
    this study was terminated due to the benefit-risk balance of mt-4666.
  
["alzheimer's disease"]
['mt-4666']

        Inclusion Criteria:

          -  Probable Alzheimer's disease consistent with the National Institute on Aging and the
             Alzheimer's Association Criteria for Diagnosis of Alzheimer's Disease (McKhann et al.
             2011).

          -  MMSE score of ≥ 14 and ≤ 24 at the screening and ≥ 12 and ≤ 26 at the baseline.

          -  Modified Hachinski Ischemic Score (mHIS) ≤ 4 at the screening

          -  Appropriate caregiver available

          -  Subject living at home or in facilities who do not require continuous (24-hour)
             nursing care.

        Exclusion Criteria:

          -  Diagnosis of any other disease which may cause dementia

          -  Diagnosis of major depressive disorder as defined by Diagnostic and Statistical Manual
             of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) within last five years

          -  History of or current diagnosis of any psychosis

          -  History of myocardial infarction or unstable angina within six months before screening

          -  History of cerebrovascular disorder within 18 months before screening

          -  complication of hepatic disorder or renal dysfunction
      