
    lack of recruitment
  
['nicotine dependence']
['mifepristone', 'placebo']

        Inclusion Criteria:

          -  Male smokers aged 18 to 55 years;

          -  History of smoking at least 5 cigarettes daily for the past 12 months;

          -  In good health as verified by medical history, screening examination, and -screening
             laboratory tests

        Exclusion Criteria:

          -  History of mifepristone allergy;

          -  Requirement of any form of regular psychotropic medication (antidepressants,
             antipsychotics, or anxiolytics) and recent psychiatric history (in the past 6 months);

          -  Medical illnesses including diabetes, cardiovascular, renal, endocrine, or hepatic
             disorders;

          -  Prolonged QTc interval >450 msec;

          -  History of adrenal insufficiency or a morning plasma cortisol level less than 5 mcg/dl
             at screening;

          -  Hypokalemia at screening (defined as potassium level < 3.5 mEq/L);

          -  Current use of clinically significant CYP 3A4 substrates including, simvastatin,
             lovastatin, cyclosporine, ergotamines, fentanyl, pimozide, quinidine, sirolimus,
             tacrolimus, triazolam, midazolam.

          -  use of rifapentin, phenobarbital, phenytoin, carbamazepine, and St. John's Wort.

          -  Current use of strong 3A4 inhibitors including ketoconazole, itraconazole, nefazodone,
             ritonavir, nelfinavir, indinavir, atazanavir, amprenavir, fosamprenivir, boceprevir,
             clarithromycin, conivaptan, lopinavir, mibefradil, posaconazole, saquinavir,
             telaprevir, telithromycin, voriconazole.

          -  Treatment with systemic corticosteroids

          -  Current use of clinically significant CYP 3A inducers (e.g., rifampin, rifabutin);

          -  Abuse of alcohol or any other illicit or prescription drugs;

          -  Inability to tolerate cold exposure due to conditions such as peripheral -vascular
             disease or Raynaud's phenomenon;

          -  Inability to fulfill all scheduled visits and examination procedures throughout the
             study period.
      