Title: Stereotactic body radiation therapy as an effective local treatment for advanced
hepatocellular carcinoma patients with inferior vena cava and right atrial tumor thrombus
Version: 1 Date: 05 Sep 2022
Reviewer's report:
Major and minor comments
1. There are a small number of patients (15).
2. Clarify how grade ¾ or 5 adverse events were attributed to SBRT or not. Presumably many
patients died at some time. How was it determined if events were attributed to treatment?
3. State what the mean dose to the liver was for all patients, and those with liver failure.
4. Specifically comment on any (or lack there of) cardiac complications/ malignant PE, etc.
5. Clarify how these patients were selected, and what the denominator of patients treated with
radiation therapy was during the same time period. How were patients with portal vein and IVC
invasion handled?
6. Clarify how many patients had invasion to the heart versus not, and what the doses to the
heart were.
7. Why were the arms down for radiation therapy? Was any entry dose considered?
8. There appear to be repeat figures, or similar figures. I recommend one figure be more clearly
labelled, with fewer screen shots to demonstrate the imaging, radiation plan and response more
simply.
9. Add page numbers and correct typographical errors (e.g. ‘cana’ to ‘cava’ in discussion.)
Title: Stereotactic body radiation therapy as an effective local treatment for advanced
hepatocellular carcinoma patients with inferior vena cava and right atrial tumor thrombus
Version: 1 Date: 05 Sep 2022
Reviewer's report:
Major and minor comments
1. There are a small number of patients (15).
2. Clarify how grade ¾ or 5 adverse events were attributed to SBRT or not. Presumably many
patients died at some time. How was it determined if events were attributed to treatment?
3. State what the mean dose to the liver was for all patients, and those with liver failure.
4. Specifically comment on any (or lack there of) cardiac complications/ malignant PE, etc.
5. Clarify how these patients were selected, and what the denominator of patients treated with
radiation therapy was during the same time period. How were patients with portal vein and IVC
invasion handled?
6. Clarify how many patients had invasion to the heart versus not, and what the doses to the
heart were.
7. Why were the arms down for radiation therapy? Was any entry dose considered?
8. There appear to be repeat figures, or similar figures. I recommend one figure be more clearly
labelled, with fewer screen shots to demonstrate the imaging, radiation plan and response more
simply.
9. Add page numbers and correct typographical errors (e.g. ‘cana’ to ‘cava’ in discussion.)
Please review this paper.
user
Title: Stereotactic body radiation therapy as an effective local treatment for advanced
hepatocellular carcinoma patients with inferior vena cava and right atrial tumor thrombus
Version: 1 Date: 05 Sep 2022
Reviewer's report:
Major and minor comments
1. There are a small number of patients (15).
2. Clarify how grade ¾ or 5 adverse events were attributed to SBRT or not. Presumably many
patients died at some time. How was it determined if events were attributed to treatment?
3. State what the mean dose to the liver was for all patients, and those with liver failure.
4. Specifically comment on any (or lack there of) cardiac complications/ malignant PE, etc.
5. Clarify how these patients were selected, and what the denominator of patients treated with
radiation therapy was during the same time period. How were patients with portal vein and IVC
invasion handled?
6. Clarify how many patients had invasion to the heart versus not, and what the doses to the
heart were.
7. Why were the arms down for radiation therapy? Was any entry dose considered?
8. There appear to be repeat figures, or similar figures. I recommend one figure be more clearly
labelled, with fewer screen shots to demonstrate the imaging, radiation plan and response more
simply.
9. Add page numbers and correct typographical errors (e.g. ‘cana’ to ‘cava’ in discussion.)
assistant