Reviewer's report
Title:Afferent signalling from the acid-challenged rat stomach is inhibited and
gastric acid elimination is enhanced by lafutidine
Version: 1Date:23 March 2009
Reviewer: Kenji Okajima
Reviewer's report:
The authors compared the effects of lafutidine and cimetidine on acid-induced
vagal sensory signaling to the brain stem, the gastric mucosal injury, intragastric
acidity and gastric emptying after gastric acid challenge in rats. Acid-induced
vagal afferent signaling was inhibited by these two drugs. However, laftudidne
exerted the gastroprotective effect in pararell with facilitation of gastric emptying
and a reduction of gastric acidity more markedly than cimetidine.The authors
concluded that sensory neuron stimulatory activyt of lafutidine might explain such
a difference observed between these two H2RAs in this animal model.
Major revisions:
Although observations are somewhat interesting, evidence support for the
mechanistic insight the authors made in the paper should be necessary. Major
revisoin providing data supproting the involvement of sensory neurons in
lafutidine-induced events should be done.
Gastric levels of CGRP and prostaglandins (6-keto PGF1a and PGE2) should be
determined after acid and/or drugs. Effect of TRPV 1 antagonists on facilitation of
gastric emptying and a reduction of gastric acidity in animals given these two
drugs.
Minor revisions:
Data obtained in animals given cimetidine should also be described in the
Abstract section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Afferent signalling from the acid-challenged rat stomach is inhibited and
gastric acid elimination is enhanced by lafutidine
Version: 1Date:23 March 2009
Reviewer: Kenji Okajima
Reviewer's report:
The authors compared the effects of lafutidine and cimetidine on acid-induced
vagal sensory signaling to the brain stem, the gastric mucosal injury, intragastric
acidity and gastric emptying after gastric acid challenge in rats. Acid-induced
vagal afferent signaling was inhibited by these two drugs. However, laftudidne
exerted the gastroprotective effect in pararell with facilitation of gastric emptying
and a reduction of gastric acidity more markedly than cimetidine.The authors
concluded that sensory neuron stimulatory activyt of lafutidine might explain such
a difference observed between these two H2RAs in this animal model.
Major revisions:
Although observations are somewhat interesting, evidence support for the
mechanistic insight the authors made in the paper should be necessary. Major
revisoin providing data supproting the involvement of sensory neurons in
lafutidine-induced events should be done.
Gastric levels of CGRP and prostaglandins (6-keto PGF1a and PGE2) should be
determined after acid and/or drugs. Effect of TRPV 1 antagonists on facilitation of
gastric emptying and a reduction of gastric acidity in animals given these two
drugs.
Minor revisions:
Data obtained in animals given cimetidine should also be described in the
Abstract section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Afferent signalling from the acid-challenged rat stomach is inhibited and
gastric acid elimination is enhanced by lafutidine
Version: 1Date:23 March 2009
Reviewer: Kenji Okajima
Reviewer's report:
The authors compared the effects of lafutidine and cimetidine on acid-induced
vagal sensory signaling to the brain stem, the gastric mucosal injury, intragastric
acidity and gastric emptying after gastric acid challenge in rats. Acid-induced
vagal afferent signaling was inhibited by these two drugs. However, laftudidne
exerted the gastroprotective effect in pararell with facilitation of gastric emptying
and a reduction of gastric acidity more markedly than cimetidine.The authors
concluded that sensory neuron stimulatory activyt of lafutidine might explain such
a difference observed between these two H2RAs in this animal model.
Major revisions:
Although observations are somewhat interesting, evidence support for the
mechanistic insight the authors made in the paper should be necessary. Major
revisoin providing data supproting the involvement of sensory neurons in
lafutidine-induced events should be done.
Gastric levels of CGRP and prostaglandins (6-keto PGF1a and PGE2) should be
determined after acid and/or drugs. Effect of TRPV 1 antagonists on facilitation of
gastric emptying and a reduction of gastric acidity in animals given these two
drugs.
Minor revisions:
Data obtained in animals given cimetidine should also be described in the
Abstract section.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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