['neoplasm metastasis']
['ds-8201a', 'ritonavir', 'itraconazole']

        Inclusion Criteria:

          -  Has a pathologically documented unresectable or metastatic solid malignant tumor, with
             HER2 expression [immunohistochemistry (IHC) 3+, 2+, or 1+ and/or in situ hybridization
             (ISH) +], Next Generation Sequencing, or other analysis techniques as appropriate]
             that is refractory to or intolerable with at least one prior systemic chemotherapy
             regimen, or for which no standard treatment is available

          -  Has a left ventricular ejection fraction (LVEF) ≥ 50%

          -  Has an Eastern Cooperative Oncology Group performance status (ECOG PS) score of 0 or 1

        Exclusion Criteria:

          -  Has a contraindication for receiving ritonavir or itraconazole according to the
             prescribing information

          -  Has a medical history of myocardial infarction within 6 months before enrollment or
             symptomatic congestive heart failure
      