Title: Role of Colectomy in the Management of Appendiceal Tumors: A Retrospective Cohort
Study
Version: 2 Date: 02 Sep 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
Thank you for allowing me to review this attractive article. This retrospective study presented
evidence of surgical procedures for appendiceal tumors in the US cohort. The study found that
the incidence and rate of RHC for NEN decreased. In the National Cancer Database, RHC
was significantly associated with increased survival versus appendectomy for stage 2 disease
of all tumor types and stage 1 non-mucinous adenocarcinoma. It is an interesting real-world-
based study and worth publishing. However, there are some concerns about this article. 1. In
this cohort, are there cases of RHC following appendectomy according to the histopathological
results? In our experiences, we found the incidence of Stage 4 is more common in appendiceal
tumors than Stage 2, as seen in conventional colon cancer. For this reason, this evidence may
not be helpful in other countries’ comfort. I humbly request to discuss these issues. 2. The
authors recommended presenting the flow diagram of patient inclusion. 3. It seems unbelievable
to decrease the incidence of NEN in this cohort. The authors should discuss how to decrease the
incidence of NEN in their cohort. 4. The authors are recommended to present this geographical
disparity as an atlas of maps of the US. The authors could discuss the differences in their
evidence between Oriental and Oceania countries. 5. They did not discuss how to diagnose
appendiceal tumors (e.g., coloscopy, CT, or after surgery).6. The authors present the outcomes
in the statistical analysis. They should present primary and secondary outcomes in the method
section.
Title: Role of Colectomy in the Management of Appendiceal Tumors: A Retrospective Cohort
Study
Version: 2 Date: 02 Sep 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
Thank you for allowing me to review this attractive article. This retrospective study presented
evidence of surgical procedures for appendiceal tumors in the US cohort. The study found that
the incidence and rate of RHC for NEN decreased. In the National Cancer Database, RHC
was significantly associated with increased survival versus appendectomy for stage 2 disease
of all tumor types and stage 1 non-mucinous adenocarcinoma. It is an interesting real-world-
based study and worth publishing. However, there are some concerns about this article. 1. In
this cohort, are there cases of RHC following appendectomy according to the histopathological
results? In our experiences, we found the incidence of Stage 4 is more common in appendiceal
tumors than Stage 2, as seen in conventional colon cancer. For this reason, this evidence may
not be helpful in other countries’ comfort. I humbly request to discuss these issues. 2. The
authors recommended presenting the flow diagram of patient inclusion. 3. It seems unbelievable
to decrease the incidence of NEN in this cohort. The authors should discuss how to decrease the
incidence of NEN in their cohort. 4. The authors are recommended to present this geographical
disparity as an atlas of maps of the US. The authors could discuss the differences in their
evidence between Oriental and Oceania countries. 5. They did not discuss how to diagnose
appendiceal tumors (e.g., coloscopy, CT, or after surgery).6. The authors present the outcomes
in the statistical analysis. They should present primary and secondary outcomes in the method
section.
Please review this paper.
user
Title: Role of Colectomy in the Management of Appendiceal Tumors: A Retrospective Cohort
Study
Version: 2 Date: 02 Sep 2023
Reviewer:  Konosuke Nakaji
Reviewer's report:
Thank you for allowing me to review this attractive article. This retrospective study presented
evidence of surgical procedures for appendiceal tumors in the US cohort. The study found that
the incidence and rate of RHC for NEN decreased. In the National Cancer Database, RHC
was significantly associated with increased survival versus appendectomy for stage 2 disease
of all tumor types and stage 1 non-mucinous adenocarcinoma. It is an interesting real-world-
based study and worth publishing. However, there are some concerns about this article. 1. In
this cohort, are there cases of RHC following appendectomy according to the histopathological
results? In our experiences, we found the incidence of Stage 4 is more common in appendiceal
tumors than Stage 2, as seen in conventional colon cancer. For this reason, this evidence may
not be helpful in other countries’ comfort. I humbly request to discuss these issues. 2. The
authors recommended presenting the flow diagram of patient inclusion. 3. It seems unbelievable
to decrease the incidence of NEN in this cohort. The authors should discuss how to decrease the
incidence of NEN in their cohort. 4. The authors are recommended to present this geographical
disparity as an atlas of maps of the US. The authors could discuss the differences in their
evidence between Oriental and Oceania countries. 5. They did not discuss how to diagnose
appendiceal tumors (e.g., coloscopy, CT, or after surgery).6. The authors present the outcomes
in the statistical analysis. They should present primary and secondary outcomes in the method
section.
assistant