Reviewer's report
Title:Gene Expression Profiling of Laterally Spreading Tumors
Version:2Date:16 March 2015
Reviewer: Masanobu Takahashi
Reviewer's report:
Major Compulsory Revisions
Minemura et al. have analyzed the gene expression profiling of 41 colorectal
tumors including 17 laterally spreading tumor-type (LST-type) adenomas, 12
LST-carcinomas, and 12 Ip adenomas, and have found that the five genes,
AKT1, BCL2L1, ERBB2, MTA2, and TNFRSF25, were significantly up-regulated
in LST adenomas compared to Ip adenomas. They have also confirmed that
BCL2L1 proteins were significantly up-regulated in another small cohort of 38
patients with LST adenoma. The study may provide additional data that could
help to clarify molecular mechanisms underlying the oncogenesis of this specific
tumor type, LST. However, I feel that the paper shows only preliminary results for
the expressions of some genes and proteins using a quite small number of
patients, and lacks mechanistic experiments to support their hypothesis.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Gene Expression Profiling of Laterally Spreading Tumors
Version:2Date:16 March 2015
Reviewer: Masanobu Takahashi
Reviewer's report:
Major Compulsory Revisions
Minemura et al. have analyzed the gene expression profiling of 41 colorectal
tumors including 17 laterally spreading tumor-type (LST-type) adenomas, 12
LST-carcinomas, and 12 Ip adenomas, and have found that the five genes,
AKT1, BCL2L1, ERBB2, MTA2, and TNFRSF25, were significantly up-regulated
in LST adenomas compared to Ip adenomas. They have also confirmed that
BCL2L1 proteins were significantly up-regulated in another small cohort of 38
patients with LST adenoma. The study may provide additional data that could
help to clarify molecular mechanisms underlying the oncogenesis of this specific
tumor type, LST. However, I feel that the paper shows only preliminary results for
the expressions of some genes and proteins using a quite small number of
patients, and lacks mechanistic experiments to support their hypothesis.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Gene Expression Profiling of Laterally Spreading Tumors
Version:2Date:16 March 2015
Reviewer: Masanobu Takahashi
Reviewer's report:
Major Compulsory Revisions
Minemura et al. have analyzed the gene expression profiling of 41 colorectal
tumors including 17 laterally spreading tumor-type (LST-type) adenomas, 12
LST-carcinomas, and 12 Ip adenomas, and have found that the five genes,
AKT1, BCL2L1, ERBB2, MTA2, and TNFRSF25, were significantly up-regulated
in LST adenomas compared to Ip adenomas. They have also confirmed that
BCL2L1 proteins were significantly up-regulated in another small cohort of 38
patients with LST adenoma. The study may provide additional data that could
help to clarify molecular mechanisms underlying the oncogenesis of this specific
tumor type, LST. However, I feel that the paper shows only preliminary results for
the expressions of some genes and proteins using a quite small number of
patients, and lacks mechanistic experiments to support their hypothesis.
Level of interest: An article of insufficient interest to warrant publication in a
scientific/medical journal
Quality of written English: Not suitable for publication unless extensively edited
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
assistant