['depressive disorder', 'depression', 'depressive disorder, major', 'mood disorders', 'mental disorders']
['placebo + adt', 'brexpiprazole +adt']

        Inclusion Criteria:

          -  Male and Female subjects between 18-65 years of age, with diagnosis of major
             depressive disorder with or without anxious distress

          -  Current depressive episode must be at least 8 weeks in duration

        Exclusion Criteria:

          -  Subjects with a history of Neuroleptic Malignant Syndrome or Serotonin Syndrome

          -  Subjects who report an inadequate response to more than 3 antidepressant treatments in
             the current episode

          -  Subjects with a current Axis I diagnosis of: Delirium, dementia, amnestic or other
             cognitive disorder, Schizophrenia, schizoaffective disorder, or other psychotic
             disorder, Bipolar I or II disorder
      