Reviewer's report
Title:Involvement of a periodontal pathogen, Porphyromonas gingivalis on the
pathogenesis of non-alcoholic fatty liver disease.
Version: 2Date:7 September 2011
Reviewer: Richard Blumberg
Reviewer's report:
Yoneda and colleagues provide a very interesting study wherein they show
increased prevalence of P. gingivalis in patients with NAFLD, that P. gingivalis
worsened NAFLD in rodents and periodontal treatment improved LFTs in NAFLD
patients suggesting a biologically important role of this colonization in humans.
The studies are well-performed, presented and interpreted. It is an important
study. There is only one significant concern that deserves consideration. The
authors need to show that the periodontal treatments affected the quantities of P.
gingivalis in order to conclude that there may be an association in relationship to
the latter finding. In the absence of changes in P. gingivalis, the findings remain
interesting. They should also make sure that the emphasize though the
preliminary nature of the clinical findings but based upon this a randomized
clinical trial is in order to show the clinical benefit as it has important practical
implications for clinical practice.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Involvement of a periodontal pathogen, Porphyromonas gingivalis on the
pathogenesis of non-alcoholic fatty liver disease.
Version: 2Date:7 September 2011
Reviewer: Richard Blumberg
Reviewer's report:
Yoneda and colleagues provide a very interesting study wherein they show
increased prevalence of P. gingivalis in patients with NAFLD, that P. gingivalis
worsened NAFLD in rodents and periodontal treatment improved LFTs in NAFLD
patients suggesting a biologically important role of this colonization in humans.
The studies are well-performed, presented and interpreted. It is an important
study. There is only one significant concern that deserves consideration. The
authors need to show that the periodontal treatments affected the quantities of P.
gingivalis in order to conclude that there may be an association in relationship to
the latter finding. In the absence of changes in P. gingivalis, the findings remain
interesting. They should also make sure that the emphasize though the
preliminary nature of the clinical findings but based upon this a randomized
clinical trial is in order to show the clinical benefit as it has important practical
implications for clinical practice.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Involvement of a periodontal pathogen, Porphyromonas gingivalis on the
pathogenesis of non-alcoholic fatty liver disease.
Version: 2Date:7 September 2011
Reviewer: Richard Blumberg
Reviewer's report:
Yoneda and colleagues provide a very interesting study wherein they show
increased prevalence of P. gingivalis in patients with NAFLD, that P. gingivalis
worsened NAFLD in rodents and periodontal treatment improved LFTs in NAFLD
patients suggesting a biologically important role of this colonization in humans.
The studies are well-performed, presented and interpreted. It is an important
study. There is only one significant concern that deserves consideration. The
authors need to show that the periodontal treatments affected the quantities of P.
gingivalis in order to conclude that there may be an association in relationship to
the latter finding. In the absence of changes in P. gingivalis, the findings remain
interesting. They should also make sure that the emphasize though the
preliminary nature of the clinical findings but based upon this a randomized
clinical trial is in order to show the clinical benefit as it has important practical
implications for clinical practice.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
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