Title: Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of Immune
Checkpoint Inhibitors in Gastric Cancer
Version: 1 Date: 26 Jan 2023
Reviewer's report:
In this study, the authors aimed toexplore the prognostic value of #1 integrin (ITGB1) and its
relationship with immune infiltration of the gastric region cancer.  The conclusions of this study
suggest that ITGB1 may be a promising prognostic biomarker and effective predictor for anti-
PD1 therapy in GC. There are obvious defects in this study.
1. There have been many reports on ITGB1 and immune of gastric cancer, so this study does
not show obvious innovation.
2. The authors did not explore the molecular mechanism of ITGB1 in regulating immune
infiltration of gastric cancer.
3. The sample collected by the author is too limited to verify the accuracy of data in the database.
4. The English level of this manuscript should be carefully revised.
Title: Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of Immune
Checkpoint Inhibitors in Gastric Cancer
Version: 1 Date: 26 Jan 2023
Reviewer's report:
In this study, the authors aimed toexplore the prognostic value of #1 integrin (ITGB1) and its
relationship with immune infiltration of the gastric region cancer.  The conclusions of this study
suggest that ITGB1 may be a promising prognostic biomarker and effective predictor for anti-
PD1 therapy in GC. There are obvious defects in this study.
1. There have been many reports on ITGB1 and immune of gastric cancer, so this study does
not show obvious innovation.
2. The authors did not explore the molecular mechanism of ITGB1 in regulating immune
infiltration of gastric cancer.
3. The sample collected by the author is too limited to verify the accuracy of data in the database.
4. The English level of this manuscript should be carefully revised.
Please review this paper.
user
Title: Evaluation of ITGB1 Expression as a Predictor of the Therapeutic Effects of Immune
Checkpoint Inhibitors in Gastric Cancer
Version: 1 Date: 26 Jan 2023
Reviewer's report:
In this study, the authors aimed toexplore the prognostic value of #1 integrin (ITGB1) and its
relationship with immune infiltration of the gastric region cancer.  The conclusions of this study
suggest that ITGB1 may be a promising prognostic biomarker and effective predictor for anti-
PD1 therapy in GC. There are obvious defects in this study.
1. There have been many reports on ITGB1 and immune of gastric cancer, so this study does
not show obvious innovation.
2. The authors did not explore the molecular mechanism of ITGB1 in regulating immune
infiltration of gastric cancer.
3. The sample collected by the author is too limited to verify the accuracy of data in the database.
4. The English level of this manuscript should be carefully revised.
assistant