Title: Expression of Unfolded Protein Response Genes in Post-transplantation Liver Biopsies
Version: 1 Date: 13 Jun 2022
Reviewer's report:
This is a succinct study to examine transcriptome data generated from liver biopsy samples to
provide a link between human hepatic UPR gene expression and human cholestasis. The authors
found that CYP7A1 was increased along with an enrichment of the UPR pathway. The authors
also performed correlation analysis with serum patient information and their findings.  This is
a very well executed study with only a few minor suggestions.
author comments:
was there any correlation between CYP7A1 and serum chemistries?
similarly, since there was a correlation with FGF, did the authors look at FXR correlations?
why do the authors speculate that the ALP did not correlate with the UPR genes - were ALP
levels correlated with any of the examined markers?
Title: Expression of Unfolded Protein Response Genes in Post-transplantation Liver Biopsies
Version: 1 Date: 13 Jun 2022
Reviewer's report:
This is a succinct study to examine transcriptome data generated from liver biopsy samples to
provide a link between human hepatic UPR gene expression and human cholestasis. The authors
found that CYP7A1 was increased along with an enrichment of the UPR pathway. The authors
also performed correlation analysis with serum patient information and their findings.  This is
a very well executed study with only a few minor suggestions.
author comments:
was there any correlation between CYP7A1 and serum chemistries?
similarly, since there was a correlation with FGF, did the authors look at FXR correlations?
why do the authors speculate that the ALP did not correlate with the UPR genes - were ALP
levels correlated with any of the examined markers?
Please review this paper.
user
Title: Expression of Unfolded Protein Response Genes in Post-transplantation Liver Biopsies
Version: 1 Date: 13 Jun 2022
Reviewer's report:
This is a succinct study to examine transcriptome data generated from liver biopsy samples to
provide a link between human hepatic UPR gene expression and human cholestasis. The authors
found that CYP7A1 was increased along with an enrichment of the UPR pathway. The authors
also performed correlation analysis with serum patient information and their findings.  This is
a very well executed study with only a few minor suggestions.
author comments:
was there any correlation between CYP7A1 and serum chemistries?
similarly, since there was a correlation with FGF, did the authors look at FXR correlations?
why do the authors speculate that the ALP did not correlate with the UPR genes - were ALP
levels correlated with any of the examined markers?
assistant