Title: Association of Biological Aging and the Prevalence of Nonalcoholic Fatty Liver Disease:
a Population-based Study
Version: 1 Date: 30 Mar 2025
Reviewer's report:
Liu et al. found an independent association between the aging biomarkers with NAFLD in the
NHANES database. This study is clear and technically sounds. However, the association of
aging with NAFLD is already known, but yet not comprehensively understood finding. I only
have a few concerns:
1. Current understanding on aging and NAFLD needs to be introduced. For example, the
prevalence of NAFLD was 44.2% (269441/608994) for older adults in South Korea (Clin
Mol Hepatol. 2022;28(3):510-521). The prevalence of NAFLD in all age groups (20-39 young
adults, 40 or above, >=65 older adults) need to be introduced to better deliver currently known
knowledge.
2. 2.4 Calculation of Biological Aging is too simple. Can you provide a brief description on how
did you evaluate the biomarkers?
3. There is no direct discussion why aging may lead to the liver fat accumulation. It may be due
to accumulation of fat within the liver or weakened ability to clear fat contents within the liver.
Title: Association of Biological Aging and the Prevalence of Nonalcoholic Fatty Liver Disease:
a Population-based Study
Version: 1 Date: 30 Mar 2025
Reviewer's report:
Liu et al. found an independent association between the aging biomarkers with NAFLD in the
NHANES database. This study is clear and technically sounds. However, the association of
aging with NAFLD is already known, but yet not comprehensively understood finding. I only
have a few concerns:
1. Current understanding on aging and NAFLD needs to be introduced. For example, the
prevalence of NAFLD was 44.2% (269441/608994) for older adults in South Korea (Clin
Mol Hepatol. 2022;28(3):510-521). The prevalence of NAFLD in all age groups (20-39 young
adults, 40 or above, >=65 older adults) need to be introduced to better deliver currently known
knowledge.
2. 2.4 Calculation of Biological Aging is too simple. Can you provide a brief description on how
did you evaluate the biomarkers?
3. There is no direct discussion why aging may lead to the liver fat accumulation. It may be due
to accumulation of fat within the liver or weakened ability to clear fat contents within the liver.
Please review this paper.
user
Title: Association of Biological Aging and the Prevalence of Nonalcoholic Fatty Liver Disease:
a Population-based Study
Version: 1 Date: 30 Mar 2025
Reviewer's report:
Liu et al. found an independent association between the aging biomarkers with NAFLD in the
NHANES database. This study is clear and technically sounds. However, the association of
aging with NAFLD is already known, but yet not comprehensively understood finding. I only
have a few concerns:
1. Current understanding on aging and NAFLD needs to be introduced. For example, the
prevalence of NAFLD was 44.2% (269441/608994) for older adults in South Korea (Clin
Mol Hepatol. 2022;28(3):510-521). The prevalence of NAFLD in all age groups (20-39 young
adults, 40 or above, >=65 older adults) need to be introduced to better deliver currently known
knowledge.
2. 2.4 Calculation of Biological Aging is too simple. Can you provide a brief description on how
did you evaluate the biomarkers?
3. There is no direct discussion why aging may lead to the liver fat accumulation. It may be due
to accumulation of fat within the liver or weakened ability to clear fat contents within the liver.
assistant