
    difficulties in recruiting process
  
['dyslipidemia', 'menopause', 'obesity']
['carduus marianus 6ch', 'carduus marianus 12ch', 'carduus marianus 30ch', 'placebo']

        Inclusion Criteria:

          1. women 40-65 years in early or late transition to menopause or postmenopause according
             to STRAW classification

          2. hypertriglyceridemia [>150 <1000 mg/dL], and/or hypercholesterolemia [>200mg/dL]

          3. overweight or obesity [BMI >25 Kg/m2]

          4. fasting glucose <126mg/dL

          5. glycosylated hemoglobin <6.5%

          6. be willing and capable to follow study procedures.

        Exclusion Criteria:

          1. history of cardiovascular disease or coronary risk equivalents

          2. secondary hyperlipidemia caused by diabetes mellitus, renal, liver or thyroid diseases

          3. hypolipidemic agents, antidiabetic medication, hormone replacement therapy, tamoxifen,
             raloxifene, danazol, isotretinoin, acitretin, cyclosporin, azathioprine, protease
             inhibitors (amprenavir, indinavir, nelfinavir, ritonavir, saquinavir), antipsychotics
             (clozapine), seizure medication (carbamazepine, valproic acid, phenobarbital,
             phenytoin) either on-going or any time in the previous 2 months

          4. any other clinically significant illness that, in the opinion of the investigator,
             might put the patient at risk of harm during the study or might adversely affect the
             interpretation of the study data

          5. pregnancy or breastfeeding.
      