['anemia', 'b-cell prolymphocytic leukemia', 'grade 1 follicular lymphoma', 'grade 2 follicular lymphoma', 'grade 3a follicular lymphoma', 'hairy cell leukemia', 'lymphoplasmacytic lymphoma', 'mantle cell lymphoma', 'marginal zone lymphoma', 'recurrent chronic lymphocytic leukemia', 'recurrent small lymphocytic lymphoma', 'refractory chronic lymphocytic leukemia', 'refractory small lymphocytic lymphoma', 'richter syndrome']
['entospletinib']

        Inclusion Criteria:

          -  Phase I portion of the study: Histologically or flow cytometry confirmed diagnosis of
             B-CLL/SLL according to National Cancer Institute (NCI)-Working Group (WG) 1996
             guidelines

          -  Phase I portion of the study: The following types of NHL as documented by medical
             records and with histology based on criteria established by the World Health
             Organization (WHO):

               -  Mantle cell lymphoma (MCL)

               -  Follicular lymphoma (FL) - grades 1-3a

               -  Lymphoplasmacytic lymphoma (LPL)

               -  Marginal zone lymphoma (MZL)

               -  CLL in Richter's transformation

               -  B-cell prolymphocytic leukemia

          -  Phase I portion of the study: Patients with histologically confirmed classical hairy
             cell leukemia (HCL)

          -  Phase II portion of the study - histologically or flow cytometry confirmed diagnosis
             of BCLL/SLL according to NCI-WG 1996 guidelines; patients who lack CD23 expression on
             their leukemia cells should be examined for (and found NOT to have) either t(11;14) or
             cyclin D1 overexpression, to rule out mantle cell lymphoma

          -  Patients underwent >= 1 prior chemotherapy-based or immunotherapy-based regimen or
             targeted therapy (e.g., inhibitors of BTK, PI3K etc.) administered for >= 2 cycles,
             and have had either documented disease progression or no response (stable disease) to
             the most recent treatment regimen

          -  Patients with CLL/SLL must demonstrate active disease meeting at least 1 of the
             International Workshop on Chronic Lymphocytic Leukemia (IWCLL) 2008 criteria for
             requiring treatment:

               -  A minimum of any one of the following constitutional symptoms:

                    -  Unintentional weight loss > 10% within the previous 6 months prior to
                       screening

                    -  Extreme fatigue (unable to work or perform usual activities)

                    -  Fevers of greater than 100.5 Fahrenheit (F) for >= 2 weeks without evidence
                       of infection

                    -  Night sweats without evidence of infection

               -  Evidence of progressive marrow failure as manifested by the development of, or
                  worsening of anemia or thrombocytopenia

               -  Massive (i.e., > 6 cm below the left costal margin), progressive or symptomatic
                  splenomegaly

               -  Massive nodes or clusters (i.e., > 10 cm in longest diameter) or progressive
                  lymphadenopathy

               -  Progressive lymphocytosis with an increase of > 50% over a 2-month period, or an
                  anticipated doubling time of less than 6 months

               -  Autoimmune anemia or thrombocytopenia that is poorly responsive to
                  corticosteroids

          -  Patients with HCL must be intolerant of or not candidates for purine analog-based
             therapy, or failed to achieve response (CR or partial response [PR]) or relapsed
             within 2 years of such therapy, AND meet the standard treatment initiation criteria
             (absolute neutrophil count [ANC] =< 1000/uL, hemoglobin [Hgb] =< 10 g/dL, platelet
             count =< 100,000/uL); patients with indolent lymphoma (FL, LPL, MZL) and patients with
             B-cell prolymphocytic leukemia must have an indication for treatment in the opinion of
             the investigator; patients with MCL and patients with CLL in Richter's transformation
             should have previously received or not be candidates for high dose
             chemotherapy/autologous stem cell transplant

          -  For diseases other than CLL, LPL, and HCL, presence of radiographically measurable
             lymphadenopathy or extra-nodal lymphoid malignancy (defined as the presence of >= 1
             lesion that measures >= 2.0 cm in the longest dimension [LD] and >= 1.0 cm in the
             longest perpendicular dimension [LPD] as assessed by computed tomography [CT] or
             magnetic resonance imaging [MRI]); for LPL, measurable disease will be defined as
             serum monoclonal IgM > 0.5 g/dL or meeting at least 1 of the recommendations from the
             Second International Workshop on LPL for requiring treatment

          -  Patients must have Eastern Cooperative Oncology Group (ECOG) performance status =< 2

          -  Direct bilirubin =< 2 X institutional upper limit of normal (ULN) (unless due to known
             Gilbert's syndrome or compensated hemolysis directly attributable to CLL)

          -  Aspartate aminotransferase (AST) or alanine aminotransferase (ALT) less than 2.5 X
             institutional ULN

          -  Estimated creatinine clearance (CrCL) using the Cockcroft-Gault equation >= 50 mL/min

          -  Platelets >= 50,000/mm^3 independent of transfusion support, with no active bleeding

          -  Absolute neutrophil count (ANC) >= 1000/mm^3, unless due to disease involvement in the
             bone marrow

          -  Ability to understand and the willingness to sign a written informed consent document

        Exclusion Criteria:

          -  Prior therapeutic intervention with any of the following:

               -  Therapeutic anticancer antibodies within 4 weeks (rituximab), except within 6
                  months for obinutuzumab or a similar investigational type II monoclonal antibody;

               -  Radio- or toxin-immunoconjugates within 10 weeks;

               -  Inhibitors of BTK (ibrutinib), PI-3K (idelalisib), BH3-mimetic venetoclax,
                  lenalidomide and other "targeted" therapy (including but not limited to
                  investigational BTK and PI-3K inhibitors, etc.) - within 6 half-lives (i.e., 36
                  hours for ibrutinib)

               -  All other chemotherapy, radiation therapy within 3 weeks prior to initiation of
                  therapy

               -  SYK inhibitors at any time

          -  Inadequate recovery from adverse events related to prior therapy to grade =< 1
             (excluding grade 2 alopecia and neuropathy)

          -  Chronic use of corticosteroids in excess of prednisone 30 mg/day or its equivalent

          -  Stem cell transplant recipients must have no evidence of and not receive treatment for
             graft-versus-host disease

          -  Concomitant use or use in the prior two weeks of moderate or strong CYP3A and CYP2C9
             inducers or strong CYP2C9 inhibitors, including nutraceutical preparations, e.g.,
             grapefruit juice and St John's wort

          -  History prior malignancy except:

               -  Malignancy treated with curative intent and no known active disease present for
                  >= 2 years prior to initiation of therapy on current study

               -  Adequately treated non-melanoma skin cancer or lentigo maligna (melanoma in situ)
                  without evidence of disease

               -  Adequately treated in situ carcinomas (e.g., cervical, esophageal, etc.) without
                  evidence of disease

               -  Asymptomatic prostate cancer managed with "watch and wait" strategy

               -  Myelodysplastic syndrome which is clinically well controlled and no evidence of
                  the cytogenetic abnormalities characteristic of myelodysplasia on the bone marrow
                  at screening

          -  Uncontrolled immune hemolysis or thrombocytopenia (positive direct antiglobulin test
             in absence of hemolysis or history of immune-mediated cytopenias are not exclusions)

          -  History of human immunodeficiency virus (HIV) infection or active hepatitis B or C

          -  Major surgery (requiring general anesthesia) within 2 weeks prior to initiation of
             therapy

          -  Inability to swallow and retain an oral medication; patients with clinically
             significant medical condition of malabsorption, inflammatory bowel disease, chronic
             conditions which manifest with diarrhea, refractory nausea, vomiting or any other
             condition that will interfere significantly with drug absorption are excluded;
             patients must also have adequate venous access

          -  Need for ongoing therapy with proton pump inhibitors; H2 antagonists are allowed

          -  Active uncontrolled infection

          -  Women who are pregnant or lactating

          -  Fertile men or women of childbearing potential unless 1) permanently sterile or 2)
             using a highly effective measure of contraception such as condoms in males and
             consistent and correct use of one of the following in females: intrauterine device,
             tubal sterilization, Essure micro-insert system, vasectomy in the male partner;
             effective contraception is required for males during treatment with study drug and to
             continue for 3 months after the last dose of either entospletinib or obinutuzumab,
             whichever is later; for women, effective contraception is required to continue for 18
             months after the last dose of obinutuzumab or for 30 days after the last dose of
             entospletinib, whichever is later

               -  Definition of childbearing potential: for this study, a female subject is
                  considered of childbearing potential until becoming post-menopausal unless
                  permanently sterile or with medically documented ovarian failure; women are
                  considered to be in a postmenopausal state when >= 54 years of age with cessation
                  of previously occurring menses for >= 12 months without an alternative cause;
                  women of any age with amenorrhea of >= 12 months may also be considered
                  post-menopausal if their follicle stimulating hormone (FSH) level is in the
                  post-menopausal range and they are not using hormonal contraception or hormonal
                  replacement therapy; permanent sterilization in females includes hysterectomy,
                  bilateral oophorectomy, or bilateral salpingectomy in a female subject of any
                  age; permanent sterilization in males include bilateral orchiectomy or medical
                  documentation of alternative explanation

          -  Any condition for which participation in the study is judged by the Investigator to be
             detrimental to the patient with inter-current illness or psychiatric/social situations
             that would jeopardize compliance with study requirements
      