Title: The Role of Exercise-based Prehabilitation in Enhancing Surgical Outcomes for Patients
with Digestive System Cancers: A Meta-Analysis
Version: 1 Date: 15 Nov 2024
Reviewer's report:
Prehabilitation is a major item in gastrointestinal surgery. This meta-analysis is based on 13
RCT, especially analysing the effects of rehabilitation on postoperative complications, LOS and
pre surgical optimaziation of patients.
Although the manuscript is well written, there are some  shortcomings
Surgical interventions are not really comparable. Although the majority of RCT reports
colorectal surgery, there are also reports of pancreatectomy, esophagogastric surgery and
heterogenous GI tumors. This heterogeneity of patients included is not addressed, although there
is a clear imbalance;ance in the risk of postoperative complications.
Also a striking item is, that rehabilitation decreases postoperative complications over all, but
not severe complications (DC 3 or higher). Data on overall and major complications should be
presented more detailed. It has to be addressed in the discussion and conclusion, that no effect
was seen in major complications
other items:
line 195: Six studies are mentioned, but only 5 cited
line 209: it should be Egger
Title: The Role of Exercise-based Prehabilitation in Enhancing Surgical Outcomes for Patients
with Digestive System Cancers: A Meta-Analysis
Version: 1 Date: 15 Nov 2024
Reviewer's report:
Prehabilitation is a major item in gastrointestinal surgery. This meta-analysis is based on 13
RCT, especially analysing the effects of rehabilitation on postoperative complications, LOS and
pre surgical optimaziation of patients.
Although the manuscript is well written, there are some  shortcomings
Surgical interventions are not really comparable. Although the majority of RCT reports
colorectal surgery, there are also reports of pancreatectomy, esophagogastric surgery and
heterogenous GI tumors. This heterogeneity of patients included is not addressed, although there
is a clear imbalance;ance in the risk of postoperative complications.
Also a striking item is, that rehabilitation decreases postoperative complications over all, but
not severe complications (DC 3 or higher). Data on overall and major complications should be
presented more detailed. It has to be addressed in the discussion and conclusion, that no effect
was seen in major complications
other items:
line 195: Six studies are mentioned, but only 5 cited
line 209: it should be Egger
Please review this paper.
user
Title: The Role of Exercise-based Prehabilitation in Enhancing Surgical Outcomes for Patients
with Digestive System Cancers: A Meta-Analysis
Version: 1 Date: 15 Nov 2024
Reviewer's report:
Prehabilitation is a major item in gastrointestinal surgery. This meta-analysis is based on 13
RCT, especially analysing the effects of rehabilitation on postoperative complications, LOS and
pre surgical optimaziation of patients.
Although the manuscript is well written, there are some  shortcomings
Surgical interventions are not really comparable. Although the majority of RCT reports
colorectal surgery, there are also reports of pancreatectomy, esophagogastric surgery and
heterogenous GI tumors. This heterogeneity of patients included is not addressed, although there
is a clear imbalance;ance in the risk of postoperative complications.
Also a striking item is, that rehabilitation decreases postoperative complications over all, but
not severe complications (DC 3 or higher). Data on overall and major complications should be
presented more detailed. It has to be addressed in the discussion and conclusion, that no effect
was seen in major complications
other items:
line 195: Six studies are mentioned, but only 5 cited
line 209: it should be Egger
assistant