Reviewer's report
Title:Abnormal Fecal Microbiota Community and Functions in Patients with
Hepatitis B Liver Cirrhosis as Revealed by a Metagenomic Approach
Version:1Date:23 October 2013
Reviewer: Isabella Inden
Reviewer's report:
Major Compulsory Revsisions:
1. How many HBV-DNA copies have the patients in the different CTP-grading
groups? Is there a correlation between viral load and microbiota
community/functions?
2. Is there a difference in microbiota community and functions between
HBV-treated patients/non-treated patients and resolver?
3. Is the control cohort also Anti-HBc negativ or only HBV-DNA negative?
Minor Essential revisions:
1. Some spelling mistakes, for exampel "negtive" in Table 1, or "possessd" in
DISCUSSION.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Abnormal Fecal Microbiota Community and Functions in Patients with
Hepatitis B Liver Cirrhosis as Revealed by a Metagenomic Approach
Version:1Date:23 October 2013
Reviewer: Isabella Inden
Reviewer's report:
Major Compulsory Revsisions:
1. How many HBV-DNA copies have the patients in the different CTP-grading
groups? Is there a correlation between viral load and microbiota
community/functions?
2. Is there a difference in microbiota community and functions between
HBV-treated patients/non-treated patients and resolver?
3. Is the control cohort also Anti-HBc negativ or only HBV-DNA negative?
Minor Essential revisions:
1. Some spelling mistakes, for exampel "negtive" in Table 1, or "possessd" in
DISCUSSION.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Abnormal Fecal Microbiota Community and Functions in Patients with
Hepatitis B Liver Cirrhosis as Revealed by a Metagenomic Approach
Version:1Date:23 October 2013
Reviewer: Isabella Inden
Reviewer's report:
Major Compulsory Revsisions:
1. How many HBV-DNA copies have the patients in the different CTP-grading
groups? Is there a correlation between viral load and microbiota
community/functions?
2. Is there a difference in microbiota community and functions between
HBV-treated patients/non-treated patients and resolver?
3. Is the control cohort also Anti-HBc negativ or only HBV-DNA negative?
Minor Essential revisions:
1. Some spelling mistakes, for exampel "negtive" in Table 1, or "possessd" in
DISCUSSION.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant