['advanced solid tumors']
['tas-102']

        Inclusion

          1. Has provided written informed consent

          2. Has advanced solid tumors (excluding breast cancer)

          3. Has normal hepatic function, mild, moderate, or severe hepatic impairment

          4. ECOG performance status of ≤2

          5. Is able to take medications orally

          6. Has adequate organ function

          7. Women of childbearing potential must have a negative pregnancy test and must agree to
             adequate birth control if conception is possible. Males must agree to adequate birth
             control.

        Exclusion

          1. Certain serious illnesses or medical condition(s)

          2. Has had certain other recent treatment e.g. major surgery, anticancer therapy,
             extended field radiation, received investigational agent, shunt in the liver within
             the specified time frames prior to study drug administration

          3. Has received TAS-102

          4. Has unresolved toxicity of greater than or equal to CTCAE Grade 2 attributed to any
             prior therapies

          5. Is a pregnant or lactating female
      