Title: Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal
hemodynamics and liver function
Version: 2 Date: 02 May 2022
Reviewer's report:
This manuscript evaluated portal hemodynamics and liver function in patients who was treated
with endoscopic injection sclerotherapy. This research has great clinical significance, and can
further guider the selection of clinical treatment options. The use of Xe-CT to research portal
hemodynamics is novel and interesting. However, there are some questions after reading this
article.
1.Authors mentioned this as a prospective study, but this research is more like a retrospective
study based on the content.
2.Authors mentioned “all patients with gastrorenal shunts were performed balloon occluded
retrograde transvenous obliteration before EIS”, but the effect of BRTO on portal blood flow
was not took into account. This should be discussed.
3.Generally speaking, portal blood flow should be increased after EIS. Try to discuss the possible
reasons that portal blood flow in some patients was decreased after EIS.
4.Generally, liver function is described in form of score-system (eg. Child-Pugh, MELD). Try
to list the changes of these scores in the results.
5.More patiens need to be included to validate the results.
Title: Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal
hemodynamics and liver function
Version: 2 Date: 02 May 2022
Reviewer's report:
This manuscript evaluated portal hemodynamics and liver function in patients who was treated
with endoscopic injection sclerotherapy. This research has great clinical significance, and can
further guider the selection of clinical treatment options. The use of Xe-CT to research portal
hemodynamics is novel and interesting. However, there are some questions after reading this
article.
1.Authors mentioned this as a prospective study, but this research is more like a retrospective
study based on the content.
2.Authors mentioned “all patients with gastrorenal shunts were performed balloon occluded
retrograde transvenous obliteration before EIS”, but the effect of BRTO on portal blood flow
was not took into account. This should be discussed.
3.Generally speaking, portal blood flow should be increased after EIS. Try to discuss the possible
reasons that portal blood flow in some patients was decreased after EIS.
4.Generally, liver function is described in form of score-system (eg. Child-Pugh, MELD). Try
to list the changes of these scores in the results.
5.More patiens need to be included to validate the results.
Please review this paper.
user
Title: Effects of endoscopic injection sclerotherapy for esophagogastric varices on portal
hemodynamics and liver function
Version: 2 Date: 02 May 2022
Reviewer's report:
This manuscript evaluated portal hemodynamics and liver function in patients who was treated
with endoscopic injection sclerotherapy. This research has great clinical significance, and can
further guider the selection of clinical treatment options. The use of Xe-CT to research portal
hemodynamics is novel and interesting. However, there are some questions after reading this
article.
1.Authors mentioned this as a prospective study, but this research is more like a retrospective
study based on the content.
2.Authors mentioned “all patients with gastrorenal shunts were performed balloon occluded
retrograde transvenous obliteration before EIS”, but the effect of BRTO on portal blood flow
was not took into account. This should be discussed.
3.Generally speaking, portal blood flow should be increased after EIS. Try to discuss the possible
reasons that portal blood flow in some patients was decreased after EIS.
4.Generally, liver function is described in form of score-system (eg. Child-Pugh, MELD). Try
to list the changes of these scores in the results.
5.More patiens need to be included to validate the results.
assistant