Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 1 Date: 10 Oct 2023
Reviewer's report:
This is a retrospective, cross-sectional, multicenter study. Patients with chronic constipation
(CC) were devided in two groups according to stable CC treatment (up to two prescription
modification over one year) or unstable (three or more prescription changes for CC). The patients
were followed for at least one and a half years. The authors   identify that proton pump use was
significantly related to the stable CC groups with OR  2.81 (1.12-7).
However this correlation could be byased by the limited number of patients (114)  and their
different distribution of them (n=82 for stable group and 32 for unstable one).
Furthermore, the authors do not mention the kind of drug forCC in each group of patients.,
neither the kind of PPI.
Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 1 Date: 10 Oct 2023
Reviewer's report:
This is a retrospective, cross-sectional, multicenter study. Patients with chronic constipation
(CC) were devided in two groups according to stable CC treatment (up to two prescription
modification over one year) or unstable (three or more prescription changes for CC). The patients
were followed for at least one and a half years. The authors   identify that proton pump use was
significantly related to the stable CC groups with OR  2.81 (1.12-7).
However this correlation could be byased by the limited number of patients (114)  and their
different distribution of them (n=82 for stable group and 32 for unstable one).
Furthermore, the authors do not mention the kind of drug forCC in each group of patients.,
neither the kind of PPI.
Please review this paper.
user
Title: Clinical factors associated with stable treatment of chronic constipation in Japanese
patients
Version: 1 Date: 10 Oct 2023
Reviewer's report:
This is a retrospective, cross-sectional, multicenter study. Patients with chronic constipation
(CC) were devided in two groups according to stable CC treatment (up to two prescription
modification over one year) or unstable (three or more prescription changes for CC). The patients
were followed for at least one and a half years. The authors   identify that proton pump use was
significantly related to the stable CC groups with OR  2.81 (1.12-7).
However this correlation could be byased by the limited number of patients (114)  and their
different distribution of them (n=82 for stable group and 32 for unstable one).
Furthermore, the authors do not mention the kind of drug forCC in each group of patients.,
neither the kind of PPI.
assistant