['spinal and bulbar muscular atrophy']
['bvs857', 'placebo']

        Key Inclusion Criteria:

          -  Genetic diagnosis of SBMA with symptomatic muscle weakness

          -  Able to complete 2 minute timed walk

          -  Serum IGF-1 level less than or equal to 170 ng/mL

        Key Exclusion Criteria:

          -  Medically treated diabetes mellitus or known history of hypoglycemia

          -  History of Bell's palsy

          -  Treatment with systemic steroids > 10 mg/day (or equivalent dose); androgens or
             androgen reducing agents; systemic beta agonists; or other muscle anabolic drugs
             within the previous 3 months

          -  History of cancer, other than non-melanomatous skin cancer

          -  Retinopathy

          -  Papilledema Other protocol defined inclusion/exclusion criteria may apply
      