Title: Characterization of Primary Small Intestinal Lymphoma: A Retrospective Study Based
on Double Balloon Endoscopy
Version: 2 Date: 14 Dec 2023
Reviewer:  Yuichiro Ikebuchi
Reviewer's report:
Although this is a report of a small number of cases from a single institution, we believe it is an
important contribution, given the scarcity of reports on small intestinal lymphoma.
Below are the issues I noticed:
1. In Table 3, what was the level of soluble IL-2 receptor in the laboratory examination?
2. What is the definition of "Aneurysmal dilation"? If possible, please add a typical image to
Figure 1.
3. Please define "deep ulcers," as in comment 2. If possible, add a typical image to Figure 2.
4. The sentence "Multivariate analysis showed that deep ulcers (p = 0.019, OR 0.028, 95% CI:
0.001-0.555) and aneurysmal dilation (p = 0.035, OR 0.057, 95% CI: 0.004-0.817) had statistical
significance for prognosis" would be more coherent if it were moved to the "Therapy and Clinical
Outcome" section."
Title: Characterization of Primary Small Intestinal Lymphoma: A Retrospective Study Based
on Double Balloon Endoscopy
Version: 2 Date: 14 Dec 2023
Reviewer:  Yuichiro Ikebuchi
Reviewer's report:
Although this is a report of a small number of cases from a single institution, we believe it is an
important contribution, given the scarcity of reports on small intestinal lymphoma.
Below are the issues I noticed:
1. In Table 3, what was the level of soluble IL-2 receptor in the laboratory examination?
2. What is the definition of "Aneurysmal dilation"? If possible, please add a typical image to
Figure 1.
3. Please define "deep ulcers," as in comment 2. If possible, add a typical image to Figure 2.
4. The sentence "Multivariate analysis showed that deep ulcers (p = 0.019, OR 0.028, 95% CI:
0.001-0.555) and aneurysmal dilation (p = 0.035, OR 0.057, 95% CI: 0.004-0.817) had statistical
significance for prognosis" would be more coherent if it were moved to the "Therapy and Clinical
Outcome" section."
Please review this paper.
user
Title: Characterization of Primary Small Intestinal Lymphoma: A Retrospective Study Based
on Double Balloon Endoscopy
Version: 2 Date: 14 Dec 2023
Reviewer:  Yuichiro Ikebuchi
Reviewer's report:
Although this is a report of a small number of cases from a single institution, we believe it is an
important contribution, given the scarcity of reports on small intestinal lymphoma.
Below are the issues I noticed:
1. In Table 3, what was the level of soluble IL-2 receptor in the laboratory examination?
2. What is the definition of "Aneurysmal dilation"? If possible, please add a typical image to
Figure 1.
3. Please define "deep ulcers," as in comment 2. If possible, add a typical image to Figure 2.
4. The sentence "Multivariate analysis showed that deep ulcers (p = 0.019, OR 0.028, 95% CI:
0.001-0.555) and aneurysmal dilation (p = 0.035, OR 0.057, 95% CI: 0.004-0.817) had statistical
significance for prognosis" would be more coherent if it were moved to the "Therapy and Clinical
Outcome" section."
assistant