
    pi decision due to slow accrual
  
['perfusion; complications']
['nitroglycerin']

        Inclusion Criteria:

          -  Patients must be female.

          -  Patients must be between the ages of 18 and 99 years.

          -  Patients must undergo mastectomy with our attending breast oncology surgeons followed
             by possible implant-based immediate breast reconstruction (IBR) performed by our
             attending plastic surgeons at WFBMC.

          -  Patients must have the ability to understand and the willingness to sign an
             IRB-approved informed consent document.

        Exclusion Criteria:

          -  Patients who are under the age of 18 or over the age of 99.

          -  Patients who are undergoing mastectomy without immediate breast reconstruction
             including immediate breast reconstruction with autologous tissue (or combination of
             autologous tissue with tissue expanders or implants), or patients with a history of
             mastectomy presenting for delayed breast reconstruction.

          -  Patients with pre-existing conditions in which use of indocyanine-green is
             contraindicated or must be used with caution, including those with a history of
             allergy to iodides or iodinated dye, those with chronic kidney disease, those with
             hepatic failure or cirrhosis of the liver, and females who are nursing, pregnant, or
             may become pregnant.

          -  Pregnant women are excluded from this study because pregnancy precludes immediate
             breast reconstruction in our patient population.

          -  Patients with pre-existing conditions in which use of nitroglycerin paste is
             contraindicated, including those with a history of cardiac insufficiency, hypotension,
             sensitivity to nitrites, severe liver impairment, glaucoma, hyperthyroidism, recent
             head trauma, severe anemia, or taking certain medication (i.e. alteplase, aspirin,
             beta-blocker, calcium channel blocker, diuretics or thiazides).

          -  Patients with pre-existing conditions in whom use of incisional negative pressure
             wound therapy is contraindicated including those with evidence of surgical site
             infection ( i.e. erythema, purulent drainage), clinical signs of hematoma (i.e. wound
             swelling, fluctuance, blood drainage), history of persistent cancer, exposed blood
             vessel on site of proposed therapeutic use, or sensitivity to acrylics and adhesives.
      