['coronary artery disease', 'clopidogrel, poor metabolism of']
['clopidogrel', 'ticagrelor']

        Inclusion Criteria:

          1. Patients with oral clopidogrel treatment admitted to hospital within 24 hours or
             long-term follow-up outpatients with oral clopidogrel treatment;

          2. The platelet aggregation rate (PAgR) measured with light transmission aggregometry
             (LTA) is decreased no more than 10% from baseline level, or PAgR is more than 46% and
             the percentage of inhibition of ADP-induced platelet aggregation measured by
             thrombelastogram is not more than 30%;

        Exclusion Criteria:

          1. Planned use of glycoprotein IIb/IIIa receptor inhibitors, adenosine diphosphate (ADP)
             receptor antagonists, or anticoagulant therapy during the study period;

          2. Platelet count <100g/L;

          3. Creatinine clearance rate < 30ml/min;

          4. Diagnosed as respiratory or circulatory instability (cardiac shock, severe congestive
             heart failure NYHA II-IV or left ventricular ejection fraction < 40%);

          5. A history of bleeding tendency;

          6. Aspirin, ticagrelor or clopidogrel allergies;

          7. Severe liver injury.
      