['peripheral artery disease', 'type 2 diabetes']
['aspirin', 'ticagrelor', 'aspirin placebo', 'ticagrelor placebo']

        Inclusion Criteria:

          -  Female or male aged ≥ 35 years

          -  Type 2 diabetes mellitus

          -  Symptomatic PAD

          -  Ankle-brachial index ≤ 0.85 or calcified blood vessels with toe-brachial index ≤ 0.6
             and/or abnormal post-exercise ankle-brachial index

          -  Prior surgical or percutaneous intervention of the peripheral arteries ≥12 months
             previously with a residual stenoses of ≥50% in a non-dilated artery.

        Exclusion Criteria:

          -  Subject is pregnant or breast-feeding

          -  Planned revascularization or amputation

          -  Known bleeding disorder

          -  History of intracranial hemorrhag3

          -  Considered at risk of hemorrhagic events

          -  Hypersensitivity or allergic reactions to aspirin

          -  Concomitant use of anticoagulants such as warfarin, dabigatran, factor Xa inhibitors
             or antiplatelet drugs such as clopidogrel, dipyridamole and sulfapyridine

          -  Subject has a condition or circumstance which would prevent them from adhering to
             treatment regimens

          -  Subject has active infection

          -  Subject has an anemia

          -  Subject has given blood or received a blood transfusion at any point during the study

          -  Subject has polycythemia vera or any hyperviscosity syndrome

          -  Subjects with Waldenstrom's macroglobulinemia who have an increased risk of
             hyperviscosity syndrome

          -  Subject has history of severe liver disease, obstructive liver disease such as primary
             biliary cirrhosis or end-stage renal disease (eGFR <30 mL/min/m2)

          -  Family members or employees of the investigator or study centers involved in the study

          -  Subject has poor diabetes or hypertension control (systolic blood pressure ≥ 180 mmHg
             or diastolic blood pressure ≥ 100 mmHg)
      