
    difficulty accruing subjects the study accrual was closed
  
['metastatic breast cancer']
['icotinib']

        Inclusion Criteria:

          -  Age 18 years or older

          -  ECOG 0 or 1

          -  Primary or metastatic tumor onfirmed as triple negative

          -  Measurable disease per RECIST version 1.1

          -  normal organ function, including bone marrow function, renal function, liver function,
             and cardiac function

          -  Two or more prior chemotherapy

          -  signed and dated an informed consent form

          -  Life expectancy of at least 12 weeks

        Exclusion Criteria:

          -  Pregnant or breast feeding

          -  ECOG score ≧2

          -  Uncontrolled medical problems

          -  Hepatic, renal, or bone marrow dysfunction as detailed above

          -  Concurrent malignancy or history of other malignancy within the last five years except
             as noted above

          -  Patients were unable or unwilling to comply with program requirements
      