Title: Combined application of chondroitinase ABC and photobiomodulation with low-intensity
laser on the anal sphincter repair in rabbit
Version: 1 Date: 27 Oct 2021
Reviewer:  Hélio Plapler
Reviewer's report:
Congratulations for your research, This is a very important and well developed study regarding
the use of LLL in sphincter injuries. Although I have no remarks about the method, I found the
results' explanation a little confuse (please, see below). With a little corrections I believe it will
be ready to be published.
line 39: (except the control group) (p < 0.0001). Maximum squeeze pressure in all study groups
was...
line 49: Key words: Chondroitinase ABC (there is no such term in the MeSH)
line 97: According ... (EAS, IAS... ) please describe the initials as written for the first time.
lines 103-7: You should describe all parameters (spot size, power density, total energy, etc).
lines 181-2: but could not reach the level of the intact animals (p<0.0001 ). according to what
you stablished in the "statistical methods" these values are not significant (p> 0,05). I understand
what you intent to say but think about rephrasing these paragraphs. You mean that there is
statistical difference between the control and the studied groups, but due to what is written in
the methods section (see comment above) it seems confuse to the readers. There are other lines
with the same textual construction that require your attention.
Title: Combined application of chondroitinase ABC and photobiomodulation with low-intensity
laser on the anal sphincter repair in rabbit
Version: 1 Date: 27 Oct 2021
Reviewer:  Hélio Plapler
Reviewer's report:
Congratulations for your research, This is a very important and well developed study regarding
the use of LLL in sphincter injuries. Although I have no remarks about the method, I found the
results' explanation a little confuse (please, see below). With a little corrections I believe it will
be ready to be published.
line 39: (except the control group) (p < 0.0001). Maximum squeeze pressure in all study groups
was...
line 49: Key words: Chondroitinase ABC (there is no such term in the MeSH)
line 97: According ... (EAS, IAS... ) please describe the initials as written for the first time.
lines 103-7: You should describe all parameters (spot size, power density, total energy, etc).
lines 181-2: but could not reach the level of the intact animals (p<0.0001 ). according to what
you stablished in the "statistical methods" these values are not significant (p> 0,05). I understand
what you intent to say but think about rephrasing these paragraphs. You mean that there is
statistical difference between the control and the studied groups, but due to what is written in
the methods section (see comment above) it seems confuse to the readers. There are other lines
with the same textual construction that require your attention.
Please review this paper.
user
Title: Combined application of chondroitinase ABC and photobiomodulation with low-intensity
laser on the anal sphincter repair in rabbit
Version: 1 Date: 27 Oct 2021
Reviewer:  Hélio Plapler
Reviewer's report:
Congratulations for your research, This is a very important and well developed study regarding
the use of LLL in sphincter injuries. Although I have no remarks about the method, I found the
results' explanation a little confuse (please, see below). With a little corrections I believe it will
be ready to be published.
line 39: (except the control group) (p < 0.0001). Maximum squeeze pressure in all study groups
was...
line 49: Key words: Chondroitinase ABC (there is no such term in the MeSH)
line 97: According ... (EAS, IAS... ) please describe the initials as written for the first time.
lines 103-7: You should describe all parameters (spot size, power density, total energy, etc).
lines 181-2: but could not reach the level of the intact animals (p<0.0001 ). according to what
you stablished in the "statistical methods" these values are not significant (p> 0,05). I understand
what you intent to say but think about rephrasing these paragraphs. You mean that there is
statistical difference between the control and the studied groups, but due to what is written in
the methods section (see comment above) it seems confuse to the readers. There are other lines
with the same textual construction that require your attention.
assistant