['gastric cancer']
['s1/paclitaxel chemotherapy plus apatinib']

        Inclusion Criteria:

          -  unresectable gastric cancer as proven histologically(AJCC, version 7) under any
             following condition: unable radical excision due to the local metastasis of invasion
             metastasis to the lymph node beside the abdominal aorta, non-extensive metastasis to
             liver( not more than three metastatic foci of radical excision), Peritoneal
             metastasis(CY1,P1,P2), kukerburg tumor

          -  Definitely diagnosed as above stage of gastric cancer before operation via CT of MRI,
             ultrasonic endoscopy, PET-CT, or through the laparoscopic exploration if necessary

          -  Untreated(e.g. radiotherapy, chemotherapy, target therapy and immunotherapy)

          -  Negative HER-2 state

          -  ECOG(Eastern Cooperative Oncology Group) :0~2

          -  Age: 18~75 years old

          -  Normal hemodynamic indices before the recruitment(including blood cell count and
             liver/kidney function ). For example: WBC>4.0*109/L, NE>1.5*109/L, PLT>100*109/L,
             BIL<1.5 times of upper limit of normal reference value, ALT and AST<2.5 times of upper
             limit of normal reference value, and CRE<1.2mg/dl

          -  Good cardiac function before the recruitment, no seizure of myocardial infarction in
             past half years, and controllable hypertension and other coronary heart disease

          -  Not concomitant with other uncontrollable benign disease before the recruitment(e.g.
             the infection in the kidney, lung and liver)

          -  Not participating in other clinical trials before and during the treatment

          -  Signed the Informed Consent Form

        Exclusion Criteria:

          -  not conforming above inclusion conditions

          -  Distal metastasis to lung, brain, and bone

          -  Ever operation on the stomach

          -  Operation intolerance due to other systemic basic disease

          -  Ever administrated with other drugs(including TCM drugs) before the recruitment, or no
             guarantee of progress according to the study requirement after recruitment

          -  Allergy to the drugs in this protocol

          -  Pregnant and lactating women

          -  Women at childbearing age and of pregnancy desire during the study
      