['ischemic stroke']
['placebo']

        Inclusion Criteria:

          -  Acute ischemic stroke

          -  Able to receive IV tPA, mechanical thrombectomy or both

          -  National Institutes of Health Stroke Scale (NIHSS) score of ≥ 5

          -  Signed informed consent

          -  Mechanical thrombectomy subjects only: onset time to arterial puncture time < 6 hours

        Exclusion Criteria:

          -  History of stroke or penetrating head injury within 90 days prior to enrollment

          -  History of previous or current diagnosis of intracranial hemorrhage that represents a
             potential for re-hemorrhage if subjected to thrombolytic therapy or mechanical
             thrombectomy

          -  Moyamoya disease, cerebral arterio-venous malformation (AVM), known unsecured aneurysm
             requiring intervention during the acute study period

          -  Presence of other neurological or non-neurological co-morbidities that may lead,
             independently of the current stroke, to further deterioration in the subject's
             neurological status during the trial period

          -  Presence of premorbid neurological deficits and functional limitations assessed by a
             retrospective Modified Rankin Scale (mRS) score of ≥ 2

          -  Mechanical thrombectomy subjects only: baseline non-contrast CT scan revealing a large
             core occlusion as defined by local protocol

          -  Prolonged prothrombin time (PT) or activated partial thromboplastin time (aPTT)

          -  Severe hypertension or hypotension

          -  Glomerular filtration rate (GFR) <35 mL/min

          -  Blood glucose concentration < 50 mg/dL

          -  Prior exposure to any exogenous form of APC
      