Title: Effect of disease duration on fecal biomarkers in ulcerative colitis: A prospective cohort
study
Version: 0 Date: 06 Jun 2022
Reviewer's report:
Thie article written by Ishida et al. is titled "Effect of Disease Duration on Fecal biomarkers in
Ulcerative colitis". This study explored the influence of UC duration on fecal calprotectin(FC)
by calculating the correlation between FC and endoscopic scores. The article has the correct
structure, which helps to reveal all The studied issues. The presented topic is relevant.
In lines 112 to 114, the author proposed to divide the patients enrolled in cohort 1 into the group
of short and long term disease duration, and the sample size is shown in Figure 1. But the reason
for such grouping is not explained, which may confuse readers.
In lines 238 to 239, the author used receiver operating characteristic analysis(ROC analysis) to
study the predictive value of FC and FIT for mucosal healing in different groups of patients.
Still, only P values and area under the curve were listed in Table 4. Adding the Figure about
ROC Curves of FC and FIT and labelling AUC will help illustrate the point.
Endoscopy is traumatic for patients, and the evaluation results are not entirely accurate.
Therefore, it is crucial to explore new biomarkers for UC treatment. The paper is logical and
helps to reveal the problem under study.
Title: Effect of disease duration on fecal biomarkers in ulcerative colitis: A prospective cohort
study
Version: 0 Date: 06 Jun 2022
Reviewer's report:
Thie article written by Ishida et al. is titled "Effect of Disease Duration on Fecal biomarkers in
Ulcerative colitis". This study explored the influence of UC duration on fecal calprotectin(FC)
by calculating the correlation between FC and endoscopic scores. The article has the correct
structure, which helps to reveal all The studied issues. The presented topic is relevant.
In lines 112 to 114, the author proposed to divide the patients enrolled in cohort 1 into the group
of short and long term disease duration, and the sample size is shown in Figure 1. But the reason
for such grouping is not explained, which may confuse readers.
In lines 238 to 239, the author used receiver operating characteristic analysis(ROC analysis) to
study the predictive value of FC and FIT for mucosal healing in different groups of patients.
Still, only P values and area under the curve were listed in Table 4. Adding the Figure about
ROC Curves of FC and FIT and labelling AUC will help illustrate the point.
Endoscopy is traumatic for patients, and the evaluation results are not entirely accurate.
Therefore, it is crucial to explore new biomarkers for UC treatment. The paper is logical and
helps to reveal the problem under study.
Please review this paper.
user
Title: Effect of disease duration on fecal biomarkers in ulcerative colitis: A prospective cohort
study
Version: 0 Date: 06 Jun 2022
Reviewer's report:
Thie article written by Ishida et al. is titled "Effect of Disease Duration on Fecal biomarkers in
Ulcerative colitis". This study explored the influence of UC duration on fecal calprotectin(FC)
by calculating the correlation between FC and endoscopic scores. The article has the correct
structure, which helps to reveal all The studied issues. The presented topic is relevant.
In lines 112 to 114, the author proposed to divide the patients enrolled in cohort 1 into the group
of short and long term disease duration, and the sample size is shown in Figure 1. But the reason
for such grouping is not explained, which may confuse readers.
In lines 238 to 239, the author used receiver operating characteristic analysis(ROC analysis) to
study the predictive value of FC and FIT for mucosal healing in different groups of patients.
Still, only P values and area under the curve were listed in Table 4. Adding the Figure about
ROC Curves of FC and FIT and labelling AUC will help illustrate the point.
Endoscopy is traumatic for patients, and the evaluation results are not entirely accurate.
Therefore, it is crucial to explore new biomarkers for UC treatment. The paper is logical and
helps to reveal the problem under study.
assistant