["parkinson's disease"]
['levodopa and carbidopa sc solution', 'oral levodopa and carbidopa']

        Inclusion Criteria:

          1. Male and female PD patients of any race aged 30 to 80 years

          2. PD diagnosis consistent with the UK PD Society Brain Bank criteria.

          3. Stable doses of anti PD drugs for at least 30 days

          4. PD patients with well-defined morning "OFF" and a good response to LD

          5. MMSE score > 26

          6. No clinically significant medical, psychiatric or laboratory abnormalities

        Exclusion Criteria:

          1. Atypical or secondary Parkinsonism.

          2. Acute psychosis or hallucinations.

          3. Subjects treated with neuroleptics

          4. History of melanoma or significant skin disorders.

          5. Prior neurosurgical procedure for PD.

          6. Patients with a history of drug abuse or alcoholism

          7. Clinically significant ECG abnormalities.

          8. Renal or liver dysfunction

          9. Subjects who have participated in another clinical study within 30 days
      