
    difficulties with inclusion
  
['multiple sclerosis']
['cholecalciferol']

        Inclusion Criteria:

          -  Female

          -  Relapsing Remitting MS

          -  At start of study > 6 weeks in clinical remission of disease

          -  Age > 18 years.

          -  Premenopausal

          -  Treated with either no immune-modulating treatment, or the currently registered MS
             modulating treatments: Interferon beta 1a (Rebif®), Interferon Beta 1b (Betaferon® or
             Avonex®), Glatiramer Acetate (Copaxone®), dimethylfumarate (Tecfidera®), teriflunomide
             (Aubagio®)) or fingolimod (Gilenya®).

        Exclusion Criteria:

          -  Any contraindication to vitamin D according to Summary of Product Characteristics:
             Hypercalcaemia, hypervitaminosis D, nephrolithiasis, diseases or conditions resulting
             in hypercalcaemia and/or hypercalciuria (incl. primary hyperparathyroidism), severe
             renal impairment .

          -  Use of dexamethasone or other systemic glucocorticosteroids <2 months prior to first
             study visit

          -  Supplementation of >=1000 IU/d (25µg) vitamin D2 or D3

          -  Medical history of disturbed vitamin D/ calcium metabolism other than low intake

          -  Present clinical (major)depression

          -  Present treatment with anti-depressants, benzodiazepines, or neuroleptics.

          -  Treatment with high-dose dexamethasone for MS exacerbation during study.

          -  Pregnancy or the intention to become pregnant during the study period.
      