Title: Significance and Clinical Utility of Targeted Metabolomic Analysis of Serum Bile Acid
Profiles for Early Diagnosis of Patients with Acute Pancreatitis
Version: 1 Date: 27 Nov 2024
Reviewer's report:
In this paper, Chunliang Guo, Wen Yong et al. found that some BAs were significantly
dysregulated in acute pancreatitis, and were associated with clinical parameters. The
dysregulation of BAs (TCA, TCDCA, TDCA, GCA) might be useful for the early diagnosis of
acute pancreatitis, especially for MSAP and SAP. It is a simple story, but the following points
should be concerned seriously.
1. In Figure 3, the differences between groups were not labelled.
2. The AUCs shown in Figure 6 were not consistent with the numbers described in the
manuscript.
3. The diagnostic performance of TCA is great, but that of other indicators (TCDCA, TDCA
and GCA) is not as good as TCA.
4. How about the diagnostic performance of AMS, LPS and other clinical parameters? In my
opinion, the diagnostic value of AMS and LPS might be much greater than TCA and other BAs.
5. The number of clinical cases were too small to draw a conclusion.
Title: Significance and Clinical Utility of Targeted Metabolomic Analysis of Serum Bile Acid
Profiles for Early Diagnosis of Patients with Acute Pancreatitis
Version: 1 Date: 27 Nov 2024
Reviewer's report:
In this paper, Chunliang Guo, Wen Yong et al. found that some BAs were significantly
dysregulated in acute pancreatitis, and were associated with clinical parameters. The
dysregulation of BAs (TCA, TCDCA, TDCA, GCA) might be useful for the early diagnosis of
acute pancreatitis, especially for MSAP and SAP. It is a simple story, but the following points
should be concerned seriously.
1. In Figure 3, the differences between groups were not labelled.
2. The AUCs shown in Figure 6 were not consistent with the numbers described in the
manuscript.
3. The diagnostic performance of TCA is great, but that of other indicators (TCDCA, TDCA
and GCA) is not as good as TCA.
4. How about the diagnostic performance of AMS, LPS and other clinical parameters? In my
opinion, the diagnostic value of AMS and LPS might be much greater than TCA and other BAs.
5. The number of clinical cases were too small to draw a conclusion.
Please review this paper.
user
Title: Significance and Clinical Utility of Targeted Metabolomic Analysis of Serum Bile Acid
Profiles for Early Diagnosis of Patients with Acute Pancreatitis
Version: 1 Date: 27 Nov 2024
Reviewer's report:
In this paper, Chunliang Guo, Wen Yong et al. found that some BAs were significantly
dysregulated in acute pancreatitis, and were associated with clinical parameters. The
dysregulation of BAs (TCA, TCDCA, TDCA, GCA) might be useful for the early diagnosis of
acute pancreatitis, especially for MSAP and SAP. It is a simple story, but the following points
should be concerned seriously.
1. In Figure 3, the differences between groups were not labelled.
2. The AUCs shown in Figure 6 were not consistent with the numbers described in the
manuscript.
3. The diagnostic performance of TCA is great, but that of other indicators (TCDCA, TDCA
and GCA) is not as good as TCA.
4. How about the diagnostic performance of AMS, LPS and other clinical parameters? In my
opinion, the diagnostic value of AMS and LPS might be much greater than TCA and other BAs.
5. The number of clinical cases were too small to draw a conclusion.
assistant