['leukemia, myelogenous, chronic, breakpoint cluster region-abelson proto-oncogene (bcr-abl) positive']
['bosutinib', 'imatinib']

        Inclusion Criteria:

          1. Molecular diagnosis of CP CML of ≤ 6 months (from initial diagnosis).

          2. Adequate hepatic, renal and pancreatic function.

          3. Age ≥ 18 years.

        Exclusion Criteria:

          1. Any prior medical treatment for CML, including tyrosine kinase inhibitors (TKIs), with
             the exception of hydroxyurea and/or anagrelide treatment, which are permitted for up
             to 6 months prior to study entry (signature of ICF) if suitably approved for use in
             the subject's region.

          2. Any past or current Central Nervous System (CNS) involvement, including leptomeningeal
             leukemia.

          3. Extramedullary disease only.

          4. Major surgery or radiotherapy within 14 days of randomization.

          5. History of clinically significant or uncontrolled cardiac disease.

          6. Known seropositivity to human immunodeficiency virus (HIV), current acute or chronic
             hepatitis B (hepatitis B surface-antigen positive), hepatitis C, cirrhosis or evidence
             of decompensated liver disease. Patients with resolved Hepatitis B can be included.

          7. Recent or ongoing clinically significant GI disorder, e.g. Crohn's Disease, Ulcerative
             Colitis, or prior total or partial gastrectomy.

          8. History of another malignancy within 5 years with the exception of basal cell
             carcinoma or cervical carcinoma in situ or stage 1 or 2 cancer that is considered
             adequately treated and currently in complete remission for at least l2 months.

          9. Current, or recent (within 30 days, or 5 half-lives of investigational product)
             participation in other clinical trials of investigational agents and/or containing
             interventional procedures deemed contrary to the objectives and conduct of this trial.
      