Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 2 Date: 28 Nov 2024
Reviewer's report:
The article "Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis" was extremely well
written. The methodology corresponds to the gold standard of systematic reviews and meta-
analysis.
This is an extremely needed article, as an expert in intestinal failure for the past 20 years, a good
quality  systematic review on quality of life for this population has been missing, as more and
more these patients survive and have to live with the burden of parenteral nutrition at home.
I defer to comment on statistics, as I'm not an expert.
The discussion was very rich and the authors have good points about the heterogeneity of this
population and the difficulties in finding good quality papers.
In conclusion, this is a very needed article, well written and  important for this field.
Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 2 Date: 28 Nov 2024
Reviewer's report:
The article "Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis" was extremely well
written. The methodology corresponds to the gold standard of systematic reviews and meta-
analysis.
This is an extremely needed article, as an expert in intestinal failure for the past 20 years, a good
quality  systematic review on quality of life for this population has been missing, as more and
more these patients survive and have to live with the burden of parenteral nutrition at home.
I defer to comment on statistics, as I'm not an expert.
The discussion was very rich and the authors have good points about the heterogeneity of this
population and the difficulties in finding good quality papers.
In conclusion, this is a very needed article, well written and  important for this field.
Please review this paper.
user
Title: Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis
Version: 2 Date: 28 Nov 2024
Reviewer's report:
The article "Health-Related Quality of Life in Pediatric Patients with Intestinal Failure without
Neurodevelopmental Delay: A Systematic Review and Meta-Analysis" was extremely well
written. The methodology corresponds to the gold standard of systematic reviews and meta-
analysis.
This is an extremely needed article, as an expert in intestinal failure for the past 20 years, a good
quality  systematic review on quality of life for this population has been missing, as more and
more these patients survive and have to live with the burden of parenteral nutrition at home.
I defer to comment on statistics, as I'm not an expert.
The discussion was very rich and the authors have good points about the heterogeneity of this
population and the difficulties in finding good quality papers.
In conclusion, this is a very needed article, well written and  important for this field.
assistant