Title: Descriptive Analysis of Common Causes of Upper Gastrointestinal Bleeding in Pediatric
Patients in Kerman: A Study from 2022 to 2023
Version: 0 Date: 11 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the study mentions underlying conditions (e.g., Helicobacter pylori, NSAID use), more
detailed data on co-morbidities (such as liver disease, chronic conditions, or previous surgeries)
would provide valuable context for interpreting UGIB etiology, particularly for more complex
cases. Including this information would allow a deeper understanding of how these factors
influence UGIB outcomes.
-The manuscript focuses on the diagnosis and initial management of UGIB, but it does not
address follow-up data or long-term outcomes for the patients. Information on how these patients
fared after the initial treatment (e.g., recurrence of bleeding, need for further interventions) could
enrich the discussion and provide insights into the longer-term management of UGIB in this
population.
-The study mentions that 14 cases (11.6%) did not have a definitive diagnosis despite endoscopic
examination. It would be helpful to discuss potential reasons for this uncertainty. Could these
cases involve rare or less well-known causes of UGIB? Are there specific diagnostic limitations
in the region? Addressing this would give a more comprehensive understanding of the study’s
limitations and potential areas for future research.
-The authors mention that age-dependent variations in UGIB etiology were observed but were
not statistically significant. However, the discussion lacks elaboration on the potential reasons
for this lack of statistical significance. It would be beneficial to briefly explain why these
variations were not statistically significant (e.g., small sample size, insufficient power) and how
this could impact the interpretation of the results.
Title: Descriptive Analysis of Common Causes of Upper Gastrointestinal Bleeding in Pediatric
Patients in Kerman: A Study from 2022 to 2023
Version: 0 Date: 11 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the study mentions underlying conditions (e.g., Helicobacter pylori, NSAID use), more
detailed data on co-morbidities (such as liver disease, chronic conditions, or previous surgeries)
would provide valuable context for interpreting UGIB etiology, particularly for more complex
cases. Including this information would allow a deeper understanding of how these factors
influence UGIB outcomes.
-The manuscript focuses on the diagnosis and initial management of UGIB, but it does not
address follow-up data or long-term outcomes for the patients. Information on how these patients
fared after the initial treatment (e.g., recurrence of bleeding, need for further interventions) could
enrich the discussion and provide insights into the longer-term management of UGIB in this
population.
-The study mentions that 14 cases (11.6%) did not have a definitive diagnosis despite endoscopic
examination. It would be helpful to discuss potential reasons for this uncertainty. Could these
cases involve rare or less well-known causes of UGIB? Are there specific diagnostic limitations
in the region? Addressing this would give a more comprehensive understanding of the study’s
limitations and potential areas for future research.
-The authors mention that age-dependent variations in UGIB etiology were observed but were
not statistically significant. However, the discussion lacks elaboration on the potential reasons
for this lack of statistical significance. It would be beneficial to briefly explain why these
variations were not statistically significant (e.g., small sample size, insufficient power) and how
this could impact the interpretation of the results.
Please review this paper.
user
Title: Descriptive Analysis of Common Causes of Upper Gastrointestinal Bleeding in Pediatric
Patients in Kerman: A Study from 2022 to 2023
Version: 0 Date: 11 Dec 2024
Reviewer:  Anwar Ashraf Abouelnasr
Reviewer's report:
Dear Authors, please address the following points below
-While the study mentions underlying conditions (e.g., Helicobacter pylori, NSAID use), more
detailed data on co-morbidities (such as liver disease, chronic conditions, or previous surgeries)
would provide valuable context for interpreting UGIB etiology, particularly for more complex
cases. Including this information would allow a deeper understanding of how these factors
influence UGIB outcomes.
-The manuscript focuses on the diagnosis and initial management of UGIB, but it does not
address follow-up data or long-term outcomes for the patients. Information on how these patients
fared after the initial treatment (e.g., recurrence of bleeding, need for further interventions) could
enrich the discussion and provide insights into the longer-term management of UGIB in this
population.
-The study mentions that 14 cases (11.6%) did not have a definitive diagnosis despite endoscopic
examination. It would be helpful to discuss potential reasons for this uncertainty. Could these
cases involve rare or less well-known causes of UGIB? Are there specific diagnostic limitations
in the region? Addressing this would give a more comprehensive understanding of the study’s
limitations and potential areas for future research.
-The authors mention that age-dependent variations in UGIB etiology were observed but were
not statistically significant. However, the discussion lacks elaboration on the potential reasons
for this lack of statistical significance. It would be beneficial to briefly explain why these
variations were not statistically significant (e.g., small sample size, insufficient power) and how
this could impact the interpretation of the results.
assistant