['major depressive disorder']
['diprivan']

        Inclusion Criteria:

          -  • Diagnosis of Major Depressive Disorder (MDD) or bipolar Disorder (I or II, most
             recent episode must be depression

               -  Failed at least 2 anti-depressant treatments and no ECT in past 6 months

               -  Age between 18-55 years

               -  BMI < 35

               -  Hamilton Rating Scale for Depression (HSRD) score > 18

               -  Quick Inventory of Depression Scale (QIDS) score > 10.

        Exclusion Criteria:

          -  • Diagnosis of primary psychotic disorder, dysthymia, or personality disorder

               -  Significant pre-morbid cognitive impairment

               -  Hypertension and current use of ACE inhibitor or AR blocker medications

               -  Symptomatic coronary artery disease or congestive heart failure

               -  History of transient ischemic or neurologic signs during the past year

               -  History of or susceptibility to malignant hyperthermia

               -  Contraindication to isoflurane or propofol anesthesia (as determined by
                  anesthesiologist)

               -  Diabetes requiring insulin

               -  Poor kidney function

               -  Chronic use of benzodiazepines or opioids

               -  Individuals incompetent to provide consent (e.g. catatonic, psychotic).
      