Title: Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-
induced pathology in mice
Version: 3 Date: 28 Mar 2021
Reviewer's report:
The study is well designed in.The claims have proved that selectively inhibiting solTNF using
XPro1595 improved the pathophysiological and neurological sequelae of cerulein-induced
pancreatitis in mice. This study demonstrates that XPro1595 may be useful in relieving the
inflammation and pain of acute pancreatitis.The statistical methods used in this study are
correct.The results of the study were in line with the expectations of our research team.This
study is somewhat innovative and there are no similar studies available.There are of course some
limitations to the study and the effect of XPro1595 injection on changes in the expression of the
various isoforms of TNF# caused by acute pancreatitis should be tested.
Title: Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-
induced pathology in mice
Version: 3 Date: 28 Mar 2021
Reviewer's report:
The study is well designed in.The claims have proved that selectively inhibiting solTNF using
XPro1595 improved the pathophysiological and neurological sequelae of cerulein-induced
pancreatitis in mice. This study demonstrates that XPro1595 may be useful in relieving the
inflammation and pain of acute pancreatitis.The statistical methods used in this study are
correct.The results of the study were in line with the expectations of our research team.This
study is somewhat innovative and there are no similar studies available.There are of course some
limitations to the study and the effect of XPro1595 injection on changes in the expression of the
various isoforms of TNF# caused by acute pancreatitis should be tested.
Please review this paper.
user
Title: Selective inhibition of soluble TNF using XPro1595 relieves pain and attenuates cerulein-
induced pathology in mice
Version: 3 Date: 28 Mar 2021
Reviewer's report:
The study is well designed in.The claims have proved that selectively inhibiting solTNF using
XPro1595 improved the pathophysiological and neurological sequelae of cerulein-induced
pancreatitis in mice. This study demonstrates that XPro1595 may be useful in relieving the
inflammation and pain of acute pancreatitis.The statistical methods used in this study are
correct.The results of the study were in line with the expectations of our research team.This
study is somewhat innovative and there are no similar studies available.There are of course some
limitations to the study and the effect of XPro1595 injection on changes in the expression of the
various isoforms of TNF# caused by acute pancreatitis should be tested.
assistant