Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 5 Date: 14 Feb 2021
Reviewer's report:
The study aimed to identify risk factors of NAFLD by genome wide CNV can can add significant
finding to the field. However, there are some fundamental issues that wasn't resolved through
the revision.
There wasn't any data from liver biopsies supporting the claim made by the genome wide
CNV analyses from peripheral blood. Such claims much be substantiated with data that directly
addresses the rationale of the study.  obtaining liver biopsies can be invasive but might be
essential in addressing the particular question that was being asked in this study.
A heat map was included in the revised manuscript. However, neither there were any explanation
( highlighted in red) in the discussion nor there were sufficient annotation. Thus even though
the heat map was included, it didn't add to the substance and understanding of the readers.
According to the manuscript figures, there were 63 losses and gains identified in the Y
chromosome. thus there was a huge impact from the sex chromosome which was excluded from
the study.
Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 5 Date: 14 Feb 2021
Reviewer's report:
The study aimed to identify risk factors of NAFLD by genome wide CNV can can add significant
finding to the field. However, there are some fundamental issues that wasn't resolved through
the revision.
There wasn't any data from liver biopsies supporting the claim made by the genome wide
CNV analyses from peripheral blood. Such claims much be substantiated with data that directly
addresses the rationale of the study.  obtaining liver biopsies can be invasive but might be
essential in addressing the particular question that was being asked in this study.
A heat map was included in the revised manuscript. However, neither there were any explanation
( highlighted in red) in the discussion nor there were sufficient annotation. Thus even though
the heat map was included, it didn't add to the substance and understanding of the readers.
According to the manuscript figures, there were 63 losses and gains identified in the Y
chromosome. thus there was a huge impact from the sex chromosome which was excluded from
the study.
Please review this paper.
user
Title: Identifying potential biomarkers of nonalcoholic fatty liver disease via genome-wide
analysis of copy number variation
Version: 5 Date: 14 Feb 2021
Reviewer's report:
The study aimed to identify risk factors of NAFLD by genome wide CNV can can add significant
finding to the field. However, there are some fundamental issues that wasn't resolved through
the revision.
There wasn't any data from liver biopsies supporting the claim made by the genome wide
CNV analyses from peripheral blood. Such claims much be substantiated with data that directly
addresses the rationale of the study.  obtaining liver biopsies can be invasive but might be
essential in addressing the particular question that was being asked in this study.
A heat map was included in the revised manuscript. However, neither there were any explanation
( highlighted in red) in the discussion nor there were sufficient annotation. Thus even though
the heat map was included, it didn't add to the substance and understanding of the readers.
According to the manuscript figures, there were 63 losses and gains identified in the Y
chromosome. thus there was a huge impact from the sex chromosome which was excluded from
the study.
assistant