['pre-hypertension', 'jnc 7 stage i hypertension']
['allopurinol', 'placebo']

        Inclusion Criteria:

          -  Pre-hypertension or stage I hypertension, defined as the following after the mean of
             two clinic measurements:

          -  Systolic blood pressure (SBP) ≥ 120 and <160 or;

          -  Diastolic blood pressure (DBP) ≥ 80 and < 100

          -  Serum urate ≥ 5.0 mg/dL for men or ≥ 4.0 mg/dL for women

          -  Age 18-40

        Exclusion Criteria:

          -  Any current pharmacological treatment for hypertension, including diuretics (calcium
             channel blockers at stable doses were later allowed)

          -  Estimated glomerular filtration rate < 60 mL/min/1.73m2

          -  Current use of any urate-lowering therapy or statins

          -  Prior diagnosis of gout or past use of urate-lowering therapy for gout

          -  Prior diagnosis of diabetes

          -  Pregnancy, or recent delivery or last trimester pregnancy loss more recent than 3
             months

          -  Active smokers

          -  Immune-suppressed individuals including transplant recipients or current use of
             azathioprine.

          -  Leucopenia with absolute white cell count < 3000 /mL, anemia with hemoglobin < 12
             g/dL, or thrombocytopenia with platelet count < 150,000/mL

          -  Individuals of Han Chinese or Thai descent with HLAB5801 genetic phenotype

          -  Serious medical condition that at investigator's judgment precludes utilization of a
             fixed dose of allopurinol
      