Title: Is empiric proton pump inhibition in patients with symptoms of extraesophageal
gastroesophageal reflux justified?
Version: 1 Date: 17 Jul 2023
Reviewer:  Frank Zerbib
Reviewer's report:
This is an excellent overview on this difficult topic. I fully agree with the message of this
manuscript, which appears to be well balanced. My only suggestion would be
- to give the definition of the so called "LPR" as initially developed by the ENT specialists and
show that there is nothing objective
- to  give a little more details on the techniques developped to detect reflux in the pharynx. These
techniques are not reliable (cf Restech) or, even though validated by some groups, did not show
significant/abnormal pharyngeal reflux. examples of ref:
1 Neurogastroenterol Motil. 2017 Jan;29(1). doi: 10.1111/nmo.12909. Epub 2016 Jul 18. PMID:
27424517
2 Clin Gastroenterol Hepatol. 2018 Jul;16(7):1018-1029. doi: 10.1016/j.cgh.2018.02.001. Epub
2018 Feb 7. PMID: 29427733.
Title: Is empiric proton pump inhibition in patients with symptoms of extraesophageal
gastroesophageal reflux justified?
Version: 1 Date: 17 Jul 2023
Reviewer:  Frank Zerbib
Reviewer's report:
This is an excellent overview on this difficult topic. I fully agree with the message of this
manuscript, which appears to be well balanced. My only suggestion would be
- to give the definition of the so called "LPR" as initially developed by the ENT specialists and
show that there is nothing objective
- to  give a little more details on the techniques developped to detect reflux in the pharynx. These
techniques are not reliable (cf Restech) or, even though validated by some groups, did not show
significant/abnormal pharyngeal reflux. examples of ref:
1 Neurogastroenterol Motil. 2017 Jan;29(1). doi: 10.1111/nmo.12909. Epub 2016 Jul 18. PMID:
27424517
2 Clin Gastroenterol Hepatol. 2018 Jul;16(7):1018-1029. doi: 10.1016/j.cgh.2018.02.001. Epub
2018 Feb 7. PMID: 29427733.
Please review this paper.
user
Title: Is empiric proton pump inhibition in patients with symptoms of extraesophageal
gastroesophageal reflux justified?
Version: 1 Date: 17 Jul 2023
Reviewer:  Frank Zerbib
Reviewer's report:
This is an excellent overview on this difficult topic. I fully agree with the message of this
manuscript, which appears to be well balanced. My only suggestion would be
- to give the definition of the so called "LPR" as initially developed by the ENT specialists and
show that there is nothing objective
- to  give a little more details on the techniques developped to detect reflux in the pharynx. These
techniques are not reliable (cf Restech) or, even though validated by some groups, did not show
significant/abnormal pharyngeal reflux. examples of ref:
1 Neurogastroenterol Motil. 2017 Jan;29(1). doi: 10.1111/nmo.12909. Epub 2016 Jul 18. PMID:
27424517
2 Clin Gastroenterol Hepatol. 2018 Jul;16(7):1018-1029. doi: 10.1016/j.cgh.2018.02.001. Epub
2018 Feb 7. PMID: 29427733.
assistant