['diabetes mellitus']
['exantide with dapagliflozin', 'exentide', 'dapagliflozin']

        Inclusion criteria

          -  Has a diagnosis of T2DM.

          -  Has HbA1c of 8.0% to 12.0%, inclusive, at Visit 1 and Visit 2.

          -  Treated with a stable dose of metformin ≥1500 mg/day for at least 2 months prior to
             Screening.

        Exclusion criteria

          -  FPG ≥280 mg/dL (15.6 mmol/L).

          -  Serum calcitonin concentration ≥40 pg/mL (≥40 ng/L) at Visit 1 (Screening)

          -  Clinically significant abnormal free T4 values or patients needing initiation or
             adjustment of thyroid treatment according to the investigator.

          -  Abnormal thyroid stimulating hormone (TSH) value at Screening will be further
             evaluated by free T4.Patients with clinically significant abnormal free T4 values will
             be excluded.

          -  Known active proliferative retinopathy.

          -  History of, or currently have, acute or chronic pancreatitis, or have triglyceride
             concentrations ≥500 mg/dL (≥5.65 mmol/L) at Visit 1

          -  History or presence of inflammatory bowel disease or other severe GI diseases,
             particularly those which may impact gastric emptying, such as gastroparesis or pyloric
             stenosis.

          -  History of gastric bypass surgery or gastric banding surgery, or either procedure is
             planned during the time period of the study. Current use of gastric balloons is also
             excluded.
      