Title: The global, regional, and national burden of appendicitis in 204 countries and territories,
1990–2019: a systematic analysis from the Global Burden of Disease Study 2019 Running title:
the Global Burden of appendicitis 2019
Version: 0 Date: 22 Dec 2022
Reviewer:  David Laith Rawaf
Reviewer's report:
77 - worth expanding on this point? Advancements in technology, approaches, antibiotics,
management criteria, etc.
Diagnosis very difficult without visualisation of appendix. Perhaps future work on diagnostic
tools to avoid surgery would be beneficial.
More emphasis on diagnosis & treatment - namely on utilising education and training
(simulation) to quickly and safely grow the workforce to a standardised level of competency
across all regions. Focus should be on minimally invasive surgery (MIS) in order to reduce
anaesthetic time, injury, hospital stay and complication rates.
Overall good landmark paper.
Title: The global, regional, and national burden of appendicitis in 204 countries and territories,
1990–2019: a systematic analysis from the Global Burden of Disease Study 2019 Running title:
the Global Burden of appendicitis 2019
Version: 0 Date: 22 Dec 2022
Reviewer:  David Laith Rawaf
Reviewer's report:
77 - worth expanding on this point? Advancements in technology, approaches, antibiotics,
management criteria, etc.
Diagnosis very difficult without visualisation of appendix. Perhaps future work on diagnostic
tools to avoid surgery would be beneficial.
More emphasis on diagnosis & treatment - namely on utilising education and training
(simulation) to quickly and safely grow the workforce to a standardised level of competency
across all regions. Focus should be on minimally invasive surgery (MIS) in order to reduce
anaesthetic time, injury, hospital stay and complication rates.
Overall good landmark paper.
Please review this paper.
user
Title: The global, regional, and national burden of appendicitis in 204 countries and territories,
1990–2019: a systematic analysis from the Global Burden of Disease Study 2019 Running title:
the Global Burden of appendicitis 2019
Version: 0 Date: 22 Dec 2022
Reviewer:  David Laith Rawaf
Reviewer's report:
77 - worth expanding on this point? Advancements in technology, approaches, antibiotics,
management criteria, etc.
Diagnosis very difficult without visualisation of appendix. Perhaps future work on diagnostic
tools to avoid surgery would be beneficial.
More emphasis on diagnosis & treatment - namely on utilising education and training
(simulation) to quickly and safely grow the workforce to a standardised level of competency
across all regions. Focus should be on minimally invasive surgery (MIS) in order to reduce
anaesthetic time, injury, hospital stay and complication rates.
Overall good landmark paper.
assistant