Title: Triglyceride glucose waist circumference and Non alcoholic fatty liver disease: a
systematic review and meta analysis
Version: 1 Date: 30 Mar 2025
Reviewer's report:
Dear Authors,
Thank you for resubmitting your manuscript  for further review. I appreciate the revisions made
and the detailed responses to my previous comments. Below is my assessment of the revised
manuscript:
Updated Prevalence and Burden of NAFLD
I acknowledge that the prevalence of NAFLD has been updated in the Introduction section. The
manuscript now offers a more comprehensive and updated context.
Thank you for linking the TyG-WC index to insulin resistance  and explaining its connection
to the development of NAFLD in the Discussion. However, to make these relationships clearer,
I suggest incorporating a visual illustration that maps out the pathways from TyG index to IR,
and then from IR to the progression of NAFLD. Many studies have explored these pathways
and you can use them.
Also you can mention the role of obesity, particularly waist circumference, in this process. WC
is a key indicator of visceral fat and has a well-established link to IR and NAFLD progression
and you can add this information in your illustration.
Figure 5 Labels
Thank you for updating Figure 5. However, I was unable to open the new file. Please resend
it for review.
Overall, the revisions have improved the clarity and quality of the manuscript. However, I
suggest the addition of a visual mechanism illustration, as discussed above, to further strengthen
the paper.
Title: Triglyceride glucose waist circumference and Non alcoholic fatty liver disease: a
systematic review and meta analysis
Version: 1 Date: 30 Mar 2025
Reviewer's report:
Dear Authors,
Thank you for resubmitting your manuscript  for further review. I appreciate the revisions made
and the detailed responses to my previous comments. Below is my assessment of the revised
manuscript:
Updated Prevalence and Burden of NAFLD
I acknowledge that the prevalence of NAFLD has been updated in the Introduction section. The
manuscript now offers a more comprehensive and updated context.
Thank you for linking the TyG-WC index to insulin resistance  and explaining its connection
to the development of NAFLD in the Discussion. However, to make these relationships clearer,
I suggest incorporating a visual illustration that maps out the pathways from TyG index to IR,
and then from IR to the progression of NAFLD. Many studies have explored these pathways
and you can use them.
Also you can mention the role of obesity, particularly waist circumference, in this process. WC
is a key indicator of visceral fat and has a well-established link to IR and NAFLD progression
and you can add this information in your illustration.
Figure 5 Labels
Thank you for updating Figure 5. However, I was unable to open the new file. Please resend
it for review.
Overall, the revisions have improved the clarity and quality of the manuscript. However, I
suggest the addition of a visual mechanism illustration, as discussed above, to further strengthen
the paper.
Please review this paper.
user
Title: Triglyceride glucose waist circumference and Non alcoholic fatty liver disease: a
systematic review and meta analysis
Version: 1 Date: 30 Mar 2025
Reviewer's report:
Dear Authors,
Thank you for resubmitting your manuscript  for further review. I appreciate the revisions made
and the detailed responses to my previous comments. Below is my assessment of the revised
manuscript:
Updated Prevalence and Burden of NAFLD
I acknowledge that the prevalence of NAFLD has been updated in the Introduction section. The
manuscript now offers a more comprehensive and updated context.
Thank you for linking the TyG-WC index to insulin resistance  and explaining its connection
to the development of NAFLD in the Discussion. However, to make these relationships clearer,
I suggest incorporating a visual illustration that maps out the pathways from TyG index to IR,
and then from IR to the progression of NAFLD. Many studies have explored these pathways
and you can use them.
Also you can mention the role of obesity, particularly waist circumference, in this process. WC
is a key indicator of visceral fat and has a well-established link to IR and NAFLD progression
and you can add this information in your illustration.
Figure 5 Labels
Thank you for updating Figure 5. However, I was unable to open the new file. Please resend
it for review.
Overall, the revisions have improved the clarity and quality of the manuscript. However, I
suggest the addition of a visual mechanism illustration, as discussed above, to further strengthen
the paper.
assistant