Reviewer's report
Title:Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the
survival rates after intestinal ischemia reperfusion injury in rats
Version: 1Date:24 March 2008
Reviewer: Saburo Horikawa
Reviewer's report:
Major Compulsory Revisins
This article is of considerable interest and potential importance in demonstrating
therapeutic strategies for intestinal ischemia and reperfusion injury. This
experiment is well designed and conducted, however, the manuscript is not
adequately arranged.
Major points.
1. In "Results" section, figures (Figure 3, 4, 5 and 6) are not adequately arranged
as seen in completed manuscript. It is difficult to estimate the significance of the
results described by authors in the text.
2. In "Materials and Methods" section, the subsection of "Immunohistochemical
detection of tryptase in intestine" exists. Which section can we find the figure or
interpretation of the result?
Minor points.
3. In page 7, first paragraph.
Concerning to the description of "The surviving rats---- after 75 min intestine
ischemia", sham-operated group does not undergo a 75 min ischemia.
4.In addition, there are several (many) misspellings and wrong use of a term.
For example, Cromolun Sdium (Cromolyn Sodium) et al.
Please carefully check the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the
survival rates after intestinal ischemia reperfusion injury in rats
Version: 1Date:24 March 2008
Reviewer: Saburo Horikawa
Reviewer's report:
Major Compulsory Revisins
This article is of considerable interest and potential importance in demonstrating
therapeutic strategies for intestinal ischemia and reperfusion injury. This
experiment is well designed and conducted, however, the manuscript is not
adequately arranged.
Major points.
1. In "Results" section, figures (Figure 3, 4, 5 and 6) are not adequately arranged
as seen in completed manuscript. It is difficult to estimate the significance of the
results described by authors in the text.
2. In "Materials and Methods" section, the subsection of "Immunohistochemical
detection of tryptase in intestine" exists. Which section can we find the figure or
interpretation of the result?
Minor points.
3. In page 7, first paragraph.
Concerning to the description of "The surviving rats---- after 75 min intestine
ischemia", sham-operated group does not undergo a 75 min ischemia.
4.In addition, there are several (many) misspellings and wrong use of a term.
For example, Cromolun Sdium (Cromolyn Sodium) et al.
Please carefully check the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Influence of Ketotifen, Cromolyn Sodium, and Compound 48/80 on the
survival rates after intestinal ischemia reperfusion injury in rats
Version: 1Date:24 March 2008
Reviewer: Saburo Horikawa
Reviewer's report:
Major Compulsory Revisins
This article is of considerable interest and potential importance in demonstrating
therapeutic strategies for intestinal ischemia and reperfusion injury. This
experiment is well designed and conducted, however, the manuscript is not
adequately arranged.
Major points.
1. In "Results" section, figures (Figure 3, 4, 5 and 6) are not adequately arranged
as seen in completed manuscript. It is difficult to estimate the significance of the
results described by authors in the text.
2. In "Materials and Methods" section, the subsection of "Immunohistochemical
detection of tryptase in intestine" exists. Which section can we find the figure or
interpretation of the result?
Minor points.
3. In page 7, first paragraph.
Concerning to the description of "The surviving rats---- after 75 min intestine
ischemia", sham-operated group does not undergo a 75 min ischemia.
4.In addition, there are several (many) misspellings and wrong use of a term.
For example, Cromolun Sdium (Cromolyn Sodium) et al.
Please carefully check the manuscript.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant