
    failure to recruit
  
['hypertension']
['abatacept', 'placebo']

        Inclusion Criteria:

          -  Men and women 18 to 65 years of age with hypertension, treated with three or more
             anti-hypertensive drugs, one being a diuretic, and

          -  having a systolic blood pressure >150 mmHg in the clinic and daytime average >150 mmHg
             on ambulatory blood pressure monitoring

        Exclusion Criteria:

          -  Medical history of secondary cause of hypertension, severe obesity (BMI >35), severe
             psychiatric disorders, cancer in the last 5 years other than nonmelanoma skin cell
             cancers, herpes zoster or cytomegalovirus that resolved less than 2 months before

          -  Inability to return for abatacept treatment and follow-up for 24 weeks.

          -  Inability to understand or complete study-related assessments.

          -  Current abuse of drugs or alcohol.

          -  Receipt of any live vaccines within 3 months of the anticipated first dose of study
             medication.

          -  Evidence of active or latent bacterial or viral infections at the time of potential
             enrollment, including human immunodeficiency virus (HIV)

          -  Risk for tuberculosis

          -  Abnormal laboratory values including positive hepatitis B surface antigen, hemoglobin
             < 8.5 g/dL, white blood cell count < 3000/mm3, platelets < 100,000/mm3, creatinine >
             2.5 times the upper limit of normal (ULN), alanine aminotransferase or aspartate
             aminotransferase > 2 times the ULN.
      