['multiple sclerosis']
['oxcarbazepine', 'placebo']

        Inclusion Criteria:

          -  A diagnosis of definite multiple sclerosis

          -  Treatment with DMDs for at least 6 months prior to baseline visit*

          -  CSF NFL level ≥ 0.380ng/mL

          -  EDSS score between 3.5 and 6.0

          -  No history of relapses in the 6 months prior to the baseline visit

          -  A history of slow progression of disability, objective or subjective, over a period of
             at least 6 months prior to baseline

          -  Age 18-60 years

               -  [Temporary interruption is permitted at the discretion of the investigator for a
                  period of up to 8 weeks to prevent inflammatory MS reactivation. The cases where
                  this could happen include for example switching DMDs that require a washout
                  period as per clinical practice. When there are safety concerns, as in
                  Lymphopenia or other side effects induced by the DMD, the interruption period can
                  exceed 8 weeks as per clinical need. If reactivation of MS occurs with a relapse
                  the investigator will assess if this meets withdrawal criteria 6.]

        Exclusion Criteria:

          -  Pregnant or breastfeeding or unwilling to use adequate contraception.*

          -  Participants with a diagnosis of primary progressive PP MS or primary relapsing PR MS.

          -  A clinical relapse or pulsed intravenous or oral steroids in the 6 months preceding
             the baseline assessment.

          -  Participants presenting with medical disorder deemed severe or unstable by the CI such
             as poorly controlled diabetes or arterial hypertension, severe cardiac insufficiency,
             unstable ischemic heart disease, abnormal liver function tests (>2.5 times ULN) and
             abnormal complete blood count (in particular leukopenia, as defined by a lymphocyte
             count <500, neutrophil count <1.5 or platelet count <100, or thrombocytopenia <1.5
             LLN), or any medical condition which, in the opinion of the investigator, would pose
             additional risk to the participant.

          -  Infection with hepatitis B or hepatitis C or human immunodeficiency virus.

          -  Exposure to any other investigational drug within 30 days of enrolment in the study.

          -  Judged clinically to have a suicidal risk in the opinion of the investigator based
             upon a clinical interview and the Columbia Suicide-Severity Rating Scale (CSSRS).

          -  Prior history of malignancy unless an exception is granted by the Investigator.

          -  History of uncontrolled drug or alcohol abuse within 6 months prior to screening.

          -  Past untoward reactions to OxCbz or Cbz

          -  Participants receiving OxCbz or Cbz in the previous 12 weeks from baseline

               -  [Adequate methods of contraception are non hormonal methods such as barrier
                  methods, intrauterine devices, surgical sterilisation (undergone by the
                  participant or their partner). Female participants using hormonal only forms of
                  contraception will be required to use an additional barrier method. True
                  abstinence can be considered an acceptable method of contraception when this is
                  in line with the preferred and usual lifestyle of the subject. Periodic
                  abstinence (e.g., calendar, ovulation, symptothermal, post-ovulation methods),
                  declaration of abstinence for the duration of a trial, and withdrawal are not
                  acceptable methods of contraception. Non sexually active participants or those in
                  same sex relationships will not be required to commence contraception.]
      