Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 14 Sep 2024
Reviewer's report:
Thank you for inviting me to review this paper. The study investigates the causal relationship
between blood metabolites and the development of stomach cancer, using Mendelian
randomization analysis to infer these effects through genetic variation. Here are my review
comments:
1.Structure:he introduction is thorough but could benefit from simplification for clarity. Some
sentences are repetitive; rephrasing them to avoid redundancy will help readers better grasp the
author's message.
2.Research Design:To make the research design more accessible to a broader audience, consider
simplifying complex methodological terms. Breaking down the three hypotheses of Mendelian
randomization into more straightforward language or using footnotes for additional explanations
would be helpful.
3.Instrument Selection:The term "exclude palindromic SNPs with intermediate allele
frequencies such as A/T or G/C" may be unclear to readers without a genetics background.
Adding a brief explanation, such as: "Palindromic SNPs, where two alleles are indistinguishable
(e.g., A/T or G/C), were excluded to prevent analytical ambiguity," could clarify this concept.
4.Discussion:The phrase "In recent times the worldwide prevalence of GC has seen a rise" could
be revised for formality and precision. I recommend: "The global incidence of stomach cancer
has increased in recent years, highlighting the need for early screening and preventive measures."
The statement "To date, only a few studies have delved into the role of circulating 3-methyl-2-
oxyvalerate in tumorigenesis..." would be strengthened by including additional references on
the specific role of 3-methyl-2-oxyvalerate. Incorporating more studies could reinforce this
argument.
5.Charts:Ensure that all chart legends are clear and descriptive, particularly for complex visual
data such as forest plots and meta-analyses. This will aid readers in accurately interpreting the
data.
Overall, this study offers valuable insights into the molecular mechanisms of gastric cancer and
provides a foundation for screening and intervention strategies using metabolites as potential
biomarkers. After addressing the suggested revisions, I believe the paper will be suitable for
publication. Therefore, I recommend it for publication pending comprehensive revision.
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 14 Sep 2024
Reviewer's report:
Thank you for inviting me to review this paper. The study investigates the causal relationship
between blood metabolites and the development of stomach cancer, using Mendelian
randomization analysis to infer these effects through genetic variation. Here are my review
comments:
1.Structure:he introduction is thorough but could benefit from simplification for clarity. Some
sentences are repetitive; rephrasing them to avoid redundancy will help readers better grasp the
author's message.
2.Research Design:To make the research design more accessible to a broader audience, consider
simplifying complex methodological terms. Breaking down the three hypotheses of Mendelian
randomization into more straightforward language or using footnotes for additional explanations
would be helpful.
3.Instrument Selection:The term "exclude palindromic SNPs with intermediate allele
frequencies such as A/T or G/C" may be unclear to readers without a genetics background.
Adding a brief explanation, such as: "Palindromic SNPs, where two alleles are indistinguishable
(e.g., A/T or G/C), were excluded to prevent analytical ambiguity," could clarify this concept.
4.Discussion:The phrase "In recent times the worldwide prevalence of GC has seen a rise" could
be revised for formality and precision. I recommend: "The global incidence of stomach cancer
has increased in recent years, highlighting the need for early screening and preventive measures."
The statement "To date, only a few studies have delved into the role of circulating 3-methyl-2-
oxyvalerate in tumorigenesis..." would be strengthened by including additional references on
the specific role of 3-methyl-2-oxyvalerate. Incorporating more studies could reinforce this
argument.
5.Charts:Ensure that all chart legends are clear and descriptive, particularly for complex visual
data such as forest plots and meta-analyses. This will aid readers in accurately interpreting the
data.
Overall, this study offers valuable insights into the molecular mechanisms of gastric cancer and
provides a foundation for screening and intervention strategies using metabolites as potential
biomarkers. After addressing the suggested revisions, I believe the paper will be suitable for
publication. Therefore, I recommend it for publication pending comprehensive revision.
Please review this paper.
user
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 14 Sep 2024
Reviewer's report:
Thank you for inviting me to review this paper. The study investigates the causal relationship
between blood metabolites and the development of stomach cancer, using Mendelian
randomization analysis to infer these effects through genetic variation. Here are my review
comments:
1.Structure:he introduction is thorough but could benefit from simplification for clarity. Some
sentences are repetitive; rephrasing them to avoid redundancy will help readers better grasp the
author's message.
2.Research Design:To make the research design more accessible to a broader audience, consider
simplifying complex methodological terms. Breaking down the three hypotheses of Mendelian
randomization into more straightforward language or using footnotes for additional explanations
would be helpful.
3.Instrument Selection:The term "exclude palindromic SNPs with intermediate allele
frequencies such as A/T or G/C" may be unclear to readers without a genetics background.
Adding a brief explanation, such as: "Palindromic SNPs, where two alleles are indistinguishable
(e.g., A/T or G/C), were excluded to prevent analytical ambiguity," could clarify this concept.
4.Discussion:The phrase "In recent times the worldwide prevalence of GC has seen a rise" could
be revised for formality and precision. I recommend: "The global incidence of stomach cancer
has increased in recent years, highlighting the need for early screening and preventive measures."
The statement "To date, only a few studies have delved into the role of circulating 3-methyl-2-
oxyvalerate in tumorigenesis..." would be strengthened by including additional references on
the specific role of 3-methyl-2-oxyvalerate. Incorporating more studies could reinforce this
argument.
5.Charts:Ensure that all chart legends are clear and descriptive, particularly for complex visual
data such as forest plots and meta-analyses. This will aid readers in accurately interpreting the
data.
Overall, this study offers valuable insights into the molecular mechanisms of gastric cancer and
provides a foundation for screening and intervention strategies using metabolites as potential
biomarkers. After addressing the suggested revisions, I believe the paper will be suitable for
publication. Therefore, I recommend it for publication pending comprehensive revision.
assistant