Title: Hemostatic Efficacy and Safety of the Hemostatic Powder UI-EWD in Patients with
Lower Gastrointestinal Bleeding
Version: 3 Date: 28 Feb 2022
Reviewer's report:
Hemostatic Efficacy and Safety of the Hemostatic Powder UI-EWD in Patients with Lower
Gastrointestinal Bleeding
by Boram Cha and others
General comments
This interesting retrospective study presents the efficacy of the hemostatic powder UI-EWD
in the aspect of rebleeding rate within 28 days as 5.5%, which is better than other hemostatic
powders. UI-EWD was mainly used for the cases of post procedure ulcer and was applied for
the hepatic flexure. UI-EWD was also safety and there were no adverse events.
The efficacy of UI-EWD for upper gastrointestinal bleeding was already reported, especially for
tumor bleeding. Hemostatic powder with high success rate for lower gastrointestinal bleeding is
needed, especially for diverticular and tumor bleeding, which is difficult to success hemostatic
procedure.
I would recommend if for acceptance after the minor points listed below and annotated on the
manuscript are addressed.
Specific comments
# Please describe how the patients with antithrombotic therapy were treated in METHOD
section. It may affect the rebleeding rate, and so the authors should describe whether the patients
stopped antithrombotic therapy or not, and if yes, when they restarted it.
# I would recommend to mention that there were no mortality cases in both groups, if none.
Were there any death cases?
# I would recommend to demonstrate the comorbidity of eligible patients; ex. Charlson
Comorbidity index. Patient’s background may affect rebleeding.
# I would like to know how was the efficacy of UI-EWD for diverticular bleeding? If effective,
it would be extremely helpful for all endoscopists and gastroenterologists in the world. I would
recommend to mention about the efficacy for diverticular bleeding.
# Typo in the title of Table 4. “UI-EWD” is correct instead of “U-EWD”.
Title: Hemostatic Efficacy and Safety of the Hemostatic Powder UI-EWD in Patients with
Lower Gastrointestinal Bleeding
Version: 3 Date: 28 Feb 2022
Reviewer's report:
Hemostatic Efficacy and Safety of the Hemostatic Powder UI-EWD in Patients with Lower
Gastrointestinal Bleeding
by Boram Cha and others
General comments
This interesting retrospective study presents the efficacy of the hemostatic powder UI-EWD
in the aspect of rebleeding rate within 28 days as 5.5%, which is better than other hemostatic
powders. UI-EWD was mainly used for the cases of post procedure ulcer and was applied for
the hepatic flexure. UI-EWD was also safety and there were no adverse events.
The efficacy of UI-EWD for upper gastrointestinal bleeding was already reported, especially for
tumor bleeding. Hemostatic powder with high success rate for lower gastrointestinal bleeding is
needed, especially for diverticular and tumor bleeding, which is difficult to success hemostatic
procedure.
I would recommend if for acceptance after the minor points listed below and annotated on the
manuscript are addressed.
Specific comments
# Please describe how the patients with antithrombotic therapy were treated in METHOD
section. It may affect the rebleeding rate, and so the authors should describe whether the patients
stopped antithrombotic therapy or not, and if yes, when they restarted it.
# I would recommend to mention that there were no mortality cases in both groups, if none.
Were there any death cases?
# I would recommend to demonstrate the comorbidity of eligible patients; ex. Charlson
Comorbidity index. Patient’s background may affect rebleeding.
# I would like to know how was the efficacy of UI-EWD for diverticular bleeding? If effective,
it would be extremely helpful for all endoscopists and gastroenterologists in the world. I would
recommend to mention about the efficacy for diverticular bleeding.
# Typo in the title of Table 4. “UI-EWD” is correct instead of “U-EWD”.
Please review this paper.
user
Title: Hemostatic Efficacy and Safety of the Hemostatic Powder UI-EWD in Patients with
Lower Gastrointestinal Bleeding
Version: 3 Date: 28 Feb 2022
Reviewer's report:
Hemostatic Efficacy and Safety of the Hemostatic Powder UI-EWD in Patients with Lower
Gastrointestinal Bleeding
by Boram Cha and others
General comments
This interesting retrospective study presents the efficacy of the hemostatic powder UI-EWD
in the aspect of rebleeding rate within 28 days as 5.5%, which is better than other hemostatic
powders. UI-EWD was mainly used for the cases of post procedure ulcer and was applied for
the hepatic flexure. UI-EWD was also safety and there were no adverse events.
The efficacy of UI-EWD for upper gastrointestinal bleeding was already reported, especially for
tumor bleeding. Hemostatic powder with high success rate for lower gastrointestinal bleeding is
needed, especially for diverticular and tumor bleeding, which is difficult to success hemostatic
procedure.
I would recommend if for acceptance after the minor points listed below and annotated on the
manuscript are addressed.
Specific comments
# Please describe how the patients with antithrombotic therapy were treated in METHOD
section. It may affect the rebleeding rate, and so the authors should describe whether the patients
stopped antithrombotic therapy or not, and if yes, when they restarted it.
# I would recommend to mention that there were no mortality cases in both groups, if none.
Were there any death cases?
# I would recommend to demonstrate the comorbidity of eligible patients; ex. Charlson
Comorbidity index. Patient’s background may affect rebleeding.
# I would like to know how was the efficacy of UI-EWD for diverticular bleeding? If effective,
it would be extremely helpful for all endoscopists and gastroenterologists in the world. I would
recommend to mention about the efficacy for diverticular bleeding.
# Typo in the title of Table 4. “UI-EWD” is correct instead of “U-EWD”.
assistant