Reviewer's report
Title:Cronkhite-Canada syndrome associated with rib fracture: a case report.
Version: 1Date:1 June 2010
Reviewer: Atsushi Irisawa
Reviewer's report:
CCS is interesting disease that has various kind of concominant disease.
I read fascinatingly your manuscript, but it was totally lack of essential data that
suggest direct association between CCS and rib fracture. Both lesions seemed to
just incidentally happen at same time.
I wrote each item below that you should add before your manuscript will be
reconsidered to be accepted.
1. You should add laboratory data on admission and changes after treatment.
2. I would like to know in detail about the etiology of rib fracture. First, did you
check bone metastasis, especially osteolytic bone metastases that are not
sensitive for bone scan? Negative data of bone scan did not guaranty absence of
bone metastases.
Second, you should add hormonal examination. As you know, there are many
hormone and substances associated with bone metabolism.
Third, how about bone densitometry on vertebrae lumbales or caput femoris?
Last, why you did not consider surgical treatment? In this case, you used
corticosteroid that will have harm effect for bone healing. In some patients of
CCS, steroid is used for life long. Then, you should consult to orthopedic surgeon
the bone management.
3. Did he have any medical history of congenital disease, for example
Osteogenesis imperfecta? His general appearance will be helpful for speculation.
Reviewer's report
Title:Cronkhite-Canada syndrome associated with rib fracture: a case report.
Version: 1Date:1 June 2010
Reviewer: Atsushi Irisawa
Reviewer's report:
CCS is interesting disease that has various kind of concominant disease.
I read fascinatingly your manuscript, but it was totally lack of essential data that
suggest direct association between CCS and rib fracture. Both lesions seemed to
just incidentally happen at same time.
I wrote each item below that you should add before your manuscript will be
reconsidered to be accepted.
1. You should add laboratory data on admission and changes after treatment.
2. I would like to know in detail about the etiology of rib fracture. First, did you
check bone metastasis, especially osteolytic bone metastases that are not
sensitive for bone scan? Negative data of bone scan did not guaranty absence of
bone metastases.
Second, you should add hormonal examination. As you know, there are many
hormone and substances associated with bone metabolism.
Third, how about bone densitometry on vertebrae lumbales or caput femoris?
Last, why you did not consider surgical treatment? In this case, you used
corticosteroid that will have harm effect for bone healing. In some patients of
CCS, steroid is used for life long. Then, you should consult to orthopedic surgeon
the bone management.
3. Did he have any medical history of congenital disease, for example
Osteogenesis imperfecta? His general appearance will be helpful for speculation.
Please review this paper.
user
Reviewer's report
Title:Cronkhite-Canada syndrome associated with rib fracture: a case report.
Version: 1Date:1 June 2010
Reviewer: Atsushi Irisawa
Reviewer's report:
CCS is interesting disease that has various kind of concominant disease.
I read fascinatingly your manuscript, but it was totally lack of essential data that
suggest direct association between CCS and rib fracture. Both lesions seemed to
just incidentally happen at same time.
I wrote each item below that you should add before your manuscript will be
reconsidered to be accepted.
1. You should add laboratory data on admission and changes after treatment.
2. I would like to know in detail about the etiology of rib fracture. First, did you
check bone metastasis, especially osteolytic bone metastases that are not
sensitive for bone scan? Negative data of bone scan did not guaranty absence of
bone metastases.
Second, you should add hormonal examination. As you know, there are many
hormone and substances associated with bone metabolism.
Third, how about bone densitometry on vertebrae lumbales or caput femoris?
Last, why you did not consider surgical treatment? In this case, you used
corticosteroid that will have harm effect for bone healing. In some patients of
CCS, steroid is used for life long. Then, you should consult to orthopedic surgeon
the bone management.
3. Did he have any medical history of congenital disease, for example
Osteogenesis imperfecta? His general appearance will be helpful for speculation.
assistant