Title: NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot
tumor microenvironment in hepatocellular carcinoma
Version: 1 Date: 12 May 2022
Reviewer's report:
The authors utilized several public datasets and bioinformatics tools to explore the expression
pattern and biological functions of NAPSB in HCC and found NAPSB was downregulated
in HCC, and high NAPSB expression correlated with improved survival outcome, immune
activation, immunomodulators, tumor-infiltrating immune cells (TIICs), T cell inflamed score,
sensitivity to immunotherapy and chemotherapy, tumor cell death. This study is well designed
and the findings are interesting. However it is bioinformatics analysis study and it would be very
nice if these finding can be validated further in own cohort.
Title: NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot
tumor microenvironment in hepatocellular carcinoma
Version: 1 Date: 12 May 2022
Reviewer's report:
The authors utilized several public datasets and bioinformatics tools to explore the expression
pattern and biological functions of NAPSB in HCC and found NAPSB was downregulated
in HCC, and high NAPSB expression correlated with improved survival outcome, immune
activation, immunomodulators, tumor-infiltrating immune cells (TIICs), T cell inflamed score,
sensitivity to immunotherapy and chemotherapy, tumor cell death. This study is well designed
and the findings are interesting. However it is bioinformatics analysis study and it would be very
nice if these finding can be validated further in own cohort.
Please review this paper.
user
Title: NAPSB as a predictive marker for prognosis and therapy associated with an immuno-hot
tumor microenvironment in hepatocellular carcinoma
Version: 1 Date: 12 May 2022
Reviewer's report:
The authors utilized several public datasets and bioinformatics tools to explore the expression
pattern and biological functions of NAPSB in HCC and found NAPSB was downregulated
in HCC, and high NAPSB expression correlated with improved survival outcome, immune
activation, immunomodulators, tumor-infiltrating immune cells (TIICs), T cell inflamed score,
sensitivity to immunotherapy and chemotherapy, tumor cell death. This study is well designed
and the findings are interesting. However it is bioinformatics analysis study and it would be very
nice if these finding can be validated further in own cohort.
assistant