['breast cancer', 'invasive breast cancer']
['chloroquine', 'placebo']

        Inclusion Criteria:

          -  newly diagnosed histologically confirmed primary invasive breast cancer who is
             currently not undergoing any treatment while awaiting surgery in the next 2-6 weeks

          -  tumour ≥ 1.5 cm by palpation or imaging

          -  ECOG performance status 0-2

          -  written informed consent for the study

        Exclusion Criteria:

          -  Known Metastatic breast cancer

          -  history of pre-existing known retinal or ocular pathology patient has only one
             functioning eye

          -  abnormal hepatic function (serum AST or ALT >3x upper limit of normal)

          -  currently on CQ or HCQ or has been on the drug within the past 3 months for other
             conditions

          -  known history of psoriasis

          -  known history of epilepsy or seizures

          -  electrocardiogram showing QT prolongation based on QTc interval >450 ms

          -  inability to comply with a study protocol (abuse of alcohol, drugs or psychotic
             states)

          -  current known pregnancy or actively nursing

          -  allergic reactions to quinolones or CQ

          -  inability to consent.
      