['chronic obstructive pulmonary disease']
['bdp/ff/gb', 'tiotropium', 'bdp/ff + tiotropium']

        Inclusion Criteria:

          -  Male and female COPD patients aged ≥ 40 years

          -  Current smokers or ex-smokers

          -  FEV1<50% predicted (FEV1/FVC <0,7)

          -  at least 1 documented exacerbations in the last 12 Mo

        Exclusion Criteria:

          -  Pregnant or lactating women and all women physiologically capable of becoming pregnant

          -  Diagnosis of asthma, history of allergic rhinitis or atopy

          -  Patients treated for exacerbations 1 Mo prior to screening

          -  Patients treated with non-cardioselective β-blockers

          -  Patients treated with long-acting antihistamines

          -  Known respiratory disorders other than COPD

          -  Patients who have clinically significant cardiovascular condition
      