['small cell lung carcinoma']
['atezolizumab (mpdl3280a), an engineered anti-pd-l1 antibody', 'carboplatin', 'etoposide', 'placebo']

        Inclusion Criteria:

          -  Histologically or cytologically confirmed ES-SCLC (per the Veterans Administration
             Lung Study Group [VALG] staging system)

          -  No prior systemic treatment for ES-SCLC

          -  Eastern Cooperative Oncology Group performance status of 0 or 1

          -  Measurable disease, as defined by RECIST v1.1

          -  Adequate hematologic and end organ function

          -  Treatment-free for at least 6 months since last chemo/radiotherapy, among those
             treated (with curative intent) with prior chemo/radiotherapy for limited-stage SCLC

        Exclusion Criteria:

          -  Active or untreated central nervous system (CNS) metastases as determined by computed
             tomography (CT) or magnetic resonance imaging (MRI) evaluation

          -  Malignancies other than SCLC within 5 years prior to randomization, with the exception
             of those with a negligible risk of metastasis or death treated with expected curative
             outcome

          -  Pregnant or lactating women

          -  History of autoimmune disease

          -  History of idiopathic pulmonary fibrosis, organizing pneumonia, drug-induced
             pneumonitis, idiopathic pneumonitis, or evidence of active pneumonitis on screening
             chest CT scan. History of radiation pneumonitis in the radiation field (fibrosis) is
             permitted.

          -  Positive test result for human immunodeficiency virus (HIV)

          -  Active hepatitis B or hepatitis C

          -  Severe infections at the time of randomization

          -  Significant cardiovascular disease

          -  Prior treatment with cluster of differentiation (CD) 137 agonists or immune checkpoint
             blockade therapies, anti-programmed death-1 (PD-1), and anti-PD-L1 therapeutic
             antibody

          -  History of severe (or known) hypersensitivity to chimeric or humanized antibodies or
             fusion proteins or any component of atezolizumab formulation.
      