Reviewer ’s report  
 
Title:  Celiac Crisis, a rare and profound presentation of Celiac disease: a case report.  
 
Version: 0 Date: 12 Nov 2017 
 
Reviewer:  Muhammed  Mubarak  
 
Reviewer’s report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attach ments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The authors present a case of a 43 -year o ld female with celiac crisis complicating celiac disease. 
The crisis was diagnosed after all other potential causes for various abnormalities were excluded. 
It was treated and the patient showed partial response. It is an interesting case and will illumina te 
the medical fraternity but has some shortcomings, as under:  
 
1. Please give exact values of Iron, Vitamin B12, folate, copper and selenium, rather than 
just stating that these were deficient.  
 
2. Please also give values of BP, rather than just stating tha t patient was hypotensive.  
 
3. Give Marsh classification of the duodenal histopathology.  
 
4. Why nasogastric feeding was done? There is no explanation for this.  
 
5. Mucous in 2nd line of discussion is mucosa.  
 
6. Page 6, line 25, blood work is blood work -up. 
 
7. Follow -up period should be mentioned.  
 
8. Number of references should be increased, at least to 7 -8.  
 
9. In figure 1, bone marrow biopsy is actually bone marrow aspirate. Please rectify it and 
same applies to Figure 2.  
 
10. Give the name of stain and magn ification power for figures 3 and 4.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is rec ommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation  that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relati ng to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
No competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Acc ess Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential  comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title:  Celiac Crisis, a rare and profound presentation of Celiac disease: a case report.  
 
Version: 0 Date: 12 Nov 2017 
 
Reviewer:  Muhammed  Mubarak  
 
Reviewer’s report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attach ments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The authors present a case of a 43 -year o ld female with celiac crisis complicating celiac disease. 
The crisis was diagnosed after all other potential causes for various abnormalities were excluded. 
It was treated and the patient showed partial response. It is an interesting case and will illumina te 
the medical fraternity but has some shortcomings, as under:  
 
1. Please give exact values of Iron, Vitamin B12, folate, copper and selenium, rather than 
just stating that these were deficient.  
 
2. Please also give values of BP, rather than just stating tha t patient was hypotensive.  
 
3. Give Marsh classification of the duodenal histopathology.  
 
4. Why nasogastric feeding was done? There is no explanation for this.  
 
5. Mucous in 2nd line of discussion is mucosa.  
 
6. Page 6, line 25, blood work is blood work -up. 
 
7. Follow -up period should be mentioned.  
 
8. Number of references should be increased, at least to 7 -8.  
 
9. In figure 1, bone marrow biopsy is actually bone marrow aspirate. Please rectify it and 
same applies to Figure 2.  
 
10. Give the name of stain and magn ification power for figures 3 and 4.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is rec ommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation  that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relati ng to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
No competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Acc ess Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential  comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title:  Celiac Crisis, a rare and profound presentation of Celiac disease: a case report.  
 
Version: 0 Date: 12 Nov 2017 
 
Reviewer:  Muhammed  Mubarak  
 
Reviewer’s report:  
 
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attach ments annotated versions of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
 
Please overwrite this text when adding your comments to the authors.  
 
The authors present a case of a 43 -year o ld female with celiac crisis complicating celiac disease. 
The crisis was diagnosed after all other potential causes for various abnormalities were excluded. 
It was treated and the patient showed partial response. It is an interesting case and will illumina te 
the medical fraternity but has some shortcomings, as under:  
 
1. Please give exact values of Iron, Vitamin B12, folate, copper and selenium, rather than 
just stating that these were deficient.  
 
2. Please also give values of BP, rather than just stating tha t patient was hypotensive.  
 
3. Give Marsh classification of the duodenal histopathology.  
 
4. Why nasogastric feeding was done? There is no explanation for this.  
 
5. Mucous in 2nd line of discussion is mucosa.  
 
6. Page 6, line 25, blood work is blood work -up. 
 
7. Follow -up period should be mentioned.  
 
8. Number of references should be increased, at least to 7 -8.  
 
9. In figure 1, bone marrow biopsy is actually bone marrow aspirate. Please rectify it and 
same applies to Figure 2.  
 
10. Give the name of stain and magn ification power for figures 3 and 4.  
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an 
additional statistical review?  
If an additional statistical review is rec ommended, please specify what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an 
organisation  that may in any way gain or lose financially from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relati ng to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the  above, write 'I declare that I have no competing interests' 
below. If your reply is yes to any, please give details below.  
No competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be included 
on my report to the authors and, if the manuscript is accepted for publication, my named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Acc ess Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be included as confidential  comments 
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant