Title: Risk Prediction of Second Primary Malignancies in Patients after Rectal Cancer: Analysis
Based on SEER Program
Version: 2 Date: 24 Jul 2023
Reviewer's report:
Yong-Chao Sen and Zi-Dan Zhao et al. investigated Risk Prediction of Second Primary
Malignancies in Patients after Rectal Cancer using SEER database. They presented
novel nomogram predict overall survival after rectal cancers concerning seconds primary
malignancies. Their study is considered to be a fascinating one that takes full advantage of the
characteristics of the SEER database. I have some comments about details of their works.
Major comments
1#Second primary malignancies (SPMs) of their results included rectal cancers. Why were
rectal cancer determined as SPMs? How can we distinguish this from a first rectal cancer
recurrence? A more detailed explanation is needed.
2#How will the nomograms created be used in patient care? Does active screening of upper
SPMs contribute to improved prognosis? Authors should elaborate further in the Discussion
Minor comments
1#SPM should be spell out in first appearance.
Title: Risk Prediction of Second Primary Malignancies in Patients after Rectal Cancer: Analysis
Based on SEER Program
Version: 2 Date: 24 Jul 2023
Reviewer's report:
Yong-Chao Sen and Zi-Dan Zhao et al. investigated Risk Prediction of Second Primary
Malignancies in Patients after Rectal Cancer using SEER database. They presented
novel nomogram predict overall survival after rectal cancers concerning seconds primary
malignancies. Their study is considered to be a fascinating one that takes full advantage of the
characteristics of the SEER database. I have some comments about details of their works.
Major comments
1#Second primary malignancies (SPMs) of their results included rectal cancers. Why were
rectal cancer determined as SPMs? How can we distinguish this from a first rectal cancer
recurrence? A more detailed explanation is needed.
2#How will the nomograms created be used in patient care? Does active screening of upper
SPMs contribute to improved prognosis? Authors should elaborate further in the Discussion
Minor comments
1#SPM should be spell out in first appearance.
Please review this paper.
user
Title: Risk Prediction of Second Primary Malignancies in Patients after Rectal Cancer: Analysis
Based on SEER Program
Version: 2 Date: 24 Jul 2023
Reviewer's report:
Yong-Chao Sen and Zi-Dan Zhao et al. investigated Risk Prediction of Second Primary
Malignancies in Patients after Rectal Cancer using SEER database. They presented
novel nomogram predict overall survival after rectal cancers concerning seconds primary
malignancies. Their study is considered to be a fascinating one that takes full advantage of the
characteristics of the SEER database. I have some comments about details of their works.
Major comments
1#Second primary malignancies (SPMs) of their results included rectal cancers. Why were
rectal cancer determined as SPMs? How can we distinguish this from a first rectal cancer
recurrence? A more detailed explanation is needed.
2#How will the nomograms created be used in patient care? Does active screening of upper
SPMs contribute to improved prognosis? Authors should elaborate further in the Discussion
Minor comments
1#SPM should be spell out in first appearance.
assistant