Reviewer's report
Title:Peroxisome Proliferators-Activated Alpha Agonist Treatment Improves
Hepatic Damage in Rats with Obstructive Jaundice: An Experimental Study
Version: 3Date:10 July 2007
Reviewer: Olivier Barbier
Reviewer's report:
The manuscript has been greatly improved, and I have only minor comments:
- p7, 23rd paragraph: "betwenn BDL and BDL-vehicle"; the term control is
confusing with the sham controls
- pp 7,8,9,10: The term "PPARa induced or induction" is inappropriate. It would
be better to mention PPARa activated or activation. Induction relates to the
PPARa gene expression, which is not concern in the present study.
- p7: total in bold in the first paragraph of the result section.
- p8: It would have been interesting that the authors further discussed their
observation that "fenofibrate has regenerative effects".
- p9: "PPARa agonists activate..."
- p10: "obstructive jaundice affect..."
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Peroxisome Proliferators-Activated Alpha Agonist Treatment Improves
Hepatic Damage in Rats with Obstructive Jaundice: An Experimental Study
Version: 3Date:10 July 2007
Reviewer: Olivier Barbier
Reviewer's report:
The manuscript has been greatly improved, and I have only minor comments:
- p7, 23rd paragraph: "betwenn BDL and BDL-vehicle"; the term control is
confusing with the sham controls
- pp 7,8,9,10: The term "PPARa induced or induction" is inappropriate. It would
be better to mention PPARa activated or activation. Induction relates to the
PPARa gene expression, which is not concern in the present study.
- p7: total in bold in the first paragraph of the result section.
- p8: It would have been interesting that the authors further discussed their
observation that "fenofibrate has regenerative effects".
- p9: "PPARa agonists activate..."
- p10: "obstructive jaundice affect..."
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Peroxisome Proliferators-Activated Alpha Agonist Treatment Improves
Hepatic Damage in Rats with Obstructive Jaundice: An Experimental Study
Version: 3Date:10 July 2007
Reviewer: Olivier Barbier
Reviewer's report:
The manuscript has been greatly improved, and I have only minor comments:
- p7, 23rd paragraph: "betwenn BDL and BDL-vehicle"; the term control is
confusing with the sham controls
- pp 7,8,9,10: The term "PPARa induced or induction" is inappropriate. It would
be better to mention PPARa activated or activation. Induction relates to the
PPARa gene expression, which is not concern in the present study.
- p7: total in bold in the first paragraph of the result section.
- p8: It would have been interesting that the authors further discussed their
observation that "fenofibrate has regenerative effects".
- p9: "PPARa agonists activate..."
- p10: "obstructive jaundice affect..."
What next?: Accept after minor essential revisions
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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