['major depressive disorder']
['alks 5461']

        Inclusion Criteria:

          -  Body mass index of 18-40 kg/m2

          -  Have a diagnosis of MDD

          -  Have a current major depressive episode (MDE) lasting 8 weeks to 24 months

          -  Have been treated with an adequate dose of an approved antidepressant during the
             current MDE for at least 8 weeks

          -  Have an inadequate response to current antidepressant treatment

          -  Agree to use an approved method of birth control for the duration of the study

          -  Additional criteria may apply

        Exclusion Criteria:

          -  Currently pregnant or breastfeeding

          -  History of or current infection with Hepatitis B Virus, Hepatitis C Virus or Human
             Immunodeficiency Virus (HIV)

          -  Have experienced hallucinations, delusions, or any psychotic symptoms in the current
             MDE

          -  Have used opioid agonists (eg, codeine, oxycodone, tramadol, or morphine) or opioid
             antagonists (eg, naloxone, naltrexone) within 14 days

          -  Have received electroconvulsive therapy treatment within the last 5 years

          -  Have attempted suicide within the past 2 years

          -  Have a history of intolerance, allergy, or hypersensitivity to buprenorphine or opioid
             antagonists (eg, naltrexone, naloxone)

          -  Have had a significant blood loss or blood donation with 60 days of screening

          -  Additional criteria may apply
      