Reviewer's report
Title:Synchronous mucosal Schwann-cell hamartomas in a young adult as a
possible mucosal Schwann-cell harmatomatosis: a case report
Version:4Date:11 March 2015
Reviewer: stephen M lagana
Reviewer's report:
1. Major issues
There are no huge issues with this paper. I would classify this as somewhat
interesting, but very rare. The issues I would address are as follows:
Although you state that this is the first case diagnosed <30yrs of age, it is well to
remember that these are asymptomatic and discovered generally at screening
colonoscopy and 30yr olds do not get screening colonoscopy. Therefore,
although it may be factually correct that this is the first, a statement mentioning
this consideration is warranted.
2. Minor essential revisions: Page 6 Line 18 has a typo. "hamartomas" not
"hamartoms"
3. Discretionary items:
It would be nice to know if there were any PTEN mutations, since Cowden's
Syndrome comes to mind. Can this be done? Perhaps there's an NGS platform
available that can be applied?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Synchronous mucosal Schwann-cell hamartomas in a young adult as a
possible mucosal Schwann-cell harmatomatosis: a case report
Version:4Date:11 March 2015
Reviewer: stephen M lagana
Reviewer's report:
1. Major issues
There are no huge issues with this paper. I would classify this as somewhat
interesting, but very rare. The issues I would address are as follows:
Although you state that this is the first case diagnosed <30yrs of age, it is well to
remember that these are asymptomatic and discovered generally at screening
colonoscopy and 30yr olds do not get screening colonoscopy. Therefore,
although it may be factually correct that this is the first, a statement mentioning
this consideration is warranted.
2. Minor essential revisions: Page 6 Line 18 has a typo. "hamartomas" not
"hamartoms"
3. Discretionary items:
It would be nice to know if there were any PTEN mutations, since Cowden's
Syndrome comes to mind. Can this be done? Perhaps there's an NGS platform
available that can be applied?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Synchronous mucosal Schwann-cell hamartomas in a young adult as a
possible mucosal Schwann-cell harmatomatosis: a case report
Version:4Date:11 March 2015
Reviewer: stephen M lagana
Reviewer's report:
1. Major issues
There are no huge issues with this paper. I would classify this as somewhat
interesting, but very rare. The issues I would address are as follows:
Although you state that this is the first case diagnosed <30yrs of age, it is well to
remember that these are asymptomatic and discovered generally at screening
colonoscopy and 30yr olds do not get screening colonoscopy. Therefore,
although it may be factually correct that this is the first, a statement mentioning
this consideration is warranted.
2. Minor essential revisions: Page 6 Line 18 has a typo. "hamartomas" not
"hamartoms"
3. Discretionary items:
It would be nice to know if there were any PTEN mutations, since Cowden's
Syndrome comes to mind. Can this be done? Perhaps there's an NGS platform
available that can be applied?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant