['pulmonary disease, chronic obstructive']
['bct197', 'placebo']

        Inclusion Criteria:

          -  Male and female adults

          -  Presence of an active exacerbation of the ongoing COPD requiring hospitalization for
             treatment

          -  Subjects with a documented diagnosis of COPD C or D

          -  Current smokers or ex-smokers

          -  A documented history of at least one moderate or severe COPD exacerbation in the 12
             months preceding the Screening Visit that required antibiotics and/or systemic
             corticosteroid.

          -  Current regular treatment for COPD (for at least 2 months prior to the Screening
             Visit.

        Exclusion Criteria:

          -  Age less than 40 years old

          -  Current diagnosis of asthma

          -  Subjects who have already completed treatment for the current exacerbation of COPD

          -  Subjects currently requiring intensive care unit (ICU) and/or mechanical ventilation

          -  Received a course of PDE4, p38 or PDE3/4 inhibitors within their respective defined
             washout periods.
      