Title: ICG-r15 Predicts Esophageal Varices in Compensated Liver Cirrhosis: A Noninvasive
Approach
Version: 0 Date: 11 Mar 2024
Reviewer's report:
This is a nice retrospective work by Xu Han and colleagues, which evaluates non-invasive
methods to detect high-risk esophageal varices in patients with compensated cirrhosis. Among
the methods evaluated, ICG-r15 appears to determine with good accuracy the presence of high-
risk esophageal varices in patients with compensated liver cirrhosis.
The results of the study show that measuring ICG-r15 can be a simple and quick tool for
evaluating portal hypertension in patients with liver cirrhosis.
However, I have some considerations:
I would like to know if the ICG measurement is performed routinely in all patients who undergo
upper digestive endoscopy, if so, this information should be written in the manuscript;
The ICG-r15 measurement was performed on the same day as the upper digestive endoscopy;
It is described that the sensitivity is 0.849 and the specificity is 0.662, but, in table 3, it is written
that the sensitivity is 0.662 and the specificity is 0.849 for ICG-r15. Please review the correct
information;
Still in table 3, the specificity and sensitivity are not in percentages as reported;
Over the 3-year period, how many patients were evaluated for the study and how many were
excluded.
Title: ICG-r15 Predicts Esophageal Varices in Compensated Liver Cirrhosis: A Noninvasive
Approach
Version: 0 Date: 11 Mar 2024
Reviewer's report:
This is a nice retrospective work by Xu Han and colleagues, which evaluates non-invasive
methods to detect high-risk esophageal varices in patients with compensated cirrhosis. Among
the methods evaluated, ICG-r15 appears to determine with good accuracy the presence of high-
risk esophageal varices in patients with compensated liver cirrhosis.
The results of the study show that measuring ICG-r15 can be a simple and quick tool for
evaluating portal hypertension in patients with liver cirrhosis.
However, I have some considerations:
I would like to know if the ICG measurement is performed routinely in all patients who undergo
upper digestive endoscopy, if so, this information should be written in the manuscript;
The ICG-r15 measurement was performed on the same day as the upper digestive endoscopy;
It is described that the sensitivity is 0.849 and the specificity is 0.662, but, in table 3, it is written
that the sensitivity is 0.662 and the specificity is 0.849 for ICG-r15. Please review the correct
information;
Still in table 3, the specificity and sensitivity are not in percentages as reported;
Over the 3-year period, how many patients were evaluated for the study and how many were
excluded.
Please review this paper.
user
Title: ICG-r15 Predicts Esophageal Varices in Compensated Liver Cirrhosis: A Noninvasive
Approach
Version: 0 Date: 11 Mar 2024
Reviewer's report:
This is a nice retrospective work by Xu Han and colleagues, which evaluates non-invasive
methods to detect high-risk esophageal varices in patients with compensated cirrhosis. Among
the methods evaluated, ICG-r15 appears to determine with good accuracy the presence of high-
risk esophageal varices in patients with compensated liver cirrhosis.
The results of the study show that measuring ICG-r15 can be a simple and quick tool for
evaluating portal hypertension in patients with liver cirrhosis.
However, I have some considerations:
I would like to know if the ICG measurement is performed routinely in all patients who undergo
upper digestive endoscopy, if so, this information should be written in the manuscript;
The ICG-r15 measurement was performed on the same day as the upper digestive endoscopy;
It is described that the sensitivity is 0.849 and the specificity is 0.662, but, in table 3, it is written
that the sensitivity is 0.662 and the specificity is 0.849 for ICG-r15. Please review the correct
information;
Still in table 3, the specificity and sensitivity are not in percentages as reported;
Over the 3-year period, how many patients were evaluated for the study and how many were
excluded.
assistant