['type 2 diabetes mellitus']
['pex168(100µg)', 'pex168(200µg)', 'placebo', 'metformin']

        Inclusion criteria：

          1. Type 2 diabetes mellitus confirmed by the 1999 WHO criteria

          2. Men or women

          3. Age at signing the ICF≥18 years and ≤78 years

          4. Body mass index (BMI) 20-40 Kg/m2

          5. At least 8 weeks of metformin monotherapy received prior to screening

          6. No glucose-lowering medications other than metformin received within the 8 weeks prior
             to screening

          7. 7.5%≤HbA1c≤11.0% at screening（local or centralized test 7.0%≤HbA1c≤10.5% at
             randomization (centralized test)

          8. Ability to understand the procedures and approach of this study, willingness to
             complete the study in strict compliance with the protocol and to voluntarily sign the
             ICF

        Exclusion criteria (subject to be excluded if meeting any of the followings)

          1. Investigator suspecting the subject of allergy to the study drug

          2. Use of any of the following medications or therapies prior to screening

               -  GLP-1 receptor agonists, GLP-1 analogues, DPP-4 inhibitors or any other incretin
                  analogues

               -  Growth hormone therapy within the 6 months prior to screening

               -  History of drug abuse or alcohol abuse

               -  Participation in any clinical trial for a pharmaceutical product or medical
                  device within the 3 months prior to screening

               -  Prolonged (for at least 7 consecutive days) intravenous, oral or intraarticular
                  treatment with corticosteroids within the 2 months prior to screening

               -  Use of any weight control agents or surgeries that might lead to unstable weight
                  within the 2 months prior to screening, or subjects currently on a weight loss
                  plan not in the maintenance phase

               -  Any medications used prior to screening that at the investigator's discretion may
                  confound the interpretation of the efficacy or safety data, or use of any
                  medications that may cause common toxicities to major organs, including Chinese
                  herbal medicine

          3. History or evidence of any of the following conditions prior to screening：

               -  Type 1 diabetes mellitus, single gene mutation DM, DM associated with pancreatic
                  injury， or secondary DM, e.g., DM secondary to Cushing syndrome or acromegalia

               -  History of hypertension with SBP>160 mmHg and/or DBP>100 mmHg despite
                  glucose-lowering agents at stable dose (for at least 4 weeks)

               -  History of acute/chronic pancreatitis, history of symptomatic cholecystopathy,
                  and the risk factors for pancreatitis including pancreatic injury

               -  History of myeloid C-cell carcinoma, history of multiple endocrine neoplasm （MEN）
                  2A or 2B syndrome, or related familiar history

               -  Clinically significant gastric emptying disorders, severe chronic
                  gastrointestinal disorders, prolonged treatment with peristalsis stimulants, or
                  gastrointestinal surgery

               -  History of severe hypoglycemic episode, or severe hypoglycemia without symptoms

               -  Significant hematological disorders , or any diseases that may lead to hemolysis
                  or unstable RBC

               -  Severe diabetic complications (e.g., macrovascular and microvascular
                  complications) that in the opinion of the investigator make the subject not
                  suitable to participate in this study

               -  Tumors of any organ or system that have or have not been treated within the 5
                  years prior to screening, regardless of whether there is evidence of relapse or
                  metastasis, with the exception of local basal cell carcinoma of the skin

               -  Coronary angioplasty, coronary stenting, coronary artery bypass, uncompensated
                  heart failure （NYHA Class III or IV）, stroke or transient cerebral ischemic
                  attack, unstable angina, myocardial infarction, and persistent and clinically
                  significant arrhythmia, experienced within the 6 months prior to screening

               -  Acute metabolic complications (e.g., ketoacidosis, lactic acidosis, hyperosmolar
                  coma) within the 6 months prior to screening

               -  Thyroid dysfunction treated with unstable therapeutic doses (e.g., thioureas,
                  thyroid hormones) within the 6 months prior to screening

               -  Blood lipid disorders treated with unstable therapeutic doses (e.g., statins,
                  fibrates) within the 6 months prior to screening

               -  Any severe trauma or severe infection that may interfere with BG control within
                  the 1 month prior to screening

          4. Laboratory indicators meeting any of the following criteria prior to screening (any
             test meeting the criteria must be repeated within 3 work days for confirmation)

               -  ALT>2.5×ULN and/or AST>2.5×ULN and/or total bilirubin>2.5×ULN

               -  Hemoglobin≤100 g/L

               -  Serum creatinine>1.5×UNL and eGFR < 45 ml/min/1.73 m2 eGFR is calculated as：186.3
                  ×[（Serum Creatinine（mmol/L）/88.4）]-1.154 × [Age (years)]- 0.203 × 1.223 × 0.742
                  （Females） or ×1（Males）

               -  Serum thyroid-stimulating hormone（TSH） out of the reference range that is
                  assessed as clinically significant by the investigator

               -  Fasting TGL>5.64 mmol/L（500 mg/dl)

               -  Blood amylase and urine amylase>ULN that is assessed as clinically significant by
                  the investigator

               -  Any clinically significant laboratory abnormalities that at the investigator's
                  discretion may confound the interpretation of the efficacy or safety data

          5. Clinically significant 12-lead ECG abnormalities, e.g., Grade II or III atrial
             ventricular block （with the exception of right bundle branch block），long QT syndrome
             or QTc>500ms

          6. Blood donation or loss≥400 mL，or receipt of blood donation within the 4 weeks prior to
             screening

          7. Pregnant or lactating women, or men or women of child-bearing potential not willing to
             take contraceptive measures during the study

          8. Any other conditions of the subject that at the investigator's discretion may compound
             the interpretation of the efficacy or safety data
      