
    no subjects were enrolled.
  
['scleroderma', 'systemic sclerosis']
['divalproex sodium']

        Inclusion Criteria:

          -  18 years of age or older

          -  Diagnosis of scleroderma as defined by the American College of Rheumatology (ACR)

          -  Presence of at least one digital manifestation occurring within the past 6 months,
             i.e. digital swelling/edema, digital ulcer, calcinosis cutis, restricted digital range
             of motion.

          -  Females of childbearing potential must take an oral contraceptive pill or use an
             equivalent birth control method during the study.

        Exclusion Criteria:

          -  Age <18 years old

          -  Ongoing use of high dose steroids (>10 mg/day) or unstable steroid dose in past 4
             weeks.

          -  An investigational drug or disease-modifying agent has been started within the past 6
             months, including but not limited to systemic corticosteroids, methotrexate,
             cyclosporine, azathioprine, cyclophosphamide, bosentan, mycophenolate mofetil,
             thalidomide, colchicine.

          -  Patient taking a medication with a significant drug-drug interaction with divalproex
             sodium, e.g. clomipramine and lamotrigine.

          -  Patient has another connective tissue disease or other condition that could affect
             rest pain and hand function, e.g. systemic lupus erythematosus, rheumatoid arthritis,
             or osteoarthritis.

          -  Patient has uncontrolled diabetes, chronic kidney disease, chronic hepatitis.

          -  Any of the following laboratory abnormalities at baseline: anemia (Hb < 8.5 gm/dL),
             thrombocytopenia with platelets <100,000, INR > 1.3 or known bleeding disorder,
             estimated GFR < 60 mL/min/1.73m2 or serum creatinine > 2.0 mg/dL, hyperbilirubinemia
             or elevation of AST or ALT

          -  Pregnancy or breast-feeding.

          -  History of severe depression (i.e. depression requiring medical treatment by a
             psychiatrist), suicidal ideation, epilepsy, bipolar disorder, or schizophrenia.
      