
    no signal of efficacy with entospletinib
  
['hematologic malignancy', 'acute myeloid leukemia']
['entospletinib', 'daunorubicin', 'cytarabine']

        Key Inclusion Criteria:

          -  ENTO monotherapy (Group A): relapsed or refractory hematologic malignancies by World
             Health Organisation (WHO) criteria and who are not eligible to receive standard of
             care

          -  ENTO + cytarabine + daunorubicin (Group B): previously untreated AML by WHO criteria,
             who are deemed fit for cytarabine and daunorubicin (7+3) induction chemotherapy and
             are able to undergo up to 2 cycles of induction chemotherapy, as determined by the
             treating physician

          -  Must have been born in Japan and must not have lived outside of Japan for a period > 1
             year in the 5 years prior to Day 1 of study treatment

          -  Must be able to confirm the Japanese origin of their maternal and paternal ancestry

        Key Exclusion Criteria:

          -  Known active central nervous system or leptomeningeal leukemic involvement

          -  Ongoing liver injury, or known infection with chronic active hepatitis C virus (HCV)
             or chronic active hepatitis B virus (HBV)

        NOTE: Other protocol defined Inclusion/ Exclusion criteria may apply.
      