Title: Clinical Characteristic and Pathogenesis of Tumor-Induced Acute Pancreatitis: A
Predictive Model
Version: 1 Date: 26 Jul 2022
Reviewer's report:
The authors carry out a prospective study to determine the clinical characteristics and
pathogenesis of tumor-induced acute pancreatitis, and to develop a reliable prediction model of
the clinical features to guide the diagnosis and treatment.
Congratulations to the authors for having be able to carry out this study that shows significant
differences between groups (tumor vs non-tumor) and predictive factors which may lead to
improve the clinical suspicion of these patients. This is an interesting a well-written manuscript.
It has a few minor issues and some points of clarity from the authors would be helpful. Can you
explain these points better?
1. "360 admissions were random selected from those AP patients with other etiologies as the
non-tumor group".  I think that you have explained this part, because it will be  a cause of bias.
Explain the election criteria.
2. "aggravated intense pain in the upper abdomen was special symptoms of 88 patients". If
this is a retrospective study, how was pain intensity measured in all patients? Do you have this
measurement in each patient's clinical history? Was the same scale used for all?
3. "median cost of the tumor group was more", What cost parameters were evaluated? hospital
stay? treatments? interventions? oncological surgery? only AP cost?
4. "The sensitivities of CT, US, MRCP, EUS and PET-CT were 97.7%(85/87), 84.1%(58/69),
95.7%(45/47), 100%(9/9) and 81.8%(9/11)". The sensitivity for the diagnosis of what? All
patients underwent to all diagnosis studies?  How did they find the sensitivity of diagnostic
studies?
5. There are studies said Acute Pancreatitis can be a early marker of pancreatic cancer, for this
reason, it is a disappointment not to have the stage of the tumors.
Title: Clinical Characteristic and Pathogenesis of Tumor-Induced Acute Pancreatitis: A
Predictive Model
Version: 1 Date: 26 Jul 2022
Reviewer's report:
The authors carry out a prospective study to determine the clinical characteristics and
pathogenesis of tumor-induced acute pancreatitis, and to develop a reliable prediction model of
the clinical features to guide the diagnosis and treatment.
Congratulations to the authors for having be able to carry out this study that shows significant
differences between groups (tumor vs non-tumor) and predictive factors which may lead to
improve the clinical suspicion of these patients. This is an interesting a well-written manuscript.
It has a few minor issues and some points of clarity from the authors would be helpful. Can you
explain these points better?
1. "360 admissions were random selected from those AP patients with other etiologies as the
non-tumor group".  I think that you have explained this part, because it will be  a cause of bias.
Explain the election criteria.
2. "aggravated intense pain in the upper abdomen was special symptoms of 88 patients". If
this is a retrospective study, how was pain intensity measured in all patients? Do you have this
measurement in each patient's clinical history? Was the same scale used for all?
3. "median cost of the tumor group was more", What cost parameters were evaluated? hospital
stay? treatments? interventions? oncological surgery? only AP cost?
4. "The sensitivities of CT, US, MRCP, EUS and PET-CT were 97.7%(85/87), 84.1%(58/69),
95.7%(45/47), 100%(9/9) and 81.8%(9/11)". The sensitivity for the diagnosis of what? All
patients underwent to all diagnosis studies?  How did they find the sensitivity of diagnostic
studies?
5. There are studies said Acute Pancreatitis can be a early marker of pancreatic cancer, for this
reason, it is a disappointment not to have the stage of the tumors.
Please review this paper.
user
Title: Clinical Characteristic and Pathogenesis of Tumor-Induced Acute Pancreatitis: A
Predictive Model
Version: 1 Date: 26 Jul 2022
Reviewer's report:
The authors carry out a prospective study to determine the clinical characteristics and
pathogenesis of tumor-induced acute pancreatitis, and to develop a reliable prediction model of
the clinical features to guide the diagnosis and treatment.
Congratulations to the authors for having be able to carry out this study that shows significant
differences between groups (tumor vs non-tumor) and predictive factors which may lead to
improve the clinical suspicion of these patients. This is an interesting a well-written manuscript.
It has a few minor issues and some points of clarity from the authors would be helpful. Can you
explain these points better?
1. "360 admissions were random selected from those AP patients with other etiologies as the
non-tumor group".  I think that you have explained this part, because it will be  a cause of bias.
Explain the election criteria.
2. "aggravated intense pain in the upper abdomen was special symptoms of 88 patients". If
this is a retrospective study, how was pain intensity measured in all patients? Do you have this
measurement in each patient's clinical history? Was the same scale used for all?
3. "median cost of the tumor group was more", What cost parameters were evaluated? hospital
stay? treatments? interventions? oncological surgery? only AP cost?
4. "The sensitivities of CT, US, MRCP, EUS and PET-CT were 97.7%(85/87), 84.1%(58/69),
95.7%(45/47), 100%(9/9) and 81.8%(9/11)". The sensitivity for the diagnosis of what? All
patients underwent to all diagnosis studies?  How did they find the sensitivity of diagnostic
studies?
5. There are studies said Acute Pancreatitis can be a early marker of pancreatic cancer, for this
reason, it is a disappointment not to have the stage of the tumors.
assistant