['prostatic neoplasms']
['docetaxel', 'prednisone', 'enzalutamide']

        Inclusion Criteria:

          1. Histologically- or cytologically-confirmed prostate adenocarcinoma.

          2. Metastatic disease.

          3. Progressive disease while receiving hormonal therapy or after surgical castration
             documented by at least one of the following:

               -  Increase in measurable disease (RECIST 1.1) [15], and/or

               -  Appearance of new lesions, including those on bone scan consistent with
                  progressive prostate cancer, and/or

               -  Rising PSA defined as 2 sequential increases above a previous lowest reference
                  value. Each value must be obtained at least 1 week apart. A PSA value of at least
                  2 ng/ml is required at study entry.

               -  Effective castration (serum testosterone levels ≤0.50 ng/dL) by orchiectomy
                  and/or LHRH agonists or antagonist with or without anti-androgens.

                  i. If the patient has been treated with LHRH agonists or antagonist (i.e.,
                  without orchiectomy), then this therapy should be continued.

             ii. If patients were either started on complete androgen blockade, or had a PSA
             response (defined by any reduction in PSA sustained for at least 3 months) after
             adding an antiandrogen, prior anti-androgen therapy should be stopped before
             randomization: at least 6 weeks for bicalutamide and nilutamide, and at least 4 weeks
             for flutamide, megestrol acetate and any other hormonal therapy.

          4. More than 18 years.

          5. Eastern Cooperative Oncology Group (ECOG) performance status <2 (see Appendix 2).

          6. Ability to fill the quality of life questionnaire

          7. Patient compliance and geographic proximity that allow adequate follow-up.

          8. Presence of signed and dated IRB-approved patient informed consent form prior to
             enrollment into the study.

        Exclusion Criteria:

          1. Prior chemotherapy for prostate cancer, except estramustine and except
             adjuvant/neoadjuvant treatment completed >3 years ago.

          2. Prior treatment with abiraterone acetate and/or enzalutamide

          3. Less than 28 days elapsed from prior treatment with estramustine, radiotherapy or
             surgery to the time of randomization. Patients may be on biphosphonates prior to study
             entry.

          4. Prior isotope therapy, whole pelvic radiotherapy, or radiotherapy to >30% of bone
             marrow.

          5. History of brain metastases, uncontrolled spinal cord compression, or carcinomatous
             meningitis or new evidence of brain or leptomeningeal disease.

          6. History of seizure or any condition that may predispose to seizure (eg, prior cortical
             stroke or significant brain trauma). History of loss of consciousness or transient
             ischemic attack within 12 months of randomization;

          7. Inadequate organ and bone marrow function

          8. Contraindications to the use of corticosteroid treatment.

          9. Clinically significant cardiovascular disease

         10. Any of the following within 3 months prior to randomization: treatment resistant
             peptic ulcer disease, erosive esophagitis or gastritis, infectious or inflammatory
             bowel disease, diverticulitis, pulmonary embolism, or other uncontrolled
             thromboembolic event.

         11. Hypersensitivity reaction to the active pharmaceutical ingredient or any of the
             capsule components, including Labrasol, butylated hydroxyanisole, and butylated
             hydroxytoluene;

         12. Prior malignancy. Adequately treated basal cell or squamous cell skin or superficial
             (pTis, pTa, and pT1) bladder cancer are allowed, as well as any other cancer for which
             chemotherapy has been completed >5 years ago and from which the patient has been
             disease-free for >5 years.

         13. Participation in another clinical trial and any concurrent treatment with any
             investigational drug within 30 days prior to randomization.

         14. Any other condition which in the judgment of the investigator would place the subject
             at undue risk or interfere with the study.
      