Title: Sevoflurane inhibits cholangiocarcinoma via Wnt/#-catenin Signaling pathway
Version: 1 Date: 09 Apr 2023
Reviewer's report:
1. This is a good research paper that explores the mechanism of sevoflurane intervention in bile
duct epithelial cell carcinoma.
2. It is suggested that specific data of the findings should be appropriately added to the summary.
The data is more persuasive and allows readers to understand the paper more quickly.
3. The author chooses the Wnt/#-catenin signaling pathway as the research object. Please specify
the reasons for choosing this signaling pathway.
4. As a drug intervening in tumor through signal axis, it is suggested to supplement animal
experiments as much as possible in addition to cell tests. Studies conducted in vivo and in vitro
are more reliable.
5. The original image of WB strips studied was of high quality. Please provide the original cell
culture and flow cytometry images.
Title: Sevoflurane inhibits cholangiocarcinoma via Wnt/#-catenin Signaling pathway
Version: 1 Date: 09 Apr 2023
Reviewer's report:
1. This is a good research paper that explores the mechanism of sevoflurane intervention in bile
duct epithelial cell carcinoma.
2. It is suggested that specific data of the findings should be appropriately added to the summary.
The data is more persuasive and allows readers to understand the paper more quickly.
3. The author chooses the Wnt/#-catenin signaling pathway as the research object. Please specify
the reasons for choosing this signaling pathway.
4. As a drug intervening in tumor through signal axis, it is suggested to supplement animal
experiments as much as possible in addition to cell tests. Studies conducted in vivo and in vitro
are more reliable.
5. The original image of WB strips studied was of high quality. Please provide the original cell
culture and flow cytometry images.
Please review this paper.
user
Title: Sevoflurane inhibits cholangiocarcinoma via Wnt/#-catenin Signaling pathway
Version: 1 Date: 09 Apr 2023
Reviewer's report:
1. This is a good research paper that explores the mechanism of sevoflurane intervention in bile
duct epithelial cell carcinoma.
2. It is suggested that specific data of the findings should be appropriately added to the summary.
The data is more persuasive and allows readers to understand the paper more quickly.
3. The author chooses the Wnt/#-catenin signaling pathway as the research object. Please specify
the reasons for choosing this signaling pathway.
4. As a drug intervening in tumor through signal axis, it is suggested to supplement animal
experiments as much as possible in addition to cell tests. Studies conducted in vivo and in vitro
are more reliable.
5. The original image of WB strips studied was of high quality. Please provide the original cell
culture and flow cytometry images.
assistant