
    accrual rate remaining too low
  
['hilar cholangiocarcinoma']
['photodynamic therapy-photofrin', 'chemotherapy regimen']

        Inclusion Criteria:

          -  Males or females aged 18 or older

          -  Diagnosed with radiologically and biopsy or cytology confirmed inoperable perihilar
             cholangiocarcinoma Bismuth Tumor Stage III/IV

          -  Non-menopausal or non-sterile female subjects of childbearing potential must have a
             negative serum beta-HCG and use a medically acceptable form of birth control

          -  Able to sign an informed consent

        Exclusion Criteria:

          -  Diagnostic of cholangiocarcinoma made more than 45 days prior to randomization

          -  Cholangiocarcinoma with extra-hepatic metastasis or concurrent non-solid malignancy

          -  Presence or history of other neoplasms (treated during the last five years prior to
             study entry) other than carcinoma in situ of the cervix or basal carcinoma of the skin

          -  Previously received photodynamic therapy for cholangiocarcinoma

          -  Previously undergone surgical resection of the cholangiocarcinoma

          -  Previously undergone chemotherapy, brachytherapy, or radiotherapy prior to entering
             the study

          -  Previously undergone metal stent insertion

          -  Porphyria or hypersensitivity to porphyrins (constituents of porfimer sodium),
             gemcitabine, cisplatin or other platinum-containing compounds

          -  Presence of infection other than the infection of the bile duct (cholangitis)

          -  Acute or chronic medical or psychological illnesses that prevent endoscopy procedures

          -  Abnormal blood test results

          -  Severe impairment of your kidney or liver function

          -  Decompensated cirrhosis

          -  Pregnant or intend to become pregnant, breastfeeding or intend to breast-feed during
             this study

          -  Participated in another drug study within 90 days before this one

          -  Unable or unwilling to complete the follow-up evaluations required for the study
      