Title: Prognostic and Therapeutic Potential of CXCR6 Expression on CD8+ T Cells in Gastric
Cancer: A Retrospective Cohort Study
Version: 0 Date: 15 Jan 2025
Reviewer's report:
CXCR6 is chemokine receptor 6, which has an inherent role in the infiltration of immune cells
into the tumor microenvironment. By analyzing the infiltration of immune cells in gastric cancer
tissues, the article discovers the correlation between the infiltration of CD8+ T cells and clinical
characteristics. Furthermore, through the analysis and detection of CXCR6, it is concluded
that CXCR6 could be a potential predictive indicator for the immunotherapy of gastric cancer.
However, most of the data are based on bioinformatics analysis, lacking more robust cell and
animal experiments. The authors have already mentioned this point in the discussion section.
Before the paper can be accepted, I believe the following information is also required:
1. In the univariate analysis, the correlation between CXCR6 and the prognosis of gastric cancer
is mentioned. Could the authors provide the reason for choosing this target? Have they conducted
a multivariate analysis of chemokines? What are the results? These could be elaborated in the
discussion section.
2. Tumor cells can also express chemokine receptors. In the tumor microenvironment, what is
the relationship between the chemokines expressed by gastric cancer cells and those expressed
by CD8+ T cells? Did the authors make corresponding distinctions when conducting the
bioinformatics analysis? Please clarify.
Title: Prognostic and Therapeutic Potential of CXCR6 Expression on CD8+ T Cells in Gastric
Cancer: A Retrospective Cohort Study
Version: 0 Date: 15 Jan 2025
Reviewer's report:
CXCR6 is chemokine receptor 6, which has an inherent role in the infiltration of immune cells
into the tumor microenvironment. By analyzing the infiltration of immune cells in gastric cancer
tissues, the article discovers the correlation between the infiltration of CD8+ T cells and clinical
characteristics. Furthermore, through the analysis and detection of CXCR6, it is concluded
that CXCR6 could be a potential predictive indicator for the immunotherapy of gastric cancer.
However, most of the data are based on bioinformatics analysis, lacking more robust cell and
animal experiments. The authors have already mentioned this point in the discussion section.
Before the paper can be accepted, I believe the following information is also required:
1. In the univariate analysis, the correlation between CXCR6 and the prognosis of gastric cancer
is mentioned. Could the authors provide the reason for choosing this target? Have they conducted
a multivariate analysis of chemokines? What are the results? These could be elaborated in the
discussion section.
2. Tumor cells can also express chemokine receptors. In the tumor microenvironment, what is
the relationship between the chemokines expressed by gastric cancer cells and those expressed
by CD8+ T cells? Did the authors make corresponding distinctions when conducting the
bioinformatics analysis? Please clarify.
Please review this paper.
user
Title: Prognostic and Therapeutic Potential of CXCR6 Expression on CD8+ T Cells in Gastric
Cancer: A Retrospective Cohort Study
Version: 0 Date: 15 Jan 2025
Reviewer's report:
CXCR6 is chemokine receptor 6, which has an inherent role in the infiltration of immune cells
into the tumor microenvironment. By analyzing the infiltration of immune cells in gastric cancer
tissues, the article discovers the correlation between the infiltration of CD8+ T cells and clinical
characteristics. Furthermore, through the analysis and detection of CXCR6, it is concluded
that CXCR6 could be a potential predictive indicator for the immunotherapy of gastric cancer.
However, most of the data are based on bioinformatics analysis, lacking more robust cell and
animal experiments. The authors have already mentioned this point in the discussion section.
Before the paper can be accepted, I believe the following information is also required:
1. In the univariate analysis, the correlation between CXCR6 and the prognosis of gastric cancer
is mentioned. Could the authors provide the reason for choosing this target? Have they conducted
a multivariate analysis of chemokines? What are the results? These could be elaborated in the
discussion section.
2. Tumor cells can also express chemokine receptors. In the tumor microenvironment, what is
the relationship between the chemokines expressed by gastric cancer cells and those expressed
by CD8+ T cells? Did the authors make corresponding distinctions when conducting the
bioinformatics analysis? Please clarify.
assistant