Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 2 Date: 12 Jan 2021
Reviewer's report:
The authors explore the role of AKI on survival after variceal bleeding in cirrhotic patients
- The study, although retrospective, includes a consistent number of cases but therew are some
points of concern that could have influenced the results.
1. The authors stated that 128/153 patients had diagnosis of AKi at admission while 7 developed
it during the ho.spitalisation. ICA AKI criteria establish an increase of 0.3 mg creatinine within
48 h or an increase>50% creatinine from baseline within 3 months.
The authors included cases with a baseline levels of creatinine>3 months  till 1 year. In patients
with advanced liver cirrhosis( as the majority of patients included) it may be infuenced by many
factors and can be fluctuating so creatinine value older than three months should be sxluded
from the analysis.
2. How many patients had diagnosis of AKi with a creatinine increase of 0,3 mg within 48 hours?
3.How many patients had diagnosis of AKI with an increase of creatinine >50% from baseline
within 3 months?
4.It is necessary to describe in the text how the authors diagnosed the causes of AKi
Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 2 Date: 12 Jan 2021
Reviewer's report:
The authors explore the role of AKI on survival after variceal bleeding in cirrhotic patients
- The study, although retrospective, includes a consistent number of cases but therew are some
points of concern that could have influenced the results.
1. The authors stated that 128/153 patients had diagnosis of AKi at admission while 7 developed
it during the ho.spitalisation. ICA AKI criteria establish an increase of 0.3 mg creatinine within
48 h or an increase>50% creatinine from baseline within 3 months.
The authors included cases with a baseline levels of creatinine>3 months  till 1 year. In patients
with advanced liver cirrhosis( as the majority of patients included) it may be infuenced by many
factors and can be fluctuating so creatinine value older than three months should be sxluded
from the analysis.
2. How many patients had diagnosis of AKi with a creatinine increase of 0,3 mg within 48 hours?
3.How many patients had diagnosis of AKI with an increase of creatinine >50% from baseline
within 3 months?
4.It is necessary to describe in the text how the authors diagnosed the causes of AKi
Please review this paper.
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Title: Impact of Acute Kidney Injury on Mortality in Patients with Acute Variceal Bleeding
Version: 2 Date: 12 Jan 2021
Reviewer's report:
The authors explore the role of AKI on survival after variceal bleeding in cirrhotic patients
- The study, although retrospective, includes a consistent number of cases but therew are some
points of concern that could have influenced the results.
1. The authors stated that 128/153 patients had diagnosis of AKi at admission while 7 developed
it during the ho.spitalisation. ICA AKI criteria establish an increase of 0.3 mg creatinine within
48 h or an increase>50% creatinine from baseline within 3 months.
The authors included cases with a baseline levels of creatinine>3 months  till 1 year. In patients
with advanced liver cirrhosis( as the majority of patients included) it may be infuenced by many
factors and can be fluctuating so creatinine value older than three months should be sxluded
from the analysis.
2. How many patients had diagnosis of AKi with a creatinine increase of 0,3 mg within 48 hours?
3.How many patients had diagnosis of AKI with an increase of creatinine >50% from baseline
within 3 months?
4.It is necessary to describe in the text how the authors diagnosed the causes of AKi
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