
    insufficient accrual
  
['castration-resistant prostate cancer']
['cyclophosphamide']

        Inclusion Criteria:

          -  Histologically or cytologically confirmed adenocarcinoma of the prostate

          -  Radiographically documented metastatic disease with evidence of disease progression
             Laboratory parameters per protocol

          -  Surgically or medically castrate

          -  Patients who have progressed following:

          -  a. at least initial therapy (chemotherapy or treatment with a hormonal agent known to
             impact survival such as abiraterone and enzalutamide); or

          -  b. one first-line chemotherapy regimen and one additional hormonal agent known to
             impact survival such as abiraterone and enzalutamide; or

          -  c. failure of two lines of chemotherapy; or

          -  d. failure of pre-chemotherapy abiraterone or enzalutamide and subsequent chemotherapy

        Exclusion Criteria:

          -  Patients with neuroendocrine or small cell cancer of the prostate 2. History of other
             malignant disease (with the exception of the primary prostate cancer and non-melanoma
             skin tumors) in the past 5 years Pre-defined co-morbidities

          -  Administration of experimental therapy within the last 4 weeks before start of
             screening

          -  Treatment with immunotherapy within the last 3 months before start of screening

          -  Treatment with radiopharmaceutical drugs within 8 weeks before start of screening

          -  Receipt of oncolytic virus treatment or vaccination with a live virus within 4 weeks
             of study start

          -  History of organ transplantation
      