['appendicitis']
['a combination of fosfomycin, metronidazole and gm-csf i.p.']

        Inclusion Criteria:

          -  Men ≥18 years old

          -  Suspicion of acute appendicitis and planned for diagnostic laparoscopy and eventual
             appendectomy

          -  Written informed consent after written and verbal information

        Exclusion Criteria:

          -  Cannot understand, read or speak Danish

          -  Previous allergic reaction to fosfomycin, metronidazole, or GM-CSF

          -  Perforated appendicitis (diagnosed either during surgery or at a preoperative computer
             tomography (CT) scan)

          -  Diagnostic laparoscopy revealing normal appendix not requiring an appendectomy

          -  Other intra-abdominal pathology requiring surgical intervention (diagnosed either
             during surgery or at a preoperative CT-scan)

          -  Known renal or hepatic disease or biochemical evidence at the time of admission

          -  Known autoimmune disease or other chronic inflammation

          -  Known hematologic disease or cancer

          -  Previous abdominal surgery (either laparoscopic or open surgery)

          -  Daily use or use of medication one week prior to or during the trial period apart from
             painkillers such as paracetamol, ibuprofen, tramadol, and morphine as well as drugs
             needed for anaesthesia, thrombosis prophylaxis, and nausea. Limitations for
             antibiotics are defined below

          -  Use of other antimicrobial agents than the trial treatment one month before until 24
             hours after the trial treatment

          -  Participant in another drug trial one month prior to the date of the surgery

          -  Body mass index ≥35 kg/m2

          -  Weekly intake of alcohol >14 units, where one unit corresponds to 12 g alcohol
      