['dry eye syndrome']
['top1630 ophthalmic solution', 'placebo to top1630 ophthalmic solution']

        Inclusion Criteria:

          -  Be at least 18 years of age;

          -  Provide written informed consent;

          -  Have a reported history of dry eye;

          -  Have a history of use of eye drops for dry eye symptoms;

        Additionally for Part 2

        Symptoms of dry eye syndrome including:

          -  Ocular discomfort

          -  Conjunctival redness

          -  Tear film break up time

          -  Schirmer test score

        Signs of dry eye syndrome including:

        Conjunctival staining score

        Exclusion Criteria:

          -  Have any clinically significant slit lamp findings at entry visit ;

          -  Be diagnosed with an ongoing ocular infection;

          -  Have any significant ocular lesion that could interfere with assessment of safety or
             efficacy or prevent study conduct in the opinion of the PI;

          -  Have any planned ocular and/or lid surgeries over the study period;

          -  Have an uncontrolled systemic disease;

          -  Be a woman who is pregnant, nursing or planning a pregnancy;

          -  Be a woman of childbearing potential who is not using an acceptable means of birth
             control;

          -  Have a known allergy and/or sensitivity to the test article or its components;

          -  Have a condition or be in a situation which the investigator feels may put the subject
             at significant risk, may confound the study results, or may interfere significantly
             with the subject's participation in the study;
      