Reviewer's report
Title:Preventive Effect of Irsogladine or Omeprazole on NSAIDs-Induced
Esophagitis, Peptic Ulcers, and Small Intestinal Lesions in Humans
Version: 1Date:20 January 2013
Reviewer: Ryuichi Iwakiri
Reviewer's report:
This study prospectively compared the effect of irsogladine and opeprazol on
NSAID induced gastrointestinal injury except colon. Authors indicated that both 2
drugs were effective to prevent esophagitis or peptic ulcers. On the other hand,
irsogladine alone had preventive effect on NSAI induced small intestinal injury.
1. Some time, it is difficult to detect small injury by capsule endoscopy. Statistical
differences were demonstrated by authors’ analyses. However, numbers of
lesions detected by capsule endoscope were few. It is questionable that the data
have actual significance. This is a short period study, therefore NSAID alone
control could be set. Such control might help to interpret authors’ data.
2. Authors adopted the data of fecal calprotectin and fecal occult blood to support
the data by capsule endoscope. However, measure unit of calprotectin
(micrograms of calprotectin per gram of stool) does not reflect absolute volume.
Adopted fecal occult blood test is qualitative examination and easily influenced
by food. Therefore, these 2 examination cannot enough support the data of
capsule endoscope.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Reviewer's report
Title:Preventive Effect of Irsogladine or Omeprazole on NSAIDs-Induced
Esophagitis, Peptic Ulcers, and Small Intestinal Lesions in Humans
Version: 1Date:20 January 2013
Reviewer: Ryuichi Iwakiri
Reviewer's report:
This study prospectively compared the effect of irsogladine and opeprazol on
NSAID induced gastrointestinal injury except colon. Authors indicated that both 2
drugs were effective to prevent esophagitis or peptic ulcers. On the other hand,
irsogladine alone had preventive effect on NSAI induced small intestinal injury.
1. Some time, it is difficult to detect small injury by capsule endoscopy. Statistical
differences were demonstrated by authors’ analyses. However, numbers of
lesions detected by capsule endoscope were few. It is questionable that the data
have actual significance. This is a short period study, therefore NSAID alone
control could be set. Such control might help to interpret authors’ data.
2. Authors adopted the data of fecal calprotectin and fecal occult blood to support
the data by capsule endoscope. However, measure unit of calprotectin
(micrograms of calprotectin per gram of stool) does not reflect absolute volume.
Adopted fecal occult blood test is qualitative examination and easily influenced
by food. Therefore, these 2 examination cannot enough support the data of
capsule endoscope.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
Please review this paper.
user
Reviewer's report
Title:Preventive Effect of Irsogladine or Omeprazole on NSAIDs-Induced
Esophagitis, Peptic Ulcers, and Small Intestinal Lesions in Humans
Version: 1Date:20 January 2013
Reviewer: Ryuichi Iwakiri
Reviewer's report:
This study prospectively compared the effect of irsogladine and opeprazol on
NSAID induced gastrointestinal injury except colon. Authors indicated that both 2
drugs were effective to prevent esophagitis or peptic ulcers. On the other hand,
irsogladine alone had preventive effect on NSAI induced small intestinal injury.
1. Some time, it is difficult to detect small injury by capsule endoscopy. Statistical
differences were demonstrated by authors’ analyses. However, numbers of
lesions detected by capsule endoscope were few. It is questionable that the data
have actual significance. This is a short period study, therefore NSAID alone
control could be set. Such control might help to interpret authors’ data.
2. Authors adopted the data of fecal calprotectin and fecal occult blood to support
the data by capsule endoscope. However, measure unit of calprotectin
(micrograms of calprotectin per gram of stool) does not reflect absolute volume.
Adopted fecal occult blood test is qualitative examination and easily influenced
by food. Therefore, these 2 examination cannot enough support the data of
capsule endoscope.
Level of interest: An article of importance in its field
Quality of written English: Needs some language corrections before being
published
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests.
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