
    the study was terminated early due to pre-clinical toxicity data that became available after
    start of trial
  
['post-herpetic neuralgia']
['ema401', 'placebo']

        Inclusion Criteria:

          -  At the time of Screening, must have had documented diagnosis of PHN (ICD-10 code
             B02.29), defined as pain in the region of the rash persisting for more than 6 months
             after onset of herpes zoster rash.

          -  Assessed as suffering from moderate to severe neuropathic pain across the Screening
             epoch (NRS ≥ 4).

          -  Patients must have had documented past and/or ongoing inadequate treatment response
             (having insufficient pain relief with treatment or inability to tolerate) to at least
             2 different prescribed therapies commonly used to treat and considered effective by
             the Investigator for the treatment of PHN.

          -  Patient must have been willing to complete daily eDiary

        Exclusion Criteria:

          -  History or had current diagnosis of electrocardiogram (ECG) abnormalities indicating
             significant risk of safety for patients participating in the study

          -  Had a major depressive episode within 6 months prior to Screening and/or a history of
             diagnosed recurrent major depressive disorder according to Diagnostic and Statistical
             Manual of Mental Disorders, 5th Edition (DSM-V) diagnostic criteria

          -  Women of child-bearing potential, defined as all women physiologically capable of
             becoming pregnant.

          -  Had evidence of significant renal insufficiency or pre-existing liver condition

          -  Had platelets ≤ 100 x 10^9/L, or neutrophil count < 1.2 x 10^9/L (or equivalent),
             hemoglobin ≤ 100 g/L for women or hemoglobin ≤ 110 g/L for men.

          -  Patients who had a known diagnosis of diabetes and are stable on medication with a
             hemoglobin A1c > 8%. Those who did not have a known diagnosis of diabetes with a
             hemoglobin A1c > 7%.
      