Reviewer's report
Title:Fatty liver index correlates with non-alcoholic fatty liver disease, but not
with newly diagnosed coronary artery atherosclerotic disease in Chinese patients
Version: 1Date:18 February 2013
Reviewer: Gianluca Perseghin
Reviewer's report:
The manuscript by Zhao-Yan Jiang et al is focused on a set of patients recruited
in a consecutive fashion to perform coronary angiograms in the suspect of CAD.
These individuals also underwent abdominal US of the liver to assess the bight
aspect of liver steatosis and fatty liver index (FLI was calculated based on BMI,
waist, serum triglycerides and ggt levels in a Chinese population of 713
individuals (among them 574 had abdominal US).
The authors report a good association between FLI and US-determined NAFLD,
meanwhile a lack of association between NAFLD and FLI with CAD.
Specific comments
1) I am wondering whether drug therapy was collected in this population. Since
NAFLD is associated with a higher rate of overweight, diabetes, hypertension
and dyslipidemia I am wondering whether these individuals with NAFLD were
“overtreated” with respect to those without NAFLD. This is important to know for
the potential readers of the manuscript. Drug therapy may have an impact on
NAFLD, but also on progression of atherosclerosis.
2) The authors with this respect should put emphasis on the cross-sectional
nature of the study and should discuss the consequent limitations
3) To this end I believe that it is very important to check for the potential readers
the anthopometric, biochemical and therapeutic features of the study subjects
based on the three categories of FLI.
4) Table 4; why don’t you report also data about ALT ?
5) Are data about HbA1c available in this population ?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no Competing Interest of any reason
Reviewer's report
Title:Fatty liver index correlates with non-alcoholic fatty liver disease, but not
with newly diagnosed coronary artery atherosclerotic disease in Chinese patients
Version: 1Date:18 February 2013
Reviewer: Gianluca Perseghin
Reviewer's report:
The manuscript by Zhao-Yan Jiang et al is focused on a set of patients recruited
in a consecutive fashion to perform coronary angiograms in the suspect of CAD.
These individuals also underwent abdominal US of the liver to assess the bight
aspect of liver steatosis and fatty liver index (FLI was calculated based on BMI,
waist, serum triglycerides and ggt levels in a Chinese population of 713
individuals (among them 574 had abdominal US).
The authors report a good association between FLI and US-determined NAFLD,
meanwhile a lack of association between NAFLD and FLI with CAD.
Specific comments
1) I am wondering whether drug therapy was collected in this population. Since
NAFLD is associated with a higher rate of overweight, diabetes, hypertension
and dyslipidemia I am wondering whether these individuals with NAFLD were
“overtreated” with respect to those without NAFLD. This is important to know for
the potential readers of the manuscript. Drug therapy may have an impact on
NAFLD, but also on progression of atherosclerosis.
2) The authors with this respect should put emphasis on the cross-sectional
nature of the study and should discuss the consequent limitations
3) To this end I believe that it is very important to check for the potential readers
the anthopometric, biochemical and therapeutic features of the study subjects
based on the three categories of FLI.
4) Table 4; why don’t you report also data about ALT ?
5) Are data about HbA1c available in this population ?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no Competing Interest of any reason
Please review this paper.
user
Reviewer's report
Title:Fatty liver index correlates with non-alcoholic fatty liver disease, but not
with newly diagnosed coronary artery atherosclerotic disease in Chinese patients
Version: 1Date:18 February 2013
Reviewer: Gianluca Perseghin
Reviewer's report:
The manuscript by Zhao-Yan Jiang et al is focused on a set of patients recruited
in a consecutive fashion to perform coronary angiograms in the suspect of CAD.
These individuals also underwent abdominal US of the liver to assess the bight
aspect of liver steatosis and fatty liver index (FLI was calculated based on BMI,
waist, serum triglycerides and ggt levels in a Chinese population of 713
individuals (among them 574 had abdominal US).
The authors report a good association between FLI and US-determined NAFLD,
meanwhile a lack of association between NAFLD and FLI with CAD.
Specific comments
1) I am wondering whether drug therapy was collected in this population. Since
NAFLD is associated with a higher rate of overweight, diabetes, hypertension
and dyslipidemia I am wondering whether these individuals with NAFLD were
“overtreated” with respect to those without NAFLD. This is important to know for
the potential readers of the manuscript. Drug therapy may have an impact on
NAFLD, but also on progression of atherosclerosis.
2) The authors with this respect should put emphasis on the cross-sectional
nature of the study and should discuss the consequent limitations
3) To this end I believe that it is very important to check for the potential readers
the anthopometric, biochemical and therapeutic features of the study subjects
based on the three categories of FLI.
4) Table 4; why don’t you report also data about ALT ?
5) Are data about HbA1c available in this population ?
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I have no Competing Interest of any reason
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