Reviewer's report
Title:Nutritional Status of Adolescents with Crohn's Disease: A Prospective
Cross-sectional Study
Version:2Date:4 July 2015
Reviewer: Annalisa Schiepatti
Reviewer's report:
Major Compulsory Revisions
1. The problem of undernutrition/malnutrition in adolescents affected by CD is an
important one and it is clearly explained in the text. The aim of the study to
provide a snapshot of the nutritional status of CD adolescents in Brazil must be
clearly stated also in the title, abstract and discussion (not only in the last few
lines of the "Background").
2. On the basis of the present study, Brazilian adolescents affected by CD are at
nutritional risk. However, in the biochemical assessment of the nutritional status,
some important parameters are lacking: haemoglobin, prealbumin, cholesterol,
triglycerides. All these parameters are quite easy to be obtained and some of
them are of outmost importance in the baseline clinical evaluation of CD patients
and may influence clinical decisions. In particular hemoglobin because CD
patients very often suffer from anemia. Moreover, it would have been very
interesting to see hemoglobin values, in light of the iron deficiency that resulted
higher in inactive CD than active CD. Secondly, prealbumin, given its shorter
halflife than that of albumin, is a very good parameter to evaluate nutritional
status.
3. Discussion is quite rough. It is absolutely necessary to have a more detailed
and critical approach to results (for example, the problem of iron deficiency is
discussed, whereas albumin deficiency is not). Then, the limitations of the study,
if any, must be clearly stated (that, actually, are completely lacking). Secondly,
any information about the duration of the study must be given in the "Methods"
section and not only rapidly mentioned in the "Discussion"(see the first paragraph
of "Discussion").
4. Pay attention to the discrepancy between saying that a result is not statistically
significant and the p value written in brackets (see the first line on page 11 in the
manuscript). Please, correct it.
MINOR ESSENTIAL REVISIONS
1. Please correct "The controls were selected from among individuals" by
deleting "from"(at the beginning of the Methods section)
DISCRETIONARY REVISIONS
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Nutritional Status of Adolescents with Crohn's Disease: A Prospective
Cross-sectional Study
Version:2Date:4 July 2015
Reviewer: Annalisa Schiepatti
Reviewer's report:
Major Compulsory Revisions
1. The problem of undernutrition/malnutrition in adolescents affected by CD is an
important one and it is clearly explained in the text. The aim of the study to
provide a snapshot of the nutritional status of CD adolescents in Brazil must be
clearly stated also in the title, abstract and discussion (not only in the last few
lines of the "Background").
2. On the basis of the present study, Brazilian adolescents affected by CD are at
nutritional risk. However, in the biochemical assessment of the nutritional status,
some important parameters are lacking: haemoglobin, prealbumin, cholesterol,
triglycerides. All these parameters are quite easy to be obtained and some of
them are of outmost importance in the baseline clinical evaluation of CD patients
and may influence clinical decisions. In particular hemoglobin because CD
patients very often suffer from anemia. Moreover, it would have been very
interesting to see hemoglobin values, in light of the iron deficiency that resulted
higher in inactive CD than active CD. Secondly, prealbumin, given its shorter
halflife than that of albumin, is a very good parameter to evaluate nutritional
status.
3. Discussion is quite rough. It is absolutely necessary to have a more detailed
and critical approach to results (for example, the problem of iron deficiency is
discussed, whereas albumin deficiency is not). Then, the limitations of the study,
if any, must be clearly stated (that, actually, are completely lacking). Secondly,
any information about the duration of the study must be given in the "Methods"
section and not only rapidly mentioned in the "Discussion"(see the first paragraph
of "Discussion").
4. Pay attention to the discrepancy between saying that a result is not statistically
significant and the p value written in brackets (see the first line on page 11 in the
manuscript). Please, correct it.
MINOR ESSENTIAL REVISIONS
1. Please correct "The controls were selected from among individuals" by
deleting "from"(at the beginning of the Methods section)
DISCRETIONARY REVISIONS
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Nutritional Status of Adolescents with Crohn's Disease: A Prospective
Cross-sectional Study
Version:2Date:4 July 2015
Reviewer: Annalisa Schiepatti
Reviewer's report:
Major Compulsory Revisions
1. The problem of undernutrition/malnutrition in adolescents affected by CD is an
important one and it is clearly explained in the text. The aim of the study to
provide a snapshot of the nutritional status of CD adolescents in Brazil must be
clearly stated also in the title, abstract and discussion (not only in the last few
lines of the "Background").
2. On the basis of the present study, Brazilian adolescents affected by CD are at
nutritional risk. However, in the biochemical assessment of the nutritional status,
some important parameters are lacking: haemoglobin, prealbumin, cholesterol,
triglycerides. All these parameters are quite easy to be obtained and some of
them are of outmost importance in the baseline clinical evaluation of CD patients
and may influence clinical decisions. In particular hemoglobin because CD
patients very often suffer from anemia. Moreover, it would have been very
interesting to see hemoglobin values, in light of the iron deficiency that resulted
higher in inactive CD than active CD. Secondly, prealbumin, given its shorter
halflife than that of albumin, is a very good parameter to evaluate nutritional
status.
3. Discussion is quite rough. It is absolutely necessary to have a more detailed
and critical approach to results (for example, the problem of iron deficiency is
discussed, whereas albumin deficiency is not). Then, the limitations of the study,
if any, must be clearly stated (that, actually, are completely lacking). Secondly,
any information about the duration of the study must be given in the "Methods"
section and not only rapidly mentioned in the "Discussion"(see the first paragraph
of "Discussion").
4. Pay attention to the discrepancy between saying that a result is not statistically
significant and the p value written in brackets (see the first line on page 11 in the
manuscript). Please, correct it.
MINOR ESSENTIAL REVISIONS
1. Please correct "The controls were selected from among individuals" by
deleting "from"(at the beginning of the Methods section)
DISCRETIONARY REVISIONS
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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