Title: Effect of Helicobacter pylori Eradication on Metabolic Profile: An International,
Multicenter, Case-Control Study
Version: 3 Date: 31 Oct 2022
Reviewer's report:
As a chronic infection, the study on the relationship between Helicobacter pylori infection
and human metabolism is one of the hot issues in recent years. The authors investigated
the relationship between HP infection eradication and metabolic profile. They found HP
infection eradication significantly reduce the serum TG levels in the patients with successful
eradication, and higher prevalence of comorbidities such as hypertension and hyperlipidemia
among resistant cases who fail to achieve HP eradication. The treatment of HP infection patients
with comorbidities deserves further exploration.
There are some problems:
1 “Two weeks after the end of the treatment period and discontinuation of the drugs, a stool
antigen test (SATs) performed to prove the eradication and the effectiveness of the treatment.”
Many guidelines recommend that to determine whether the eradication of HP is successful
should be at least 4 weeks after the end of the treatment period. Why did the present study
perform SATs 2 weeks after discontinuation of the drugs? Will false negative test results increase
after 2 weeks of drug withdrawal, thus affecting the results of the present study?
2 When evaluated the metabolic profiles on patients 3 months after the end of treatment, has the
infection status of Helicobacter pylori been determined again?
Title: Effect of Helicobacter pylori Eradication on Metabolic Profile: An International,
Multicenter, Case-Control Study
Version: 3 Date: 31 Oct 2022
Reviewer's report:
As a chronic infection, the study on the relationship between Helicobacter pylori infection
and human metabolism is one of the hot issues in recent years. The authors investigated
the relationship between HP infection eradication and metabolic profile. They found HP
infection eradication significantly reduce the serum TG levels in the patients with successful
eradication, and higher prevalence of comorbidities such as hypertension and hyperlipidemia
among resistant cases who fail to achieve HP eradication. The treatment of HP infection patients
with comorbidities deserves further exploration.
There are some problems:
1 “Two weeks after the end of the treatment period and discontinuation of the drugs, a stool
antigen test (SATs) performed to prove the eradication and the effectiveness of the treatment.”
Many guidelines recommend that to determine whether the eradication of HP is successful
should be at least 4 weeks after the end of the treatment period. Why did the present study
perform SATs 2 weeks after discontinuation of the drugs? Will false negative test results increase
after 2 weeks of drug withdrawal, thus affecting the results of the present study?
2 When evaluated the metabolic profiles on patients 3 months after the end of treatment, has the
infection status of Helicobacter pylori been determined again?
Please review this paper.
user
Title: Effect of Helicobacter pylori Eradication on Metabolic Profile: An International,
Multicenter, Case-Control Study
Version: 3 Date: 31 Oct 2022
Reviewer's report:
As a chronic infection, the study on the relationship between Helicobacter pylori infection
and human metabolism is one of the hot issues in recent years. The authors investigated
the relationship between HP infection eradication and metabolic profile. They found HP
infection eradication significantly reduce the serum TG levels in the patients with successful
eradication, and higher prevalence of comorbidities such as hypertension and hyperlipidemia
among resistant cases who fail to achieve HP eradication. The treatment of HP infection patients
with comorbidities deserves further exploration.
There are some problems:
1 “Two weeks after the end of the treatment period and discontinuation of the drugs, a stool
antigen test (SATs) performed to prove the eradication and the effectiveness of the treatment.”
Many guidelines recommend that to determine whether the eradication of HP is successful
should be at least 4 weeks after the end of the treatment period. Why did the present study
perform SATs 2 weeks after discontinuation of the drugs? Will false negative test results increase
after 2 weeks of drug withdrawal, thus affecting the results of the present study?
2 When evaluated the metabolic profiles on patients 3 months after the end of treatment, has the
infection status of Helicobacter pylori been determined again?
assistant