Title: Network meta-analysis on efficacy and safety of different biologics for ulcerative colitis
Version: 3 Date: 18 Jun 2023
Reviewer's report:
Gu et al present their study titled "Network meta-analysis on efficacy and safety of different
biologics for ulcerative colitis". The study is overall well written  however has a few major
limitations
1. The authors have combined outcomes for mild, moderate and severe UC which is problematic
in terms of clinical applicability
2. The authors do not reports outcomes for induction vs maintainence phase of therapy outcomes
3. The literature search was carried out in 9/2022, therefore several new studies/abstracts are
not included
4. Similar studies have been published on this topic -
https://pubmed.ncbi.nlm.nih.gov/36998249/
https://pubmed.ncbi.nlm.nih.gov/34856198/
Title: Network meta-analysis on efficacy and safety of different biologics for ulcerative colitis
Version: 3 Date: 18 Jun 2023
Reviewer's report:
Gu et al present their study titled "Network meta-analysis on efficacy and safety of different
biologics for ulcerative colitis". The study is overall well written  however has a few major
limitations
1. The authors have combined outcomes for mild, moderate and severe UC which is problematic
in terms of clinical applicability
2. The authors do not reports outcomes for induction vs maintainence phase of therapy outcomes
3. The literature search was carried out in 9/2022, therefore several new studies/abstracts are
not included
4. Similar studies have been published on this topic -
https://pubmed.ncbi.nlm.nih.gov/36998249/
https://pubmed.ncbi.nlm.nih.gov/34856198/
Please review this paper.
user
Title: Network meta-analysis on efficacy and safety of different biologics for ulcerative colitis
Version: 3 Date: 18 Jun 2023
Reviewer's report:
Gu et al present their study titled "Network meta-analysis on efficacy and safety of different
biologics for ulcerative colitis". The study is overall well written  however has a few major
limitations
1. The authors have combined outcomes for mild, moderate and severe UC which is problematic
in terms of clinical applicability
2. The authors do not reports outcomes for induction vs maintainence phase of therapy outcomes
3. The literature search was carried out in 9/2022, therefore several new studies/abstracts are
not included
4. Similar studies have been published on this topic -
https://pubmed.ncbi.nlm.nih.gov/36998249/
https://pubmed.ncbi.nlm.nih.gov/34856198/
assistant