['glioblastoma', 'glioma', 'brain tumor']
['carboplatin']

        Inclusion criteria:

          -  Age greater than 18 years.

          -  Subjects with recurrent glioma who have failed standard therapy with surgery and/or
             treatment with radiation and temozolomide.

          -  Patient eligible for Carboplatin-based chemotherapy

          -  Contrast-enhanced tumor less than 35 mm in diameter

          -  No risk of cerebral herniation

          -  Able to tolerate pre/post procedure steroid treatment

          -  Social security affiliated (in France)

          -  Able and willing to give signed and informed consent

          -  Normal biological status

          -  Hemoglobin ≥ 10 g/dl

          -  Platelets ≥ 100000/mm3

          -  Neutrophils ≥ 1500/mm3

          -  Normal creatine clearance ≥ 60ml/mn

          -  ASAT < 3 N

          -  ALAT < 3 N

          -  Normal Bilirubin Level < 1.5 N

          -  Alkaline Phosphatase < 3 N

          -  INR < 1.5

          -  Prothrombin Level ≥ 70%

        Exclusion criteria:

          -  Allergic to Iodine, Gadolinium, Xylocain

          -  Contra-indications to echographic contrast agent (microbubbles)

          -  Severe Renal insufficiency

          -  Hepatic insufficiency

          -  Possible toxic treatment for CNS

          -  Previously infected surgical field

          -  Uncontrolled epilepsy

          -  MRI contra-indications

          -  Hemostasis troubles thrombopenia <75.000, TP <60%, INR >1.5, anti-platelet or
             anticoagulant therapy on-going)

          -  Active phlebitis or active pulmonary embolism

          -  Pregnant or currently breast-feeding

          -  Patients under judicial protection
      