['acidosis']
['placebo', 'trc101']

        Inclusion Criteria:

          -  Estimated glomerular filtration rate (eGFR) of 20 to <60 mL/min/1.73m2

          -  Serum bicarbonate level of 12 to 20 mEq/L

        Exclusion Criteria:

          -  Any level of low serum bicarbonate that, in the opinion of the Investigator, requires
             emergency intervention.

          -  Severe comorbid conditions other than chronic kidney disease.

          -  Chronic obstructive pulmonary disease.

          -  Anticipated changes in doses of any of the following drugs or drug classes: diuretics,
             non-ophthalmic carbonic anhydrase inhibitors, oral diabetes drugs, antihypertensive
             drugs, antacids, H2-blockers, or proton pump inhibitors.

          -  Excluded drugs or drug classes: insulin, non-daily or "as needed" diuretics, herbal
             products, dietary supplements, multivitamins, naturopathic remedies, sodium
             bicarbonate, potassium citrate, sodium citrate or other alkali therapy, non-steroidal
             anti-inflammatory drugs (NSAIDs), fiber supplements, laxatives, calcium and magnesium
             supplements, or electrolyte binders and other binder drugs.
      