Title: Genetic Associations of Birthweight, Childhood, and Adult BMI with
Metabolic Dysfunction-associated Steatotic liver disease: A Mendelian Randomization
Version: 1 Date: 16 Jun 2024
Reviewer:  Tarana Gupta
Reviewer's report:
Authors have done a meticulous analysis of available database for finding association of
birthweight, adult and childhood BMI with NAFLD.  I have few comments and suggestions.
1. They have taken all data for European population. The strength of the study is uniformity for
this association minimising bias due to geographical regions.  On the contrary, findings of the
study can not be generalised.
2. There is extensive statistical analysis, therefore, reviewers should include statistician to check
for robustness of methods.
Title: Genetic Associations of Birthweight, Childhood, and Adult BMI with
Metabolic Dysfunction-associated Steatotic liver disease: A Mendelian Randomization
Version: 1 Date: 16 Jun 2024
Reviewer:  Tarana Gupta
Reviewer's report:
Authors have done a meticulous analysis of available database for finding association of
birthweight, adult and childhood BMI with NAFLD.  I have few comments and suggestions.
1. They have taken all data for European population. The strength of the study is uniformity for
this association minimising bias due to geographical regions.  On the contrary, findings of the
study can not be generalised.
2. There is extensive statistical analysis, therefore, reviewers should include statistician to check
for robustness of methods.
Please review this paper.
user
Title: Genetic Associations of Birthweight, Childhood, and Adult BMI with
Metabolic Dysfunction-associated Steatotic liver disease: A Mendelian Randomization
Version: 1 Date: 16 Jun 2024
Reviewer:  Tarana Gupta
Reviewer's report:
Authors have done a meticulous analysis of available database for finding association of
birthweight, adult and childhood BMI with NAFLD.  I have few comments and suggestions.
1. They have taken all data for European population. The strength of the study is uniformity for
this association minimising bias due to geographical regions.  On the contrary, findings of the
study can not be generalised.
2. There is extensive statistical analysis, therefore, reviewers should include statistician to check
for robustness of methods.
assistant