Reviewer ’s report  
 
Title:  Therapy susceptible germline -related BRCA 1 -mutation in a case  of metastasized mixed 
adeno -neuroendocrine carcinoma (MANEC) of the small bowel  
 
Version: 0 Date: 20 Nov 2017 
 
Reviewer:  Pavel  Vodicka  
 
Reviewer’s report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supp orting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The manuscript assigned BMGE -D-17-00487 represents potentially interesting case report, 
describ ing pathogenic germline -related BRCA1 mutation and its association with successful cure 
of the patient with adeno -neuroendocrine carcinoma of the small bowel. The case -report is rather 
well documented. However, the manuscript needs to be substantially impr oved prior to the 
acceptance. Additional editorial work and re -phrasing of several parts would further improve the 
manuscript. The title is too lengthy and does not properly advertise the manuscript. Abstract 
should be presented in a more comprehensive way . Conclusions have to be spelled out clearly.  
 
 
Specific comments:  
 
p2, l. 5 -7: the sentence has to be reformulated and made understandable for reader.  
 
p3, l. 2 -3: This is an European study. Is not there any statistics regarding this continent? It may 
be oth erwise than in USA...  
 
p3, l. 15 -17: This part has to be adjusted! Certainly: Microsatellite -instability was present in...  
 
p3, l. 49 on: Please incorporate databases into the running text.  
 
p5, l. 2 on: The first sentence must be re -phrased.  
 
p5, l. 22: What does it mean "Additionally we patient was..."?  
 
p5, l. 27: Please provide explanation on "potential therapeutic molecular alterations".  
 
p5, l. 27 on: Please describe the occurrence of the mutations more plainly.  
 
p5, l. 36: Can one state this, just in case report? Please comment upon.  
p5, l. 50: The sentence has to be reformulated.  
 
p6, l. 4: ...history of a previous malignant tumor.  
 
Are the methods appropria te and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusion s drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose finan cially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hol d or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I do not have any COI.  
 
I agree to the open peer review policy of the journal. I understand that my name wi ll be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available un der an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title:  Therapy susceptible germline -related BRCA 1 -mutation in a case  of metastasized mixed 
adeno -neuroendocrine carcinoma (MANEC) of the small bowel  
 
Version: 0 Date: 20 Nov 2017 
 
Reviewer:  Pavel  Vodicka  
 
Reviewer’s report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supp orting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The manuscript assigned BMGE -D-17-00487 represents potentially interesting case report, 
describ ing pathogenic germline -related BRCA1 mutation and its association with successful cure 
of the patient with adeno -neuroendocrine carcinoma of the small bowel. The case -report is rather 
well documented. However, the manuscript needs to be substantially impr oved prior to the 
acceptance. Additional editorial work and re -phrasing of several parts would further improve the 
manuscript. The title is too lengthy and does not properly advertise the manuscript. Abstract 
should be presented in a more comprehensive way . Conclusions have to be spelled out clearly.  
 
 
Specific comments:  
 
p2, l. 5 -7: the sentence has to be reformulated and made understandable for reader.  
 
p3, l. 2 -3: This is an European study. Is not there any statistics regarding this continent? It may 
be oth erwise than in USA...  
 
p3, l. 15 -17: This part has to be adjusted! Certainly: Microsatellite -instability was present in...  
 
p3, l. 49 on: Please incorporate databases into the running text.  
 
p5, l. 2 on: The first sentence must be re -phrased.  
 
p5, l. 22: What does it mean "Additionally we patient was..."?  
 
p5, l. 27: Please provide explanation on "potential therapeutic molecular alterations".  
 
p5, l. 27 on: Please describe the occurrence of the mutations more plainly.  
 
p5, l. 36: Can one state this, just in case report? Please comment upon.  
p5, l. 50: The sentence has to be reformulated.  
 
p6, l. 4: ...history of a previous malignant tumor.  
 
Are the methods appropria te and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusion s drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose finan cially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hol d or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I do not have any COI.  
 
I agree to the open peer review policy of the journal. I understand that my name wi ll be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available un der an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title:  Therapy susceptible germline -related BRCA 1 -mutation in a case  of metastasized mixed 
adeno -neuroendocrine carcinoma (MANEC) of the small bowel  
 
Version: 0 Date: 20 Nov 2017 
 
Reviewer:  Pavel  Vodicka  
 
Reviewer’s report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versions of manuscripts, graphs, 
supp orting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The manuscript assigned BMGE -D-17-00487 represents potentially interesting case report, 
describ ing pathogenic germline -related BRCA1 mutation and its association with successful cure 
of the patient with adeno -neuroendocrine carcinoma of the small bowel. The case -report is rather 
well documented. However, the manuscript needs to be substantially impr oved prior to the 
acceptance. Additional editorial work and re -phrasing of several parts would further improve the 
manuscript. The title is too lengthy and does not properly advertise the manuscript. Abstract 
should be presented in a more comprehensive way . Conclusions have to be spelled out clearly.  
 
 
Specific comments:  
 
p2, l. 5 -7: the sentence has to be reformulated and made understandable for reader.  
 
p3, l. 2 -3: This is an European study. Is not there any statistics regarding this continent? It may 
be oth erwise than in USA...  
 
p3, l. 15 -17: This part has to be adjusted! Certainly: Microsatellite -instability was present in...  
 
p3, l. 49 on: Please incorporate databases into the running text.  
 
p5, l. 2 on: The first sentence must be re -phrased.  
 
p5, l. 22: What does it mean "Additionally we patient was..."?  
 
p5, l. 27: Please provide explanation on "potential therapeutic molecular alterations".  
 
p5, l. 27 on: Please describe the occurrence of the mutations more plainly.  
 
p5, l. 36: Can one state this, just in case report? Please comment upon.  
p5, l. 50: The sentence has to be reformulated.  
 
p6, l. 4: ...history of a previous malignant tumor.  
 
Are the methods appropria te and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
No 
 
Are the conclusion s drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation that may in any way gain or lose finan cially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hol d or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I do not have any COI.  
 
I agree to the open peer review policy of the journal. I understand that my name wi ll be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available un der an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant