
    significant recruitment delay in poc part
  
['healthy volunteers', 'asthma']
['rp3128', 'placebo']

        Inclusion Criteria:

          -  Male and non-childbearing female subjects (SAD/MAD) and male and non-childbearing
             female patients with mild asthma;

          -  Healthy subjects as determined by past medical history, vitals, physical examination
             and 12-lead ECG, clinical laboratory tests.

          -  Body mass index (BMI) between 18.0 and 30.0 kg/m2 inclusive, weight ≥50 kg;

          -  Non-smokers or ex-smokers

          -  Willingness to adhere to the protocol requirements as evidenced by the informed
             consent form (ICF) duly read, signed and dated by the subject; able to comply with
             protocol requirements and or study procedure;

          -  Negative screen for drugs of abuse and alcohol at screening and on admission.

          -  Male subjects should agree not to donate sperm for 3 months post dose; and

          -  Female partners (of child bearing potential) of male subjects should use 2 methods of
             highly effective contraception for 3 months post last

        Additionally for POC

          -  Pre- bronchodilator Forced expiratory volume in 1 sec( FEV1) of > 70% (adjusted for
             age, sex and race)

          -  Steroid naïve subjects with history of mild asthma that satisfy the Global Initiative
             for Asthma (GINA) definition of asthma, but otherwise healthy.

        Exclusion Criteria:

          -  Subjects with evidence or history of clinically significant medical history.

          -  History of tuberculosis (TB) and/or a positive Tuberculin Skin Test and/or
             QuantiFeron- TB®-Gold test.

          -  Use of any immunotherapy within 3 months prior to screening.

          -  History of serious adverse reaction, severe hypersensitivity or allergy to any
             drug/drug substance (except house dust mite, pollen allergens or cat dander allergy in
             asthmatics) or in any other circumstance (e.g. anaphylaxis);

          -  Abnormal liver function

          -  Positive screen on hepatitis-B surface antigen (HBsAg), antibodies to the hepatitis C
             (HCV) or antibodies to the human immunodeficiency virus (HIV) 1,2;
      