['alcohol dependence']
['nalmefene hydrochloride', 'placebo']

        Inclusion Criteria:

          -  Japanese males and females aged 20 or above who have signed the informed consent form

          -  The patient has alcohol dependence, diagnosed according to Diagnostic and Statistical
             Manual of Mental Disorders, 4th Edition, Text Revision (DSM-IV-TR) and confirmed by
             Mini-international Neuropsychiatric Interview (M. I. N. I.)

          -  The patient has a drinking risk level of High or above (> 60 g for men and > 40 g for
             women) both at the Screening Visit and at the Randomization Visit .

        Exclusion Criteria:

          -  The patient with a current diagnosis or history of substance use disorders (except for
             alcohol, nicotine, and caffeine), according to DSM-IV-TR and confirmed by M. I. N. I.

          -  The patient has reported current use of, or has tested positive for, drugs of abuse
             (opiates, methadone, cocaine, amphetamines, barbiturates) at the screening test
      