
    couldn't enough accrue patients
  
['constipation']
['naloxegol']

        Inclusion Criteria:

          -  Adults greater than or equal to 18 years old.

          -  Eastern Cooperative Oncology Group (ECOG) less than or equal to 3.

          -  Glomerular filtration rate (GFR) greater than or equal to 30 ml/min/1.73m2 by
             Modification of Diet in Renal Disease (MDRD).

          -  Corrected serum calcium level less than or equal to 10.5 mg/dL.

          -  Estimated life expectancy greater than or equal to 6 months.

          -  Negative pregnancy test prior to initiating study treatment for females of
             childbearing potential.

        Exclusion Criteria:

          -  Patients receiving the following medications within 3 days of Study Day 1 and/or are
             planned to receive throughout the duration of the study period: opioid antagonist,
             mixed antagonist, a strong CYP3A4 and/or P-glycoprotein (P-gp) inhibitor, a moderate
             CYP3A4 and/or P-gp inhibitor, and/or a strong CYP3A4 inducer.

          -  Concurrent total parenteral nutrition and/or use of metoclopramide.

          -  Patients at high risk for bowel perforation.

          -  Constipation that was not primarily caused by opioids in the investigator's medical
             opinion.

          -  A condition that may have affected the permeability of the blood-brain barrier (e.g.,
             known brain metastases, meningeal metastases, brain injury, multiple sclerosis, recent
             brain injury, uncontrolled epilepsy)

          -  Patient has clinically active diverticular disease.

          -  Past medical history of irritable bowel syndrome, signs of active gastrointestinal
             (GI) bleeding, acute surgical abdomen, bowel stents, indwelling peritoneal catheter,
             mechanical GI obstruction, fecal impaction, or fecal ostomy.

          -  Patient has motility/neurologic disorders including autonomic failure (spinal cord
             lesions, tumor invasion of nerves) and/or poorly controlled endocrine/metabolic
             disorders (hypercalcemia, hypokalemia, diabetes, hypothyroidism), as determined by the
             investigator.

          -  Uncontrolled cancer pain despite analgesic therapy
      