Reviewer's report
Title:In vivo and ex vivo effects of propofol on myocardial performance in rats
with obstructive jaundice
Version: 6Date:23 June 2011
Reviewer: renyu liu
Reviewer's report:
Comments:
The authors extensively investigated the effects of propofol on myocardial
performance in both in vivo and in vitro. They found that there is no significant
effect on cardiac contractility from low or intermediate dose of propofol in
obstructive jaundice with normal cardiac function. However, 0.9 mg/kg/min of
propofol produce significantly greater cardiac depression in jaundiced rat. Similar
finding is observed ex-vivo experiment.
The experiments are well designed and the findings are interesting and
reasonable.
Major Concerns about this paper
1. The authors should seek help for professional English editing before
considering re-submit it again
2. The authors should put more effort to discuss the clinical significance for their
findings. The conclusion should be modified to define well what they have
investigated. For example: propofol appears to be a safe alternative anesthetics
agent in patients with obstructive jaundice and normal cardiac function at low and
intermediate doses.
Minor issues:
1. Why only male rats were chosen. Does sex hormone plays any role?
2. Table 1 can be omitted by simply describing them in the text.
3. Is there any potential correlation between level of TBIL or ALT and effects of
propofol?
Level of interest: An article of importance in its field
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:In vivo and ex vivo effects of propofol on myocardial performance in rats
with obstructive jaundice
Version: 6Date:23 June 2011
Reviewer: renyu liu
Reviewer's report:
Comments:
The authors extensively investigated the effects of propofol on myocardial
performance in both in vivo and in vitro. They found that there is no significant
effect on cardiac contractility from low or intermediate dose of propofol in
obstructive jaundice with normal cardiac function. However, 0.9 mg/kg/min of
propofol produce significantly greater cardiac depression in jaundiced rat. Similar
finding is observed ex-vivo experiment.
The experiments are well designed and the findings are interesting and
reasonable.
Major Concerns about this paper
1. The authors should seek help for professional English editing before
considering re-submit it again
2. The authors should put more effort to discuss the clinical significance for their
findings. The conclusion should be modified to define well what they have
investigated. For example: propofol appears to be a safe alternative anesthetics
agent in patients with obstructive jaundice and normal cardiac function at low and
intermediate doses.
Minor issues:
1. Why only male rats were chosen. Does sex hormone plays any role?
2. Table 1 can be omitted by simply describing them in the text.
3. Is there any potential correlation between level of TBIL or ALT and effects of
propofol?
Level of interest: An article of importance in its field
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:In vivo and ex vivo effects of propofol on myocardial performance in rats
with obstructive jaundice
Version: 6Date:23 June 2011
Reviewer: renyu liu
Reviewer's report:
Comments:
The authors extensively investigated the effects of propofol on myocardial
performance in both in vivo and in vitro. They found that there is no significant
effect on cardiac contractility from low or intermediate dose of propofol in
obstructive jaundice with normal cardiac function. However, 0.9 mg/kg/min of
propofol produce significantly greater cardiac depression in jaundiced rat. Similar
finding is observed ex-vivo experiment.
The experiments are well designed and the findings are interesting and
reasonable.
Major Concerns about this paper
1. The authors should seek help for professional English editing before
considering re-submit it again
2. The authors should put more effort to discuss the clinical significance for their
findings. The conclusion should be modified to define well what they have
investigated. For example: propofol appears to be a safe alternative anesthetics
agent in patients with obstructive jaundice and normal cardiac function at low and
intermediate doses.
Minor issues:
1. Why only male rats were chosen. Does sex hormone plays any role?
2. Table 1 can be omitted by simply describing them in the text.
3. Is there any potential correlation between level of TBIL or ALT and effects of
propofol?
Level of interest: An article of importance in its field
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, and I have assessed the statistics in my report.
Declaration of competing interests:
I declare that I have no competing interests
assistant