['acute and chronic inflammation', 'dyspepsia']
['nimesulide + pantoprazole', 'naproxen + esomeprazole']

        Inclusion Criteria:

          -  Adults male or female aged ≥ 18 years old;

          -  Comply with all the purposes and procedures of the study by signing and dating the
             Informed Consent.

          -  Acute or chronic osteo-articular injury in need of of anti-inflammatory for a period
             of 14 days.

        Exclusion Criteria:

          -  Pregnant women, or women in childbearing age who are not in use effective
             contraception or intending to become pregnant during the study period

          -  History of peptic ulcer or gastric surgery;

          -  Use of Non-steroidal anti-inflammatory (NSAIDs), aspirin, proton pump inhibitor
             (PPIs), H2 blocker and antacid in the past 7 days;

          -  Contraindication to the use of NSAIDs or PPIs;

          -  Renal or hepatic impairment;
      