Reviewer's report
Title:Hepatoprotective role of liver fatty acid binding protein in acetaminophen
induced toxicity
Version:3Date:20 February 2014
Reviewer: Hartmut Jaeschke
Reviewer's report:
The authors addressed the comments and the manuscript has improved. I am
still concerned about the interpretation of a minor increase in Bax protein
expression as evidence for apoptotic cell death. The increase in Bax protein
levels shows a similar response to APAP overdose as seen in mouse
hepatocytes during necrosis. However, this is not a parameter for apoptotic cell
death. The authors are encouraged to correct this mistake.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No competing interests.
Reviewer's report
Title:Hepatoprotective role of liver fatty acid binding protein in acetaminophen
induced toxicity
Version:3Date:20 February 2014
Reviewer: Hartmut Jaeschke
Reviewer's report:
The authors addressed the comments and the manuscript has improved. I am
still concerned about the interpretation of a minor increase in Bax protein
expression as evidence for apoptotic cell death. The increase in Bax protein
levels shows a similar response to APAP overdose as seen in mouse
hepatocytes during necrosis. However, this is not a parameter for apoptotic cell
death. The authors are encouraged to correct this mistake.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No competing interests.
Please review this paper.
user
Reviewer's report
Title:Hepatoprotective role of liver fatty acid binding protein in acetaminophen
induced toxicity
Version:3Date:20 February 2014
Reviewer: Hartmut Jaeschke
Reviewer's report:
The authors addressed the comments and the manuscript has improved. I am
still concerned about the interpretation of a minor increase in Bax protein
expression as evidence for apoptotic cell death. The increase in Bax protein
levels shows a similar response to APAP overdose as seen in mouse
hepatocytes during necrosis. However, this is not a parameter for apoptotic cell
death. The authors are encouraged to correct this mistake.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
No competing interests.
assistant