Title: The intestinal flora and nutritional status and immune function characteristics of obese
colon cancer patients
Version: 0 Date: 07 Jan 2024
Reviewer's report:
Authors of the article investigated various inflammatory and nutritional parameters of obese
CRC patients pre- and postoperatively.
The following questions raised:
1. Statistical analysis of the study must be updated. Although several parameters were measured
at several timepoints, no longitudinal analyses were performed, either in the form of mixed
effect modeling or by using longitudinal correlation analyses. The current methodology must
be updated.
2. Most results the Authors presented have direct connection to the fact, that after surgery, first
every parameter will worsen (1 week postop results), and then will they only improve (1 month
postop results). These were not discussed anywhere in the manuscript.
3. Due to the two above issues, the novelty of the manuscript is in question.
4. Significant English editing is required.
5. Please explain the following: "for tumour death, local recurrence and distant metastasis, and
the association of local recurrence and distant metastasis with each factor was assessed with the
help of chi-square test".
6. Longitudinal survival modeling would be benefitial: either the use of extended Cox models
with time-dependent variants, or joint-modeling is suggested.
7. Post-hoc analysis for 2+ group-comparisions were not presented, incl. survival curve
differences.
8. "This is similar and consistent with the majority of studies reported." Citatons are needed.
Title: The intestinal flora and nutritional status and immune function characteristics of obese
colon cancer patients
Version: 0 Date: 07 Jan 2024
Reviewer's report:
Authors of the article investigated various inflammatory and nutritional parameters of obese
CRC patients pre- and postoperatively.
The following questions raised:
1. Statistical analysis of the study must be updated. Although several parameters were measured
at several timepoints, no longitudinal analyses were performed, either in the form of mixed
effect modeling or by using longitudinal correlation analyses. The current methodology must
be updated.
2. Most results the Authors presented have direct connection to the fact, that after surgery, first
every parameter will worsen (1 week postop results), and then will they only improve (1 month
postop results). These were not discussed anywhere in the manuscript.
3. Due to the two above issues, the novelty of the manuscript is in question.
4. Significant English editing is required.
5. Please explain the following: "for tumour death, local recurrence and distant metastasis, and
the association of local recurrence and distant metastasis with each factor was assessed with the
help of chi-square test".
6. Longitudinal survival modeling would be benefitial: either the use of extended Cox models
with time-dependent variants, or joint-modeling is suggested.
7. Post-hoc analysis for 2+ group-comparisions were not presented, incl. survival curve
differences.
8. "This is similar and consistent with the majority of studies reported." Citatons are needed.
Please review this paper.
user
Title: The intestinal flora and nutritional status and immune function characteristics of obese
colon cancer patients
Version: 0 Date: 07 Jan 2024
Reviewer's report:
Authors of the article investigated various inflammatory and nutritional parameters of obese
CRC patients pre- and postoperatively.
The following questions raised:
1. Statistical analysis of the study must be updated. Although several parameters were measured
at several timepoints, no longitudinal analyses were performed, either in the form of mixed
effect modeling or by using longitudinal correlation analyses. The current methodology must
be updated.
2. Most results the Authors presented have direct connection to the fact, that after surgery, first
every parameter will worsen (1 week postop results), and then will they only improve (1 month
postop results). These were not discussed anywhere in the manuscript.
3. Due to the two above issues, the novelty of the manuscript is in question.
4. Significant English editing is required.
5. Please explain the following: "for tumour death, local recurrence and distant metastasis, and
the association of local recurrence and distant metastasis with each factor was assessed with the
help of chi-square test".
6. Longitudinal survival modeling would be benefitial: either the use of extended Cox models
with time-dependent variants, or joint-modeling is suggested.
7. Post-hoc analysis for 2+ group-comparisions were not presented, incl. survival curve
differences.
8. "This is similar and consistent with the majority of studies reported." Citatons are needed.
assistant