['clostridium difficile infection']
['standard of care antibiotics']

        Inclusion Criteria:

          -  ≥ 18 years old.

          -  Medical record documentation of recurrent CDI including a positive C. difficile test
             within 60 days prior to enrollment and either: a) at least two recurrences after a
             primary episode and has completed at least two rounds of standard-of-care oral
             antibiotic therapy or b) has had at least two episodes of severe CDI resulting in
             hospitalization.

          -  Documented history that the subject's recurrent CDI is controlled while on antibiotics
             even if the subject is not currently on antibiotics.

          -  A positive stool test for the presence of C. difficile within 60 days prior to
             enrollment

        Exclusion Criteria:

          -  A known history of continued CDI diarrhea despite being on a course of antibiotics
             prescribed for CDI treatment.

          -  Requires continuous antibiotic therapy for a condition other than CDI.

          -  Previous successful (resolution of CDI diarrhea) fecal transplant for recurrent CDI <
             6 months prior to study enrollment.

          -  Previous unsuccessful (recurrent CDI diarrhea was unresolved) fecal transplant.

          -  Previous treatment with RBX2660.

          -  Diagnosis of inflammatory bowel disease (IBD), e.g., ulcerative colitis, Crohn's
             disease, or microscopic colitis.

          -  Diagnosis of irritable bowel syndrome (IBS) as determined by Rome III criteria.

          -  History of chronic diarrhea.

          -  History of celiac disease.

          -  Disease symptoms caused by a confirmed intestinal pathogen other than C. difficile.

          -  Colostomy.

          -  Planned surgery requiring perioperative antibiotics within 3 months of study
             enrollment.

          -  Life expectancy of < 12 months.

          -  Compromised immune system
      