
    low recruitment
  
['chronic graft versus host disease']
['ponesimod']

        Inclusion Criteria:

          -  Signed informed consent

          -  Symptomatic moderate or severe chronic GVHD patients in need of a change of systemic
             immunosuppressant (IS) therapy

          -  Women of child bearing potential must have a negative pregnancy test and use reliable
             methods of contraception

        Exclusion Criteria:

          -  Clinically significant medical conditions including active or uncontrolled infections,
             new or recurrent malignancy, serious cardiac, pulmonary, or renal disease, and
             uncontrolled diabetes.

          -  Karnofsky Performance Score < 60.

          -  Immunosuppressant therapies other than allowed background therapy

          -  Anti-arrhythmic and heart rate lowering drugs.

          -  Any other circumstances or conditions, which, in the opinion of the investigator, may
             affect full participation in the study or compliance with the protocol
      