Title: Impact of Occupation on Survival of Esophageal Squamous Cell Carcinoma Patients
Following Esophagectomy : A Long-term Survival Analysis
Version: 2 Date: 17 Mar 2025
Reviewer's report:
This is a longitudinal study aimed to  explore the long-term overall survival (OS) of patients with
differing occupational backgrounds who undergo esophagectomy. The findings are interesting.
However, I had some concerns for this study.
1-The relevant review or meta analysis should be added in the introduction section.
2-Which package was adopted in R for statistical analysis? The authors should clarify this
concern.
3-Statistical analysis is well written. Does univariate analysis show significance among
important variables?
4-The sample size is large. But, I still suggest the authors should clarify the normal assumption
for variables in this study.
5-Subgroup analysis of various work groups is usually used to identify interaction effects. Does
any interaction effect show significance among subgroup variables?
6-Please add RCS of hazard ratio (HR). I mean the clinical merit of nodes of RCS for HR should
be discussed.
7-Please add DCA analysis in this study.
8-Please check the typos before re-submission.
Title: Impact of Occupation on Survival of Esophageal Squamous Cell Carcinoma Patients
Following Esophagectomy : A Long-term Survival Analysis
Version: 2 Date: 17 Mar 2025
Reviewer's report:
This is a longitudinal study aimed to  explore the long-term overall survival (OS) of patients with
differing occupational backgrounds who undergo esophagectomy. The findings are interesting.
However, I had some concerns for this study.
1-The relevant review or meta analysis should be added in the introduction section.
2-Which package was adopted in R for statistical analysis? The authors should clarify this
concern.
3-Statistical analysis is well written. Does univariate analysis show significance among
important variables?
4-The sample size is large. But, I still suggest the authors should clarify the normal assumption
for variables in this study.
5-Subgroup analysis of various work groups is usually used to identify interaction effects. Does
any interaction effect show significance among subgroup variables?
6-Please add RCS of hazard ratio (HR). I mean the clinical merit of nodes of RCS for HR should
be discussed.
7-Please add DCA analysis in this study.
8-Please check the typos before re-submission.
Please review this paper.
user
Title: Impact of Occupation on Survival of Esophageal Squamous Cell Carcinoma Patients
Following Esophagectomy : A Long-term Survival Analysis
Version: 2 Date: 17 Mar 2025
Reviewer's report:
This is a longitudinal study aimed to  explore the long-term overall survival (OS) of patients with
differing occupational backgrounds who undergo esophagectomy. The findings are interesting.
However, I had some concerns for this study.
1-The relevant review or meta analysis should be added in the introduction section.
2-Which package was adopted in R for statistical analysis? The authors should clarify this
concern.
3-Statistical analysis is well written. Does univariate analysis show significance among
important variables?
4-The sample size is large. But, I still suggest the authors should clarify the normal assumption
for variables in this study.
5-Subgroup analysis of various work groups is usually used to identify interaction effects. Does
any interaction effect show significance among subgroup variables?
6-Please add RCS of hazard ratio (HR). I mean the clinical merit of nodes of RCS for HR should
be discussed.
7-Please add DCA analysis in this study.
8-Please check the typos before re-submission.
assistant