Title: PREDICTIVE VALUES OF AN IMMUNOLOGICAL FECAL OCCULT BLOOD
TEST FOR THE DIAGNOSIS OF COLORECTAL CANCER COMPARED USING
COLONOSCOPY IN SYMPTOMATIC PATIENTS IN YAOUNDE (CAMEROON)
Version: 5 Date: 14 Jan 2024
Reviewer:  Rinkalben Kakadiya
Reviewer's report:
Comments to authors
1. Please check the manuscript for the English language. There is incorrect language throughout
the paper, which causes trouble in understanding scientific content. In this case, you may want
to have your manuscript checked/edited and checked for grammar by a native English speaker
or somebody well-versed with it before re-submission, particularly if English is not your first
language. A clear and concise language will help editors and reviewers concentrate on the
scientific content of your paper and thus smoothen the peer review process.
2. The study's objective was “to highlight the predictive value of an iFOB test for the diagnosis
of a CRC at the colonoscopy in the city of Yaoundé (Cameroon).” This needs more clarification
like early CRC, and precancerous lesion. For diagnosis of CRC in symptomatic patients, how
does the result of iFOB affect the decision of colonoscopy? iFOB is used for screening of
asymptomatic patients.
3. In the result section, you have analyzed positive iFOB and the presence of CRC. iFOB is
for screening; I believe you should analyse and describe the presence of early CRC or polyps
concerning iFOB.
4.  In the discussion, it was written like “With this result, we can suggest that, for a patient
presenting some abdominal pains, constipation or diarrhoea, altered general status, anemia with
a negative iFOB test, the risk to have a CRC is low. They can be exempted from a colonoscopy”.
I do not agree with this statement. The symptomatic patient needs a colonoscopy even with
negative iFOB. First, all patients with CRC do not have positive iFOB; in this study, 3(17%) out
of 17 were negative, which is a significant number of cases. Secondly, these symptoms could
be due to IBD, diverticular disease, which also needs colonoscopy.
Title: PREDICTIVE VALUES OF AN IMMUNOLOGICAL FECAL OCCULT BLOOD
TEST FOR THE DIAGNOSIS OF COLORECTAL CANCER COMPARED USING
COLONOSCOPY IN SYMPTOMATIC PATIENTS IN YAOUNDE (CAMEROON)
Version: 5 Date: 14 Jan 2024
Reviewer:  Rinkalben Kakadiya
Reviewer's report:
Comments to authors
1. Please check the manuscript for the English language. There is incorrect language throughout
the paper, which causes trouble in understanding scientific content. In this case, you may want
to have your manuscript checked/edited and checked for grammar by a native English speaker
or somebody well-versed with it before re-submission, particularly if English is not your first
language. A clear and concise language will help editors and reviewers concentrate on the
scientific content of your paper and thus smoothen the peer review process.
2. The study's objective was “to highlight the predictive value of an iFOB test for the diagnosis
of a CRC at the colonoscopy in the city of Yaoundé (Cameroon).” This needs more clarification
like early CRC, and precancerous lesion. For diagnosis of CRC in symptomatic patients, how
does the result of iFOB affect the decision of colonoscopy? iFOB is used for screening of
asymptomatic patients.
3. In the result section, you have analyzed positive iFOB and the presence of CRC. iFOB is
for screening; I believe you should analyse and describe the presence of early CRC or polyps
concerning iFOB.
4.  In the discussion, it was written like “With this result, we can suggest that, for a patient
presenting some abdominal pains, constipation or diarrhoea, altered general status, anemia with
a negative iFOB test, the risk to have a CRC is low. They can be exempted from a colonoscopy”.
I do not agree with this statement. The symptomatic patient needs a colonoscopy even with
negative iFOB. First, all patients with CRC do not have positive iFOB; in this study, 3(17%) out
of 17 were negative, which is a significant number of cases. Secondly, these symptoms could
be due to IBD, diverticular disease, which also needs colonoscopy.
Please review this paper.
user
Title: PREDICTIVE VALUES OF AN IMMUNOLOGICAL FECAL OCCULT BLOOD
TEST FOR THE DIAGNOSIS OF COLORECTAL CANCER COMPARED USING
COLONOSCOPY IN SYMPTOMATIC PATIENTS IN YAOUNDE (CAMEROON)
Version: 5 Date: 14 Jan 2024
Reviewer:  Rinkalben Kakadiya
Reviewer's report:
Comments to authors
1. Please check the manuscript for the English language. There is incorrect language throughout
the paper, which causes trouble in understanding scientific content. In this case, you may want
to have your manuscript checked/edited and checked for grammar by a native English speaker
or somebody well-versed with it before re-submission, particularly if English is not your first
language. A clear and concise language will help editors and reviewers concentrate on the
scientific content of your paper and thus smoothen the peer review process.
2. The study's objective was “to highlight the predictive value of an iFOB test for the diagnosis
of a CRC at the colonoscopy in the city of Yaoundé (Cameroon).” This needs more clarification
like early CRC, and precancerous lesion. For diagnosis of CRC in symptomatic patients, how
does the result of iFOB affect the decision of colonoscopy? iFOB is used for screening of
asymptomatic patients.
3. In the result section, you have analyzed positive iFOB and the presence of CRC. iFOB is
for screening; I believe you should analyse and describe the presence of early CRC or polyps
concerning iFOB.
4.  In the discussion, it was written like “With this result, we can suggest that, for a patient
presenting some abdominal pains, constipation or diarrhoea, altered general status, anemia with
a negative iFOB test, the risk to have a CRC is low. They can be exempted from a colonoscopy”.
I do not agree with this statement. The symptomatic patient needs a colonoscopy even with
negative iFOB. First, all patients with CRC do not have positive iFOB; in this study, 3(17%) out
of 17 were negative, which is a significant number of cases. Secondly, these symptoms could
be due to IBD, diverticular disease, which also needs colonoscopy.
assistant