Title: Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative
gastric cancer patients: the FIESTA study
Version: 2 Date: 24 Jul 2022
Reviewer:  Tsutomu Namikawa
Reviewer's report:
I read the manuscript “Prognostic value of long-term antidiabetic and antihypertensive therapy in
postoperative gastric cancer patients: the FIESTA study". The authors investigated the efficacy
of the long-term antihypertensive and antidiabetic therapy for the patients who underwent
gastrectomy for gastric cancer in authors’ institute. This paper had a valuable information to
treat gastric cancer; however, there were several unclear points to be revised. My comments are
as follow.
1. The authors described that patients with diabetes mellitus and hypertension had remarkably
poorer survival duration than non-hypertension and non-diabetic patients. However, Figure
1 showed that patients with hypertension had better survival duration than non-hypertension
patients. Authors should confirm this result.
2. Generally, many factors are involved in survival of patients with cancer. In this study, the
untreated diabetes mellitus group had more stage IV and underwent chemotherapy patients than
the other two group. Have you tried these results in a multivariate analysis?
3. Abbreviations should be defined at the first appearance (i.e., AMPK, PD-L1). The authors
should prepare the manuscript with close attention.
Title: Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative
gastric cancer patients: the FIESTA study
Version: 2 Date: 24 Jul 2022
Reviewer:  Tsutomu Namikawa
Reviewer's report:
I read the manuscript “Prognostic value of long-term antidiabetic and antihypertensive therapy in
postoperative gastric cancer patients: the FIESTA study". The authors investigated the efficacy
of the long-term antihypertensive and antidiabetic therapy for the patients who underwent
gastrectomy for gastric cancer in authors’ institute. This paper had a valuable information to
treat gastric cancer; however, there were several unclear points to be revised. My comments are
as follow.
1. The authors described that patients with diabetes mellitus and hypertension had remarkably
poorer survival duration than non-hypertension and non-diabetic patients. However, Figure
1 showed that patients with hypertension had better survival duration than non-hypertension
patients. Authors should confirm this result.
2. Generally, many factors are involved in survival of patients with cancer. In this study, the
untreated diabetes mellitus group had more stage IV and underwent chemotherapy patients than
the other two group. Have you tried these results in a multivariate analysis?
3. Abbreviations should be defined at the first appearance (i.e., AMPK, PD-L1). The authors
should prepare the manuscript with close attention.
Please review this paper.
user
Title: Prognostic value of long-term antidiabetic and antihypertensive therapy in postoperative
gastric cancer patients: the FIESTA study
Version: 2 Date: 24 Jul 2022
Reviewer:  Tsutomu Namikawa
Reviewer's report:
I read the manuscript “Prognostic value of long-term antidiabetic and antihypertensive therapy in
postoperative gastric cancer patients: the FIESTA study". The authors investigated the efficacy
of the long-term antihypertensive and antidiabetic therapy for the patients who underwent
gastrectomy for gastric cancer in authors’ institute. This paper had a valuable information to
treat gastric cancer; however, there were several unclear points to be revised. My comments are
as follow.
1. The authors described that patients with diabetes mellitus and hypertension had remarkably
poorer survival duration than non-hypertension and non-diabetic patients. However, Figure
1 showed that patients with hypertension had better survival duration than non-hypertension
patients. Authors should confirm this result.
2. Generally, many factors are involved in survival of patients with cancer. In this study, the
untreated diabetes mellitus group had more stage IV and underwent chemotherapy patients than
the other two group. Have you tried these results in a multivariate analysis?
3. Abbreviations should be defined at the first appearance (i.e., AMPK, PD-L1). The authors
should prepare the manuscript with close attention.
assistant