Reviewer's report
Title:Images of colonic real-time tissue elastography correlate with those of
colonoscopy and may predict response to therapy in patients with ulcerative
colitis
Version: 1Date:11 December 2010
Reviewer: Svein Odegaard
Reviewer's report:
The paper is well written and the scientific part is relevant, however I have some
major and some minor comments.
1. Elastography may be performed using different imaging techniques, thus the
term "sonoelastography" should probably appear in the title of the paper.
2. Figures 1 and 2 should be omited and replaced by a B-mode ultrasound image
of the normal colon wall with its differt layers (at least the 5 layer structure, which
should be clearly described and labeled). Furthermore, the correponding EG of
the normal wall and the layers should be shown indicating the different colours
which usually are seen for mucosa, submucosa and muscularis propria.
3. There is a difference in ultrasound layers and EG interpretation when the GI
wall is imaged from the muscularis propria side or from the intraluminal side (e.g.
the dorsal wall of the colon).
4. What ultrasound frequency is used?
5. Why is the pressure indicator not seen on the dual image (is normally seen on
this equipment). The pressure influences on GI wall thickness, echogenicity and
individual wall layers.
6. 4 mm is a thick wall in this part of the colon.
7. Figure 3 A is not good, the B-image is too dark and the GI wall is not easily
seen. Why not white arrows? The arrows on the EG image is partly out of
position. Figure 3B is also not correctly interpreted because two GI loops are
close to each other adding two muscle layers in the area which is indicated by
arrows on the EG-image.Fig 3C, the B-image cannot be interpreted. Figure 3D.
B-mode image is not good, however, EG indicates a harder area.
8. Figure 4C looks more like Crohn's disease (?).
9. Reference 10. Only the first author seems to have his family name, the others
are probably given their first name which I think might be an error.
10. The authors have used the default setting on the ultrasound maschine.
Several possibilities to adjust the parameters are available and may be helpful in
EG imaging e.g. E-dyn setting.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I am working in this field, mainly using endoscopic ultrasound in the evaluation of
gastrointestinal cancer and other tumours. I also use ultrasound,
sonoelastography, contrast enhanced ultrasound in the characterization of
inflammatory and malignant disorders. However, I think the authors of this paper
will accept that my comments are relevant and the paper has no influence on my
work and.
Reviewer's report
Title:Images of colonic real-time tissue elastography correlate with those of
colonoscopy and may predict response to therapy in patients with ulcerative
colitis
Version: 1Date:11 December 2010
Reviewer: Svein Odegaard
Reviewer's report:
The paper is well written and the scientific part is relevant, however I have some
major and some minor comments.
1. Elastography may be performed using different imaging techniques, thus the
term "sonoelastography" should probably appear in the title of the paper.
2. Figures 1 and 2 should be omited and replaced by a B-mode ultrasound image
of the normal colon wall with its differt layers (at least the 5 layer structure, which
should be clearly described and labeled). Furthermore, the correponding EG of
the normal wall and the layers should be shown indicating the different colours
which usually are seen for mucosa, submucosa and muscularis propria.
3. There is a difference in ultrasound layers and EG interpretation when the GI
wall is imaged from the muscularis propria side or from the intraluminal side (e.g.
the dorsal wall of the colon).
4. What ultrasound frequency is used?
5. Why is the pressure indicator not seen on the dual image (is normally seen on
this equipment). The pressure influences on GI wall thickness, echogenicity and
individual wall layers.
6. 4 mm is a thick wall in this part of the colon.
7. Figure 3 A is not good, the B-image is too dark and the GI wall is not easily
seen. Why not white arrows? The arrows on the EG image is partly out of
position. Figure 3B is also not correctly interpreted because two GI loops are
close to each other adding two muscle layers in the area which is indicated by
arrows on the EG-image.Fig 3C, the B-image cannot be interpreted. Figure 3D.
B-mode image is not good, however, EG indicates a harder area.
8. Figure 4C looks more like Crohn's disease (?).
9. Reference 10. Only the first author seems to have his family name, the others
are probably given their first name which I think might be an error.
10. The authors have used the default setting on the ultrasound maschine.
Several possibilities to adjust the parameters are available and may be helpful in
EG imaging e.g. E-dyn setting.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I am working in this field, mainly using endoscopic ultrasound in the evaluation of
gastrointestinal cancer and other tumours. I also use ultrasound,
sonoelastography, contrast enhanced ultrasound in the characterization of
inflammatory and malignant disorders. However, I think the authors of this paper
will accept that my comments are relevant and the paper has no influence on my
work and.
Please review this paper.
user
Reviewer's report
Title:Images of colonic real-time tissue elastography correlate with those of
colonoscopy and may predict response to therapy in patients with ulcerative
colitis
Version: 1Date:11 December 2010
Reviewer: Svein Odegaard
Reviewer's report:
The paper is well written and the scientific part is relevant, however I have some
major and some minor comments.
1. Elastography may be performed using different imaging techniques, thus the
term "sonoelastography" should probably appear in the title of the paper.
2. Figures 1 and 2 should be omited and replaced by a B-mode ultrasound image
of the normal colon wall with its differt layers (at least the 5 layer structure, which
should be clearly described and labeled). Furthermore, the correponding EG of
the normal wall and the layers should be shown indicating the different colours
which usually are seen for mucosa, submucosa and muscularis propria.
3. There is a difference in ultrasound layers and EG interpretation when the GI
wall is imaged from the muscularis propria side or from the intraluminal side (e.g.
the dorsal wall of the colon).
4. What ultrasound frequency is used?
5. Why is the pressure indicator not seen on the dual image (is normally seen on
this equipment). The pressure influences on GI wall thickness, echogenicity and
individual wall layers.
6. 4 mm is a thick wall in this part of the colon.
7. Figure 3 A is not good, the B-image is too dark and the GI wall is not easily
seen. Why not white arrows? The arrows on the EG image is partly out of
position. Figure 3B is also not correctly interpreted because two GI loops are
close to each other adding two muscle layers in the area which is indicated by
arrows on the EG-image.Fig 3C, the B-image cannot be interpreted. Figure 3D.
B-mode image is not good, however, EG indicates a harder area.
8. Figure 4C looks more like Crohn's disease (?).
9. Reference 10. Only the first author seems to have his family name, the others
are probably given their first name which I think might be an error.
10. The authors have used the default setting on the ultrasound maschine.
Several possibilities to adjust the parameters are available and may be helpful in
EG imaging e.g. E-dyn setting.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I am working in this field, mainly using endoscopic ultrasound in the evaluation of
gastrointestinal cancer and other tumours. I also use ultrasound,
sonoelastography, contrast enhanced ultrasound in the characterization of
inflammatory and malignant disorders. However, I think the authors of this paper
will accept that my comments are relevant and the paper has no influence on my
work and.
assistant