
    terminated due to futility
  
['septic shock']
['selepressin', 'placebo']

        Inclusion Criteria:

          -  18 years of age or older

          -  Proven or suspected infection

          -  Septic shock defined as hypotension requiring vasopressor treatment despite adequate
             fluid resuscitation

          -  Informed consent obtained in accordance with local regulations

        Exclusion Criteria:

          -  Not possible to initiate trial drug treatment within 12 hours from onset of
             vasopressor treatment for septic shock

          -  Primary cause of hypotension not due to sepsis

          -  Previous severe sepsis with intensive care unit admission within this hospital stay

          -  Known/suspected acute mesenteric ischaemia

          -  Suspicion of concomitant acute coronary syndrome based on clinical symptoms and/or ECG
             during this episode of septic shock

          -  Chronic mechanical ventilation for any reason OR severe chronic obstructive pulmonary
             disease (COPD) requiring either continuous daily oxygen use during the preceding 30
             days or mechanical ventilation (for acute exacerbation of COPD) during the preceding
             30 days

          -  Received bone marrow transplant during the preceding 6 months or chemotherapy during
             the preceding 30 days for lymphoma or leukemia

          -  Known to be pregnant

          -  Decision to limit full care taken before obtaining informed consent

          -  Use of vasopressin in the past 12 hours prior to start of trial drug treatment or use
             of terlipressin within 7 days prior to start of trial drug treatment

          -  Prior enrolment in the trial

          -  Prior use of an investigational medicinal product within the last month OR planned or
             concurrent participation in a clinical trial for any investigational drug or
             investigational device
      