['ankylosing spondylitis']
['nanocurcumin', 'placebo']

        Inclusion Criteria:

          -  Willingness to cooperate

          -  Aged 22 to 50 years

          -  The diagnosis of ankylosing spondylitis by rheumatologist

          -  Patients with a BASDAI > 4 as having active disease.

          -  Disease duration 5-8 years

        Exclusion Criteria:

          -  Nutritional supplements and antioxidant alpha-lipoic acid a month before the study.

          -  Pregnancy and lactation

          -  History of diabetes and other chronic diseases

          -  History of other autoimmune diseases

          -  Occurrence of relapses during the study period

          -  Acceptance rate of less than 70% of supplements

          -  Unwillingness to continue to cooperate
      