Title: Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for
screening colorectal cancer in the Otog Front Banner
Version: 1 Date: 17 Dec 2024
Reviewer's report:
The authors responded sincerely to the reviewers' suggestions, and the quality of the manuscripts
was improved. However, the reviewer still has several comments for the revised manuscript.
1. The authors stated that this study is a cross-sectional study using a retrospective observation
cohort. If so, the study should not involve any interventional aspect. Please clearly explain that
the fecal DNA methylation test is usually used to screen residents for CRC risk. If not, please
explain prior intervention studies conducted in the target cohort, i.e., fecal DNA methylation
studies were conducted under a specific intervention study.
2. As the authors explained in the Discussion section, multi-target stool DNA testing is much
more expensive than FIT. To overcome this shortcoming, the efficacy in terms of specificity
in reducing unnecessary following colonoscopy should be addressed. Please compare the
specificity of stool DNA testing with that of FIT, and justify the application of stool DNA testing
as a primary CRC screening method.
3. Many grammatical mistakes and typos are found. It requires English proofreading throughout
the manuscript.
Title: Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for
screening colorectal cancer in the Otog Front Banner
Version: 1 Date: 17 Dec 2024
Reviewer's report:
The authors responded sincerely to the reviewers' suggestions, and the quality of the manuscripts
was improved. However, the reviewer still has several comments for the revised manuscript.
1. The authors stated that this study is a cross-sectional study using a retrospective observation
cohort. If so, the study should not involve any interventional aspect. Please clearly explain that
the fecal DNA methylation test is usually used to screen residents for CRC risk. If not, please
explain prior intervention studies conducted in the target cohort, i.e., fecal DNA methylation
studies were conducted under a specific intervention study.
2. As the authors explained in the Discussion section, multi-target stool DNA testing is much
more expensive than FIT. To overcome this shortcoming, the efficacy in terms of specificity
in reducing unnecessary following colonoscopy should be addressed. Please compare the
specificity of stool DNA testing with that of FIT, and justify the application of stool DNA testing
as a primary CRC screening method.
3. Many grammatical mistakes and typos are found. It requires English proofreading throughout
the manuscript.
Please review this paper.
user
Title: Analysis of the effect of fecal SDC2, ADHFE1 and PPP2R5C gene methylation test for
screening colorectal cancer in the Otog Front Banner
Version: 1 Date: 17 Dec 2024
Reviewer's report:
The authors responded sincerely to the reviewers' suggestions, and the quality of the manuscripts
was improved. However, the reviewer still has several comments for the revised manuscript.
1. The authors stated that this study is a cross-sectional study using a retrospective observation
cohort. If so, the study should not involve any interventional aspect. Please clearly explain that
the fecal DNA methylation test is usually used to screen residents for CRC risk. If not, please
explain prior intervention studies conducted in the target cohort, i.e., fecal DNA methylation
studies were conducted under a specific intervention study.
2. As the authors explained in the Discussion section, multi-target stool DNA testing is much
more expensive than FIT. To overcome this shortcoming, the efficacy in terms of specificity
in reducing unnecessary following colonoscopy should be addressed. Please compare the
specificity of stool DNA testing with that of FIT, and justify the application of stool DNA testing
as a primary CRC screening method.
3. Many grammatical mistakes and typos are found. It requires English proofreading throughout
the manuscript.
assistant