["alzheimer's disease", 'mild cognitive impairment']
['vx-745']

        Inclusion Criteria:

          -  Willing and able to provide informed consent

          -  Diagnosis of mild cognitive impairment (MCI) due to probable AD or of mild AD

          -  MMSE range: 20 to 28

          -  Evidence of amyloid pathology by amyloid PET scan

          -  Participants may be taking medications for AD, provided that the dose of these
             medications has been stable for >3 months

          -  Proficiency in Dutch and adequate visual and auditory abilities to be able to perform
             all aspects of the cognitive and functional tests

          -  Adequate visual and auditory abilities to perform all aspects of the cognitive and
             functional assessments.

        Exclusion Criteria:

          -  Evidence of neurodegenerative disease other than AD

          -  Inability for any reason to undergo PET and fMRI scans (including notably: history of
             allergic reaction of any severity to 11C-PiB injection; pacemaker, vascular stent or
             stent graft)

          -  Psychiatric disorder that would compromise ability to comply with study requirements

          -  Significant cardiovascular, pulmonary, renal, liver, infectious disease, immune
             disorder or metabolic/endocrine disorders or other disease that would preclude
             treatment with p38 MAP kinase inhibitor and/or assessment of drug safety and efficacy

          -  Recent (<90 days) changes to AD medications prescribed for cognitive reasons or with
             the potential to impact cognition

          -  Participation in a study of an investigational drug less than 6 months or 5 half-lives
             of the investigational drug, whichever is longer, before enrollment in the study

          -  Male subjects with female partner of child-bearing potential who are unwilling or
             unable to adhere to contraception requirements

          -  Female subjects who have not reached menopause or have not had a hysterectomy or
             bilateral oophorectomy/salpingoophorectomy

          -  Positive urine or serum pregnancy test or plans desires to become pregnant during the
             course of the trial

          -  Any factor deemed by the investigator to be likely to interfere with study conduction
      