
    slow recruitment rate
  
['diabetic retinopathy', 'posterior vitreous detachment', 'disease progression']
['ocriplasmin 0.0625mg', 'ocriplasmin 0.125mg', 'sham injection']

        Inclusion Criteria:

          -  Male or female aged 18 years or older

          -  Best-corrected visual acuity (BCVA) of 65 letters read or greater (Snellen equivalent
             of 20/50 or better) in the study eye

          -  HbA1c ≤ 12%, as assessed by the central laboratory

          -  Moderate to very severe NPDR as per ETDRS Severity Scale, based on 7 standard field
             stereo colour fundus photograph

          -  Central subfield thickness of ≤ 340µm on Spectralis SD-OCT or ≤ 320µm on
             non-Spectralis SD OCT in the study eye, with or without mild centre-involved diabetic
             macular oedema

          -  No evidence of total PVD in the study eye

          -  Written informed consent obtained from the subject prior to screening procedures

        Exclusion Criteria:

          -  History of or current ocular condition in the study eye that may interfere with the
             assessment of the progression to PDR

          -  Presence of epiretinal membrane in the study eye

          -  Presence of foveal ischemia in the study eye

          -  Presence of pre-retinal or vitreous haemorrhage in the study eye

          -  Presence of iris or angle neovascularisation in the study eye

          -  Any active ocular / intraocular infection or inflammation in either eye

          -  Aphakic study eye

          -  Uncontrolled hypertension in the opinion of the Investigator

          -  Pseudoexfoliation, Marfan's syndrome, phacodonesis or any other finding in the
             Investigator's opinion suggesting lens / zonular instability
      