['arthroplasty, replacement, knee']
['ep=7041', 'placebo']

        Inclusion Criteria:

          -  Male or female, non-smoker (no use of tobacco products within 3 months prior to
             screening), ≥18 and ≤60 years of age, with Body Mass Index (BMI) > 18.5 and < 32.0
             kg/m2 and a weight of at least 60 kg but not greater than 100 kg.

          -  Healthy as defined by:

               1. No history of abnormal bleeding episodes, e.g. nosebleeds, or abnormally heavy
                  periods, or extensive bleeding after injury, surgery or dental work.

               2. A normal short physical examination and normal vital signs (heart rate (HR),
                  blood pressure (BP) and tympanic body temperature).

               3. Normal laboratory tests (hematology, biochemistry, urinalysis, coagulation tests
                  (aPTT and PT).

               4. the absence of clinically significant illness and surgery within 4 weeks prior to
                  dosing.

               5. the absence of clinically significant history of neurological, endocrinal,
                  cardiovascular, pulmonary, hematological, immunologic, psychiatric,
                  gastrointestinal, renal, hepatic, and metabolic disease.

        Exclusion Criteria:

          -  Any clinically significant abnormality or abnormal laboratory test results found
             during medical screening which, at the investigator's discretion, warrants exclusion
             or positive test for hepatitis B, hepatitis C, or HIV.

          -  Use of any drugs known to induce or inhibit hepatic drug metabolism within 30 days
             prior to drug administration.

          -  Positive pregnancy test at screening or check-in (Day -1).

          -  Clinically significant ECG abnormalities or vital sign abnormalities (systolic blood
             pressure lower than 90 or over 160 mmHg, diastolic blood pressure lower than 50 or
             over 90 mmHg, or heart rate less than 40 or over 100 bpm) at screening or check-in
             (Day -1).

          -  Participation in a clinical trial involving the administration of an investigational
             or marketed drug within 30 days (90 days for biologics), or five (5) half-lives,
             whichever is longer, prior to the first dosing or concomitant participation in an
             investigational study involving no drug administration.

          -  Hemoglobin or hematocrit clinically significantly less than lower limits of normal at
             screening.
      