['pulmonary disease, chronic obstructive']
['umeclidinium bromide', 'placebo']

        Inclusion Criteria:

          -  Type of subject: outpatient, Asian ancestry.

          -  Informed Consent: A signed and dated written informed consent prior to study
             participation.

          -  Age: 40 years of age or older at Screening (Visit 1).

          -  Gender: Male or female subjects are eligible to participate in the study. A female is
             eligible to enter and participate in the study if she is of: Non-child bearing
             potential (i.e. physiologically incapable of becoming pregnant, including any female
             who is post-menopausal or surgically sterile). Surgically sterile females are defined
             as those with a documented hysterectomy and/or bilateral oophorectomy or tubal
             ligation. Post-menopausal females are defined as being amenorrhoeic for greater than 1
             year with an appropriate clinical profile, e.g. age appropriate, >45 years, in the
             absence of hormone replacement therapy. However, in questionable cases, post-menopause
             status may be confirmed by analysis of a blood sample with follicle-stimulating
             hormone (FSH) >40 million international units per milliliter (MIU/ml) and estradiol
             <40 picogram (pg) /ml (<140 picomole per liter (pmol/L) as confirmatory. OR Child
             bearing potential, provided the subject has a negative pregnancy test at screening,
             and agrees to one of the following acceptable contraceptive methods used consistently
             and correctly (i.e. in accordance with the approved product label, and the
             instructions of the physician for the duration of the study - Screening to Follow-Up
             contact): Abstinence\ Oral contraceptive either combined or progestogen alone\
             Injectable progestogen\ Implants of levonorgestrel\ Estrogenic vaginal ring\
             Percutaneous contraceptive patches\ Intrauterine device (IUD) or intrauterine system
             (IUS)\ Male partner sterilization (vasectomy with documentation of azoospermia) prior
             to the female subject's entry into the study and this male is the sole partner for
             that subject\ Double barrier method condom and an occlusive cap (diaphragm or
             cervical/vault caps) with a vaginal spermicidal agent
             (foam/gel/film/cream/suppository).

          -  COPD History: An established clinical history of COPD in accordance with the
             definition by the American Thoracic Society/European Respiratory Society as follows:
             COPD is a preventable and treatable disease state characterized by airflow limitation
             that is not fully reversible. The airflow limitation is usually progressive and is
             associated with an abnormal inflammatory response of the lungs to noxious particles or
             gases, primarily caused by cigarette smoking. Although COPD affects the lungs, it also
             produces significant systemic consequences.

          -  Tobacco Use and Smoking History: Current or former cigarette smokers with a history of
             cigarette smoking of >= 10 pack-years [Number of pack years = (number of cigarettes
             per day /20) x number of years smoked (e.g. 20 cigarettes per day for 10 years, or 10
             cigarettes per day for 20 years both equal 10 pack years)]. Former smokers are defined
             as those who have stopped smoking for at least 6 months prior to Visit 1. Note: Pipe
             and/or cigar use cannot be used to calculate pack-year history. COPD patients who only
             use a pipe and/or cigar are not eligible.

          -  Severity of Disease: A pre and post-salbutamol/albuterol FEV1/FVC ratio of <0.70 and a
             pre and post-salbutamol/albuterol FEV1 of <=70% of predicted normal values calculated
             using National Health and Nutrition Examination Survey III reference equations at
             Visit 1.

          -  Dyspnea: A score of >=2 on the Modified Medical Research Council Dyspnoea Scale (mMRC)
             at Screening (Visit 1)

        Exclusion Criteria:

          -  Pregnancy: Women who are pregnant or lactating or are planning on becoming pregnant
             during the study.

          -  Asthma: A current diagnosis of asthma.

          -  Other Respiratory Disorders: Known alpha-1 antitrypsin deficiency, active lung
             infections (such as tuberculosis) and lung cancer are absolute exclusionary
             conditions. A subject, who in the opinion of the investigator has any other
             significant respiratory conditions in addition to COPD should be excluded. Examples
             may include clinically significant bronchiectasis, pulmonary hypertension, sarcoidosis
             or interstitial lung disease.

          -  Other Diseases/Abnormalities: Subjects with historical or current evidence of
             clinically significant cardiovascular, neurological, psychiatric, renal, hepatic,
             immunological, endocrine (including uncontrolled diabetes or thyroid disease) or
             haematological abnormalities that are uncontrolled and/or a previous history of cancer
             in remission for <5 years prior to Visit 1 (localized carcinoma of the skin that has
             been resected for cure is not exclusionary). Significant is defined as any disease
             that, in the opinion of the investigator, would put the safety of the subject at risk
             through participation, or which would affect the efficacy or safety analysis if the
             disease/condition exacerbated during the study.

          -  Chest X-Ray: A chest X-ray or computed tomography (CT) scan that reveals evidence of
             clinically significant abnormalities not believed to be due to the presence of COPD. A
             chest X-ray must be taken at Visit 1 if a chest X-ray or CT scan is not available
             within 6 months prior to Visit 1.

          -  Contraindications: A history of allergy or hypersensitivity to any
             anticholinergic/muscarinic receptor antagonist, beta2-agonist, lactose/milk protein or
             magnesium stearate or a medical condition such as of narrow-angle glaucoma, prostatic
             hypertrophy or bladder neck obstruction that, in the opinion of the study physician
             contraindicates study participation or use of an inhaled anticholinergic.

          -  Hospitalization: Hospitalization for COPD or pneumonia within 12 weeks prior to Visit
             1.

          -  Lung Resection: Subjects with lung volume reduction surgery within the 12 months prior
             to Screening (Visit 1).

          -  12-Lead electrocardiogram (ECG): An abnormal and significant ECG finding from the
             12-lead ECG conducted at Visit 1, including the presence of a paced rhythm on a
             12-lead ECG which causes the underlying rhythm and ECG to be obscured. Investigators
             will be provided with ECG reviews conducted by a centralized independent cardiologist
             to assist in evaluation of subject eligibility. Specific ECG findings that precluded
             subject eligibility are as listed. An ECG finding that would preclude a subject from
             entering the trial is defined as a 12-lead tracing that is interpreted as, but not
             limited to, any of the following: Sinus tachycardia ≥120 bpm*Note: sinus tachycardia
             ≥120bpm should be confirmed by two additional readings at least 5 minutes apart. Sinus
             bradycardia <45bpm*Note: Sinus bradycardia <45bpm should be confirmed by two
             additional readings at least 5 minutes apart.Multifocal atrial
             tachycardia.Supraventricular tachycardia (>100bpm).Atrial fibrillation with rapid
             ventricular response (rate >120bpm). Atrial flutter with rapid ventricular response
             (rate >120bpm). Ventricular tachycardias (non sustained, sustained, polymorphic, or
             monomorphic). Ventricular flutter. Ventricular fibrillation. Torsades de Pointes.
             Evidence of Mobitz type II second degree or third degree atrioventricular (AV) block.
             AV dissociation. Trifascicular Block. For subjects with QRS duration <120 ms: QTc(F)
             ≥450msec or an ECG that is unsuitable for QT measurements (e.g., poor defined
             termination of the T wave). For subjects with QRS duration>120: QTc(F) ≥480msec or an
             ECG that is unsuitable for QT measurements (e.g., poor defined termination of the T
             wave). Myocardial infarction (acute or recent) * Note: Evidence of an old (resolved)
             myocardial infarction is not exclusionary. The study investigator will determine the
             medical significance of any ECG abnormalities not listed above.

          -  Screening Labs: Significantly abnormal findings from clinical chemistry and
             haematology tests at Visit 1.

          -  Medications Prior to Spirometry: Unable to withhold albuterol/salbutamol for the 4
             hour period required prior to spirometry testing at each study visit.

          -  Medications Prior to Screening: Use of the following medications according to the
             following defined time intervals prior to Visit 1 is presented as Medication with Time
             Interval Prior to Visit 1: Depot corticosteroids (12 weeks); Systemic, oral,
             parenteral (intra-articular) corticosteroids (4 weeks); Antibiotics (for lower
             respiratory tract infection) (4 weeks); inhaled corticosteroid/ long-acting beta
             agonist (ICS/LABA) combination products if ICS/LABA therapy is discontinued completely
             (30 days); Use of ICS at a dose >1000mcg/day of fluticasone propionate or equivalent
             (30 days); Initiation or discontinuation of ICS use (30 days); Phosphodiesterase 4
             (PDE4) inhibitors (roflumilast) (14 days); Long-acting anticholinergics
             (e.g.,tiotropium and aclidinium, glycopyronium) (7 days); Theophyllines (12 hours
             stable dose of theophylline alone is allowed during the study but must be withheld 12
             hours prior to each study visit); Oral leukotriene inhibitors (zafirlukast,
             montelukast, zileuton) (48 hours); Oral beta2-agonists (Long- acting 48 hours, Short
             -acting 12 hours); Olodaterol and Indacaterol (inhaled long-acting beta2-agonist) (14
             days); Salmeterol, formoterol, (inhaled long-acting beta2-agonist) (48 hours); LABA/
             ICS combination products only if discontinuing LABA therapy and switching to ICS
             monotherapy (48 hours for LABA component); Inhaled sodium cromoglycate or nedocromil
             sodium (24 hours); Inhaled short acting beta2-agonists (4 hours); Inhaled short-acting
             anticholinergics (e.g. ipratropium bromide) (4 hours, stable dose of ipratropium alone
             is allowed during the study, provided that the subject is on a stable dose regimen
             from Screening [Visit 1 and remains so throughout the study] but must be withheld 4
             hours prior to each study visit); Inhaled short-acting anticholinergic/short-acting
             beta2-agonist combination products (4 hours); Any other investigational drug (30 days
             or 5 half lives, whichever is longer). Note: Further details related to allowable
             dosage of above listed medications will be explained by the Investigator)
      