
    slow recruitment
  
["crohn's disease"]
['adalimumab', 'placebo']

        Inclusion Criteria:

          -  Patients of both sexes older than 18 years

          -  Patient diagnosed of CROHN´s disease

          -  Patient with intestinal stenosis length equal or less than 5cm previously confirmed
             with bowel magnetic resonance imaging (3 stenosis as maximum)

          -  Stenosis no permeable for endoscopy(12mm in case of accessible stenosis with
             conventional colonoscopy and 10mm in case of accessible stenosis with balloon
             enteroscopy)

          -  Dilated stenosis according to endoscopist criteria (pass or no the endoscopy)

          -  Patient capable of participate in the examinations required by the study

          -  Patient after being informed, give his/her informed consent in writing

        Exclusion Criteria:

          -  Patients with large intestinal stenosis (more than 6cm) and multiples

          -  Patients with previous or actual treatment with anti-tumor necrosis factor (anti-TNF)
             drugs

          -  Patients with positive serology to hepatitis B virus(HBV),hepatitis C virus (HCV), or
             HIV

          -  Patients with positive screening to Tuberculosis(positive PPD)

          -  Established contraindication to anti-TNF drugs

          -  Existence of fistulous tracts associated with intestinal stenosis

          -  Neoplastic process associated with stenosis or in another location

          -  Pregnancy or breastfeeding
      