Reviewer's report
Title:Effects of Cystalloids and Colloids on liver and intestine microcirculation
and function in CLP-induced septic rodents
Version: 2Date:16 August 2012
Reviewer: Jonel Trebicka
Reviewer's report:
General comments
This study addresses an important issue in critical care medicine. It shows nicely
tah cristaloids might be the right choice for volume resuscitation during sepsis.
Furthermore the authors demonstrate that the inflammatory response was
aggravated using volume resuscitation other than crystaloiods.
Even though this study is important and clinically significant, several points
should be considered
Major Compulsory Revisions
1. the model of sepsis is a peritonitis model, do the authors think that an other
model would deliver similar results, e.g. bacterial tracheal injection, since
respiratory infections are usual cause of sepsis in humans? this point should at
least be discussed
2. the authors show hepatic microcirculation but do not show portal pressure. did
tehy measure it? can the authors speculate on the effect of volume resuscitation
on pressure?
3. what about renal function do the authros have any data on that, renal
perfusion, urine output or creatinin/BUN values?
4. eventhough the discussion is pretty long (should be improved) little hypothesis
are discussed why HES or Gel are worse than crystaloid in survival?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interest
Reviewer's report
Title:Effects of Cystalloids and Colloids on liver and intestine microcirculation
and function in CLP-induced septic rodents
Version: 2Date:16 August 2012
Reviewer: Jonel Trebicka
Reviewer's report:
General comments
This study addresses an important issue in critical care medicine. It shows nicely
tah cristaloids might be the right choice for volume resuscitation during sepsis.
Furthermore the authors demonstrate that the inflammatory response was
aggravated using volume resuscitation other than crystaloiods.
Even though this study is important and clinically significant, several points
should be considered
Major Compulsory Revisions
1. the model of sepsis is a peritonitis model, do the authors think that an other
model would deliver similar results, e.g. bacterial tracheal injection, since
respiratory infections are usual cause of sepsis in humans? this point should at
least be discussed
2. the authors show hepatic microcirculation but do not show portal pressure. did
tehy measure it? can the authors speculate on the effect of volume resuscitation
on pressure?
3. what about renal function do the authros have any data on that, renal
perfusion, urine output or creatinin/BUN values?
4. eventhough the discussion is pretty long (should be improved) little hypothesis
are discussed why HES or Gel are worse than crystaloid in survival?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interest
Please review this paper.
user
Reviewer's report
Title:Effects of Cystalloids and Colloids on liver and intestine microcirculation
and function in CLP-induced septic rodents
Version: 2Date:16 August 2012
Reviewer: Jonel Trebicka
Reviewer's report:
General comments
This study addresses an important issue in critical care medicine. It shows nicely
tah cristaloids might be the right choice for volume resuscitation during sepsis.
Furthermore the authors demonstrate that the inflammatory response was
aggravated using volume resuscitation other than crystaloiods.
Even though this study is important and clinically significant, several points
should be considered
Major Compulsory Revisions
1. the model of sepsis is a peritonitis model, do the authors think that an other
model would deliver similar results, e.g. bacterial tracheal injection, since
respiratory infections are usual cause of sepsis in humans? this point should at
least be discussed
2. the authors show hepatic microcirculation but do not show portal pressure. did
tehy measure it? can the authors speculate on the effect of volume resuscitation
on pressure?
3. what about renal function do the authros have any data on that, renal
perfusion, urine output or creatinin/BUN values?
4. eventhough the discussion is pretty long (should be improved) little hypothesis
are discussed why HES or Gel are worse than crystaloid in survival?
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
No competing interest
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