Title: Clinical significance and long-term prognosis of ulcerative colitis patients with
appendiceal orifice inflammation
Version: 1 Date: 15 Nov 2022
Reviewer's report:
The manuscript entitled ‘Clinical significance and long-term prognosis of ulcerative colitis
patients with appendiceal orifice inflammation‘ studies the role of AOI in patients with UC,
which is an important topic in this field. This article was interesting in trying to explain the
clinical course of UC patients with AOI. However, several questions arose while reading this
manuscript.
1. Mild disease activity at the diagnosis of UC was more included in patients with AOI than
others. Does it influence the long-term outcomes of patients with AOI compared to those without
AOI?
2. The patients with AOI were less included in the group treated with high-dose 5-ASA than
those without AOI (13.3% vs. 24.8%, P = 0.016). Does the treatment with high-dose 5-ASA
induce the occurrence of AOI, resulting in outcomes of them?
3. This study included patients with proximal involvement. How can you differentiate them from
patients with lesions responding to pharmacotherapy?
Title: Clinical significance and long-term prognosis of ulcerative colitis patients with
appendiceal orifice inflammation
Version: 1 Date: 15 Nov 2022
Reviewer's report:
The manuscript entitled ‘Clinical significance and long-term prognosis of ulcerative colitis
patients with appendiceal orifice inflammation‘ studies the role of AOI in patients with UC,
which is an important topic in this field. This article was interesting in trying to explain the
clinical course of UC patients with AOI. However, several questions arose while reading this
manuscript.
1. Mild disease activity at the diagnosis of UC was more included in patients with AOI than
others. Does it influence the long-term outcomes of patients with AOI compared to those without
AOI?
2. The patients with AOI were less included in the group treated with high-dose 5-ASA than
those without AOI (13.3% vs. 24.8%, P = 0.016). Does the treatment with high-dose 5-ASA
induce the occurrence of AOI, resulting in outcomes of them?
3. This study included patients with proximal involvement. How can you differentiate them from
patients with lesions responding to pharmacotherapy?
Please review this paper.
user
Title: Clinical significance and long-term prognosis of ulcerative colitis patients with
appendiceal orifice inflammation
Version: 1 Date: 15 Nov 2022
Reviewer's report:
The manuscript entitled ‘Clinical significance and long-term prognosis of ulcerative colitis
patients with appendiceal orifice inflammation‘ studies the role of AOI in patients with UC,
which is an important topic in this field. This article was interesting in trying to explain the
clinical course of UC patients with AOI. However, several questions arose while reading this
manuscript.
1. Mild disease activity at the diagnosis of UC was more included in patients with AOI than
others. Does it influence the long-term outcomes of patients with AOI compared to those without
AOI?
2. The patients with AOI were less included in the group treated with high-dose 5-ASA than
those without AOI (13.3% vs. 24.8%, P = 0.016). Does the treatment with high-dose 5-ASA
induce the occurrence of AOI, resulting in outcomes of them?
3. This study included patients with proximal involvement. How can you differentiate them from
patients with lesions responding to pharmacotherapy?
assistant