
    very poor recruitment in the part 4 of the study
  
['chronic obstructive pulmonary disease']
['chf6297 (part 1 - sad)', 'placebo (part 1 - sad)', 'chf6297 (part 2 - mad)', 'placebo (part 2 - mad)', 'chf6297 (part 3)', 'placebo (part 3)', 'chf6297 (part 4)', 'placebo (part 4)']

        Inclusion criteria:

        Part 1, Part 2, Part 4 (Healthy subjects):

          -  Male subjects aged 18-55 years;

          -  Non smokers

          -  Lung function above 80% of predicted normal value

          -  Healthy subjects based on medical evaluation including medical history, physical
             examination, laboratory tests and cardiac testing

          -  ability to produce an adequate induced sputum sample (study part 4 only)

        Part 3 (COPD patients):

          -  Males and females aged 40-75 years

          -  Current or past smokers

          -  stable patients with a post-bronchodilator FEV1 between 40 and 80% of predicted normal
             value and FEV1/FVC ratio <0.7

          -  Ability to produce a spontaneous and an adequate induced sputum sample

        Exclusion Criteria:

        Parts 1,2, 4 (Healthy subjects):

          -  Any clinically relevant abnormalities and/or uncontrolled diseases

          -  Abnormal laboratory values

          -  Recent respiratory tract infection

          -  Hypersensitivity to the drug or excipients

          -  Positive serology results

          -  Positive cotinine, alcohol, drug of abuse tests

        Part 3 (COPD patients):

          -  Females of childbearing potential

          -  History of asthma

          -  Unstable concomitant diseases

          -  Abnormal relevant Holter ECG parameters

          -  Recent acute exacerbations of COPD or respiratory tract infection

          -  Hypersensitivity to the drug or excipients

          -  Positive serology results
      