['rectal carcinoma']
['capecitabine']

        Inclusion Criteria:

          -  Biopsy-proven newly diagnosed primary rectal adenocarcinoma

          -  Locally advanced tumor fulfilling at least one of the following criteria on pelvic
             MRI:

               -  T ≥ 3 or

               -  N ≥ 1

               -  Positive mesorectal fascia (MRF), i.e. tumor or lymph node one mm or less from
                  the mesorectal fascia

               -  Tumor located od 0 - 15 cm above anocutaneous junction or below peritoneum

          -  Age 18 years and more

          -  Signed informed consent

          -  WHO Performance Status 0-2

          -  Patients is considered to be mentally and physically ft for chemotherapy as judged by
             oncologist

          -  Adequate hematological, hepatic and renal function (WBC ≥ 3.0 x 109/L, neu ≥ 1.5 x
             109/L, platelet count ≥ 100 x 109/L, renal clearance ≥ 50 ml/min, bilirubin ≤ 3x
             normal value, aspartate transaminase/alanine transaminase (AST/ALT) ≤ 2,5x normal
             value)

        Exclusion Criteria:

          -  T4 inoperable tumor - extensive growth into cranial part of the sacrum (above S3) or
             the lumbosacral nerve roots

          -  Metastatic or recurrent rectal cancer

          -  Other co-existing malignancy or malignancy within the past 5 years, with the exception
             of adequately treated in situ carcinoma of the cervix or basal cell carcinoma of the
             skin

          -  Chronic bowel inflammatory disease

          -  Pregnant or lactating patient

          -  Significant heart disease (uncontrolled hypertension despite of medication (> 150/100
             mmHg), New York Heart Association (NYHA) class III or IV heart disease,unstable angina
             or myocardial infarction within the past 1 year prior the study entry, history of
             significant ventricular arrhythmia requiring treatment)

          -  Inability to consciously sign the consent form due to physical or psychological
             disabilities
      