Reviewer's report
Title:Effect of a multispecies probiotic supplement on the quantities of irritable
bowel syndrome-related intestinal microbial phylotypes
Version: 1Date:2 March 2010
Reviewer: Anthony Lembo
Reviewer's report:
Probiotics are commonly used to treat the symptoms of IBS. Questions still
remain on the efficacy of probiotics and little is known about their potential
mechanism of action. The authors in this study using quantitative real-time
polymerase chain reaction evaluated the colonic flora for several different
bacterial species from stored fecal material collected in a previously reported
placebo controlled clinical trial with a combination of probiotics. The findings of
differences in the colonic flora begin to unravel the potential mechanism of action
of probiotics. However, as the authors clearly point out much more work is
needed in this area.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests'
Reviewer's report
Title:Effect of a multispecies probiotic supplement on the quantities of irritable
bowel syndrome-related intestinal microbial phylotypes
Version: 1Date:2 March 2010
Reviewer: Anthony Lembo
Reviewer's report:
Probiotics are commonly used to treat the symptoms of IBS. Questions still
remain on the efficacy of probiotics and little is known about their potential
mechanism of action. The authors in this study using quantitative real-time
polymerase chain reaction evaluated the colonic flora for several different
bacterial species from stored fecal material collected in a previously reported
placebo controlled clinical trial with a combination of probiotics. The findings of
differences in the colonic flora begin to unravel the potential mechanism of action
of probiotics. However, as the authors clearly point out much more work is
needed in this area.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Effect of a multispecies probiotic supplement on the quantities of irritable
bowel syndrome-related intestinal microbial phylotypes
Version: 1Date:2 March 2010
Reviewer: Anthony Lembo
Reviewer's report:
Probiotics are commonly used to treat the symptoms of IBS. Questions still
remain on the efficacy of probiotics and little is known about their potential
mechanism of action. The authors in this study using quantitative real-time
polymerase chain reaction evaluated the colonic flora for several different
bacterial species from stored fecal material collected in a previously reported
placebo controlled clinical trial with a combination of probiotics. The findings of
differences in the colonic flora begin to unravel the potential mechanism of action
of probiotics. However, as the authors clearly point out much more work is
needed in this area.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests'
assistant