['metastatic pancreatic cancer']
['paclitaxel bound albumine']

        Inclusion Criteria:

          -  . Males or females ≥ 18 years old and ≤ 75 years old;

          -  Histological or cytological evidence of a diagnosis of pancreatic ductal
             adenocarcinoma;

          -  Written informed consent prior to any study-specific procedures; 4. Measurable
             metastatic disease, defined in according to RECIST Version 1.1 (Eisenhower et al.
             2009), that had not previously been treated with CT for metastatic disease;

          -  Eastern Cooperative Oncology Group (ECOG) performance status (PS) score of 0 or 1 ;

          -  Absence of previous abdominal radiotherapy on target lesions (except radiation therapy
             analgesic if it has not been performed on measurable targets);

          -  Absence of heart failure or angina or infarction within 12 months previous inclusion;

          -  Have adequate organ function including:

        Hematologic: absolute neutrophil count (ANC) ≥ 1.5 x 109/L, platelets ≥ 100 x 109/L.

        Hepatic: Bilirubin ≤ 1.5 times upper limits of normal (ULN) (Pts may have endoscopic or
        radiologic stenting to treat biliary obstructions).

        Renal: Serum creatinine within normal limits ≤1.5 times ULN.

        Exclusion Criteria:

          -  Age of 76 years or older;

          -  Endocrine or acinar pancreatic carcinoma;

          -  Previous radiotherapy for measurable lesions;

          -  Central nervous system metastasis;

          -  Other concomitant cancer or history of cancer outside a carcinoma in situ of the
             cervix or basal or squamous cell of the skin;

          -  Pts already included in another clinical trial with other experimental drugs;

          -  Current active infection;

          -  Have serious pre-existing medical conditions or serious concomitant systemic disorders
             that would compromise the safety of the patient or his/her ability to complete the
             study, at the discretion of the investigator (for example, unstable angina pectoris,
             or a clinically significant history of cardiac disease or uncontrolled diabetes
             mellitus);

          -  Females who are pregnant or lactating;

          -  Unable to undergo medical test for geographical, social or psychological reason

          -  Known dihydropyrimidine dehydrogenase (DPD) deficiency
      