Title: Clinical factors associated with acute abdominal symptoms induced by gastric anisakiasis:
A multicenter retrospective cohort study
Version: 2 Date: 25 Jun 2023
Reviewer's report:
The MS has been very much improved. I have few minor comments, and only one comment
to work on more seriously.
Spell out EGD at the first mentioning in Methodology
Multiple Anisakis cases – rather change to multiple Anisakis larvae infection. Can authors also
add the reason why this was exclusion criterium?
In discussion change to: Anisakis infection can cause different types of disease
The statement related to eosinophilia and WBC count discrepancy needs more plausible
explanation, as it is not convincing; Page 16, line 13 in Discussion: “…they may be associated
with chronic anisakiasis, which forms masses characterized by eosinophilic granulomas
[29,30].”
Eosinophilia in helminth infections starts early, and is not related to chronic disease [10.1016/
j.iac.2015.05.003]. Besides, you stated earlier that the timing of infection by Anisakis was
unknown, so this factor was appearing in either asymptomatic and symptomatic cases. Could
normal WBC and eosinophilia be related to H. pylori, or some other factor related to diabetes
or mucosal atrophy. Please try to find some tangible evidence from literature.
Page 17, line 13: species molecular identification, rather than species search
Title: Clinical factors associated with acute abdominal symptoms induced by gastric anisakiasis:
A multicenter retrospective cohort study
Version: 2 Date: 25 Jun 2023
Reviewer's report:
The MS has been very much improved. I have few minor comments, and only one comment
to work on more seriously.
Spell out EGD at the first mentioning in Methodology
Multiple Anisakis cases – rather change to multiple Anisakis larvae infection. Can authors also
add the reason why this was exclusion criterium?
In discussion change to: Anisakis infection can cause different types of disease
The statement related to eosinophilia and WBC count discrepancy needs more plausible
explanation, as it is not convincing; Page 16, line 13 in Discussion: “…they may be associated
with chronic anisakiasis, which forms masses characterized by eosinophilic granulomas
[29,30].”
Eosinophilia in helminth infections starts early, and is not related to chronic disease [10.1016/
j.iac.2015.05.003]. Besides, you stated earlier that the timing of infection by Anisakis was
unknown, so this factor was appearing in either asymptomatic and symptomatic cases. Could
normal WBC and eosinophilia be related to H. pylori, or some other factor related to diabetes
or mucosal atrophy. Please try to find some tangible evidence from literature.
Page 17, line 13: species molecular identification, rather than species search
Please review this paper.
user
Title: Clinical factors associated with acute abdominal symptoms induced by gastric anisakiasis:
A multicenter retrospective cohort study
Version: 2 Date: 25 Jun 2023
Reviewer's report:
The MS has been very much improved. I have few minor comments, and only one comment
to work on more seriously.
Spell out EGD at the first mentioning in Methodology
Multiple Anisakis cases – rather change to multiple Anisakis larvae infection. Can authors also
add the reason why this was exclusion criterium?
In discussion change to: Anisakis infection can cause different types of disease
The statement related to eosinophilia and WBC count discrepancy needs more plausible
explanation, as it is not convincing; Page 16, line 13 in Discussion: “…they may be associated
with chronic anisakiasis, which forms masses characterized by eosinophilic granulomas
[29,30].”
Eosinophilia in helminth infections starts early, and is not related to chronic disease [10.1016/
j.iac.2015.05.003]. Besides, you stated earlier that the timing of infection by Anisakis was
unknown, so this factor was appearing in either asymptomatic and symptomatic cases. Could
normal WBC and eosinophilia be related to H. pylori, or some other factor related to diabetes
or mucosal atrophy. Please try to find some tangible evidence from literature.
Page 17, line 13: species molecular identification, rather than species search
assistant