['head and neck cancer']
['metformin', 'cisplatin']

        Inclusion Criteria:

          -  Locally advanced squamous cell cancer of the head and neck, stage III or IV disease
             (T1-2, N2a-3 or T3-4).

          -  Measurable disease

          -  No prior chemotherapy or radiation for head and neck squamous cell cancer

          -  Life expectancy of greater than 3 months.

          -  Adequate labs

        Exclusion Criteria:

          -  Known metastatic disease.

          -  Nasopharyngeal carcinoma

          -  History of allergic reactions attributed to metformin or other agents used in study.

          -  Known diagnosis of diabetes requiring insulin for control.

          -  Administration of metformin within last 4 weeks.
      