['constipation predominant irritable bowel syndrome']
['tenapanor']

        Inclusion Criteria:

          -  Subjects completed all 16 weeks of TEN-01-301 or all 26 weeks of TEN-01-302

          -  Subject demonstrated adequate compliance with the study procedures during either the
             TEN-01-301 or TEN-01-302 studies

          -  Females must be of non-childbearing potential; If of child-bearing potential, must
             have negative pregnancy test and confirm the use of one of the appropriate means of
             contraception

          -  Males must agree to use appropriate methods of barrier contraception or have
             documented surgical sterilization

        Exclusion Criteria:

          -  Subject has been withdrawn or discontinued prematurely from either TEN-01-301 or
             TEN-01-302

          -  The subject reports using any prohibited medication and is not willing to abide by the
             restrictions for intake

          -  Pregnant or lactating women
      