Title: Low geriatric nutritional risk index is associated with osteoporosis and fracture risk in
patients with chronic liver disease: a cross-sectional study
Version: 0 Date: 24 Sep 2024
Reviewer's report:
The authors presented a cross-sectional study that investigated relationships between  geriatric
nutritional index (GNRI), osteoporosis and FRAX-derived fracture risk in patients with chronic
liver disease. They found that patients with lower GNRI had higher rates of osteoporosis and
higher risk of fracture. Although  similar results have been  already found in studies that involved
patients with specific comorbidities, this is the first study that involved patients with chronic
liver disease. This paper is of real interest,  because of high risk of fracture in the selected
population, and GNRI is a relatively simple calculation tool to assess the risk for  osteoporosis
and fracture. The presentation of work and data are clean, and the methodology is easy follow
through the text.
However, before publication, several things need to be cleared.
#1: In the clinical trials and in everyday practice,  the CKD EPI formula is usually used to
estimate glomerular filtration rate. However, in this paper another formula is used  to estimate
GFR. Is there any specific reason for that?
#2: Serum creatinine, albumin, bilirubin and prothrombin time  are routine laboratory tests
and need no specification about  laboratory methods that were used for their quantification.
However,  M2BPGi is usually not routinely performed and it needs more specification  about
analytical  methods that were used to it.
#3:  I suggest rephrasing sentence in row 166, which starts with 'The all-risk group', by
eliminating any unnecessary 'ANDs' and replacing them with commas.
Title: Low geriatric nutritional risk index is associated with osteoporosis and fracture risk in
patients with chronic liver disease: a cross-sectional study
Version: 0 Date: 24 Sep 2024
Reviewer's report:
The authors presented a cross-sectional study that investigated relationships between  geriatric
nutritional index (GNRI), osteoporosis and FRAX-derived fracture risk in patients with chronic
liver disease. They found that patients with lower GNRI had higher rates of osteoporosis and
higher risk of fracture. Although  similar results have been  already found in studies that involved
patients with specific comorbidities, this is the first study that involved patients with chronic
liver disease. This paper is of real interest,  because of high risk of fracture in the selected
population, and GNRI is a relatively simple calculation tool to assess the risk for  osteoporosis
and fracture. The presentation of work and data are clean, and the methodology is easy follow
through the text.
However, before publication, several things need to be cleared.
#1: In the clinical trials and in everyday practice,  the CKD EPI formula is usually used to
estimate glomerular filtration rate. However, in this paper another formula is used  to estimate
GFR. Is there any specific reason for that?
#2: Serum creatinine, albumin, bilirubin and prothrombin time  are routine laboratory tests
and need no specification about  laboratory methods that were used for their quantification.
However,  M2BPGi is usually not routinely performed and it needs more specification  about
analytical  methods that were used to it.
#3:  I suggest rephrasing sentence in row 166, which starts with 'The all-risk group', by
eliminating any unnecessary 'ANDs' and replacing them with commas.
Please review this paper.
user
Title: Low geriatric nutritional risk index is associated with osteoporosis and fracture risk in
patients with chronic liver disease: a cross-sectional study
Version: 0 Date: 24 Sep 2024
Reviewer's report:
The authors presented a cross-sectional study that investigated relationships between  geriatric
nutritional index (GNRI), osteoporosis and FRAX-derived fracture risk in patients with chronic
liver disease. They found that patients with lower GNRI had higher rates of osteoporosis and
higher risk of fracture. Although  similar results have been  already found in studies that involved
patients with specific comorbidities, this is the first study that involved patients with chronic
liver disease. This paper is of real interest,  because of high risk of fracture in the selected
population, and GNRI is a relatively simple calculation tool to assess the risk for  osteoporosis
and fracture. The presentation of work and data are clean, and the methodology is easy follow
through the text.
However, before publication, several things need to be cleared.
#1: In the clinical trials and in everyday practice,  the CKD EPI formula is usually used to
estimate glomerular filtration rate. However, in this paper another formula is used  to estimate
GFR. Is there any specific reason for that?
#2: Serum creatinine, albumin, bilirubin and prothrombin time  are routine laboratory tests
and need no specification about  laboratory methods that were used for their quantification.
However,  M2BPGi is usually not routinely performed and it needs more specification  about
analytical  methods that were used to it.
#3:  I suggest rephrasing sentence in row 166, which starts with 'The all-risk group', by
eliminating any unnecessary 'ANDs' and replacing them with commas.
assistant