Title: The effect of BMI on long-term outcome in patients with rectal cancer and establishment
of a nomogram prediction model
Version: 3 Date: 24 Nov 2022
Reviewer's report:
The authors investigated the effect of body mass index (BMI) on rectal cancer patients and
showed that overweight is an independent protective factor for OS and DFS in rectal cancer
patients after radical surgery, and that underweight is an independent risk factor for DFS and
tends to be an independent risk factor for OS. The study also showed that BMI and other
prognostic factors are also associated with OS and DFS. A nomogram incorporating BMI and
other prognostic factors was also developed and shown to be a possible predictor of long-term
prognosis.
Although these are very interesting, some revisions are needed for publication.
(1) I consider that each group's nutritional status needs to be assessed. Therefore, I would like
to see a comparison of laboratory data such as albumin and cholinesterase.
(2) What do you think about the fact that the underweight group had poorer DFS than the
other groups? For example, is there a difference in the adjuvant therapy regimen, total dose, or
radiation dose or field?
Title: The effect of BMI on long-term outcome in patients with rectal cancer and establishment
of a nomogram prediction model
Version: 3 Date: 24 Nov 2022
Reviewer's report:
The authors investigated the effect of body mass index (BMI) on rectal cancer patients and
showed that overweight is an independent protective factor for OS and DFS in rectal cancer
patients after radical surgery, and that underweight is an independent risk factor for DFS and
tends to be an independent risk factor for OS. The study also showed that BMI and other
prognostic factors are also associated with OS and DFS. A nomogram incorporating BMI and
other prognostic factors was also developed and shown to be a possible predictor of long-term
prognosis.
Although these are very interesting, some revisions are needed for publication.
(1) I consider that each group's nutritional status needs to be assessed. Therefore, I would like
to see a comparison of laboratory data such as albumin and cholinesterase.
(2) What do you think about the fact that the underweight group had poorer DFS than the
other groups? For example, is there a difference in the adjuvant therapy regimen, total dose, or
radiation dose or field?
Please review this paper.
user
Title: The effect of BMI on long-term outcome in patients with rectal cancer and establishment
of a nomogram prediction model
Version: 3 Date: 24 Nov 2022
Reviewer's report:
The authors investigated the effect of body mass index (BMI) on rectal cancer patients and
showed that overweight is an independent protective factor for OS and DFS in rectal cancer
patients after radical surgery, and that underweight is an independent risk factor for DFS and
tends to be an independent risk factor for OS. The study also showed that BMI and other
prognostic factors are also associated with OS and DFS. A nomogram incorporating BMI and
other prognostic factors was also developed and shown to be a possible predictor of long-term
prognosis.
Although these are very interesting, some revisions are needed for publication.
(1) I consider that each group's nutritional status needs to be assessed. Therefore, I would like
to see a comparison of laboratory data such as albumin and cholinesterase.
(2) What do you think about the fact that the underweight group had poorer DFS than the
other groups? For example, is there a difference in the adjuvant therapy regimen, total dose, or
radiation dose or field?
assistant