['colorectal neoplasms', 'peritoneal neoplasms']
['standard adjuvant systemic chemotherapy']

        Inclusion Criteria:

          -  age between 18 and 75 years

          -  Intention to start routine adjuvant systemic therapy

          -  adequate clinical condition to undergo simultaneous HIPEC or re- laparoscopy or
             re-laparotomy with HIPEC within either 10 days or between week 5-8 from --primary
             resection

          -  written informed consent

          -  white blood cell count of at least 3000/mm3, platelet count of at least 100.000/mm3

          -  no bleeding diathesis or coagulopathy

          -  normal creatinine or creatinine clearance of at least 50 ml/min

        Exclusion Criteria:

          -  postoperative complications that interfere with adjuvant HIPEC within 8 weeks (i.e.
             persisting intra-abdominal abscess, significant fascial dehiscence, enteric fistula)

          -  no intention to start routine adjuvant systemic therapy

          -  liver and/or lung metastases

          -  pregnant or lactating women

          -  unstable or uncompensated respiratory or cardiac disease

          -  serious active infections

          -  other concurrent chemotherapy

          -  hypersensitivity to fluorouracil, folinic acid or another substance of leucovorin or
             oxaliplatin

          -  stomatitis, ulceration in the mouth or gastrointestinal tract.

          -  severe diarrhea

          -  severe hepatic and / or renal dysfunction.

          -  plasma bilirubin concentrations greater than 85 μmol/l.

          -  pernicious anemia or other anaemias due to vitamin B12 deficiency.

          -  peripheral sensory neuropathy with functional impairment.
      