Reviewer's report
Title:Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor
pylori seropositivity, gastric atrophy and gastric cancer in Japanese
Version: 3Date:29 December 2008
Reviewer: Haruhiko Sugimura
Reviewer's report:
The responses well explains the assumptions they took for the interpretation of
their data.
They bluntly state, all the Japanese gastric cancer is related to HP infection, and
HP seronegative atrophy is also a consequence of burned out infection. The
hypothesis require validation. There are may be quite a few factors including
genetic ones to make the individual stomach for stable HP colonization, given
endemic access occasions to HP for every Japanese granted (Short mucin 1
alleles are associated with low virulent H pylori strains infection. Peleteiro B,
Lunet N, Santos-Silva F, David L, Figueiredo C, Barros H. World J Gastroenterol.
2007 Mar 28;13(12):1885-6, Natural antibiotic function of a human gastric mucin
against Helicobacter pylori infection. Kawakubo M, Ito Y, Okimura Y, Kobayashi
M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J.
Science. 2004 Aug 13;305(5686):1003-6.) and they may confound or cancel the
effect of this polymorphism, if there are any.
Their hypothesis and its limitation should be included.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor
pylori seropositivity, gastric atrophy and gastric cancer in Japanese
Version: 3Date:29 December 2008
Reviewer: Haruhiko Sugimura
Reviewer's report:
The responses well explains the assumptions they took for the interpretation of
their data.
They bluntly state, all the Japanese gastric cancer is related to HP infection, and
HP seronegative atrophy is also a consequence of burned out infection. The
hypothesis require validation. There are may be quite a few factors including
genetic ones to make the individual stomach for stable HP colonization, given
endemic access occasions to HP for every Japanese granted (Short mucin 1
alleles are associated with low virulent H pylori strains infection. Peleteiro B,
Lunet N, Santos-Silva F, David L, Figueiredo C, Barros H. World J Gastroenterol.
2007 Mar 28;13(12):1885-6, Natural antibiotic function of a human gastric mucin
against Helicobacter pylori infection. Kawakubo M, Ito Y, Okimura Y, Kobayashi
M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J.
Science. 2004 Aug 13;305(5686):1003-6.) and they may confound or cancel the
effect of this polymorphism, if there are any.
Their hypothesis and its limitation should be included.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Associations of a PTPN11 G/A polymorphism at intron 3 with Helicobactor
pylori seropositivity, gastric atrophy and gastric cancer in Japanese
Version: 3Date:29 December 2008
Reviewer: Haruhiko Sugimura
Reviewer's report:
The responses well explains the assumptions they took for the interpretation of
their data.
They bluntly state, all the Japanese gastric cancer is related to HP infection, and
HP seronegative atrophy is also a consequence of burned out infection. The
hypothesis require validation. There are may be quite a few factors including
genetic ones to make the individual stomach for stable HP colonization, given
endemic access occasions to HP for every Japanese granted (Short mucin 1
alleles are associated with low virulent H pylori strains infection. Peleteiro B,
Lunet N, Santos-Silva F, David L, Figueiredo C, Barros H. World J Gastroenterol.
2007 Mar 28;13(12):1885-6, Natural antibiotic function of a human gastric mucin
against Helicobacter pylori infection. Kawakubo M, Ito Y, Okimura Y, Kobayashi
M, Sakura K, Kasama S, Fukuda MN, Fukuda M, Katsuyama T, Nakayama J.
Science. 2004 Aug 13;305(5686):1003-6.) and they may confound or cancel the
effect of this polymorphism, if there are any.
Their hypothesis and its limitation should be included.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests
assistant