
    major challenge for enrollment of participants.
  
['non-small cell lung cancer']
['inc280 single agent', 'erlotinib']

        Inclusion Criteria:

          -  Locally advanced or metastatic NSCLC

          -  EGFR mutation (L858R and /or ex19del)

          -  cMET amplification by FISH (GCN ≥ 6),

          -  Acquired resistance to EGFR TKI (1st or 2nd generation)

          -  ECOG performance status (PS) ≤ 1.

        Exclusion Criteria:

          -  Prior treatment with 3rd generation TKI

          -  PhaseII : Prior treatment with any of the following agents:

               -  Crizotinib, or any other cMET inhibitor or HGF-targeting inhibitor.

               -  Concomitant EGFR TKI and platinum based chemotherapy as first line regimen.

               -  Platinum-based chemotherapy as first line treatment
      