
    lack of efficacy and funding to continue investigation
  
['pancreatic cancer']
['cyclophosphamide']

        Inclusion Criteria:

          -  Signed informed consent

          -  Unresectable or metastatic pancreatic cancer

          -  Persistent cancer after at least one prior standard of care chemotherapy for advanced
             stage disease

          -  18 years of age and older

          -  ECOG performance status of 0 or 1

          -  Life expectancy greater than 3 months

          -  Satisfactory organ and bone marrow function

          -  Meets blood coagulation parameters

          -  Male and Female subjects of reproductive potential agree to use approved contraceptive
             methods

        Exclusion Criteria:

          -  Participation in a therapeutic investigational study within 4 weeks prior to the
             screening visit

          -  Anticipated need for systemic chemotherapy within 2 weeks before apheresis and
             infusion

          -  Active invasive cancer other than pancreatic cancer

          -  HIV, HCV, or HBV infections

          -  Active autoimmune disease requiring immunosuppressive therapy within 4 weeks prior to
             screening visit, with exception of thyroid replacement

          -  Ongoing or active infection

          -  Planned concurrent treatment with systemic high dose corticosteroids

          -  Patients requiring supplemental oxygen therapy

          -  Prior therapy with gene modified cells

          -  Previous experimental therapy with SS1 moiety, murine or chimeric antibodies

          -  History of allergy to murine proteins

          -  History of allergy or hypersensitivity to study product excipients (human serum
             albumin, DMSO, and Dextran 40)

          -  Clinically significant pericardial effusion, CHF, or cardiovascular condition that
             would preclude assessment of mesothelin induced pericarditis or that may worsen as a
             result of toxicities expected for this study

          -  Pregnant or breastfeeding women
      