
    the overall benefit-risk profile did not support continued development of ly2409021 for type 2
    diabetes.
  
['diabetes mellitus, type 2']
['ly2409021', 'sitagliptin', 'placebo', 'metformin', 'sulfonylurea']

        Inclusion Criteria:

          -  Have been treated with a stable dose of metformin for at least 3 months and have been
             treated with an optimally effective and stable dose of an sulfonylurea for at least 6
             months prior to screening.

          -  HbA1c value between 7.0% and 10.0%, inclusive.

          -  Body mass index (BMI) between 20 and 45 kilograms/square meter (kg/m^2), inclusive.

        Exclusion Criteria:

          -  Known type 1 diabetes mellitus.

          -  More than 1 episode of severe hypoglycemia within 6 months prior to screening.

          -  Two or more emergency room visits or hospitalizations due to poor glucose control in
             the 6 months prior to screening.

          -  Severe gastrointestinal disease that may significantly impact gastric emptying or
             motility or having undergone gastric bypass or gastric banding surgery.

          -  Previous history or active diagnosis of pancreatitis.

          -  Positive hepatitis B surface antigen or hepatitis C antibody.

          -  Clinical signs or symptoms of liver disease, or hepatic aminotransferases
             (aminotransferase or alanine aminotransferase) greater than 2.0× upper limit of normal
             (ULN) or elevated alkaline phosphatase (greater than ULN) unrelated to bone metabolic
             disease.

          -  Elevated total bilirubin level (greater than ULN), clinically suspicious
             signs/symptoms of cirrhosis or history of cirrhosis.

          -  Current diagnosis, personal history of neuroendocrine tumors, family history of any
             type of multiple endocrine neoplasia (MEN), or Von Hippel-Lindau.

          -  Contraindications for magnetic resonance imaging.
      