['chronic obstructive pulmonary disease']
['beclometasone/formoterol/glycopyrrolate', 'beclometasone/formoterol']

        Inclusion Criteria:

          -  Male or female adults aged ≥ 40 years with a diagnosis of COPD

          -  Current smokers or ex-smokers

          -  A post-bronchodilator FEV1 < 50% of the predicted normal value and a post-
             bronchodilator FEV1/FVC < 0.7

          -  At least one exacerbation in the 12 months preceding the screening visit

        Exclusion Criteria:

          -  Pregnant or lactating women

          -  Diagnosis of asthma or history of allergic rhinitis or atopy

          -  Patients treated with non-cardioselective β-blockers in the month preceding the
             screening visit

          -  Patients treated for exacerbations in the 4 weeks prior to screening visit

          -  Patients treated with long-acting antihistamines unless taken at stable regimen at
             least 2 months prior to screening and to be maintained constant during the study or if
             taken as PRN

          -  Patients requiring long term (at least 12 hours daily) oxygen therapy for chronic
             hypoxemia

          -  Known respiratory disorders other than COPD

          -  Patients who have clinically significant cardiovascular condition
      