['bronchiolitis']
['nitric oxide']

        Inclusion Criteria:

          1. 1. Pediatric subjects 0-12-months old.

             a. Including subjects born at ≥28 weeks of gestation.

          2. Subjects with acute bronchiolitis requiring in-patient hospitalization expected for 24
             hours and more.

          3. Clinical score of between 7 to 10 at Screening (without oxygen supplementation).

          4. Parent/guardian who is willing and able to sign, an informed consent on behalf of the
             subject.

        Exclusion Criteria:

          1. 1. Subjects diagnosed with alveolar pneumonia on Chest X-ray (including WBC≥
             15,000/ul, and Temp >39°C).

          2. Previous diagnosis of asthma or requirement for asthma medications.

          3. Subjects with >2 previous wheezing episodes.

          4. History of life-threatening respiratory distress that requires admission to an
             intensive care unit for treatment.

          5. Subjects with history of methemoglobinemia and/or methemoglobin >5% for any cause.

          6. Use of an investigational drug within 30 days before enrolment and/or expected to
             participate in a new study within 90 days.

          7. History of frequent epistaxis (>1 episode/month) or significant hemoptysis within 30
             days prior to enrolment (≥5 mL of blood in one coughing episode or >30 mL of blood in
             a 24-hour period.

          8. Taken medications such as chronic systemic corticosteroids, CNS stimulants,
             theophylline or aminophylline, anti-arrhythmic within a certain time period prior to
             the study.

          9. Unable to comply with the study procedures.

         10. Underlying genetic disorders (including Cystic fibrosis) or hypotonia.

         11. Having the following signs or symptoms: 1) known pulmonary (lung) and/or cardiac
             (heart) congenital malformations 2) an underlying renal, or liver insufficiency,
             immunodeficiency, encephalopathy; 3) known or suspected foreign body aspiration.

         12. Any reason that, in the opinion of the investigator, may make the subject unfit for
             this clinical trial.
      