Title: Choledocholithiasis as a risk factor for cholangiocarcinoma: a nationwide retrospective
cohort study
Version: 1 Date: 19 Dec 2024
Reviewer's report:
-How do we know in the study that increased association between cholangiocarcinoma and
choledocholithiasis is a true association and not confounded by the age. as the association is
noted higher with older population.?
- Do we have information about what was done in the patient with choledocholithiasis or if they
were symptomatic. Any intervention was done for the diagnosis. It might be meaningful if an
acutal long term inflammation actually has an association with the cholangiocarcinoma
Title: Choledocholithiasis as a risk factor for cholangiocarcinoma: a nationwide retrospective
cohort study
Version: 1 Date: 19 Dec 2024
Reviewer's report:
-How do we know in the study that increased association between cholangiocarcinoma and
choledocholithiasis is a true association and not confounded by the age. as the association is
noted higher with older population.?
- Do we have information about what was done in the patient with choledocholithiasis or if they
were symptomatic. Any intervention was done for the diagnosis. It might be meaningful if an
acutal long term inflammation actually has an association with the cholangiocarcinoma
Please review this paper.
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Title: Choledocholithiasis as a risk factor for cholangiocarcinoma: a nationwide retrospective
cohort study
Version: 1 Date: 19 Dec 2024
Reviewer's report:
-How do we know in the study that increased association between cholangiocarcinoma and
choledocholithiasis is a true association and not confounded by the age. as the association is
noted higher with older population.?
- Do we have information about what was done in the patient with choledocholithiasis or if they
were symptomatic. Any intervention was done for the diagnosis. It might be meaningful if an
acutal long term inflammation actually has an association with the cholangiocarcinoma
assistant