['knee osteoarthritis']
['cntx-4975-05', 'qutenza', 'lidocaine (without epinephrine)']

        Key Inclusion Criteria:

          -  Body mass index (BMI) between 18.0-35.0 kg/m^2

          -  Subject has moderate to severe painful osteoarthritis in one knee while walking (index
             knee); contralateral knee may or may not have osteoarthritis, pain should be none to
             mild in the non-index knee

          -  Confirmation of the OA of the index knee: American College of Rheumatology (ACR)
             diagnostic criteria

          -  Subject has intact skin at the location of the dosing sites (patch or injection)

        Key Exclusion Criteria:

          -  Subject has any other form of arthritis, such as, but not limited to, rheumatoid
             arthritis, psoriatic arthritis, gout, systemic lupus erythematosus, etc.

          -  Subject has a dermatological condition that may contraindicate participation,
             including any compromise in skin integrity at the CNTX-4975-05 injection site or the
             Qutenza® skin application site, e.g., severe or cystic acne, psoriasis, eczema, atopic
             dermatitis, active or treated cancer, etc.
      