
    interim assessment: lack of efficacy
  
['osteoarthritis, knee']
['ly2951742', 'celecoxib']

        Inclusion Criteria:

          -  Have osteoarthritis (OA) of the knee joint based on American College of Rheumatology
             (ACR) criteria and confirmed with X-rays and ACR functional class of I to III

          -  Have been on stable dose of prescription Nonsteroidal Anti-Inflammatory Drugs
             (NSAIDS), celecoxib, tramadol, or acetaminophen of at least 2000 mg per day for at
             least 20 days in the past month

          -  Willing to stop all analgesics for OA pain during the study

          -  Experienced pain while walking in the target knee of 50-90 mm inclusive on 0-100
             Visual Analog Scale (VAS) with an increase in pain while walking of at least 10 mm
             following washout of current Osteoarthritis pain medications at screening

        Exclusion Criteria:

          -  Allergic to LY2951742, celecoxib, other NSAIDS, including aspirin, and similar drugs

          -  Arthritis of the knee from other causes

          -  Uncontrolled hypertension

          -  Have OA pain that requires treatment with potent opioids, systemic corticosteroids,
             intra-articular injections, duloxetine, or venlafaxine

          -  Moderate to severe renal impairment

          -  Pregnant or lactating
      