Title: The efficacy of non-anesthesiologist-administered propofol sedation with
a target- controlled infusion system during double-balloon endoscopic retrograde
cholangiopancreatography
Version: 2 Date: 09 Aug 2023
Reviewer's report:
The reviewer suggests the author change the term 'poor sedation' for the primary outcome. The
authors define poor sedation as the need for additional medication in addition to the pre-setted
protocol (propofol+TCI v.s. Diazepam). 'Poor sedation' may mislead the reader as the patient
was suffering during DB-ERCP; in contrast, it means the need for additional medication to keep
their sedation target (RSS 5-6. )
Page 11, paragraph 3, line 10:
The TCI utilizes patient parameters and controls the brain's propofol level of targeted drug
concentration. Could the TCI in the study monitor the blood concentration in real-time?
The author demonstrates the protocols of the diazepam and the propofol group in Figure 2
and Figure 3. Their process flow diagrams are not easy for readers to appreciate the sedation
processes. The reviewer suggests the author rearrange the flow chart for a more explicit
demonstration of their protocols.
Title: The efficacy of non-anesthesiologist-administered propofol sedation with
a target- controlled infusion system during double-balloon endoscopic retrograde
cholangiopancreatography
Version: 2 Date: 09 Aug 2023
Reviewer's report:
The reviewer suggests the author change the term 'poor sedation' for the primary outcome. The
authors define poor sedation as the need for additional medication in addition to the pre-setted
protocol (propofol+TCI v.s. Diazepam). 'Poor sedation' may mislead the reader as the patient
was suffering during DB-ERCP; in contrast, it means the need for additional medication to keep
their sedation target (RSS 5-6. )
Page 11, paragraph 3, line 10:
The TCI utilizes patient parameters and controls the brain's propofol level of targeted drug
concentration. Could the TCI in the study monitor the blood concentration in real-time?
The author demonstrates the protocols of the diazepam and the propofol group in Figure 2
and Figure 3. Their process flow diagrams are not easy for readers to appreciate the sedation
processes. The reviewer suggests the author rearrange the flow chart for a more explicit
demonstration of their protocols.
Please review this paper.
user
Title: The efficacy of non-anesthesiologist-administered propofol sedation with
a target- controlled infusion system during double-balloon endoscopic retrograde
cholangiopancreatography
Version: 2 Date: 09 Aug 2023
Reviewer's report:
The reviewer suggests the author change the term 'poor sedation' for the primary outcome. The
authors define poor sedation as the need for additional medication in addition to the pre-setted
protocol (propofol+TCI v.s. Diazepam). 'Poor sedation' may mislead the reader as the patient
was suffering during DB-ERCP; in contrast, it means the need for additional medication to keep
their sedation target (RSS 5-6. )
Page 11, paragraph 3, line 10:
The TCI utilizes patient parameters and controls the brain's propofol level of targeted drug
concentration. Could the TCI in the study monitor the blood concentration in real-time?
The author demonstrates the protocols of the diazepam and the propofol group in Figure 2
and Figure 3. Their process flow diagrams are not easy for readers to appreciate the sedation
processes. The reviewer suggests the author rearrange the flow chart for a more explicit
demonstration of their protocols.
assistant