Reviewer's report 
 Integrative roles of transforming growth factor-alpha in the cytoprotection mechanisms of Title: 
gastric mucosal injury 
 1  5 March 2006 Version: Date: 
 Ki-Baik Hahm Reviewer: 
Reviewer's report: 
General 
The manuscript comtains quite well organized and logical results and the athors touched the several 
aspects to prove that TGF-alpha is quite essential in affording the cytoprotection against toxious 
challenge in the stomach. Therefore, as one of the reviewers, I enjoyed the contents and the results 
of the current manuscript except the following minor things to be revised. 
------------------------------------------------------------------------------- Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
1. The authors should improve the quality of pathological results. Also, the author should request the 
immunostaining to expert in these field. For instance, the quality of nNOS and COX-2 
immunostaining must be improved. 2. Even the procaspase-3 was cleaved into two forms, the procasepase expression in WT seems to 
be similar. Also, some slides of frozen sections should be replaced into the slides containing the 
results. ------------------------------------------------------------------------------- Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
1. The description of Introduction is too much long and descriptive. Please reduce the introduction and discussion. 2. Add the the results of COX-1 changes like COX-2 and another Hsp, especially Hsp-27 and 
Hsp-60 in order to have the credits of your observation. 
3. Improve the English. ------------------------------------------------------------------------------- Discretionary Revisions (which the author can choose to ignore) 
 Accept after minor essential revisions What next?: 
 An article of outstanding merit and interest in its field Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 Yes Statistical review: 
Reviewer's report 
 Integrative roles of transforming growth factor-alpha in the cytoprotection mechanisms of Title: 
gastric mucosal injury 
 1  5 March 2006 Version: Date: 
 Ki-Baik Hahm Reviewer: 
Reviewer's report: 
General 
The manuscript comtains quite well organized and logical results and the athors touched the several 
aspects to prove that TGF-alpha is quite essential in affording the cytoprotection against toxious 
challenge in the stomach. Therefore, as one of the reviewers, I enjoyed the contents and the results 
of the current manuscript except the following minor things to be revised. 
------------------------------------------------------------------------------- Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
1. The authors should improve the quality of pathological results. Also, the author should request the 
immunostaining to expert in these field. For instance, the quality of nNOS and COX-2 
immunostaining must be improved. 2. Even the procaspase-3 was cleaved into two forms, the procasepase expression in WT seems to 
be similar. Also, some slides of frozen sections should be replaced into the slides containing the 
results. ------------------------------------------------------------------------------- Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
1. The description of Introduction is too much long and descriptive. Please reduce the introduction and discussion. 2. Add the the results of COX-1 changes like COX-2 and another Hsp, especially Hsp-27 and 
Hsp-60 in order to have the credits of your observation. 
3. Improve the English. ------------------------------------------------------------------------------- Discretionary Revisions (which the author can choose to ignore) 
 Accept after minor essential revisions What next?: 
 An article of outstanding merit and interest in its field Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 Yes Statistical review: 
Please review this paper.
user
Reviewer's report 
 Integrative roles of transforming growth factor-alpha in the cytoprotection mechanisms of Title: 
gastric mucosal injury 
 1  5 March 2006 Version: Date: 
 Ki-Baik Hahm Reviewer: 
Reviewer's report: 
General 
The manuscript comtains quite well organized and logical results and the athors touched the several 
aspects to prove that TGF-alpha is quite essential in affording the cytoprotection against toxious 
challenge in the stomach. Therefore, as one of the reviewers, I enjoyed the contents and the results 
of the current manuscript except the following minor things to be revised. 
------------------------------------------------------------------------------- Major Compulsory Revisions (that the author must respond to before a decision on publication can be reached) 
1. The authors should improve the quality of pathological results. Also, the author should request the 
immunostaining to expert in these field. For instance, the quality of nNOS and COX-2 
immunostaining must be improved. 2. Even the procaspase-3 was cleaved into two forms, the procasepase expression in WT seems to 
be similar. Also, some slides of frozen sections should be replaced into the slides containing the 
results. ------------------------------------------------------------------------------- Minor Essential Revisions (such as missing labels on figures, or the wrong use of a term, which the 
author can be trusted to correct) 
1. The description of Introduction is too much long and descriptive. Please reduce the introduction and discussion. 2. Add the the results of COX-1 changes like COX-2 and another Hsp, especially Hsp-27 and 
Hsp-60 in order to have the credits of your observation. 
3. Improve the English. ------------------------------------------------------------------------------- Discretionary Revisions (which the author can choose to ignore) 
 Accept after minor essential revisions What next?: 
 An article of outstanding merit and interest in its field Level of interest: 
 Needs some language corrections before being published Quality of written English: 
 Yes Statistical review: 
assistant