['essential hypertension']
['cs-3150', 'eplerenone']

        Inclusion Criteria:

          -  Male and female subjects aged 20 years or older at informed consent

          -  Subjects with essential hypertension satisfying the following blood pressure criteria;

               -  Sitting SBP: ≥ 140 mmHg and < 180 mmHg

               -  Sitting DBP: ≥ 90 mmHg and < 110 mmHg

               -  Mean 24 hr BP: SBP ≥ 130 and DBP ≥ 80 mmHg

        Exclusion Criteria:

          -  Secondary hypertension or malignant hypertension

          -  Diabetic nephropathy or diabetes mellitus with albuminuria

          -  Serum potassium level < 3.5 or ≥ 5.1 mEq/L

          -  Reversed day-night life cycle including overnight workers

          -  eGFR < 60 mL/min/1.73 m^2
      