Title: Effectiveness of antiviral treatment in HBeAg-negative chronic hepatitis B patients with
normal or mildly elevated alanine aminotransferase: A retrospective study
Version: 1 Date: 09 Jul 2022
Reviewer:  Tawesak Tanwandee
Reviewer's report:
I have read the manuscript “Effectiveness of antiviral treatment in HBeAg-negative patients
with normal or mildly elevated alanine aminotransferase: a retrospective study” with interest.
There are some questions and comments
1. Since it was retrospective collection and use data from 2 hospitals, how can one control
whether the Fibroscan was done as mentioned? I assumed that all of these data were from patient
charts.
2. What are the criteria for normal and mildly elevated ALT
3. What was the NA treatment? Since baseline HBV DNA was low but response rate was slow.
4. Since Baseline LSM was high, how many patients had significant fibrosis
5. How about improving ALT after receiving treatment?
Title: Effectiveness of antiviral treatment in HBeAg-negative chronic hepatitis B patients with
normal or mildly elevated alanine aminotransferase: A retrospective study
Version: 1 Date: 09 Jul 2022
Reviewer:  Tawesak Tanwandee
Reviewer's report:
I have read the manuscript “Effectiveness of antiviral treatment in HBeAg-negative patients
with normal or mildly elevated alanine aminotransferase: a retrospective study” with interest.
There are some questions and comments
1. Since it was retrospective collection and use data from 2 hospitals, how can one control
whether the Fibroscan was done as mentioned? I assumed that all of these data were from patient
charts.
2. What are the criteria for normal and mildly elevated ALT
3. What was the NA treatment? Since baseline HBV DNA was low but response rate was slow.
4. Since Baseline LSM was high, how many patients had significant fibrosis
5. How about improving ALT after receiving treatment?
Please review this paper.
user
Title: Effectiveness of antiviral treatment in HBeAg-negative chronic hepatitis B patients with
normal or mildly elevated alanine aminotransferase: A retrospective study
Version: 1 Date: 09 Jul 2022
Reviewer:  Tawesak Tanwandee
Reviewer's report:
I have read the manuscript “Effectiveness of antiviral treatment in HBeAg-negative patients
with normal or mildly elevated alanine aminotransferase: a retrospective study” with interest.
There are some questions and comments
1. Since it was retrospective collection and use data from 2 hospitals, how can one control
whether the Fibroscan was done as mentioned? I assumed that all of these data were from patient
charts.
2. What are the criteria for normal and mildly elevated ALT
3. What was the NA treatment? Since baseline HBV DNA was low but response rate was slow.
4. Since Baseline LSM was high, how many patients had significant fibrosis
5. How about improving ALT after receiving treatment?
assistant