
    suspended to accrual due to covid-19
  
['clostridium difficile infection recurrence']
['fmt oral capsule', 'oral vancomycin', 'fmt oral placebo', 'oral vancomycin placebo']

        Inclusion Criteria:

          -  Is able to provide written informed consent

          -  Is willling to comply with all study procedures and be available for study duration

          -  Can take oral medication

          -  Is a solid organ transplant (SOT) recipient

          -  Has had at recurrent C. difficile infection defined as: positive C. difficile testing
             in stool and diarrhea (three or more loose stools over 24 hours) during the 180 day
             period following completion of treatment for prior episode.

          -  History of positive IgG test (patient or organ donor) to cytomegalovirus (CMV) and
             Epstein-Barr Virus (EBV)

          -  Negative urine or serum pregnancy test for women of childbearing potential and agree
             to use effective form of contraception until 6 weeks post treatment

          -  Clinical response to 4-7 days of oral antibiotic standard of care treatment for the
             current episode of CDI. Clinical response is defined as greater than or equal to 25%
             reduction of diarrhea.

        Exclusion Criteria:

          -  Active intestinal disease (e.g. Crohn's disease, ulcerative colitis)

          -  Major bowel resection surgery within 90 days of randomization

          -  Known or suspected toxic megacolon and/or small bowel ileus

          -  History of total colectomy or bariatric surgery

          -  Dysphagia; oropharyngeal, S), or patient has evidence of dysphagia when the 'safety
             test' capsule is administered.

          -  Neutropenia, ≤ 500 neutrophils/ml [noted in medical records and resulted within 30
             days of Visit 1]).

          -  Expected life expectancy is less than 6 months.

          -  Is taking concomitant antibiotics within 48 hours of Visit 2. Topical antibiotics,
             antibiotics - for transplant prophylaxis, and C. difficile antibiotic treatment
             antibiotics are permitted.

          -  Unwilling to withhold probiotics. Probiotics include supplements, prescriptions, and
             non-prescriptions. Foods (like yogurt) are not prohibited

          -  Concurrent intensive induction chemotherapy, radiation therapy or biological treatment
             for any active malignancy. Patients on maintenance chemotherapy could be enrolled
             after consultation with the study Medical Monitor.

          -  Any severe food allergy, defined as a history of anaphylaxis, systemic urticarial or
             angioedema attributed to a food and requiring current avoidance precautions.

          -  Gastroparesis.

          -  Symptomatic co-infection with another intestinal pathogen as determined by chart
             review.

          -  Women who are pregnant, lactating or planning on becoming pregnant during the study.

          -  Not suitable for study participation due to other reasons at the discretion of the
             investigators.
      