Title: Establishment and evaluation of a prediction model for acute gastrointestinal injury in
patients with prolonged disorder of consciousness
Version: 2 Date: 05 Jul 2022
Reviewer's report:
The authors established a prediction model for acute gastrointestinal injury in prolonged
disorder of consciousness which included 165 patients. It is well written and has the potential
to accurately predict the incidence of AGI in pDOC patients. I have several comments for
improvement.
Major
#How were the covariates for multivariate regression analysis selected? This should be explicitly
stated.
#Result: Is there some information about the causative disease of pDOC such as TBI, stroke,
neurosurgery, etc?
#Although the definition and diagnostic criteria of AGI is stated in the method section, I could
not find AGI grade of the included patients. High grade of AGI should be clinically important,
and thus that should be stated in results. If the grade of AGI is available, is there any association
between the present prediction model and the grade of AGI ?
#More patients received broad-spectrum antibiotics in AGI group than in N-AGI group, which
could increase acute gastrointestinal injury such as diarrhea. Did you adjust this factor?
#This prediction model showed high accuracy to predict the incidence of AGI patients. Please
state the usefulness of the model in clinical settings in the discussion. If the score is high and
has potential to develop AGI, what treatment or intervention will be considered?
Minor
#Method:
“After exclusion according to the exclusion criteria, a total of 165 patients were included.” in
clinical data on material and methods – this sentence should be stated in the results section.
#Most patients with pDOC receive antiulcer agents. Was the information collected in the study?
Title: Establishment and evaluation of a prediction model for acute gastrointestinal injury in
patients with prolonged disorder of consciousness
Version: 2 Date: 05 Jul 2022
Reviewer's report:
The authors established a prediction model for acute gastrointestinal injury in prolonged
disorder of consciousness which included 165 patients. It is well written and has the potential
to accurately predict the incidence of AGI in pDOC patients. I have several comments for
improvement.
Major
#How were the covariates for multivariate regression analysis selected? This should be explicitly
stated.
#Result: Is there some information about the causative disease of pDOC such as TBI, stroke,
neurosurgery, etc?
#Although the definition and diagnostic criteria of AGI is stated in the method section, I could
not find AGI grade of the included patients. High grade of AGI should be clinically important,
and thus that should be stated in results. If the grade of AGI is available, is there any association
between the present prediction model and the grade of AGI ?
#More patients received broad-spectrum antibiotics in AGI group than in N-AGI group, which
could increase acute gastrointestinal injury such as diarrhea. Did you adjust this factor?
#This prediction model showed high accuracy to predict the incidence of AGI patients. Please
state the usefulness of the model in clinical settings in the discussion. If the score is high and
has potential to develop AGI, what treatment or intervention will be considered?
Minor
#Method:
“After exclusion according to the exclusion criteria, a total of 165 patients were included.” in
clinical data on material and methods – this sentence should be stated in the results section.
#Most patients with pDOC receive antiulcer agents. Was the information collected in the study?
Please review this paper.
user
Title: Establishment and evaluation of a prediction model for acute gastrointestinal injury in
patients with prolonged disorder of consciousness
Version: 2 Date: 05 Jul 2022
Reviewer's report:
The authors established a prediction model for acute gastrointestinal injury in prolonged
disorder of consciousness which included 165 patients. It is well written and has the potential
to accurately predict the incidence of AGI in pDOC patients. I have several comments for
improvement.
Major
#How were the covariates for multivariate regression analysis selected? This should be explicitly
stated.
#Result: Is there some information about the causative disease of pDOC such as TBI, stroke,
neurosurgery, etc?
#Although the definition and diagnostic criteria of AGI is stated in the method section, I could
not find AGI grade of the included patients. High grade of AGI should be clinically important,
and thus that should be stated in results. If the grade of AGI is available, is there any association
between the present prediction model and the grade of AGI ?
#More patients received broad-spectrum antibiotics in AGI group than in N-AGI group, which
could increase acute gastrointestinal injury such as diarrhea. Did you adjust this factor?
#This prediction model showed high accuracy to predict the incidence of AGI patients. Please
state the usefulness of the model in clinical settings in the discussion. If the score is high and
has potential to develop AGI, what treatment or intervention will be considered?
Minor
#Method:
“After exclusion according to the exclusion criteria, a total of 165 patients were included.” in
clinical data on material and methods – this sentence should be stated in the results section.
#Most patients with pDOC receive antiulcer agents. Was the information collected in the study?
assistant