Reviewer's report
Title:A novel scoring system for prognostic prediction in
d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure BALB/c
mice
Version: 1Date:11 September 2009
Reviewer: Justin Nguyen
Reviewer's report:
The authors posed an important question, designed the study well, and applied
sound methods to analyze the data. The data are sound. However, I do have a
few questions including the ones on the limitations of the study.
1. Many institutions do not allow the use of “dead” of the study animals to be the
endpoints. Would you please clarify how you define the premortum
characteristics including clinical behaviors to select the surviving and dead
animals in your study.
2. DSI appears to be potentially promising. However, at what time points in the
clinical course of the patients with FHF would the equation be applicable? Would
you predict that is there a possible time point in the course of FHF that DSI would
not be effective or predictive such as if the equation is applied after 12 or 24
hours since the induction or onset of FHF? Are there any other limitations of this
study?
3. I would like to see a table documenting the biochemical profile including ALT,
INR, Glucose, T-bil, urea, phosphate, and b-hydroxybutyrate levels of the 2
surviving and dead groups at 6 hours after Gal-LPS induction. In the table, the
Cliché and Kings’ Colleage Hospital criteria should be included.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
declare that I have no competing interests' below
Reviewer's report
Title:A novel scoring system for prognostic prediction in
d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure BALB/c
mice
Version: 1Date:11 September 2009
Reviewer: Justin Nguyen
Reviewer's report:
The authors posed an important question, designed the study well, and applied
sound methods to analyze the data. The data are sound. However, I do have a
few questions including the ones on the limitations of the study.
1. Many institutions do not allow the use of “dead” of the study animals to be the
endpoints. Would you please clarify how you define the premortum
characteristics including clinical behaviors to select the surviving and dead
animals in your study.
2. DSI appears to be potentially promising. However, at what time points in the
clinical course of the patients with FHF would the equation be applicable? Would
you predict that is there a possible time point in the course of FHF that DSI would
not be effective or predictive such as if the equation is applied after 12 or 24
hours since the induction or onset of FHF? Are there any other limitations of this
study?
3. I would like to see a table documenting the biochemical profile including ALT,
INR, Glucose, T-bil, urea, phosphate, and b-hydroxybutyrate levels of the 2
surviving and dead groups at 6 hours after Gal-LPS induction. In the table, the
Cliché and Kings’ Colleage Hospital criteria should be included.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
declare that I have no competing interests' below
Please review this paper.
user
Reviewer's report
Title:A novel scoring system for prognostic prediction in
d-galactosamine/lipopolysaccharide-induced fulminant hepatic failure BALB/c
mice
Version: 1Date:11 September 2009
Reviewer: Justin Nguyen
Reviewer's report:
The authors posed an important question, designed the study well, and applied
sound methods to analyze the data. The data are sound. However, I do have a
few questions including the ones on the limitations of the study.
1. Many institutions do not allow the use of “dead” of the study animals to be the
endpoints. Would you please clarify how you define the premortum
characteristics including clinical behaviors to select the surviving and dead
animals in your study.
2. DSI appears to be potentially promising. However, at what time points in the
clinical course of the patients with FHF would the equation be applicable? Would
you predict that is there a possible time point in the course of FHF that DSI would
not be effective or predictive such as if the equation is applied after 12 or 24
hours since the induction or onset of FHF? Are there any other limitations of this
study?
3. I would like to see a table documenting the biochemical profile including ALT,
INR, Glucose, T-bil, urea, phosphate, and b-hydroxybutyrate levels of the 2
surviving and dead groups at 6 hours after Gal-LPS induction. In the table, the
Cliché and Kings’ Colleage Hospital criteria should be included.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
declare that I have no competing interests' below
assistant