Title: A Novel Nomogram to Predict 90-Day Mortality in Patients with Hepatitis B Virus-
Related Acute-on-Chronic Liver Failure: A Single-Center Retrospective Study
Version: 1 Date: 01 Nov 2022
Reviewer:  Tarana Gupta
Reviewer's report:
The article prepares a nomogram for prediction of 90-day mortality in HBV-ACLF.
I have few issues.
1. In introduction authors state that HBV-ACLF constitutes 70% of ACLF. I think this is correct
in a regional or few geographical settings. Should be improved.
2. This is a retrospective study. Therefore there would be bias on data collection etc.
3. Is this nomogram other than prediction of mortality has been evaluated for response to
treatment.
4. Authors should also include the management protocol used for HBV-ACLF.
5. The HBV parameters including HBV DNA quantitative levels, IgM anti-HBc levels and
positivity, HBeAg status, HBsAg quantitative levels should be included in formation of any
prediction model for HBV-ACLF.
6. All parameters should be taken into consideration for HBV-ACLF, only then we can say that
this is better for prediction of 90-day mortality as compared to generalised scores like MELD,
CLIF-OF score etc.
Title: A Novel Nomogram to Predict 90-Day Mortality in Patients with Hepatitis B Virus-
Related Acute-on-Chronic Liver Failure: A Single-Center Retrospective Study
Version: 1 Date: 01 Nov 2022
Reviewer:  Tarana Gupta
Reviewer's report:
The article prepares a nomogram for prediction of 90-day mortality in HBV-ACLF.
I have few issues.
1. In introduction authors state that HBV-ACLF constitutes 70% of ACLF. I think this is correct
in a regional or few geographical settings. Should be improved.
2. This is a retrospective study. Therefore there would be bias on data collection etc.
3. Is this nomogram other than prediction of mortality has been evaluated for response to
treatment.
4. Authors should also include the management protocol used for HBV-ACLF.
5. The HBV parameters including HBV DNA quantitative levels, IgM anti-HBc levels and
positivity, HBeAg status, HBsAg quantitative levels should be included in formation of any
prediction model for HBV-ACLF.
6. All parameters should be taken into consideration for HBV-ACLF, only then we can say that
this is better for prediction of 90-day mortality as compared to generalised scores like MELD,
CLIF-OF score etc.
Please review this paper.
user
Title: A Novel Nomogram to Predict 90-Day Mortality in Patients with Hepatitis B Virus-
Related Acute-on-Chronic Liver Failure: A Single-Center Retrospective Study
Version: 1 Date: 01 Nov 2022
Reviewer:  Tarana Gupta
Reviewer's report:
The article prepares a nomogram for prediction of 90-day mortality in HBV-ACLF.
I have few issues.
1. In introduction authors state that HBV-ACLF constitutes 70% of ACLF. I think this is correct
in a regional or few geographical settings. Should be improved.
2. This is a retrospective study. Therefore there would be bias on data collection etc.
3. Is this nomogram other than prediction of mortality has been evaluated for response to
treatment.
4. Authors should also include the management protocol used for HBV-ACLF.
5. The HBV parameters including HBV DNA quantitative levels, IgM anti-HBc levels and
positivity, HBeAg status, HBsAg quantitative levels should be included in formation of any
prediction model for HBV-ACLF.
6. All parameters should be taken into consideration for HBV-ACLF, only then we can say that
this is better for prediction of 90-day mortality as compared to generalised scores like MELD,
CLIF-OF score etc.
assistant