['liver metastasis', 'colorectal cancer']
['decitabine']

        Inclusion Criteria:

          -  Histological documentation of colorectal adenocarcinoma CRC stage IV with predominant
             unresectable liver metastases and at least one measurable metastatic liver lesion

          -  Performance status WHO criteria of < 2.

          -  Laboratory values: absolute neutrophil count (ANC) count > 1500 /mm³, Platelet count >
             100 000 /mm³, Lymphocytes > 800 /mm³, Serum creatinine < 2.0 mg/dl or creatinine
             clearance >40 ml/min, Serum bilirubin < 2.0 mg/dl

          -  Progressive disease following standard of care palliative systemic chemotherapy

          -  able to give written informed consent.

        Exclusion Criteria:

          -  No prior radiotherapy to all target liver lesions

          -  No previous history of gastric or hepatobiliary surgery (except for simple
             cholecystectomy, No concurrent liver disease or other serious medical disease or
             condition

          -  No concomitant use of other investigational drugs.

          -  No pre-existing neuropathy with a severity of > grade 1 in the WHO toxicity scale.

          -  No previous or concurrent malignancies except for adequately treated in situ carcinoma
             of the cervix uteri, basal or squamous cell carcinoma of the skin or any other
             malignancy given potentially curative treatment more than 5 years before study entry

          -  No pregnant or breast-feeding female patients, use of an effective contraceptive if
             the risk of conception exists during study treatment.

          -  No candidate for the resection of all CRC metastases with curative intent.
      