HR-VILAGE-3K3M / Meta_variable_description.csv
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Variable Name,Description
geo_accession,GEO sample accession number (GSM).
ID,Subject identifier within one study (unique per participant); useful when aligning with antibody raw data.
study_ID,Study or cohort identifier
tissue,"Sample source (e.g., whole blood, PBMC, nasal swab)."
platform,"Gene expression platform used (e.g., RNA-seq, microarray, scRNA-seq)."
pathogen,"Infectious agent studied (e.g., SARS-CoV-2, influenza)."
batch,Technical or experimental batch ID within one study
title,Sample title from GEO metadata.
timepoint,Exact time or day post-vaccination/infection.
timepoint_group,Categorical grouping of timepoints
infection_group,"Infection status grouping (e.g., infected vs. uninfected); represents the outcome in inoculation studies."
symptom_group,"Symptom severity group (e.g., symptomatic vs. asymptomatic); represents the outcome in inoculation studies."
symptom_group_original,Original symptom classification from source study.
Total_DSS,Disease Severity Score (quantitative summary of symptoms).
MFC,Maximum fold change (MFC)
responder,"Indicator of vaccine response (e.g., responder, moderate responder, or non-responder), defined based on Maximum Fold Change (MFC)."
responder_original,Original response classification before harmonization.
study_group,"Group assignment within a study (e.g., vaccine arm, control)."
Enrollment_year,Year when participant enrolled in the study.
vaccine,"Vaccine type (e.g., mRNA-1273, BNT162b2)."
vaccine_dose,"Vaccine dose number (e.g., 1st, 2nd, 3rd)."
sex,Biological sex (Male/Female).
age,Participant age in years.
age_group,"Age category (e.g., 18–30, 31–50, >50)."
immport_expsamp_acc,ImmPort experiment sample accession.
Expsample.Accession,Alternate experimental sample accession in ImmPort
ethnicity,"Participant ethnicity (e.g., Hispanic, non-Hispanic)."
race,"Race as recorded in metadata (e.g., White, Asian, Black)."
race_ethnicity,Combined race and ethnicity classification.
sham,Indicator for sham or placebo treatment.
BMI,Body Mass Index (kg/m²).
PreviousCOVID19,Prior SARS-CoV-2 infection (Yes/No).
symptom_group_previous_covid,Symptom group classification for previously infected individuals.
UnderlyingDisease,Presence of underlying or chronic medical conditions.
turbo_reatment,Indicator of whether the RNA sample was treated with TurboDNase (Thermo Fisher Scientific) to remove contaminating genomic DNA during RNA extraction. Marked as “Turbo Treated” if DNase treatment was applied.
Medications,Medications taken by participant during study.
side_effect,Reported vaccine side effects.
Duration_of_symptoms,Duration (in days) of reported symptoms.
days.since.covid.19.diagnosis,Days since COVID-19 diagnosis at time of sampling.
Vaccinated.in.prior.3.seasons,Whether vaccinated in the prior three influenza seasons (Yes/No).
influenza.vaccination.count..previous.10.years.,Number of influenza vaccinations received in the previous 10 years.
Height_cm,Height in centimeters.
Weight_kg,Weight in kilograms.
Current.smoker,Current smoking status (Yes/No).
Prior.smoker,Former smoking status (Yes/No).
Sleep.apnea,Presence of sleep apnea (Yes/No).
diabetes,Presence of diabetes (Yes/No).
seroconversion,Binary or quantitative measure of antibody seroconversion.
viral_shedding,Presence or level of viral shedding post-infection or vaccination.