['homozygous familial hypercholesterolemia']
['mbx-8025 50 mg (dose escalation period 1)', 'mbx-8025 50 mg or 100 mg (dose escalation period 2)', 'mbx-8025 50 mg, 100 mg or 200 mg (dose escalation period 3)']

        Inclusion Criteria:

          1. Must have given written informed consent (signed and dated) and any authorizations
             required by local law and be able to comply with all study requirements.

          2. Male or female with HoFH confirmed by genotype (two mutant alleles at the LDL-Receptor
             (LDL-R) gene locus or double heterozygotes LDL-R/Apo-B).

          3. 18 years of age or older.

          4. Existing lipid lowering therapies (statins, cholesterol absorption inhibitors, bile
             acid sequestrants, nicotinic acid and their combinations, low-density lipoprotein
             (LDL) LDL-C apheresis) on a stable regimen for at least four weeks before screening
             visit.

          5. Stable lipid lowering diet compatible with a Step I diet of the American Heart
             Association (AHA).

          6. Fasting LDL-C ≥ 4.8 mmol/L (≥ 185.6 mg/dL) during screening.

          7. For females or males of reproductive potential, use of at least one barrier
             contraceptive and a second effective birth control method during the study and for at
             least two weeks after the last dose.

        Exclusion Criteria:

          1. Treatment with lomitapide or mipomersen within two months of screening.

          2. Heart Failure (HF) with New York Heart Association (NYHA) class III and class IV or a
             Left ventricular ejection fraction (LVEF) of less than 30%.

          3. Uncontrolled cardiac arrhythmia during the past three months of screening.

          4. Myocardial infarction, unstable angina, percutaneous coronary intervention, coronary
             artery bypass graft or stroke during the past three months of screening.

          5. Planned cardiac surgery, or planned revascularization, in the next four months.

          6. Uncontrolled hypertension.

          7. Aspartate transaminase (AST) or Alanine transaminase (ALT) ≥ 3 times the Upper Limit
             of Normal (ULN).

          8. Unexplained creatine kinase (CK) ≥ 5 times the upper limit of normal (ULN).

          9. For females, pregnancy or breast-feeding.

         10. Any other condition(s) that would compromise the safety of the patient or compromise
             the quality of the clinical study as judged by the Investigator and/or Medical
             Monitor.
      