
    insufficient accrual
  
['cutaneous melanoma', 'melanoma']
['sonazoid']

        Inclusion Criteria:

          -  Cutaneous melanoma with Breslow depth > 1 mm or melanoma Breslow depth of 0.76 - 1.00
             mm in setting of ulceration, extensive regression

          -  Mitotic rate >= 1/mm^2

          -  Presence of angiolymphatic invasion

          -  Deep positive margin

          -  No known allergies to contrast material

        Exclusion Criteria:

          -  Pregnant or nursing

          -  Patients with known cardiac shunt

          -  Patients with class II heart failure or worse, per New York Heart Association (NYHA)
             classification

          -  Patients who have experienced an acute coronary syndrome or angina in the past 6
             months

          -  Patients who have undergone coronary artery bypass grafting (CABG) or coronary
             stenting in the past 3 years

          -  Patients with evidence of moderate or severe cardiac valvular disease on
             echocardiogram

          -  Patients with evidence of moderate or severe pulmonary hypertension on echocardiogram

          -  Patients with stage II chronic obstructive pulmonary disease (COPD) or worse, per
             Global Initiative for Chronic Obstructive Lung Disease (GOLD) classification

          -  Patients with hypersensitivity to sonazoid or one of its components

          -  Patients with hypersensitivity to egg or egg products, because sonazoid contains a
             chicken egg-derived surfactant (hydrogenated egg phosphatidylserine sodium)

          -  Patients who cannot consent for themselves
      