['myeloma']
['nelfinavir', 'bortezomib', 'dexamethasone']

        Inclusion Criteria:

          -  Patient must give written informed consent prior to any protocol-specific procedure.

          -  Patient was diagnosed with multiple myeloma based on standard IMWG criteria, and has
             received at least one previous line of chemotherapy.

          -  Patient has been exposed to or is intolerant to at least one IMID (thalidomide,
             lenalidomide, pomalidomide).

          -  A therapy with bortezomib in the approved dose and schedule, based on Swissmedic
             approval (treatment of patients with relapsed/refractory multiple myeloma who have
             received at least one prior line of therapy), is indicated and intended.

          -  Patient is refractory to his/her most recent proteasome inhibitor-containing regimen,
             based on divers criteria.

          -  WHO performance status ≤ 3.

          -  Age ≥ 18 years.

          -  Adequate hematological values: platelets ≥ 50 x 109/L, hemoglobin ≥ 80 g/L (both may
             be achieved by transfusion).

          -  Adequate hepatic function: bilirubin ≤ 1.5 x ULN (for patients with suspected
             hemolysis: direct bilirubin ≤ 1.5 x ULN), ALT ≤ 3 x ULN (≤ 5 x ULN if liver
             infiltration by myeloma suspected, based on imaging results).

          -  Calculated creatinine clearance ≥ 15 mL/min, according to the formula of
             Cockcroft-Gault, see Appendix 1).

          -  Women are not breastfeeding. Women with child-bearing potential are using effective
             contraception (see 9.8), are not pregnant and agree not to become pregnant during
             participation in the trial and during the 12 months thereafter. A negative pregnancy
             test before inclusion (within 7 days) into the trial is required for all women with
             child-bearing potential. Men agree not to father a child during participation in the
             trial and during 12 months thereafter.

          -  Completed baseline QoL questionnaire.

        Exclusion Criteria:

          -  Evidence of ongoing uncontrolled systemic infections.

          -  History of chronic active HCV or HBV.

          -  Evidence of myeloma within the CNS.

          -  Psychiatric disorder precluding understanding of information on trial related topics,
             giving informed consent, filling out quality of life (QoL) forms, or interfering with
             compliance for oral drug intake.

          -  Exposure to another experimental drug within 3 weeks prior to trial entry.

          -  Any serious underlying medical condition (at the judgment of the investigator) which
             may impair the ability of the patient to participate in the trial, in particular any
             uncontrolled clinically significant active disease (e.g. active autoimmune disease,
             uncontrolled diabetes, uncontrolled cardiac disease).

          -  Non-hematologic active malignancy within the past 5 years with the exception of a)
             adequately treated basal cell carcinoma, squamous cell skin cancer, or thyroid cancer;
             b) carcinoma in situ of the cervix or breast; c) prostate cancer of Gleason Grade 6 or
             less with stable prostate-specific antigen levels; or d) cancer considered cured by
             surgical resection or unlikely to impact survival during the duration of the study,
             such as localized transitional cell carcinoma of the bladder or benign tumors of the
             adrenal or pancreas.

          -  Concomitant use of other anti-cancer medication or radiotherapy except for local pain
             control. The use of bisphosphonates is allowed.

          -  Significant neuropathy (Grades 3-4, or Grade 2 with pain) within 14 days prior to
             enrollment.

          -  Known hypersensitivity to bortezomib or nelfinavir or hypersensitivity to components
             of these drugs.

          -  Any psychological, familial, sociological or geographical condition likely hampering
             compliance with the trial protocol and follow-up.

          -  Patient who takes the following drugs during the trial therapy, which cannot be
             replaced or paused.
      