Title: A nomogram based on CT texture features to predict the response of patients with
advanced pancreatic cancer treated with chemotherapy
Version: 1 Date: 04 Jun 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: - The topic of this study is very interesting. It is well known that the
understanding of a response to chemotherapy is of primary importance. And this is very true in
pancreatic cancer, which can be associated to poor rensponse to drugs
- The authors designed a very detailed study to understant if CT scan can be used to predict and
monitor the chemo response
- Reading "methods" and "results" it is not easy to understand what can be the real clinical
application. It is appreciable that all the process is described in technical details. However
eventually it should be better explained how clinicians can use CT scan for their patients. This
should happen also in the "discussion" section
- It is not clear why they created two groups (training and validation), and how they decided the
number of patients for each group
REQUESTED REVISIONS:
- They should explain how they divided the patients in the two groups and how they identified
the numbers
- The authors should discuss more about the clinical application of such techniques, simplifying
the complex results
ADDITIONAL REQUESTS/SUGGESTIONS:
As stated above
Title: A nomogram based on CT texture features to predict the response of patients with
advanced pancreatic cancer treated with chemotherapy
Version: 1 Date: 04 Jun 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: - The topic of this study is very interesting. It is well known that the
understanding of a response to chemotherapy is of primary importance. And this is very true in
pancreatic cancer, which can be associated to poor rensponse to drugs
- The authors designed a very detailed study to understant if CT scan can be used to predict and
monitor the chemo response
- Reading "methods" and "results" it is not easy to understand what can be the real clinical
application. It is appreciable that all the process is described in technical details. However
eventually it should be better explained how clinicians can use CT scan for their patients. This
should happen also in the "discussion" section
- It is not clear why they created two groups (training and validation), and how they decided the
number of patients for each group
REQUESTED REVISIONS:
- They should explain how they divided the patients in the two groups and how they identified
the numbers
- The authors should discuss more about the clinical application of such techniques, simplifying
the complex results
ADDITIONAL REQUESTS/SUGGESTIONS:
As stated above
Please review this paper.
user
Title: A nomogram based on CT texture features to predict the response of patients with
advanced pancreatic cancer treated with chemotherapy
Version: 1 Date: 04 Jun 2023
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
No - there are minor issues
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: - The topic of this study is very interesting. It is well known that the
understanding of a response to chemotherapy is of primary importance. And this is very true in
pancreatic cancer, which can be associated to poor rensponse to drugs
- The authors designed a very detailed study to understant if CT scan can be used to predict and
monitor the chemo response
- Reading "methods" and "results" it is not easy to understand what can be the real clinical
application. It is appreciable that all the process is described in technical details. However
eventually it should be better explained how clinicians can use CT scan for their patients. This
should happen also in the "discussion" section
- It is not clear why they created two groups (training and validation), and how they decided the
number of patients for each group
REQUESTED REVISIONS:
- They should explain how they divided the patients in the two groups and how they identified
the numbers
- The authors should discuss more about the clinical application of such techniques, simplifying
the complex results
ADDITIONAL REQUESTS/SUGGESTIONS:
As stated above
assistant