Title: The association between hemoglobin level and sarcopenia in Chinese patients with
Crohn's disease
Version: 2 Date: 15 Jan 2024
Reviewer's report:
The authors have addressed some of the raised points, but several concerns remain. A plausible
explanation for the relationship between anemia and sarcopenia may be linked to disease
activity. If data on disease activity are lacking, explaining the level of anemia and ensuring the
association with CD becomes challenging.
The authors assert that malnutrition causes anemia and sarcopenia. The connection between
malnutrition and sarcopenia has already been demonstrated [doi: 10.3390/nu14173460].
However, in the current study, the number of patients suffering from malnutrition is unknown.
Please include this data
Also, consider whether other comorbidities or other conditions (such as age, comorbidity, and
sedentary activity) could cause anemia, and provide this information.
Given recent diagnoses, understanding the impact of CD inflammation on sarcopenia
development is questionable. Please provide a comment about this.
As previously argued, granulomas cannot be detected via endoscopy; this is a histological
feature. Please correct and explain how the authors identify the presence of granulomas.
The authors state, "Sarcopenia evaluated by CTE or MRE did not cause additional cost or
ionizing radiation." Remove CTE from this sentence, as it is associated with ionizing radiation.
There's a lack of other Montreal parameters. Please add L2, L3, and B2, B3 percentages.
Change the Montreal classification in Table 1 accordingly.
Regrettably, the manuscript, in its current form, still suffers from logically cumbersome
passages. The discussion section, in particular, contains redundant sentences. For instance, the
statement "if anemia or low hemoglobin level is associated with sarcopenia, the sarcopenia may
be improved by the intervention on anemia. Consequently, clinical outcomes may be improved"
is repeated twice. Please revise and tone down this sentence, as it lacks evidence support.
Title: The association between hemoglobin level and sarcopenia in Chinese patients with
Crohn's disease
Version: 2 Date: 15 Jan 2024
Reviewer's report:
The authors have addressed some of the raised points, but several concerns remain. A plausible
explanation for the relationship between anemia and sarcopenia may be linked to disease
activity. If data on disease activity are lacking, explaining the level of anemia and ensuring the
association with CD becomes challenging.
The authors assert that malnutrition causes anemia and sarcopenia. The connection between
malnutrition and sarcopenia has already been demonstrated [doi: 10.3390/nu14173460].
However, in the current study, the number of patients suffering from malnutrition is unknown.
Please include this data
Also, consider whether other comorbidities or other conditions (such as age, comorbidity, and
sedentary activity) could cause anemia, and provide this information.
Given recent diagnoses, understanding the impact of CD inflammation on sarcopenia
development is questionable. Please provide a comment about this.
As previously argued, granulomas cannot be detected via endoscopy; this is a histological
feature. Please correct and explain how the authors identify the presence of granulomas.
The authors state, "Sarcopenia evaluated by CTE or MRE did not cause additional cost or
ionizing radiation." Remove CTE from this sentence, as it is associated with ionizing radiation.
There's a lack of other Montreal parameters. Please add L2, L3, and B2, B3 percentages.
Change the Montreal classification in Table 1 accordingly.
Regrettably, the manuscript, in its current form, still suffers from logically cumbersome
passages. The discussion section, in particular, contains redundant sentences. For instance, the
statement "if anemia or low hemoglobin level is associated with sarcopenia, the sarcopenia may
be improved by the intervention on anemia. Consequently, clinical outcomes may be improved"
is repeated twice. Please revise and tone down this sentence, as it lacks evidence support.
Please review this paper.
user
Title: The association between hemoglobin level and sarcopenia in Chinese patients with
Crohn's disease
Version: 2 Date: 15 Jan 2024
Reviewer's report:
The authors have addressed some of the raised points, but several concerns remain. A plausible
explanation for the relationship between anemia and sarcopenia may be linked to disease
activity. If data on disease activity are lacking, explaining the level of anemia and ensuring the
association with CD becomes challenging.
The authors assert that malnutrition causes anemia and sarcopenia. The connection between
malnutrition and sarcopenia has already been demonstrated [doi: 10.3390/nu14173460].
However, in the current study, the number of patients suffering from malnutrition is unknown.
Please include this data
Also, consider whether other comorbidities or other conditions (such as age, comorbidity, and
sedentary activity) could cause anemia, and provide this information.
Given recent diagnoses, understanding the impact of CD inflammation on sarcopenia
development is questionable. Please provide a comment about this.
As previously argued, granulomas cannot be detected via endoscopy; this is a histological
feature. Please correct and explain how the authors identify the presence of granulomas.
The authors state, "Sarcopenia evaluated by CTE or MRE did not cause additional cost or
ionizing radiation." Remove CTE from this sentence, as it is associated with ionizing radiation.
There's a lack of other Montreal parameters. Please add L2, L3, and B2, B3 percentages.
Change the Montreal classification in Table 1 accordingly.
Regrettably, the manuscript, in its current form, still suffers from logically cumbersome
passages. The discussion section, in particular, contains redundant sentences. For instance, the
statement "if anemia or low hemoglobin level is associated with sarcopenia, the sarcopenia may
be improved by the intervention on anemia. Consequently, clinical outcomes may be improved"
is repeated twice. Please revise and tone down this sentence, as it lacks evidence support.
assistant