['pain', 'osteoarthritis of the knee']
['neo6860', 'neo6860 placebo', 'naproxen', 'naproxen placebo']

        Inclusion Criteria:

          -  Body mass index (BMI) between 18.0 and 35.0 kg/m2 inclusive;

          -  Patients diagnosed with osteoarthritis of the knee, according to American College of
             Rheumatology (ACR) guidelines, by meeting at least 3 of the following: age > 50,
             morning stiffness < 30 minutes, crepitus on active motion, bone tenderness, bone
             enlargement, no palpable warmth of synovium;

          -  Grade I, II or III using Kellgren-Lawrence classification on an X-Ray of the knee

          -  WOMAC pain subscale ≥ 8

          -  R square of the Focused Analgesia Selection Task (FAST) outcome value greater than
             0.70

        Exclusion Criteria:

          -  Patients with, or with a history of, any clinically significant disorders (including
             fibromyalgia and other painful disorders) which may interfere with the primary
             objectives of the study

          -  Patients treated in the previous 3 months with topical capsaicin or intra-articular
             corticosteroids;

          -  Patients with a contra-indication for the use of Naproxen or acetaminophen;
      