Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 05 Oct 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a review of a manuscript titled "Human blood metabolites
and gastric cancer: a Mendelian Randomization Analysis". In this analysis, authors show that
the genetic components predisposing individuals to elevated levels of 3-methyl-2-oxovalerate
and piperine also predispose to gastric cancer, while the genetics underpinning elevation in the
levels of phenylalanylphenylalanine  prove protection against the development of this malignant
disease. Manuscript is well written. The only problem that noticeable  is that the Intro part is very
short. May be the part that describes previous metabolic studies of GC could be moved to Intro
section. Also, please consider abbreviating phenylalanylphenylalanine to Phe-Phe dipeptide or
likewise, to make respective parts of MS more readable. I see no problems with  statistical
analysis performed.
On a side note, please make sure that the text editing software uses English system of the word
breaking between lines. In current version of MS, each transferred word is broken in random
place, rather than by syllables, which makes the text hard to read.
REQUESTED REVISIONS:
Please see the note about expanding Introduction part of this MS and other small notes above.
Otherwise, all good
ADDITIONAL REQUESTS/SUGGESTIONS:
please see above. This is MS of excellent writing quality.
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 05 Oct 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a review of a manuscript titled "Human blood metabolites
and gastric cancer: a Mendelian Randomization Analysis". In this analysis, authors show that
the genetic components predisposing individuals to elevated levels of 3-methyl-2-oxovalerate
and piperine also predispose to gastric cancer, while the genetics underpinning elevation in the
levels of phenylalanylphenylalanine  prove protection against the development of this malignant
disease. Manuscript is well written. The only problem that noticeable  is that the Intro part is very
short. May be the part that describes previous metabolic studies of GC could be moved to Intro
section. Also, please consider abbreviating phenylalanylphenylalanine to Phe-Phe dipeptide or
likewise, to make respective parts of MS more readable. I see no problems with  statistical
analysis performed.
On a side note, please make sure that the text editing software uses English system of the word
breaking between lines. In current version of MS, each transferred word is broken in random
place, rather than by syllables, which makes the text hard to read.
REQUESTED REVISIONS:
Please see the note about expanding Introduction part of this MS and other small notes above.
Otherwise, all good
ADDITIONAL REQUESTS/SUGGESTIONS:
please see above. This is MS of excellent writing quality.
Please review this paper.
user
Title: Human blood metabolites and gastric cancer: a Mendelian Randomization Analysis
Version: 0 Date: 05 Oct 2024
Reviewer's report:
PEER REVIEWER ASSESSMENTS:
OBJECTIVE - Full research articles: is there a clear objective that addresses a testable research
question(s) (brief or other article types: is there a clear objective)?
Yes - there is a clear objective
DESIGN - Is the current approach (including controls and analysis protocols) appropriate for
the objective?
Yes - the approach is appropriate
EXECUTION - Are the experiments and analyses performed with technical rigor to allow
confidence in the results?
Yes - experiments and analyses were performed appropriately
STATISTICS - Is the use of statistics in the manuscript appropriate?
Yes - appropriate statistical analyses have been used in the study
INTERPRETATION - Is the current interpretation/discussion of the results reasonable and not
overstated?
No - there are minor issues
OVERALL MANUSCRIPT POTENTIAL - Is the current version of this work technically
sound? If not, can revisions be made to make the work technically sound?
Probably - with minor revisions
PEER REVIEWER COMMENTS:
GENERAL COMMENTS: This is a review of a manuscript titled "Human blood metabolites
and gastric cancer: a Mendelian Randomization Analysis". In this analysis, authors show that
the genetic components predisposing individuals to elevated levels of 3-methyl-2-oxovalerate
and piperine also predispose to gastric cancer, while the genetics underpinning elevation in the
levels of phenylalanylphenylalanine  prove protection against the development of this malignant
disease. Manuscript is well written. The only problem that noticeable  is that the Intro part is very
short. May be the part that describes previous metabolic studies of GC could be moved to Intro
section. Also, please consider abbreviating phenylalanylphenylalanine to Phe-Phe dipeptide or
likewise, to make respective parts of MS more readable. I see no problems with  statistical
analysis performed.
On a side note, please make sure that the text editing software uses English system of the word
breaking between lines. In current version of MS, each transferred word is broken in random
place, rather than by syllables, which makes the text hard to read.
REQUESTED REVISIONS:
Please see the note about expanding Introduction part of this MS and other small notes above.
Otherwise, all good
ADDITIONAL REQUESTS/SUGGESTIONS:
please see above. This is MS of excellent writing quality.
assistant