['depressive disorder, major']
['normal saline']

        Inclusion Criteria:

          -  Moderate to severe major depressive disorder

        Exclusion Criteria:

          -  Prior treatment with botulinum toxin of any serotype for any reason

          -  Use of antidepressant medication for depression within 2 weeks of study

          -  Diagnosis of Myasthenia gravis, Eaton-Lambert Syndrome, Amyotrophic Lateral Sclerosis
      