
    study cancelled as of 9/12/15. 0 subjects enrolled.
  
['diabetic retinopathy']
['squalamine lactate ophthalmic solution 0.2%']

        Inclusion Criteria:

          -  Subjects will have clinically significant diabetic macular edema of ≥ 300 microns with
             central involvement using the Heidelberg or Cirrus machine

          -  Best corrected visual acuity of 20/32 to 20/320 inclusive in the study eye

          -  Adults ≥ 18 years of age with type 1 or 2 diabetes mellitus with diabetic macular
             edema

        Exclusion Criteria:

          -  History of vitreoretinal surgery in the study eye

          -  Panretinal laser photocoagulation or macular laser photocoagulation in the study eye
             within 3 months of screening

          -  Any prior laser in study eye

          -  Previous use of intraocular or periocular corticosteroids in the study eye within 6
             months of screening

          -  Previous treatment with anti-angiogenic drugs in either eye within 3 months of
             screening

          -  Uncontrolled diabetes mellitus with HbA1c levels greater than 12

          -  Ocular disorders in the study eye, other than diabetic macular edema, that my confound
             interpretation of study results
      