Title: Common laboratory blood test immune panel markers are useful for grading ulcerative
colitis endoscopic severity
Version: 1 Date: 18 Nov 2022
Reviewer's report:
This paper is a case-control study evaluating several blood biochemical markers that associate
endoscopic activity in UC patients. A variety of recently reported markers, including those for
other diseases, have been evaluated, however, it is not clear what kinds of messages the authors
wanted to tell us in this study.
Major points
1. Are there situations where either Hs-CRP or CAR would be more useful in this study?
Dr. Furukawa’s study in BMC Gastroenterology 2022 reported that CAR is particularly effective
in patients with long disease duration. And/or is it possible to compare the characteristics of
each marker (NLR, MPV, LMR, etc.)?
2. Did the authors apply to the Research Ethics Committee for this study? This paper appears
not to contain the approval from the Ethics Committee.
Minor points
1. Details used for Hs-CRP and IL-6 measurements are not described - please add descriptions
such as detailed products and measurement range.
2. Please clarify the explanation of the significant difference in the a, b and c letters in tables
3 and 4.
Title: Common laboratory blood test immune panel markers are useful for grading ulcerative
colitis endoscopic severity
Version: 1 Date: 18 Nov 2022
Reviewer's report:
This paper is a case-control study evaluating several blood biochemical markers that associate
endoscopic activity in UC patients. A variety of recently reported markers, including those for
other diseases, have been evaluated, however, it is not clear what kinds of messages the authors
wanted to tell us in this study.
Major points
1. Are there situations where either Hs-CRP or CAR would be more useful in this study?
Dr. Furukawa’s study in BMC Gastroenterology 2022 reported that CAR is particularly effective
in patients with long disease duration. And/or is it possible to compare the characteristics of
each marker (NLR, MPV, LMR, etc.)?
2. Did the authors apply to the Research Ethics Committee for this study? This paper appears
not to contain the approval from the Ethics Committee.
Minor points
1. Details used for Hs-CRP and IL-6 measurements are not described - please add descriptions
such as detailed products and measurement range.
2. Please clarify the explanation of the significant difference in the a, b and c letters in tables
3 and 4.
Please review this paper.
user
Title: Common laboratory blood test immune panel markers are useful for grading ulcerative
colitis endoscopic severity
Version: 1 Date: 18 Nov 2022
Reviewer's report:
This paper is a case-control study evaluating several blood biochemical markers that associate
endoscopic activity in UC patients. A variety of recently reported markers, including those for
other diseases, have been evaluated, however, it is not clear what kinds of messages the authors
wanted to tell us in this study.
Major points
1. Are there situations where either Hs-CRP or CAR would be more useful in this study?
Dr. Furukawa’s study in BMC Gastroenterology 2022 reported that CAR is particularly effective
in patients with long disease duration. And/or is it possible to compare the characteristics of
each marker (NLR, MPV, LMR, etc.)?
2. Did the authors apply to the Research Ethics Committee for this study? This paper appears
not to contain the approval from the Ethics Committee.
Minor points
1. Details used for Hs-CRP and IL-6 measurements are not described - please add descriptions
such as detailed products and measurement range.
2. Please clarify the explanation of the significant difference in the a, b and c letters in tables
3 and 4.
assistant