['hypertension', 'hyperlipidemia']
['polypill (atorvastatin, amlodipine, losartan, and hydrochlorothiazide)']

        Inclusion Criteria:

          -  Enrolled at the SCCS site in Mobile, Alabama, obtain care at Franklin Primary Health
             Center, or live in the surrounding area.

          -  Aged 45-75 years

          -  Baseline systolic blood pressure ≥120 mm Hg. In this open-label trial, the study
             physicians are permitted to prescribe any additional medication deemed appropriate to
             achieve blood pressure control.

        Exclusion Criteria:

          -  History of coronary heart disease or stroke

          -  History of cancer, except for basal cell skin cancer

          -  History of liver disease, not including chronic, clinically-stable hepatitis

          -  Laboratory evidence of hepatic dysfunction (an alanine aminotransferase level more
             than two times the upper limit of the normal range)

          -  Known renal disease, estimated creatinine clearance < 60

          -  Current use of more than 2 anti-hypertensive medications

          -  LDL cholesterol ≥190 mg/dl

          -  Insulin-dependent diabetes

          -  Known intolerance to any of the components of the polypill

          -  Potassium <3.4 or >5.5 mEq/L

          -  Use of medications that interact with statins, including those affecting the
             cytochrome P450 system

          -  Current use of diuretics for indications other than hypertension

          -  Comorbidities that might be expected to limit lifespan during the 12-month follow-up
             period

          -  Inability to provide consent.
      