.
Please review this paper.
user
Title: Serological assessment of PRO-C16 (type XVI collagen formation) reflects intestinal
fibrostenotic strictures in patients with Crohn’s disease
Version: 4 Date: 28 Jun 2025
Reviewer's report:
Both in "Study highlights" and in the "Conclusion" authors state that "PRO-C16 serum assay
may be a potential biomarker for intestinal fibrosis ", while in the abstract they state that "PRO-
C16 may be employed as a marker of intestinal fibrosis in CD".
The detail of being a POTENTIAL biomarker is, in my opinion, very important and should figure
also in the abstract, thus avoiding the reader to misunderstand the conclusion of this  study.
Aside from this detail, I have no further comments.
assistant