["parkinson's disease"]
['irx4204']

        Inclusion Criteria:

          1. Participant is 40-80 years of age, inclusive.

          2. Participant has a clinical diagnosis of PD based on the UK Brain Bank Criteria.

          3. Participant has Hoehn and Yahr stage < 3.

          4. Participant may be treated with PD symptomatic therapy on a stable dose for at least
             30 days prior to the Screening Visit. Dose levels of PD symptomatic therapies will
             remain stable through the patient's participation in the study, unless a change of
             dose level is indicated because of adverse events.

          5. Participant must be willing and able to provide informed consent.

          6. Females must be of either non-child bearing potential based on:

               -  post-menopausal for at least 2 years, or

               -  surgically sterilized If of child bearing potential, must be neither pregnant or
                  breastfeeding at Screening, and must be willing to avoid pregnancy by using
                  medically accepted contraception (use of an intrauterine device or use of a
                  double barrier method when engaging in sexual intercourse with a male partner)
                  for 4 weeks prior to and 4 weeks following the last dose of study medication.

        Exclusion Criteria:

          1. Has any form of parkinsonism other than idiopathic PD

          2. Are currently experiencing motor fluctuations (end of dose wearing off or dyskinesias)
             reflective of later stage PD

          3. Has evidence of dementia or significant cognitive dysfunction

          4. Has clinically significant abnormal laboratory value and/or clinically significant
             unstable medical or psychiatric illness.

          5. The subject has any disorder that may interfere with drug absorption, distribution,
             metabolism or excretion.

          6. The subject has evidence of clinically significant gastrointestinal, cardiovascular,
             hepatic, renal, hematological, neoplastic, endocrine, alternative neurological,
             immunodeficiency, pulmonary, or other disorder or disease.

          7. Pregnancy or breastfeeding
      