Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 2 Date: 29 Oct 2024
Reviewer's report:
Some revisions are necessary before it can be considered for acceptance.
1) The authors should provide references  in the section discussing PEG in the introduction.
2)In addition to p-values, the authors should report the odds ratios, as these will offer more
insight into the effect size and clinical relevance of the findings.
3)A multivariate analysis should be included to account for potential confounding variables and
strengthen the reliability of the conclusions.
4)The Methods section mentions the use of ROC curves, yet this analysis is missing in the
Results section. The authors should clarify why this method was chosen for this type of study,
as ROC analysis is typically applied to evaluate the diagnostic accuracy of a test or model.
5)Focusing exclusively on ICU patients indicated for PEG may introduce bias, as these patients
often have conditions—such as brain injuries—that predispose them to gastric mucosal lesions.
These limitations should be discussed, particularly in relation to the generalizability of the
findings.
6)In the Results section, it would be beneficial to include a summary of the clinical indications
for PEG among the study participants
Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 2 Date: 29 Oct 2024
Reviewer's report:
Some revisions are necessary before it can be considered for acceptance.
1) The authors should provide references  in the section discussing PEG in the introduction.
2)In addition to p-values, the authors should report the odds ratios, as these will offer more
insight into the effect size and clinical relevance of the findings.
3)A multivariate analysis should be included to account for potential confounding variables and
strengthen the reliability of the conclusions.
4)The Methods section mentions the use of ROC curves, yet this analysis is missing in the
Results section. The authors should clarify why this method was chosen for this type of study,
as ROC analysis is typically applied to evaluate the diagnostic accuracy of a test or model.
5)Focusing exclusively on ICU patients indicated for PEG may introduce bias, as these patients
often have conditions—such as brain injuries—that predispose them to gastric mucosal lesions.
These limitations should be discussed, particularly in relation to the generalizability of the
findings.
6)In the Results section, it would be beneficial to include a summary of the clinical indications
for PEG among the study participants
Please review this paper.
user
Title: Risk factors for gastric mucosa lesion in critically ill patients undergoing endoscopy for
percutaneous gastrostomy: a case-control study
Version: 2 Date: 29 Oct 2024
Reviewer's report:
Some revisions are necessary before it can be considered for acceptance.
1) The authors should provide references  in the section discussing PEG in the introduction.
2)In addition to p-values, the authors should report the odds ratios, as these will offer more
insight into the effect size and clinical relevance of the findings.
3)A multivariate analysis should be included to account for potential confounding variables and
strengthen the reliability of the conclusions.
4)The Methods section mentions the use of ROC curves, yet this analysis is missing in the
Results section. The authors should clarify why this method was chosen for this type of study,
as ROC analysis is typically applied to evaluate the diagnostic accuracy of a test or model.
5)Focusing exclusively on ICU patients indicated for PEG may introduce bias, as these patients
often have conditions—such as brain injuries—that predispose them to gastric mucosal lesions.
These limitations should be discussed, particularly in relation to the generalizability of the
findings.
6)In the Results section, it would be beneficial to include a summary of the clinical indications
for PEG among the study participants
assistant