['postpartum depression']
['sage-217', 'placebo']

        Key Inclusion Criteria:

          -  Subject either must have ceased lactating at screening or, if still lactating or
             actively breastfeeding at screening, must agree to temporarily cease giving breast
             milk to her infant(s)

          -  Subject has had a Major Depressive Episode that began no earlier than the third
             trimester and no later than the first 4 weeks following delivery, as diagnosed by the
             Structured Clinical Interview for DSM-5 Axis I Disorders (SCID-I)

          -  Subject is ≤ six months postpartum

        Key Exclusion Criteria:

          -  Active psychosis

          -  Attempted suicide associated with current episode of postpartum depression

          -  Medical history of seizures

          -  Medical history of bipolar disorder, schizophrenia, and/or schizoaffective disorder.

        Note: suicidal ideation is not an exclusion. Other protocol-defined inclusion/exclusion
        criteria may apply.
      