Title: Clinicopathological and prognostic evaluations of anorectal cancer after fecal diversion
for patients with Crohn's disease
Version: 2 Date: 05 Mar 2021
Reviewer:  Weiming Zhu
Reviewer's report:
the topic of this paper is interesting, the authors reviewed the 1615 CD patients and found 232
patients with diverted stomas, among which 10 patients suffered from anorectal cancers and
received APR. and the authors emphasis the importance of surveillance in CD patients after
diversion.
The following points should be clarified:
1 In the “Methods” of the abstract, the authors stated that “Patients diagnosed with anorectal
cancer following fecal diversion were identified”, but in the text, there were also 31 anorectal
cancer patients in the non-diverted group were matched , and in the diverted group, the number
of patients were 12 in the “Results” paragraph but 11 in the text. I’m not certain if the 31 patients
were CD patients in the 1615 patients group, or from other groups.
2 The paper described the result of the 10 patients undergoing abdominoperineal resection, but
the rest one among the 11 patients were not given.
3 The authors classified the location of cancer as anorectal and perianal fistula, but from the
histopathology, the perianal fistula originated cancer are also adenocarcimoma. Is it meaningful
to classify the cancer simply by location?
4 “heavy iron therapy”in Table 2 need simple description. Tumor site percentage are not shown
in Table 3.
Title: Clinicopathological and prognostic evaluations of anorectal cancer after fecal diversion
for patients with Crohn's disease
Version: 2 Date: 05 Mar 2021
Reviewer:  Weiming Zhu
Reviewer's report:
the topic of this paper is interesting, the authors reviewed the 1615 CD patients and found 232
patients with diverted stomas, among which 10 patients suffered from anorectal cancers and
received APR. and the authors emphasis the importance of surveillance in CD patients after
diversion.
The following points should be clarified:
1 In the “Methods” of the abstract, the authors stated that “Patients diagnosed with anorectal
cancer following fecal diversion were identified”, but in the text, there were also 31 anorectal
cancer patients in the non-diverted group were matched , and in the diverted group, the number
of patients were 12 in the “Results” paragraph but 11 in the text. I’m not certain if the 31 patients
were CD patients in the 1615 patients group, or from other groups.
2 The paper described the result of the 10 patients undergoing abdominoperineal resection, but
the rest one among the 11 patients were not given.
3 The authors classified the location of cancer as anorectal and perianal fistula, but from the
histopathology, the perianal fistula originated cancer are also adenocarcimoma. Is it meaningful
to classify the cancer simply by location?
4 “heavy iron therapy”in Table 2 need simple description. Tumor site percentage are not shown
in Table 3.
Please review this paper.
user
Title: Clinicopathological and prognostic evaluations of anorectal cancer after fecal diversion
for patients with Crohn's disease
Version: 2 Date: 05 Mar 2021
Reviewer:  Weiming Zhu
Reviewer's report:
the topic of this paper is interesting, the authors reviewed the 1615 CD patients and found 232
patients with diverted stomas, among which 10 patients suffered from anorectal cancers and
received APR. and the authors emphasis the importance of surveillance in CD patients after
diversion.
The following points should be clarified:
1 In the “Methods” of the abstract, the authors stated that “Patients diagnosed with anorectal
cancer following fecal diversion were identified”, but in the text, there were also 31 anorectal
cancer patients in the non-diverted group were matched , and in the diverted group, the number
of patients were 12 in the “Results” paragraph but 11 in the text. I’m not certain if the 31 patients
were CD patients in the 1615 patients group, or from other groups.
2 The paper described the result of the 10 patients undergoing abdominoperineal resection, but
the rest one among the 11 patients were not given.
3 The authors classified the location of cancer as anorectal and perianal fistula, but from the
histopathology, the perianal fistula originated cancer are also adenocarcimoma. Is it meaningful
to classify the cancer simply by location?
4 “heavy iron therapy”in Table 2 need simple description. Tumor site percentage are not shown
in Table 3.
assistant