['advanced solid tumors']
['pqr309']

        Inclusion Criteria:

          -  Histologically or cytologically confirmed diagnosis of advanced solid tumor for which
             no therapy of proven efficacy is available.

          -  Age ≥ 18

          -  Evidence of tumor progression with measurable or evaluable disease.

          -  Use of adequate contraceptive measures for male patients.

          -  Eastern Cooperative Oncology Group (ECOG) Performance Score of 0-1.

          -  Signed informed consent.

        Exclusion Criteria:

          -  Concomitant anticancer therapy (e.g., chemotherapy, radiotherapy, hormonal,
             immunotherapy, biological response modifier, signal transduction inhibitors)

          -  Patients with a history of myocardial infarction or coronary artery bypass within the
             last 3 years.

          -  Patients with severe/unstable angina, coronary/peripheral arterial bypass, symptomatic
             congestive heart failure NYHA Class 3 or 4, hypertension BP>150/100mmHg.

          -  Pre-diagnosed diabetes mellitus.

          -  Fasting glucose > 7.0 mmol/L or HbA1c > 6%.
      