['ischemic stroke']
['simvastatin 10 mg', 'simvastatin 40 mg']

        Inclusion Criteria:

          -  Patient with acute ischemic stroke has symptom onset less than 24 hours.

          -  Patient has 18 to 85 years old.

          -  Patient has been obtained describe the study and sign on informed consent.

        Exclusion Criteria:

          -  Patient has indication for simvastatin or ya-hom-navakote.

          -  Patient has pre-stroke mRS score more than 1.

          -  Patient was enrolled in other study within 30 days ago.

          -  Researchers consider that could be harmed by the participants or have certain
             conditions that could affect the participation in research, such as last stage of
             cancer.

          -  According to medical research suggests that patients unable to cooperate in research
             or inappropriate in joint research with other causes.

          -  Conscious level has >2 scores on question 2 of NIHSS.

          -  Platelet counts have less than 100,000 cells per cubic milliliter.

          -  Hematocrit has less than 0.25

          -  Blood sugar (BS) has less than 60 mg/dl or more than 200 ml/dl or between 200 and 300
             mg/dl and treated with diabetes drug until the BS levels have less than 200 mg/dl can
             include for the project before receive the researched drug.

          -  Patient with uncontrolled hypertension by measure systolic blood pressure (SBP) has
             more than 200 mmHg and/or diastolic blood pressure (DBP) has more than 110 mmHg before
             receive the researched drug or patient that receive aggressive treatment.

          -  Patient with others stroke or severe head injury within 6 weeks before enrolled to the
             project.

          -  Patient is received severe surgery within 14 days before enrolled to the project.

          -  Patient has seizure with acute ischemic stroke.

          -  Patient has acute myocardial infarction (AMI) or coronary heart disease (CHD) within 3
             weeks before enrolled to the project.

          -  Patient who receives lower-lipid level drug i.e. Ezetrol, Fenofibrate, Gemfibrosil,
             and Niacin or statin drugs i.e. Atorvastatin and Pitavastatin.

          -  Patient has increasing liver enzyme level or liver abnormal disease.
      