['hyperkalemia', 'resistant hypertension']
['patiromer', 'placebo', 'spironolactone']

        Inclusion Criteria:

          -  Age ≥ 18 years

          -  Taking at least three medications for blood pressure (one a diuretic)

          -  Uncontrolled high blood pressure

          -  Abnormal kidney function (with-eGFR, a measure of kidney function, of 25 - ≤ 45
             mL/min/1.73m2

          -  Normal Blood serum Potassium in a specific range (4.3 - 5.1 mEq/L)

        Exclusion Criteria:

          -  History of untreated known causes of high blood pressure, excluding kidney disease
             (not CKD)

          -  Inability to measure BP

          -  Not taking high blood pressure medications as prescribed medications

          -  Recent change in renal function (in the past 3 months) which has required
             hospitalization or dialysis

          -  Renal transplant

          -  History of cancer within past 12 months

          -  Recent cardiovascular event with last 3 months

          -  Clinically significant abnormalities of heart rhythm (ventricular arrhythmia or atrial
             fibrillation with uncontrolled heart rate)

          -  Inability to take study medication

          -  Alcoholism
      