['dry eye disease']
['p-321 ophthalmic solution', 'p-321 ophthalmic solution placebo']

        Inclusion Criteria:

          1. Provide written informed consent

          2. Male or female subjects aged 18 to 80 years

          3. Have a history of predominantly tear-deficient dry eye of mild to moderate severity,
             supported by a previous clinical diagnosis

          4. Have normal lid anatomy

          5. Subjects must:

               1. Remain on current medications for the duration of the study and have been on the
                  current medication regimen at least during the past 28 days

        Exclusion Criteria:

          1. Have undergone refractive eye surgery in either eye during the past 12 months

          2. Have undergone uncomplicated cataract surgery in either eye during the past 3 months

          3. Have undergone previous eyelid surgery in either eye (External blepharoplasty, not
             resulting in exposure or abnormal blinking is allowed)

          4. Have undergone botulinum toxin (BotoxTh1 or equivalent) injection in the periocular
             area within 3 months prior to Visit 1

          5. Subjects that have a systemic, multi-organ disease requiring active medical or
             surgical treatment are excluded with the exception of subjects with SS or GVHD

          6. Have punctal plugs, punctal occlusion, history of nasolacrimal duct obstruction or
             wear scleral lens.

          7. Past or present exposure keratopathy, neurotrophic keratopathy, lagophthalmos, or
             trichiasis
      