['metastatic breast cancer']
['docetaxel', 'fulvestrant']

        Inclusion Criteria:

          -  Postmenopausal female between 18 and 70 years old

          -  ECOG performance status of ≤ 1

          -  Life expectancy more than 3 months

          -  Histologically confirmed metastatic breast cancer

          -  ER and&or PR pqositive, HER2-negative

          -  Disease progression during adjuvant or first-line endocrine therapy, or endocrine
             naive but unsuitable for endocrine therapy alone

          -  No pretreated chemotherapy for metastatic disease

          -  Have at least one target lesion according to RECIST 1.1

          -  No therapy (chemotherapy, endocrine therapy, target therapy and operation) within 4
             weeks before enrollment

          -  Hemoglobin ≥ 90 g/L, Absolute Neutrophil Count ≥ 1.5×10^9/L, Platelet Count ≥
             75×10^9/L, Serum Bilirubin ≤ 1.5×ULN, ALT and AST ≤ 1.5×ULN, Serum Creatinine ≤ 1×ULN,
             Endogenous Creatinine Clearance>50ml/min

        Exclusion Criteria:

          -  Pregnant or lactating women

          -  Evidence of CNS metastasis

          -  Seriously uncontrolled infection

          -  History of another malignancies except cured basal cell carcinoma of skin and
             carcinoma in-situ of uterine cervix

          -  Pretreated with Fulvestrant

          -  Pretreated with two or more lines of endocrine therapy
      