Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 01 Aug 2024
Reviewer:  Dakui Luo
Reviewer's report:
I commend the authors for their innovative approach in identifying prognostic risk factors
associated with overall survival and cancer-specific survival in patients with synchronous
colorectal cancer. The creation of functional nomograms to predict overall and cancer-specific
survival is particularly noteworthy and represents a significant advancement in personalized
medicine for this patient population. Here are my some comments:
1. “LODDS ”did not differ in the univariate analysis (p=0.11), and why it was included in the
multivariate analysis?In addition, the caliper value of univariate analysis is not clearly set, so I
default your caliper value to p=0.05.
2.What is the form of the LODDS index in other reports, and what is its prognostic hint? In this
report, is the cutoff value set to 0.35 different enough from the other reports?
3. Among the included factors, "unknown" appeared in the results of "radiation". Does this have
an impact on the prediction results of the model?
Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 01 Aug 2024
Reviewer:  Dakui Luo
Reviewer's report:
I commend the authors for their innovative approach in identifying prognostic risk factors
associated with overall survival and cancer-specific survival in patients with synchronous
colorectal cancer. The creation of functional nomograms to predict overall and cancer-specific
survival is particularly noteworthy and represents a significant advancement in personalized
medicine for this patient population. Here are my some comments:
1. “LODDS ”did not differ in the univariate analysis (p=0.11), and why it was included in the
multivariate analysis?In addition, the caliper value of univariate analysis is not clearly set, so I
default your caliper value to p=0.05.
2.What is the form of the LODDS index in other reports, and what is its prognostic hint? In this
report, is the cutoff value set to 0.35 different enough from the other reports?
3. Among the included factors, "unknown" appeared in the results of "radiation". Does this have
an impact on the prediction results of the model?
Please review this paper.
user
Title: Developing and Validation a Prognostic Model for Predicting Prognosis Among
Synchronous Colorectal Cancers Patients Using Combined Log Odds Ratio of Positive Lymph
Nodes: a SEER Database Study
Version: 3 Date: 01 Aug 2024
Reviewer:  Dakui Luo
Reviewer's report:
I commend the authors for their innovative approach in identifying prognostic risk factors
associated with overall survival and cancer-specific survival in patients with synchronous
colorectal cancer. The creation of functional nomograms to predict overall and cancer-specific
survival is particularly noteworthy and represents a significant advancement in personalized
medicine for this patient population. Here are my some comments:
1. “LODDS ”did not differ in the univariate analysis (p=0.11), and why it was included in the
multivariate analysis?In addition, the caliper value of univariate analysis is not clearly set, so I
default your caliper value to p=0.05.
2.What is the form of the LODDS index in other reports, and what is its prognostic hint? In this
report, is the cutoff value set to 0.35 different enough from the other reports?
3. Among the included factors, "unknown" appeared in the results of "radiation". Does this have
an impact on the prediction results of the model?
assistant