Title: The effect of an acute aspirin challenge on intestinal permeability in healthy adults
with and without prophylactic probiotic consumption: a double-blind, placebo- controlled,
randomized trial
Version: 1 Date: 19 Oct 2023
Reviewer's report:
This MS interesting and clinically important. The research questions are relevant. The methods
are valid,  carefully described  and suitable to fulfill the aim of the study.
Even if the results do not follow the hypothesis they are clinically important. The possible
failures/limitations  (e.g. choice of probiotics, length of intervention, dose of aspirin, dose of
probiotics) are adequately  described.  As sufficient length  of the baseline period and  especially
the wash-out period  are important in probiotic studies  it had been good to discuss  also their
role, especially on what basis they were chosen and if the authors regard them sufficient.
In table 2 it is difficult to understand the footnotes especially footnote 2) the calculation of the
PPS points vs numbers in the table  and in footnote 3) the wording  "all such values". Please
clarify the text.
The MS is carefully written and well structured and earns to be published without any
reservations.
Title: The effect of an acute aspirin challenge on intestinal permeability in healthy adults
with and without prophylactic probiotic consumption: a double-blind, placebo- controlled,
randomized trial
Version: 1 Date: 19 Oct 2023
Reviewer's report:
This MS interesting and clinically important. The research questions are relevant. The methods
are valid,  carefully described  and suitable to fulfill the aim of the study.
Even if the results do not follow the hypothesis they are clinically important. The possible
failures/limitations  (e.g. choice of probiotics, length of intervention, dose of aspirin, dose of
probiotics) are adequately  described.  As sufficient length  of the baseline period and  especially
the wash-out period  are important in probiotic studies  it had been good to discuss  also their
role, especially on what basis they were chosen and if the authors regard them sufficient.
In table 2 it is difficult to understand the footnotes especially footnote 2) the calculation of the
PPS points vs numbers in the table  and in footnote 3) the wording  "all such values". Please
clarify the text.
The MS is carefully written and well structured and earns to be published without any
reservations.
Please review this paper.
user
Title: The effect of an acute aspirin challenge on intestinal permeability in healthy adults
with and without prophylactic probiotic consumption: a double-blind, placebo- controlled,
randomized trial
Version: 1 Date: 19 Oct 2023
Reviewer's report:
This MS interesting and clinically important. The research questions are relevant. The methods
are valid,  carefully described  and suitable to fulfill the aim of the study.
Even if the results do not follow the hypothesis they are clinically important. The possible
failures/limitations  (e.g. choice of probiotics, length of intervention, dose of aspirin, dose of
probiotics) are adequately  described.  As sufficient length  of the baseline period and  especially
the wash-out period  are important in probiotic studies  it had been good to discuss  also their
role, especially on what basis they were chosen and if the authors regard them sufficient.
In table 2 it is difficult to understand the footnotes especially footnote 2) the calculation of the
PPS points vs numbers in the table  and in footnote 3) the wording  "all such values". Please
clarify the text.
The MS is carefully written and well structured and earns to be published without any
reservations.
assistant