
    low participant enrolment
  
['stroke']
['basmisanil', 'placebo']

        Inclusion Criteria:

          -  Radiologic assessment confirming an acute middle cerebral artery ischemic stroke

          -  Index stroke occurred within the past 3-4 days

          -  Inpatient males and females

          -  Severe hemiparesis or hemiplegia defined by FMMS score less than or equal to (</=) 35

          -  Sufficient speech, vision and hearing to participate in study evaluations

        Exclusion Criteria:

          -  NIHSS greater than (>) 20

          -  Severe aphasia that prevents a participant from following directions in rehabilitation

          -  Significant deficit from prior strokes or pre-existing motor deficit

          -  History of epilepsy, neurosurgery, severe head trauma or central nervous system
             infections that have residual symptomatology or have required treatment in the last 12
             months

          -  Known or suspected clinical seizure post-index stroke

          -  History of pre-existing dementia or use of medications for dementia

          -  History of clinically significant pre-existing psychiatric conditions within 12 months
             prior to stroke

          -  Due to undergo carotid surgery within the next 4 months

          -  Enrollment/participation in any interventional study (clinical trial) involving an
             investigational drug (unapproved) or non-drug treatment within the prior 3 months or 6
             times the half-life (whichever is longer)

          -  Clinically relevant medical conditions that would likely interfere with the study
             conduct and scheduled assessments

          -  Contraindication to magnetic resonance imaging (MRI) or conditions which render
             interpretation of MRI difficult
      