['chronic graft-versus-host disease']
['r348 ophthalmic solution, 0.2%', 'r348 ophthalmic solution, 0.5%']

        Inclusion Criteria:

          -  Received an Allogeneic hematologic stem cell transplantation at least 3 months prior.

          -  Subjects with post Allogeneic hematologic stem cell transplantation onset or worsening
             of dry eye symptoms for at least 1 month prior.

          -  Use of over-the-counter and/or prescription eye drops for dry eye symptoms within 1
             month.

          -  Corneal fluorescein staining score of ≥ 2 in 1 region and ≥ 1 in at least 1 other
             region.

          -  Total lissamine green conjunctival staining score (according to a modified National
             Eye Institute grading system) of ≥ 2.

        Exclusion Criteria:

          -  Clinically unstable Graft versus Host Disease (requiring a change in immunosuppressive
             regimen), medical condition, or laboratory abnormality

          -  Used topical ophthalmic cyclosporine within 45 days.

          -  Used any topical ophthalmic steroid within 2 weeks.

          -  Used autologous serum eye drops within 2 weeks.
      