['crohn disease']
['thalidomide', 'placebo(for thalidomide)']

        Inclusion Criteria:

          -  Age 18-50 years old

          -  Diagnosis of patients with CD

          -  Disease in the activity: CDA Ⅰ > 150 points, endoscopic see active lesions

          -  Refractory: immunosuppressive drugs or biological agents which are used in current
             treatment is invalid and/or intolerance

        Exclusion Criteria:

          -  Fiber stenosis caused by gastrointestinal obstruction symptoms

          -  Fistula exclude anal fistula

          -  Pregnancy or lactation

          -  Period of women have fertility program during the study

          -  Treatment not foot eight weeks after last IFX

          -  Central or peripheral nerve disease

          -  Abnormal in liver and renal function

          -  Heart function failure

          -  Malignant tumor

          -  Active tuberculosis
      