['vascular diseases', 'cardiovascular diseases', 'acute myocardial infarction']
['doxycycline']

        Inclusion Criteria:

          -  age ≥ 18 and ≤ 75 years at time of randomization (18 years and older)

          -  ST-elevation Q wave myocardial infarction

          -  term admission to an intensive care unit (ICU) in the first 24 hours of onset

          -  the reperfusion of the infarct-related coronary artery is not later than 24 hours
             after the initial onset of acute transmural myocardial infarction

          -  written the informed consent to participate in research

        Exclusion Criteria:

          -  atrial fibrillation, a permanent form

          -  valvular heart disease

          -  severe comorbidity

          -  acute heart failure according to the Killip classification IV FC (functional class)

          -  history of chronic heart failure (NYHA III-IV)

          -  poor image quality for Echocardiography

          -  sinus bradycardia - heart rate of under 50 beats per minute, interventricular
             conduction delay (QRS > 0,11 s.) and atrioventricular block II-III degree
      