Title: Association of Oral Manifestations with Severity of the Disease in Ulcerative Colitis
Patients
Version: 2 Date: 16 Jul 2024
Reviewer:  Bhaskar Kante
Reviewer's report:
Dear Authors, Congratulations to the team for the commendable work on prevalence of oral
manifestations and its correlation with disease activity. The manuscript was well written and I
have few comments for the manucscript highlighted below
1. Abstract needs to be rewritten
2. In the introduction, you can talk about various oral manifestations associated with UC as
shown in other studies
3. In methodology, clinical signs and symptoms such as dysphagia, burning sensation, nausea ,
vomitings symptoms should  not be considered as oral manifestations, before planning the study
why did choose only certain symptoms ?
4. Did you look for common oral manifestations associated with UC such apthous stomatitis,
pyostomatitis vegans, periodonititis, orofacial granulomatosis . It would have been better as per
Dentist assessment, pathology could have taken into consideration
5. In the methodology, it was unclear that why controls were used, did you assess the difference
prevalence of oral symptoms among patients of UC and controls. It was also unclear, did you
take consecutive patients of UC to look for oral symptoms prevalence
6. Did you assess the extent of disease among patients of UC. It would be better to compare the
severity of disease with extent with the oral symptoms
7. What could be possible cause of dysphagia prevalence among the patients of UC. Did you
perform endoscopy to know the cause
8. What are the categories of drugs used by patients in the study, any information on antibiotic
usage,
9. In the discussion, discuss in detail the possible explanation of oral symptoms with UC disease
pathogenesis and its impact on patient of UC
Title: Association of Oral Manifestations with Severity of the Disease in Ulcerative Colitis
Patients
Version: 2 Date: 16 Jul 2024
Reviewer:  Bhaskar Kante
Reviewer's report:
Dear Authors, Congratulations to the team for the commendable work on prevalence of oral
manifestations and its correlation with disease activity. The manuscript was well written and I
have few comments for the manucscript highlighted below
1. Abstract needs to be rewritten
2. In the introduction, you can talk about various oral manifestations associated with UC as
shown in other studies
3. In methodology, clinical signs and symptoms such as dysphagia, burning sensation, nausea ,
vomitings symptoms should  not be considered as oral manifestations, before planning the study
why did choose only certain symptoms ?
4. Did you look for common oral manifestations associated with UC such apthous stomatitis,
pyostomatitis vegans, periodonititis, orofacial granulomatosis . It would have been better as per
Dentist assessment, pathology could have taken into consideration
5. In the methodology, it was unclear that why controls were used, did you assess the difference
prevalence of oral symptoms among patients of UC and controls. It was also unclear, did you
take consecutive patients of UC to look for oral symptoms prevalence
6. Did you assess the extent of disease among patients of UC. It would be better to compare the
severity of disease with extent with the oral symptoms
7. What could be possible cause of dysphagia prevalence among the patients of UC. Did you
perform endoscopy to know the cause
8. What are the categories of drugs used by patients in the study, any information on antibiotic
usage,
9. In the discussion, discuss in detail the possible explanation of oral symptoms with UC disease
pathogenesis and its impact on patient of UC
Please review this paper.
user
Title: Association of Oral Manifestations with Severity of the Disease in Ulcerative Colitis
Patients
Version: 2 Date: 16 Jul 2024
Reviewer:  Bhaskar Kante
Reviewer's report:
Dear Authors, Congratulations to the team for the commendable work on prevalence of oral
manifestations and its correlation with disease activity. The manuscript was well written and I
have few comments for the manucscript highlighted below
1. Abstract needs to be rewritten
2. In the introduction, you can talk about various oral manifestations associated with UC as
shown in other studies
3. In methodology, clinical signs and symptoms such as dysphagia, burning sensation, nausea ,
vomitings symptoms should  not be considered as oral manifestations, before planning the study
why did choose only certain symptoms ?
4. Did you look for common oral manifestations associated with UC such apthous stomatitis,
pyostomatitis vegans, periodonititis, orofacial granulomatosis . It would have been better as per
Dentist assessment, pathology could have taken into consideration
5. In the methodology, it was unclear that why controls were used, did you assess the difference
prevalence of oral symptoms among patients of UC and controls. It was also unclear, did you
take consecutive patients of UC to look for oral symptoms prevalence
6. Did you assess the extent of disease among patients of UC. It would be better to compare the
severity of disease with extent with the oral symptoms
7. What could be possible cause of dysphagia prevalence among the patients of UC. Did you
perform endoscopy to know the cause
8. What are the categories of drugs used by patients in the study, any information on antibiotic
usage,
9. In the discussion, discuss in detail the possible explanation of oral symptoms with UC disease
pathogenesis and its impact on patient of UC
assistant