['advanced cancer']
['chlorogenic acid']

        Inclusion Criteria:

          1. Patients with pathologic or/and FNAC confirmation of advanced cancer but without
             effective treatment or with treatment failure;

          2. Between 18 and 65 years of age, KPS≥70;

          3. According to RECIST 1.1,patients with at least one tumor lesion that can accurately be
             measured by CT or MRI in at least one dimension with longest diameter to be recorded
             as >2.0cm by general CT or >1.0cm by spiral CT;

          4. Life expectancy of at least three (3) months at the enrollment;

          5. Patients who have sufficient baseline organ function and whose laboratory data can
             meet the following criteria at the enrollment:

               -  PLT count≥100×10~9/L,

               -  WLB count≥4.0×10~9/L and ≤12×10~9/L,

               -  Neutrophil granulocyte count≥2.0×10~9/L,

               -  HGB count≥90g/L,

               -  Total bilirubin <=1.5 times of ULN,

               -  ALT/AST ≤2.5 times of ULN,

               -  SCr≤1.5 times of ULN,

               -  Normal ECG with LVEF (≥50%) measured by echocardiography;

          6. Female patients with negative pregnant test, and male/female patients of reproductive
             age without pregnancy planning in the next 12 months;

          7. Volunteered for the phase 1 trial and sign the informed consent without protest;

        Exclusion Criteria:

          1. Patients who have received large area radiotherapy （>30% marrow capacity）;

          2. Patients who suffer from other serious complication, such as uncontrollable infection,
             myocardial infarction within the past 6 months at the enrollment , uncontrollable
             hypertension ,thromboembolism and etc.;

          3. Symptomatic patients with brain metastases (except for the patients whose brain
             metastases is controlled to stable status after whole brain radiotherapy);

          4. Patients who have received the therapy of chemotherapy within 4 weeks before
             enrollment;

          5. Patients who have used nitrosoureas drug or mitomycin within 6 weeks or tyrosine
             kinase inhibitor within 2 weeks before enrollment;

          6. Patients who have received therapy of major surgery within 6 weeks or biopsy surgery
             within 2 weeks before enrollment;

          7. Patients who or have received radical radiotherapy within 6 weeks or local palliative
             radiotherapy within 2 weeks before enrollment;

          8. Patients who experience grade 2 or more than grade 2 toxicity caused by the past
             therapies;

          9. Patients who have history of drug abuse or alcoholism;

         10. Patients who smoke over 5 cigarettes or equivalent tobacco per day;

         11. Uncontrollable psychopaths;

         12. Pregnant or breast-feeding women, or patients(male and female) who have pregnancy
             plan;

         13. Patients who had received a therapy of another investigational drug within 4 weeks or
             patients who are still in another clinical trial at the enrollment;

         14. Known active hepatitis B/hepatitis C, positive HIV/ syphilis antibody;

         15. Patient who need long term treatment of cortical hormone or other immunosuppressive
             drugs such as visceral organ transplanters;

         16. Allergic to the investigational drug;

         17. Other patients judged ineligible for enrollment in the study by the investigator
             (sub-investigator).
      