Title: Relationship between Sarcopenia and Minimal Hepatic Encephalopathy in Patients with
Cirrhosis: A Prospective Observational Study
Version: 0 Date: 02 Jan 2025
Reviewer's report:
The current study is an interesting study, and authors explore the association between sarcopenia
and MHE. There are several questions that should be resolved.
1. There were many studies conducted in this questions, authors should indicate the novelty of
the current study.
2. For a prospective study, Did the current study registered on a public website? If so, please
provide the registration number.
3. A Flow Chart of patients’ selection should be provided.
4. Authors excluded the history of decompensation events (e.g., OHE, variceal bleeding,
spontaneous bacterial peritonitis) within the past 3 months, but in table 1, there showed that
approximately 30% of patients had a history of OHE or variceal bleeding. The date frame of
these decompensated events should be provided.
5. For the medications use data, the use of human albumin infusion should be provided, because
of previous evidence showed that it is a potential disease modify agents in patients with liver
cirrhosis and also had a potential benefit for HE.
Title: Relationship between Sarcopenia and Minimal Hepatic Encephalopathy in Patients with
Cirrhosis: A Prospective Observational Study
Version: 0 Date: 02 Jan 2025
Reviewer's report:
The current study is an interesting study, and authors explore the association between sarcopenia
and MHE. There are several questions that should be resolved.
1. There were many studies conducted in this questions, authors should indicate the novelty of
the current study.
2. For a prospective study, Did the current study registered on a public website? If so, please
provide the registration number.
3. A Flow Chart of patients’ selection should be provided.
4. Authors excluded the history of decompensation events (e.g., OHE, variceal bleeding,
spontaneous bacterial peritonitis) within the past 3 months, but in table 1, there showed that
approximately 30% of patients had a history of OHE or variceal bleeding. The date frame of
these decompensated events should be provided.
5. For the medications use data, the use of human albumin infusion should be provided, because
of previous evidence showed that it is a potential disease modify agents in patients with liver
cirrhosis and also had a potential benefit for HE.
Please review this paper.
user
Title: Relationship between Sarcopenia and Minimal Hepatic Encephalopathy in Patients with
Cirrhosis: A Prospective Observational Study
Version: 0 Date: 02 Jan 2025
Reviewer's report:
The current study is an interesting study, and authors explore the association between sarcopenia
and MHE. There are several questions that should be resolved.
1. There were many studies conducted in this questions, authors should indicate the novelty of
the current study.
2. For a prospective study, Did the current study registered on a public website? If so, please
provide the registration number.
3. A Flow Chart of patients’ selection should be provided.
4. Authors excluded the history of decompensation events (e.g., OHE, variceal bleeding,
spontaneous bacterial peritonitis) within the past 3 months, but in table 1, there showed that
approximately 30% of patients had a history of OHE or variceal bleeding. The date frame of
these decompensated events should be provided.
5. For the medications use data, the use of human albumin infusion should be provided, because
of previous evidence showed that it is a potential disease modify agents in patients with liver
cirrhosis and also had a potential benefit for HE.
assistant