['hypertriglyceridemia', 'familial hypercholesterolemia']
['ionis angptl3-lrx', 'placebo']

        Inclusion Criteria for All Cohorts:

          -  Must have given written informed consent and be able to comply with all study
             requirements

          -  Males or females 18 to 65 years, inclusive, at the time of informed consent

          -  Body Mass Index (BMI) ≤ 35.0 kg/m2

          -  Females must be non-pregnant and non-lactating, and either surgically sterile or
             postmenopausal.

          -  Males must be surgically sterile, abstinent or using an acceptable contraceptive
             method

        Inclusion criteria for Cohorts, A, D, and AA to DD only:

          -  Fasting triglycerides (TG) ≥ 150 mg/dL at Screening

          -  Fasting low density lipoprotein cholesterol (LDL-C) > 70 mg/dL at Screening

        Inclusion criteria for Cohorts B and C only:

          -  Fasting TG 90 - 150 mg/dL at Screening

          -  Fasting LDL-C > 70 mg/dL at Screening

        Inclusion Criteria for Cohort EE Only:

          -  Homozygous FH diagnosis and fasting LDL-C ≥ 190 mg/dL (4.9 mmol/L)

        Inclusion Criteria for Cohort FF Only:

          -  Heterozygous FH diagnosis and fasting LDL-C ≥ 160 mg/dL (4.1 mmol/L)

        Inclusion Criteria for Cohorts EE and FF Only:

          -  Maximally tolerated stable LDL-C lowering agents (stable for at least 12 weeks)

          -  On stable low-fat diet

          -  Stable weight (± 4 kg) for ≥ 6 weeks prior to screening

        Exclusion Criteria for All Cohorts:

          -  Known history or positive test for Human Immunodeficiency Virus (HIV), Hepatitis C
             (HCV), or Hepatitis B (HBV)

          -  Treatment with another Study Drug, biological agent, or device within one-month or
             5-half-lives of screening

          -  Regular use of alcohol within 6 months of screening

          -  Use of concomitant drugs unless authorized by the Sponsor Medical Monitor

          -  Known contraindication and/or allergy to heparin

          -  Smoking > 10 cigarettes a day

          -  Considered unsuitable for inclusion by the Principal Investigator

        Exclusion Criteria for Cohorts EE and FF:

          -  Myocardial infarction, percutaneous transluminal coronary intervention, or coronary
             artery bypass graft surgery within 12 weeks prior to screening, or cerebrovascular
             accident within 24 weeks prior to screening. Participants with adequately treated
             stable angina, per Investigator assessment, may be included

          -  Congestive heart failure defined by NYHA Classes III or IV

          -  Type 2 diabetes mellitus (T2DM) with HbA1c > 8.0%

          -  Prior treatment with gene therapy

          -  Currently receiving apheresis treatments or last apheresis treatment was within 8
             weeks of screening
      