Title: Quantitative proteomic studies of the intestinal mucosa provide new insights into the
molecular mechanism of ulcerative colitis
Version: 0 Date: 03 Apr 2024
Reviewer's report:
This an original study entitled “Quantitative proteomic studies of the intestinal mucosa provide
new insights into the molecular mechanism of ulcerative colitis”. The theme is of considerable
current interest for the important clinical implications in terms of therapeutic outcomes as well
as research direction, but there are several issues that the authors should address:
1. Even though this original paper is very interesting there is a huge problem with English
language. The authors should ask a native English speaker to look at the whole manuscript. It is
very hard to read and focus on the content of this study in that form..
2. Keywords should be presented in alphabetical order.
3. Page 5: Study design: healthy control persons?
4. Page 5: What does “another 15 pairs of patients” mean? What was n?
5. Statistical analysis is not described at all. There is no information on the tests used.
6. Table 1./Figures: All abbreviations used should be explained.
7. Some Figures (Figure 1, Figure 3, presented in the manuscript are low quality, simply
unreadable, please improve the quality of the images.
8. Figure 7A: There is no scale bar.
Title: Quantitative proteomic studies of the intestinal mucosa provide new insights into the
molecular mechanism of ulcerative colitis
Version: 0 Date: 03 Apr 2024
Reviewer's report:
This an original study entitled “Quantitative proteomic studies of the intestinal mucosa provide
new insights into the molecular mechanism of ulcerative colitis”. The theme is of considerable
current interest for the important clinical implications in terms of therapeutic outcomes as well
as research direction, but there are several issues that the authors should address:
1. Even though this original paper is very interesting there is a huge problem with English
language. The authors should ask a native English speaker to look at the whole manuscript. It is
very hard to read and focus on the content of this study in that form..
2. Keywords should be presented in alphabetical order.
3. Page 5: Study design: healthy control persons?
4. Page 5: What does “another 15 pairs of patients” mean? What was n?
5. Statistical analysis is not described at all. There is no information on the tests used.
6. Table 1./Figures: All abbreviations used should be explained.
7. Some Figures (Figure 1, Figure 3, presented in the manuscript are low quality, simply
unreadable, please improve the quality of the images.
8. Figure 7A: There is no scale bar.
Please review this paper.
user
Title: Quantitative proteomic studies of the intestinal mucosa provide new insights into the
molecular mechanism of ulcerative colitis
Version: 0 Date: 03 Apr 2024
Reviewer's report:
This an original study entitled “Quantitative proteomic studies of the intestinal mucosa provide
new insights into the molecular mechanism of ulcerative colitis”. The theme is of considerable
current interest for the important clinical implications in terms of therapeutic outcomes as well
as research direction, but there are several issues that the authors should address:
1. Even though this original paper is very interesting there is a huge problem with English
language. The authors should ask a native English speaker to look at the whole manuscript. It is
very hard to read and focus on the content of this study in that form..
2. Keywords should be presented in alphabetical order.
3. Page 5: Study design: healthy control persons?
4. Page 5: What does “another 15 pairs of patients” mean? What was n?
5. Statistical analysis is not described at all. There is no information on the tests used.
6. Table 1./Figures: All abbreviations used should be explained.
7. Some Figures (Figure 1, Figure 3, presented in the manuscript are low quality, simply
unreadable, please improve the quality of the images.
8. Figure 7A: There is no scale bar.
assistant