['chronic idiopathic constipation']
['linaclotide', 'matching placebo']

        Inclusion Criteria:

          -  Patient has completed a colonoscopy if one is needed according to the American
             Gastroenterological Association (AGA) criteria, with no clinically significant
             findings

          -  Patient has no clinically significant findings on a physical examination and clinical
             laboratory tests

          -  Patient meets protocol criteria for CIC: reports < 3 bowel movements (BMs) per week
             and reports one or more of the following during ≥ 25% of BMs: straining, lumpy or hard
             stools, sensation of incomplete evacuation during the 3 months before the diagnosis
             with the onset at least 6 months before the diagnosis

          -  Patient is compliant with daily interactive voice response system (IVRS) calls

          -  Patient reports an average of < 3 complete spontaneous BMs (CSBMs) and ≤ 6 SBMs per
             week by the IVRS over the 14 calendar days before the Randomization Visit and the
             calendar day of Randomization.

        Exclusion Criteria:

          -  Patient has history of loose or watery stools

          -  Patient has symptoms of or been diagnosed with irritable bowel syndrome (IBS)

          -  Patient has a structural abnormality of the gastrointestinal (GI) tract or a disease
             or condition that can affect GI motility

          -  Patient has any protocol-excluded or clinically significant medical or surgical
             history that could confound the study assessments

          -  Patient has Bristol Stool Form Scale score of 7 during Pretreatment period.
      