Reviewer's report 
 Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced fasted motor Title: 
activity of the colon in conscious fed rats. 
 1  27 October 2004 Version: Date: 
 Theo Peeters Reviewer: 
Reviewer's report: 
General 
Interesting piece of work. Although the findings could have been explored in more detail they deserve publication. 
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Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
Background. Omit reference 10 at line 13. 
Results. Figures 1 and 2 are interchanged. Vertical axis legends overlap with labels. Horizontal axis 
labesl fo figure 1 should be doses instead of A,B,C etc.. Abbreviation MI is not in general list and it 
took me a while to realize it was micro-injection and is explained in the legend. Actually it is 
superfluous. Drop MI. 
Tables give the same data as the figures. Drop the Tables. 
Discussion. "....as well as NPY antiserum [10]." Should be [11]. 
Put always periods after brackets of reference numbers. 
I think the data, as well as other studies, suggest that ghrelin acts on NPY neurons. It is therefore in 
my opinion not corret to say that "...ghrelin unfolds.. by acting on central NPY1 but NPY2 rceptors". Besides the word NOT is missing here. This kind of confusing is repeated a few times in the 
discussion. See also the paragraph Conclusions for example. 
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Discretionary Revisions (which the author can choose to ignore) 
 Accept after minor essential revisions What next?: 
 An article of importance in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
None 
Reviewer's report 
 Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced fasted motor Title: 
activity of the colon in conscious fed rats. 
 1  27 October 2004 Version: Date: 
 Theo Peeters Reviewer: 
Reviewer's report: 
General 
Interesting piece of work. Although the findings could have been explored in more detail they deserve publication. 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
Background. Omit reference 10 at line 13. 
Results. Figures 1 and 2 are interchanged. Vertical axis legends overlap with labels. Horizontal axis 
labesl fo figure 1 should be doses instead of A,B,C etc.. Abbreviation MI is not in general list and it 
took me a while to realize it was micro-injection and is explained in the legend. Actually it is 
superfluous. Drop MI. 
Tables give the same data as the figures. Drop the Tables. 
Discussion. "....as well as NPY antiserum [10]." Should be [11]. 
Put always periods after brackets of reference numbers. 
I think the data, as well as other studies, suggest that ghrelin acts on NPY neurons. It is therefore in 
my opinion not corret to say that "...ghrelin unfolds.. by acting on central NPY1 but NPY2 rceptors". Besides the word NOT is missing here. This kind of confusing is repeated a few times in the 
discussion. See also the paragraph Conclusions for example. 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
 Accept after minor essential revisions What next?: 
 An article of importance in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
None 
Please review this paper.
user
Reviewer's report 
 Central neuropeptide Y receptors are involved in 3rd ventricular ghrelin induced fasted motor Title: 
activity of the colon in conscious fed rats. 
 1  27 October 2004 Version: Date: 
 Theo Peeters Reviewer: 
Reviewer's report: 
General 
Interesting piece of work. Although the findings could have been explored in more detail they deserve publication. 
------------------------------------------------------------------------------- 
Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
Background. Omit reference 10 at line 13. 
Results. Figures 1 and 2 are interchanged. Vertical axis legends overlap with labels. Horizontal axis 
labesl fo figure 1 should be doses instead of A,B,C etc.. Abbreviation MI is not in general list and it 
took me a while to realize it was micro-injection and is explained in the legend. Actually it is 
superfluous. Drop MI. 
Tables give the same data as the figures. Drop the Tables. 
Discussion. "....as well as NPY antiserum [10]." Should be [11]. 
Put always periods after brackets of reference numbers. 
I think the data, as well as other studies, suggest that ghrelin acts on NPY neurons. It is therefore in 
my opinion not corret to say that "...ghrelin unfolds.. by acting on central NPY1 but NPY2 rceptors". Besides the word NOT is missing here. This kind of confusing is repeated a few times in the 
discussion. See also the paragraph Conclusions for example. 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
 Accept after minor essential revisions What next?: 
 An article of importance in its field Level of interest: 
 Acceptable Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
None 
assistant