Reviewer ’s report  
 
Title: Elevated serum triglyceride and low -density lipoprotein cho lesterol promotes the 
formation of colorectal polyps  
 
Version: 0 Date: 21 Jul 2018  
 
Reviewer: Surasak Sangkhathat  
 
Reviewer's report:  
 
It is a good idea to study the association between dyslipidemia and the occurrence of colorectal 
polyp. However, the methodology in this study may not be adequate for drawing a conclusion.  
 
1. Using healthy and asymptomatic controls without a colonoscopy is not acceptable. A polyp 
may occur although there is no symptom at all. Besides, age and body weight  between the cases 
and the controls were not comparable. For the reason, it is not fair to conclude that 
hyperlipidemia was related with the occurrence of polyp as it can be the difference between the 
elder/the younger or the obese/the non -obese or females /males.  
 
2. Table 3, the difference of LDL -C level between the cases with polyp has been shown earlier in 
the Table 2. There is no need to repeat in this Table.  
 
In conclusion, problem of the study is at the design is not adequate to answer the research 
question, filled of confounders. English is good but the data display has a large room to do. My 
suggestion is to use the cases who underwent a colonoscopy without polyp detected as controls. 
The one with cancer, previous surgery and other diseases should b e excluded at the first place as 
this study aimed to see the difference of lipid profiles in general people.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to th e authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years receive d reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way ga in or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4. Have you received reimbursements, fees, funding, or sala ry from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answ er no to all of the above, write 'I declare that I have  no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be ma de available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, wh ich will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Elevated serum triglyceride and low -density lipoprotein cho lesterol promotes the 
formation of colorectal polyps  
 
Version: 0 Date: 21 Jul 2018  
 
Reviewer: Surasak Sangkhathat  
 
Reviewer's report:  
 
It is a good idea to study the association between dyslipidemia and the occurrence of colorectal 
polyp. However, the methodology in this study may not be adequate for drawing a conclusion.  
 
1. Using healthy and asymptomatic controls without a colonoscopy is not acceptable. A polyp 
may occur although there is no symptom at all. Besides, age and body weight  between the cases 
and the controls were not comparable. For the reason, it is not fair to conclude that 
hyperlipidemia was related with the occurrence of polyp as it can be the difference between the 
elder/the younger or the obese/the non -obese or females /males.  
 
2. Table 3, the difference of LDL -C level between the cases with polyp has been shown earlier in 
the Table 2. There is no need to repeat in this Table.  
 
In conclusion, problem of the study is at the design is not adequate to answer the research 
question, filled of confounders. English is good but the data display has a large room to do. My 
suggestion is to use the cases who underwent a colonoscopy without polyp detected as controls. 
The one with cancer, previous surgery and other diseases should b e excluded at the first place as 
this study aimed to see the difference of lipid profiles in general people.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to th e authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years receive d reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way ga in or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4. Have you received reimbursements, fees, funding, or sala ry from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answ er no to all of the above, write 'I declare that I have  no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be ma de available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, wh ich will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Elevated serum triglyceride and low -density lipoprotein cho lesterol promotes the 
formation of colorectal polyps  
 
Version: 0 Date: 21 Jul 2018  
 
Reviewer: Surasak Sangkhathat  
 
Reviewer's report:  
 
It is a good idea to study the association between dyslipidemia and the occurrence of colorectal 
polyp. However, the methodology in this study may not be adequate for drawing a conclusion.  
 
1. Using healthy and asymptomatic controls without a colonoscopy is not acceptable. A polyp 
may occur although there is no symptom at all. Besides, age and body weight  between the cases 
and the controls were not comparable. For the reason, it is not fair to conclude that 
hyperlipidemia was related with the occurrence of polyp as it can be the difference between the 
elder/the younger or the obese/the non -obese or females /males.  
 
2. Table 3, the difference of LDL -C level between the cases with polyp has been shown earlier in 
the Table 2. There is no need to repeat in this Table.  
 
In conclusion, problem of the study is at the design is not adequate to answer the research 
question, filled of confounders. English is good but the data display has a large room to do. My 
suggestion is to use the cases who underwent a colonoscopy without polyp detected as controls. 
The one with cancer, previous surgery and other diseases should b e excluded at the first place as 
this study aimed to see the difference of lipid profiles in general people.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to th e authors.  
 
No 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
No 
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years receive d reimbursements, f ees, funding, or salary 
from an organisation that may in any way gain or lose financial ly from the 
publication of this manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way ga in or 
lose financially from the publication of this manuscript, either now or in the 
future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content 
of the manuscript?  
 
4. Have you received reimbursements, fees, funding, or sala ry from an organization 
that holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answ er no to all of the above, write 'I declare that I have  no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be ma de available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editors, wh ich will not be published.  
 
I agree to the open peer review policy of the journal  
assistant