Reviewer's report
Title:Early stage signet ring cell carcinoma of the colon examined by magnifying
endoscopy with narrow-band imaging: a case report
Version:2Date:15 May 2015
Reviewer: Kenshi Yao
Reviewer's report:
Major comments:
1. English used in the manuscript is not well written. The authors should revise
English asking a native speaker who is specialized in editing the scientific article.
2. Histopathological investigation need more information. The author investigate
the mucin phenotype using immunostaining in oder to demonstrate the
signet-ring cell carcinoma's phenotype.
3. At the last part of discussion, they mentioned that when the signet-ring cell
carcinoma could be diagnosed the patient would undergo laparoscopic resection
from the beginning. This discussion is somewhat problem from the ethical point.
If they take a biopsy and if they confirmed the presence of signet-ring cell
carcinoma, they patient should have been subjected to surgery.
Minor comments:
1. Please clarify if the sentence "The tumor cells infiltrated 250 micrometers into
the submucosal layer of the lymphatic vessels" in the abstract is correct. English
itself is difficult to understand.
2. The authors need to show whether they took a biopsy prior to endoscopic
resection. If not, why they did not take it.
3. With regard to magnifying NBI findings in the center of the lesion, they only
described microvascular pattern. Microsurface pattern should be shown there.
4. Histological findings of the resected specimens are poorly described. Vascular
invasion and lymphatic invasion should be described separately.
Reviewer's report
Title:Early stage signet ring cell carcinoma of the colon examined by magnifying
endoscopy with narrow-band imaging: a case report
Version:2Date:15 May 2015
Reviewer: Kenshi Yao
Reviewer's report:
Major comments:
1. English used in the manuscript is not well written. The authors should revise
English asking a native speaker who is specialized in editing the scientific article.
2. Histopathological investigation need more information. The author investigate
the mucin phenotype using immunostaining in oder to demonstrate the
signet-ring cell carcinoma's phenotype.
3. At the last part of discussion, they mentioned that when the signet-ring cell
carcinoma could be diagnosed the patient would undergo laparoscopic resection
from the beginning. This discussion is somewhat problem from the ethical point.
If they take a biopsy and if they confirmed the presence of signet-ring cell
carcinoma, they patient should have been subjected to surgery.
Minor comments:
1. Please clarify if the sentence "The tumor cells infiltrated 250 micrometers into
the submucosal layer of the lymphatic vessels" in the abstract is correct. English
itself is difficult to understand.
2. The authors need to show whether they took a biopsy prior to endoscopic
resection. If not, why they did not take it.
3. With regard to magnifying NBI findings in the center of the lesion, they only
described microvascular pattern. Microsurface pattern should be shown there.
4. Histological findings of the resected specimens are poorly described. Vascular
invasion and lymphatic invasion should be described separately.
Please review this paper.
user
Reviewer's report
Title:Early stage signet ring cell carcinoma of the colon examined by magnifying
endoscopy with narrow-band imaging: a case report
Version:2Date:15 May 2015
Reviewer: Kenshi Yao
Reviewer's report:
Major comments:
1. English used in the manuscript is not well written. The authors should revise
English asking a native speaker who is specialized in editing the scientific article.
2. Histopathological investigation need more information. The author investigate
the mucin phenotype using immunostaining in oder to demonstrate the
signet-ring cell carcinoma's phenotype.
3. At the last part of discussion, they mentioned that when the signet-ring cell
carcinoma could be diagnosed the patient would undergo laparoscopic resection
from the beginning. This discussion is somewhat problem from the ethical point.
If they take a biopsy and if they confirmed the presence of signet-ring cell
carcinoma, they patient should have been subjected to surgery.
Minor comments:
1. Please clarify if the sentence "The tumor cells infiltrated 250 micrometers into
the submucosal layer of the lymphatic vessels" in the abstract is correct. English
itself is difficult to understand.
2. The authors need to show whether they took a biopsy prior to endoscopic
resection. If not, why they did not take it.
3. With regard to magnifying NBI findings in the center of the lesion, they only
described microvascular pattern. Microsurface pattern should be shown there.
4. Histological findings of the resected specimens are poorly described. Vascular
invasion and lymphatic invasion should be described separately.
assistant