Reviewer's report
Title:Short term micronutrient-antioxidant supplementation has no impact on
gastric atrophy in Zambian adults: retrospective analysis of a randomised
controlled trial
Version:2Date:18 February 2014
Reviewer: Yutaka Yamaji
Reviewer's report:
This study is a sub-analysis of a previous randomized controlled trial and aimed
to investigate the effect of micronutrient-antioxidant supplementation on
prevention of gastric atrophy.
1. The primary outcome of the original randomized trial should be presented.
2. H. pylori is a major factor for gastric atrophy and gastric cancer development.
The eradication of H. pylori is the most promising strategy to prevent them. The
eradication of H. pylori before or during the study should be presented. The
strategy of the micronutrient-antioxidant supplementation should also be
discussed in comparison with H. pylori eradication strategy.
3. The low prevalence of gastric atrophy irrespective of the high prevalence of H.
pylori infection in this study should be discussed. Young age, low prevalence of
Cag-A positive species, or recent eradication might be involved.
4. Please show each pepsinogen I and II level and I/II ratio, before and after the
treatment, if the data are available. The difference in the changes of pepsinogen
levels might be found between treatment and placebo groups. In addition, these
data among younger generation are scarce and interesting.
5. Pepsinogen level is known to be affected by acid suppressors or renal failure,
which should be presented.
6. The odds ratio of “0.28” for age over 40 years in Table 4 seems to be
miswritten. Please check.
7. As the author discussed, the study period seems to be too short to investigate
the effect on gastric atrophy. The last conclusion by the authors could be
modified.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Short term micronutrient-antioxidant supplementation has no impact on
gastric atrophy in Zambian adults: retrospective analysis of a randomised
controlled trial
Version:2Date:18 February 2014
Reviewer: Yutaka Yamaji
Reviewer's report:
This study is a sub-analysis of a previous randomized controlled trial and aimed
to investigate the effect of micronutrient-antioxidant supplementation on
prevention of gastric atrophy.
1. The primary outcome of the original randomized trial should be presented.
2. H. pylori is a major factor for gastric atrophy and gastric cancer development.
The eradication of H. pylori is the most promising strategy to prevent them. The
eradication of H. pylori before or during the study should be presented. The
strategy of the micronutrient-antioxidant supplementation should also be
discussed in comparison with H. pylori eradication strategy.
3. The low prevalence of gastric atrophy irrespective of the high prevalence of H.
pylori infection in this study should be discussed. Young age, low prevalence of
Cag-A positive species, or recent eradication might be involved.
4. Please show each pepsinogen I and II level and I/II ratio, before and after the
treatment, if the data are available. The difference in the changes of pepsinogen
levels might be found between treatment and placebo groups. In addition, these
data among younger generation are scarce and interesting.
5. Pepsinogen level is known to be affected by acid suppressors or renal failure,
which should be presented.
6. The odds ratio of “0.28” for age over 40 years in Table 4 seems to be
miswritten. Please check.
7. As the author discussed, the study period seems to be too short to investigate
the effect on gastric atrophy. The last conclusion by the authors could be
modified.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Short term micronutrient-antioxidant supplementation has no impact on
gastric atrophy in Zambian adults: retrospective analysis of a randomised
controlled trial
Version:2Date:18 February 2014
Reviewer: Yutaka Yamaji
Reviewer's report:
This study is a sub-analysis of a previous randomized controlled trial and aimed
to investigate the effect of micronutrient-antioxidant supplementation on
prevention of gastric atrophy.
1. The primary outcome of the original randomized trial should be presented.
2. H. pylori is a major factor for gastric atrophy and gastric cancer development.
The eradication of H. pylori is the most promising strategy to prevent them. The
eradication of H. pylori before or during the study should be presented. The
strategy of the micronutrient-antioxidant supplementation should also be
discussed in comparison with H. pylori eradication strategy.
3. The low prevalence of gastric atrophy irrespective of the high prevalence of H.
pylori infection in this study should be discussed. Young age, low prevalence of
Cag-A positive species, or recent eradication might be involved.
4. Please show each pepsinogen I and II level and I/II ratio, before and after the
treatment, if the data are available. The difference in the changes of pepsinogen
levels might be found between treatment and placebo groups. In addition, these
data among younger generation are scarce and interesting.
5. Pepsinogen level is known to be affected by acid suppressors or renal failure,
which should be presented.
6. The odds ratio of “0.28” for age over 40 years in Table 4 seems to be
miswritten. Please check.
7. As the author discussed, the study period seems to be too short to investigate
the effect on gastric atrophy. The last conclusion by the authors could be
modified.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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