
    poor accrual
  
['ddp', 'head and neck cancer', 'adverse effect']
['trans-tympanic injection of a sodium thiosulfate gel']

        Inclusion Criteria:

          -  Patients with newly diagnosed locally advanced (stage III or IV) squamous cell
             carcinoma of the mouth, oropharynx, hypopharynx, or larynx scheduled to be treated
             with concomitant chemoradiation including Cisplatin100 mg/m2 3 times

          -  Normal otoscopic findings and symmetrical hearing

        Exclusion Criteria:

          -  Karnofsky below 70
      