Reviewer's report
Title:Validation study of villous atrophy and small intestinal inflammation in
Swedish biopsy registers
Version: 2Date:9 October 2008
Reviewer: Vincenzo Villanacci
Reviewer's report:
The paper is well written and worthy of publication in particular compliments for
the extensions of the work and the data presented exaustive and complete.
I think that only minor revisions or suggestions are necessary.
I have no observations on the architecture of the paper the introduction, materials
and methods and results are perfect. I think that in the discussion is necessary to
spend some words about the definition of inflammation used in Sweden that
correspond to both Marsh 1 and Marsh 2 and Grade A of the new proposed
classification.
In this sense I think useful to cite also in the bibliography the paper of Brown and
coll : Brown I, Mino-Kenudson M, Deshpande V, Lauwers GY
intraepithelial lymphocytosis in architecturally preserved proximal small intestinal
mucosa: an increasing diagnostic problem with a wide differential diagnosis.Arch
Pathol Lab Med 2006 (130): 1020-5.It is important to remember that also in this
situation there is the possibility of coeliac disease with clinical symptoms and
laboratory and genetical test positive.
In table 1 it is important also to introduce the new proposed classification cited in
the discussion and relative bibliography :Corazza GR, Villanacci V
Coeliac Disease.Some considerations on the histological classification.
Journal of Clinical Pathol. 2005; 58, 573-574
No other observations
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interests' below.
Reviewer's report
Title:Validation study of villous atrophy and small intestinal inflammation in
Swedish biopsy registers
Version: 2Date:9 October 2008
Reviewer: Vincenzo Villanacci
Reviewer's report:
The paper is well written and worthy of publication in particular compliments for
the extensions of the work and the data presented exaustive and complete.
I think that only minor revisions or suggestions are necessary.
I have no observations on the architecture of the paper the introduction, materials
and methods and results are perfect. I think that in the discussion is necessary to
spend some words about the definition of inflammation used in Sweden that
correspond to both Marsh 1 and Marsh 2 and Grade A of the new proposed
classification.
In this sense I think useful to cite also in the bibliography the paper of Brown and
coll : Brown I, Mino-Kenudson M, Deshpande V, Lauwers GY
intraepithelial lymphocytosis in architecturally preserved proximal small intestinal
mucosa: an increasing diagnostic problem with a wide differential diagnosis.Arch
Pathol Lab Med 2006 (130): 1020-5.It is important to remember that also in this
situation there is the possibility of coeliac disease with clinical symptoms and
laboratory and genetical test positive.
In table 1 it is important also to introduce the new proposed classification cited in
the discussion and relative bibliography :Corazza GR, Villanacci V
Coeliac Disease.Some considerations on the histological classification.
Journal of Clinical Pathol. 2005; 58, 573-574
No other observations
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interests' below.
Please review this paper.
user
Reviewer's report
Title:Validation study of villous atrophy and small intestinal inflammation in
Swedish biopsy registers
Version: 2Date:9 October 2008
Reviewer: Vincenzo Villanacci
Reviewer's report:
The paper is well written and worthy of publication in particular compliments for
the extensions of the work and the data presented exaustive and complete.
I think that only minor revisions or suggestions are necessary.
I have no observations on the architecture of the paper the introduction, materials
and methods and results are perfect. I think that in the discussion is necessary to
spend some words about the definition of inflammation used in Sweden that
correspond to both Marsh 1 and Marsh 2 and Grade A of the new proposed
classification.
In this sense I think useful to cite also in the bibliography the paper of Brown and
coll : Brown I, Mino-Kenudson M, Deshpande V, Lauwers GY
intraepithelial lymphocytosis in architecturally preserved proximal small intestinal
mucosa: an increasing diagnostic problem with a wide differential diagnosis.Arch
Pathol Lab Med 2006 (130): 1020-5.It is important to remember that also in this
situation there is the possibility of coeliac disease with clinical symptoms and
laboratory and genetical test positive.
In table 1 it is important also to introduce the new proposed classification cited in
the discussion and relative bibliography :Corazza GR, Villanacci V
Coeliac Disease.Some considerations on the histological classification.
Journal of Clinical Pathol. 2005; 58, 573-574
No other observations
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: No, the manuscript does not need to be seen by a
statistician.
Declaration of competing interests:
I have no competing interests' below.
assistant