Title: The Impact of Serum Neuregulin 4 (NRG#4) Levels on Non-Alcoholic Fatty Liver
Disease (NAFLD): A Systematic Review and Meta-Analysis
Version: 3 Date: 25 Mar 2025
Reviewer's report:
Thank you for the submitted manuscript. I have a few points that need to be addressed:
1. Since the systematic search was conducted in 2023, please update the search.
2. Please describe the search strategy for each database either in the main text or in the
supplementary materials.
3. In the data extraction section, there are explanations regarding unit conversions that should
be moved to the statistical analysis section.
4. In the statistical analysis section, the approach regarding potential publication bias has not
been mentioned.
5. The statistical analysis section lacks explanations for the choice of fixed-effects model instead
of random-effect model, as heterogenity is reported high in results.
6. In the results section, line 216 mentions that one of the studies was excluded due to a poor
effect size. Was a sensitivity analysis conducted for this exclusion?
7. The results of publication bias is not mentioned in the study.
8. The manuscript requires revision in terms of scientific writing.
Title: The Impact of Serum Neuregulin 4 (NRG#4) Levels on Non-Alcoholic Fatty Liver
Disease (NAFLD): A Systematic Review and Meta-Analysis
Version: 3 Date: 25 Mar 2025
Reviewer's report:
Thank you for the submitted manuscript. I have a few points that need to be addressed:
1. Since the systematic search was conducted in 2023, please update the search.
2. Please describe the search strategy for each database either in the main text or in the
supplementary materials.
3. In the data extraction section, there are explanations regarding unit conversions that should
be moved to the statistical analysis section.
4. In the statistical analysis section, the approach regarding potential publication bias has not
been mentioned.
5. The statistical analysis section lacks explanations for the choice of fixed-effects model instead
of random-effect model, as heterogenity is reported high in results.
6. In the results section, line 216 mentions that one of the studies was excluded due to a poor
effect size. Was a sensitivity analysis conducted for this exclusion?
7. The results of publication bias is not mentioned in the study.
8. The manuscript requires revision in terms of scientific writing.
Please review this paper.
user
Title: The Impact of Serum Neuregulin 4 (NRG#4) Levels on Non-Alcoholic Fatty Liver
Disease (NAFLD): A Systematic Review and Meta-Analysis
Version: 3 Date: 25 Mar 2025
Reviewer's report:
Thank you for the submitted manuscript. I have a few points that need to be addressed:
1. Since the systematic search was conducted in 2023, please update the search.
2. Please describe the search strategy for each database either in the main text or in the
supplementary materials.
3. In the data extraction section, there are explanations regarding unit conversions that should
be moved to the statistical analysis section.
4. In the statistical analysis section, the approach regarding potential publication bias has not
been mentioned.
5. The statistical analysis section lacks explanations for the choice of fixed-effects model instead
of random-effect model, as heterogenity is reported high in results.
6. In the results section, line 216 mentions that one of the studies was excluded due to a poor
effect size. Was a sensitivity analysis conducted for this exclusion?
7. The results of publication bias is not mentioned in the study.
8. The manuscript requires revision in terms of scientific writing.
assistant