Title: Phosphoserine Phosphatase as a prognostic biomarker in patients with gastric cancer and
its potential association with immune cells
Version: 0 Date: 22 Sep 2021
Reviewer's report:
This is an interesting study based on a sufficient sample size, but there are some concerns that
should be addressed.
1. In the chapter "High PSPH level indicates poor prognosis in gastric cancer", the authors refer
to Table 3 and describe PSPH expression as a risk factor.
This is considered to be an exaggeration. The fact is that it was significant in univariate analysis,
but no longer so in multivariate analysis.
It is possible that High PSPH is a risk factor, but it cannot be stated definitively, and the wording
should be revised.
2. In the statistical analysis, it is stated that the Wilcoxon signed rank test was used, but the
comparison of PSPH high vs PSPH low should be unpaired. This is an inappropriate method.
3. In Table 3, the cutoff for age is 59 years. This is a strange value, but why was it set at this
value? There is no explanation in the paper, so please add an explanation.
Title: Phosphoserine Phosphatase as a prognostic biomarker in patients with gastric cancer and
its potential association with immune cells
Version: 0 Date: 22 Sep 2021
Reviewer's report:
This is an interesting study based on a sufficient sample size, but there are some concerns that
should be addressed.
1. In the chapter "High PSPH level indicates poor prognosis in gastric cancer", the authors refer
to Table 3 and describe PSPH expression as a risk factor.
This is considered to be an exaggeration. The fact is that it was significant in univariate analysis,
but no longer so in multivariate analysis.
It is possible that High PSPH is a risk factor, but it cannot be stated definitively, and the wording
should be revised.
2. In the statistical analysis, it is stated that the Wilcoxon signed rank test was used, but the
comparison of PSPH high vs PSPH low should be unpaired. This is an inappropriate method.
3. In Table 3, the cutoff for age is 59 years. This is a strange value, but why was it set at this
value? There is no explanation in the paper, so please add an explanation.
Please review this paper.
user
Title: Phosphoserine Phosphatase as a prognostic biomarker in patients with gastric cancer and
its potential association with immune cells
Version: 0 Date: 22 Sep 2021
Reviewer's report:
This is an interesting study based on a sufficient sample size, but there are some concerns that
should be addressed.
1. In the chapter "High PSPH level indicates poor prognosis in gastric cancer", the authors refer
to Table 3 and describe PSPH expression as a risk factor.
This is considered to be an exaggeration. The fact is that it was significant in univariate analysis,
but no longer so in multivariate analysis.
It is possible that High PSPH is a risk factor, but it cannot be stated definitively, and the wording
should be revised.
2. In the statistical analysis, it is stated that the Wilcoxon signed rank test was used, but the
comparison of PSPH high vs PSPH low should be unpaired. This is an inappropriate method.
3. In Table 3, the cutoff for age is 59 years. This is a strange value, but why was it set at this
value? There is no explanation in the paper, so please add an explanation.
assistant