['dry eye syndrome']
['cis-uca ophthalmic solution 1.0%', 'cis-uca ophthalmic solution 2.5%', 'placebo ophthalmic solution']

        Key Inclusion Criteria:

          -  Be at least 18 years of age;

          -  Provide written informed consent;

          -  Have a subject reported history of dry eye;

          -  Have a history of use or desire to use eye drops.

        Key Exclusion Criteria:

          -  Have any clinically significant eye findings that require therapeutic treatment,
             and/or in the opinion of the Investigator may interfere with study parameters;

          -  Have worn contact lenses within 7 days of Visit 1 or anticipate using contact lenses
             during the study;

          -  Have previously had laser-assisted in situ keratomileusis (LASIK) surgery within the
             last 12 months;

          -  Have used Restasis® within 30 days of Visit 1;

          -  Have any planned ocular and/or lid surgeries over the study period;

          -  Be a woman who is pregnant, nursing or planning a pregnancy;

          -  Be unwilling to submit a urine pregnancy test at Visit 1 and Visit 4 (or early
             termination visit) if of childbearing potential;

          -  Have a known allergy and/or sensitivity to the study drug or its components;

          -  Have a condition or be in a situation which the Investigator feels may put the subject
             at significant risk, may confound the study results, or may interfere significantly
             with the subject's participation in the study;

          -  Be currently enrolled in an investigational drug or device study or have used an
             investigational drug or device within 30 days of Visit 1;

          -  Be unable or unwilling to follow instructions, including participation in all study
             assessments and visits.
      