Reviewer's report
Title:Supplementation with vitamin E (alpha-tocopherol) in diabetic rats: effects
on the proximal colon
Version: 1Date:4 June 2009
Reviewer: MC C SABU
Reviewer's report:
Major Compulsory Revisions
1. Page 5; What is the content of Standardized chow and how it differ from
balanced chow and patronized chow.
2.If there is difference between the chow; Why the author used standardized
chow for the group D alone. How one can compare the different feed groups in
one experiment. If so where is the control group for each type feeds.
3.Since the drug was added to the patronized chow, How the author confirmed
the induvidual rats per group consumed the specified dose of the test drug
4.For supporting the dose consumption, whether the author checked the daily
food consumption. Clarify how the 5 rats per group divided their drug mixed
patronized chow based on their body weight and dose level
5. Page 8; in the result the author mentioned the typical clinic manifestations of
the disease were measured. But it was not mentioned in the method as well as in
tables. In Table 1. it is not mentioned the initial body weight, glucose level and
other important datas for polyphagia, polydipsia and polyuria
6.Figure 3; The author showed only normal and diabetic animal
Photomicrography of the proximal colon. Why the treatment groups
photomicrography is not included
7.In Table 1, The glycemia level of group DE1 is more than group D. Explain the
possibility of increasing blood glucose after drug treatment
Minor Essential Revisions
1. Please check the spelling of Heart punction (Page 6), embebbed (page 7),
Figura 1 (page 8)
2. Reference has to be formatted as per journal rule. Some corrections I am
pointing below a) After author names do not use (.) and use (:)
b) Do not use et al. Write all author names
c) After journal name use (,)
d) Page number should be written in full
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Supplementation with vitamin E (alpha-tocopherol) in diabetic rats: effects
on the proximal colon
Version: 1Date:4 June 2009
Reviewer: MC C SABU
Reviewer's report:
Major Compulsory Revisions
1. Page 5; What is the content of Standardized chow and how it differ from
balanced chow and patronized chow.
2.If there is difference between the chow; Why the author used standardized
chow for the group D alone. How one can compare the different feed groups in
one experiment. If so where is the control group for each type feeds.
3.Since the drug was added to the patronized chow, How the author confirmed
the induvidual rats per group consumed the specified dose of the test drug
4.For supporting the dose consumption, whether the author checked the daily
food consumption. Clarify how the 5 rats per group divided their drug mixed
patronized chow based on their body weight and dose level
5. Page 8; in the result the author mentioned the typical clinic manifestations of
the disease were measured. But it was not mentioned in the method as well as in
tables. In Table 1. it is not mentioned the initial body weight, glucose level and
other important datas for polyphagia, polydipsia and polyuria
6.Figure 3; The author showed only normal and diabetic animal
Photomicrography of the proximal colon. Why the treatment groups
photomicrography is not included
7.In Table 1, The glycemia level of group DE1 is more than group D. Explain the
possibility of increasing blood glucose after drug treatment
Minor Essential Revisions
1. Please check the spelling of Heart punction (Page 6), embebbed (page 7),
Figura 1 (page 8)
2. Reference has to be formatted as per journal rule. Some corrections I am
pointing below a) After author names do not use (.) and use (:)
b) Do not use et al. Write all author names
c) After journal name use (,)
d) Page number should be written in full
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Supplementation with vitamin E (alpha-tocopherol) in diabetic rats: effects
on the proximal colon
Version: 1Date:4 June 2009
Reviewer: MC C SABU
Reviewer's report:
Major Compulsory Revisions
1. Page 5; What is the content of Standardized chow and how it differ from
balanced chow and patronized chow.
2.If there is difference between the chow; Why the author used standardized
chow for the group D alone. How one can compare the different feed groups in
one experiment. If so where is the control group for each type feeds.
3.Since the drug was added to the patronized chow, How the author confirmed
the induvidual rats per group consumed the specified dose of the test drug
4.For supporting the dose consumption, whether the author checked the daily
food consumption. Clarify how the 5 rats per group divided their drug mixed
patronized chow based on their body weight and dose level
5. Page 8; in the result the author mentioned the typical clinic manifestations of
the disease were measured. But it was not mentioned in the method as well as in
tables. In Table 1. it is not mentioned the initial body weight, glucose level and
other important datas for polyphagia, polydipsia and polyuria
6.Figure 3; The author showed only normal and diabetic animal
Photomicrography of the proximal colon. Why the treatment groups
photomicrography is not included
7.In Table 1, The glycemia level of group DE1 is more than group D. Explain the
possibility of increasing blood glucose after drug treatment
Minor Essential Revisions
1. Please check the spelling of Heart punction (Page 6), embebbed (page 7),
Figura 1 (page 8)
2. Reference has to be formatted as per journal rule. Some corrections I am
pointing below a) After author names do not use (.) and use (:)
b) Do not use et al. Write all author names
c) After journal name use (,)
d) Page number should be written in full
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant