Title: Correlation between PDGF-BB and M1-type macrophage in inflammatory bowel disease:
a case-control study
Version: 1 Date: 29 Oct 2024
Reviewer's report:
This scientific paper provides information regarding the correlation between PDGF-BB, M1
macrophages and newly diagnosed IBD patients, by analyzing serum and colonic expression of
cytokines well-known to be involved in the etiopathology of these diseases. It was well written
and adequately executed, with the results showing indeed a connection between the studied
factors and the diseases’ course.
Having said that, however, there is still room for improvement.
Specifically, I believe the Discussion section needs to be revised thoroughly. In its current
state, it presents in too much detail the role of the studied factors in IBD, information that yes
is important, but which should be part of the Introduction section. In my opinion, it should
focus more on all the results that derived from the present study, starting each paragraph with
statements like “in the present study … was observed”, and analyze the clinical importance and
novelty they offer to the current literature, instead of giving a brief explanation of the tested
immunological cascades.
Title: Correlation between PDGF-BB and M1-type macrophage in inflammatory bowel disease:
a case-control study
Version: 1 Date: 29 Oct 2024
Reviewer's report:
This scientific paper provides information regarding the correlation between PDGF-BB, M1
macrophages and newly diagnosed IBD patients, by analyzing serum and colonic expression of
cytokines well-known to be involved in the etiopathology of these diseases. It was well written
and adequately executed, with the results showing indeed a connection between the studied
factors and the diseases’ course.
Having said that, however, there is still room for improvement.
Specifically, I believe the Discussion section needs to be revised thoroughly. In its current
state, it presents in too much detail the role of the studied factors in IBD, information that yes
is important, but which should be part of the Introduction section. In my opinion, it should
focus more on all the results that derived from the present study, starting each paragraph with
statements like “in the present study … was observed”, and analyze the clinical importance and
novelty they offer to the current literature, instead of giving a brief explanation of the tested
immunological cascades.
Please review this paper.
user
Title: Correlation between PDGF-BB and M1-type macrophage in inflammatory bowel disease:
a case-control study
Version: 1 Date: 29 Oct 2024
Reviewer's report:
This scientific paper provides information regarding the correlation between PDGF-BB, M1
macrophages and newly diagnosed IBD patients, by analyzing serum and colonic expression of
cytokines well-known to be involved in the etiopathology of these diseases. It was well written
and adequately executed, with the results showing indeed a connection between the studied
factors and the diseases’ course.
Having said that, however, there is still room for improvement.
Specifically, I believe the Discussion section needs to be revised thoroughly. In its current
state, it presents in too much detail the role of the studied factors in IBD, information that yes
is important, but which should be part of the Introduction section. In my opinion, it should
focus more on all the results that derived from the present study, starting each paragraph with
statements like “in the present study … was observed”, and analyze the clinical importance and
novelty they offer to the current literature, instead of giving a brief explanation of the tested
immunological cascades.
assistant