['psoriasis']
['fumaric acid']

        Inclusion Criteria:

          -  Men or women must be at least 18 years of age at the time of screening

          -  Chronic plaque-type psoriasis diagnosed for at least 6 months before randomization
             Patients with moderate to severe plaque psoriasis who are candidates for systemic
             therapy as defined at randomization by:

          -  PASI score of >10

          -  Affected body surface area (BSA) > 10%

          -  DLQI >10

          -  Inadequate response, intolerance or contraindication to topical psoriasis treatment as
             documented in the patient's medical history or reported by the patient or determined
             by the investigator at screening.

        Exclusion Criteria (abbreviated):

          -  Previous systemic treatment of plaque psoriasis or known contraindication for systemic
             therapy at baseline

          -  Ongoing use of other prohibited psoriasis and non-psoriasis treatment.

          -  Clinically important active infections or infestations, chronic, recurrent or latent
             infections or infestations

          -  Patients with severe liver diseases

          -  Patients with severe gastrointestinal diseases including but not limited to
             ventricular and duodenal ulcers

          -  Patients with severe kidney diseases or serum creatinine above 1 x ULN

          -  Patients with known hematological disease or lab abnormalities

          -  Pregnancy, breast feeding, or unwillingness/inability to use appropriate measures of
             contraception (if necessary)
      