Title: Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with
colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence
studies
Version: 2 Date: 08 Dec 2024
Reviewer:  Rajdeep Singh
Reviewer's report:
Review: Global Prevalence of Fusobacterium nucleatum and Bacteroides fragilis in Colorectal
Cancer
The study systematically reviews and synthesizes data across multiple geographic regions,
providing a global perspective on the prevalence of these bacteria in CRC. By linking specific
bacteria to CRC progression, the research offers valuable insights for developing microbiota-
targeted diagnostics and therapies. Robust Methodology: The use of PRISMA guidelines and
advanced statistical tools ensures the reliability and reproducibility of the findings.
The absence of data from Africa and limited representation from Oceania restricts the global
applicability of the findings.  High variability among included studies could influence the
generalizability of the results.
This research is impactful as it  Highlights gut microbiota's role in CRC, encouraging further
exploration of its diagnostic and therapeutic potential. Serves as a foundation for future studies,
particularly in underrepresented regions.  Influences clinical practice by emphasizing the
importance of microbial screening in CRC management.
In conclusion, this manuscript significantly contributes to the understanding of gut microbiota's
role in CRC.
Title: Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with
colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence
studies
Version: 2 Date: 08 Dec 2024
Reviewer:  Rajdeep Singh
Reviewer's report:
Review: Global Prevalence of Fusobacterium nucleatum and Bacteroides fragilis in Colorectal
Cancer
The study systematically reviews and synthesizes data across multiple geographic regions,
providing a global perspective on the prevalence of these bacteria in CRC. By linking specific
bacteria to CRC progression, the research offers valuable insights for developing microbiota-
targeted diagnostics and therapies. Robust Methodology: The use of PRISMA guidelines and
advanced statistical tools ensures the reliability and reproducibility of the findings.
The absence of data from Africa and limited representation from Oceania restricts the global
applicability of the findings.  High variability among included studies could influence the
generalizability of the results.
This research is impactful as it  Highlights gut microbiota's role in CRC, encouraging further
exploration of its diagnostic and therapeutic potential. Serves as a foundation for future studies,
particularly in underrepresented regions.  Influences clinical practice by emphasizing the
importance of microbial screening in CRC management.
In conclusion, this manuscript significantly contributes to the understanding of gut microbiota's
role in CRC.
Please review this paper.
user
Title: Global prevalence of Fusobacterium nucleatum and Bacteroides fragilis in patients with
colorectal cancer: an overview of case reports/case series and meta-analysis of prevalence
studies
Version: 2 Date: 08 Dec 2024
Reviewer:  Rajdeep Singh
Reviewer's report:
Review: Global Prevalence of Fusobacterium nucleatum and Bacteroides fragilis in Colorectal
Cancer
The study systematically reviews and synthesizes data across multiple geographic regions,
providing a global perspective on the prevalence of these bacteria in CRC. By linking specific
bacteria to CRC progression, the research offers valuable insights for developing microbiota-
targeted diagnostics and therapies. Robust Methodology: The use of PRISMA guidelines and
advanced statistical tools ensures the reliability and reproducibility of the findings.
The absence of data from Africa and limited representation from Oceania restricts the global
applicability of the findings.  High variability among included studies could influence the
generalizability of the results.
This research is impactful as it  Highlights gut microbiota's role in CRC, encouraging further
exploration of its diagnostic and therapeutic potential. Serves as a foundation for future studies,
particularly in underrepresented regions.  Influences clinical practice by emphasizing the
importance of microbial screening in CRC management.
In conclusion, this manuscript significantly contributes to the understanding of gut microbiota's
role in CRC.
assistant