Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 2 Date: 13 Sep 2023
Reviewer's report:
The authors applied the "trial emulation" that accounted for measured differences between
treatment arms, and worked hard to prevent possible confounders. They concluded that
statins may have chemo-preventive effect for patients with chronic hepatitis B (CHB) with
dyslipidemia. Though the cut-off level of cholesterol and the timing of different statins
application need further investigation, the research may change the daily practice for CHB
patients.
Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 2 Date: 13 Sep 2023
Reviewer's report:
The authors applied the "trial emulation" that accounted for measured differences between
treatment arms, and worked hard to prevent possible confounders. They concluded that
statins may have chemo-preventive effect for patients with chronic hepatitis B (CHB) with
dyslipidemia. Though the cut-off level of cholesterol and the timing of different statins
application need further investigation, the research may change the daily practice for CHB
patients.
Please review this paper.
user
Title: Statin Use and the Risk of Hepatocellular Carcinoma Among Patients With Chronic
Hepatitis B: An Emulated Target Trial Using Longitudinal Nationwide Population Cohort Data
Version: 2 Date: 13 Sep 2023
Reviewer's report:
The authors applied the "trial emulation" that accounted for measured differences between
treatment arms, and worked hard to prevent possible confounders. They concluded that
statins may have chemo-preventive effect for patients with chronic hepatitis B (CHB) with
dyslipidemia. Though the cut-off level of cholesterol and the timing of different statins
application need further investigation, the research may change the daily practice for CHB
patients.
assistant