Title: The relationship between the use of metformin and the risk of pancreatic cancer in patients
with diabetes: A systematic review and meta-analysis
Version: 2 Date: 17 Dec 2022
Reviewer's report:
Very interesting study. My main concern is on the lack of a time-dependent analysis. The crude
OR doesn't take into account the timespan of the effect of metformin on cancer incidence......one
year of metformin therapy is not the same of 10 year of metformin therapy....how can the authors
assess this issue?
Also, i recommend to cite the effect of these drugs (metformin, statins, and other similar drugs)
on the incidence of other cancers (cite PMID: 32260179 )
Also, the authors should cite how the use of these drugs change the epidemiologic scenario of
abdominal cancers (cite PMID: 33219585)
Finally the authors should cite the influence of diabetes on the incidence of several abdominal
cancers (cite PMID: 23845075 )
Title: The relationship between the use of metformin and the risk of pancreatic cancer in patients
with diabetes: A systematic review and meta-analysis
Version: 2 Date: 17 Dec 2022
Reviewer's report:
Very interesting study. My main concern is on the lack of a time-dependent analysis. The crude
OR doesn't take into account the timespan of the effect of metformin on cancer incidence......one
year of metformin therapy is not the same of 10 year of metformin therapy....how can the authors
assess this issue?
Also, i recommend to cite the effect of these drugs (metformin, statins, and other similar drugs)
on the incidence of other cancers (cite PMID: 32260179 )
Also, the authors should cite how the use of these drugs change the epidemiologic scenario of
abdominal cancers (cite PMID: 33219585)
Finally the authors should cite the influence of diabetes on the incidence of several abdominal
cancers (cite PMID: 23845075 )
Please review this paper.
user
Title: The relationship between the use of metformin and the risk of pancreatic cancer in patients
with diabetes: A systematic review and meta-analysis
Version: 2 Date: 17 Dec 2022
Reviewer's report:
Very interesting study. My main concern is on the lack of a time-dependent analysis. The crude
OR doesn't take into account the timespan of the effect of metformin on cancer incidence......one
year of metformin therapy is not the same of 10 year of metformin therapy....how can the authors
assess this issue?
Also, i recommend to cite the effect of these drugs (metformin, statins, and other similar drugs)
on the incidence of other cancers (cite PMID: 32260179 )
Also, the authors should cite how the use of these drugs change the epidemiologic scenario of
abdominal cancers (cite PMID: 33219585)
Finally the authors should cite the influence of diabetes on the incidence of several abdominal
cancers (cite PMID: 23845075 )
assistant