
    insufficient accrual
  
['hemoglobin sc disease']
['hydroxyurea']

        Inclusion Criteria:

          -  Diagnosis of HbSC disease

          -  Score of 80 or lower on the AdultQLTM 3.0 Sickle Cell Disease Module, or any disease
             related complication, including, but not limited to, one or more pain events per year,
             proliferative sickle retinopathy, avascular necrosis, cholelithiasis, or any
             thrombotic event. If the subject has a score >80, they may still enroll on the trial,
             and be analyzed for secondary endpoints. They will be excluded from analysis of the
             primary endpoint.

        Exclusion Criteria:

          -  Failure to meet inclusion criteria

          -  Hydroxyurea usage in the last 3 months.

          -  Chronic RBC transfusion therapy

          -  Packed red blood cell transfusion in the last 3 months (temporary exclusion).

          -  Pregnancy, or refusal to use medically effective birth control if female and sexually
             active.

          -  Current phlebotomy therapy
      