['leukemia, myeloid, acute']
['gmi-1271', 'mitoxantrone', 'etoposide', 'cytarabine', 'idarubicin']

        Inclusion criteria:

          1. AML (including secondary AML) diagnosed as per WHO criteria

          2. For relapsed/refractory subjects only:

               -  Subjects age ≥ 18 years with relapsed or refractory AML after ≤ 2 prior induction
                  regimens, at least one containing anthracyclines

               -  Medically eligible to receive MEC

               -  Absolute blast count (ABC) ≤ 40,000/mm

          3. For treatment-naïve subjects only:

               -  Subjects ≥ 60 years of age with newly diagnosed AML

               -  Medically eligible to receive "7+3" cytarabine/idarubicin

               -  ABC count ≤ 40,000/mm

          4. ECOG performance status 0-2

          5. Hemodynamically stable and adequate organ function

        Exclusion criteria:

          1. Acute promyelocytic leukemia

          2. Acute leukemia of ambiguous lineage (biphenotypic leukemia)

          3. Active signs or symptoms of CNS involvement by malignancy

          4. No prior G-CSF, GM-CSF or plerixafor within 14 days of study drug dosing

          5. Known history or evidence of active hepatitis A, B, or C or HIV

          6. Uncontrolled acute life threatening bacterial, viral or fungal infection

          7. Active graft versus host disease (GVHD) ≥ Grade 2 or extensive chronic GVHD requiring
             immunosuppressive therapy

          8. Hematopoietic stem cell transplantation ≤ 4 months of dosing

          9. Clinically significant cardiovascular disease
      