Reviewer's report
Title:Fucoidan present in brown algae induces apoptosis of HT-29 human colon
cancer cells
Version: 2Date:27 July 2010
Reviewer: Nancy Turner
Reviewer's report:
Major Compulsory
1. The title, abstract and introduction give the impression that this work was only
conducted in HT29 cells. However, now there are data from HCT116 cells, so
these should be modified accordingly.
Minor Essential
1. The y-axes in figure 2 should all be on the same scale to make it easier for the
reader to compare the results. Provide the numeric results in panel G, as they
occur for panels E and F.
2. In figure 5, is doesn't appear that the 5 µg/ml fucoidan level caused a
significant increase relative to the control - please check the statistics.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Fucoidan present in brown algae induces apoptosis of HT-29 human colon
cancer cells
Version: 2Date:27 July 2010
Reviewer: Nancy Turner
Reviewer's report:
Major Compulsory
1. The title, abstract and introduction give the impression that this work was only
conducted in HT29 cells. However, now there are data from HCT116 cells, so
these should be modified accordingly.
Minor Essential
1. The y-axes in figure 2 should all be on the same scale to make it easier for the
reader to compare the results. Provide the numeric results in panel G, as they
occur for panels E and F.
2. In figure 5, is doesn't appear that the 5 µg/ml fucoidan level caused a
significant increase relative to the control - please check the statistics.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Fucoidan present in brown algae induces apoptosis of HT-29 human colon
cancer cells
Version: 2Date:27 July 2010
Reviewer: Nancy Turner
Reviewer's report:
Major Compulsory
1. The title, abstract and introduction give the impression that this work was only
conducted in HT29 cells. However, now there are data from HCT116 cells, so
these should be modified accordingly.
Minor Essential
1. The y-axes in figure 2 should all be on the same scale to make it easier for the
reader to compare the results. Provide the numeric results in panel G, as they
occur for panels E and F.
2. In figure 5, is doesn't appear that the 5 µg/ml fucoidan level caused a
significant increase relative to the control - please check the statistics.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interests.
assistant