['diabetes mellitus, type 2']
['gwp42004', 'placebo']

        Inclusion Criteria:

          -  Participant is willing and able to give informed consent for participation in the
             study (see Section 15.2).

          -  Male or female participants aged 18 years or above.

          -  Clinically diagnosed with Type 2 diabetes.

          -  Participants receiving oral metformin (≥1000 mg per day) as anti-diabetic treatment
             who have received a stable dose for at least three months prior to enrolment (Visit 1)
             and willing to maintain a stable dose for the duration of the trial.

          -  HbA1c level of >7% - ≤9% (53 - 74.9 mmol/mol).

          -  BMI of >25 - <40 (>23 - <40 for Asian populations).

          -  No changes in diet or exercise for three months prior to study entry and participant
             agrees to keep stable for the duration of the study.

          -  Capable of complying with the study requirements and completing the study (in the
             opinion of the investigator).

          -  Participant is able (in the investigators opinion) and willing to comply with all
             study requirements.

          -  Participant is willing for his or her name to be notified to the responsible
             authorities for participation in this study, as applicable in individual countries.

          -  Participant is willing to allow his or her primary care practitioner and consultant,
             if appropriate, to be notified of participation in the study.

        Exclusion Criteria:

          -  Participant is taking or has taken insulin at any point in the last year (does not
             include short term use (<10 days) to treat acute events).

          -  Participant is taking or has taken anti-diabetic treatment (other than metformin) in
             the three months prior to screening.

          -  Any concomitant medications which, in the opinion of the investigator, could affect
             the primary endpoint should remain stable or not be prescribed in the one month prior
             to Visit 1 or during the study period.

          -  Any known of suspected history of:

          -  Alcohol or substance abuse.

          -  Epilepsy or recurrent seizures.

          -  Participants receiving treatment with antidepressants or under observation for
             depression.

          -  BDI-II item 9 score of 1, 2 or 3.

          -  Participant who has significant history of suicidal ideation or self-harm.

          -  Recent (within three months of screening) blood loss (including blood donation).

          -  Haemolytic anaemia.

          -  Genetic abnormality in haemoglobin molecule (e.g. sickle cell anaemia).

          -  Clinically significant cardiac, renal or hepatic impairment in the opinion of the
             investigator.

          -  Has significantly impaired renal function as evidenced by a creatinine clearance lower
             than 40 mL/min at Visit 1.

          -  Has significantly impaired hepatic function at Visit 1 (alanine aminotransferase (ALT)
             levels >5x upper limit of normal (ULN) or total bilirubin (TBL) levels > 2x ULN). If
             the ALT or aspartate aminotransferase (AST) levels are >3x ULN and the TBL levels >2x
             ULN (or International Normalised Ratio (INR) >1.5), then this participant should not
             enter the study.

          -  Any known or suspected hypersensitivity to cannabinoids or any of the excipients of
             the IMPs.

          -  Female participants of child bearing potential and male participants whose partner is
             of child bearing potential, unless willing to ensure that they or their partner use
             effective double barrier contraception.

          -  Female participant who is pregnant, lactating or planning pregnancy during the course
             of the study and for three months thereafter.

          -  Participants who have received an Investigational Medicinal Product (IMP) within the
             12 weeks prior to the screening visit.

          -  Any other significant disease or disorder which, in the opinion of the investigator,
             may either put the participant at risk because of participation in the study, may
             influence the result of the study, or the participant's ability to participate in the
             study.

          -  Following a physical examination, the participant has any abnormalities that, in the
             opinion of the investigator would prevent the participant from safe participation in
             the study.

          -  Unwilling to abstain from donation of blood during the study.

          -  Participants who have previously undergone bariatric surgery.

          -  Travel outside the country of residence planned during the study, unless the
             participant has prior permission from the embassy of the destination country.

          -  Participants previously randomised into this study.

          -  The patient is currently using or has used cannabis or cannabinoid based medications
             within 30 days of study entry and is unwilling to abstain for the duration of the
             study.
      