['acute kidney injury']
['conestat alfa', 'sodium chloride 0.9%']

        Inclusion Criteria:

          -  Estimated glomerular filtration rate (eGFR) of <50 ml/min/1.73m2

          -  At least one of the following risk factors: diabetes mellitus, age at least 75 years,
             anemia (baseline hematocrit value less or equal 39% for men and less or equal 36% for
             women), congestive heart failure class III or IV by New York Heart Association
             classification, history of pulmonary edema.

        Exclusion Criteria:

          -  Contraindications to the class of drugs under study (C1 esterase inhibitors), e.g.
             known hypersensitivity or allergy to class of drugs or the investigational product

          -  History of allergy to rabbits

          -  Current treatment with N-acetylcysteine, sodium bicarbonate, fenoldopam, mannitol (not
             applicable to mannitol serving as excipient in other medical drugs), dopamine or
             theophylline

          -  Women who are pregnant or breast feeding

          -  Multiple myeloma

          -  Acute decompensated heart failure (requiring hospital admission and treatment with
             supplemental oxygen, diuretics and/or vasodilator therapy) within two weeks prior to
             the date of coronary angiography

          -  Acute myocardial infarction (ST elevation or non-ST elevation myocardial infarction)
             within two weeks prior to the date of coronary angiography

          -  Dialysis

          -  Exposure to iodinated contrast media within seven days prior to the date of coronary
             angiography.

          -  Participation in another study with investigational drug within the 30 days preceding
             and during the present study

          -  Previous enrolment into the current study

          -  Enrolment of the investigators and their family members
      