Title: Patient-reported symptoms and burden of eosinophilic esophagitis: evidence from real-
world clinical practice
Version: 0 Date: 04 Nov 2023
Reviewer's report:
Dear authors,
I kindly reviewed your paper finding interesting insights as well as downsides to be addressed.
The overall concept of the study, despite its thorough strong design, with far acceptable
reproducibility, lacks of innovative burst. The results of the survey based analysis basically
provide a picture of higher disease and quality of life burden of EoE patients especially of the
symptomatic (despite therapy) versus the asymptomatic ones. No insight is given towards the
characteristics of symptomatic despite treatment patients: why they still experience symptoms?
what kind of symptoms and what correlation is there to explain the substantial non-difference
in histologic activity between the two groups? EoE patients in histologic remission still
experiencing symptoms should be evaluated for functional assessment
and treated accordingly. My advice is to strengthen and apply more focus on this topic, going
beyond descriptive results.
Aside I advice to use acronym for the principle sub-group definition (dysphagia despite
treatment) in order to ease the reader experience.
Moreover extensive english revisions are needed
Title: Patient-reported symptoms and burden of eosinophilic esophagitis: evidence from real-
world clinical practice
Version: 0 Date: 04 Nov 2023
Reviewer's report:
Dear authors,
I kindly reviewed your paper finding interesting insights as well as downsides to be addressed.
The overall concept of the study, despite its thorough strong design, with far acceptable
reproducibility, lacks of innovative burst. The results of the survey based analysis basically
provide a picture of higher disease and quality of life burden of EoE patients especially of the
symptomatic (despite therapy) versus the asymptomatic ones. No insight is given towards the
characteristics of symptomatic despite treatment patients: why they still experience symptoms?
what kind of symptoms and what correlation is there to explain the substantial non-difference
in histologic activity between the two groups? EoE patients in histologic remission still
experiencing symptoms should be evaluated for functional assessment
and treated accordingly. My advice is to strengthen and apply more focus on this topic, going
beyond descriptive results.
Aside I advice to use acronym for the principle sub-group definition (dysphagia despite
treatment) in order to ease the reader experience.
Moreover extensive english revisions are needed
Please review this paper.
user
Title: Patient-reported symptoms and burden of eosinophilic esophagitis: evidence from real-
world clinical practice
Version: 0 Date: 04 Nov 2023
Reviewer's report:
Dear authors,
I kindly reviewed your paper finding interesting insights as well as downsides to be addressed.
The overall concept of the study, despite its thorough strong design, with far acceptable
reproducibility, lacks of innovative burst. The results of the survey based analysis basically
provide a picture of higher disease and quality of life burden of EoE patients especially of the
symptomatic (despite therapy) versus the asymptomatic ones. No insight is given towards the
characteristics of symptomatic despite treatment patients: why they still experience symptoms?
what kind of symptoms and what correlation is there to explain the substantial non-difference
in histologic activity between the two groups? EoE patients in histologic remission still
experiencing symptoms should be evaluated for functional assessment
and treated accordingly. My advice is to strengthen and apply more focus on this topic, going
beyond descriptive results.
Aside I advice to use acronym for the principle sub-group definition (dysphagia despite
treatment) in order to ease the reader experience.
Moreover extensive english revisions are needed
assistant