
    difficulty to recruit
  
['hiv']
['clopidogrel 300mg tablet', 'prasugrel 60mg']

        Inclusion Criteria:

          -  Healthy males >18 years

          -  Understanding of French language and able to give an inform consent

          -  Anti-HIV therapy with ritonavir or cobicistat (for HIV group)

          -  Stable antiretroviral treatment since at least 2 weeks (for HIV group)

          -  Viremia <100 copies/ml (for HIV group)

        Exclusion Criteria:

          -  renal failure: calculated creatinine Clearance (cockcroft) < 50ml/min

          -  hepatic impairment (ASAT, ALAT, bilirubin, gamma-GT more than 2-fold increase)

          -  smoker >1 pack/day

          -  hypersensitivity to any of the drugs used

          -  intake of any drug or particular food (grapefruit) that can affect CYP activities
             inhibitors (in the last 10 days before the start of the study or 4 half-life after the
             last intake)

          -  pathologies or drugs associated with an increased bleeding risk such as aspirin,
             non-steroidal anti-inflammatory drugs, steroids and serotonin reuptake inhibitors (in
             the last 10 days before the start of the study or 4 half-life after the last intake)

          -  bleeding familial history or antecedent or haemorrhagic disease
      