Title: Body Posture Can Modulate Liver Stiffness Measured by Transient Elastography: A
Prospective Observational Study
Version: 2 Date: 26 Sep 2024
Reviewer:  Arthur de Sá Ferreira
Reviewer's report:
Comments
This manuscript reports an observational study investigating the effects of body posture (supine,
seated, upright) on liver stiffness in people with chronic liver disease and healthy subjects.
The study's rationale is well-posed, suggesting body posture may be a confounding factor
in estimating liver stiffness. Procedures seem sufficiently described to allow replication and
adequately used randomization of positions and blinding of examiners where possible. Statistical
analysis is adequate to the study’s aim and procedures. As recommended, results are reported
using point data, group summary, and distributions. Discussion section covers the clinical
implications and limitations/strengths of this study. I have only a few minor comments for the
authors to consider.
Minor comments
1. Study population. Please report what software was used for sample size determination, it is
important to give the authors credit. Based on the reporting I assume it was G*Power.
2. Figure 5. Consider presenting these results as in Figure 3.
Title: Body Posture Can Modulate Liver Stiffness Measured by Transient Elastography: A
Prospective Observational Study
Version: 2 Date: 26 Sep 2024
Reviewer:  Arthur de Sá Ferreira
Reviewer's report:
Comments
This manuscript reports an observational study investigating the effects of body posture (supine,
seated, upright) on liver stiffness in people with chronic liver disease and healthy subjects.
The study's rationale is well-posed, suggesting body posture may be a confounding factor
in estimating liver stiffness. Procedures seem sufficiently described to allow replication and
adequately used randomization of positions and blinding of examiners where possible. Statistical
analysis is adequate to the study’s aim and procedures. As recommended, results are reported
using point data, group summary, and distributions. Discussion section covers the clinical
implications and limitations/strengths of this study. I have only a few minor comments for the
authors to consider.
Minor comments
1. Study population. Please report what software was used for sample size determination, it is
important to give the authors credit. Based on the reporting I assume it was G*Power.
2. Figure 5. Consider presenting these results as in Figure 3.
Please review this paper.
user
Title: Body Posture Can Modulate Liver Stiffness Measured by Transient Elastography: A
Prospective Observational Study
Version: 2 Date: 26 Sep 2024
Reviewer:  Arthur de Sá Ferreira
Reviewer's report:
Comments
This manuscript reports an observational study investigating the effects of body posture (supine,
seated, upright) on liver stiffness in people with chronic liver disease and healthy subjects.
The study's rationale is well-posed, suggesting body posture may be a confounding factor
in estimating liver stiffness. Procedures seem sufficiently described to allow replication and
adequately used randomization of positions and blinding of examiners where possible. Statistical
analysis is adequate to the study’s aim and procedures. As recommended, results are reported
using point data, group summary, and distributions. Discussion section covers the clinical
implications and limitations/strengths of this study. I have only a few minor comments for the
authors to consider.
Minor comments
1. Study population. Please report what software was used for sample size determination, it is
important to give the authors credit. Based on the reporting I assume it was G*Power.
2. Figure 5. Consider presenting these results as in Figure 3.
assistant