['diabetic kidney disease']
['tmx-049', 'placebo']

        Inclusion Criteria:

          -  Type 2 diabetes treated with ≥1 glucose-lowering medication for at least 12 months

          -  UACR 200 to 3000 mg/g

          -  eGFR ≥30 ml/min/1.73m2

          -  Treated with at least the minimal recommended dose of an angiotensin converting enzyme
             inhibitor (ACEI) or an angiotensin II receptor blocker (ARB), but not both

        Exclusion Criteria:

          -  History of Type 1 diabetes

          -  Women who are breast feeding

          -  Treatment with any uric acid-lowering therapy within previous 2 weeks

          -  History of intolerance to any XO inhibitor

          -  History of a gout flare requiring pharmacologic treatment

          -  History or presence of tophaceous gout

          -  History of immunosuppressant treatment for any known or suspected renal disorder

          -  History of a non-diabetic form of renal disease

          -  Glycosylated hemoglobin (HbA1c) >11%

          -  sUA <4.0 mg/dL or >10.0 mg/dL

          -  Positive urinary pregnancy test

          -  Dialysis for acute renal failure within previous 6 months

          -  Renal allograft in place or a scheduled kidney transplant within the next 22 weeks

          -  Congenital or acquired solitary kidney
      