Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 2 Date: 04 Jan 2021
Reviewer's report:
The manuscript discusses  some key genes involved in the metabolism which came up in the
analyses. However, except referring to some existing literature, the authors didn’t substantiate
the findings with a probable signaling pathway that might be related to the gene  and gene
products identified.
The authors explained why the CNVs from the sex chromosomes were excluded. However,
information from that data could have explained a sex-based severity or risk factor of NAFLD.
The result of CNV study could have been validated with the actual gene expression analyses
from the CNV regions from the cases and controls and presented a graph (potentially a volcano
plot) making the study more convincing
Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 2 Date: 04 Jan 2021
Reviewer's report:
The manuscript discusses  some key genes involved in the metabolism which came up in the
analyses. However, except referring to some existing literature, the authors didn’t substantiate
the findings with a probable signaling pathway that might be related to the gene  and gene
products identified.
The authors explained why the CNVs from the sex chromosomes were excluded. However,
information from that data could have explained a sex-based severity or risk factor of NAFLD.
The result of CNV study could have been validated with the actual gene expression analyses
from the CNV regions from the cases and controls and presented a graph (potentially a volcano
plot) making the study more convincing
Please review this paper.
user
Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 2 Date: 04 Jan 2021
Reviewer's report:
The manuscript discusses  some key genes involved in the metabolism which came up in the
analyses. However, except referring to some existing literature, the authors didn’t substantiate
the findings with a probable signaling pathway that might be related to the gene  and gene
products identified.
The authors explained why the CNVs from the sex chromosomes were excluded. However,
information from that data could have explained a sex-based severity or risk factor of NAFLD.
The result of CNV study could have been validated with the actual gene expression analyses
from the CNV regions from the cases and controls and presented a graph (potentially a volcano
plot) making the study more convincing
assistant