Title: Sex differences in Helicobacter pylori infection and recurrence rate among 81,754
Chinese adults: A cross-sectional study
Version: 2 Date: 05 Jul 2024
Reviewer's report:
General:
In this study, the authors investigated the sex differences of H. pylori infection rate and 1-year
recurrence rate in Chinese population. Authors showed a positive correlation between H. pylori
infection and age increase in women. This study was well written and may have potential.
Major comments:
1. Because there are many typos, so the manuscript needs to be carefully corrected.
2. Why did risk of H. pylori infection in female differ among generations?
3. The 1-year overall recurrence rate was 3.86%, including 2.82% in males and 5.44% in females.
This rate was too high compared with previous reports. What was the possibility of a false
negative when performing a successful or unsuccessful eradication therapy?
4. Is it common in China to use a urea breath test to diagnose H. pylori infection at health
checkups?
5. Please add information of an UBT kit used.
6. How do you deal with patients who have been examined more than once during the study
period?
7. Please calculate factors involved in re-infection in univariate and multivariate analyses.
8. Very few patients of H. pylori infection diagnosis were performed after one year. Selection
bias is also possible.
9. What causes differences in nutritional markers between with or without H. pylori infection?
10. How did you treat with patients failed eradication therapy?
11. P9: The reason why HP infection rates increase with age is unclear. Correctly, the reasons
why H. pylori infection rates decrease in younger generation is unclear.
12. Is the same result with the reports by Chinese researchers on H. pylori infection rates between
men and women?
Title: Sex differences in Helicobacter pylori infection and recurrence rate among 81,754
Chinese adults: A cross-sectional study
Version: 2 Date: 05 Jul 2024
Reviewer's report:
General:
In this study, the authors investigated the sex differences of H. pylori infection rate and 1-year
recurrence rate in Chinese population. Authors showed a positive correlation between H. pylori
infection and age increase in women. This study was well written and may have potential.
Major comments:
1. Because there are many typos, so the manuscript needs to be carefully corrected.
2. Why did risk of H. pylori infection in female differ among generations?
3. The 1-year overall recurrence rate was 3.86%, including 2.82% in males and 5.44% in females.
This rate was too high compared with previous reports. What was the possibility of a false
negative when performing a successful or unsuccessful eradication therapy?
4. Is it common in China to use a urea breath test to diagnose H. pylori infection at health
checkups?
5. Please add information of an UBT kit used.
6. How do you deal with patients who have been examined more than once during the study
period?
7. Please calculate factors involved in re-infection in univariate and multivariate analyses.
8. Very few patients of H. pylori infection diagnosis were performed after one year. Selection
bias is also possible.
9. What causes differences in nutritional markers between with or without H. pylori infection?
10. How did you treat with patients failed eradication therapy?
11. P9: The reason why HP infection rates increase with age is unclear. Correctly, the reasons
why H. pylori infection rates decrease in younger generation is unclear.
12. Is the same result with the reports by Chinese researchers on H. pylori infection rates between
men and women?
Please review this paper.
user
Title: Sex differences in Helicobacter pylori infection and recurrence rate among 81,754
Chinese adults: A cross-sectional study
Version: 2 Date: 05 Jul 2024
Reviewer's report:
General:
In this study, the authors investigated the sex differences of H. pylori infection rate and 1-year
recurrence rate in Chinese population. Authors showed a positive correlation between H. pylori
infection and age increase in women. This study was well written and may have potential.
Major comments:
1. Because there are many typos, so the manuscript needs to be carefully corrected.
2. Why did risk of H. pylori infection in female differ among generations?
3. The 1-year overall recurrence rate was 3.86%, including 2.82% in males and 5.44% in females.
This rate was too high compared with previous reports. What was the possibility of a false
negative when performing a successful or unsuccessful eradication therapy?
4. Is it common in China to use a urea breath test to diagnose H. pylori infection at health
checkups?
5. Please add information of an UBT kit used.
6. How do you deal with patients who have been examined more than once during the study
period?
7. Please calculate factors involved in re-infection in univariate and multivariate analyses.
8. Very few patients of H. pylori infection diagnosis were performed after one year. Selection
bias is also possible.
9. What causes differences in nutritional markers between with or without H. pylori infection?
10. How did you treat with patients failed eradication therapy?
11. P9: The reason why HP infection rates increase with age is unclear. Correctly, the reasons
why H. pylori infection rates decrease in younger generation is unclear.
12. Is the same result with the reports by Chinese researchers on H. pylori infection rates between
men and women?
assistant