['nasopharyngeal neoplasms']
['cc-486']

        Inclusion Criteria:

          -  Age = or > 18 years Histological or cytological diagnosis of undifferentiated or
             poorly differentiated nasopharyngeal carcinoma that is locally advanced or metastatic.

          -  Disease progression either clinically or radiographically after 1-2 previous regimens.

          -  Patient has received a platinum containing regimen. Eastern Cooperative Oncology Group
             (ECOG) performance status 0-2. Radiographically-documented measureable disease.

          -  Adequate organ and bone marrow functions.

          -  Willingness to follow pregnancy precautions.

        Exclusion Criteria:

          -  History of, or current brain metastasis. Any other malignancy within 5 years prior to
             randomization with the exception of adequately treated in situ carcinoma of the
             cervix, uteri, or non-melanomatous skin cancer (all treatment of which should have
             been completed 6 months prior to enrollment), in situ squamous cell carcinoma of the
             breast, or incidental prostate cancer.

          -  Previous treatment with azacitidine (any formulation), decitabine, any other
             hypomethylating agent.

          -  History of gastrointestinal disorder or defect. Impaired ability to swallow oral
             medication. Persistent diarrhea or malabsorption.

          -  Active cardiac disease and human immunodeficiency virus (HIV) infection

          -  Active bleeding; pathological condition that carries a high risk of bleeding; risk of
             pseudoaneurysm of the internal carotid artery and carotid blowout syndrome.

          -  Major surgery within 14 days prior to starting Investigational Product or has not
             recovered from major side effects.

          -  Another investigational therapy within 28 days or 5 half lives of
             randomization/enrollment, whichever is shorter.

          -  Patient has not recovered from the acute toxic effects of prior anticancer therapy,
             radiation, or major surgery/significant trauma.

          -  Radiotherapy < or = 4 weeks or limited field radiation for palliation < or = 2 weeks
             prior to starting with the investigational product.

          -  Pregnancy/Breast feeding

          -  Any condition that places the patient at unacceptable risk if he/she were to
             participate in the study or that confounds the ability to interpret data from the
             study.
      