['hiv', 'pregnancy']
['dolutegravir 50mg od', 'standard of care']

        Inclusion Criteria:

          -  Able to provide informed consent

          -  Willing to participate,

          -  Women age 18 years and above

          -  Pregnant

          -  Untreated HIV infection in late pregnancy at ≥28 - 36 weeks gestation

        Exclusion Criteria:

          -  Received antiretroviral drugs in previous 6 months

          -  Ever received integrase inhibitors

          -  Serum haemoglobin < 8.0 g/dl

          -  Elevations in serum levels of alanine aminotransferase (ALT) >5 times the upper limit
             of normal (ULN) or ALT >3xULN and bilirubin >2xULN (with >35% direct bilirubin)

          -  eGFR < 50ml/min

          -  Active Hepatitis B infection, history or clinical suspicion of unstable liver disease,
             or subjects with severe liver disease (Class C by Childs-Hugh criteria)

          -  Severe pre-eclampsia (e.g. HELLP), or other pregnancy related events such as renal or
             liver abnormalities (e.g. grade 2 or above proteinuria, elevation in serum creatinine
             (above 2.5 x ULN), total bilirubin ALT or AST)

          -  Paternal non-consent (where disclosure to male partner has been made)

          -  Clinical depression or clinical judgement suggests increased risk of suicidality
      