['elevated lipoprotein(a)', 'cardiovascular disease']
['isis 681257', 'placebo']

        Key Inclusion Criteria:

          -  Clinical diagnosis of CVD defined as documented coronary artery disease, stroke, or
             peripheral artery disease

          -  Lp(a) plasma level ≥ 60 mg/dL

          -  Must be on standard-of-care preventative therapy for other than elevated Lp(a) CVD
             risk factors

        Key Exclusion Criteria:

          -  Within 6 months of Screening: acute coronary syndrome, major cardiac surgery, or
             stroke/TIA

          -  Within 3 months of Screening: coronary, carotid, or peripheral arterial
             revascularization, major non-cardiac surgery, or lipoprotein apheresis

          -  Heart failure New York Heart Association (NYHA) class IV
      