Title: Causal relationship between gut microbiota and constipation: a two-sample Mendelian
randomization study
Version: 2 Date: 04 Feb 2024
Reviewer's report:
In this study, MR was used to analyze the causal relationship between gut microbiota and
constipation for the first time. The authors identified specific types of microbes associated with
constipation, which affords a fresh constipation into the pathogenesis of this disease and the
possibility of developing treatment strategies. However, this analysis
was primarily based on GW AS data from European populations, presenting a limitation.
Future studies involving a broader range of racial and ethnic groups are imperative to
avoid biased estimates and enhance the universality of the findings.
Title: Causal relationship between gut microbiota and constipation: a two-sample Mendelian
randomization study
Version: 2 Date: 04 Feb 2024
Reviewer's report:
In this study, MR was used to analyze the causal relationship between gut microbiota and
constipation for the first time. The authors identified specific types of microbes associated with
constipation, which affords a fresh constipation into the pathogenesis of this disease and the
possibility of developing treatment strategies. However, this analysis
was primarily based on GW AS data from European populations, presenting a limitation.
Future studies involving a broader range of racial and ethnic groups are imperative to
avoid biased estimates and enhance the universality of the findings.
Please review this paper.
user
Title: Causal relationship between gut microbiota and constipation: a two-sample Mendelian
randomization study
Version: 2 Date: 04 Feb 2024
Reviewer's report:
In this study, MR was used to analyze the causal relationship between gut microbiota and
constipation for the first time. The authors identified specific types of microbes associated with
constipation, which affords a fresh constipation into the pathogenesis of this disease and the
possibility of developing treatment strategies. However, this analysis
was primarily based on GW AS data from European populations, presenting a limitation.
Future studies involving a broader range of racial and ethnic groups are imperative to
avoid biased estimates and enhance the universality of the findings.
assistant