
    study closed with no enrollment due to unavailability of reagent.
  
['leukemia']
['fludarabine', 'cyclophosphamide', 'rituximab', 'bendamustine']

        Inclusion Criteria:

          1. Patients with B cell CLL/SLL, age </= 85 years old, who have active disease that meets
             2008 IWCLL/NCI-WG criteria to initiate treatment.

          2. Patients who have failed at least one line of a standard treatment, including
             bendamustine, fludarabine, ibrutinib, or alemtuzumab and require treatment within 2
             years of completion of last treatment regimen or untreated patients with del17p by
             FISH (high-risk) who do not have an allogeneic stem cell transplant option.

          3. At least 21 days from last cytotoxic chemotherapy.

          4. Eastern Cooperative Oncology Group Performance Status (ECOG PS) <2.

          5. Adequate hepatic function, defined as substance glutamate pyruvate transaminase (SGPT)
             <3 x upper limit of normal (ULN); serum bilirubin and alkaline phosphatase <2 x ULN,
             or considered not clinically significant by the study doctor or designee.

          6. Adequate renal function, defined as serum creatinine <2 x ULN.

          7. Able to provide written informed consent, and agree to practicing 2 forms of birth
             control during the study.

          8. Patients must have adequate cardiac function as indicated by New York Heart
             Association (NYHA) classification I or II AND left ventricular ejection fraction of
             >40% and adequate pulmonary function as indicated by room air oxygen saturation of
             >94%.

        Exclusion Criteria:

          1. Surface ROR1 expression by <5% of CLL cells.

          2. Positive beta-HCG in female of child-bearing potential defined as not post-menopausal
             for 12 months or no previous surgical sterilization or lactating females.

          3. Patients with known systemic allergy to bovine or murine products.

          4. Known positive serology for human immunodeficiency virus (HIV) or human anti-mouse
             antibody (HAMA).

          5. Active, uncontrolled autoimmune phenomenon autoimmune hemolytic anemia, idiopathic
             thrombocytopenic purpura (AIHA, ITP) requiring steroid therapy.

          6. Presence of >/= Grade 3 non-hematologic toxicity common terminology criteria (CTC)
             version 4 from the previous treatment.

          7. Concurrent use of investigational therapeutic agent.

          8. Prior allogeneic hematopoietic stem-cell transplantation if evidence of donor
             chimerism persists. Patients with exclusively autologous hematopoiesis are eligible.

          9. Refusal to participate in the long-term follow-up protocol (2006-0676).
      