
    study site change
  
['advanced cancer']
['chlorogenic acid']

        Inclusion Criteria:

          -  advanced cancer with no effective treatment

          -  Karnofsky performance status no less than 70

          -  adequated organ function

          -  informed consent

        Exclusion Criteria:

          -  allergic to chlorogenic acid

          -  persistent toxicities from previous treatment (no less than grade 2)
      