Title: Identification and immunological characterization of cuproptosis-related molecular
clusters in Ulcerative Colitis
Version: 2 Date: 11 Feb 2023
Reviewer:  Mehmet Ali Kosekli
Reviewer's report:
The paper titled 'Identification and immunological characterization of cuproptosis-related
molecular clusters in Ulcerative Colitis' is reviewed. Authors studied  immunological
characterization of cuproptosis-related molecular clusters in subjects with Ulcerative Colitis.
Comments:
a- Background data should be improved in introduction. Cuproptosis is associated with
inflammation (Front Immunol. 2022 Aug 4;13:930278. doi: 10.3389/fimmu.2022.930278).
On the other hand, gastrointestinal conditions (Iran J Colorectal Res 2022;10(3):2-13. DOI:
10.30476/ACRR.2022.97244.1160), and even functional bowel disorders (Fam Med Prim Care
Rev 2020; 22(2): 107–110. DOI: 10.5114/fmpcr.2020.95311) are characterized with some
degree of inflammatory burden.   Indeed, high degree of inflammatory molecules have been
reported in patients with UC (Wiener klinische Wochenschrift (2015)127:262-265.  DOI
10.1007/s00508-014-0683-5). Thus, studying immunological characterization of cuproptosis-
related molecular clusters in Ulcerative Colitis makes sense. Improve introduction accordingly
please.
b- Methods and results were presented well enough to conduct similar work and to understand
the study outcomes in an easy way.  Figure are informative.
c- Discussion needs to be improved. First, please state main outcomes at the beginning of
the discussion.   Second, please comment on clinical usage of the study results, and third,
conclusions should be a separate paragraph.
Overall, I recommend revision of the issues as mentioned above before reconsideration.
Title: Identification and immunological characterization of cuproptosis-related molecular
clusters in Ulcerative Colitis
Version: 2 Date: 11 Feb 2023
Reviewer:  Mehmet Ali Kosekli
Reviewer's report:
The paper titled 'Identification and immunological characterization of cuproptosis-related
molecular clusters in Ulcerative Colitis' is reviewed. Authors studied  immunological
characterization of cuproptosis-related molecular clusters in subjects with Ulcerative Colitis.
Comments:
a- Background data should be improved in introduction. Cuproptosis is associated with
inflammation (Front Immunol. 2022 Aug 4;13:930278. doi: 10.3389/fimmu.2022.930278).
On the other hand, gastrointestinal conditions (Iran J Colorectal Res 2022;10(3):2-13. DOI:
10.30476/ACRR.2022.97244.1160), and even functional bowel disorders (Fam Med Prim Care
Rev 2020; 22(2): 107–110. DOI: 10.5114/fmpcr.2020.95311) are characterized with some
degree of inflammatory burden.   Indeed, high degree of inflammatory molecules have been
reported in patients with UC (Wiener klinische Wochenschrift (2015)127:262-265.  DOI
10.1007/s00508-014-0683-5). Thus, studying immunological characterization of cuproptosis-
related molecular clusters in Ulcerative Colitis makes sense. Improve introduction accordingly
please.
b- Methods and results were presented well enough to conduct similar work and to understand
the study outcomes in an easy way.  Figure are informative.
c- Discussion needs to be improved. First, please state main outcomes at the beginning of
the discussion.   Second, please comment on clinical usage of the study results, and third,
conclusions should be a separate paragraph.
Overall, I recommend revision of the issues as mentioned above before reconsideration.
Please review this paper.
user
Title: Identification and immunological characterization of cuproptosis-related molecular
clusters in Ulcerative Colitis
Version: 2 Date: 11 Feb 2023
Reviewer:  Mehmet Ali Kosekli
Reviewer's report:
The paper titled 'Identification and immunological characterization of cuproptosis-related
molecular clusters in Ulcerative Colitis' is reviewed. Authors studied  immunological
characterization of cuproptosis-related molecular clusters in subjects with Ulcerative Colitis.
Comments:
a- Background data should be improved in introduction. Cuproptosis is associated with
inflammation (Front Immunol. 2022 Aug 4;13:930278. doi: 10.3389/fimmu.2022.930278).
On the other hand, gastrointestinal conditions (Iran J Colorectal Res 2022;10(3):2-13. DOI:
10.30476/ACRR.2022.97244.1160), and even functional bowel disorders (Fam Med Prim Care
Rev 2020; 22(2): 107–110. DOI: 10.5114/fmpcr.2020.95311) are characterized with some
degree of inflammatory burden.   Indeed, high degree of inflammatory molecules have been
reported in patients with UC (Wiener klinische Wochenschrift (2015)127:262-265.  DOI
10.1007/s00508-014-0683-5). Thus, studying immunological characterization of cuproptosis-
related molecular clusters in Ulcerative Colitis makes sense. Improve introduction accordingly
please.
b- Methods and results were presented well enough to conduct similar work and to understand
the study outcomes in an easy way.  Figure are informative.
c- Discussion needs to be improved. First, please state main outcomes at the beginning of
the discussion.   Second, please comment on clinical usage of the study results, and third,
conclusions should be a separate paragraph.
Overall, I recommend revision of the issues as mentioned above before reconsideration.
assistant