Reviewer's report
Title:Hepatic stellate cells: central modulators of hepatic carcinogenesis
Version:2Date:11 April 2015
Reviewer: Diego F Calvisi
Reviewer's report:
In the present review article, Thompson et al. summarized the current knowledge
on the link between hepatic stellate cells (HSC), the major source of extracellular
proteins during fibrogenesis, and hepatocarcinogenesis. In particular, the authors
focused on the molecular mechanisms whereby HSC modulate hepatocellular
carcinoma (HCC) growth, immune cell evasion and angiogenesis. In addition, the
authors describe the mechanistic crosstalk between HSC and HCC, and the
novel strategies developed to target HSC for the treatment of human HCC.
The work by Thompson et al. is an excellent, well-written review article on this
important topic. The review presents a comprehensive, authoritative review of the
existing work in this area. The appropriate references are cited, and all
statements of fact accompanied by a reference.
Besides a comprehensive summary, the authors elegantly discussed the most
recent strategies and therapeutic possibility of targeting HSC in human liver
cancer.
I would kindly suggest the authors few, minor modifications.
Discretionary Revisions:
1. The authors should include a table in which the major molecular targets of the
HSC-HCC crosstalk (and the presumable role of these targets) are summarized.
2. The authors should add a scheme where the innovative therapeutic
approaches targeting HSC and the related challenges ae summarized.
Level of interest: An exceptional article
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Hepatic stellate cells: central modulators of hepatic carcinogenesis
Version:2Date:11 April 2015
Reviewer: Diego F Calvisi
Reviewer's report:
In the present review article, Thompson et al. summarized the current knowledge
on the link between hepatic stellate cells (HSC), the major source of extracellular
proteins during fibrogenesis, and hepatocarcinogenesis. In particular, the authors
focused on the molecular mechanisms whereby HSC modulate hepatocellular
carcinoma (HCC) growth, immune cell evasion and angiogenesis. In addition, the
authors describe the mechanistic crosstalk between HSC and HCC, and the
novel strategies developed to target HSC for the treatment of human HCC.
The work by Thompson et al. is an excellent, well-written review article on this
important topic. The review presents a comprehensive, authoritative review of the
existing work in this area. The appropriate references are cited, and all
statements of fact accompanied by a reference.
Besides a comprehensive summary, the authors elegantly discussed the most
recent strategies and therapeutic possibility of targeting HSC in human liver
cancer.
I would kindly suggest the authors few, minor modifications.
Discretionary Revisions:
1. The authors should include a table in which the major molecular targets of the
HSC-HCC crosstalk (and the presumable role of these targets) are summarized.
2. The authors should add a scheme where the innovative therapeutic
approaches targeting HSC and the related challenges ae summarized.
Level of interest: An exceptional article
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Hepatic stellate cells: central modulators of hepatic carcinogenesis
Version:2Date:11 April 2015
Reviewer: Diego F Calvisi
Reviewer's report:
In the present review article, Thompson et al. summarized the current knowledge
on the link between hepatic stellate cells (HSC), the major source of extracellular
proteins during fibrogenesis, and hepatocarcinogenesis. In particular, the authors
focused on the molecular mechanisms whereby HSC modulate hepatocellular
carcinoma (HCC) growth, immune cell evasion and angiogenesis. In addition, the
authors describe the mechanistic crosstalk between HSC and HCC, and the
novel strategies developed to target HSC for the treatment of human HCC.
The work by Thompson et al. is an excellent, well-written review article on this
important topic. The review presents a comprehensive, authoritative review of the
existing work in this area. The appropriate references are cited, and all
statements of fact accompanied by a reference.
Besides a comprehensive summary, the authors elegantly discussed the most
recent strategies and therapeutic possibility of targeting HSC in human liver
cancer.
I would kindly suggest the authors few, minor modifications.
Discretionary Revisions:
1. The authors should include a table in which the major molecular targets of the
HSC-HCC crosstalk (and the presumable role of these targets) are summarized.
2. The authors should add a scheme where the innovative therapeutic
approaches targeting HSC and the related challenges ae summarized.
Level of interest: An exceptional article
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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