Reviewer's report
Title:Gastric Outlet Obstruction from Metastatic Lobular Breast Carcinoma
Version:3Date:16 June 2015
Reviewer: Manju Chandrasegaram
Reviewer's report:
I am not sure oestrogen receptor positivity alone can guarantee the diagnosis of
metastatic lobular breast cancer – several upper GI cancers including
oesophageal cancer can express oestrogen receptors – so the diagnosis of
lobular breast cancer histologically needs to be expanded through other findings
as illustrated in the figures. Oestrogen receptor positivity is also found in normal
liver, and benign liver tumours.
In the background causes of gastric outlet obstruction, peptic ulcer disease as a
broad category should be included, as this is more common than gallstone as a
cause.
line 13 page 2 – referred to the gastroenterology team or unit rather than the
specialty line 14 GERD – acronym not previously defined in the text line 18 seen
by the oncology team or unit rather than the specialty line 23 EGD not previously
defined
Reviewer's report
Title:Gastric Outlet Obstruction from Metastatic Lobular Breast Carcinoma
Version:3Date:16 June 2015
Reviewer: Manju Chandrasegaram
Reviewer's report:
I am not sure oestrogen receptor positivity alone can guarantee the diagnosis of
metastatic lobular breast cancer – several upper GI cancers including
oesophageal cancer can express oestrogen receptors – so the diagnosis of
lobular breast cancer histologically needs to be expanded through other findings
as illustrated in the figures. Oestrogen receptor positivity is also found in normal
liver, and benign liver tumours.
In the background causes of gastric outlet obstruction, peptic ulcer disease as a
broad category should be included, as this is more common than gallstone as a
cause.
line 13 page 2 – referred to the gastroenterology team or unit rather than the
specialty line 14 GERD – acronym not previously defined in the text line 18 seen
by the oncology team or unit rather than the specialty line 23 EGD not previously
defined
Please review this paper.
user
Reviewer's report
Title:Gastric Outlet Obstruction from Metastatic Lobular Breast Carcinoma
Version:3Date:16 June 2015
Reviewer: Manju Chandrasegaram
Reviewer's report:
I am not sure oestrogen receptor positivity alone can guarantee the diagnosis of
metastatic lobular breast cancer – several upper GI cancers including
oesophageal cancer can express oestrogen receptors – so the diagnosis of
lobular breast cancer histologically needs to be expanded through other findings
as illustrated in the figures. Oestrogen receptor positivity is also found in normal
liver, and benign liver tumours.
In the background causes of gastric outlet obstruction, peptic ulcer disease as a
broad category should be included, as this is more common than gallstone as a
cause.
line 13 page 2 – referred to the gastroenterology team or unit rather than the
specialty line 14 GERD – acronym not previously defined in the text line 18 seen
by the oncology team or unit rather than the specialty line 23 EGD not previously
defined
assistant