['esophageal cancer']
['nab-paclitaxel group']

        Inclusion Criteria:

          1. inoperable locally advanced histologically confirmed esophageal cancer
             (T3N0M0-TxNxM1a（AJCC 2002)

          2. ECOG performance status scale 0-1

          3. at least 1 measurable target lesions

          4. white blood count ≥ 3,500/mm3, absolute neutrophil count ≥ 1,500/mm3, platelet count ≥
             100,000/mm3, hemoglobin count ≥ 90 g/dL, serum bilirubin level < 1.5 of the upper
             limit of normal (ULN) for the institution, aspartate aminotransferase, alanine
             aminotransferase and alkaline phosphatase ≤ 2.5 ULN, serum albumin ≥ 30g/L, serum
             creatinine ≤ 1.5 ULN; and

          5. normal cardiac function with no severe heart disease.

        Exclusion Criteria:

          1. history of esophagectomy

          2. pregnancy or breast feeding

          3. past history of other cancers except for cured non-melanoma skin cancer or cervical
             cancer;

          4. concomitant treatment with other anticancer drugs.
      