Reviewer ’s report  
 
Title: Lupus enteritis masquerading as Crohn´s disease  
 
Version: 1 Date: 09 Jun 2018  
 
Reviewer: Piotr Eder  
 
Reviewer's report:  
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versio ns of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
I read with interest the paper by Zhu XL. The presented case re port is interesting, however I have 
some major comments.  
 
I am really not completely sure about the diagnosis of SLE. Before this kind of diagnosis in a 71 -
year-old male (what is not typical for SLE), multiple alternative reasons of ulcerations in the GI 
tract should be excluded.  
 
What about GI infectious diseases (i.a. C. difficile, Salmonella/Shigella, Campylobacter, 
Yersinia, GI histoplasmosis and many more), vasculitis, GI sarcoidosis and other potential 
etiological factors? Were they exluded?  
 
What abou t the post mortem examination? I think that this kind of assessment is always crucial 
in the most diffucult diagnostic cases? Was the autopsy of the patient done?  
 
Moreover, the language should be significantly improved.   
 
Are the methods appropri ate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions d rawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in t he past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisat ion t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursemen ts, fees, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to t his paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I unders tand that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my  named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Lupus enteritis masquerading as Crohn´s disease  
 
Version: 1 Date: 09 Jun 2018  
 
Reviewer: Piotr Eder  
 
Reviewer's report:  
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versio ns of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
I read with interest the paper by Zhu XL. The presented case re port is interesting, however I have 
some major comments.  
 
I am really not completely sure about the diagnosis of SLE. Before this kind of diagnosis in a 71 -
year-old male (what is not typical for SLE), multiple alternative reasons of ulcerations in the GI 
tract should be excluded.  
 
What about GI infectious diseases (i.a. C. difficile, Salmonella/Shigella, Campylobacter, 
Yersinia, GI histoplasmosis and many more), vasculitis, GI sarcoidosis and other potential 
etiological factors? Were they exluded?  
 
What abou t the post mortem examination? I think that this kind of assessment is always crucial 
in the most diffucult diagnostic cases? Was the autopsy of the patient done?  
 
Moreover, the language should be significantly improved.   
 
Are the methods appropri ate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions d rawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in t he past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisat ion t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursemen ts, fees, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to t his paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I unders tand that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my  named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Lupus enteritis masquerading as Crohn´s disease  
 
Version: 1 Date: 09 Jun 2018  
 
Reviewer: Piotr Eder  
 
Reviewer's report:  
Please include all comments for the authors in this box rather than uploading your report as an 
attachment. Please only upload as attachments annotated versio ns of manuscripts, graphs, 
supporting materials or other aspects of your report which cannot be included in a text format.  
Please overwrite this text when adding your comments to the authors.  
 
I read with interest the paper by Zhu XL. The presented case re port is interesting, however I have 
some major comments.  
 
I am really not completely sure about the diagnosis of SLE. Before this kind of diagnosis in a 71 -
year-old male (what is not typical for SLE), multiple alternative reasons of ulcerations in the GI 
tract should be excluded.  
 
What about GI infectious diseases (i.a. C. difficile, Salmonella/Shigella, Campylobacter, 
Yersinia, GI histoplasmosis and many more), vasculitis, GI sarcoidosis and other potential 
etiological factors? Were they exluded?  
 
What abou t the post mortem examination? I think that this kind of assessment is always crucial 
in the most diffucult diagnostic cases? Was the autopsy of the patient done?  
 
Moreover, the language should be significantly improved.   
 
Are the methods appropri ate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Unable to assess  
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Unable to assess  
 
Are the conclusions d rawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Unable to assess  
 
Are you able to assess any statistics in the manus cript or would you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
1. Have you in t he past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisat ion t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents  relating to the content of the 
manuscript?  
 
4. Have you received reimbursemen ts, fees, funding, or salary from an organization that holds 
or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to t his paper?  
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests' 
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I unders tand that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my  named report 
including any attachments I upload will be posted on the website along with the authors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be in cluded as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant