['prostatic neoplasms']
['radium-223 dichloride (xofigo, bay88-8223)']

        Inclusion Criteria:

          -  Histologically or cytologically confirmed adenocarcinoma of the prostate

          -  Castration-resistant disease defined as:

               -  Serum testosterone level: ≤ 50 ng/dL (1.7 nmol/L)

               -  Bilateral orchiectomy or maintenance on androgen ablation therapy with
                  luteinizing-hormone-releasing hormone (LHRH) agonist or antagonist, or
                  polyestradiol phosphate

               -  Serum PSA (Prostate specific antigen) progression defined as 2 subsequent
                  increases in PSA over a previous reference value (a minimum of 2 ng/mL [μg/L]) OR

               -  Radiographic evidence of disease progression in bone (according to Prostate
                  Cancer Clinical Trials Working Group 2 [PCWG2] criteria) with or without PSA
                  progression

          -  Eastern Cooperative Oncology Group performance status (ECOG PS) 0 to 2. In case of
             ECOG PS 2, the PS has to be due to metastatic prostate cancer to the bone.

          -  Two or more skeletal metastases (≥ 2 hot spots) on bone scintigraphy within 8 weeks of
             randomization

        Exclusion Criteria:

          -  History of visceral metastasis, or visceral metastases

          -  Lymphadenopathy with lymph nodes exceeding 3 cm in short axis diameter

          -  Central nervous system (CNS) metastases

          -  Treatment with cytotoxic chemotherapy for prostate cancer within the previous 4 weeks
             prior to randomization, or planned treatment with cytotoxic chemotherapy agents for
             prostate cancer during the treatment period or follow-up

          -  Chronic conditions associated with non-malignant abnormal bone growth (e.g. confirmed
             Paget's disease of bone)

          -  Prior treatment with radium-223 dichloride

          -  Prior systemic radiotherapy and hemibody external radiotherapy
      