['non-hodgkin lymphoma']
['brentuximab vedotin']

        Inclusion Criteria:

          1. Patients must have histologically confirmed non-Hodgkin lymphomas with CD 30
             expression. Criteria of positive CD30 expression are defined as in cases with
             membranous CD30 expression from more than 50% of neoplastic cells.

          2. Relapsed or progressed disease after two or more than two salvage chemotherapy

          3. Patients must have fully recovered from the acute toxic effects of all prior
             chemotherapy, immunotherapy, or radiotherapy prior to entering this study.

          4. Measurable disease > 1.5 cm evidenced by computed tomography (CT) scan of the
             neck/chest/abdomen/pelvis or CT/positron emission tomography (PET) scans

          5. Life expectancy of greater than 3 months

          6. ECOG performance status ≤ 2

          7. Male or female patients 18 - 75 years

          8. Female patient is either post-menopausal for at least 1 year before the screening
             visit or surgically sterile or if of childbearing potential, agree to practice 2
             effective methods of contraception, at the same time, from the time of signing the
             informed consent through 6 months after the last dose of study drug, or agrees to
             completely abstain from heterosexual intercourse.

          9. Male patients, even if surgically sterilized, (i.e., status post vasectomy) agree to
             practice effective barrier contraception during the entire study period and through 6
             months after the last dose of study drug, or agrees to completely abstain from
             heterosexual intercourse.

         10. Voluntary written informed consent must be given before performance of any
             study-related procedure not part of standard medical care, with the understanding that
             consent may be withdrawn by the patient at any time without prejudice to future
             medical care.

         11. Clinical laboratory values as specified below within 7 days before the first dose of
             study drug:

         12. Serum creatinine must be < 2.0 mg/dL and/or creatinine clearance or calculated
             creatinine clearance > 40 mL/minute.

         13. Hemoglobin must be ≥ 8g/dL.

         14. Absolute neutrophil count (ANC) ≥ 1500/uL

         15. Platelets (Plts) ≥ 75,000/; G-CSF can be given prior to start of brentuximab vedotin
             and during brentuximab vedotin treatment to achieve target ANC; platelet transfusion
             can also be given prior to the start of brentuximab vedotin and during brentuximab
             vedotin treatment to achieve a target platelet ≥ 75,000/uL

         16. Total bilirubin within 1.5 x of the upper limit of normal (ULN) institutional limits,
             patients with elevation of unconjugated bilirubin alone, as in Gilbert's disease, are
             eligible

         17. Aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 2.5 X institutional
             ULN. AST and ALT may be elevated up to 5 times the ULN if their elevation can be
             reasonably ascribed to the presence of hematologic/solid tumor in liver

        Exclusion Criteria:

          1. Hodgkin lymphoma

          2. Anaplastic large cell lymphoma

          3. Female patient who are both lactating and breast-feeding or have a positive serum
             pregnancy test during the screening period or a positive pregnancy test on Day 1
             before first dose of study drug

          4. Any serious medical or psychiatric illness that could, in the investigator's opinion,
             potentially interfere with the completion of treatment according to the protocol.

          5. Known cerebral or meningeal disease (HL or any other etiology), including signs or
             symptoms of PML

          6. Symptomatic neurologic disease compromising normal activities of daily living or
             requiring medications

          7. Any sensory or motor peripheral neuropathy greater than or equal to Grade 2

          8. Any active systemic viral, bacterial, or fungal infection requiring systemic
             antibiotics within 2 weeks prior to first study drug dose

          9. Any prior treatment with chemotherapy and/or investigational agents completed less
             than 5 half-lives

         10. Known hypersensitivity to recombinant proteins, murine proteins, or to any excipient
             contained in the drug formulation of brentuximab vedotin.

         11. Known HIV antibody-positive

         12. Known hepatitis B surface antigen-positive, or known or suspected active hepatitis C
             infection

         13. Diagnosed or treated for another malignancy within 3 years before the first dose or
             previously diagnosed with another malignancy and have evidence of residual disease.
             Patients with nonmelanoma skin cancer or carcinoma in situ of any type are not
             excluded if they have undergone complete resection.

         14. Known history of any of the following cardiovascular conditions:

               -  Myocardial infarction within 2 years of first dose of study drug

               -  New York Heart Association (NYHA) Class III or IV heart failure (see Appendix 3)

               -  Evidence of current uncontrolled cardiovascular conditions, including cardiac
                  arrhythmias, congestive heart failure (CHF), angina, or electrocardiographic
                  evidence of acute ischemia or active conduction system abnormalities

               -  A left-ventricular ejection fraction <50% documented within 6 months before first
                  dose of study drug
      