['acute pain']
['wafermine', 'oxycodone', 'placebo']

        Inclusion Criteria:

          -  Scheduled for a bunionectomy (with no additional procedures).

          -  Healthy, ambulatory subjects able to understand and willing to comply with study
             procedures, study restrictions and requirements.

          -  Body mass index (BMI) ≥19 to ≤33 kg/m2.

          -  Females: Not pregnant, not lactating, and not planning to become pregnant during the
             study.

          -  Females: Be abstinent, surgically sterile, at least two years post-menopausal; or
             medically acceptable contraception.

          -  Able to read and understand English.

          -  Able to swallow oral capsules whole.

        Exclusion Criteria:

          -  Allergy, intolerance, or contraindication to ketamine, oxycodone, morphine, ibuprofen
             or surgical medications.

          -  Clinically significant medical condition.

          -  History of illicit drug use or alcohol abuse and not in full remission.

          -  Positive test for human immunodeficiency virus (HIV), hepatitis B virus (HBV), or
             hepatitis C virus (HCV) at the screening visit.

          -  Clinically significant 12 lead ECG abnormalities at screening.

          -  Smokers who are unwilling to abstain during the inpatient stay.
      