Title: Influential Factors on Disease Activity in Crohn's Disease and Their ROC Curve
Evaluation: A Cross-Sectional Study
Version: 3 Date: 25 Jan 2024
Reviewer's report:
The manuscript addresses a pertinent topic regarding factors affecting CD patients. The study
included a substantial number of participants (n=268); however, only clinical evaluation of the
disease was carried out. Therefore, I have some comments and suggestions to make:
1. Abstract section: In the conclusion, the authors repeat the findings presented in the results.
I suggest changing the conclusion.
2. Introduction section: The anti-inflammatory diet is among the various diets suggested for
managing patients with CD. Despite demonstrating certain positive effects, there is no clear
recommendation for selecting a specific diet in the context of CD. Please rephrase the sentence.
3. Please add the diagnostic criteria established by the Chinese Society of Gastroenterology in
the 'Study Population' section.
4. In the' Clinical Data Collection' section, did the authors mean ulcerative colitis or Crohn's
disease?
5. Which instrument for food intake collection was used to calculate the DII? Please add this
information.
6. Why were fecal calprotectin measurements not performed?
7. Which statistical test was employed to assess the normality of the distribution?
8. Please provide the meaning of the acronym 'M' in the 'Statistical Analysis' section.
9. Please verify the names of the biologic agents in Table 1.
10. Why did the authors categorize patients in remission with mild disease rather than comparing
remission versus activity (mild, moderate, and severe)? The difference in the number of patients
in each group was significant - 183 versus 85.
11. Figure legends: Please provide the meanings of all acronyms appearing in the figures.
12. Discussion - The Importance of Physical Activity: I suggest removing the word 'prevention'
from the fourth line.
13. Discussion - Impact of Dietary Inflammatory Index on Disease Activity in CD Patients: I
suggest changing ‘CD patients are encouraged to increase their intake of foods rich in vitamin
C and vitamin D’ to ‘CD patients are encouraged to increase their intake of fruits, vegetables
and omega-3-fatty acids’.
14. Discussion - Impact of Dietary Inflammatory Index on Disease Activity in CD Patients:
Please add and discuss studies on the effects of the DII in CD.
Title: Influential Factors on Disease Activity in Crohn's Disease and Their ROC Curve
Evaluation: A Cross-Sectional Study
Version: 3 Date: 25 Jan 2024
Reviewer's report:
The manuscript addresses a pertinent topic regarding factors affecting CD patients. The study
included a substantial number of participants (n=268); however, only clinical evaluation of the
disease was carried out. Therefore, I have some comments and suggestions to make:
1. Abstract section: In the conclusion, the authors repeat the findings presented in the results.
I suggest changing the conclusion.
2. Introduction section: The anti-inflammatory diet is among the various diets suggested for
managing patients with CD. Despite demonstrating certain positive effects, there is no clear
recommendation for selecting a specific diet in the context of CD. Please rephrase the sentence.
3. Please add the diagnostic criteria established by the Chinese Society of Gastroenterology in
the 'Study Population' section.
4. In the' Clinical Data Collection' section, did the authors mean ulcerative colitis or Crohn's
disease?
5. Which instrument for food intake collection was used to calculate the DII? Please add this
information.
6. Why were fecal calprotectin measurements not performed?
7. Which statistical test was employed to assess the normality of the distribution?
8. Please provide the meaning of the acronym 'M' in the 'Statistical Analysis' section.
9. Please verify the names of the biologic agents in Table 1.
10. Why did the authors categorize patients in remission with mild disease rather than comparing
remission versus activity (mild, moderate, and severe)? The difference in the number of patients
in each group was significant - 183 versus 85.
11. Figure legends: Please provide the meanings of all acronyms appearing in the figures.
12. Discussion - The Importance of Physical Activity: I suggest removing the word 'prevention'
from the fourth line.
13. Discussion - Impact of Dietary Inflammatory Index on Disease Activity in CD Patients: I
suggest changing ‘CD patients are encouraged to increase their intake of foods rich in vitamin
C and vitamin D’ to ‘CD patients are encouraged to increase their intake of fruits, vegetables
and omega-3-fatty acids’.
14. Discussion - Impact of Dietary Inflammatory Index on Disease Activity in CD Patients:
Please add and discuss studies on the effects of the DII in CD.
Please review this paper.
user
Title: Influential Factors on Disease Activity in Crohn's Disease and Their ROC Curve
Evaluation: A Cross-Sectional Study
Version: 3 Date: 25 Jan 2024
Reviewer's report:
The manuscript addresses a pertinent topic regarding factors affecting CD patients. The study
included a substantial number of participants (n=268); however, only clinical evaluation of the
disease was carried out. Therefore, I have some comments and suggestions to make:
1. Abstract section: In the conclusion, the authors repeat the findings presented in the results.
I suggest changing the conclusion.
2. Introduction section: The anti-inflammatory diet is among the various diets suggested for
managing patients with CD. Despite demonstrating certain positive effects, there is no clear
recommendation for selecting a specific diet in the context of CD. Please rephrase the sentence.
3. Please add the diagnostic criteria established by the Chinese Society of Gastroenterology in
the 'Study Population' section.
4. In the' Clinical Data Collection' section, did the authors mean ulcerative colitis or Crohn's
disease?
5. Which instrument for food intake collection was used to calculate the DII? Please add this
information.
6. Why were fecal calprotectin measurements not performed?
7. Which statistical test was employed to assess the normality of the distribution?
8. Please provide the meaning of the acronym 'M' in the 'Statistical Analysis' section.
9. Please verify the names of the biologic agents in Table 1.
10. Why did the authors categorize patients in remission with mild disease rather than comparing
remission versus activity (mild, moderate, and severe)? The difference in the number of patients
in each group was significant - 183 versus 85.
11. Figure legends: Please provide the meanings of all acronyms appearing in the figures.
12. Discussion - The Importance of Physical Activity: I suggest removing the word 'prevention'
from the fourth line.
13. Discussion - Impact of Dietary Inflammatory Index on Disease Activity in CD Patients: I
suggest changing ‘CD patients are encouraged to increase their intake of foods rich in vitamin
C and vitamin D’ to ‘CD patients are encouraged to increase their intake of fruits, vegetables
and omega-3-fatty acids’.
14. Discussion - Impact of Dietary Inflammatory Index on Disease Activity in CD Patients:
Please add and discuss studies on the effects of the DII in CD.
assistant