['type 2 diabetes mellitus']
['lixisenatide', 'insulin glargine']

        Inclusion Criteria:

          -  Age 18 - 70a

          -  Subjects understand study related activities and give written informed concent

          -  HbA1c between 7 - 10 % under treatment with premixed insulin (2-3 injections)

        Exclusion Criteria:

          -  Females of child-bearing age

          -  History of hypoglycemia unawareness

          -  Gastrointestinal disease associated with prolonged nausea and vomiting

          -  Impaired liver function (transaminase >2x than normal)

          -  Impaired kidney function (creatinin > 1,2 mg/dl)

          -  Known intolerance against GLP-1 receptor agonists

          -  History of pancreatitis or pancreas tumor

          -  Malignancies, autoimmune diseases

          -  Severe dyslipidemia (serum triglycerides > 400 mg/dl, cholesterol > 300 mg/dl)

          -  Psychiatric disorder

          -  Oral glucose lowering medication except for metformin
      