['colorectal cancer']
['acetylsalicylic acid']

        Inclusion Criteria:

          1. Men and women, aged ≥ 18 and ≤ 69.

          2. Patients should have an indication for screening colonoscopy

               1. First degree relative of patient with CRC.

               2. Personal history of adenomas.

               3. People older than 50 and FOBT positive

          3. Routine hematological and biochemical parameters within the normal range.

        Exclusion Criteria:

          1. Allergy to ASA or other NSAIDs.

          2. Previous use of ASA, NSAIDS, antiplatelet agents, corticosteroids or misoprostol in
             the previous 15 days and/or anticipated need for these drugs during the study period.

          3. Peptic ulcer history or any other gastrointestinal disease that could be considered a
             contraindication for ASA use without the concomitant use of a proton-pump inhibitor.

          4. Subjects with coagulation disorder or serious comorbid condition.

          5. Malignancies, excluding CRC, diagnosed in the previous 5 years

          6. Cigarette smoking, history of drug or alcohol abuse

          7. Pregnant women or breast feeding
      