Reviewer's report
Title:Multi-susceptibility genes associated with esophageal squamous cell
cancer risk and their potential use to identify subjects at high risk
Version: 1Date:22 March 2011
Reviewer: Elias Zintzaras
Reviewer's report:
For each variant, calculate the unadjusted and adjusted OR for the allele contrast
(only unadjusted), dominant, recessive, additive and co-dominant models (See
Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent
gene-disease associations requires appropriate methodological and statistical
approaches. J Clin Epidemiol. 2008 Jul;61(7):634-45).
An additional analysis based on the generalized odds ratio (ORG) should be
performed (see Zintzaras E. The generalized odds ratio as a measure of genetic
risk effect in the analysis and meta-analysis of association studies. Stat Appl
Genet Mol Biol. 2010;9(1):Article21) The ORG utilizes the complete genotype
distribution and provides an estimate of the magnitude of the association
between disease status (disease vs. healthy or disease progression) and
genotype (biallelic or multiallelic). So, apply the ORG for each phenotype, and to
investigate disease progression.
Explain how the sample size was calculated, and determine the posterior power
of the study.
Omit the discriminant and ROC analysis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Reviewer's report
Title:Multi-susceptibility genes associated with esophageal squamous cell
cancer risk and their potential use to identify subjects at high risk
Version: 1Date:22 March 2011
Reviewer: Elias Zintzaras
Reviewer's report:
For each variant, calculate the unadjusted and adjusted OR for the allele contrast
(only unadjusted), dominant, recessive, additive and co-dominant models (See
Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent
gene-disease associations requires appropriate methodological and statistical
approaches. J Clin Epidemiol. 2008 Jul;61(7):634-45).
An additional analysis based on the generalized odds ratio (ORG) should be
performed (see Zintzaras E. The generalized odds ratio as a measure of genetic
risk effect in the analysis and meta-analysis of association studies. Stat Appl
Genet Mol Biol. 2010;9(1):Article21) The ORG utilizes the complete genotype
distribution and provides an estimate of the magnitude of the association
between disease status (disease vs. healthy or disease progression) and
genotype (biallelic or multiallelic). So, apply the ORG for each phenotype, and to
investigate disease progression.
Explain how the sample size was calculated, and determine the posterior power
of the study.
Omit the discriminant and ROC analysis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
Please review this paper.
user
Reviewer's report
Title:Multi-susceptibility genes associated with esophageal squamous cell
cancer risk and their potential use to identify subjects at high risk
Version: 1Date:22 March 2011
Reviewer: Elias Zintzaras
Reviewer's report:
For each variant, calculate the unadjusted and adjusted OR for the allele contrast
(only unadjusted), dominant, recessive, additive and co-dominant models (See
Zintzaras E, Lau J. Synthesis of genetic association studies for pertinent
gene-disease associations requires appropriate methodological and statistical
approaches. J Clin Epidemiol. 2008 Jul;61(7):634-45).
An additional analysis based on the generalized odds ratio (ORG) should be
performed (see Zintzaras E. The generalized odds ratio as a measure of genetic
risk effect in the analysis and meta-analysis of association studies. Stat Appl
Genet Mol Biol. 2010;9(1):Article21) The ORG utilizes the complete genotype
distribution and provides an estimate of the magnitude of the association
between disease status (disease vs. healthy or disease progression) and
genotype (biallelic or multiallelic). So, apply the ORG for each phenotype, and to
investigate disease progression.
Explain how the sample size was calculated, and determine the posterior power
of the study.
Omit the discriminant and ROC analysis.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
'I declare that I have no competing interests'
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