
    phase ii funding not available
  
['sinusitis', 'nasal polyps']
['verapamil hydrochloride intranasal']

        Inclusion Criteria:

          -  Patients presenting to the Mass Eye and Ear Sinus Center

          -  Age 18-80 yrs old

          -  Diagnosed with Chronic Rhinosinusitis with Nasal Polyps according to the EPOS 2012
             consensus criteria

          -  Post-operative with a Lund-Kennedy Poly score of <4

          -  Baseline SNOT-22 Score ≥ 30

        Exclusion Criteria:

          -  Patients with the following comorbidities:

          -  GI Hypomotility

          -  Heart Failure

          -  Liver Failure

          -  Kidney Disease

          -  Muscular Dystrophy

          -  Pregnant or Nursing Females

          -  Steroid Dependency

          -  Hypertrophic Cardiomyopathy

          -  Any Atrial or Ventricular arrhythmia (ie. Atrial fibrillation, atrial flutter, etc..)

          -  Resting Heart Rate less than 60 beats per minute

          -  Baseline Systolic Blood Pressure less than 110 mmHg

          -  Baseline Diastolic Blood Pressure less than 70 mmHg

          -  Baseline Mean Arterial Pressure Less than 60 mmHg

          -  PR interval less than 0.12 seconds

          -  Patients taking the following medications:

          -  Aspirin

          -  Beta-blockers

          -  Cimetidine(Tagamet)

          -  Clarithromycin(Biaxin)

          -  Cyclosporin

          -  Digoxin

          -  Disopyramide(Norpace)

          -  Diuretics

          -  Erythromycin

          -  Flecainide

          -  HIV Protease Inhibitors(Indinavir, Nelfinavir, Ritonavir)

          -  Quinidine

          -  Lithium

          -  Pioglitazone

          -  Rifampin

          -  St Johns Wort

          -  Patients with cardiac or conduction abnormality picked up by screening EKG

          -  Post-op patients with surgery within 3 months prior to enrollment.
      