Reviewer's report
Title:Polymorphisms in gene encoding TRPV1-receptor involved in pain
perception are unrelated to chronic pancreatitis in a Dutch population.
Version: 1Date:24 September 2009
Reviewer: Derek O'Reilly
Reviewer's report:
Polymorphisms in gene encoding TRPV1-receptor involved in pain perception
are unrelated to chronic pancreatitis in a Dutch population.
Overall, this is an excellent paper. The background sets the scene well; providing
a clear rationale for the study. The aim is clearly stated. The laboratory methods
are well described. The statistical analysis is appropriate. The results are clearly
presented. The discussion puts the results in the context of TRPV1 research in
general and in pancreatitis, in particular. The limitations of the study are
acknowledged. The references are appropriate and up to date. The tables and
figures are well constructed and enhance the text.
Major Compulsory Revisions
None.
Minor Essential Revisions
1. Insert “A” before “few” (Background 2nd para, 2nd sentence), if the meaning is
intended to convey that there are sufficient studies to implicate TRPV1 in chronic
pancreatitis, rather than too few.
2. Methods (Subjects):insert “daily” or “per day” into the definition of alcoholic
chronic pancreatitis.
3. Methods (Genotyping – sentence 4): Substitute “accept” with “except”.
4. Discussion (4th para, 2nd sentence): typographical error; “at” rather than “art”.
Discretionary Revisions
1. Methods (Statistical analysis); perhaps define the sample size where Fisher’s
exact size was used).
2. Discussion (limitations); consider addressing those who would wish to see an
alcoholic control group.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Polymorphisms in gene encoding TRPV1-receptor involved in pain
perception are unrelated to chronic pancreatitis in a Dutch population.
Version: 1Date:24 September 2009
Reviewer: Derek O'Reilly
Reviewer's report:
Polymorphisms in gene encoding TRPV1-receptor involved in pain perception
are unrelated to chronic pancreatitis in a Dutch population.
Overall, this is an excellent paper. The background sets the scene well; providing
a clear rationale for the study. The aim is clearly stated. The laboratory methods
are well described. The statistical analysis is appropriate. The results are clearly
presented. The discussion puts the results in the context of TRPV1 research in
general and in pancreatitis, in particular. The limitations of the study are
acknowledged. The references are appropriate and up to date. The tables and
figures are well constructed and enhance the text.
Major Compulsory Revisions
None.
Minor Essential Revisions
1. Insert “A” before “few” (Background 2nd para, 2nd sentence), if the meaning is
intended to convey that there are sufficient studies to implicate TRPV1 in chronic
pancreatitis, rather than too few.
2. Methods (Subjects):insert “daily” or “per day” into the definition of alcoholic
chronic pancreatitis.
3. Methods (Genotyping – sentence 4): Substitute “accept” with “except”.
4. Discussion (4th para, 2nd sentence): typographical error; “at” rather than “art”.
Discretionary Revisions
1. Methods (Statistical analysis); perhaps define the sample size where Fisher’s
exact size was used).
2. Discussion (limitations); consider addressing those who would wish to see an
alcoholic control group.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Polymorphisms in gene encoding TRPV1-receptor involved in pain
perception are unrelated to chronic pancreatitis in a Dutch population.
Version: 1Date:24 September 2009
Reviewer: Derek O'Reilly
Reviewer's report:
Polymorphisms in gene encoding TRPV1-receptor involved in pain perception
are unrelated to chronic pancreatitis in a Dutch population.
Overall, this is an excellent paper. The background sets the scene well; providing
a clear rationale for the study. The aim is clearly stated. The laboratory methods
are well described. The statistical analysis is appropriate. The results are clearly
presented. The discussion puts the results in the context of TRPV1 research in
general and in pancreatitis, in particular. The limitations of the study are
acknowledged. The references are appropriate and up to date. The tables and
figures are well constructed and enhance the text.
Major Compulsory Revisions
None.
Minor Essential Revisions
1. Insert “A” before “few” (Background 2nd para, 2nd sentence), if the meaning is
intended to convey that there are sufficient studies to implicate TRPV1 in chronic
pancreatitis, rather than too few.
2. Methods (Subjects):insert “daily” or “per day” into the definition of alcoholic
chronic pancreatitis.
3. Methods (Genotyping – sentence 4): Substitute “accept” with “except”.
4. Discussion (4th para, 2nd sentence): typographical error; “at” rather than “art”.
Discretionary Revisions
1. Methods (Statistical analysis); perhaps define the sample size where Fisher’s
exact size was used).
2. Discussion (limitations); consider addressing those who would wish to see an
alcoholic control group.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant