Reviewer's report
Title:The relationship between hepatic resistin overexpression and inflammation
in patients with nonalcoholic steatohepatitis
Version:1Date:3 December 2013
Reviewer: Ali Canbay
Reviewer's report:
Major Compulsory Revisions
1. Did the authors check for M30/M65 in this cohort? This parameter would add
information on the disease state of the presented patients.
2. The authors need to discuss the low number of patients, especially for protein
analyses. The findings are interesting but need to be validated in a larger cohort.
This should be pointed out clearly in the discussion!
3. Did the authors investigate the possible connection between resistin and fetuin
A? At least fetuin A as possible damage markers should be discussed and
appropriate current studies cited (i.e. PMID: 23627434).
Minor Essential Revisions
1. Some prior works have suggested resistin to be associated with NAFLD, the
authors could point to these in their discussion (i.e. reviewed in PMID:
21042023).
2. Scoring of liver damage should be done by the currently accepted system
described by Kleiner et al (NAS) instead of Brunt classification.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:The relationship between hepatic resistin overexpression and inflammation
in patients with nonalcoholic steatohepatitis
Version:1Date:3 December 2013
Reviewer: Ali Canbay
Reviewer's report:
Major Compulsory Revisions
1. Did the authors check for M30/M65 in this cohort? This parameter would add
information on the disease state of the presented patients.
2. The authors need to discuss the low number of patients, especially for protein
analyses. The findings are interesting but need to be validated in a larger cohort.
This should be pointed out clearly in the discussion!
3. Did the authors investigate the possible connection between resistin and fetuin
A? At least fetuin A as possible damage markers should be discussed and
appropriate current studies cited (i.e. PMID: 23627434).
Minor Essential Revisions
1. Some prior works have suggested resistin to be associated with NAFLD, the
authors could point to these in their discussion (i.e. reviewed in PMID:
21042023).
2. Scoring of liver damage should be done by the currently accepted system
described by Kleiner et al (NAS) instead of Brunt classification.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:The relationship between hepatic resistin overexpression and inflammation
in patients with nonalcoholic steatohepatitis
Version:1Date:3 December 2013
Reviewer: Ali Canbay
Reviewer's report:
Major Compulsory Revisions
1. Did the authors check for M30/M65 in this cohort? This parameter would add
information on the disease state of the presented patients.
2. The authors need to discuss the low number of patients, especially for protein
analyses. The findings are interesting but need to be validated in a larger cohort.
This should be pointed out clearly in the discussion!
3. Did the authors investigate the possible connection between resistin and fetuin
A? At least fetuin A as possible damage markers should be discussed and
appropriate current studies cited (i.e. PMID: 23627434).
Minor Essential Revisions
1. Some prior works have suggested resistin to be associated with NAFLD, the
authors could point to these in their discussion (i.e. reviewed in PMID:
21042023).
2. Scoring of liver damage should be done by the currently accepted system
described by Kleiner et al (NAS) instead of Brunt classification.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a statistician.
Declaration of competing interests:
I declare that I have no competing interests
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