Title: The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the
Han population in Northeast China
Version: 3 Date: 31 May 2021
Reviewer's report:
The authors have considerably improved the manuscript and answered my suggestions with
just two exceptions. The first was about the multiple test correction, where they use a poor
justification for its absence (the fact that another paper did not use it). In my opinion, the authors
are partially right in saying that Bonferroni is very strict when it comes to little cohorts. Anyway,
I think that a brief sentence about the results using the correction (or a column in the tables with
the adjusted p-value) could improve the clarity and the scientific integrity of the work.
The second point was the use of smoking status as a covariate in a model where you already
stratified for smoking status (if I have understood correctly), which results in an over-adjustment
possible abolishing significant associations (if any).
In summary, the revised version of the work is still simple and maybe too simplistic, but it
provides clear and concise results on the topic.
Title: The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the
Han population in Northeast China
Version: 3 Date: 31 May 2021
Reviewer's report:
The authors have considerably improved the manuscript and answered my suggestions with
just two exceptions. The first was about the multiple test correction, where they use a poor
justification for its absence (the fact that another paper did not use it). In my opinion, the authors
are partially right in saying that Bonferroni is very strict when it comes to little cohorts. Anyway,
I think that a brief sentence about the results using the correction (or a column in the tables with
the adjusted p-value) could improve the clarity and the scientific integrity of the work.
The second point was the use of smoking status as a covariate in a model where you already
stratified for smoking status (if I have understood correctly), which results in an over-adjustment
possible abolishing significant associations (if any).
In summary, the revised version of the work is still simple and maybe too simplistic, but it
provides clear and concise results on the topic.
Please review this paper.
user
Title: The rs9953490 polymorphism of DAL-1 gene is associated with gastric cancer risk in the
Han population in Northeast China
Version: 3 Date: 31 May 2021
Reviewer's report:
The authors have considerably improved the manuscript and answered my suggestions with
just two exceptions. The first was about the multiple test correction, where they use a poor
justification for its absence (the fact that another paper did not use it). In my opinion, the authors
are partially right in saying that Bonferroni is very strict when it comes to little cohorts. Anyway,
I think that a brief sentence about the results using the correction (or a column in the tables with
the adjusted p-value) could improve the clarity and the scientific integrity of the work.
The second point was the use of smoking status as a covariate in a model where you already
stratified for smoking status (if I have understood correctly), which results in an over-adjustment
possible abolishing significant associations (if any).
In summary, the revised version of the work is still simple and maybe too simplistic, but it
provides clear and concise results on the topic.
assistant