['rett syndrome']
['nnz-2566', 'placebo']

        Inclusion Criteria:

          -  Diagnosis of classic/typical Rett syndrome with a documented mutation of the MeCP2
             gene.

          -  Age 5 - 15 years.

          -  Weight at Screening and Baseline between 15.0 kg-100.0 kg (at least 15.0 kg and no
             greater than 100.0 kg).

          -  Each subject must be able to swallow the study medication provided as a liquid
             solution, or via gastrostomy tube.

        Exclusion Criteria:

          -  Actively undergoing neurological regression

          -  Abnormal QT interval, prolongation or significant cardiovascular history.

          -  Current treatment with insulin.

          -  Anti-convulsants with liver enzyme inducing effects.

          -  Unstable seizure profile.

          -  Excluded concomitant medications.

          -  Current clinically significant (as determined by the investigator). cardiovascular,
             renal, hepatic, or respiratory disease.

          -  Gastrointestinal disease which may interfere with the absorption, distribution,
             metabolism or excretion of the study medication.

          -  History of, or current cerebrovascular disease or brain trauma.

          -  History of, or current clinically significant endocrine disorder, e.g. hypo- or
             hyperthyroidism, or diabetes mellitus.

          -  History of, or current, malignancy.

          -  Significant hearing and/or visual impairments that may affect ability to complete the
             test procedures.

          -  Allergy to strawberry.
      