Title: Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors
Version: 3 Date: 09 Apr 2021
Reviewer:  Muinah Adenike Fowora
Reviewer's report:
This is an interesting study to add to the existing body knowledge on the factors that influence
H. pylori infection in patients with gastroduodenal disorders. The gap in information in the local
context of Iran makes this article adequate.
The following needs to be addressed in the study.
1. The methodology is insufficient to allow the study to be repeated in other areas.
The study design was not correctly mentioned. The authors wrote, "This study was conducted
as a questionnaire". The study, however, used a cross-sectional study design.
2. Pathology may not be sufficient to screen the patients for H. pylori infection. A brief
description of the pathological method used should be provided as well as the criteria for
positivity. I will recommend the use of direct detection of H. pylori from the collected biopsy
using molecular methods or serological methods.
3. The researchers used only descriptive statistics and chi-square analysis for their statistical
analysis. Considering that multiple variables were collected with the questionnaire. A chi-square
analysis may not be sufficient to analyze this data. They should consider using a multiple logistic
regression model.
4. There are several typographical and writing issues with the manuscript. I suggest the authors
used a writing editor to address this problem
Title: Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors
Version: 3 Date: 09 Apr 2021
Reviewer:  Muinah Adenike Fowora
Reviewer's report:
This is an interesting study to add to the existing body knowledge on the factors that influence
H. pylori infection in patients with gastroduodenal disorders. The gap in information in the local
context of Iran makes this article adequate.
The following needs to be addressed in the study.
1. The methodology is insufficient to allow the study to be repeated in other areas.
The study design was not correctly mentioned. The authors wrote, "This study was conducted
as a questionnaire". The study, however, used a cross-sectional study design.
2. Pathology may not be sufficient to screen the patients for H. pylori infection. A brief
description of the pathological method used should be provided as well as the criteria for
positivity. I will recommend the use of direct detection of H. pylori from the collected biopsy
using molecular methods or serological methods.
3. The researchers used only descriptive statistics and chi-square analysis for their statistical
analysis. Considering that multiple variables were collected with the questionnaire. A chi-square
analysis may not be sufficient to analyze this data. They should consider using a multiple logistic
regression model.
4. There are several typographical and writing issues with the manuscript. I suggest the authors
used a writing editor to address this problem
Please review this paper.
user
Title: Helicobacter pylori infection in Iran: demographic, endoscopic and pathological factors
Version: 3 Date: 09 Apr 2021
Reviewer:  Muinah Adenike Fowora
Reviewer's report:
This is an interesting study to add to the existing body knowledge on the factors that influence
H. pylori infection in patients with gastroduodenal disorders. The gap in information in the local
context of Iran makes this article adequate.
The following needs to be addressed in the study.
1. The methodology is insufficient to allow the study to be repeated in other areas.
The study design was not correctly mentioned. The authors wrote, "This study was conducted
as a questionnaire". The study, however, used a cross-sectional study design.
2. Pathology may not be sufficient to screen the patients for H. pylori infection. A brief
description of the pathological method used should be provided as well as the criteria for
positivity. I will recommend the use of direct detection of H. pylori from the collected biopsy
using molecular methods or serological methods.
3. The researchers used only descriptive statistics and chi-square analysis for their statistical
analysis. Considering that multiple variables were collected with the questionnaire. A chi-square
analysis may not be sufficient to analyze this data. They should consider using a multiple logistic
regression model.
4. There are several typographical and writing issues with the manuscript. I suggest the authors
used a writing editor to address this problem
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