Reviewer's report 
 Liver, spleen, pancreas and kidney involvement by human fascioliasis: imaging findings Title: 
 1  26 May 2004 Version: Date: 
 Rasoul Sotoudehmanesh Reviewer: 
Reviewer's report: 
General 
This is a well-described case report of an unusual presentation of fascioliasis. 
------------------------------------------------------------------------------- Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
1. After the diagnosis was established with a positive ELISA test for fasciola, what was the reason 
for choosing albendazole as the first treatment option? (Fasciola hepatica is known to be resistant to albendazole). 2. In page 9 line 4 of first paragraph, what is the meaning of "nuclear" in the sentence? Do the 
authors mean "unclear"? 
3. In page 9, line 19: the authors have stated that "hypersensitivity reaction to fasciola antigens might also be implicated" to explain the imaging findings in their patients. As hypersensitivity reactions are systemic processes without focal organ involvement, is there any 
evidence that confirms this explanation? 
4. References are not numbered consecutively. 5. There is no legend for figure 3-C. 6. The quality of all pictures, especially figure 2, is poor. The authors should provide higher quality 
pictures and a color picture for figure 2 with a higher resolution. 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
The dissemination of the parasite in other organs could be explained by ineffective therapy 
(albendazole) in an immunocompromised patient. A discussion on this matter would be appropriate. 
 Accept after minor essential revisions What next?: 
 An article of limited interest Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
None 
Reviewer's report 
 Liver, spleen, pancreas and kidney involvement by human fascioliasis: imaging findings Title: 
 1  26 May 2004 Version: Date: 
 Rasoul Sotoudehmanesh Reviewer: 
Reviewer's report: 
General 
This is a well-described case report of an unusual presentation of fascioliasis. 
------------------------------------------------------------------------------- Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
1. After the diagnosis was established with a positive ELISA test for fasciola, what was the reason 
for choosing albendazole as the first treatment option? (Fasciola hepatica is known to be resistant to albendazole). 2. In page 9 line 4 of first paragraph, what is the meaning of "nuclear" in the sentence? Do the 
authors mean "unclear"? 
3. In page 9, line 19: the authors have stated that "hypersensitivity reaction to fasciola antigens might also be implicated" to explain the imaging findings in their patients. As hypersensitivity reactions are systemic processes without focal organ involvement, is there any 
evidence that confirms this explanation? 
4. References are not numbered consecutively. 5. There is no legend for figure 3-C. 6. The quality of all pictures, especially figure 2, is poor. The authors should provide higher quality 
pictures and a color picture for figure 2 with a higher resolution. 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
The dissemination of the parasite in other organs could be explained by ineffective therapy 
(albendazole) in an immunocompromised patient. A discussion on this matter would be appropriate. 
 Accept after minor essential revisions What next?: 
 An article of limited interest Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
None 
Please review this paper.
user
Reviewer's report 
 Liver, spleen, pancreas and kidney involvement by human fascioliasis: imaging findings Title: 
 1  26 May 2004 Version: Date: 
 Rasoul Sotoudehmanesh Reviewer: 
Reviewer's report: 
General 
This is a well-described case report of an unusual presentation of fascioliasis. 
------------------------------------------------------------------------------- Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
------------------------------------------------------------------------------- 
Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the author can be trusted to correct) 
1. After the diagnosis was established with a positive ELISA test for fasciola, what was the reason 
for choosing albendazole as the first treatment option? (Fasciola hepatica is known to be resistant to albendazole). 2. In page 9 line 4 of first paragraph, what is the meaning of "nuclear" in the sentence? Do the 
authors mean "unclear"? 
3. In page 9, line 19: the authors have stated that "hypersensitivity reaction to fasciola antigens might also be implicated" to explain the imaging findings in their patients. As hypersensitivity reactions are systemic processes without focal organ involvement, is there any 
evidence that confirms this explanation? 
4. References are not numbered consecutively. 5. There is no legend for figure 3-C. 6. The quality of all pictures, especially figure 2, is poor. The authors should provide higher quality 
pictures and a color picture for figure 2 with a higher resolution. 
------------------------------------------------------------------------------- 
Discretionary Revisions (which the author can choose to ignore) 
The dissemination of the parasite in other organs could be explained by ineffective therapy 
(albendazole) in an immunocompromised patient. A discussion on this matter would be appropriate. 
 Accept after minor essential revisions What next?: 
 An article of limited interest Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 No Statistical review: 
Declaration of competing interests: 
None 
assistant