Title: CT enterography for evaluation of disease activity in patients with ileocolonic Crohn's
disease
Version: 1 Date: 20 Jan 2022
Reviewer:  Ilhami Yuksel
Reviewer's report:
The present study aimed to develop a quantitative CTE scoring system in detecting disease
activity of ileocolonic CD based on ileocolonoscopy.
However, several major points should be addressed by the Authors.
Major points:
The Authors used ileocolonoscopy as reference standard for detecting CD activity and they used
Crohn's disease endoscopic index of severity (CDEIS) for this purpose. But CDEIS cut-off value
was not given to define endoscopic remission or activation.
The Authors used the presence of an endoscopic lesions and the presence of ulcers at endoscopy
rather than CDEIS as a predictive markers to determine CTE activity score.
The Authors should address sub-score of the CDEIS by using standard cut-off value for each
evaluating ileal and colonic segments. The Authors must compare between sub-score of the
CDEIS and CTE parameters, because statistic analysis was applied for assessing the association
between CDEIS and CTE variables in the present study. New statistic analysis should be done
according to current standard definition of CDEIS.
Finally current results should be rewritten and discussed in the text.
Title: CT enterography for evaluation of disease activity in patients with ileocolonic Crohn's
disease
Version: 1 Date: 20 Jan 2022
Reviewer:  Ilhami Yuksel
Reviewer's report:
The present study aimed to develop a quantitative CTE scoring system in detecting disease
activity of ileocolonic CD based on ileocolonoscopy.
However, several major points should be addressed by the Authors.
Major points:
The Authors used ileocolonoscopy as reference standard for detecting CD activity and they used
Crohn's disease endoscopic index of severity (CDEIS) for this purpose. But CDEIS cut-off value
was not given to define endoscopic remission or activation.
The Authors used the presence of an endoscopic lesions and the presence of ulcers at endoscopy
rather than CDEIS as a predictive markers to determine CTE activity score.
The Authors should address sub-score of the CDEIS by using standard cut-off value for each
evaluating ileal and colonic segments. The Authors must compare between sub-score of the
CDEIS and CTE parameters, because statistic analysis was applied for assessing the association
between CDEIS and CTE variables in the present study. New statistic analysis should be done
according to current standard definition of CDEIS.
Finally current results should be rewritten and discussed in the text.
Please review this paper.
user
Title: CT enterography for evaluation of disease activity in patients with ileocolonic Crohn's
disease
Version: 1 Date: 20 Jan 2022
Reviewer:  Ilhami Yuksel
Reviewer's report:
The present study aimed to develop a quantitative CTE scoring system in detecting disease
activity of ileocolonic CD based on ileocolonoscopy.
However, several major points should be addressed by the Authors.
Major points:
The Authors used ileocolonoscopy as reference standard for detecting CD activity and they used
Crohn's disease endoscopic index of severity (CDEIS) for this purpose. But CDEIS cut-off value
was not given to define endoscopic remission or activation.
The Authors used the presence of an endoscopic lesions and the presence of ulcers at endoscopy
rather than CDEIS as a predictive markers to determine CTE activity score.
The Authors should address sub-score of the CDEIS by using standard cut-off value for each
evaluating ileal and colonic segments. The Authors must compare between sub-score of the
CDEIS and CTE parameters, because statistic analysis was applied for assessing the association
between CDEIS and CTE variables in the present study. New statistic analysis should be done
according to current standard definition of CDEIS.
Finally current results should be rewritten and discussed in the text.
assistant