Reviewer's report
Title:Expression of NALPs in adipose and the fibrotic progression of NAFLD in
obese subjects
Version:1Date:11 September 2014
Reviewer: sammy saab
Reviewer's report:
I read with great interest the manuscript by Mehta et al. The paper is very well
written and timely. Fatty liver is the common cause of hepatitis in the United
States. Despite the prevalence and health care utilization implication, our
understanding of the pathogenesis and not really evolved over the past 5-10
years. The work by Mehta et al provide some insight into possible signal
translation of fatty liver.
I just have minor comments.
Which visceral tissue was biopsied and does it matter?
How is inflammation defined? Are there different degrees or
severities?
The paper would benefit from a schematic representation of
the signals/pathways
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
No to all
Reviewer's report
Title:Expression of NALPs in adipose and the fibrotic progression of NAFLD in
obese subjects
Version:1Date:11 September 2014
Reviewer: sammy saab
Reviewer's report:
I read with great interest the manuscript by Mehta et al. The paper is very well
written and timely. Fatty liver is the common cause of hepatitis in the United
States. Despite the prevalence and health care utilization implication, our
understanding of the pathogenesis and not really evolved over the past 5-10
years. The work by Mehta et al provide some insight into possible signal
translation of fatty liver.
I just have minor comments.
Which visceral tissue was biopsied and does it matter?
How is inflammation defined? Are there different degrees or
severities?
The paper would benefit from a schematic representation of
the signals/pathways
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
No to all
Please review this paper.
user
Reviewer's report
Title:Expression of NALPs in adipose and the fibrotic progression of NAFLD in
obese subjects
Version:1Date:11 September 2014
Reviewer: sammy saab
Reviewer's report:
I read with great interest the manuscript by Mehta et al. The paper is very well
written and timely. Fatty liver is the common cause of hepatitis in the United
States. Despite the prevalence and health care utilization implication, our
understanding of the pathogenesis and not really evolved over the past 5-10
years. The work by Mehta et al provide some insight into possible signal
translation of fatty liver.
I just have minor comments.
Which visceral tissue was biopsied and does it matter?
How is inflammation defined? Are there different degrees or
severities?
The paper would benefit from a schematic representation of
the signals/pathways
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
No to all
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