Title: Dietary protein intake and mortality among survivors of liver cirrhosis: a prospective
cohort study
Version: 1 Date: 29 Mar 2023
Reviewer's report:
General comments:
The manuscript reports on the effect of dietary protein intake on mortality rates in patients
with liver cirrhosis. The study employed multivariate adjustment and Cox regression models to
calculate the risk ratio (HR) and 95% confidence interval. The results suggest that a higher intake
of total and dairy protein and lower intake of animal protein are associated with a reduced risk
of mortality in cirrhotic patients. The manuscript has some innovative aspects and is significant
in guiding the diet of patients with liver cirrhosis. However, there are several areas where the
manuscript needs improvement.
Specific comments:
1. Survival curve: This article studied the impact of different dietary protein on mortality rate in
patients with liver cirrhosis, with a follow-up time of up to 4 years and 43 deaths during follow-
up. Why was there no survival curve?
2. Models: The authors defined three models to control for potential confounders. However,
most of the significant results were found in Model 3, while Model 1 and Model 2 were not
further mentioned. It would be helpful to analyze and discuss the reasons for this result.
3. Grouping: Participants were grouped into three categories based on tertiles of dietary protein
intake, with T1 as the reference group. However, the basis for this grouping into tertiles was
not explained. Why not compare participants based on the median by dividing them into two
groups? It would be beneficial to explain the rationale behind this grouping
4. Results section: The manuscript needs more detailed explanations of the findings. The study
results are only partially described with statistical differences, and additional information is
needed. Including corresponding chart numbers after the textual description of the research
results would enhance readability.
5. English quality: The English quality of the manuscript needs improvement, with grammar
mistakes requiring correction.For example, on lines 160-161. Please carefully correct the
grammar mistakes.
Title: Dietary protein intake and mortality among survivors of liver cirrhosis: a prospective
cohort study
Version: 1 Date: 29 Mar 2023
Reviewer's report:
General comments:
The manuscript reports on the effect of dietary protein intake on mortality rates in patients
with liver cirrhosis. The study employed multivariate adjustment and Cox regression models to
calculate the risk ratio (HR) and 95% confidence interval. The results suggest that a higher intake
of total and dairy protein and lower intake of animal protein are associated with a reduced risk
of mortality in cirrhotic patients. The manuscript has some innovative aspects and is significant
in guiding the diet of patients with liver cirrhosis. However, there are several areas where the
manuscript needs improvement.
Specific comments:
1. Survival curve: This article studied the impact of different dietary protein on mortality rate in
patients with liver cirrhosis, with a follow-up time of up to 4 years and 43 deaths during follow-
up. Why was there no survival curve?
2. Models: The authors defined three models to control for potential confounders. However,
most of the significant results were found in Model 3, while Model 1 and Model 2 were not
further mentioned. It would be helpful to analyze and discuss the reasons for this result.
3. Grouping: Participants were grouped into three categories based on tertiles of dietary protein
intake, with T1 as the reference group. However, the basis for this grouping into tertiles was
not explained. Why not compare participants based on the median by dividing them into two
groups? It would be beneficial to explain the rationale behind this grouping
4. Results section: The manuscript needs more detailed explanations of the findings. The study
results are only partially described with statistical differences, and additional information is
needed. Including corresponding chart numbers after the textual description of the research
results would enhance readability.
5. English quality: The English quality of the manuscript needs improvement, with grammar
mistakes requiring correction.For example, on lines 160-161. Please carefully correct the
grammar mistakes.
Please review this paper.
user
Title: Dietary protein intake and mortality among survivors of liver cirrhosis: a prospective
cohort study
Version: 1 Date: 29 Mar 2023
Reviewer's report:
General comments:
The manuscript reports on the effect of dietary protein intake on mortality rates in patients
with liver cirrhosis. The study employed multivariate adjustment and Cox regression models to
calculate the risk ratio (HR) and 95% confidence interval. The results suggest that a higher intake
of total and dairy protein and lower intake of animal protein are associated with a reduced risk
of mortality in cirrhotic patients. The manuscript has some innovative aspects and is significant
in guiding the diet of patients with liver cirrhosis. However, there are several areas where the
manuscript needs improvement.
Specific comments:
1. Survival curve: This article studied the impact of different dietary protein on mortality rate in
patients with liver cirrhosis, with a follow-up time of up to 4 years and 43 deaths during follow-
up. Why was there no survival curve?
2. Models: The authors defined three models to control for potential confounders. However,
most of the significant results were found in Model 3, while Model 1 and Model 2 were not
further mentioned. It would be helpful to analyze and discuss the reasons for this result.
3. Grouping: Participants were grouped into three categories based on tertiles of dietary protein
intake, with T1 as the reference group. However, the basis for this grouping into tertiles was
not explained. Why not compare participants based on the median by dividing them into two
groups? It would be beneficial to explain the rationale behind this grouping
4. Results section: The manuscript needs more detailed explanations of the findings. The study
results are only partially described with statistical differences, and additional information is
needed. Including corresponding chart numbers after the textual description of the research
results would enhance readability.
5. English quality: The English quality of the manuscript needs improvement, with grammar
mistakes requiring correction.For example, on lines 160-161. Please carefully correct the
grammar mistakes.
assistant