['healthy']
['palbociclib alone', 'palbociclib plus modafinil', 'palbociclib alone', 'palbociclib plus pioglitazone']

        Inclusion Criteria:

          -  Healthy male and/or female subjects of non childbearing potential between the ages of
             18 and 55 years, inclusive.

          -  Body Mass Index (BMI) of 17.5 to 30.5 kg/m2; and a total body weight >50 kg (110 lbs).

          -  Evidence of a personally signed and dated informed consent document indicating that
             the subject has been informed of all pertinent aspects of the study.

          -  Subjects who are willing and able to comply with all scheduled visits, treatment plan,
             laboratory tests, and other study procedures.

        Exclusion Criteria:

          -  Evidence or history of clinically significant hematological, renal, endocrine,
             pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or
             allergic disease.

          -  Any condition possibly affecting drug absorption (eg, gastrectomy).

          -  Subjects with a self-reported history of addiction, especially to stimulants.

          -  A positive urine drug screen or alcohol breath test.

          -  Pregnant female subjects; breastfeeding female subjects; female subjects of
             childbearing potential; male subjects with partners currently pregnant; male subjects
             of childbearing potential who are unwilling or unable to use a highly effective method
             of contraception as outlined in this protocol for the duration of the study and for 90
             days after the last dose of investigational product.
      