['ccnd1 gene amplification', 'ccnd2 gene amplification', 'ccnd3 gene amplification', 'cdk4 gene amplification', 'recurrent squamous cell lung carcinoma', 'stage iv squamous cell lung carcinoma ajcc v7']
['docetaxel', 'palbociclib']

        Inclusion Criteria:

          -  Patients must meet all SCREENING/PRE-SCREENING and SUB-STUDY REGISTRATION COMMON
             ELIGIBILITY CRITERIA as specified in S1400: Phase II/III Biomarker-Driven Master
             Protocol for Previously Treated Squamous Cell Lung Cancer (Lung-Map)

          -  Patients must be assigned to S1400C

          -  Patients must not be taking within 7 days prior to sub-study registration, nor plan to
             take while on protocol treatment and for 14 days after the last dose of study
             treatment, strong CYP3A4 inhibitors and/or strong CYP3A4 inducers; moderate inhibitors
             or inducers of isoenzyme CYP3A4 should be avoided, but if necessary can be used with
             caution

          -  Patients must not be taking within 7 days prior to sub-study registration, nor plan to
             take while on protocol treatment drugs that are known to prolong the QT interval

          -  Patients must not have a screening corrected QT Fridericia?s formula (QTcF) interval >
             480 msec based on the average of the triplicate electrocardiograms (EKGs) performed
             within 28 days prior to registration; NOTE: triplicate EKGs are required at other
             timepoints; patients must not have any family or personal history of long or short QT
             syndrome, Brugada syndrome or known history of QTc prolongation, or torsade de pointes

          -  Patients must be able to take oral medications; patient may not have any impairment of
             gastrointestinal function or gastrointestinal disease that may significantly alter the
             absorption of palbociclib (e.g. ulcerative disease, uncontrolled nausea, vomiting,
             diarrhea, malabsorption syndrome or small bowel resection)

          -  Patients must have a sodium (Na), potassium (K), chlorine (Cl), calcium (Ca),
             magnesium (Mg), and glycosylated hemoglobin measurement (HbA1c) performed within 7
             days prior to sub-study registration

          -  Patients must also be offered participation in banking for future use of specimens

          -  STEP 2 PALBOCICLIB RE-REGISTRATION:

          -  Patients must have progressed on Arm 2 (docetaxel) of this sub-study

          -  Patients must not have received any prior systemic therapy (systemic chemotherapy,
             immunotherapy or investigational drug) within 21 days prior to step 2 re-registration;
             patients must have recovered (< grade 1) from any side effects of prior therapy

          -  Patients must have measurable disease documented by computed tomography (CT) or
             magnetic resonance imaging (MRI); the CT from a combined positron emission tomography
             (PET)/CT may be used to document only non-measurable disease unless it is of
             diagnostic quality; measurable disease must be assessed within 28 days prior to step 2
             re-registration; pleural effusions, ascites and laboratory parameters are not
             acceptable as the only evidence of disease; non-measurable disease must be assessed
             within 42 days prior to step 2 re-registration; all disease must be assessed and
             documented on the Baseline Tumor Assessment Form; patients whose only measurable
             disease is within a previous radiation therapy port must demonstrate clearly
             progressive disease (in the opinion of the treating investigator) prior to
             registration

          -  Patients must have a CT or MRI scan of the brain to evaluate for central nervous
             system (CNS) disease within 42 days prior to step 2 re-registration; patient must not
             have leptomeningeal disease, spinal cord compression or brain metastases unless: (1)
             metastases have been locally treated and have remained clinically controlled and
             asymptomatic for at least 14 days following treatment and prior to re-registration,
             AND (2) patient has no residual neurological dysfunction and has been off
             corticosteroids for at least 24 hours prior to re-registration

          -  Patients must not be planning to receive any concurrent chemotherapy, immunotherapy,
             biologic or hormonal therapy for cancer treatment; concurrent use of hormones for
             non-cancer-related conditions (e.g., insulin for diabetes and hormone replacement
             therapy) is acceptable

          -  Patients must not have a screening QTcF interval > 480 msec based on the average of
             the triplicate EKGs performed within 28 days prior to step 2 re-registration; NOTE:
             triplicate EKGs are required at other timepoints; patients must not have any family or
             personal history of long or short QT syndrome, Brugada syndrome or known history of
             QTc prolongation, or torsade de pointes

          -  Absolute neutrophil count (ANC) >= 1,500/mcl obtained within 28 days prior to step 2
             re-registration

          -  Platelet count >= 100,000 mcl obtained within 28 days prior to step 2 re-registration

          -  Hemoglobin >= 9 g/dL obtained within 28 days prior to step 2 re-registration

          -  Serum bilirubin =< institutional upper limit of normal (IULN); for patients with liver
             metastases, bilirubin must be =< 5 x IULN within 28 days prior to step 2
             re-registration

          -  Either alanine aminotransferase (ALT) or aspartate aminotransferase (AST) =< 2 x IULN
             within 28 days prior to step 2 re-registration (if both ALT and AST are done, both
             must be < 2 IULN); for patients with liver metastases, either ALT or AST must be =< 5
             x IULN (if both ALT and AST are done, both must be =< 5 x IULN)

          -  Patients must have a serum creatinine =< the IULN OR measured or calculated creatinine
             clearance >= 50 mL/min

          -  Patients must have a Na, K, Cl, Ca, Mg, and HbA1c performed within 7 days prior to
             sub-study registration

          -  Patients must have Zubrod performance status of 0-1 documented within 28 days prior to
             step 2 re-registration

          -  Patients must not have any grade III/IV cardiac disease as defined by the New York
             Heart Association Criteria (i.e., patients with cardiac disease resulting in marked
             limitation of physical activity or resulting in inability to carry on any physical
             activity without discomfort), unstable angina pectoris, and myocardial infarction
             within 6 months, or serious uncontrolled cardiac arrhythmia

          -  Patients must not have documented evidence of acute hepatitis or have an active or
             uncontrolled infection

          -  Patients with a known history of human immunodeficiency virus (HIV) seropositivity:

               -  Must have undetectable viral load using standard HIV assays in clinical practice

               -  Must have cluster of differentiation (CD)4 count >= 400/mcL

               -  Must not require prophylaxis for any opportunistic infections (i.e., fungal,
                  mycobacterium avium complex [mAC], or pneumocystis pneumonia [PCP] prophylaxis)

               -  Must not be newly diagnosed within 12 months prior to re-registration

          -  Pre-study history and physical exam must be obtained within 28 days prior to
             re-registration

          -  No other prior malignancy is allowed except for the following: adequately treated
             basal cell or squamous cell skin cancer, in situ cervical cancer, adequately treated
             stage I or II cancer from which the patient is currently in complete remission, or any
             other cancer from which the patient has been disease free for five years

          -  Patients must not be pregnant or nursing; women/men of reproductive potential must
             have agreed to use an effective contraceptive method; a woman is considered to be of
             "reproductive potential" if she has had menses at any time in the preceding 12
             consecutive months; in addition to routine contraceptive methods, "effective
             contraception" also includes heterosexual celibacy and surgery intended to prevent
             pregnancy (or with a side-effect of pregnancy prevention) defined as a hysterectomy,
             bilateral oophorectomy or bilateral tubal ligation; however, if at any point a
             previously celibate patient chooses to become heterosexually active during the time
             period for use of contraceptive measures outlined in the protocol, he/she is
             responsible for beginning contraceptive measures

          -  As a part of the Oncology Patient Enrollment Network (OPEN) registration process the
             treating institution's identity is provided in order to ensure that the current
             (within 365 days) date of institutional review board approval for this study has been
             entered in the system

          -  Patients with impaired decision-making capacity are eligible as long as their
             neurological or psychological condition does not preclude their safe participation in
             the study (e.g., tracking pill consumption and reporting adverse events to the
             investigator)

          -  Patients must be informed of the investigational nature of this study and must sign
             and give written informed consent in accordance with institutional and federal
             guidelines
      