Title: Postoperative liver dysfunction is associated with poor long-term outcomes in patients
with colorectal cancer: a retrospective cohort study
Version: 0 Date: 10 Mar 2023
Reviewer's report:
This study found that L/S ratio on CT was strongly associated with postoperative liver
dysfunction,and postoperative liver dysfunction was associated with worse DFS after radical
surgery for colorectal cancer. Postoperative complications increase tumor recurrence rate and
reduce overall survival in patients with colorectal cancer.There may be some possible limitations
in this study.
1.The sample size of positive cases is relatively small, please increase the sample size to reduce
publication bias.
2.In this paper, CTCAE's diagnostic criteria was used as the main evaluation criteria for
liver dysfunction, and it is suggested that the detail of CTCAE should be explained in the
supplementary materials.
3.As stated in the discussion section, chronic inflammation of the liver affects the prognosis
of CRC#This study found the association between postoperative liver dysfunction and the L/S
ratio. so what is the innovation of this article? It is recommended to add other indicators of liver
status for comparative analysis.
4.This study excluded preoperative liver dysfunction, postoperative complications,
chemotherapy course and pathological grade, and finally concluded that postoperative liver
dysfunction was associated with the prognosis of colorectal cancer. However, liver function is
an indicator of liver status, is this equivalent to the relationship between liver reserve function
status and colorectal cancer prognosis? As mentioned in the paper, so are L/S ratio or liver
fibrosis also related to the prognosis of colorectal cancer?
Title: Postoperative liver dysfunction is associated with poor long-term outcomes in patients
with colorectal cancer: a retrospective cohort study
Version: 0 Date: 10 Mar 2023
Reviewer's report:
This study found that L/S ratio on CT was strongly associated with postoperative liver
dysfunction,and postoperative liver dysfunction was associated with worse DFS after radical
surgery for colorectal cancer. Postoperative complications increase tumor recurrence rate and
reduce overall survival in patients with colorectal cancer.There may be some possible limitations
in this study.
1.The sample size of positive cases is relatively small, please increase the sample size to reduce
publication bias.
2.In this paper, CTCAE's diagnostic criteria was used as the main evaluation criteria for
liver dysfunction, and it is suggested that the detail of CTCAE should be explained in the
supplementary materials.
3.As stated in the discussion section, chronic inflammation of the liver affects the prognosis
of CRC#This study found the association between postoperative liver dysfunction and the L/S
ratio. so what is the innovation of this article? It is recommended to add other indicators of liver
status for comparative analysis.
4.This study excluded preoperative liver dysfunction, postoperative complications,
chemotherapy course and pathological grade, and finally concluded that postoperative liver
dysfunction was associated with the prognosis of colorectal cancer. However, liver function is
an indicator of liver status, is this equivalent to the relationship between liver reserve function
status and colorectal cancer prognosis? As mentioned in the paper, so are L/S ratio or liver
fibrosis also related to the prognosis of colorectal cancer?
Please review this paper.
user
Title: Postoperative liver dysfunction is associated with poor long-term outcomes in patients
with colorectal cancer: a retrospective cohort study
Version: 0 Date: 10 Mar 2023
Reviewer's report:
This study found that L/S ratio on CT was strongly associated with postoperative liver
dysfunction,and postoperative liver dysfunction was associated with worse DFS after radical
surgery for colorectal cancer. Postoperative complications increase tumor recurrence rate and
reduce overall survival in patients with colorectal cancer.There may be some possible limitations
in this study.
1.The sample size of positive cases is relatively small, please increase the sample size to reduce
publication bias.
2.In this paper, CTCAE's diagnostic criteria was used as the main evaluation criteria for
liver dysfunction, and it is suggested that the detail of CTCAE should be explained in the
supplementary materials.
3.As stated in the discussion section, chronic inflammation of the liver affects the prognosis
of CRC#This study found the association between postoperative liver dysfunction and the L/S
ratio. so what is the innovation of this article? It is recommended to add other indicators of liver
status for comparative analysis.
4.This study excluded preoperative liver dysfunction, postoperative complications,
chemotherapy course and pathological grade, and finally concluded that postoperative liver
dysfunction was associated with the prognosis of colorectal cancer. However, liver function is
an indicator of liver status, is this equivalent to the relationship between liver reserve function
status and colorectal cancer prognosis? As mentioned in the paper, so are L/S ratio or liver
fibrosis also related to the prognosis of colorectal cancer?
assistant