['melanoma']
['vesanoid', 'ipilimumab']

        Inclusion Criteria:

          -  Patients over the age of 18 year.

          -  Patients diagnosed with advanced melanoma.

          -  Patients that are considered candidates for ipilimumab therapy.

          -  Patients able to understand and willing to sign a written informed consent documents.

          -  Patients willing to have regular blood draws, one before treatment and four during or
             after treatment.

        Exclusion Criteria:

          -  Patients under the age of 18.

          -  Patients with Stage I or II, melanoma who are not candidates for Ipilimumab.

          -  Patients that have received systemic treatments within four weeks prior to the
             beginning of treatment.

          -  Women that are pregnant or nursing.

          -  Patients taking immunosuppressive medications.

          -  Patients with active autoimmune disease.

          -  Patients with known sensitivity to retinoic acid derivatives.

          -  Patients with aspartate aminotransferase (AST), alanine aminotransferase (ALT), or
             bilirubin > 2.5 × ULN.
      