['ulcerative colitis']
['glpg1205', 'placebo']

        Inclusion Criteria:

          -  Male or female subjects between 18 and 75 years

          -  Documented history of UC

          -  Presence of active UC for a minimum period of 14 days prior to screening and spread
             beyond the rectum, Mayo score ≥ 6 with rectal bleeding score ≥ 1 and endoscopy score ≥
             2

          -  Absence of infectious colitis

          -  Tumor necrosis factor alpha (TNFα) inhibitor-naive subjects should have failed at
             least 1 prior conventional therapy

          -  Continuation of concurrent treatment with oral steroids (≤30 mg prednisolone eq/day),
             immunosuppressants and 5-aminosalicylates at stable dose is allowed

          -  Female subjects must have a negative blood pregnancy test, unless they are surgically
             sterile, had a hysterectomy, or have been postmenopausal for at least 1 year

          -  Subjects will have to use highly effective contraceptive methods

        Exclusion Criteria:

          -  History of sensitivity to any component of the study drug, or a history of drug or
             other allergy

          -  Any concurrent illness, condition, disability, or clinically significant abnormality
             that, in the investigator's opinion, represents a safety risk for the subject's
             participation, may affect the interpretation of data, or may prevent the subject from
             safely completing the assessments

          -  History of significant psychological, neurologic, hepatic, renal, endocrine,
             cardiovascular, GI (other than UC), pulmonary, or metabolic disease

          -  History of active infections requiring intravenous antibiotics within the past 4 weeks
             prior to screening.

          -  History of malignancy within the past 5 years; presence or history of intestinal
             malignancy

          -  History of bowel surgery within 6 months prior to screening; history of colon
             resection with < 30 cm of the colon remaining

          -  Suspicion of Crohn's disease, indeterminate colitis, microscopic colitis, ischemic
             colitis, diverticular disease-associated colitis, or radiation-induced colitis

          -  Subject who has received non-permitted UC therapies within specified timeframes,
             depending on the medication, as stated in the protocol

          -  Subject who is pregnant or lactating
      