['major depressive disorder']
['esketamine', 'placebo']

        Inclusion Criteria:

          -  Participants must meet Diagnostic and Statistical Manual of Mental Disorders, fourth
             edition (DSM-IV) diagnostic criteria for major depressive disorder

          -  Participants must have current suicidal ideation with intent

          -  In the Investigator's opinion, participant must be in need of acute psychiatric
             hospitalization due to imminent risk of suicide

          -  Participant has a Montgomery Asberg Depression Rating Scale (MADRS) total score of
             greater than or equal to (>=) 22 predose on Day 1

          -  As part of standard of care treatment, participant agrees to be hospitalized
             voluntarily for a recommended period of 5 days after randomization (that is, through
             Day 5), and take prescribed non-investigational antidepressant therapy(ies) for at
             least the duration of the double-blind treatment phase (Day 25)

        Exclusion Criteria:

          -  Participant has a current clinical diagnosis of bipolar or related disorders,
             intellectual disability, or cluster b personality disorder (example, borderline
             personality disorder, antisocial personality disorder, histrionic personality
             disorder, and narcissistic personality disorder)

          -  Participant meets DSM-IV criteria for borderline personality disorder, based on
             clinical interview

          -  Participant has a current or prior diagnosis of a psychotic disorder, major depressive
             disorder (MDD) with psychosis, or obsessive compulsive disorder

          -  Participant with a history or current signs and symptoms of liver or renal
             insufficiency; significant cardiac, vascular, pulmonary, gastrointestinal, endocrine,
             neurologic, hematologic, rheumatologic, or metabolic disturbances

          -  Participant has uncontrolled hypertension (systolic blood pressure greater than [>]
             160 millimeter of mercury [mmHg] or diastolic blood pressure > 90 mmHg) despite diet,
             exercise or a stable dose of an allowed anti-hypertensive treatment at Screening; or
             any past history of hypertensive crisis
      