['diabetes mellitus, type 2', 'hypertension']
['matching placebo', 'iw-1973']

        Inclusion Criteria:

          -  Patient is ambulatory male or female

          -  Patient's body mass index score is >20 and <40 kg/m2 at the Screening Visit

          -  Women of childbearing potential must have a negative pregnancy test at the time of
             check-in and must agree to use double-barrier contraception throughout the duration of
             the study

          -  Patient's health is stable with no clinically significant findings on a physical
             examination

          -  Patient has type 2 (ie adult onset) diabetes mellitus diagnosed by a physician or
             nurse practitioner > 6 months before the Screening Visit, and an entry HbA1c that does
             not mandate prompt intervention for improved control

          -  Patient has hypertension diagnosed by a physician or nurse practitioner > 6 months
             before the Screening Visit and BP within the protocol's acceptable range

          -  Patients must be on a stable regimen for glycemic control, and a stable regimen for
             hypertension control that includes an angiotensin converting enzyme inhibitor (ACEi)
             or angiotensin receptor blocker (ARB)

          -  Patient has abnormal endothelial function measured by the EndoPAT

          -  Other inclusion criteria per protocol

        Exclusion Criteria:

          -  Patient has a clinically significant active or unstable medical condition that, in the
             opinion of the Investigator, would preclude trial participation

          -  Patient is on medication(s) that when co-administered with a soluble guanylate cyclase
             (sGC) stimulator, could increase the risk of hypotension

          -  Patient has evidence of severe or active end-organ damage attributable to diabetes

          -  Patient has severe renal insufficiency, has undergone renal transplantation, or has
             planned renal transplantation

          -  Other exclusion criteria per protocol
      