['major depressive disorder']
['alks 5461']

        Inclusion Criteria:

          -  Agree to use an approved method of contraception for the duration of the study

          -  Have the potential to safely benefit from the administration of ALKS 5461

          -  Have a diagnosis of major depressive disorder (MDD)

          -  Additional criteria may apply

        Exclusion Criteria:

          -  Have a positive test for drugs of abuse

          -  Currently pregnant or breastfeeding

          -  Have a current primary Axis-I disorder other than MDD

          -  Have used opioid agonists (eg, codeine, oxycodone, tramadol, morphine) or opioid
             antagonists (eg, naloxone, naltrexone) within 14 days

          -  Have received electroconvulsive therapy treatment within the last 2 years, or received
             more than 1 course of electroconvulsive treatment during their lifetime

          -  Have attempted suicide within the past 2 years

          -  Have a history of intolerance, allergy, or hypersensitivity to buprenorphine or opioid
             antagonists (eg, naltrexone, naloxone)

          -  Have had a significant blood loss or blood donation within the past 60 days

          -  Additional criteria may apply
      