Reviewer's report
Title:Relationship of 24-hour ambulatory blood pressure and heart rate with
markers of hepatic function in cirrhotic patients
Version: 1Date:18 April 2010
Reviewer: Flemming Bendtsen
Reviewer's report:
The authors performed office and 24 H ambulatory BP and heart rate
measurements in 51 patients with cirrhosis and looked for correlations to
biochemical values and levels of vasoactive hormones. The present is study is
solely a descriptional study and not surprisingly only rather weak correlations
mainly to heart rate were observed.
Major compulsory revisions.
The two groups are not matched according to etiology of cirrhosis, since only
30% of CHILD A patients have alcohol as etiology, while patients with more
severe disease in 60% have alcohol as etiology. Since alcohol by itself may
affect cardiac function,patients need to be stratified according to cause of liver
disease.
I wonder how patients were selected. Were they consquetively recruited (51
patients recruited out of 60 in 30 months?)
Minor essential revisions
Blood samples page 6, line 5, drawn and not drown.
Page 8 top. It is not surprising, that there is a difference between the two groups
with respect to CHILD and MELD score, since the two groups were defined by
this. Can be deleted from the text.
Table 2. Top should be identical with table 1, dividing patients in Group A and
and not in group a and BC. There is problems with the right margen in print.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interest' below.
Reviewer's report
Title:Relationship of 24-hour ambulatory blood pressure and heart rate with
markers of hepatic function in cirrhotic patients
Version: 1Date:18 April 2010
Reviewer: Flemming Bendtsen
Reviewer's report:
The authors performed office and 24 H ambulatory BP and heart rate
measurements in 51 patients with cirrhosis and looked for correlations to
biochemical values and levels of vasoactive hormones. The present is study is
solely a descriptional study and not surprisingly only rather weak correlations
mainly to heart rate were observed.
Major compulsory revisions.
The two groups are not matched according to etiology of cirrhosis, since only
30% of CHILD A patients have alcohol as etiology, while patients with more
severe disease in 60% have alcohol as etiology. Since alcohol by itself may
affect cardiac function,patients need to be stratified according to cause of liver
disease.
I wonder how patients were selected. Were they consquetively recruited (51
patients recruited out of 60 in 30 months?)
Minor essential revisions
Blood samples page 6, line 5, drawn and not drown.
Page 8 top. It is not surprising, that there is a difference between the two groups
with respect to CHILD and MELD score, since the two groups were defined by
this. Can be deleted from the text.
Table 2. Top should be identical with table 1, dividing patients in Group A and
and not in group a and BC. There is problems with the right margen in print.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interest' below.
Please review this paper.
user
Reviewer's report
Title:Relationship of 24-hour ambulatory blood pressure and heart rate with
markers of hepatic function in cirrhotic patients
Version: 1Date:18 April 2010
Reviewer: Flemming Bendtsen
Reviewer's report:
The authors performed office and 24 H ambulatory BP and heart rate
measurements in 51 patients with cirrhosis and looked for correlations to
biochemical values and levels of vasoactive hormones. The present is study is
solely a descriptional study and not surprisingly only rather weak correlations
mainly to heart rate were observed.
Major compulsory revisions.
The two groups are not matched according to etiology of cirrhosis, since only
30% of CHILD A patients have alcohol as etiology, while patients with more
severe disease in 60% have alcohol as etiology. Since alcohol by itself may
affect cardiac function,patients need to be stratified according to cause of liver
disease.
I wonder how patients were selected. Were they consquetively recruited (51
patients recruited out of 60 in 30 months?)
Minor essential revisions
Blood samples page 6, line 5, drawn and not drown.
Page 8 top. It is not surprising, that there is a difference between the two groups
with respect to CHILD and MELD score, since the two groups were defined by
this. Can be deleted from the text.
Table 2. Top should be identical with table 1, dividing patients in Group A and
and not in group a and BC. There is problems with the right margen in print.
Level of interest: An article of limited interest
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I declare that I have no competing interest' below.
assistant