
    deficient inclusion
  
['heart failure']
['prophylactic treatment with wilfactin']

        Inclusion Criteria:

          -  Adult patients > 18 years who need a CF-LVAD due to advanced heart failure.

          -  Functional defects of VWF measured between day 2 and day 4 after implantation (either
             PFA-ADP closure time >180 sec and or VWF:Act/VWF:Ag≤ 0.7)

          -  Informed consent of the patient or support person in case of disability at baseline
             (patient intubated and ventilated)

        Exclusion Criteria:

          -  Treatment with Wilfactin® within the last seven days

          -  Previous adverse reaction to Wilfactin®

          -  Absence of functional defects of VWF measured between day 2 and day 4 after
             implantation (either PFA-ADP closure time >250 sec and or VWF:Act/VWF:Ag<0.7)

          -  Patient with a known thrombophilia

          -  Patient with a known severe bleeding disorder

          -  Patient refusal or environment

          -  Minor patients

          -  Pregnant women
      