Reviewer's report
Title:Overexpression of SLC38A1 is associated with poorer prognosis in Chinese
patients with gastric cancer
Version:2Date:3 November 2013
Reviewer: Sumiya Ishigami
Reviewer's report:
What is the positive control of SLC38A1? Did author always evaluate expression
of SLC38A1 under the positive and negative control? Please add in the method
section.
What was the “ thrombosis” in the tables? Is it necessary to analyze as
prognostic marker?
Previous reports suggested that PCNA and p53 were independent prognostic
markers. Why did not authors insert these factors in multivariate analysis?
Why did the authors evaluate “anemia” in the multivariate analysis?
Clinical factors which are significant for survival by univariate analysis should be
included in multivariate analysis. Please delete.
Please state why histology is selected as independent prognostic marker.
B SE Wald df Sig. Exp(B) 95.0% CI Exp(B) in table 2 is too hard to understand.
There is no discussion about significant correlation between SLC38A1 and
clinical factors (histology and PCNA).
“Survival and prognostic factors” in the discussion section.
Survival significance of SLC38A1 is very poorly described Please enrich this part.
“Molecular markers for the development and progression of gastric cancer
include p53[33], nm23 [34], CD44 [35],and p-mTOR [13]. “ is not necessary.
Please delete.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Reviewer's report
Title:Overexpression of SLC38A1 is associated with poorer prognosis in Chinese
patients with gastric cancer
Version:2Date:3 November 2013
Reviewer: Sumiya Ishigami
Reviewer's report:
What is the positive control of SLC38A1? Did author always evaluate expression
of SLC38A1 under the positive and negative control? Please add in the method
section.
What was the “ thrombosis” in the tables? Is it necessary to analyze as
prognostic marker?
Previous reports suggested that PCNA and p53 were independent prognostic
markers. Why did not authors insert these factors in multivariate analysis?
Why did the authors evaluate “anemia” in the multivariate analysis?
Clinical factors which are significant for survival by univariate analysis should be
included in multivariate analysis. Please delete.
Please state why histology is selected as independent prognostic marker.
B SE Wald df Sig. Exp(B) 95.0% CI Exp(B) in table 2 is too hard to understand.
There is no discussion about significant correlation between SLC38A1 and
clinical factors (histology and PCNA).
“Survival and prognostic factors” in the discussion section.
Survival significance of SLC38A1 is very poorly described Please enrich this part.
“Molecular markers for the development and progression of gastric cancer
include p53[33], nm23 [34], CD44 [35],and p-mTOR [13]. “ is not necessary.
Please delete.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
Please review this paper.
user
Reviewer's report
Title:Overexpression of SLC38A1 is associated with poorer prognosis in Chinese
patients with gastric cancer
Version:2Date:3 November 2013
Reviewer: Sumiya Ishigami
Reviewer's report:
What is the positive control of SLC38A1? Did author always evaluate expression
of SLC38A1 under the positive and negative control? Please add in the method
section.
What was the “ thrombosis” in the tables? Is it necessary to analyze as
prognostic marker?
Previous reports suggested that PCNA and p53 were independent prognostic
markers. Why did not authors insert these factors in multivariate analysis?
Why did the authors evaluate “anemia” in the multivariate analysis?
Clinical factors which are significant for survival by univariate analysis should be
included in multivariate analysis. Please delete.
Please state why histology is selected as independent prognostic marker.
B SE Wald df Sig. Exp(B) 95.0% CI Exp(B) in table 2 is too hard to understand.
There is no discussion about significant correlation between SLC38A1 and
clinical factors (histology and PCNA).
“Survival and prognostic factors” in the discussion section.
Survival significance of SLC38A1 is very poorly described Please enrich this part.
“Molecular markers for the development and progression of gastric cancer
include p53[33], nm23 [34], CD44 [35],and p-mTOR [13]. “ is not necessary.
Please delete.
Level of interest: An article of importance in its field
Quality of written English: Acceptable
Statistical review: Yes, and I have assessed the statistics in my report.
assistant