Reviewer ’s report  
 
Title: Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF -1 and IGF -binding  
Protein 2 in Morbidly Obese Patients  
 
Version: 0 Date: 17 Jan 2020  
 
Reviewer: Cyrus Jahansouz  
 
Reviewer's report:  
 
1. A number of grammatical errors need improved. Examples include the second line of the 
abstract (semicolon needed instead of comma),the first line of the introduction (should be has, 
not has been). Seve ral others are present throughout the paper as well.  
 
2. Have GH, IGF1 and IGFBP2 been previously evaluated before and after gastric bypass or 
sleeve gastrectomy? If so, the discussion would benefit from a comparison of the results from 
this study compared to those studied to better identify how the current study further contributes 
to the current state of knowledge of changes related to bariatric surgery.  
 
3. Do any of the changes of GH or IGFBP2 correlate with any of the metabolic parameters that 
improved f ollowing surgery? Specifically, BMI, weight loss, or HOMA -IR? Any correlations to 
changes in lipid parameters?  
 
4. Do we assume then that IGF does not play a role in the beneficial effects of the sleeve 
gastrectomy since it does not change from before to af ter surgery?  
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to t he authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be includ ed 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF -1 and IGF -binding  
Protein 2 in Morbidly Obese Patients  
 
Version: 0 Date: 17 Jan 2020  
 
Reviewer: Cyrus Jahansouz  
 
Reviewer's report:  
 
1. A number of grammatical errors need improved. Examples include the second line of the 
abstract (semicolon needed instead of comma),the first line of the introduction (should be has, 
not has been). Seve ral others are present throughout the paper as well.  
 
2. Have GH, IGF1 and IGFBP2 been previously evaluated before and after gastric bypass or 
sleeve gastrectomy? If so, the discussion would benefit from a comparison of the results from 
this study compared to those studied to better identify how the current study further contributes 
to the current state of knowledge of changes related to bariatric surgery.  
 
3. Do any of the changes of GH or IGFBP2 correlate with any of the metabolic parameters that 
improved f ollowing surgery? Specifically, BMI, weight loss, or HOMA -IR? Any correlations to 
changes in lipid parameters?  
 
4. Do we assume then that IGF does not play a role in the beneficial effects of the sleeve 
gastrectomy since it does not change from before to af ter surgery?  
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to t he authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be includ ed 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF -1 and IGF -binding  
Protein 2 in Morbidly Obese Patients  
 
Version: 0 Date: 17 Jan 2020  
 
Reviewer: Cyrus Jahansouz  
 
Reviewer's report:  
 
1. A number of grammatical errors need improved. Examples include the second line of the 
abstract (semicolon needed instead of comma),the first line of the introduction (should be has, 
not has been). Seve ral others are present throughout the paper as well.  
 
2. Have GH, IGF1 and IGFBP2 been previously evaluated before and after gastric bypass or 
sleeve gastrectomy? If so, the discussion would benefit from a comparison of the results from 
this study compared to those studied to better identify how the current study further contributes 
to the current state of knowledge of changes related to bariatric surgery.  
 
3. Do any of the changes of GH or IGFBP2 correlate with any of the metabolic parameters that 
improved f ollowing surgery? Specifically, BMI, weight loss, or HOMA -IR? Any correlations to 
changes in lipid parameters?  
 
4. Do we assume then that IGF does not play a role in the beneficial effects of the sleeve 
gastrectomy since it does not change from before to af ter surgery?  
 
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to t he authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I declare that I have no competing interests.  
 
I agree to the open peer review policy of the journal. I understand that my name will be includ ed 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant