Reviewer's report
Title:Assessment of Helicobacter pylori eradication in patients on NSAID
treatment
Version: 2Date:28 August 2012
Reviewer: Guoxin Zhang
Reviewer's report:
The manuscript entitled “Assessment of Helicobacter pylori eradication in
patients on NSAID treatment” by HE Vonkeman et al presents a post-hoc
investigation into H. pylori IgG-antibody titer changes following H. pylori
eradication therapy in NSAID users. They concluded that in NSAID using
patients, following H. pylori eradication therapy or placebo, histological
examination of gastric mucosal tissue biopsies provided the best sensitivity and
specificity ratios for evaluating success of H. pylori eradication therapy, and a
percentual H. pylori IgG-antibody titer change has better sensitivity and
specificity than an absolute titer change or a predefined H. pylori IgGantibody
titer cut-off point for evaluating success of H. pylori eradication therapy. The
study is globally well performed, however, several points are incomplete.
- Major Compulsory Revisions
1. The authors found that histological examination provided the best sensitivity
and specificity ratios for evaluating success of H. pylori eradication therapy in
NSAID using patients. It should be discussed in the section of discussion.
2. Can authors consider the sensitivity and specificity of different tests of H. pylori
in NSAID-naïve patients in comparison with NSAID users in sub-analysis?
3. PPI usage may obtain false negative results, however, we didn’t see if there
was PPI usage in two groups of H. pylori eradication therapy and placebo.
4. In discussion section, NSAID using did not seem to influence H. pylori
eradication rates or serological testing for H. pylori, but they only selected
patients with NSAID using. It would be better if there are results from the group of
NSAID using and the group of non- NSAID using.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Reviewer's report
Title:Assessment of Helicobacter pylori eradication in patients on NSAID
treatment
Version: 2Date:28 August 2012
Reviewer: Guoxin Zhang
Reviewer's report:
The manuscript entitled “Assessment of Helicobacter pylori eradication in
patients on NSAID treatment” by HE Vonkeman et al presents a post-hoc
investigation into H. pylori IgG-antibody titer changes following H. pylori
eradication therapy in NSAID users. They concluded that in NSAID using
patients, following H. pylori eradication therapy or placebo, histological
examination of gastric mucosal tissue biopsies provided the best sensitivity and
specificity ratios for evaluating success of H. pylori eradication therapy, and a
percentual H. pylori IgG-antibody titer change has better sensitivity and
specificity than an absolute titer change or a predefined H. pylori IgGantibody
titer cut-off point for evaluating success of H. pylori eradication therapy. The
study is globally well performed, however, several points are incomplete.
- Major Compulsory Revisions
1. The authors found that histological examination provided the best sensitivity
and specificity ratios for evaluating success of H. pylori eradication therapy in
NSAID using patients. It should be discussed in the section of discussion.
2. Can authors consider the sensitivity and specificity of different tests of H. pylori
in NSAID-naïve patients in comparison with NSAID users in sub-analysis?
3. PPI usage may obtain false negative results, however, we didn’t see if there
was PPI usage in two groups of H. pylori eradication therapy and placebo.
4. In discussion section, NSAID using did not seem to influence H. pylori
eradication rates or serological testing for H. pylori, but they only selected
patients with NSAID using. It would be better if there are results from the group of
NSAID using and the group of non- NSAID using.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Please review this paper.
user
Reviewer's report
Title:Assessment of Helicobacter pylori eradication in patients on NSAID
treatment
Version: 2Date:28 August 2012
Reviewer: Guoxin Zhang
Reviewer's report:
The manuscript entitled “Assessment of Helicobacter pylori eradication in
patients on NSAID treatment” by HE Vonkeman et al presents a post-hoc
investigation into H. pylori IgG-antibody titer changes following H. pylori
eradication therapy in NSAID users. They concluded that in NSAID using
patients, following H. pylori eradication therapy or placebo, histological
examination of gastric mucosal tissue biopsies provided the best sensitivity and
specificity ratios for evaluating success of H. pylori eradication therapy, and a
percentual H. pylori IgG-antibody titer change has better sensitivity and
specificity than an absolute titer change or a predefined H. pylori IgGantibody
titer cut-off point for evaluating success of H. pylori eradication therapy. The
study is globally well performed, however, several points are incomplete.
- Major Compulsory Revisions
1. The authors found that histological examination provided the best sensitivity
and specificity ratios for evaluating success of H. pylori eradication therapy in
NSAID using patients. It should be discussed in the section of discussion.
2. Can authors consider the sensitivity and specificity of different tests of H. pylori
in NSAID-naïve patients in comparison with NSAID users in sub-analysis?
3. PPI usage may obtain false negative results, however, we didn’t see if there
was PPI usage in two groups of H. pylori eradication therapy and placebo.
4. In discussion section, NSAID using did not seem to influence H. pylori
eradication rates or serological testing for H. pylori, but they only selected
patients with NSAID using. It would be better if there are results from the group of
NSAID using and the group of non- NSAID using.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
assistant