['staphylococcal infection']
['mupirocin calcium', 'mupirocin calcium']

        Inclusion Criteria:

        1. Currently admitted to a NICU or ICU at a participating site 2. Chronological age less
        than 24 months 3. Evidence of colonization with SA (MRSA or MSSA) based on a positive nasal
        surveillance culture. Randomization must occur within 7 days (168 hours) of when the site's
        laboratory reports the first SA positive nasal surveillance swab 4. The attending
        neonatologist/ intensivist anticipates that the infant will remain in the ICU for a minimum
        of 14 days after enrollment 5. Parent or legal guardian agrees that the infant will not
        participate in a research trial involving the administration of an investigational drug for
        14 days following enrollment

        Exclusion Criteria:

        1. Receipt of an investigational drug as part of a research trial within the past 14 days
        2. Previously enrolled and participated in this trial 3. Has an active or previous SA
        infection 4. Currently receiving topical or intranasal mupirocin 5. Has a rash in an area
        to which mupirocin will be directly applied 6. Has any of the following congenital
        abnormalities: --A congenital skin disorder (i.e. - epidermolysis bullosa, icthyosis) --An
        opened neural tube defect --Confirmed or suspected choanal atresia --Any of the following
        abdominal wall defects: wound dehiscence, gastroschisis, open abdominal wound (small
        abdominal wall defects such as ostomy sites or peritoneal drain sites are not exclusionary)
        7. Is nasally intubated 8. Known hypersensitivity to the trial product or its constituents
        9. Known or suspected immune deficiency. Infants born to HIV-seropositive mothers with the
        following risk factors for intrapartum transmission will not be eligible to participate:
        --Mother's most recent viral load within the past 3 months was > 1,000 copies/ml or
        --Mother's viral load is not known or has has not been measured in the past 3 months. 10.
        Any other condition(s) that in the opinion of the investigator would jeopardize the safety
        or rights of a participant or would render the participant unable to comply with the
        protocol
      