Reviewer's report
Title:Treatment with Pirfenidone for two years decreases fibrosis, cytokine levels
and enhances CB2 expression in patients with chronic hepatitis C: open-label
clinical trial
Version:5Date:26 June 2014
Reviewer: luigi adinolfi
Reviewer's report:
The paper is substantial improved, however there are some points that must be
modified/commented.
1. the reference, Zampino et al must be numbered in progression, thus the
reference is not [42] but [15]. All the others reference must be changed
accordingly.
2.Since the variations on CB1 and CB2 are not significant or slight significant, I
strongly suggest to cite the paper of Coppola et al. suggesting that the diversity
could be due to different polymorphisms to be evaluated in future studies.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Treatment with Pirfenidone for two years decreases fibrosis, cytokine levels
and enhances CB2 expression in patients with chronic hepatitis C: open-label
clinical trial
Version:5Date:26 June 2014
Reviewer: luigi adinolfi
Reviewer's report:
The paper is substantial improved, however there are some points that must be
modified/commented.
1. the reference, Zampino et al must be numbered in progression, thus the
reference is not [42] but [15]. All the others reference must be changed
accordingly.
2.Since the variations on CB1 and CB2 are not significant or slight significant, I
strongly suggest to cite the paper of Coppola et al. suggesting that the diversity
could be due to different polymorphisms to be evaluated in future studies.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Treatment with Pirfenidone for two years decreases fibrosis, cytokine levels
and enhances CB2 expression in patients with chronic hepatitis C: open-label
clinical trial
Version:5Date:26 June 2014
Reviewer: luigi adinolfi
Reviewer's report:
The paper is substantial improved, however there are some points that must be
modified/commented.
1. the reference, Zampino et al must be numbered in progression, thus the
reference is not [42] but [15]. All the others reference must be changed
accordingly.
2.Since the variations on CB1 and CB2 are not significant or slight significant, I
strongly suggest to cite the paper of Coppola et al. suggesting that the diversity
could be due to different polymorphisms to be evaluated in future studies.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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