['functional constipation']
['yh12852 ir 0.05mg', 'yh12852 ir 0.1mg', 'yh12852 ir 0.3mg', 'yh12852 ir 0.5mg', 'yh12852 ir 1mg', 'yh12852 ir 2mg', 'yh12852 ir 3mg', 'yh12852 dr1 0.5mg', 'yh12852 dr1 1mg', 'yh12852 dr1 2mg', 'yh12852 dr1 4mg', 'yh12852 dr2 8mg', 'prucalopride 2mg', 'placebo']

        Inclusion Criteria:

          1. Subjects must be willing and able to provide written informed consent.

          2. BMI within the range 18 to 25 kg/m2.

        Exclusion Criteria:

          1. History of positive serologic evidence for infectious disease including HBsAg,
             anti-HCV, anti-HIV.

          2. Clinically significant lab/ECG abnormalities in the opinion of the investigator.

          3. WOCBP who are unwilling or unable to use an adequate contraceptive method to avoid
             pregnancy for the entire study. WOCBP include any female who has experienced menarche
             and who has not undergone successful surgical sterilization (hysterectomy, bilateral
             tubal ligation, bilateral tubectomy, or bilateral oophorectomy) or is not
             postmenopausal. Post menopause is defined as amenorrhea for ≥ 12 consecutive months
             without another cause.

             Clinically acceptable contraceptive methods for this study: intrauterine devices
             (e.g., loop), physical barrier method (e.g., diaphragm, uterine cap, condom) with
             chemical barrier method (e.g., spermicide), sterile partner, practicing abstinence.

          4. WOCBP who are willing to use hormonal methods or hormone-releasing device(e.g.,
             mirena, implanon) for the entire study.

          5. WOCBP who are pregnant or breastfeeding.

          6. WOCBP with a positive pregnancy test prior to randomization.

          7. Males who have not received a vasectomy must agree to use contraceptive methods
             defined in (a) and refrain from donating sperm throughout the study.

          8. Presence of uncontrolled or severe medical illness.

          9. Presence of a disease that require surgery at any time during the study.
      