task stringclasses 1
value | input stringlengths 11k 52.1k | target stringclasses 2
values | label_src stringclasses 1
value | article_id stringlengths 0 18 | domain stringclasses 5
values | n_rounds int64 2 6 |
|---|---|---|---|---|---|---|
outcome_prediction | Paper:
ABSTRACT:
Sluggish kinetics caused by 16-electron transfer hinders development of wide-temperature-range sodium-sulfur batteries. Here we report Sn-doped CoNiS multipods with an amorphous-crystalline interwoven structure. Employed as a positive electrode catalyst, the resulting sodium–sulfur battery exhibits a d... | STANDARD | heuristic | s41467-026-69749-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Fragile X-associated tremor/ataxia syndrome (FXTAS) is a neurodegenerative disorder caused by CGG repeat expansions in the FMR1 gene. While CGG repeat toxicity is established, the precise molecular mechanisms driving neurodegeneration remain unclear. Here, we show that a multi-omics strategy combined w... | STANDARD | heuristic | s41467-025-68163-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Autism spectrum disorders (ASD) are neurodevelopmental disorders associated with synaptic deficits. Oligodendrocyte precursor cells (OPCs) are the only type of glial cells that establish direct synaptic connections with neurons within the central nervous system (CNS). However, the mechanism that result... | STANDARD | heuristic | s41467-025-67930-y | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Co-fractionation mass spectrometry (CF-MS) enables large-scale profiling of endogenous protein-protein interactions, yet CF-MS data generation is of low throughput and therefore predictive models are often limited by the scarcity and limited diversity of high-quality training data. To address this, we ... | STANDARD | heuristic | s41467-026-68686-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Ribosomal protein mutations are increasingly associated with cancer risk and thought to perturb ribosome function. At the same time, they reportedly activate p53, a critical anti-cancer barrier. To determine how these mutations overcome this protective block to enable tumorigenesis, we generate an in v... | STANDARD | heuristic | s41467-026-70655-1 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Celiac disease (CeD) is an immune-mediated condition driven by dietary gluten resulting in small intestinal mucosal inflammation and injury, along with myriads of symptoms. The only treatment is a lifelong gluten-free diet (GFD) and although most patients improve, the restriction can lead to nutrient d... | STANDARD | heuristic | s41467-026-70644-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
NK cells are critical mediators of anti-tumor immunity whose function is frequently compromised in the tumor microenvironment. Here we identify SAM domain, SH3 domain and nuclear localization signals 1 (SAMSN1) as a previously unrecognized immune checkpoint that predominantly regulates NK cell function... | STANDARD | heuristic | s41467-026-68661-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The abnormal formation of the membrane attack complex (MAC) is intrinsically linked to a range of acute and chronic immune diseases. The insertion of complement C9 into the membrane is the final step and kinetic bottleneck of MAC formation. However, research on blocking the MAC formation of C9 is curre... | STANDARD | heuristic | s41467-026-70667-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Variations in blood protein levels have been linked to numerous complex diseases, including cardiovascular conditions. These associations highlight the intricate interplay between local and systemic factors in cardiovascular disease development, emphasizing the need for a comprehensive, systems-level u... | STANDARD | heuristic | s41467-025-67135-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
A central goal in neuroscience is to clarify how neural circuits translate sensory input into adaptive behaviours. Although unisensory evoked escape circuits in mice are well defined, it remains unclear whether a single nucleus contains specialized sensory, sensory‒motor decision, and motor command neu... | STANDARD | heuristic | s41467-026-70754-z | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Microglial capacity to adapt to tissue needs is a hallmark feature of these cells. New studies show that mitochondria critically regulate the phenotypic adaptability of macrophages. To determine whether these organelles play similar roles in shaping microglial phenotypes, we generated transgenic mouse ... | STANDARD | heuristic | s41467-025-66709-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Glucocorticoid-producing cells of the adrenal cortex (i.e. zona fasciculata, zF) constitute the critical effectors of the hypothalamic-pituitary-adrenal axis, mediating the mammalian stress response. With glucocorticoids being essential for life, zF dysfunction perturbs multiple organs that participate... | STANDARD | heuristic | s41467-025-68257-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Integrating nonlocal metasurfaces with thermal photonics has endowed thermal emissions with temporal and spatial coherence, as well as chirality. However, the static response of current thermal emitters hinders their broader applications, especially in high-precision sensing. Here, we present an anisot... | STANDARD | heuristic | s41467-026-70825-1 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Pulmonary group 2 innate lymphoid cells (ILC2s) are key drivers of Type 2 inflammation in diseases like asthma, yet the molecular mechanisms regulating their function are incompletely understood. Using the genetically diverse Collaborative Cross (CC) mouse panel, we mapped a quantitative trait locus (Q... | STANDARD | heuristic | s41467-025-67813-2 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Viruses are obligate intracellular parasites and viral infections lead to massive host cell rearrangement to support the rapid generation of progeny. Host take-over and remodelling include formation of viral-induced compartments for viral genome replication and/or assembly. While viruses infecting bact... | STANDARD | heuristic | s41467-026-71181-w | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The lysosome is a cell’s endogenous machinery responsible for degrading proteins. Here we describe two lysosome-targeting live attenuated vaccine approaches, LYTAR1.0 and LYTAR2.0, by harnessing the lysosome to conditionally degrade viral proteins of influenza virus. LYTAR1.0 incorporates a conditional... | STANDARD | heuristic | s41467-026-69920-0 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Interspecific brood parasitism has evolved repeatedly from parental care. However, many non-avian brood-parasitic lineages have ancestors lacking parental care, leaving the foundations of brood parasitism in these lineages enigmatic. We examine ecological, reproductive, and developmental data from the ... | STANDARD | heuristic | s41467-026-71179-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Macrophages are central drivers of chronic inflammation, yet how a sustained inflammatory state alters their function remains unclear. Using GFP knock-in zebrafish targeting irg1/acod1 that marks macrophage activation, we track the dynamic transitions of macrophages during acute muscle injury under hom... | STANDARD | heuristic | s41467-025-68204-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Predicting optoelectronic properties of large-scale atomistic systems under realistic conditions is crucial for rational materials design, yet computationally prohibitive with first-principles simulations. Recent neural network models have shown promise in overcoming these challenges, but typically req... | STANDARD | heuristic | s41467-026-70865-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Streptococcus pyogenes, or Group A Streptococcus (GAS), is a human pathogen responsible for a range of diseases, from mild infections to severe illnesses. Despite its significance in modern clinical settings, little is known about the pathogen’s evolutionary history or its presence in ancient human pop... | STANDARD | heuristic | s41467-026-71603-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The contribution of airway pathobionts to chronic respiratory disease is increasingly recognized, yet the evolutionary processes that shift commensals to pathogens remain poorly understood. Here we investigate how antibiotic pressure drives adaptation in Neisseria subflava, a common airway commensal as... | STANDARD | heuristic | s41467-026-68621-y | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The mitochondrial respiratory chain comprises four multimeric complexes (CI-CIV) that drive oxidative phosphorylation by transferring electrons to oxygen and generating the proton gradient required for ATP synthesis. These complexes can associate into supercomplexes (SCs), such as the CI+CIII₂+CIV resp... | STANDARD | heuristic | s41467-025-68274-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
We examined whether long-term exposure to visceral-adipose-tissue (VAT) influences brain atrophy and cognitive performance years after lifestyle intervention. In the Follow-Interventions-Trial (FIT) project, 533 adults (age=61.4y, 86% men) from four prior 18-24-month lifestyle randomized-clinical-trial... | STANDARD | heuristic | s41467-026-71141-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Exposure to airborne fine particulate matter (PM2.5) has been linked to increased risk of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, yet the underlying mechanisms remain unclear. Here, by leveraging a fine-tuned foundation model of single-cell transcriptomics, we uncove... | STANDARD | heuristic | s41467-026-71196-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Identifying drivers of cancer progression to guide treatment selection is hindered by our limited understanding of tumor heterogeneity and its impact on tumor evolution. Here, we delineate the phenotypic variability across ~300,000 cells collected from multiple tumor loci in primary prostate and matche... | STANDARD | heuristic | s41467-025-67856-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Peritoneal metastases (PM) occur in 10% of patients with colorectal cancer (CRC) and are linked to poor outcomes. Although dysregulated innate lymphoid cells (ILC) have been described in CRC, their function in CRC-PM remains unclear. Here, we analyze tumor samples from CRC and CRC-PM patients using sin... | STANDARD | heuristic | s41467-026-71085-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Centromeres are essential for kinetochore assembly and spindle attachment. While chromosomes of most species are monocentric with a single centromere, a minority exhibit holocentricity, with a centromere along the chromatid length. Sporadic emergence of holocentricity suggests multiple independent tran... | STANDARD | heuristic | s41467-025-67524-8 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Type I interferons restrict HIV-1 replication by inducing antiviral genes, but the full spectrum of their effectors remains incompletely defined. Here we identify ZFP36L2, a nuclear RNA-binding protein, as an IFN-β-induced inhibitor of HIV-1 infection. Silencing of ZFP36L2 impairs IFN-β-mediated HIV-1 ... | STANDARD | heuristic | s41467-026-71474-0 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Hypertensive heart failure highlights an urgent need for effective therapeutic strategies. Protein kinases regulate multiple pathways in cardiac pathophysiology and may provide promising therapeutic targets. Here, we identified a Cyclin-dependent kinase, CDK9, promoting inflammation and cardiac remodel... | STANDARD | heuristic | s41467-026-70410-6 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Mitochondrial DNA (mtDNA) mutations occur more frequently than nuclear mutations and are associated with various diseases. While single-cell sequencing enables mtDNA variant heteroplasmy analysis, a holistic view of mtDNA mutational landscapes in individual cells has remained limited. Here, we leverage... | STANDARD | heuristic | s41467-026-70399-y | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
When an organism learns that a sensory stimulus predicts a threat, the brain’s neural representation of the stimulus somehow incorporates that information into early sensory processing. That altered sensory processing may causally shape the organism’s response to the stimulus. We used contextual fear c... | STANDARD | heuristic | s41467-026-71356-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Conventional rechargeable zinc-air batteries (ZABs) face two critical challenges: (1) slow
kinetics of the oxygen reduction (ORR) and oxygen evolution (OER) reactions; and (2) the
thermodynamic incompatibility of OER and ORR occurring concurrently on a single air cathode.
To address these limitations, ... | STANDARD | heuristic | s41467-026-70736-1 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Chemotherapy often kills a large fraction of cancer cells but leaves behind a small population of drug-tolerant persister cells. These persister cells survive drug treatment through reversible, non-genetic mechanisms and cause tumour recurrence upon cessation of therapy. Here, we report a drug toleranc... | STANDARD | heuristic | s41467-025-65888-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Candidozyma auris is an emerging multidrug-resistant fungal pathogen that poses a major public-health challenge owing to high mortality and the limited efficacy of current therapies. Echinocandins, which inhibit β-glucan synthesis, are first-line therapy for invasive C. auris infection; however, resist... | STANDARD | heuristic | s41467-025-67022-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Predator-prey interactions determine food web structure, energy flux, and ecosystem stability. Increasing temperatures and commercial fishing both alter body size distributions that underpin predator-prey interactions, but empirical evidence of their individual and combined effects is limited. We study... | STANDARD | heuristic | s41467-025-67362-8 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Decision making is traditionally thought to be mediated by neurons that accumulate evidence through persistent activity. However, recent decision-making experiments in rodents have observed neurons across the brain that fire sequentially, rather than persistently, with the subset of neurons in the sequ... | STANDARD | heuristic | s41467-026-70267-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Global nitrogen (N) enrichment promotes soil organic carbon (SOC) accumulation but often causes biodiversity loss in plants and soil microbes, creating a central challenge for achieving co-benefits of carbon accumulation and biodiversity conservation. The extent to which biodiversity contributes to SOC... | STANDARD | heuristic | s41467-025-68090-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Senescent mesenchymal stem cells residing in an inflammatory, dysbiotic, and hypoxic microenvironment pose a barrier to periodontal regeneration. Here we introduce a hydrocaffeic acid (HCA)-mediated silk fibroin hydrogel incorporating Mn/HCA-modified calcium peroxide (Mn-hCaO₂) and HCA-modified zeoliti... | STANDARD | heuristic | s41467-026-70176-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Cells interpret mechanical cues from their microenvironment with spatio-temporal precision to guide adaptive behaviors. However, engineering synthetic mechanosensing systems with both cell-specificity and programmability remains challenging, especially when targeting ubiquitous classical mechanorecepto... | STANDARD | heuristic | s41467-026-70765-w | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Wastewater-based surveillance has emerged as a powerful tool for monitoring microbial diversity, antimicrobial resistance genes (ARGs) and mobile genetic elements (MGEs). In this study, wastewater samples collected from March 2022 to March 2024 from 19 locations in four metropolitan cities of India wer... | STANDARD | heuristic | s41467-026-70702-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
5-methylcytosine (5mC) DNA methylation is an ancient epigenetic mechanism. Methyl-CpG-binding domain protein 2 or 3 (MBD2/3) is a component of the Nucleosome Remodeling and Deacetylase (NuRD) complex, essential for gene regulation in mammals. The MBD2/3 ortholog is surprisingly preserved even in 5mC-fr... | STANDARD | heuristic | s41467-026-68592-0 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Recent decades have seen record-high temperatures on the Antarctic Peninsula (AP) due to combined atmospheric rivers (ARs) and föhn warming. While ARs frequently enhance föhn, not all events cause surface warming over the entire Larsen C Ice Shelf (LCIS). Using high-resolution Polar WRF simulations, we... | STANDARD | heuristic | s41467-026-71359-2 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Metal-Organic Frameworks (MOFs) have attracted widespread attention for their applications in water-related contexts. A comprehensive understanding of the molecular-level interactions between water and MOFs is crucial for guiding molecular design and optimizing water-related applications. Water can act... | STANDARD | heuristic | s41467-026-70247-z | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
We explore strategies to harness ancestral diversity in PsychENCODE Consortium Genotype-Expression (GEx) reference panels (adult and developing brain) and Psychiatric Genomics Consortium GWAS data to improve genetically regulated expression (GReX) models and their use for Transcriptome-wide association... | STANDARD | heuristic | s41467-025-67941-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Prostate cancer is a highly heterogeneous disease, driven by genomic and transcriptional changes that impact disease progression and metastatic potential. The interplay between clonal evolution, transcriptional plasticity, and tumour microenvironment is, however, poorly understood. Here, we leverage an... | STANDARD | heuristic | s41467-025-66704-w | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The mechanics of fracture healing in calcite remain poorly constrained yet are fundamental to managing fluid transport in geothermal reservoirs and hydrocarbon systems. Here, we apply microfocused synchrotron Laue X-ray diffraction and infrared spectroscopy to investigate subcritical crack healing in a... | STANDARD | heuristic | s41467-026-71110-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Intermittent fasting (IF) has gained attention as a potential intervention for cardiometabolic health, though its long-term effects remain unclear. In this randomized clinical trial, we assessed the impact of 6 months of IF on body composition, cardiovascular risk factors, and related molecular pathway... | STANDARD | heuristic | s41467-025-66366-8 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Human languages differ widely, yet they share systematic regularities in the underlying semantic representations being expressed. How such similarities and differences arise remains unclear, in part because semantic theories often lack a principled link to neurocognitive constraints. Drawing on neuroco... | STANDARD | heuristic | s41467-026-70608-8 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The molecular control and ancestral state of dorsal–ventral patterning within spiralians remain unclear due to the remarkable diversity across species. Here we present a chromosome-level genome for the brachiopod Lingula anatina and apply functional transcriptomics to study dorsal–ventral patterning un... | STANDARD | heuristic | s41467-026-70403-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The realization of high-efficiency thick-film organic solar cells (OSCs) is crucial for scalable manufacturing yet remains challenging due to limited exciton diffusion. Here, we introduce a magnetic strategy by incorporating two-dimensional (2D) ferromagnetic MoPS3 nanocrystal into the active layer to ... | STANDARD | heuristic | s41467-026-70320-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
This single-arm, open-label phase 1 trial evaluated the PPARγ agonist pioglitazone in patients with
inclusion body myositis (IBM). After a 16-week observation (lead-in) period, participants received
pioglitazone 45 mg daily for 32 weeks. The primary outcome was the change in PPARGC1A expression
and rel... | STANDARD | heuristic | s41467-026-70262-0 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Asparagine synthetase B (AS-B) is essential for nitrogen metabolism, but its broader physiological functions remain poorly understood. Here we show that the evolutionarily conserved Nicotiana benthamiana NbAS-B confers expression-dependent antiviral resistance and promotes plant growth. Multi-omics ana... | STANDARD | heuristic | s41467-026-70753-0 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Old World orthohantaviruses, including Hantaan virus (HTNV), cause hemorrhagic fever with renal syndrome (HFRS) in Eurasia. Available inactivated vaccines often induce low neutralizing antibodies and short-term protection. We evaluated nucleic acid vaccines expressing a prefusion-stabilized HTNV glycop... | STANDARD | heuristic | s41467-026-70285-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Thermogenic activation of subcutaneous white adipocytes requires glycogen synthesis and turnover. Here we show that β-adrenergic stimulation induces a distinct glycogen metabolism gene program in inguinal white adipose tissue in a cell-autonomous and adipocyte-specific manner. Among these, Gys2 and Ppp... | STANDARD | heuristic | s41467-025-67515-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Direct photosynthesis of hydrogen peroxide (H2O2) from air and water using metal/covalent-organic frameworks offers a sustainable alternative to the conventional energy-intensive anthraquinone process. However, current systems suffer from short operational lifetimes typically 10–100 h due to mismatch b... | STANDARD | heuristic | s41467-026-70693-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Lunar mare basalts are often rich in titanium, hosted predominantly within the mineral ilmenite (Fe2+Ti4+O3). Here, we examine ilmenite in a ~3.8 billion-year-old mare basalt (Apollo rock 75035) using high-resolution electron microscopy and electron energy loss spectroscopy. A key finding is that 75035... | STANDARD | heuristic | s41467-026-69770-w | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
C H and CH are essential for industrial applications. However, contamination with other natural gases is a
2 4 4
challenge to their utilization. Although several sorbents have been investigated, their performance remains limited.
This study introduces graphene-inspired, PPN-20, a porous polymer network... | STANDARD | heuristic | s41467-026-70471-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The development of miniaturized waveplates is foundational to the continued scaling of integrated photonic and polarization-resolved optical systems. However, when commercial waveplates are scaled to reduced dimensions, they become constrained by intrinsically weak optical anisotropy, scattering losses... | STANDARD | heuristic | s41467-026-70788-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Intermittent fasting (IF) has emerged as a potential cancer treatment modality, although its tumor-suppressive effects are limited. Glioblastoma (GBM) can be classified into CDKN2A subtype and TP53 subtype. Here, we discover that the efficacy of IF is correlated with tumor subtypes of GBM. IF significa... | STANDARD | heuristic | s41467-026-68512-2 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Understanding and correlation of the multiscale interfacial mass transport behaviors mediated by the additive for liquid/liquid dispersion system is challenging. Here, we propose interfacial mass transfer flux through the quantitative coupling between microscopic interfacial parameters and mesoscopic d... | STANDARD | heuristic | s41467-026-70828-y | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Annotation of regulatory elements is essential for understanding mechanisms underlying gene regulation, particularly tissue-specific regulation in human and animals. Here, we characterize 274,682 enhancers and 25,975 promoters across 24 tissues from an adult female sheep using ChIP-seq, ATAC-seq, CAGE-... | STANDARD | heuristic | s41467-026-70382-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Transcranial ultrasound stimulation (TUS) is an emerging method for non-invasive neuromodulation of deep brain structures. However, to date, there is no evidence that TUS can directly modulate disease-related pathological oscillations in the same direction as known therapies. Inspired by clinical deep ... | STANDARD | heuristic | s41467-026-70714-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Efficient antigen delivery to B cells and dendritic cells (DC) is critical for enhancing vaccine immunogenicity. Here, we develop a dimeric vaccine strategy by fusing antigens to the N-terminal of heat shock protein GP96. This platform generates compact, nanoscale particles that fully exposed antigenic... | STANDARD | heuristic | s41467-025-67092-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Boron-dipyrromethenes(BODIPYs)areversatilefluorophoreswithintense
fluorescenceandbroadapplicationsinbioimagingandsensing.However,they
undergodeboronationunderacidicconditions,whichcausesfluorescence
degradation.Herein,wedesignedexceptionallyacid-stableBODIPYsbyhar-
nessingthesynergisticboron-chelatione... | STANDARD | heuristic | s41467-026-70499-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Effective host defense against pathogens requires coordinated behavioral and immune responses, yet the mechanisms that couple epithelial sensing to these systemic defenses remain poorly understood. Here we identify a proton-mediated gut-to-neuron signaling pathway that orchestrates host defense in C. e... | STANDARD | heuristic | s41467-026-71088-6 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Wireless sensing systems enable real-time, non-contact monitoring for next-generation intelligent platforms. Ideal wireless sensing systems feature compact, low power consumption, and long communication range. Here we report a miniaturized wireless sensing system with an in tegrated acoustic-resonance-... | STANDARD | heuristic | s41467-026-70058-2 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Aqueous microdroplets have fascinated scientists with unique properties that deviate from bulk solutions. Understanding microdroplet chemistry has been limited by few spectroscopic measurements on single well-defined microdroplets. Here we present a new technique to record an IR spectrum of a single dr... | STANDARD | heuristic | s41467-026-70299-1 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Zygnematophytes are the closest algal relatives of land plants. They hold key information to infer how the earliest land plants overcame the barrage of terrestrial stressors, the prime of which is osmotic stress. Here, we apply two osmotic stressors on a unicellular and a multicellular representative o... | STANDARD | heuristic | s41467-026-68329-z | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Photodetectors with high photoresponsivity are crucial in a wide range of emerging fields.
Here, we report the realization of photodetectors based on co-assembled composite
membranes consisting of copper phthalocyanine (CuPc) molecules and graphene oxide (GO)
sheets, showing a photoresponsivity as high... | STANDARD | heuristic | s41467-026-70950-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
In response to anthropogenic forcing, the Earth’s surface generally warms as greenhouse gases trap outgoing longwave radiation. Counterintuitively, however, some regions exhibit surface cooling against this global warming background—a phenomenon known as a warming hole. Beyond the well-documented warmi... | STANDARD | heuristic | s41467-026-69875-2 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The Shumagin Gap, a creeping segment of the Alaska subduction zone characterized by tsunamigenic structures, experienced a deep rupture during the July 2020 M7.8 earthquake. However, shallow slip behavior and the upper boundary of the rupture remain poorly understood. Here we utilize controlled-source ... | STANDARD | heuristic | s41467-026-71176-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Insects are crucial to ecosystem functioning but face numerous threats, with invasive alien species likely among the most severe. As insect declines continue, there is a growing need to synthesise evidence on how invasive alien species affect insects, as research has historically focused more on insect... | STANDARD | heuristic | s41467-025-67925-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Corollary discharge denotes internal signals about the expected sensory consequences of one’s own actions, leading to reduced sensory responses to self-generated stimulation. To investigate the underlying neural circuit mechanism, here we introduce a biologically plausible three-factor learning rule, w... | STANDARD | heuristic | s41467-026-70354-x | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
PG-102 is a potency-optimized bispecific Fc fusion protein targeting GLP-1 and GLP-2 receptors.
In db/db mouse models of advanced diabetes characterized by uncontrolled hyperglycemia and catabolic
weight loss, PG-102 achieved superior and sustained glycemic control compared with semaglutide or
tirzepat... | STANDARD | heuristic | s41467-026-71080-0 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
CRISPR/Cas9 technologies provide unique capabilities for modeling disease and understanding gene-to-phenotype connections. In cultured cells, chemical-mediated control of Cas9 activity can limit off-target effects and enable mechanistic study of essential genes. However, widely-used Tet-On systems ofte... | STANDARD | heuristic | s41467-025-67201-w | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Infective endocarditis (IE) is a severe heart infection caused predominantly by Gram-positive bacteria forming biofilm on heart valves. While biofilm formation is central to disease progression, the underlying bacterial mechanisms remain poorly understood. Here, we identify the Fsr quorum sensing (QS) ... | STANDARD | heuristic | s41467-026-68366-8 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
As climate warming accelerates, shifts in plant phenology are reshaping the functioning and stability of terrestrial ecosystems. While the roles of climatic drivers in shaping phenological responses to warming are well established, the influence of intrinsic plant functional traits remains poorly under... | STANDARD | heuristic | s41467-026-70474-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Mitochondrial genomes of some animals remained almost unchanged architecturally for over half a billion of years, while other lineages exhibit conspecific variability. The drivers underlying this disparity remain unknown. We analyse over 10,000 bilaterian mitogenomes to test whether locomotory capacity... | STANDARD | heuristic | s41467-026-70576-z | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Ischemic stroke presents a dual therapeutic challenge, involving dynamic and compartmentalized pathology in both the peripheral immune system and the central nervous system. Departing from conventional holistic treatment strategies, we developed a spatially tiered drug delivery approach using a combina... | STANDARD | heuristic | s41467-026-70340-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Efficient fatty acid (FA) re-esterification is essential for lipid homeostasis in adipocytes, yet the mechanisms coordinating Coenzyme A (CoA) availability at the endoplasmic reticulum (ER)—a major site of lipid synthesis—remain unclear. Here, we identify TMEM120A as an ER-resident CoA-binding protein ... | STANDARD | heuristic | s41467-025-67870-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Gap junctions, formed by connexin proteins, establish direct electrical and metabolic coupling between cells, enabling coordinated tissue responses. These channels universally respond to intracellular pH changes, closing under acidic conditions to limit the spread of cytotoxic signals during cellular s... | STANDARD | heuristic | s41467-026-68311-9 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The growing antibiotic resistance and high mortality rates associated with methicillin-resistant
Staphylococcus aureus (MRSA) pose a global health threat, highlighting the urgent need for novel
therapeutic strategies. Phenol-soluble modulin α3 (PSMα3) is a critical virulence factor in MRSA
pathogenesis... | STANDARD | heuristic | s41467-026-71029-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Mammals can now be cloned artificially, but it remains unknown whether they can also maintain their species through cloning. Herein, we continued serial cloning for 20 years from a single donor mouse. These re-cloned mice appeared normal and had normal lifespans, but large structural and lethal mutatio... | STANDARD | heuristic | s41467-026-69765-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Glasses,amorphoussolidphasesnearlyalwaysoutofequilibrium,remain
poorlyunderstooddespiterecentprogress.Hereweshowbyquantitativereal-spaceexperimentsandcomputersimulationstheexistenceofanequilibrium
glass-formingphasewhichformsduetoasubtleinterplaybetweentherota-tionalandtranslationaldegreesoffreedominas... | STANDARD | heuristic | s41467-026-70295-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
RAF activation is essential for MAPK signaling and is mediated by RAS binding and the dephosphorylation of a conserved phosphoserine by the SHOC2–RAS–PP1C complex. MRAS forms a high-affinity SHOC2–MRAS–PP1C (SMP) complex, while canonical RAS isoforms (KRAS, HRAS, NRAS) form analogous but lower-affinity... | STANDARD | heuristic | s41467-026-68319-1 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Cyclin-dependent kinase 4/6 inhibitors (CDK4/6i) combined with endocrine therapy are the standard first-line treatment for hormone receptor-positive, HER2−negative (HR+/HER2−) metastatic breast cancer, but resistance inevitably develops. In triple-negative breast cancer (TNBC), the efficacy of CDK4/6i ... | STANDARD | heuristic | s41467-025-67865-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Intrahepatic cholangiocarcinoma (ICC) features poor survival due to frequent recurrences and limited prognostic markers. Using mass spectrometry-based proteomics, we analyze two independent cohorts comprising 80 and 62 treatment-naive ICC tumors, along with 9 independent patient-derived xenografts (PDX... | STANDARD | heuristic | s41467-026-70817-1 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Microscopic vascular invasion (VI) predicts recurrence and benefit from lobectomy in stage I lung adenocarcinoma (LUAD) but cannot be accurately predicted before surgery. Thus, biomarkers that identify this aggressive tumor subset are needed. Here, we show that VI in stage I LUAD is associated with rep... | STANDARD | heuristic | s41467-026-70600-2 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Sustainable batteries necessitate high-performance hard carbon negative electrodes derived from abundant biomass. However, realizing their full potential is significantly limited by the inherent diversity of biomass feedstocks, the intricate control over carbonization and resulting microstructures, and... | STANDARD | heuristic | s41467-026-70411-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Humans and animals memorize and recognize familiar conspecifics during social interactions, known as social memory. While the hippocampus is crucial for social memory, the dynamic regulation of social memory remains unclear. Here, using male mice, we identified two molecularly distinct subpopulations o... | STANDARD | heuristic | s41467-026-69955-3 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
A central tenet of biology is that protein structure mediates the sequence-function relationship. Recently, there has been excitement about the promise of advances in protein structure modeling to generate hypotheses about sequence-structure-function relationships. Here, we leverage structural similari... | STANDARD | heuristic | s41467-026-71206-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
To advance toward commercial viability, sodium-ion batteries are required to operate under high cut-off voltages and low temperatures. This necessitates electrolyte designs that provide sufficient oxidative stability for high-voltage cycling while maintaining high ionic conductivity at low temperatures... | STANDARD | heuristic | s41467-026-70592-z | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Sessile plants rely on individual cells to perceive pathogens and coordinate defense. Guard cells (GCs), best known for regulating stomatal aperture, h ave poorly understood intrinsic immune roles. Here, we integrate single-cell and spatial analyLses of Arabidopsis thaliana leaves infected with diverse... | STANDARD | heuristic | s41467-026-70843-z | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
In populations of many animal species, including humans, mortality rates increase exponentially with advancing age. The scale and rate of increase can be set by two parameters, α and β, respectively, of the Gompertz equation. Interventions that extend lifespan can reduce either or both parameters. A lo... | STANDARD | heuristic | s41467-026-71780-7 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Deep learning has demonstrated remarkable abilities in restoring fluorescence microscopy images degraded by noise, blur, or undersampling. However, most existing models are task-specific and trained on limited, homogeneously distributed data, which restricts their generalizability and practicality. Her... | STANDARD | heuristic | s41467-026-70307-4 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
The 26S proteasome is the major eukaryotic protease responsible for the degradation of
misfolded, damaged, and obsolete regulatory proteins. Commitment to degradation occurs when
conserved pore loops in the heterohexameric ATPase motor of the proteasome engage the
flexible initiation region of a polyub... | STANDARD | heuristic | s41467-026-70426-y | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Comparative studies of vertebrate appendages offer a powerful framework for uncovering shared components of an ancestral regeneration toolkit. Here, we employed a multi-omics comparative approach leveraging the regenerative capacity of the axolotl, zebrafish, and Polypterus senegalus, a fish capable of... | STANDARD | heuristic | s41467-026-68801-w | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
High-nickel layered positive electrodes suffer from progressive structural degradation arising from lattice oxygen loss and inherent lattice strain. Although surface coatings are widely used to stabilize lattice-oxygen redox and mitigate electro-chemo-mechanical degradation, achieving coatings with ful... | STANDARD | heuristic | s41467-026-70616-8 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Integrating functional nanostructures onto diverse three-dimensional surfaces is important for a wide range of applications, including holography, sensors, and extended reality. Nanotransfer printing (nTP) has emerged as a leading approach owing to its high throughput and resolution. However, conventio... | STANDARD | heuristic | s41467-026-70902-5 | biology | 2 |
outcome_prediction | Paper:
ABSTRACT:
Elevated temperatures pose challenges to stomatal conductance, which regulates transpiration and photosynthesis. However, the coupling of stomatal conductance, transpiration and photosynthesis may shift with warming. Here, we synthesize evidence from a meta-analysis of 207 studies to assess leaf physio... | STANDARD | heuristic | s41467-025-68250-x | biology | 2 |
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