Title: Casual Effect of Ulcerative Colitis on Chronic Heart Failure: Results from a Bidirectional
Mendelian Randomization Study
Version: 0 Date: 25 Nov 2024
Reviewer's report:
1. Data Selection Criteria and Dataset Description
The manuscript lacks a clear explanation of data selection criteria and a comprehensive dataset
description. Including a preliminary table summarizing the dataset characteristics, such as the
age range, gender ratio, and any other relevant demographic or clinical variables, would enhance
transparency and provide readers with a better understanding of the study population.
2. Results Section
The results section would benefit from additional interpretation.
3. Section 3.4 – Definition of "Solid"
The term "solid" in Section 3.4 needs further clarification. For example, are you referring to a
specific level of data quality, robustness of the statistical association, or another characteristic?
4. Conclusion Section – Defining Significant Causal Association
Like the previous comment, the phrase "significant causal association" in the conclusion requires
a more precise definition. Are you referring to statistical significance (e.g., p-value thresholds),
effect size, or practical significance in a real-world context?
Title: Casual Effect of Ulcerative Colitis on Chronic Heart Failure: Results from a Bidirectional
Mendelian Randomization Study
Version: 0 Date: 25 Nov 2024
Reviewer's report:
1. Data Selection Criteria and Dataset Description
The manuscript lacks a clear explanation of data selection criteria and a comprehensive dataset
description. Including a preliminary table summarizing the dataset characteristics, such as the
age range, gender ratio, and any other relevant demographic or clinical variables, would enhance
transparency and provide readers with a better understanding of the study population.
2. Results Section
The results section would benefit from additional interpretation.
3. Section 3.4 – Definition of "Solid"
The term "solid" in Section 3.4 needs further clarification. For example, are you referring to a
specific level of data quality, robustness of the statistical association, or another characteristic?
4. Conclusion Section – Defining Significant Causal Association
Like the previous comment, the phrase "significant causal association" in the conclusion requires
a more precise definition. Are you referring to statistical significance (e.g., p-value thresholds),
effect size, or practical significance in a real-world context?
Please review this paper.
user
Title: Casual Effect of Ulcerative Colitis on Chronic Heart Failure: Results from a Bidirectional
Mendelian Randomization Study
Version: 0 Date: 25 Nov 2024
Reviewer's report:
1. Data Selection Criteria and Dataset Description
The manuscript lacks a clear explanation of data selection criteria and a comprehensive dataset
description. Including a preliminary table summarizing the dataset characteristics, such as the
age range, gender ratio, and any other relevant demographic or clinical variables, would enhance
transparency and provide readers with a better understanding of the study population.
2. Results Section
The results section would benefit from additional interpretation.
3. Section 3.4 – Definition of "Solid"
The term "solid" in Section 3.4 needs further clarification. For example, are you referring to a
specific level of data quality, robustness of the statistical association, or another characteristic?
4. Conclusion Section – Defining Significant Causal Association
Like the previous comment, the phrase "significant causal association" in the conclusion requires
a more precise definition. Are you referring to statistical significance (e.g., p-value thresholds),
effect size, or practical significance in a real-world context?
assistant