Reviewer ’s report  
 
Title: Helicobacter pylori Infection Progresses Proximally Associ ated with Pyloric Metaplasia in 
Age-dependent Tendency: A Cross -Sectional Study  
 
Version: 0 Date: 19 Aug 2018  
 
Reviewer: Quadri Alabi  
 
Reviewer's report:  
 
The review reports on Helicobacter pylori Infection Progresses Proximally Associated with 
Pyloric Metaplasia in Age -dependent Tendency: A Cross -Sectional Study by Huiying Shi, 
Hanhua Xiong, and Wei Qian, Rong Lin .  
 
 
The study is  well presented and give brief details of correlation of Helicobacter pylori infection 
in different region of the stomach of young, mid -age and old age patients with dyspepsia.  
 
 
In the methods, authors should indicate the geographical location. The locatio n where the study 
was conducted.  
 
 
Authors should create a limitation section for these:Even though there is the potential bias due to 
time-cohort effect with different environmental factors exposed among different age groups, the 
positive association among H. pylori colonization and pyloric metaplasia is demonstrated within 
each age group. Further clinical trials evaluating the effect of eradication of H. pylori infection 
on the pyloric metaplasia process are now needed to further understand.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please spe cify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or w ould you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
 
 
Declaration of competing interests  
Please complete a declaration of competing in terests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in t he future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to th e content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do y ou have any non -financial competing interests in relation to this paper?  
 
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests'  
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interest  
 
I agree to the open pe er review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the auth ors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be includ ed as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
Reviewer ’s report  
 
Title: Helicobacter pylori Infection Progresses Proximally Associ ated with Pyloric Metaplasia in 
Age-dependent Tendency: A Cross -Sectional Study  
 
Version: 0 Date: 19 Aug 2018  
 
Reviewer: Quadri Alabi  
 
Reviewer's report:  
 
The review reports on Helicobacter pylori Infection Progresses Proximally Associated with 
Pyloric Metaplasia in Age -dependent Tendency: A Cross -Sectional Study by Huiying Shi, 
Hanhua Xiong, and Wei Qian, Rong Lin .  
 
 
The study is  well presented and give brief details of correlation of Helicobacter pylori infection 
in different region of the stomach of young, mid -age and old age patients with dyspepsia.  
 
 
In the methods, authors should indicate the geographical location. The locatio n where the study 
was conducted.  
 
 
Authors should create a limitation section for these:Even though there is the potential bias due to 
time-cohort effect with different environmental factors exposed among different age groups, the 
positive association among H. pylori colonization and pyloric metaplasia is demonstrated within 
each age group. Further clinical trials evaluating the effect of eradication of H. pylori infection 
on the pyloric metaplasia process are now needed to further understand.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please spe cify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or w ould you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
 
 
Declaration of competing interests  
Please complete a declaration of competing in terests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in t he future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to th e content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do y ou have any non -financial competing interests in relation to this paper?  
 
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests'  
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interest  
 
I agree to the open pe er review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the auth ors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be includ ed as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
Please review this paper.
user
Reviewer ’s report  
 
Title: Helicobacter pylori Infection Progresses Proximally Associ ated with Pyloric Metaplasia in 
Age-dependent Tendency: A Cross -Sectional Study  
 
Version: 0 Date: 19 Aug 2018  
 
Reviewer: Quadri Alabi  
 
Reviewer's report:  
 
The review reports on Helicobacter pylori Infection Progresses Proximally Associated with 
Pyloric Metaplasia in Age -dependent Tendency: A Cross -Sectional Study by Huiying Shi, 
Hanhua Xiong, and Wei Qian, Rong Lin .  
 
 
The study is  well presented and give brief details of correlation of Helicobacter pylori infection 
in different region of the stomach of young, mid -age and old age patients with dyspepsia.  
 
 
In the methods, authors should indicate the geographical location. The locatio n where the study 
was conducted.  
 
 
Authors should create a limitation section for these:Even though there is the potential bias due to 
time-cohort effect with different environmental factors exposed among different age groups, the 
positive association among H. pylori colonization and pyloric metaplasia is demonstrated within 
each age group. Further clinical trials evaluating the effect of eradication of H. pylori infection 
on the pyloric metaplasia process are now needed to further understand.  
 
 
 
Are the methods appropriate and well described?  
If not, please specify what is required in your comments to the authors.  
 
Yes 
 
Does the work include the necessary controls?  
If not, please spe cify which controls are required in your comments to the authors.  
 
Yes 
 
Are the conclusions drawn adequately supported by the data shown?  
If not, please explain in your comments to the authors.  
 
Yes 
Are you able to assess any statistics in the manuscript or w ould you recommend an 
additional statistical review?  
If an additional statistical review is recommended, please speci fy what aspects require further 
assessment in your comments to the editors.  
 
I am able to assess the statistics  
 
Quality of written English  
Please indicate the quality of language in the manuscript:  
 
Acceptable  
 
 
 
Declaration of competing interests  
Please complete a declaration of competing in terests, considering the following questions:  
 
1. Have you in the past five years received reimbursements, f ees, funding, or salary from an 
organisation that may in any way gain or lose financial ly from the publication of this 
manuscript, either now or in t he future?  
 
2. Do you hold any stocks or shares in an organisation t hat may in any way gain or lose 
financially from the publication of this manuscript, either now or in the future?  
 
3. Do you hold or are you currently applying for any patents relating to th e content of the 
manuscript?  
 
4. Have you received reimbursements, fees, funding, or salary from an organization that 
holds or has applied for patents relating to the content of the manuscript?  
 
5. Do you have any other financial competing interests?  
 
6. Do y ou have any non -financial competing interests in relation to this paper?  
 
 
If you can answer no to all of the above, write 'I declare that I have  no competing interests'  
below. If your reply is yes to any, please give details below.  
 
I declare that I have no competing interest  
 
I agree to the open pe er review policy of the journal. I understan d that my name will be included 
on my report to the authors and, if the manuscript is accepted f or publication, my named report 
including any attachments I upload will be posted on the website along with the auth ors' 
responses. I agree for my report to be made available under an Open Access Creative Commons 
CC-BY license ( http://creativecommons.org/licenses/by/4.0/ ). I understand that any comments 
which I do not wish to be included in my named report can be includ ed as confidential comments 
to the editor s, which will not be published.  
 
I agree to the open peer review policy of the journal  
assistant