Title: Transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic
pathways in mice
Version: 1 Date: 01 Mar 2021
Reviewer's report:
In this study, the authors aim to investigate the role and mechanism of a high salt diet in liver
function. They claimed that a high-salt diet could induce a serious abnormal liver metabolic
pathway in mice, although substantial damage has not yet been shown. This study is the first to
reveal the impact of a high-salt diet on the liver at the omics level and provides theoretical support
for potential clinical risk evaluation, pathogenic mechanisms, and drug design for combating
liver dysfunction, and this study also provides a serious candidate direction for further research
on the physiological impacts of high-salt diets. However, this study lack of clear endpoint, and
the mechanism can not support their conclusion.
Title: Transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic
pathways in mice
Version: 1 Date: 01 Mar 2021
Reviewer's report:
In this study, the authors aim to investigate the role and mechanism of a high salt diet in liver
function. They claimed that a high-salt diet could induce a serious abnormal liver metabolic
pathway in mice, although substantial damage has not yet been shown. This study is the first to
reveal the impact of a high-salt diet on the liver at the omics level and provides theoretical support
for potential clinical risk evaluation, pathogenic mechanisms, and drug design for combating
liver dysfunction, and this study also provides a serious candidate direction for further research
on the physiological impacts of high-salt diets. However, this study lack of clear endpoint, and
the mechanism can not support their conclusion.
Please review this paper.
user
Title: Transcriptome sequencing reveals high-salt diet-induced abnormal liver metabolic
pathways in mice
Version: 1 Date: 01 Mar 2021
Reviewer's report:
In this study, the authors aim to investigate the role and mechanism of a high salt diet in liver
function. They claimed that a high-salt diet could induce a serious abnormal liver metabolic
pathway in mice, although substantial damage has not yet been shown. This study is the first to
reveal the impact of a high-salt diet on the liver at the omics level and provides theoretical support
for potential clinical risk evaluation, pathogenic mechanisms, and drug design for combating
liver dysfunction, and this study also provides a serious candidate direction for further research
on the physiological impacts of high-salt diets. However, this study lack of clear endpoint, and
the mechanism can not support their conclusion.
assistant