Reviewer's report
Title:Decreased PCSK9 expression in human Hepatocellular Carcinoma
Version:3Date:30 March 2015
Reviewer: Bertrand Cariou
Reviewer's report:
The revised version has been improved by adding the expression data of LDL-R
that correlates with those of PCSK9. However, some questions remain, to my
opinion, unanswered. This is notably the case concerning the relationship
between HCC, fibrosis and plasma PCSK9 concentrations.
Additional comments:
- to validate the hypothesis that PCSK9 in HCC downregulates LDL-R expression
at a post-transcriptional level, LDL-R mRNA should be measured in HCC.
- abstract (conclusions): conversely increased LDL-R expression rather than
decreased...
- the discussion is too long.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Reviewer's report
Title:Decreased PCSK9 expression in human Hepatocellular Carcinoma
Version:3Date:30 March 2015
Reviewer: Bertrand Cariou
Reviewer's report:
The revised version has been improved by adding the expression data of LDL-R
that correlates with those of PCSK9. However, some questions remain, to my
opinion, unanswered. This is notably the case concerning the relationship
between HCC, fibrosis and plasma PCSK9 concentrations.
Additional comments:
- to validate the hypothesis that PCSK9 in HCC downregulates LDL-R expression
at a post-transcriptional level, LDL-R mRNA should be measured in HCC.
- abstract (conclusions): conversely increased LDL-R expression rather than
decreased...
- the discussion is too long.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
Please review this paper.
user
Reviewer's report
Title:Decreased PCSK9 expression in human Hepatocellular Carcinoma
Version:3Date:30 March 2015
Reviewer: Bertrand Cariou
Reviewer's report:
The revised version has been improved by adding the expression data of LDL-R
that correlates with those of PCSK9. However, some questions remain, to my
opinion, unanswered. This is notably the case concerning the relationship
between HCC, fibrosis and plasma PCSK9 concentrations.
Additional comments:
- to validate the hypothesis that PCSK9 in HCC downregulates LDL-R expression
at a post-transcriptional level, LDL-R mRNA should be measured in HCC.
- abstract (conclusions): conversely increased LDL-R expression rather than
decreased...
- the discussion is too long.
Level of interest: An article whose findings are important to those with closely
related research interests
Quality of written English: Acceptable
Statistical review: Yes, but I do not feel adequately qualified to assess the
statistics.
Declaration of competing interests:
I declare that I have no competing interests
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