['hiv infection']
['dolutegravir', 'lamivudine', 'continue current antiretroviral regimen']

        Inclusion Criteria:

          -  HIV-1 Infection

          -  HIV-1 RNA <50 copies/mL on all measurements within 48 weeks prior to study entry while
             on any DHHS recommended or alternative three-drug antiretroviral regimen. (A history
             of switching for simplification and/or tolerability is allowed. At least two
             measurements within the previous 48 weeks are required prior to study screening.)

          -  No history of virologic failure, defined as consecutive HIV RNA > 50 copies/mL after
             12 months of initiating ART. An isolated (non-consecutive) HIV RNA > 50 copies/mL (but
             less than 400 copies/mL) is permitted after 12 months of initiating ART but not in the
             48-week window prior to study entry.

          -  Screening plasma HIV RNA < 20 copies/mL using the COBAS AmpliPrep/COBAS TaqMan HIV-1
             Test V2.0, obtained within 45 days prior to study entry

          -  Nadir CD4 count >200 cells/mm

          -  Pretreatment genotype documenting no mutations in the protease or reverse
             transcriptase genes

          -  No known resistance to integrase inhibitors

          -  Laboratory values obtained within 45 days prior to study entry:

        ANC >750 Hemoglobin >10 g/dL Platelets >50,000 Calculated creatinine clearance (CrCl) >50
        mL/min

          -  Negative serum or urine pregnancy test

          -  Men and women age greater or equal to 18 years.

          -  Ability to continue current regimen (i.e, have uninterrupted access)

          -  No evidence of chronic hepatitis B

        Exclusion Criteria:

          -  Serious illness or AIDS-related complication within 21 days of screening requiring
             systemic treatment and/or hospitalization

          -  Treatment within 30 days prior to study entry with immune modulators

          -  Vaccination within 7 days

          -  Active HCV treatment or anticipated need for treatment within study period. (HCV
             infection alone is not exclusionary)

          -  Unstable liver disease or severe hepatic impairment

          -  Known allergy or hypersensitivity to DTG or lamivudine.

          -  Active drug or alcohol use or dependence that could interfere with adherence to study
             requirements

          -  ALT (alanine aminotransferase) >5 x ULN (upper limit of normal) OR ALT >3 x ULN and
             total bilirubin >1.5 x ULN (with 35% direct bilirubin)
      