['type 2 diabetes']
['isis-gcgrrx- dose level 1', 'isis-gcgrrx- dose level 2', 'placebo']

        Inclusion Criteria:

          -  Male or female, age 18 to 75

          -  BMI ≥ 25.0 kg/m2

          -  HbA1c ≥ 8.0% and ≤ 10.5%

          -  Type 2 Diabetes Mellitus and on stable dose of Metformin

          -  Agree to conduct home-based (fasted) blood glucose testing as directed

        Exclusion Criteria:

          -  Clinically significant abnormalities in medical history of physical exam

          -  Show evidence of uncorrected hypothyroidism or hyperthyroidism hormone results

          -  History of solid organ transplant or renal dialysis

          -  History of liver disease

          -  History of greater than 3 episodes of severe hypoglycemia within 6 months of screening

          -  Treatment with any other antidiabetic drug(s) other than metformin within 3 months of
             screening

          -  History of diabetic ketoacidosis

          -  Any other significant illness or condition that may interfere with the patient
             participating or completing the study

          -  Inability or unwillingness to comply with protocol or study procedures
      