Reviewer's report
Title:A new family with hereditary lysozyme amyloidosis with gastritis and
inflammatory bowel disease as prevailing symptoms.
Version:4Date:23 June 2014
Reviewer: Saulius Girnius
Reviewer's report:
To Whom It May Concern:
Thank you for the opportunity to review the article named “A new family with
hereditary lysozyme amyloidosis with gastritis and inflammatory bowel disease
as prevailing symptoms” by Dr. Estelle Jean et al. In this paper, the authors
present a new family of hereditary amyloidosis with Trp82Arg, previously
described as Trp64Arg.
This paper is certainly justified to be published in a journal read by
gastroenterologist, not only to for scientific interest by describing a new family,
but also increase awareness for amyloidosis. As typical for patients with
amyloidosis, the proband had multiple endoscopies without a diagnosis and had
been treated with medications that were not effective, although a PPI certainly
has minimal harm. Increased awareness could lead to faster diagnosis.
Discretionary Revisions
There are multiple small grammatical errors, but these are easily fixed and
should not adversely affect the decision to publish. Listed are a few examples,
but there are others
1) Abstract, second paragraph. “To describe symptoms and Gi tract involvement
in a new family with hereditary lysozyme amyloidosis”. This is not a complete
sentence.
2) Abstract, conclusion: “evoke” is used incorrectly. Consider writing “Amyloidosis
should be considered in atypical or treatment resistant, upper or lower chronic
gastrointestinal symptom”
3) There are multiple minor grammatical errors in this paper, for instance:
“Lysozyme amyloidosis (ALys) belongs to the group of hereditary
non-neuropathic systemic amyloidosis” Should change “systemic amyloidosis” to
“systemic amyloidoses
Was the hepatomegaly on exam or imaging? I believe the protein C reactive is
more commonly know as C reactive protein.
I am curious, did any treatment help the proband? Or did she continue to have
stable, GERD symptoms
Minor Essential Revisions.
Three of the proband’s siblings had the diagnosis of inflammatory bowel disease.
The description suggests that the diagnosis was made based on visualization,
rather than biopsy. Is this correct? Do you believe these patients had
concomitant IBD or just mis-diagnosed? Since symptoms improved with
mesalamine, would you consider mesalamine a possible treatment?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No. I do not have any competing interests
Reviewer's report
Title:A new family with hereditary lysozyme amyloidosis with gastritis and
inflammatory bowel disease as prevailing symptoms.
Version:4Date:23 June 2014
Reviewer: Saulius Girnius
Reviewer's report:
To Whom It May Concern:
Thank you for the opportunity to review the article named “A new family with
hereditary lysozyme amyloidosis with gastritis and inflammatory bowel disease
as prevailing symptoms” by Dr. Estelle Jean et al. In this paper, the authors
present a new family of hereditary amyloidosis with Trp82Arg, previously
described as Trp64Arg.
This paper is certainly justified to be published in a journal read by
gastroenterologist, not only to for scientific interest by describing a new family,
but also increase awareness for amyloidosis. As typical for patients with
amyloidosis, the proband had multiple endoscopies without a diagnosis and had
been treated with medications that were not effective, although a PPI certainly
has minimal harm. Increased awareness could lead to faster diagnosis.
Discretionary Revisions
There are multiple small grammatical errors, but these are easily fixed and
should not adversely affect the decision to publish. Listed are a few examples,
but there are others
1) Abstract, second paragraph. “To describe symptoms and Gi tract involvement
in a new family with hereditary lysozyme amyloidosis”. This is not a complete
sentence.
2) Abstract, conclusion: “evoke” is used incorrectly. Consider writing “Amyloidosis
should be considered in atypical or treatment resistant, upper or lower chronic
gastrointestinal symptom”
3) There are multiple minor grammatical errors in this paper, for instance:
“Lysozyme amyloidosis (ALys) belongs to the group of hereditary
non-neuropathic systemic amyloidosis” Should change “systemic amyloidosis” to
“systemic amyloidoses
Was the hepatomegaly on exam or imaging? I believe the protein C reactive is
more commonly know as C reactive protein.
I am curious, did any treatment help the proband? Or did she continue to have
stable, GERD symptoms
Minor Essential Revisions.
Three of the proband’s siblings had the diagnosis of inflammatory bowel disease.
The description suggests that the diagnosis was made based on visualization,
rather than biopsy. Is this correct? Do you believe these patients had
concomitant IBD or just mis-diagnosed? Since symptoms improved with
mesalamine, would you consider mesalamine a possible treatment?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No. I do not have any competing interests
Please review this paper.
user
Reviewer's report
Title:A new family with hereditary lysozyme amyloidosis with gastritis and
inflammatory bowel disease as prevailing symptoms.
Version:4Date:23 June 2014
Reviewer: Saulius Girnius
Reviewer's report:
To Whom It May Concern:
Thank you for the opportunity to review the article named “A new family with
hereditary lysozyme amyloidosis with gastritis and inflammatory bowel disease
as prevailing symptoms” by Dr. Estelle Jean et al. In this paper, the authors
present a new family of hereditary amyloidosis with Trp82Arg, previously
described as Trp64Arg.
This paper is certainly justified to be published in a journal read by
gastroenterologist, not only to for scientific interest by describing a new family,
but also increase awareness for amyloidosis. As typical for patients with
amyloidosis, the proband had multiple endoscopies without a diagnosis and had
been treated with medications that were not effective, although a PPI certainly
has minimal harm. Increased awareness could lead to faster diagnosis.
Discretionary Revisions
There are multiple small grammatical errors, but these are easily fixed and
should not adversely affect the decision to publish. Listed are a few examples,
but there are others
1) Abstract, second paragraph. “To describe symptoms and Gi tract involvement
in a new family with hereditary lysozyme amyloidosis”. This is not a complete
sentence.
2) Abstract, conclusion: “evoke” is used incorrectly. Consider writing “Amyloidosis
should be considered in atypical or treatment resistant, upper or lower chronic
gastrointestinal symptom”
3) There are multiple minor grammatical errors in this paper, for instance:
“Lysozyme amyloidosis (ALys) belongs to the group of hereditary
non-neuropathic systemic amyloidosis” Should change “systemic amyloidosis” to
“systemic amyloidoses
Was the hepatomegaly on exam or imaging? I believe the protein C reactive is
more commonly know as C reactive protein.
I am curious, did any treatment help the proband? Or did she continue to have
stable, GERD symptoms
Minor Essential Revisions.
Three of the proband’s siblings had the diagnosis of inflammatory bowel disease.
The description suggests that the diagnosis was made based on visualization,
rather than biopsy. Is this correct? Do you believe these patients had
concomitant IBD or just mis-diagnosed? Since symptoms improved with
mesalamine, would you consider mesalamine a possible treatment?
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No. I do not have any competing interests
assistant