['end stage renal disease', 'kidney failure', 'delayed graft function', 'ischemic reperfusion injury']
['c1 esterase inhibitor', 'placebo']

        Inclusion Criteria:

          -  18-70 yrs of age; recipient of ECD/DCD/ECD&DCD with risk index 3-8 for DGF based on
             specific criteria

          -  recipient who are ABO compatible with donor allograft

          -  pretransplant with meningococcal vaccination

          -  understand and sign a written consent prior to any study specific procedure.

        Risk index (minimum 3- maximum 8):

        DGF scale: Donor Age (<40yr = 0, 41-49yr = 1, 50-54yr = 2, 55-59yr = 3, >60yr=6), Cold
        Ischemia Time (0-12= 0, 13-18=1, 19-24=2, 24-30=3, 31-36=4, >37=6; Recipient Race (nonblack
        = 0, black =1); Donor death due to Cerebrovascular Accident (CVA) (donor age <50yrs = 0,
        donor age >50yrs = 3).

        Exclusion Criteria:

          -  patients with known prothrombotic disorder (e.g. factor V leiden)

          -  history of thrombosis or hypercoagulable state excluding access clotting

          -  history of administration of C1INH containing products or recombinant C1INH within 15
             days prior to study entry

          -  patients with known contraindication to treatment with C1INH

          -  patients with abnormal coagulation function (INR >2, partial thromboplastin time (PTT)
             > 50, platelets <80,000)

          -  who are not on anti-coagulation

          -  patients with known active presence of malignancies

          -  Polymerase chain reaction (PCR) positive for hep B/hep C/or HIV

          -  preemptive kidney transplantation recipient

          -  recipients of multi-organ transplants (kidney and any other organ)

          -  recipients of kidney allograft from DD who: cold ischemia time (CIT) <18h, terminal
             serum creatinine </= 1mg/dl, recipient of kidney allograft that was on pump
             preservation for any period prior to transplantation, recipient of kidney allograft
             from a living donor, female subject who are pregnant or lactating.
      