['germline brca1/2 mutations and', 'metastatic adenocarcinoma of the pancreas']
['olaparib', 'olaparib', 'placebo', 'placebo']

        Key Inclusion Criteria

          -  Histologically or cytologically confirmed pancreas adenocarcinoma receiving initial
             chemotherapy for metastatic disease and without evidence of disease progression on
             treatment

          -  Patients with measurable disease and/or non-measurable or no evidence of disease
             assessed at baseline by CT (or MRI where CT is contraindicated) will be entered in
             this study.

          -  Documented mutation in gBRCA1 or gBRCA2 that is predicted to be deleterious or
             suspected deleterious

          -  Patients are on treatment with a first line platinum-based (cisplatin, carboplatin or
             oxaliplatin) regimen for metastatic pancreas cancer, have received a minimum of 16
             weeks of continuous platinum treatment and have no evidence of progression based on
             investigator's opinion.

          -  Patients who have received platinum as potentially curative treatment for a prior
             cancer (eg ovarian cancer) or as adjuvant/neoadjuvant treatment for pancreas cancer
             are eligible provided at least 12 months have elapsed between the last dose of
             platinum-based treatment and initiation of the platinum-based chemotherapy for
             metastatic pancreas cancer.

        Major Exclusion Criteria:

          -  gBRCA1 and/or gBRCA2 mutations that are considered to be non detrimental (eg,
             "Variants of uncertain clinical significance" or "Variant of unknown significance" or
             "Variant, favour polymorphism" or "benign polymorphism" etc.)

          -  Progression of tumour between start of first line platinum based chemotherapy for
             metastatic pancreas cancer and randomisation.

          -  Cytotoxic chemotherapy or non-hormonal targeted therapy within 28 days of Cycle

             1 Day 1 is not permitted.

          -  Exposure to an investigational product within 30 days or 5 half lives (whichever is
             longer) prior to randomisation

          -  Any previous treatment with a PARP inhibitor, including Olaparib
      