["crohn's disease"]
['curcumin']

        Inclusion Criteria:

          -  Crohn's disease confirmed by radiographic, endoscopic or histologic criteria

          -  Age > 18 yr

          -  Affiliated to french health insurance

          -  Operated on less than 15 days ago for ileal, colonic or ileo-colonic Crohn's disease
             with all macroscopic lesions being removed, with an anastomosis which can be reached
             by ileocolonoscopy

        Exclusion Criteria:

          -  Ulcerative colitis

          -  Pregnant or nursing woman

          -  Refusal of contraceptive measure for childbearing potential, woman or fertile man

          -  Indication of anti-TNFα treatment

          -  Concomitant treatment including antibiotics, probiotics, mesalazine, methotrexate,
             cyclosporine, tacrolimus, anti-TNFα, ustekinumab, vedolizumab

          -  Concomitant treatment with corticosteroids, except in case of tapering a treatment
             initiated before surgery

          -  Renal insufficiency ( serum creatinine 2N)

          -  Chronic hepatic disease except for primary sclerosing cholangitis

          -  ALAT , ASAT, alkaline phosphatases, or bilirubin > 3N

          -  Current infection to HIV, HBV (except if HBV Ac positives), HCV

          -  Contraindication to thiopurines

          -  Unwillingness of the patient
      