
    difficulty in enrollment
  
['myocardial reperfusion injury']
['milrinone', 'esmolol', 'saline infusion']

        Inclusion Criteria:

          -  Men and women, 18 years of age or older, who present within 12 hours after the onset
             of chest pain, who has ST-segment elevation of more than 0.1 mV in two contiguous
             leads, and for whom the clinical decision is made to treat with PCI will be eligible
             for enrollment.

        Exclusion Criteria:

          -  Patients with cardiac arrest, ventricular fibrillation, cardiogenic shock, previous
             acute myocardial infarction will not included in the study. Patients with occlusion of
             the left main will be excluded. Patients with baseline heart rate <50 beats/min and
             systolic BP<90 mmHg and pregnant patients will excluded. Finally, patients who have
             any disorder that is associated with immunologic dysfunction (e.g., cancer, lymphoma,
             a positive serologic test for the human immunodeficiency virus, or hepatitis) more
             recently than 6 months before presentation will be excluded.
      