Reviewer's report
Title:Early diagnosis of celiac disease in IgA deficient children: contribution of a
Point of Care Test
Version:1Date:17 July 2014
Reviewer: Xavier Bossuyt
Reviewer's report:
The authors have evaluated a point-point-of-care assay for the diagnosis of
celiac disease in IgA deficient children. They conclude that the assay can rule out
celiac disease in patients with IgA deficiency.
Major comment
The number of IgA deficient celiac disease patients included in the study is
limited (only 8). Some previous studies reporting on serologic diagnosis of celiac
disease in IgA deficient patients included more patients (see Villalta et al. Clin
Chem 2010;56:464-8).
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I do not have competing interests.
Reviewer's report
Title:Early diagnosis of celiac disease in IgA deficient children: contribution of a
Point of Care Test
Version:1Date:17 July 2014
Reviewer: Xavier Bossuyt
Reviewer's report:
The authors have evaluated a point-point-of-care assay for the diagnosis of
celiac disease in IgA deficient children. They conclude that the assay can rule out
celiac disease in patients with IgA deficiency.
Major comment
The number of IgA deficient celiac disease patients included in the study is
limited (only 8). Some previous studies reporting on serologic diagnosis of celiac
disease in IgA deficient patients included more patients (see Villalta et al. Clin
Chem 2010;56:464-8).
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I do not have competing interests.
Please review this paper.
user
Reviewer's report
Title:Early diagnosis of celiac disease in IgA deficient children: contribution of a
Point of Care Test
Version:1Date:17 July 2014
Reviewer: Xavier Bossuyt
Reviewer's report:
The authors have evaluated a point-point-of-care assay for the diagnosis of
celiac disease in IgA deficient children. They conclude that the assay can rule out
celiac disease in patients with IgA deficiency.
Major comment
The number of IgA deficient celiac disease patients included in the study is
limited (only 8). Some previous studies reporting on serologic diagnosis of celiac
disease in IgA deficient patients included more patients (see Villalta et al. Clin
Chem 2010;56:464-8).
Level of interest: An article of limited interest
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I do not have competing interests.
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