['breast cancer']
['fec chemotherapy', 'docetaxel', 'pertuzumab', 'placebo', 'trastuzumab']

        Inclusion Criteria:

          -  Histologically confirmed invasive breast carcinoma with a primary tumor size of more
             than (>) 2 centimeters (cm) by standard local assessment technique

          -  Breast cancer stage at presentation: early-stage (T2-3, N0-1, M0) or locally advanced
             (T2-3, N2 or N3, M0; T4, any N, M0)

          -  HER2-positive breast cancer confirmed by a Sponsor-designated central laboratory and
             defined as 3+ score by immunohistochemistry in > 10 percent (%) of immunoreactive
             cells or HER2 gene amplification (ratio of HER2 gene signals to centromere 17 signals
             equal to or more than [>=] 2.0) by in situ hybridization

          -  Known hormone receptor status (estrogen receptor and/or progesterone receptor)

          -  Eastern Cooperative Oncology Group Performance Status equal to or less than (<=) 1

          -  Baseline left ventricular ejection fracture >= 55% measured by echocardiography
             (preferred) or multiple gated acquisition scan

          -  Negative serum pregnancy test

        Exclusion Criteria:

          -  Stage IV metastatic breast cancer

          -  Inflammatory breast cancer

          -  Previous anti-cancer therapy or radiotherapy for any malignancy

          -  History of other malignancy within 5 years prior to screening, except for
             appropriately-treated carcinoma in situ of the cervix, non-melanoma skin carcinoma, or
             Stage I uterine cancer

          -  Concurrent anti-cancer treatment in another investigational trial, including hormone
             therapy, bisphosphonate therapy, or immunotherapy

          -  Major surgical procedure unrelated to breast cancer within 4 weeks prior to
             randomization or from which the participant has not fully recovered

          -  Serious cardiac illness or medical condition

          -  Other concurrent serious diseases that may interfere with planned treatment, including
             severe pulmonary conditions/illness

          -  Any abnormalities in liver, kidney or hematologic function laboratory tests
             immediately prior to randomization

          -  Sensitivity to any of the study medications, any of the ingredients or excipients of
             these medications, or benzyl alcohol

          -  Pregnant or lactating
      