['pre-exposure prophylaxis of hiv-1 infection']
['f/taf', 'f/tdf', 'f/taf placebo', 'f/tdf placebo']

        Key Inclusion Criteria:

          -  Must be at high risk of sexual acquisition of HIV

          -  HIV-1 negative status

          -  MSM and TGW (male at birth) who have at least one of the following:

               -  condomless anal intercourse with at least two unique male partners in the past 12
                  weeks (partners must be either HIV-infected or of unknown HIV status)

               -  documented history of syphilis in the past 24 weeks

               -  documented history of rectal gonorrhea or chlamydia in the past 24 weeks

          -  Adequate renal function: estimated glomerular filtration rate ≥ 60 mL/min according to
             the Cockcroft-Gault formula

          -  Adequate liver and hematologic function:

               -  Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) ≤ 2.5 × upper
                  limit of normal (ULN) and total bilirubin ≤ 1.5 mg/dL, or normal direct bilirubin

               -  Absolute neutrophil count ≥ 1000/mm^3; platelets ≥ 75,000/mm^3; hemoglobin ≥ 10
                  g/dL

        Key Exclusion Criteria

          -  Grade 3 or Grade 4 proteinuria or glycosuria that is unexplained or not clinically
             manageable.

        NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.
      