Title: Efficacy of endoscopic gastrojejunal bypass in obese Yucatan pigs: a comparative animal
study
Version: 1 Date: 20 Mar 2023
Reviewer's report:
The authors showed the interesting results about a less invasive alternative to surgical gastric
bypass for obesity.
I have few comments.
1. In Fig3b, authors showed the picture meaning "Same picture magnification and showing mild
acute inflammatory changes in the central anastomotic areas."
I would like to see the picture of inflammatory lesions in high-power field and know how many
months after surgery was the autopsy performed.
If the inflammation occurring in the lesion was chronic or subacute, it could be  understandable
as surgical healing process. However, if it was acute, there might be other causes, such as blood
flow abnormalities after bypass or hyper-pressure on the GJA and so on.
2. I felt it was disappointing that many of the endocrine and metabolic studies have not been
performed. Since the number of experimental animals was small, I think it would be better to
show the data of each individual as a supplementary table.
Title: Efficacy of endoscopic gastrojejunal bypass in obese Yucatan pigs: a comparative animal
study
Version: 1 Date: 20 Mar 2023
Reviewer's report:
The authors showed the interesting results about a less invasive alternative to surgical gastric
bypass for obesity.
I have few comments.
1. In Fig3b, authors showed the picture meaning "Same picture magnification and showing mild
acute inflammatory changes in the central anastomotic areas."
I would like to see the picture of inflammatory lesions in high-power field and know how many
months after surgery was the autopsy performed.
If the inflammation occurring in the lesion was chronic or subacute, it could be  understandable
as surgical healing process. However, if it was acute, there might be other causes, such as blood
flow abnormalities after bypass or hyper-pressure on the GJA and so on.
2. I felt it was disappointing that many of the endocrine and metabolic studies have not been
performed. Since the number of experimental animals was small, I think it would be better to
show the data of each individual as a supplementary table.
Please review this paper.
user
Title: Efficacy of endoscopic gastrojejunal bypass in obese Yucatan pigs: a comparative animal
study
Version: 1 Date: 20 Mar 2023
Reviewer's report:
The authors showed the interesting results about a less invasive alternative to surgical gastric
bypass for obesity.
I have few comments.
1. In Fig3b, authors showed the picture meaning "Same picture magnification and showing mild
acute inflammatory changes in the central anastomotic areas."
I would like to see the picture of inflammatory lesions in high-power field and know how many
months after surgery was the autopsy performed.
If the inflammation occurring in the lesion was chronic or subacute, it could be  understandable
as surgical healing process. However, if it was acute, there might be other causes, such as blood
flow abnormalities after bypass or hyper-pressure on the GJA and so on.
2. I felt it was disappointing that many of the endocrine and metabolic studies have not been
performed. Since the number of experimental animals was small, I think it would be better to
show the data of each individual as a supplementary table.
assistant