['rheumatoid arthritis']
['non-biologic dmards', 'tocilizumab', 'methotrexate']

        Inclusion Criteria:

          -  Participants with a diagnosis of active RA according to the revised (1987) ACR
             criteria or EULAR/ACR (2010) criteria.

          -  Oral corticosteroids (≤10 mg/day prednisone or equivalent), nonsteroidal
             anti-inflammatory drugs (NSAIDs) and non-biologic DMARDs are permitted if on a stable
             dose regimen for greater than or equal to (≥]) 4 weeks prior to Baseline.

          -  Use of effective contraception throughout the study as defined by protocol; female
             participants of childbearing potential cannot be pregnant.

        Exclusion Criteria:

          -  Presence of clinically significant medical conditions.

          -  History of diverticulitis, diverticulosis requiring antibiotic treatment, or chronic
             ulcerative lower gastrointestinal disease that might predispose to perforation.

          -  Current or history of recurrent bacterial, viral, fungal, mycobacterial, or other
             infections.

          -  Any infection requiring hospitalization or treatment with intravenous antibiotics
             within 4 weeks of Screening or oral antibiotics within 2 weeks of Screening.

          -  Clinically significant findings on laboratory tests.

          -  Positive hepatitis B surface antigen or hepatitis C antibody.

          -  Active tuberculosis requiring treatment within the previous 3 years.

          -  Evidence of active malignant disease, malignancies diagnosed within the previous 10
             years, or breast cancer diagnosed within the previous 20 years.

          -  History of alcohol, drug, or chemical abuse within 1 year prior to Screening.

          -  Neuropathies or other conditions that might interfere with pain evaluation.

          -  Major surgery (including joint surgery) within 8 weeks prior to Screening or planned
             major surgery within 6 months following Baseline.

          -  Rheumatic autoimmune disease other than RA, including systemic lupus erythematosis,
             mixed connective tissue disorder, scleroderma, polymyositis, or significant systemic
             involvement secondary to RA (e.g., vasculitis, pulmonary fibrosis or Felty's
             syndrome). Secondary Sjögren's syndrome with RA is permitted.

          -  Functional Class IV as defined by the ACR Classification of Functional Status in RA.

          -  Diagnosis of juvenile idiopathic arthritis or juvenile RA, and/or RA before the age of
             16 years.

          -  Prior history of or current inflammatory joint disease other than RA.

          -  Exposure to tocilizumab (either intravenous or SC) at any time prior to Baseline.

          -  Treatment with any investigational agent within 4 weeks (or five half-lives of the
             investigational drug, whichever is longer) of Screening.

          -  Previous treatment with any cell-depleting therapies, including investigational agents
             or approved therapies, with alkylating agents such as chlorambucil, or with total
             lymphoid irradiation.

          -  Treatment with IV gamma globulin, plasmapheresis within 6 months of Baseline.

          -  Immunization with a live/attenuated vaccine within 4 weeks prior to Baseline.
      