['metastatic non-small cell lung cancer']
['ramucirumab', 'placebo', 'erlotinib', 'gefitinib', 'osimertinib']

        Inclusion Criteria:

          -  Cytologically or histologically confirmed diagnosis of Stage IV NSCLC as defined by
             the American Joint Committee on Cancer Staging Criteria for Lung Cancer (AJCC 7th
             edition 2009).

          -  Eligible for first-line treatment with erlotinib based on documented evidence of tumor
             harboring an activating EGFR mutation [exon 19 deletion or exon 21 (L858R)
             substitution mutation].

          -  Mandatory provision of adequate archived stage IV NSCLC tissue samples or tissue
             samples other than stage IV NSCLC may be acceptable (optional for part C).

          -  At least one measurable lesion.

          -  Life expectancy of at least 3 months.

        Exclusion Criteria:

          -  Known T790M EGFR mutation (not applicable for Part C Period 2).

          -  Known leptomeningeal carcinomatosis, uncontrolled/unstable spinal cord compression, or
             brain metastases.

          -  Serious illness or medical condition.

          -  Ongoing treatment with CYP3A4 inducers or strong inhibitors.

          -  Ongoing therapy with nonsteroidal anti-inflammatory drugs for more than 2 months.

          -  History of gross hemoptysis.

          -  Significant bleeding disorders.

          -  Radiologically documented evidence of major blood vessel invasion or encasement by
             cancer.

          -  Radiographic evidence of intratumor cavitation.

          -  History of gastrointestinal perforation within last 6 months.

          -  History of bowel obstruction, inflammatory enteropathy or extensive intestinal
             resection.

          -  History of any arterial thrombotic event within 6 months prior to enrollment.

          -  The participant has any known significant ophthalmologic abnormalities of the surface
             of the eye.
      