['myocardial ischemia']
['heme arginate 3mg/kg', 'heme arginate 1mg/kg', 'placebo']

        Inclusion criteria:

          -  Signed informed consent

          -  Men and women aged between 40 and 85 years (inclusive)

          -  Body mass index < 35 kg/m2

          -  Ability to communicate well with the investigator in the local language and to
             understand and comply with the requirements of the study

        Exclusion criteria (any of the following):

          -  Known hypersensitivity to the study drug or any excipients of the drug formulation

          -  Treatment with another investigational drug within 3 weeks prior to screening

          -  History or clinical evidence of any disease and/or existence of any surgical or
             medical condition, which might interfere with the absorption, distribution, metabolism
             or excretion of the study drug

          -  Severe renal failure (glomerula filtration rate < 30 ml/min)

          -  Moderately or severe impaired left ventricular function (ejection fraction < 40%)

          -  Moderately or severe impaired right ventricular function

          -  Systolic pulmonary pressure > 45 mmHg

          -  Acute or recent (<7 days) myocardial infarction

          -  Child bearing potential
      