
    it's too slow to enroll suitable patients into this study
  
['breast cancer']
['bicalutamide']

        Inclusion Criteria:

          1. Females elder than 18

          2. Histological proven unresectable or metastatic breast cancer patients who underwent at
             least one chemotherapy regimen for metastatic disease

          3. Patients with androgen Receptor (AR) positive (IHC >10% nuclear staining) either for
             primary tumor or metastatic lesion

          4. Triple-negative for estrogen receptor (ER), progestogen receptor (PR), and human
             epithelial receptor-2 (HER2) by IHC (ER <1%, PR <1% and Her2 negative). A negative
             Her2 gene amplification should be verified by FISH test for those patients with Her2
             (2+). For those with Her2 (1+), FISH test might be considered by the investigator.

          5. At least one measurable disease according to the response evaluation criteria in solid
             tumor (RECIST 1.1)

          6. Performance status no more than 2

          7. All patients enrolled are required to have adequate hematologic, hepatic, and renal
             function

          8. Life expectancy longer than 12 weeks

          9. No serious medical history of heart, lung, liver and kidney

         10. Be able to understand the study procedures and sign informed consent.

         11. Patients with good compliance

        Exclusion Criteria:

          1. Pregnant or lactating women

          2. Women of child-bearing potential, unwilling to use adequate contraceptive protection
             during the process of the study

          3. Patients treated with an investigational product within 4 weeks before the enrollment

          4. Patients who received chemotherapy within 4 weeks before the enrollment

          5. Patients with symptomatic central nervous system metastases are not permitted, except
             for those with stable and asymptomatic brain metastases who have completed cranial
             irradiation, and have at least one measurable lesion outside the brain. Radiotherapy
             should be completed within 4 weeks prior to the registration

          6. Other active malignancies (including other hematologic malignancies) or other
             malignancies within the last 5 years, except for cured nonmelanoma skin cancer or
             cervical intraepithelial neoplasia.

          7. Patients having a history of clinically significant cardiovascular, hepatic,
             respiratory or renal diseases, clinically significant hematological and endocrinal
             abnormalities, clinically significant neurological or psychiatric conditions

          8. Uncontrolled serious infection
      