
    all amgen sponsored amg102 clinical studies were terminated following a pre-planned data
    monitoring committee safety review of study 20070622.
  
['gastric cancer']
['rilotumumab', 'placebo', 'cisplatin', 'capecitabine']

        Key Inclusion Criteria:

          -  Pathologically confirmed unresectable locally advanced or metastatic gastric or GEJ
             adenocarcinoma.

          -  Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1.

          -  Tumor MET-positive by immunohistochemistry (IHC).

          -  Measurable disease by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1
             criteria.

          -  Male or female subject greater than or equal to 20 years of age at the time of
             informed consent.

        Key Exclusion Criteria:

          -  Human epidermal growth factor receptor 2 (HER2)-overexpressing locally advanced or
             metastatic gastric or GEJ adenocarcinoma.

          -  Previous systemic therapy for locally advanced or metastatic gastric or GEJ or lower
             esophageal adenocarcinoma.

          -  Less than 6 months have elapsed from completion of prior neoadjuvant or adjuvant
             chemotherapy or chemoradiotherapy to randomization.

          -  Squamous cell histology.
      