['multiple myeloma']
['daratumumab', 'velcade (bortezomib)', 'dexamethasone']

        Inclusion Criteria:

          -  Must have had documented multiple myeloma

          -  Must have received at least 1 prior line of therapy for multiple myeloma

          -  Must have had documented evidence of progressive disease as defined based on
             Investigator's determination of response of International Myeloma Working Group (IMWG)
             criteria on or after their last regimen

          -  Must have an Eastern Cooperative Oncology Group Performance Status score of 0, 1, or 2

          -  Must have achieved a response (partial response [PR] or better based on investigator's
             determination of response by the IMWG criteria) to at least 1 prior regimen in the
             past

        Exclusion Criteria:

          -  Has received daratumumab or other anti-CD38 therapies previously

          -  Is refractory to VELCADE or another PI, like ixazomib and carfilzomib (had progression
             of disease while receiving VELCADE therapy or within 60 days of ending VELCADE therapy
             or another PI therapy, like ixazomib and carfilzomib

          -  Is intolerant to VELCADE (ie, discontinued due to any adverse event while on VELCADE
             treatment)

          -  Has received anti-myeloma treatment within 2 weeks or 5 pharmacokinetic half-lives of
             the treatment, whichever is longer, before the date of randomization. The only
             exception is emergency use of a short course of corticosteroids (equivalent of
             dexamethasone 40 milligram per day [mg/day] for a maximum of 4 days) before treatment.
             A list of anti-myeloma treatments with the corresponding pharmacokinetic half-lives is
             provided in the Site Investigational Product Procedures Manual (IPPM).

          -  Has a history of malignancy (other than multiple myeloma) within 3 years before the
             date of randomization

          -  Has any concurrent medical condition or disease (eg, active systemic infection) that
             is likely to interfere with study procedures
      