Reviewer ’s report  
 
Title: Case Report of Patient with Cronkhite -Canada Syndrome: Sustained Remission after 
Treatment with Corticosteroids and Mesalazine  
 
Version: 0 Date: 01 Dec 2018  
 
Reviewer: Mikaell Alexandre Gouvea Faria  
 
Reviewer's report:  
 
Dears authors,  
 
The present work may contribute to the medical literature on one more case to compose the 
incidence and prevalence of Cronkhite Canada  syndrome, however, it is necessary that the 
authors make some corrections that are listed below:  
- Standardize with a decimal place all the numbers that appear in all text;  
 
- In the background chapter, it is necessary to remove the explanation of what Cr onkhite 
Canada syndrome is, and instead to put data on the incidence and prevalence of this disease. I 
would like to inform you that the authors presented these data in the "discussion" chapter, so 
I encourage the authors to remove these data from the "dis cussion" and direct them as the 
first chapter of the introduction;  
 
- Corrections must be made in English in all text.  
 
- Remove the equal signs (:) that have been placed in the title of each chapter, for example: 
"Background:". Also, remove the underscore.  
 
- It is necessary to add more paragraphs in the "Background" chapter, at least around 2 to 3 
paragraphs;  
 
- In the item "Keywords" it is necessary to put an end point after each word.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
  
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data s hown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspect s require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, eit her now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If you r reply is yes to any, please give details below.  
 
I declare tha t I have no competing interests . 
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including  any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any c omments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Case Report of Patient with Cronkhite -Canada Syndrome: Sustained Remission after 
Treatment with Corticosteroids and Mesalazine  
 
Version: 0 Date: 01 Dec 2018  
 
Reviewer: Mikaell Alexandre Gouvea Faria  
 
Reviewer's report:  
 
Dears authors,  
 
The present work may contribute to the medical literature on one more case to compose the 
incidence and prevalence of Cronkhite Canada  syndrome, however, it is necessary that the 
authors make some corrections that are listed below:  
- Standardize with a decimal place all the numbers that appear in all text;  
 
- In the background chapter, it is necessary to remove the explanation of what Cr onkhite 
Canada syndrome is, and instead to put data on the incidence and prevalence of this disease. I 
would like to inform you that the authors presented these data in the "discussion" chapter, so 
I encourage the authors to remove these data from the "dis cussion" and direct them as the 
first chapter of the introduction;  
 
- Corrections must be made in English in all text.  
 
- Remove the equal signs (:) that have been placed in the title of each chapter, for example: 
"Background:". Also, remove the underscore.  
 
- It is necessary to add more paragraphs in the "Background" chapter, at least around 2 to 3 
paragraphs;  
 
- In the item "Keywords" it is necessary to put an end point after each word.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
  
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data s hown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspect s require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, eit her now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If you r reply is yes to any, please give details below.  
 
I declare tha t I have no competing interests . 
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including  any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any c omments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Case Report of Patient with Cronkhite -Canada Syndrome: Sustained Remission after 
Treatment with Corticosteroids and Mesalazine  
 
Version: 0 Date: 01 Dec 2018  
 
Reviewer: Mikaell Alexandre Gouvea Faria  
 
Reviewer's report:  
 
Dears authors,  
 
The present work may contribute to the medical literature on one more case to compose the 
incidence and prevalence of Cronkhite Canada  syndrome, however, it is necessary that the 
authors make some corrections that are listed below:  
- Standardize with a decimal place all the numbers that appear in all text;  
 
- In the background chapter, it is necessary to remove the explanation of what Cr onkhite 
Canada syndrome is, and instead to put data on the incidence and prevalence of this disease. I 
would like to inform you that the authors presented these data in the "discussion" chapter, so 
I encourage the authors to remove these data from the "dis cussion" and direct them as the 
first chapter of the introduction;  
 
- Corrections must be made in English in all text.  
 
- Remove the equal signs (:) that have been placed in the title of each chapter, for example: 
"Background:". Also, remove the underscore.  
 
- It is necessary to add more paragraphs in the "Background" chapter, at least around 2 to 3 
paragraphs;  
 
- In the item "Keywords" it is necessary to put an end point after each word.  
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
  
Does the work include the necessary controls?  
If not, please specify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data s hown?  
If not, please explain in your comments to the authors.  
 
Yes 
 
Are you able to assess any statistics in the manuscript or would you recommend an  
additional statistical review?  
If an additional statistical review is recommended, please specify what aspect s require further  
assessment in your comments to the editors.  
 
Not relevant to this manuscript  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Needs some language corrections before being published  
 
Declaration of competing interests  
Please complete a declaration of competing interests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, fees, funding, or salary from an  
organisation that may in any way gain or lose financially from the publication of this  
manuscript, eit her now or in the future?  
 
2. Do you hold any stocks or shares in an organisation that may in any way gain or lose  
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to the content of the  
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds  or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do you have any non -financial competing interests in relation to this paper?  
 
If you can answer no to all of the above, write 'I declare that I have no competing interests' 
below.  If you r reply is yes to any, please give details below.  
 
I declare tha t I have no competing interests . 
 
I agree to the open peer review policy of the journal. I understand that my name will be included  
on my report to the authors and, if the manuscript is accepted for publication, my named report  
including  any attachments I upload will be posted on the website along with the authors'  
responses. I agree for my report to be made available under an Open Access Creative Commons  
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any c omments  
which I do not wish to be included in my named report can be included as confidential comments  
to the editors, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant