Title: Assessing Clinical Trial Failure Risk Factors And Reasons In Gastric Cancer
Version: 1 Date: 27 Jun 2022
Reviewer's report:
The authors discussed about the risk factors of clinical trial failure in gastric cancer. The cause
of clinical trial failure is critical issue for improving the strategies and cost-benefit of clinical
trial. But there are some unignorable problems in their study.
- In the previous study, the cancer type was not a predictive factor of clinical trials failing to
complete. Is it reasonable to discuss specific factors for gastric cancer now?
- The authors categorized the reasons behind the status for clinical trials of terminated status. But
I feel suspicious about the method of their categorization because there was minimal description
about their method. The authors should employ appropriate method to avoid arbitrary decision
of the reasons.
- The authors defined good and bad reasons according to the reasons they categorized. But some
of the studies terminated due to ethical reasons as well as trials no longer needed should be
defined as bad reasons because they do not contribute the improvement of clinical practice.
Furthermore, I question if it is realistic to make decision about the contribution of the studies
only according to the description of clinical trial registry.
Title: Assessing Clinical Trial Failure Risk Factors And Reasons In Gastric Cancer
Version: 1 Date: 27 Jun 2022
Reviewer's report:
The authors discussed about the risk factors of clinical trial failure in gastric cancer. The cause
of clinical trial failure is critical issue for improving the strategies and cost-benefit of clinical
trial. But there are some unignorable problems in their study.
- In the previous study, the cancer type was not a predictive factor of clinical trials failing to
complete. Is it reasonable to discuss specific factors for gastric cancer now?
- The authors categorized the reasons behind the status for clinical trials of terminated status. But
I feel suspicious about the method of their categorization because there was minimal description
about their method. The authors should employ appropriate method to avoid arbitrary decision
of the reasons.
- The authors defined good and bad reasons according to the reasons they categorized. But some
of the studies terminated due to ethical reasons as well as trials no longer needed should be
defined as bad reasons because they do not contribute the improvement of clinical practice.
Furthermore, I question if it is realistic to make decision about the contribution of the studies
only according to the description of clinical trial registry.
Please review this paper.
user
Title: Assessing Clinical Trial Failure Risk Factors And Reasons In Gastric Cancer
Version: 1 Date: 27 Jun 2022
Reviewer's report:
The authors discussed about the risk factors of clinical trial failure in gastric cancer. The cause
of clinical trial failure is critical issue for improving the strategies and cost-benefit of clinical
trial. But there are some unignorable problems in their study.
- In the previous study, the cancer type was not a predictive factor of clinical trials failing to
complete. Is it reasonable to discuss specific factors for gastric cancer now?
- The authors categorized the reasons behind the status for clinical trials of terminated status. But
I feel suspicious about the method of their categorization because there was minimal description
about their method. The authors should employ appropriate method to avoid arbitrary decision
of the reasons.
- The authors defined good and bad reasons according to the reasons they categorized. But some
of the studies terminated due to ethical reasons as well as trials no longer needed should be
defined as bad reasons because they do not contribute the improvement of clinical practice.
Furthermore, I question if it is realistic to make decision about the contribution of the studies
only according to the description of clinical trial registry.
assistant