Reviewer ’s report  
 
Title: Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF -1 and IGF -binding  
Protein 2 in Morbidly Obese Patients  
 
Version: 0 Date: 25 Jan 2020  
 
Reviewer: Mirto Foletto  
 
Reviewer's report:  
 
The topic is really interesting but the way it is reported needs mo re in terms of language, 
concept, results.  
 
Abstract: the results session is too "messy" and should be limited to relevant data.  
 
Introduction: page 4 line 20: BMI cannot measure body fat. To be amended in the text  
 
line 30: It is produced ... It is not clear  whether this is referred either to GH or GH and IGF -1 
 
page 5 line 9: IGFBP -2 ... unclear  
 
line 37 -42: However, there ... unclear, maybe something's missing in the sentence  
 
Discussion is too "sketchy" and should be explained the apparent contradi ction between the 
increase of Cholesterol and opposite and beneficial effects of bariatric surgery, such as reduction 
of insulin resistance and so on  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to t he authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I dec lare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be includ ed 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF -1 and IGF -binding  
Protein 2 in Morbidly Obese Patients  
 
Version: 0 Date: 25 Jan 2020  
 
Reviewer: Mirto Foletto  
 
Reviewer's report:  
 
The topic is really interesting but the way it is reported needs mo re in terms of language, 
concept, results.  
 
Abstract: the results session is too "messy" and should be limited to relevant data.  
 
Introduction: page 4 line 20: BMI cannot measure body fat. To be amended in the text  
 
line 30: It is produced ... It is not clear  whether this is referred either to GH or GH and IGF -1 
 
page 5 line 9: IGFBP -2 ... unclear  
 
line 37 -42: However, there ... unclear, maybe something's missing in the sentence  
 
Discussion is too "sketchy" and should be explained the apparent contradi ction between the 
increase of Cholesterol and opposite and beneficial effects of bariatric surgery, such as reduction 
of insulin resistance and so on  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to t he authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I dec lare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be includ ed 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Effects of Gastric Sleeve Surgery on the Serum Levels of GH, IGF -1 and IGF -binding  
Protein 2 in Morbidly Obese Patients  
 
Version: 0 Date: 25 Jan 2020  
 
Reviewer: Mirto Foletto  
 
Reviewer's report:  
 
The topic is really interesting but the way it is reported needs mo re in terms of language, 
concept, results.  
 
Abstract: the results session is too "messy" and should be limited to relevant data.  
 
Introduction: page 4 line 20: BMI cannot measure body fat. To be amended in the text  
 
line 30: It is produced ... It is not clear  whether this is referred either to GH or GH and IGF -1 
 
page 5 line 9: IGFBP -2 ... unclear  
 
line 37 -42: However, there ... unclear, maybe something's missing in the sentence  
 
Discussion is too "sketchy" and should be explained the apparent contradi ction between the 
increase of Cholesterol and opposite and beneficial effects of bariatric surgery, such as reduction 
of insulin resistance and so on  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
No 
 
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to t he authors.  
 
Unable to assess  
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspects require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscr ipt: 
 
Not suitable for publication unless extensively edited  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, fund ing, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, either now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that  
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, w rite 'I declare that I have no competing interests' 
below.  If your reply is yes to any, please give details below.  
 
I dec lare that I have no competing interests  
 
I agree to the open peer review policy of the journal. I understand that my name will be includ ed 
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant