Reviewer ’s report  
Title: The prevalence and phenotype in Brazilian patients with inflammatory bowel disease.  
 
Version: 1 Date: 22 Feb 2018  
 
Reviewer: Kevan Jacobson  
 
Reviewer's report:  
The authors have adequately addressed the questions that I asked.  
I have one minor comment: A question that remains to be determined is whether the prevalence 
of IBD in the state of Espirito Santo was higher than in the 2 other studies in Brazil due bette r 
data collection (as data was available for the whole state). The authors may want to indicate that 
this is one possible reason why the prevalence was higher as there may also be other reasons, 
rather than stating that this is the reason  
 
Some of the adde d text does require further editing.  
For example on page 7, line 1567 - leave out the and before 438  
Page 7, line 158 - leave out who had ie. those treated with AZA  
Page 7, line 160 Correct the spelling for patients.  
Page 7, line 161 change on to in befor e 253 and 153  
 
Page 7, discussion  
line 167 remove has and change the to a  
line 169 remove has and change the to a  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional s tatistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Needs some language corrections before being published  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing int erests' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is acce pted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons .org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
Title: The prevalence and phenotype in Brazilian patients with inflammatory bowel disease.  
 
Version: 1 Date: 22 Feb 2018  
 
Reviewer: Kevan Jacobson  
 
Reviewer's report:  
The authors have adequately addressed the questions that I asked.  
I have one minor comment: A question that remains to be determined is whether the prevalence 
of IBD in the state of Espirito Santo was higher than in the 2 other studies in Brazil due bette r 
data collection (as data was available for the whole state). The authors may want to indicate that 
this is one possible reason why the prevalence was higher as there may also be other reasons, 
rather than stating that this is the reason  
 
Some of the adde d text does require further editing.  
For example on page 7, line 1567 - leave out the and before 438  
Page 7, line 158 - leave out who had ie. those treated with AZA  
Page 7, line 160 Correct the spelling for patients.  
Page 7, line 161 change on to in befor e 253 and 153  
 
Page 7, discussion  
line 167 remove has and change the to a  
line 169 remove has and change the to a  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional s tatistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Needs some language corrections before being published  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing int erests' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is acce pted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons .org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
Title: The prevalence and phenotype in Brazilian patients with inflammatory bowel disease.  
 
Version: 1 Date: 22 Feb 2018  
 
Reviewer: Kevan Jacobson  
 
Reviewer's report:  
The authors have adequately addressed the questions that I asked.  
I have one minor comment: A question that remains to be determined is whether the prevalence 
of IBD in the state of Espirito Santo was higher than in the 2 other studies in Brazil due bette r 
data collection (as data was available for the whole state). The authors may want to indicate that 
this is one possible reason why the prevalence was higher as there may also be other reasons, 
rather than stating that this is the reason  
 
Some of the adde d text does require further editing.  
For example on page 7, line 1567 - leave out the and before 438  
Page 7, line 158 - leave out who had ie. those treated with AZA  
Page 7, line 160 Correct the spelling for patients.  
Page 7, line 161 change on to in befor e 253 and 153  
 
Page 7, discussion  
line 167 remove has and change the to a  
line 169 remove has and change the to a  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
Yes 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
Yes 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
Yes 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional s tatistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
I am able to assess the statistics  
Quality of written English  
Please indicate the quality of language in the manuscript:  
Needs some language corrections before being published  
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publi cation of this 
manuscript, either now or in the future?  
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
6. Do you have any non -financial competing interests in relation to this paper?  
If you can answer no to all of the above, write 'I declare that I have no competing int erests' 
below. If your reply is yes to any, please give details below.  
 
I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is acce pted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons .org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant