['self efficacy', 'adverse drug event', 'carcinoma, renal cell']
['pazopanib']

        Inclusion Criteria:

          1. Written informed consent

          2. Diagnosis of renal cell carcinoma with clear-cell component histology.

          3. Locally advanced/metastatic renal cell carcinoma

          4. Measurable lesion (RECIST 1.1) on physical exam or as CT/MRI

          5. No prior systemic therapy for advanced/metastatic RCC

          6. Karnofsky performance scale >=70

          7. Age >=18 years

          8. A female is eligible to enter and participate in this study if she is of:
             non-childbearing/agrees to use adequate contraception

          9. A male with female partner of childbearing potential must have vasectomy/agree to use
             effective contraception from two weeks prior to administration of the 1st dose of
             study treatment for a period of time after the last dose of study treatment

         10. Adequate organ function

         11. Able to swallow and retain orally administered medication and must not have clinically
             significant GIT abnormalities that may alter absorption

         12. The date of disease progression must be within six months of stopping sunitinib or
             during treatment with sunitinib

         13. Measurable lesion at pazopanib baseline as per the RECIST 1.1 criteria

        Exclusion Criteria:

          1. Pregnant/lactating

          2. History of another malignancy (unless have been disease-free for 3 years)

          3. History or clinical evidence of Central nervous system metastases (unless have
             previously-treated CNS metastases and who meet both of the following criteria: a) are
             asymptomatic and b) have no requirement for steroids or enzyme-inducing
             anticonvulsants in prior 6 month time interval.

          4. Clinically significant gastrointestinal abnormalities including, but not limited to:
             malabsorption syndrome, major resection of the stomach or small bowel that could
             affect the absorption of study drug, active peptic ulcer disease, known intraluminal
             metastatic lesion/s with suspected bleeding, Inflammatory bowel disease, ulcerative
             colitis, or other gastrointestinal conditions with increased risk of perforation,
             history of abdominal fistula, gastrointestinal perforation, or intra abdominal abscess

          5. Moderate to severe hepatic impairment (Child-Pugh Class C)

          6. Any serious and/or unstable pre-existing medical, psychiatric, or other conditions
             that could interfere with patient's safety, obtaining informed consent or compliance
             to the study.

          7. Subjects receiving chronic treatment with corticosteroids/other immunosuppressive
             agents

          8. Subjects with a known history of HIV seropositivity

          9. Subjects with active bleeding, bleeding diathesis or on oral anti-vitamin K medication
             (except low dose coumadin)

         10. Presence of any severe or uncontrolled medical conditions/infection.

         11. Currently receiving chemotherapy, immunotherapy or radiotherapy

         12. Corrected QT interval (QTc) > 480 milliseconds

         13. History of any one or more of the following cardiovascular conditions within the past
             12 months: cardiac angioplasty or stenting, myocardial infarction, unstable angina,
             coronary artery by-pass graft surgery, symptomatic peripheral vascular disease, Class
             III or IV congestive heart failure, as defined by the New York Heart Association

         14. Poorly controlled hypertension (defined as systolic blood pressure of >=140mmHg or
             diastolic blood pressure of >=90mmHg).

         15. History of cerebrovascular accident including transient ischemic attack, pulmonary
             embolism or untreated deep venous thrombosis (DVT) within the past 6 months (unless
             recent DVT have been treated with therapeutic anti-coagulating agents for at least 6
             weeks)

         16. Major surgery or trauma within 28 days prior to first dose of study drug and/or
             presence of any non-healing wound, fracture, or ulcer.

         17. Evidence of active bleeding or bleeding susceptibility.

         18. Known endobronchial lesion and/or lesions infiltrating major pulmonary vessels that
             increase the risk of pulmonary hemorrage
      