saponification: a chemical reaction in which an ester is heated with an alkali (especially the alkaline hydrolysis of a fat or oil to make soap)
physical entity: an entity that has physical existence
von willebrand's disease: a form of hemophilia discovered by Erik von Willebrand; a genetic disorder that is inherited as an autosomal recessive trait; characterized by a deficiency of the coagulation factor and by mucosal bleeding