Reviewer's report
Title:Does the Tokyo Guidelines predict the extent of gallbladder inflammation in
patients with acute cholecystitis? A single center retrospective analysis.
Version:2Date:28 June 2015
Reviewer: David Fuks
Reviewer's report:
Major Compulsory Revisions
1/ the authors should have described the subgroup of patients with Grade I with
either gangrenous or necrotizing cholecystitis (demographics caracteristics,
blood tests and above all intraoperative data such as inflammation of hepatic
ligament or the need of conversion). They should also identify risk factor of
inaccurate evaluation.
2/ even though this information is useful in the present series, indication of early
cholecystectomy in patiens with grade III AC is questionable. The authors should
justify this policy.
Minor Essential Revisions
1/ the relationship between gallbladder inflammation analyzed by the pathologist
and technical difficulty during cholecystectomy is really unclear and should be
slightly discussed.
2/ the different secondary endpoints (including clinical outcomes) should be
analyzed not only according to TG classification but also regarding degree of
inflammation
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Does the Tokyo Guidelines predict the extent of gallbladder inflammation in
patients with acute cholecystitis? A single center retrospective analysis.
Version:2Date:28 June 2015
Reviewer: David Fuks
Reviewer's report:
Major Compulsory Revisions
1/ the authors should have described the subgroup of patients with Grade I with
either gangrenous or necrotizing cholecystitis (demographics caracteristics,
blood tests and above all intraoperative data such as inflammation of hepatic
ligament or the need of conversion). They should also identify risk factor of
inaccurate evaluation.
2/ even though this information is useful in the present series, indication of early
cholecystectomy in patiens with grade III AC is questionable. The authors should
justify this policy.
Minor Essential Revisions
1/ the relationship between gallbladder inflammation analyzed by the pathologist
and technical difficulty during cholecystectomy is really unclear and should be
slightly discussed.
2/ the different secondary endpoints (including clinical outcomes) should be
analyzed not only according to TG classification but also regarding degree of
inflammation
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Does the Tokyo Guidelines predict the extent of gallbladder inflammation in
patients with acute cholecystitis? A single center retrospective analysis.
Version:2Date:28 June 2015
Reviewer: David Fuks
Reviewer's report:
Major Compulsory Revisions
1/ the authors should have described the subgroup of patients with Grade I with
either gangrenous or necrotizing cholecystitis (demographics caracteristics,
blood tests and above all intraoperative data such as inflammation of hepatic
ligament or the need of conversion). They should also identify risk factor of
inaccurate evaluation.
2/ even though this information is useful in the present series, indication of early
cholecystectomy in patiens with grade III AC is questionable. The authors should
justify this policy.
Minor Essential Revisions
1/ the relationship between gallbladder inflammation analyzed by the pathologist
and technical difficulty during cholecystectomy is really unclear and should be
slightly discussed.
2/ the different secondary endpoints (including clinical outcomes) should be
analyzed not only according to TG classification but also regarding degree of
inflammation
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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