
    due to enrollment challenges and availability of other options for lung cancer patients. the
    termination is not a consequence of any safety concern.
  
['squamous cell carcinoma']
['selinexor (kpt-330)']

        Inclusion Criteria:

          -  18 years of age or older

          -  confirmed SCC of the head and neck, lung, or esophagus

          -  1 to 2 prior therapies

          -  measurable disease at screening and documented progression within the past 6 weeks

        Exclusion Criteria:

          -  patients requiring total parenteral nutrition

          -  unstable cardiovascular function

          -  substantially impaired gastrointestinal function

          -  Symptomatic brain metastases

          -  another malignancy within 3 years except adequately treated in situ carcinoma of any
             type, basal or non-melanomatous skin cancer
      