['fibromyalgia', 'myofascial pain syndromes', 'muscular diseases', 'musculoskeletal diseases', 'nervous system diseases', 'neuromuscular diseases', 'rheumatic diseases']
['tnx-102 sl tablet, 2.8mg', 'placebo sl tablet']

        Inclusion Criteria:

          -  Diagnosis of Primary Fibromyalgia (2010 ACR criteria)

          -  Male or female 18-75 years old

          -  For patients with major depressive disorders only: clinically stable, no suicidal risk
             and stable anti-depressant therapy

          -  Willing and able to withdraw specific therapies (ask PI)

          -  Medically acceptable form of contraception (female only)

          -  Signed informed consent

        Exclusion Criteria:

          -  Arthritis, lupus and other systemic auto-immune diseases

          -  Regional or persistent pain that could interfere with assessment of fibromyalgia pain

          -  Bipolar and psychotic disorders

          -  Increased risk of suicide

          -  Significant clinical (cardiac, systemic infection, systemic corticosteroid
             requirement, drug/alcohol abuse) or laboratory abnormalities.

          -  Unability to wash-out specific medications (ask PI)

          -  Known hypersensitivity to cyclobenzaprine

          -  Others: seizure disorders, severe/untreated sleep apnea, BMI>40
      