Title: Impact of severe postoperative complications on the prognosis of older patients with
colorectal cancer: A two#center retrospective study
Version: 4 Date: 06 Jan 2024
Reviewer:  Giovanni Tomasicchio
Reviewer's report:
In this retrospective, bi-centre study the authors aimed to investigate the impact of severe
postoperative complications on the oncological outcomes of older and non-older patients with
CRC. The study shows important limitations and there is not particularly novelty in the
results compared to previous studies. However, the authors used the correct methodology and
propensity score matching analysis to control possible cofounders.
I have several questions/comments for the authors:
- In your analysis, you considered only adjuvant chemotherapy, but any patients underwent to
neoadjuvant chemo-radiotherapy for colorectal cancer?
- Moreover, precise if patients were treated in elective or in urgency setting and compare it
between groups.
- In your discussion you need to compare your results with those already present in literature.
Your hypothesis about the post-operative inflammation status of older patients needs more data,
moreover you did not evaluate inflammation post-operative marker in your study.
Title: Impact of severe postoperative complications on the prognosis of older patients with
colorectal cancer: A two#center retrospective study
Version: 4 Date: 06 Jan 2024
Reviewer:  Giovanni Tomasicchio
Reviewer's report:
In this retrospective, bi-centre study the authors aimed to investigate the impact of severe
postoperative complications on the oncological outcomes of older and non-older patients with
CRC. The study shows important limitations and there is not particularly novelty in the
results compared to previous studies. However, the authors used the correct methodology and
propensity score matching analysis to control possible cofounders.
I have several questions/comments for the authors:
- In your analysis, you considered only adjuvant chemotherapy, but any patients underwent to
neoadjuvant chemo-radiotherapy for colorectal cancer?
- Moreover, precise if patients were treated in elective or in urgency setting and compare it
between groups.
- In your discussion you need to compare your results with those already present in literature.
Your hypothesis about the post-operative inflammation status of older patients needs more data,
moreover you did not evaluate inflammation post-operative marker in your study.
Please review this paper.
user
Title: Impact of severe postoperative complications on the prognosis of older patients with
colorectal cancer: A two#center retrospective study
Version: 4 Date: 06 Jan 2024
Reviewer:  Giovanni Tomasicchio
Reviewer's report:
In this retrospective, bi-centre study the authors aimed to investigate the impact of severe
postoperative complications on the oncological outcomes of older and non-older patients with
CRC. The study shows important limitations and there is not particularly novelty in the
results compared to previous studies. However, the authors used the correct methodology and
propensity score matching analysis to control possible cofounders.
I have several questions/comments for the authors:
- In your analysis, you considered only adjuvant chemotherapy, but any patients underwent to
neoadjuvant chemo-radiotherapy for colorectal cancer?
- Moreover, precise if patients were treated in elective or in urgency setting and compare it
between groups.
- In your discussion you need to compare your results with those already present in literature.
Your hypothesis about the post-operative inflammation status of older patients needs more data,
moreover you did not evaluate inflammation post-operative marker in your study.
assistant