['chronic obstructive pulmonary disease']
['chf 5259', 'placebo']

        Inclusion Criteria:

          -  Male and female adults (40 ≤ age ≤ 80 years) with a diagnosis of COPD

          -  Current smokers or ex-smokers

          -  A post-bronchodilator FEV1 < 60% of the predicted normal value and a
             post-bronchodilator FEV1/FVC < 0.7

          -  Positive response to the reversibility test at screening defined as change in FEV1 ≥
             5%.

          -  BDI score ≤ 10

          -  Patients free of exacerbations for at least 1 month

        Exclusion Criteria:

          -  Pregnant or lactating women

          -  Diagnosis of asthma

          -  Patients treated for exacerbations in the 4 weeks prior to screening visit

          -  Patients treated with long-acting antihistamines unless taken at stable regimen at
             least 2 months prior to screening and to be maintained constant during the study or if
             taken as PRN

          -  Patients requiring long term (at least 12 hours daily) oxygen therapy for chronic
             hypoxemia

          -  Known respiratory disorders other than COPD

          -  Patients who have clinically significant cardiovascular condition
      