
    the study was terminated early due to difficulty in enrollment and lack of clinical study drug
    access.
  
["crohn's disease"]
['rifaximin eir', 'placebo']

        Major Inclusion Criteria:

          -  Moderate, non-fistulizing Crohn's disease in the ileum and/or colon prior to
             randomization; and a SES-CD score of ≥7 (confirmed by centralized endoscopy reading).

          -  During the screening period, the participant will need to have certain average daily
             scores for abdominal pain and average number of liquid/very soft stools.

        Major Exclusion Criteria:

          -  Pregnant or lactating females. Females of childbearing (reproductive) potential must
             have a negative serum pregnancy test at screening and agree to use a highly effective
             method(s) of contraception throughout their participation in the study. Diagnosis of
             ulcerative or indeterminate colitis.

          -  Diagnosis of Celiac Disease.

          -  Bowel surgery within 12 weeks prior to screening and/or has surgery planned or deemed
             likely for Crohn's disease during the study period.

          -  Presence of an ileostomy or colostomy.

          -  Known fixed symptomatic stenosis/stricture of the small or large bowel.

          -  Had more than one segmental colonic resection.

          -  Had more than 3 small bowel resections or symptoms associated with short bowel
             syndrome.

          -  Current evidence of peritonitis.

          -  History or evidence of colonic mucosal dysplasia.

          -  History or evidence of adenomatous colonic polyps that have not been removed.

          -  Unwilling to be tapered off corticosteroids by Week 8 or the participant is known by
             the Investigator to be steroid-dependent.

          -  Has used a biologic within 12 weeks of randomization.

          -  Used cyclosporine, tacrolimus, sirolimus, mycophenolate mofetil, or similar drugs
             within 8 weeks prior to randomization.

          -  Had rectal administration of 5-aminosalicylic acid (5-ASA) or corticosteroid
             enemas/foams/ suppositories within 2 weeks prior to screening visit.
      