['portal vein thrombosis']
['npb-06', 'placebo']

        Inclusion Criteria:

        Inpatients or outpatients meet the criteria (1)-(4) below will be enrolled in the study.
        Patients have to provide written informed consent for voluntary participation in the study.

          1. Patients who the serum level of AT-III is 70% or less

          2. Patients with portal vein thrombosis detected by ultrasonography

          3. Patients who have more than 50% of the thrombus lumen occupancy

          4. Patients who are older than 20 years at the time of consent

        Exclusion Criteria:

        Patients who meet any of the following criteria will be excluded from the study beforehand.

          1. Patients with tumor embolus in portal vein

          2. Patients with an ongoing hepatic intra-arterial chemotherapy such as implantable
             reservoir system

          3. Patients with hepatocellular cancer of more than 3 cm in diameter or more than four
             hepatocellular cancers

          4. Patients with residual or chronic portal vein thrombosis

          5. Patients with advanced liver disease (Child-Pugh score 11 or more)

          6. Patients with bleeding tendency

          7. Patients who had an anticoagulation therapy (intravenous or subcutaneous dose) or
             hemostasis with an enzymatic hemostatic agent in the period between 7 days before
             contrast enhanced CT of pre-dose and the day acquired written informed consent

          8. Patients who had an anticoagulation therapy (oral dose) in the period between 7 days
             before contrast enhanced CT of pre-dose and the day acquired written informed consent

          9. Patients with a history of shock or hypersensitivity to NPB-06

         10. Patients with inappropriate to contrast agents

               -  A history of allergy of iodine or X-ray contrast agent

               -  Complication of serious thyroid disease

               -  Reduced renal function

         11. Pregnant or lactating women, women of childbearing potential, or women who plan to
             become pregnant during the study

         12. Patients who have received NPB-06

         13. Patients who have received other investigational drugs within four months before
             consent or who are participating in other clinical studies

         14. Patients otherwise ineligible for participation in the study in the investigator's or
             subinvestigator's opinion
      