Reviewer's report
Title:Impaired Mitochondrial beta-Oxidation in Patients with Chronic Hepatitis C:
Relation with Viral Load and Insulin Resistance
Version: 1Date:2 December 2012
Reviewer: Amedeo Lonardo
Reviewer's report:
SPECIFIC COMMENT
MAJOR
1. Improve the explanation of the rationale underlying this study: reference to
adult Adult-onset type 2 citrullinemia is quite difficult to understand.
2. Define criteria for inclusion of healthy contrls.
3. Expand the series of individuals with chronic hepatitis C to at least 100 cases
4. Include a second control group of age and gender-matched patients with
chronic hepatitis B/NASH
5. Use multivariate analysis to assess independent predictors of impaired
mitochondrial beta-oxidation: is it HCV or is it liver histology (irrespective of
etiology).
6. Discuss the limitations of the study: is there any possibility for spurious
findings ?
MINOR
1. Editing by a native English speaker is recommended
2. Seven figures are uncommon.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Reviewer's report
Title:Impaired Mitochondrial beta-Oxidation in Patients with Chronic Hepatitis C:
Relation with Viral Load and Insulin Resistance
Version: 1Date:2 December 2012
Reviewer: Amedeo Lonardo
Reviewer's report:
SPECIFIC COMMENT
MAJOR
1. Improve the explanation of the rationale underlying this study: reference to
adult Adult-onset type 2 citrullinemia is quite difficult to understand.
2. Define criteria for inclusion of healthy contrls.
3. Expand the series of individuals with chronic hepatitis C to at least 100 cases
4. Include a second control group of age and gender-matched patients with
chronic hepatitis B/NASH
5. Use multivariate analysis to assess independent predictors of impaired
mitochondrial beta-oxidation: is it HCV or is it liver histology (irrespective of
etiology).
6. Discuss the limitations of the study: is there any possibility for spurious
findings ?
MINOR
1. Editing by a native English speaker is recommended
2. Seven figures are uncommon.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
Please review this paper.
user
Reviewer's report
Title:Impaired Mitochondrial beta-Oxidation in Patients with Chronic Hepatitis C:
Relation with Viral Load and Insulin Resistance
Version: 1Date:2 December 2012
Reviewer: Amedeo Lonardo
Reviewer's report:
SPECIFIC COMMENT
MAJOR
1. Improve the explanation of the rationale underlying this study: reference to
adult Adult-onset type 2 citrullinemia is quite difficult to understand.
2. Define criteria for inclusion of healthy contrls.
3. Expand the series of individuals with chronic hepatitis C to at least 100 cases
4. Include a second control group of age and gender-matched patients with
chronic hepatitis B/NASH
5. Use multivariate analysis to assess independent predictors of impaired
mitochondrial beta-oxidation: is it HCV or is it liver histology (irrespective of
etiology).
6. Discuss the limitations of the study: is there any possibility for spurious
findings ?
MINOR
1. Editing by a native English speaker is recommended
2. Seven figures are uncommon.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, and I have assessed the statistics in my report.
assistant