['hepatitis c virus infection']
['simeprevir', 'sofosbuvir']

        Inclusion Criteria:

          -  Hepatitis C virus (HCV) genotype 1 infection (confirmed at screening).

          -  HCV ribonucleic acid (RNA) greater than 10,000 IU/mL at screening

          -  Treatment-experienced participants must have at least 1 documented previous course of
             interferon-based regimen with or without ribavirin

          -  Participants must have an hepatic imaging procedure (ultrasound, computerized
             tomography scan or magnetic resonance imaging scan) within 6 months prior to the
             screening visit (or between screening and Day 1) with no findings suspicious for
             hepatocellular carcinoma

          -  Participant must be willing and able to comply with the protocol requirements

          -  Participants with liver cirrhosis

        Exclusion Criteria:

          -  Evidence of clinical hepatic decompensation (history or current evidence of ascites,
             bleeding varices or hepatic encephalopathy)

          -  Infection/co-infection with HCV non-genotype 1

          -  Co-infection with human immunodeficiency virus (HIV) type 1 or type 2 (HIV-1 or HIV-2)
             (positive HIV-1 or HIV-2 antibodies test at screening)

          -  Co-infection with hepatitis B virus (hepatitis B-surface-antigen positive)

          -  Previously been treated with any direct acting anti-HCV agent (approved or
             investigational) for chronic HCV infection
      