
    sponsor ceased sponsorship and terminated the research citing slow accrual of subjects in this
    clinical trial.
  
['dry eye']
['dnase', 'vehicle']

        Inclusion Criteria:

          -  Aged 18 years or older.

          -  Capable of giving informed consent and does provide informed consent.

          -  Documented Dry Eye Disease for at least 6 months.

          -  Schirmer I <10

          -  Corneal/ conjunctival (Rose Bengal) staining ≥1

          -  Ocular symptoms must be considered as annoying or activity limiting (OSDI ≥13; mild).

          -  Women must be post-menopausal ≥ 1 year, or surgically sterilized. If not, a negative
             urine pregnancy test is required within 14 days of receiving her first dose of test
             medication (placebo/ study drug) along with definite evidence of contraceptive use
             during the duration of the study.

        Exclusion Criteria:

          -  Allergic to Deoxyribonuclease eye drops or any similar products, or excipients of
             Deoxyribonuclease eye drops 0.1%.

          -  Receiving or have received within 30 days any experimental systemic medication.

          -  Active ocular infection or ocular allergies.

          -  Any history of eyelid surgery or ocular surgery within the past 3 months.

          -  Corneal epithelial defect larger than 1 mm2 in either eye.

          -  The use of topical cyclosporine or corticosteroids within 2 weeks of enrollment

          -  Have active drug/alcohol dependence or abuse history
      