Title: Association between the cardiometabolic index and non-alcoholic fatty liver disease:
insights from a general population
Version: 0 Date: 02 Nov 2021
Reviewer:  Hirokazu Takahashi
Reviewer's report:
The authors investigated the association between cardiometabolic index (CMI) and nonalcoholic
fatty liver disease (NAFLD) in the health checkups cohort.
Comments
1. Method. The reason why the authors excluded the subjects who had diabetes and/or impaired
fasting blood glucose is totally unclear. Please explain in detail.
2. Ethics. Page 4, line 17-20. Whereas the subjects were anonymized, and main study has been
approved by IRB, the authors should show the approved number of the study protocol for human
study. Please show the information about approved number of the protocol (main study) and
name of IRB.
3. Page 9, line 4. “These research data provide a new idea for the non-invasive evaluation of
NAFLD and are of great significance.” This is out of purpose of the current study. If so, The
authors should perform the ROC analysis and compare the established non-invasive evaluation
method like fatty liver index.
4. Table 2. Title. What does “AAPR” stand for?
5. Several brackets and unit (%) are missing in Table 1.
6. Page 4, line 2. Bracket for citation 22-25 is missing.
Title: Association between the cardiometabolic index and non-alcoholic fatty liver disease:
insights from a general population
Version: 0 Date: 02 Nov 2021
Reviewer:  Hirokazu Takahashi
Reviewer's report:
The authors investigated the association between cardiometabolic index (CMI) and nonalcoholic
fatty liver disease (NAFLD) in the health checkups cohort.
Comments
1. Method. The reason why the authors excluded the subjects who had diabetes and/or impaired
fasting blood glucose is totally unclear. Please explain in detail.
2. Ethics. Page 4, line 17-20. Whereas the subjects were anonymized, and main study has been
approved by IRB, the authors should show the approved number of the study protocol for human
study. Please show the information about approved number of the protocol (main study) and
name of IRB.
3. Page 9, line 4. “These research data provide a new idea for the non-invasive evaluation of
NAFLD and are of great significance.” This is out of purpose of the current study. If so, The
authors should perform the ROC analysis and compare the established non-invasive evaluation
method like fatty liver index.
4. Table 2. Title. What does “AAPR” stand for?
5. Several brackets and unit (%) are missing in Table 1.
6. Page 4, line 2. Bracket for citation 22-25 is missing.
Please review this paper.
user
Title: Association between the cardiometabolic index and non-alcoholic fatty liver disease:
insights from a general population
Version: 0 Date: 02 Nov 2021
Reviewer:  Hirokazu Takahashi
Reviewer's report:
The authors investigated the association between cardiometabolic index (CMI) and nonalcoholic
fatty liver disease (NAFLD) in the health checkups cohort.
Comments
1. Method. The reason why the authors excluded the subjects who had diabetes and/or impaired
fasting blood glucose is totally unclear. Please explain in detail.
2. Ethics. Page 4, line 17-20. Whereas the subjects were anonymized, and main study has been
approved by IRB, the authors should show the approved number of the study protocol for human
study. Please show the information about approved number of the protocol (main study) and
name of IRB.
3. Page 9, line 4. “These research data provide a new idea for the non-invasive evaluation of
NAFLD and are of great significance.” This is out of purpose of the current study. If so, The
authors should perform the ROC analysis and compare the established non-invasive evaluation
method like fatty liver index.
4. Table 2. Title. What does “AAPR” stand for?
5. Several brackets and unit (%) are missing in Table 1.
6. Page 4, line 2. Bracket for citation 22-25 is missing.
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