
    the target cannot be achieved within timeline due to delay of ethics approval
  
['bacteremia', 'healthcare-associated pneumonia', 'ventilator-associated pneumonia']
['polymyxin b', 'polymyxin b + doripenem']

        Inclusion Criteria:

          -  Monomicrobial XDR-GNB bacteremia.

          -  Monomicrobial XDR-GNB ventilator-associated pneumonia OR healthcare-associated
             pneumonia.

        Exclusion Criteria (will be excluded if subjects meet one or more of the following
        criteria):

          -  Allergy to any of the study medications.

          -  For female patients, the patients is pregnant.

          -  Unable to provide consent and have no legally authorized representatives.

          -  Currently enrolled in another trial.

          -  >48 hours after XDR-GNB confirmation by the microbiology laboratory.

          -  Palliative care or with less than 24 hours of life expectancy, as discussed with their
             primary physicians.

          -  Co-infection with other aerobic Gram-negative bacteria.

          -  Severe renal impairment (creatinine clearance <30 milliliters (mL)/min).

               -  Concurrent infection not involving the lungs or bloodstream is not an exclusion
                  criterion for the study.
      