Title: Risk Factors of Severe Hepatotoxicity Among HIV-1 infected Individuals initiated on
Highly Active Antiretroviral Therapy in the Northwest Region of Cameroon
Version: 1 Date: 06 Nov 2021
Reviewer:  Henry D Meriki
Reviewer's report:
Abstract:
- Line 40: Describe demographic characteristics of study participants
- Line 42: exact p-value should be mentioned and all through the manuscript
Methods
- Lines 89-90: Are these the only regimen options available or these are regimen option you
choose to include in your study?
- Line 104-105: Give the ranges of these hepatotoxicities according to the grades (1 – 4), for
example grade 1 (value range)
- Line 110: SEM define at first use
Results
- Table 1 Value in bracket not defined (eg <30years ( 27))
Line 177: State variables controlled for in the analysis
- Line 178:  In the statement "a monthly income of <50,000frs had 0.18 risk of severe
hepatotoxicity" . You meant  a lower or higher risk compared to other groups
- Line 180: It is good to state controlling variables
Discussion
- Lines 207-208: provide a reference for this statement
- Line 235 and 241: Referencing style not uniform
- Lines 250-251: Did your study show this age group consumed alcohol and smoke more than
others? It might be helpful to do such analysis
- Line 253, 267: These are assumptions or add reference backing
- Line 274-276: Low income earners consume more dietary fat than high income earners? The
reverse might be true
Conclusion
- Lines 324-325: What kind of education? Nutrition, alcohol and smoking abstention etc. For
example Nutrition is part of the care package for PLHIV
Limitations
- Lines 335-336: In your methodology you indicated adherence was assessed using self-report
and pill counts, but you did not consider this in your analysis?
- Line 338: You mentioned liver histology could not be performed, however, you have all
necessary serum markers That could be used to assess liver fibrosis (such APRI, FIB-4 etc).
Title: Risk Factors of Severe Hepatotoxicity Among HIV-1 infected Individuals initiated on
Highly Active Antiretroviral Therapy in the Northwest Region of Cameroon
Version: 1 Date: 06 Nov 2021
Reviewer:  Henry D Meriki
Reviewer's report:
Abstract:
- Line 40: Describe demographic characteristics of study participants
- Line 42: exact p-value should be mentioned and all through the manuscript
Methods
- Lines 89-90: Are these the only regimen options available or these are regimen option you
choose to include in your study?
- Line 104-105: Give the ranges of these hepatotoxicities according to the grades (1 – 4), for
example grade 1 (value range)
- Line 110: SEM define at first use
Results
- Table 1 Value in bracket not defined (eg <30years ( 27))
Line 177: State variables controlled for in the analysis
- Line 178:  In the statement "a monthly income of <50,000frs had 0.18 risk of severe
hepatotoxicity" . You meant  a lower or higher risk compared to other groups
- Line 180: It is good to state controlling variables
Discussion
- Lines 207-208: provide a reference for this statement
- Line 235 and 241: Referencing style not uniform
- Lines 250-251: Did your study show this age group consumed alcohol and smoke more than
others? It might be helpful to do such analysis
- Line 253, 267: These are assumptions or add reference backing
- Line 274-276: Low income earners consume more dietary fat than high income earners? The
reverse might be true
Conclusion
- Lines 324-325: What kind of education? Nutrition, alcohol and smoking abstention etc. For
example Nutrition is part of the care package for PLHIV
Limitations
- Lines 335-336: In your methodology you indicated adherence was assessed using self-report
and pill counts, but you did not consider this in your analysis?
- Line 338: You mentioned liver histology could not be performed, however, you have all
necessary serum markers That could be used to assess liver fibrosis (such APRI, FIB-4 etc).
Please review this paper.
user
Title: Risk Factors of Severe Hepatotoxicity Among HIV-1 infected Individuals initiated on
Highly Active Antiretroviral Therapy in the Northwest Region of Cameroon
Version: 1 Date: 06 Nov 2021
Reviewer:  Henry D Meriki
Reviewer's report:
Abstract:
- Line 40: Describe demographic characteristics of study participants
- Line 42: exact p-value should be mentioned and all through the manuscript
Methods
- Lines 89-90: Are these the only regimen options available or these are regimen option you
choose to include in your study?
- Line 104-105: Give the ranges of these hepatotoxicities according to the grades (1 – 4), for
example grade 1 (value range)
- Line 110: SEM define at first use
Results
- Table 1 Value in bracket not defined (eg <30years ( 27))
Line 177: State variables controlled for in the analysis
- Line 178:  In the statement "a monthly income of <50,000frs had 0.18 risk of severe
hepatotoxicity" . You meant  a lower or higher risk compared to other groups
- Line 180: It is good to state controlling variables
Discussion
- Lines 207-208: provide a reference for this statement
- Line 235 and 241: Referencing style not uniform
- Lines 250-251: Did your study show this age group consumed alcohol and smoke more than
others? It might be helpful to do such analysis
- Line 253, 267: These are assumptions or add reference backing
- Line 274-276: Low income earners consume more dietary fat than high income earners? The
reverse might be true
Conclusion
- Lines 324-325: What kind of education? Nutrition, alcohol and smoking abstention etc. For
example Nutrition is part of the care package for PLHIV
Limitations
- Lines 335-336: In your methodology you indicated adherence was assessed using self-report
and pill counts, but you did not consider this in your analysis?
- Line 338: You mentioned liver histology could not be performed, however, you have all
necessary serum markers That could be used to assess liver fibrosis (such APRI, FIB-4 etc).
assistant