['metastatic melanoma']
['cyclophosphamide', 'fludarabine', 'interleukin-2', 'peginterferon alfa-2b']

        Inclusion Criteria:

        Histologically confirmed unresectable stage III or stage IV metastatic melanoma Metastasis
        available for surgical resection (about 2 cm3) and residual measurable disease after
        resection

        ECOG performance status 0-1

        Life expectancy ≥ 3 months

        No significant toxicity from prior treatments

        Adequate renal, hepatic and hematologic function

        Women of childbearing potential (WOCBP) and men in a sexual relationship with a WOCBP must
        be using an effective method of contraception during treatment and for at least 6 months
        after completion af treatment.

        Able to comprehend the information given and willing to sign informed consent

        -

        Exclusion Criteria:

        Other Malignancies, unless followed for ≥ 5 years with no sign of disease, except squamous
        cell carcinoma or adequately treated carcinoma in situ colli uteri.

        Cerebral metastasis. Patients with previously treated CNS metastases can participate if CNS
        metastases are surgically removed or treated with stereotactic radiosurgery and stable ≥ 28
        days after treatment measured by MRI. Patients with asymptomatic, stable and untreated CNS
        metastasis can in be included according to investigators and sponsors decision.

        Patients with ocular melanoma

        Severe allergies, history of anaphylaxis or known allergies to the administered drugs.

        Serious medical or psychiatric comorbidity

        Creatinine clearance < 70 ml/min

        Acute or chronic infection with e.g. HIV, hepatitis, tuberculosis

        Severe and active autoimmune disease

        Pregnant and nursing women

        Need for immunosuppressive treatment, e.g. corticosteroids or methotrexate

        Concomitant treatment with other experimental drugs

        Patients with uncontrolled hypercalcemia

        Less than four weeks since prior systemic antineoplastic treatment at the time of
        treatment.

        -
      