['pulmonary disease, chronic obstructive']
['gsk2269557 100 mcg', 'gsk2269557 500 mcg', 'placebo']

        Inclusion Criteria:

          -  The subject has a confirmed and established diagnosis of COPD, as defined by the
             Global Initiative for Chronic Obstructive lung Disease (GOLD) guidelines.

          -  Male or female of non-child bearing potential between 40 and 75 years of age
             inclusive, at the time of signing the informed consent.

          -  The subject has a post-bronchodilator [400 microgram (mcg) salbutamol] Maximal amount
             of air FEV1/FVC <0.7 and FEV1 >=40% to <=80% of predicted (Predictions should be
             according to the European Community of Coal and Steel (ECCS) equations).

          -  Subject is a smoker or an ex-smoker with a smoking history of at least 10 pack years
             (pack years = (cigarettes per day smoked/20) x number of years smoked)).

          -  The subject is able to produce >100 milligram (mg) of sputum at screening.

          -  Body weight >=45 kilogram (kg) and body mass index (BMI) within the range 17 - 32
             kg/square meter (m^2) (inclusive).

          -  A female subject is eligible to participate if she is of: Non-childbearing potential
             defined as pre-menopausal females with a documented tubal ligation, hysterectomy,
             salpingo-oophrectomy or oophrectomy; or postmenopausal defined as 12 months of
             spontaneous amenorrhea [in questionable cases a blood sample with simultaneous
             follicle stimulating hormone (FSH) > 40 milli-International units (MIU)/millilitre
             (mL) and estradiol < 40 picogram (pg)/mL (<147 picomole(pmol)/Liter [L]) is
             confirmatory]. [Females on hormone replacement therapy (HRT) and whose menopausal
             status is in doubt will be required to use one of the contraception methods, if they
             wish to continue their HRT during the study. Otherwise, they must discontinue HRT to
             allow confirmation of post-menopausal status prior to study enrolment. For most forms
             of HRT, at least 2-4 weeks will elapse between the cessation of therapy and the blood
             draw; this interval depends on the type and dosage of HRT. Following confirmation of
             their post-menopausal status, they can resume use of HRT during the study without use
             of a contraceptive method.]; or has only same-sex partners, when this is her preferred
             and usual lifestyle.

          -  Male subjects with female partners of child-bearing potential must agree to use one of
             the contraception methods. This criterion must be followed from the time of the first
             dose of study medication until the follow-up visit.

          -  Based on averaged QTcF values of triplicate ECGs obtained over a brief recording
             period (e.g. 5 minutes): QTcF <450 millisecond (msec); or QTcF<480 msec in subjects
             with right bundle branch block.

          -  Capable of giving written informed consent, which includes compliance with the
             requirements and restrictions listed in the consent form.

          -  A subject with a clinical abnormality or laboratory parameter(s) which is/are not
             specifically listed in the inclusion or exclusion criteria, outside the reference
             range for the population being studied may be included if the investigator [in
             consultation with the Glaxosmithkline (GSK) medical monitor if required] documents
             that the finding is unlikely to introduce additional risk factors and will not
             interfere with the study procedures.

        Exclusion Criteria:

          -  Current or chronic history of liver disease, or known hepatic or biliary abnormalities
             (with the exception of Gilbert's syndrome, asymptomatic gallstones and
             cholecystectomy).

          -  Subjects who have a past or current medical condition or diseases that are not well
             controlled and, which as judged by the Investigator, may affect subject safety or
             influence the outcome of the study. (Note: Patients with adequately treated and well
             controlled concurrent medical conditions (e.g. hypertension) are permitted to be
             entered into the study).

          -  Subject has a diagnosis of active tuberculosis, lung cancer, clinically overt
             bronchiectasis, pulmonary fibrosis, asthma or any other respiratory condition that
             might, in the opinion of the Investigator, compromise the safety of the subject or
             affect the interpretation of the results.

          -  History of regular alcohol consumption within 6 months of the study defined as an
             average weekly intake of >28 units for males or >21 units for females. One unit is
             equivalent to 8 gram of alcohol: a half-pint (approximately 240 mL) of beer, 1 glass
             (125 mL) of wine or 1 (25 mL) measure of spirits.

          -  History of sensitivity to any of the study medications, or components (such as
             lactose) thereof or a history of drug or other allergy that, in the opinion of the
             investigator or GSK Medical Monitor, contraindicates their participation.

          -  A positive test for Human immunodeficiency virus (HIV) antibody - tested according to
             local policies.

          -  The subject has a positive pre-study drug/alcohol screen. A minimum list of drugs that
             will be screened for include cannabinoids, amphetamines, barbiturates, cocaine and
             opiates. The detection of drugs (e.g. benzodiazepines, opiates) taken for a legitimate
             medical purpose would not necessarily be an exclusion to study participation. The
             detection of alcohol would not be an exclusion at screening but would need to be
             negative pre-dose and during the study.

          -  A positive pre-study Hepatitis B surface antigen (HBs-Ag) or positive total hepatitis
             B core antibody (anti-HBc IgM) or positive Hepatitis C antibody result within 3 months
             of screening.

          -  Pregnant females as determined by positive urine human chorionic gonadotropin (hCG)
             test at screening or prior to dosing.

          -  Where participation in the study would result in donation of blood or blood products
             in excess of 500 mL within a 56 day period.

          -  Lactating females.

          -  The subject has participated in a clinical trial and has received an investigational
             product within the following time period prior to the first dosing day in the current
             study: 30 days, 5 half-lives or twice the duration of the biological effect of the
             investigational product (whichever is longer).

          -  Exposure to more than four new chemical entities within 12 months prior to the first
             dosing day.

          -  Subject has poorly controlled or unstable COPD, defined as the occurrence of any of
             the following: Either: acute worsening of COPD (an exacerbation) that is managed by
             the subject at home requiring treatment with corticosteroids and/or antibiotics in the
             4 weeks prior to the screening visit; or more than two exacerbations in the previous 2
             months prior to the screening visit that required a course of oral corticosteroids
             and/or antibiotics, or for which the subject was hospitalised.

          -  Subject has had a respiratory tract infection treated with antibiotics in the 4 weeks
             prior to first dose.

          -  Subject requires regular treatment with oral corticosteroids or has received oral or
             parenteral corticosteroids within 4 weeks of screening.

          -  Vulnerable subject (e.g., person kept in detention).

          -  The subject is not able to understand and communicate in German or native language.
      