Title: Effect of KRAS mutation status on clinicopathological characteristics and overall survival
in patients with rectal cancer
Version: 0 Date: 29 Oct 2024
Reviewer's report:
This is an interesting study where  authors aimed to compare wKRAS and mKRAS, as well
as kodon 12 and 13 in rectal  cancer patients with managed with surgical resection. However,
there’s some points which authors should  be care.
First of all, article should be check for typos and grammar, and should be refrase  by the native
english. There a lot of typos, for example “differeniated” should be written “differentiation”
and etc.
Although, authors pointed on limitation that there is no information about NCRT, but I think
it should provided in this study (chemotherapy  drugs, type of radiotherapy -short/long course;
waiting time before the surgery). Also, information about the adj#vant therapy are also essential
when evaluating the survival rates.  Moreover, there’s no information about the surgical
techniques (open, laparoscopic or robotic) which also have a significance effect on the survival.
I will be greatfull if authors  may provide abovementioned issues, and while doing it using the
regarding literature  about these  points.
Thank you!
Title: Effect of KRAS mutation status on clinicopathological characteristics and overall survival
in patients with rectal cancer
Version: 0 Date: 29 Oct 2024
Reviewer's report:
This is an interesting study where  authors aimed to compare wKRAS and mKRAS, as well
as kodon 12 and 13 in rectal  cancer patients with managed with surgical resection. However,
there’s some points which authors should  be care.
First of all, article should be check for typos and grammar, and should be refrase  by the native
english. There a lot of typos, for example “differeniated” should be written “differentiation”
and etc.
Although, authors pointed on limitation that there is no information about NCRT, but I think
it should provided in this study (chemotherapy  drugs, type of radiotherapy -short/long course;
waiting time before the surgery). Also, information about the adj#vant therapy are also essential
when evaluating the survival rates.  Moreover, there’s no information about the surgical
techniques (open, laparoscopic or robotic) which also have a significance effect on the survival.
I will be greatfull if authors  may provide abovementioned issues, and while doing it using the
regarding literature  about these  points.
Thank you!
Please review this paper.
user
Title: Effect of KRAS mutation status on clinicopathological characteristics and overall survival
in patients with rectal cancer
Version: 0 Date: 29 Oct 2024
Reviewer's report:
This is an interesting study where  authors aimed to compare wKRAS and mKRAS, as well
as kodon 12 and 13 in rectal  cancer patients with managed with surgical resection. However,
there’s some points which authors should  be care.
First of all, article should be check for typos and grammar, and should be refrase  by the native
english. There a lot of typos, for example “differeniated” should be written “differentiation”
and etc.
Although, authors pointed on limitation that there is no information about NCRT, but I think
it should provided in this study (chemotherapy  drugs, type of radiotherapy -short/long course;
waiting time before the surgery). Also, information about the adj#vant therapy are also essential
when evaluating the survival rates.  Moreover, there’s no information about the surgical
techniques (open, laparoscopic or robotic) which also have a significance effect on the survival.
I will be greatfull if authors  may provide abovementioned issues, and while doing it using the
regarding literature  about these  points.
Thank you!
assistant