['hepatitis b', 'hepatitis, viral']
['sb 9200', 'placebo', 'tenofovir']

        Inclusion Criteria:

          1. Documented evidence of chronic HBV infection (eg, HBsAg positive for at least 6 months
             or HBV DNA positive for at least 6 months). In the absence of documented evidence of
             HBsAg or HBV DNA, the subject must be HBsAg positive, and anti-HBc (IgM) negative at
             Screening.

          2. Not on any antiviral medications for at least 6 months. If a subject is HBeAg
             negative, they will be eligible if they have not received antiviral medications for at
             least 3 months. Antiviral medications include lamivudine, telbivudine, adefovir,
             tenofovir, entecavir, IFN therapies of any type, and all other medications with
             potential antiviral activity.

          3. HBV DNA > 2000 IU/mL for HBeAg-negative subjects and > 20000 IU/mL for HBeAg-positive
             subjects at Screening

          4. ALT > ULN, but < 5 x the ULN and ≤ 200 U/L

          5. Ultrasound, computed tomography (CT) scan, or magnetic resonance imaging (MRI) within
             3 months of randomization date with no evidence of hepatocellular carcinoma

          6. Must be willing and able to comply with all study requirements

          7. Negative urine or serum pregnancy test (for women of childbearing potential [WOCBP])
             documented within the 24-hour period prior to the first dose of test drug. If the
             urine pregnancy test is positive, a follow-up serum test is required for confirmation.
             Additionally, all fertile males with partners of childbearing age and females must be
             using reliable contraception during the study and for 3 months after treatment
             completion. All fertile males must also refrain from sperm donation while on IP and
             for 3 months after completion of IP.

          8. Must have the ability to understand and sign a written ICF; consent must be obtained
             prior to initiation of study procedures

        Inclusion Criteria for Extension Period:

        Subjects who meet all of the following inclusion criteria may be eligible to be enrolled
        into the Extension Period:

          1. Signed informed consent form

          2. Subject was randomized in Part A or Part B

        Exclusion Criteria:

        Subjects who meet any of the following exclusion criteria are not to be enrolled in this
        study:

          1. Any prior liver biopsy evidence of metavir F3 or F4 disease

          2. Any history of decompensation of liver disease including history of ascites,
             encephalopathy, or varices

          3. Evidence of cirrhosis as defined by Fibroscan at the Screening Visit of ≥ 8
             kilopascals (kPa) or both a Fibrotest ≥ 0.65 and AST:platelet ratio index (APRI) ≥ 1.0
             (subjects will not be excluded if only 1 of the Fibrotest or APRI result is higher
             than allowed) or have had evidence of Metavir F3-F4 on liver biopsy at any time.

          4. Laboratory parameters not within defined thresholds: white blood cells (WBC) < 4000
             cells/µL, (SI unit < 4.0 × 109/L), hemoglobin (HgB) < 12 g/dL (SI unit < 120 g/L) for
             females, < 13 g/dL (SI unit < 130 g/L) for males, platelets < 130,000 per µL, (SI unit
             < 130 × 109/L), albumin < 3.5 g/dL,(SI unit < 35 g/L), international normalized ratio
             (INR) > 1.5, total bilirubin > 1.2 mg/dL, (SI unit > 20.52 µmol/L), or
             alpha-fetoprotein (AFP) > 50 ng/mL (SI unit > 180.25 nmol/L). Subjects with an
             elevated indirect bilirubin and known Gilbert's disease can be included if direct
             bilirubin is within normal limits. Subjects with an AFP > 50 ng/mL but ˂ 500 ng/mL can
             be included if computed tomography (CT) scan or magnetic resonance imaging (MRI)
             performed within 3 months shows no evidence of hepatocellular carcinoma

          5. Creatinine > 1.2 mg/dL, (SI unit > 106.08 µmol/L), creatinine clearance < 50 mL/min,
             (SI unit < 0.83 L/s/m2)

          6. Co-infection with hepatitis C virus (HCV), human immunodeficiency virus (HIV), or
             hepatitis D virus

          7. Evidence or history of hepatocellular carcinoma

          8. Malignancy within 5 years prior to Screening, with the exception of specific cancers
             that are cured by surgical resection (basal cell skin cancer, etc). Subjects under
             evaluation for possible malignancy are not eligible.

          9. Significant cardiovascular, pulmonary, or neurological disease

         10. Received solid organ or bone marrow transplant

         11. Received within 3 months of Screening or expected to receive prolonged therapy with
             immunomodulators (eg, corticosteroids) or biologics (eg, monoclonal antibody, IFN)

         12. Subjects currently taking medication(s) that are transported through organic anion
             transporting polypeptide 1 (OATP1) including, but not limited to, atazanavir,
             rifampin, cyclosporine, eltrombopag, gemfibrozil, lopinavir/ritonavir, and saquinavir

         13. Use of another investigational agent within 3 months of Screening

         14. Current alcohol or substance abuse judged by the Investigator to potentially interfere
             with compliance

         15. Females who are pregnant or may wish to become pregnant during the study

         16. If the Investigator believes the prospective subject will not be able to comply with
             the requirements of the protocol and complete the study

         17. Any medical condition, in the opinion of the Investigator, that could interfere with
             evaluation of the study objectives or safety of the subjects

        Exclusion Criteria for Extension Period Subjects who meet any of the following exclusion
        criteria are not to be enrolled into the Extension Period:

          1. Any condition, comorbidity, or laboratory abnormality that, based on the package
             insert of tenofovir or in the opinion of the Investigator, excludes the subject

          2. Subjects who were withdrawn from Part A or Part B due to an AE or serious adverse
             event (SAE) related to the use of tenofovir

          3. Participation in any other interventional study

          4. Subject fully terminated from Part A or Part B
      