Reviewer's report
Title:Hepatobiliary cystadenocarcinoma without mesenchymal stroma in a
female patient: a case report
Version:1Date:7 March 2014
Reviewer: omar shah
Reviewer's report:
Major compulsory
The differentiation of biliary cystadenocarcinomas from IMPN-B and intrahepatic
cholangiocarcinoma is a pathologist’s nightmare, with many pathologists
reluctant for giving a diagnosis of cystadenocarcinoma when OS is missing;
a) Did you use any IHC staining for mucins and ck-7/20.
b) How many samples of the specimen were analysed, as in some patients OS
may be focally present.
The article needs more CT pictographs with vivid delineation of the lesion and
the surrounding liver architecture and a IHC picture if done.
The USG picture quality is not so good.
Some intrao-operative photographs and the pictures when grossing the
specimen would be more than handful.
Minor Essential Revision
Your article has some grammatical corrections amidst the colloquialism of
language.
The exclusivity of ovarian stroma and female sex as regarding
cystadenocarcinomas is not a rule thou much more common.(Bardin et al, 2004).
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Reviewer's report
Title:Hepatobiliary cystadenocarcinoma without mesenchymal stroma in a
female patient: a case report
Version:1Date:7 March 2014
Reviewer: omar shah
Reviewer's report:
Major compulsory
The differentiation of biliary cystadenocarcinomas from IMPN-B and intrahepatic
cholangiocarcinoma is a pathologist’s nightmare, with many pathologists
reluctant for giving a diagnosis of cystadenocarcinoma when OS is missing;
a) Did you use any IHC staining for mucins and ck-7/20.
b) How many samples of the specimen were analysed, as in some patients OS
may be focally present.
The article needs more CT pictographs with vivid delineation of the lesion and
the surrounding liver architecture and a IHC picture if done.
The USG picture quality is not so good.
Some intrao-operative photographs and the pictures when grossing the
specimen would be more than handful.
Minor Essential Revision
Your article has some grammatical corrections amidst the colloquialism of
language.
The exclusivity of ovarian stroma and female sex as regarding
cystadenocarcinomas is not a rule thou much more common.(Bardin et al, 2004).
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Please review this paper.
user
Reviewer's report
Title:Hepatobiliary cystadenocarcinoma without mesenchymal stroma in a
female patient: a case report
Version:1Date:7 March 2014
Reviewer: omar shah
Reviewer's report:
Major compulsory
The differentiation of biliary cystadenocarcinomas from IMPN-B and intrahepatic
cholangiocarcinoma is a pathologist’s nightmare, with many pathologists
reluctant for giving a diagnosis of cystadenocarcinoma when OS is missing;
a) Did you use any IHC staining for mucins and ck-7/20.
b) How many samples of the specimen were analysed, as in some patients OS
may be focally present.
The article needs more CT pictographs with vivid delineation of the lesion and
the surrounding liver architecture and a IHC picture if done.
The USG picture quality is not so good.
Some intrao-operative photographs and the pictures when grossing the
specimen would be more than handful.
Minor Essential Revision
Your article has some grammatical corrections amidst the colloquialism of
language.
The exclusivity of ovarian stroma and female sex as regarding
cystadenocarcinomas is not a rule thou much more common.(Bardin et al, 2004).
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
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