Title: A novel endoplasmic reticulum stress-related lncRNA signature for prognosis prediction
and immune response evaluation in Stomach adenocarcinoma
Version: 0 Date: 17 Sep 2023
Reviewer's report:
The authors established 9 ERS related-lncRNAs through bioinformatics to evaluate the
prognosis, immune microenvironment and provide potential treatment guidance for STAD
patients. I believe this study has potential significance for STAD patients.
Comments:
1. Why are there such big differences between the AUCs of Fig4E and Fig4F in predicting OS
in 1, 3 and 5 years? How does the author view this issue?
2. In Fig7C and D, only those with statistical significance can be called significant differences.
Please re-describe the results of these two figures.
3. The author's discussion of TMB and TIME lacks a certain depth. The authors should provide
an in-depth discussion of the tumour immune microenvironment and TMB, drawing on the
following literature: PMID: 36122795; PMID: 37414962; PMID: 36367669; PMID: 34262855;
PMID: 31406485.
Title: A novel endoplasmic reticulum stress-related lncRNA signature for prognosis prediction
and immune response evaluation in Stomach adenocarcinoma
Version: 0 Date: 17 Sep 2023
Reviewer's report:
The authors established 9 ERS related-lncRNAs through bioinformatics to evaluate the
prognosis, immune microenvironment and provide potential treatment guidance for STAD
patients. I believe this study has potential significance for STAD patients.
Comments:
1. Why are there such big differences between the AUCs of Fig4E and Fig4F in predicting OS
in 1, 3 and 5 years? How does the author view this issue?
2. In Fig7C and D, only those with statistical significance can be called significant differences.
Please re-describe the results of these two figures.
3. The author's discussion of TMB and TIME lacks a certain depth. The authors should provide
an in-depth discussion of the tumour immune microenvironment and TMB, drawing on the
following literature: PMID: 36122795; PMID: 37414962; PMID: 36367669; PMID: 34262855;
PMID: 31406485.
Please review this paper.
user
Title: A novel endoplasmic reticulum stress-related lncRNA signature for prognosis prediction
and immune response evaluation in Stomach adenocarcinoma
Version: 0 Date: 17 Sep 2023
Reviewer's report:
The authors established 9 ERS related-lncRNAs through bioinformatics to evaluate the
prognosis, immune microenvironment and provide potential treatment guidance for STAD
patients. I believe this study has potential significance for STAD patients.
Comments:
1. Why are there such big differences between the AUCs of Fig4E and Fig4F in predicting OS
in 1, 3 and 5 years? How does the author view this issue?
2. In Fig7C and D, only those with statistical significance can be called significant differences.
Please re-describe the results of these two figures.
3. The author's discussion of TMB and TIME lacks a certain depth. The authors should provide
an in-depth discussion of the tumour immune microenvironment and TMB, drawing on the
following literature: PMID: 36122795; PMID: 37414962; PMID: 36367669; PMID: 34262855;
PMID: 31406485.
assistant