Title: Proton beam therapy for hepatocellular carcinoma with bile duct invasion
Version: 1 Date: 25 May 2023
Reviewer's report:
The aim of this retrospective study was to clarify the efficacy and safety of proton beam
therapy for hepatocellular carcinoma with bile duct invasion. Fifteen patients treated with proton
beam therapy were observed to have overall survival, local recurrence, progression survival
and adverse events. This study concluded that proton beam therapy was feasible with tolerable
toxicities for the treatment of hepatocellular carcinoma with bile duct invasion.
Hepatocellular carcinoma with bile duct invasion is rare, and resection has traditionally been the
primary treatment. The authors studied the efficacy and safety of treatment with the proton beam.
Major problem:
The DISCUSSION is redundant and lacks logic. Therefore, it is difficult to understand.
This study investigated the usefulness of proton beam therapy for hepatocellular carcinoma with
bile duct invasion. It would be easier to understand if we first list the problems from effectiveness
and safety in conventional treatment methods and then discuss conventional therapy and proton
beam therapy with comparison.
Miner problems:
1. Two out of 15 cases were described as recurrence-free. These recurrence-free patients had no
intrahepatic, distant, or local recurrences. However, the PFS at 3 years is 0%. Did both cases
die within 3 years without recurrence?
2. A statement is needed in the methods section regarding central vs. peripheral.
3. There are grammatical problems and spelling errors. Please proofread English by native.
Title: Proton beam therapy for hepatocellular carcinoma with bile duct invasion
Version: 1 Date: 25 May 2023
Reviewer's report:
The aim of this retrospective study was to clarify the efficacy and safety of proton beam
therapy for hepatocellular carcinoma with bile duct invasion. Fifteen patients treated with proton
beam therapy were observed to have overall survival, local recurrence, progression survival
and adverse events. This study concluded that proton beam therapy was feasible with tolerable
toxicities for the treatment of hepatocellular carcinoma with bile duct invasion.
Hepatocellular carcinoma with bile duct invasion is rare, and resection has traditionally been the
primary treatment. The authors studied the efficacy and safety of treatment with the proton beam.
Major problem:
The DISCUSSION is redundant and lacks logic. Therefore, it is difficult to understand.
This study investigated the usefulness of proton beam therapy for hepatocellular carcinoma with
bile duct invasion. It would be easier to understand if we first list the problems from effectiveness
and safety in conventional treatment methods and then discuss conventional therapy and proton
beam therapy with comparison.
Miner problems:
1. Two out of 15 cases were described as recurrence-free. These recurrence-free patients had no
intrahepatic, distant, or local recurrences. However, the PFS at 3 years is 0%. Did both cases
die within 3 years without recurrence?
2. A statement is needed in the methods section regarding central vs. peripheral.
3. There are grammatical problems and spelling errors. Please proofread English by native.
Please review this paper.
user
Title: Proton beam therapy for hepatocellular carcinoma with bile duct invasion
Version: 1 Date: 25 May 2023
Reviewer's report:
The aim of this retrospective study was to clarify the efficacy and safety of proton beam
therapy for hepatocellular carcinoma with bile duct invasion. Fifteen patients treated with proton
beam therapy were observed to have overall survival, local recurrence, progression survival
and adverse events. This study concluded that proton beam therapy was feasible with tolerable
toxicities for the treatment of hepatocellular carcinoma with bile duct invasion.
Hepatocellular carcinoma with bile duct invasion is rare, and resection has traditionally been the
primary treatment. The authors studied the efficacy and safety of treatment with the proton beam.
Major problem:
The DISCUSSION is redundant and lacks logic. Therefore, it is difficult to understand.
This study investigated the usefulness of proton beam therapy for hepatocellular carcinoma with
bile duct invasion. It would be easier to understand if we first list the problems from effectiveness
and safety in conventional treatment methods and then discuss conventional therapy and proton
beam therapy with comparison.
Miner problems:
1. Two out of 15 cases were described as recurrence-free. These recurrence-free patients had no
intrahepatic, distant, or local recurrences. However, the PFS at 3 years is 0%. Did both cases
die within 3 years without recurrence?
2. A statement is needed in the methods section regarding central vs. peripheral.
3. There are grammatical problems and spelling errors. Please proofread English by native.
assistant