['duchenne muscular dystrophy']
['(+)- epicatechin']

        Inclusion Criteria:

          -  Male

          -  Age 8 years to 17 years

          -  Non-Ambulatory (unable to complete 10m run/walk under 10s)

          -  Weight </=100Kg

          -  Diagnosis of DMD confirmed by at least one the following:

               -  Dystrophin immunofluorescence and/or immunoblot showing complete dystrophin
                  deficiency, and clinical picture consistent with typical DMD, or

               -  Gene deletions test positive (missing one or more exons) of the dystrophin gene,
                  where reading frame can be predicted as 'out-of-frame', and clinical picture
                  consistent with typical DMD, or

               -  Complete dystrophin gene sequencing showing an alteration (point mutation,
                  duplication, or other mutation resulting in a stop codon mutation) that can be
                  definitely associated with DMD, with a typical clinical picture of DMD, or

               -  Positive family history of DMD confirmed by one of the criteria listed above in a
                  sibling or maternal uncle, and clinical picture typical of DMD.

          -  Cardiac ejection fraction >55% on echocardiogram

          -  Use of nutritional, herbal and antioxidant supplements taken with the intent of
             maintaining or improving skeletal muscle strength or functional mobility has been
             discontinued at least 4 weeks prior to screening (daily multivitamin use is
             acceptable).

          -  Glucocorticoid therapy, if used, must have a stable weight-based dose for at least 3
             months prior to enrollment

          -  Cardiac therapy, if used, includes prophylactic ACE inhibitors, aldosterone receptor
             antagonists (e.g.

        spironolactone, eplerenone, etc.), and/or beta-blocker therapy, and must be stable for 3
        months prior to enrollment.

          -  Hematology profile within normal range.

          -  Baseline laboratory safety chemistry profile within typical range for DMD (elevated
             ALT / AST acceptable in the absence of elevated GGT, elevated CK acceptable).

        Exclusion Criteria:

          -  Inability to complete cardiac or strength, range of motion and mobility assessments
             per protocol

          -  Current enrollment in another treatment clinical trial.

          -  History of significant concomitant illness or significant impairment of renal or
             hepatic function.

          -  Use of regular daily aspirin or other medication with antiplatelet effects within 3
             weeks of first dose of study medication.

          -  Cardiac symptoms that, in the opinion of the investigator, may be suggestive of
             imminent moderate to severe cardiac events, irrespective of LVEF.
      