Title: Effect of Helicobacter pylori Eradication on Metabolic Profile: An International,
Multicenter, Case-Control Study
Version: 4 Date: 26 Nov 2022
Reviewer's report:
“Two weeks after the end of the treatment period and discontinuation of the drugs, a stool
antigen test (SATs) performed to prove the eradication and the effectiveness of the treatment.”
Many guidelines recommend that to determine whether the eradication of HP is successful
should be at least 4 weeks after the end of the treatment period. Why did the present study
perform SATs 2 weeks after discontinuation of the drugs? Will false negative test results
increase after 2 weeks of drug withdrawal, thus affecting the results of the present study?
Response: dear reviewer, our protocol was same as global approved method and after
completion of 2 weeks treatment with eradication regimen, the PPI continued for four
more weeks, then the participants evaluated for eradication or failure 2 weeks after a 6
weeks period (week 8, added to the method section).
No modification of this part is seen in the revised article. Please add this part to the article.
Title: Effect of Helicobacter pylori Eradication on Metabolic Profile: An International,
Multicenter, Case-Control Study
Version: 4 Date: 26 Nov 2022
Reviewer's report:
“Two weeks after the end of the treatment period and discontinuation of the drugs, a stool
antigen test (SATs) performed to prove the eradication and the effectiveness of the treatment.”
Many guidelines recommend that to determine whether the eradication of HP is successful
should be at least 4 weeks after the end of the treatment period. Why did the present study
perform SATs 2 weeks after discontinuation of the drugs? Will false negative test results
increase after 2 weeks of drug withdrawal, thus affecting the results of the present study?
Response: dear reviewer, our protocol was same as global approved method and after
completion of 2 weeks treatment with eradication regimen, the PPI continued for four
more weeks, then the participants evaluated for eradication or failure 2 weeks after a 6
weeks period (week 8, added to the method section).
No modification of this part is seen in the revised article. Please add this part to the article.
Please review this paper.
user
Title: Effect of Helicobacter pylori Eradication on Metabolic Profile: An International,
Multicenter, Case-Control Study
Version: 4 Date: 26 Nov 2022
Reviewer's report:
“Two weeks after the end of the treatment period and discontinuation of the drugs, a stool
antigen test (SATs) performed to prove the eradication and the effectiveness of the treatment.”
Many guidelines recommend that to determine whether the eradication of HP is successful
should be at least 4 weeks after the end of the treatment period. Why did the present study
perform SATs 2 weeks after discontinuation of the drugs? Will false negative test results
increase after 2 weeks of drug withdrawal, thus affecting the results of the present study?
Response: dear reviewer, our protocol was same as global approved method and after
completion of 2 weeks treatment with eradication regimen, the PPI continued for four
more weeks, then the participants evaluated for eradication or failure 2 weeks after a 6
weeks period (week 8, added to the method section).
No modification of this part is seen in the revised article. Please add this part to the article.
assistant