Reviewer's report
Title:Lack of Guanylate Cyclase C results in increased mortality in mice
following liver injury
Version: 3Date:11 July 2010
Reviewer: Arndt Vogel
Reviewer's report:
Mann et al. resubmitted their revised manuscript in which they analyzed the role
of guanylate cyclase C for CCL4 induced liver injury in mice. Overall the
manuscript is improved, but it is still very descriptive. Nevertheless, the authors
report two interesting findings. First, the increased mortality of GC-C mice in the
mixed background following CCl4 and additionally, the increased apoptosis
sensitivity of the GC-C mice. It would be interesting to see whether the BL6 mice
also display an increased apoptosis sensitivity. Unfortunately, both findings
remain unexplained. I do not agree with the authors that the increased number of
apoptotic cells explains the increased mortality of the GC-C mice.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Lack of Guanylate Cyclase C results in increased mortality in mice
following liver injury
Version: 3Date:11 July 2010
Reviewer: Arndt Vogel
Reviewer's report:
Mann et al. resubmitted their revised manuscript in which they analyzed the role
of guanylate cyclase C for CCL4 induced liver injury in mice. Overall the
manuscript is improved, but it is still very descriptive. Nevertheless, the authors
report two interesting findings. First, the increased mortality of GC-C mice in the
mixed background following CCl4 and additionally, the increased apoptosis
sensitivity of the GC-C mice. It would be interesting to see whether the BL6 mice
also display an increased apoptosis sensitivity. Unfortunately, both findings
remain unexplained. I do not agree with the authors that the increased number of
apoptotic cells explains the increased mortality of the GC-C mice.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Lack of Guanylate Cyclase C results in increased mortality in mice
following liver injury
Version: 3Date:11 July 2010
Reviewer: Arndt Vogel
Reviewer's report:
Mann et al. resubmitted their revised manuscript in which they analyzed the role
of guanylate cyclase C for CCL4 induced liver injury in mice. Overall the
manuscript is improved, but it is still very descriptive. Nevertheless, the authors
report two interesting findings. First, the increased mortality of GC-C mice in the
mixed background following CCl4 and additionally, the increased apoptosis
sensitivity of the GC-C mice. It would be interesting to see whether the BL6 mice
also display an increased apoptosis sensitivity. Unfortunately, both findings
remain unexplained. I do not agree with the authors that the increased number of
apoptotic cells explains the increased mortality of the GC-C mice.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
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