Title: The liver steatosis severity and lipid characteristics in primary biliary cholangitis
Version: 0 Date: 08 Jul 2021
Reviewer:  Vik Meadows
Reviewer's report:
The authors present an interesting study on the lipid levels in various chronic liver diseases in
comparison to PBC patients. They found increased HDL and decreased CAP in PBC patients
which may be indicative of reduced PBC comorbidity of atherosclerosis.
There are some points the authors must address prior to revision for publication:
1. the authors should clarify the rationale for including excessive drinking in the control group
cohort. Alcohol consumption increases hepatic steatosis and may be why PBC patients had
higher HDL compared to healthy control.
2. correlation analysis should be performed to further understand the role of HDL and PBC-
atherosclerosis progression. Did any PBC patients develop atherosclerosis? If so, what were
their HDL levels? Explorations of this nature will improve the manuscript and increase clinical
impact.
3. The authors mention H&E, CK-19, and other stains performed on biopsies of patients. These
were not found in this manuscript. Results of these stains should be detailed in paper or these
methods should be removed from the manuscript.
Title: The liver steatosis severity and lipid characteristics in primary biliary cholangitis
Version: 0 Date: 08 Jul 2021
Reviewer:  Vik Meadows
Reviewer's report:
The authors present an interesting study on the lipid levels in various chronic liver diseases in
comparison to PBC patients. They found increased HDL and decreased CAP in PBC patients
which may be indicative of reduced PBC comorbidity of atherosclerosis.
There are some points the authors must address prior to revision for publication:
1. the authors should clarify the rationale for including excessive drinking in the control group
cohort. Alcohol consumption increases hepatic steatosis and may be why PBC patients had
higher HDL compared to healthy control.
2. correlation analysis should be performed to further understand the role of HDL and PBC-
atherosclerosis progression. Did any PBC patients develop atherosclerosis? If so, what were
their HDL levels? Explorations of this nature will improve the manuscript and increase clinical
impact.
3. The authors mention H&E, CK-19, and other stains performed on biopsies of patients. These
were not found in this manuscript. Results of these stains should be detailed in paper or these
methods should be removed from the manuscript.
Please review this paper.
user
Title: The liver steatosis severity and lipid characteristics in primary biliary cholangitis
Version: 0 Date: 08 Jul 2021
Reviewer:  Vik Meadows
Reviewer's report:
The authors present an interesting study on the lipid levels in various chronic liver diseases in
comparison to PBC patients. They found increased HDL and decreased CAP in PBC patients
which may be indicative of reduced PBC comorbidity of atherosclerosis.
There are some points the authors must address prior to revision for publication:
1. the authors should clarify the rationale for including excessive drinking in the control group
cohort. Alcohol consumption increases hepatic steatosis and may be why PBC patients had
higher HDL compared to healthy control.
2. correlation analysis should be performed to further understand the role of HDL and PBC-
atherosclerosis progression. Did any PBC patients develop atherosclerosis? If so, what were
their HDL levels? Explorations of this nature will improve the manuscript and increase clinical
impact.
3. The authors mention H&E, CK-19, and other stains performed on biopsies of patients. These
were not found in this manuscript. Results of these stains should be detailed in paper or these
methods should be removed from the manuscript.
assistant