
    great difficulties were encountered during recruitment, for fear denozumab. only 2 patients
    have been included since the study start.
  
['anorexia nervosa']
['denosumab subcutaneous injections', 'placebo subcutaneous injections']

        Inclusion criteria:

          -  Patients with a current AN defined by DSM-V criteria

          -  Being female

          -  Age over or equal to 18 years and less or equal to 40 years

             . For patients under 20 years of age, effective bone maturation (attested by a
             radiography of the hip)

          -  Agree to take contraception up to five months after the last injection of denosumab .

          -  Absence of pregnancy evidenced by an interview and a negative assay of human chorionic
             gonadotropin (ßhCG).

          -  Evidence of low BMD determined by Z-score value < -2 DS (at least one site (lumbar
             spine or total proximal femur)

          -  Signing an informed consent.

        Exclusion criteria:

          -  Not affiliated to a social security scheme or not being the beneficiary of such a
             scheme.

          -  Severe hepatic cytolysis with transaminase up to 5 times normal.

          -  Severe dental problems: in case of doubt an assessment by a dentist will be required
             before inclusion.

          -  Desire of pregnancy during the two years of follow-up study.

          -  Disease or treatment potentially responsible for secondary osteoporosis.

          -  Participant already treated with a molecule known to have an effect on bone

          -  Diabetes.

          -  Current hypocalcemia.

          -  Immunodeficiency.

          -  Cancer with bone lesions

          -  Patient on protectice measures (guardianship or trusteeship)

          -  Hypersensitivity to the active substance or to any of the excipients of Prolia®

          -  Unable to read and / or write and understand the methodology of the study

          -  Reporting relationship to the investigator

          -  Anticipate a long stay outside the region that would prevent compliance with the
             schedule of visits

          -  Participation to other biomedical research on health products

          -  Deprived of liberty

          -  Breastfeeding
      