Title: Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients
Version: 3 Date: 06 Dec 2024
Reviewer:  Eleonora Lai
Reviewer's report:
"Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients" is a well written manuscript assessing the
role of some easy-to-assess parameters in predicting survival in untreated metastatic colorectal
cancer patients. The authors provided a consistent background and clearly explained their
methods. Results are well presented and critically discussed in the appropriate section. The study
has its limitations, especially the retrospective nature. Moreover, a specific research might be
performed in the subgroup of liver-only disease patients. However, it has a good point as a
starting idea for further prospective studies to validate the prognostic value of the parameters
assessed
Title: Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients
Version: 3 Date: 06 Dec 2024
Reviewer:  Eleonora Lai
Reviewer's report:
"Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients" is a well written manuscript assessing the
role of some easy-to-assess parameters in predicting survival in untreated metastatic colorectal
cancer patients. The authors provided a consistent background and clearly explained their
methods. Results are well presented and critically discussed in the appropriate section. The study
has its limitations, especially the retrospective nature. Moreover, a specific research might be
performed in the subgroup of liver-only disease patients. However, it has a good point as a
starting idea for further prospective studies to validate the prognostic value of the parameters
assessed
Please review this paper.
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Title: Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients
Version: 3 Date: 06 Dec 2024
Reviewer:  Eleonora Lai
Reviewer's report:
"Predictive value of the FIB-4 index, APRI, ALBI score, and GPR for overall survival in
treatment-naïve metastatic colorectal cancer patients" is a well written manuscript assessing the
role of some easy-to-assess parameters in predicting survival in untreated metastatic colorectal
cancer patients. The authors provided a consistent background and clearly explained their
methods. Results are well presented and critically discussed in the appropriate section. The study
has its limitations, especially the retrospective nature. Moreover, a specific research might be
performed in the subgroup of liver-only disease patients. However, it has a good point as a
starting idea for further prospective studies to validate the prognostic value of the parameters
assessed
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