Title: Impact of atherosclerosis on the postoperative complications of colorectal surgery in older
patients with colorectal cancer
Version: 1 Date: 16 Oct 2022
Reviewer's report:
Authors showed the impact of artherosclerosis of the elderly on the postoperative complications
of colorectal surgery by evaluating two biomarkers, CAVI and AAC score. The aim and
conclusions are clear and informative but  the manuscript itself has several major points to be
revised.
1. Some data are statistically incorrect. "Univariate analysis" in Table 2 seems like a result of chi-
square's test. I think these data should be shown as an independent table. In addition, regarding
"logistic regression" in Table 2, is this analysis performed as univariate analysis or multivariate
analysis? Even if there are factors that did not show significance, odds ratio and 95% CI should
be shown.
2. Although the authors are discussing about the types of complications ( Line236-), predicted
underlying mechanism is still unclear. There are some description regarding paralytic ileus, but
how about the infectious complications? Is there any evidence from the aspect of immune system
regarding  artherosclerosis? The sentence from Line242, "...indicating that our result was not a
coincidence", is unclear. Authors  should clarify what you are trying to explain scientifically.
3. Were there any patients who created diverting stoma in anterior resection to avoid anastomotic
leakage? Do you think we should use CAVI/AAC for the decision of creating diverting stoma?
4. Related to the previous comment, authors should discuss about how we can utilize CAVI/
AAC into clinics. What kind of behavior change is expected by measuring these?
Title: Impact of atherosclerosis on the postoperative complications of colorectal surgery in older
patients with colorectal cancer
Version: 1 Date: 16 Oct 2022
Reviewer's report:
Authors showed the impact of artherosclerosis of the elderly on the postoperative complications
of colorectal surgery by evaluating two biomarkers, CAVI and AAC score. The aim and
conclusions are clear and informative but  the manuscript itself has several major points to be
revised.
1. Some data are statistically incorrect. "Univariate analysis" in Table 2 seems like a result of chi-
square's test. I think these data should be shown as an independent table. In addition, regarding
"logistic regression" in Table 2, is this analysis performed as univariate analysis or multivariate
analysis? Even if there are factors that did not show significance, odds ratio and 95% CI should
be shown.
2. Although the authors are discussing about the types of complications ( Line236-), predicted
underlying mechanism is still unclear. There are some description regarding paralytic ileus, but
how about the infectious complications? Is there any evidence from the aspect of immune system
regarding  artherosclerosis? The sentence from Line242, "...indicating that our result was not a
coincidence", is unclear. Authors  should clarify what you are trying to explain scientifically.
3. Were there any patients who created diverting stoma in anterior resection to avoid anastomotic
leakage? Do you think we should use CAVI/AAC for the decision of creating diverting stoma?
4. Related to the previous comment, authors should discuss about how we can utilize CAVI/
AAC into clinics. What kind of behavior change is expected by measuring these?
Please review this paper.
user
Title: Impact of atherosclerosis on the postoperative complications of colorectal surgery in older
patients with colorectal cancer
Version: 1 Date: 16 Oct 2022
Reviewer's report:
Authors showed the impact of artherosclerosis of the elderly on the postoperative complications
of colorectal surgery by evaluating two biomarkers, CAVI and AAC score. The aim and
conclusions are clear and informative but  the manuscript itself has several major points to be
revised.
1. Some data are statistically incorrect. "Univariate analysis" in Table 2 seems like a result of chi-
square's test. I think these data should be shown as an independent table. In addition, regarding
"logistic regression" in Table 2, is this analysis performed as univariate analysis or multivariate
analysis? Even if there are factors that did not show significance, odds ratio and 95% CI should
be shown.
2. Although the authors are discussing about the types of complications ( Line236-), predicted
underlying mechanism is still unclear. There are some description regarding paralytic ileus, but
how about the infectious complications? Is there any evidence from the aspect of immune system
regarding  artherosclerosis? The sentence from Line242, "...indicating that our result was not a
coincidence", is unclear. Authors  should clarify what you are trying to explain scientifically.
3. Were there any patients who created diverting stoma in anterior resection to avoid anastomotic
leakage? Do you think we should use CAVI/AAC for the decision of creating diverting stoma?
4. Related to the previous comment, authors should discuss about how we can utilize CAVI/
AAC into clinics. What kind of behavior change is expected by measuring these?
assistant