Title: HCV and HBV Genotypes: Vital in the Progression of HCV/ HBV Co-Infection
Version: 4 Date: 22 Nov 2024
Reviewer:  Haidi Karam-Allah Ramadan
Reviewer's report:
The article addresses the frequency or prevalence of HCV/HBV co-infection and the impact
of HCV/HBV co-infection on the progression of liver damage. Some comments are to be
addressed:
1. In the title: how did the authors assess the impact of genotypes on liver disease progression?
they did not evaluate liver stiffness  or FIB-4 or APRI scores or liver biopsy?
2. In abstract: the authors mentioned that the prevalence of HCV and HBV was done using ALT
assay for confirmation. ALT level does not diagnose viral etiology.
Also,  results on genotypes are  very deficient with no results of viral load.
3. In patients and methods: were the patients DAAs naive or experienced?  did they have
assessment for cirrhosis using ultrasound? please illustrate.
4. What is the type of statistical test used in table 2?
5.  Correlation analysis or logistic regression should be used to confirm the relation between
viral load and viral genotypes rather than Chi square or ANOVA test.
6. In discussion: female patients usually have clearance of HCV infection as you mentioned in
reference 24, 25. How your results showed high prevalence in females?
7. In conclusion: the authors mentioned "The timely detection of viral coinfection could improve
the disease treatment outcomes and enhance the overall survival of the patient", however, in this
study they did not evaluate the treatment outcomes or the survival, so the conclusion is irrelevant
to the aim and methodology of the study.
Title: HCV and HBV Genotypes: Vital in the Progression of HCV/ HBV Co-Infection
Version: 4 Date: 22 Nov 2024
Reviewer:  Haidi Karam-Allah Ramadan
Reviewer's report:
The article addresses the frequency or prevalence of HCV/HBV co-infection and the impact
of HCV/HBV co-infection on the progression of liver damage. Some comments are to be
addressed:
1. In the title: how did the authors assess the impact of genotypes on liver disease progression?
they did not evaluate liver stiffness  or FIB-4 or APRI scores or liver biopsy?
2. In abstract: the authors mentioned that the prevalence of HCV and HBV was done using ALT
assay for confirmation. ALT level does not diagnose viral etiology.
Also,  results on genotypes are  very deficient with no results of viral load.
3. In patients and methods: were the patients DAAs naive or experienced?  did they have
assessment for cirrhosis using ultrasound? please illustrate.
4. What is the type of statistical test used in table 2?
5.  Correlation analysis or logistic regression should be used to confirm the relation between
viral load and viral genotypes rather than Chi square or ANOVA test.
6. In discussion: female patients usually have clearance of HCV infection as you mentioned in
reference 24, 25. How your results showed high prevalence in females?
7. In conclusion: the authors mentioned "The timely detection of viral coinfection could improve
the disease treatment outcomes and enhance the overall survival of the patient", however, in this
study they did not evaluate the treatment outcomes or the survival, so the conclusion is irrelevant
to the aim and methodology of the study.
Please review this paper.
user
Title: HCV and HBV Genotypes: Vital in the Progression of HCV/ HBV Co-Infection
Version: 4 Date: 22 Nov 2024
Reviewer:  Haidi Karam-Allah Ramadan
Reviewer's report:
The article addresses the frequency or prevalence of HCV/HBV co-infection and the impact
of HCV/HBV co-infection on the progression of liver damage. Some comments are to be
addressed:
1. In the title: how did the authors assess the impact of genotypes on liver disease progression?
they did not evaluate liver stiffness  or FIB-4 or APRI scores or liver biopsy?
2. In abstract: the authors mentioned that the prevalence of HCV and HBV was done using ALT
assay for confirmation. ALT level does not diagnose viral etiology.
Also,  results on genotypes are  very deficient with no results of viral load.
3. In patients and methods: were the patients DAAs naive or experienced?  did they have
assessment for cirrhosis using ultrasound? please illustrate.
4. What is the type of statistical test used in table 2?
5.  Correlation analysis or logistic regression should be used to confirm the relation between
viral load and viral genotypes rather than Chi square or ANOVA test.
6. In discussion: female patients usually have clearance of HCV infection as you mentioned in
reference 24, 25. How your results showed high prevalence in females?
7. In conclusion: the authors mentioned "The timely detection of viral coinfection could improve
the disease treatment outcomes and enhance the overall survival of the patient", however, in this
study they did not evaluate the treatment outcomes or the survival, so the conclusion is irrelevant
to the aim and methodology of the study.
assistant